result 1048 件
| FullText URL | jfl_071_contents_eng.pdf |
|---|---|
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56881 |
|---|---|
| FullText URL | jfl_071_(001)_(019).pdf |
| Author | Imazu, Katsunori| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | (1) |
| End Page | (19) |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006648631 |
| FullText URL | jfl_071_081_099.pdf |
|---|---|
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 81 |
| End Page | 99 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56879 |
|---|---|
| FullText URL | jfl_071_063_080.pdf |
| Author | SCHILLING, Anette| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 63 |
| End Page | 80 |
| ISSN | 0285-4864 |
| language | German |
| File Version | publisher |
| NAID | 120006648630 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56878 |
|---|---|
| FullText URL | jfl_071_047_062.pdf |
| Author | Nakatani, Hitomi| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 47 |
| End Page | 62 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006648629 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56877 |
|---|---|
| FullText URL | jfl_071_035_045.pdf |
| Author | Ando, Mikayo| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 35 |
| End Page | 45 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006648628 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56876 |
|---|---|
| FullText URL | jfl_071_017_034.pdf |
| Author | Nakao, Tomoyo| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 17 |
| End Page | 34 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006648627 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56875 |
|---|---|
| FullText URL | jfl_071_001_015.pdf |
| Author | Fujii, Wasa| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006648626 |
| FullText URL | jfl_071_contents.pdf |
|---|---|
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2019-06-28 |
| Volume | volume71 |
| ISSN | 0285-4864 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/56873 |
|---|---|
| FullText URL | 73_3_279.pdf |
| Author | Makimoto, Go| Nishimori, Hisakazu| Kondo, Reiko| Yanai, Hiroyuki| Sugimoto, Morito| Oda, Naohiro| Kubo, Toshio| Hotta, Katsuyuki| Tabata, Masahiro| Kiura, Katsuyuki| Maeda, Yoshinobu| |
| Abstract | Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma. |
| Keywords | urothelial carcinoma uroplakin III s-pancreas-1 antigen carbohydrate antigen 19-9 chemotherapy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 284 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235978 |
| JaLCDOI | 10.18926/AMO/56872 |
|---|---|
| FullText URL | 73_3_273.pdf |
| Author | Hayata, Kei| Masuyama, Hisashi| Eto, Eriko| Mitsui, Takashi| Tamada, Shoko| Eguchi, Takeshi| Maki, Jota| Tani, Kazumasa| Ohira, Akiko| Washio, Yosuke| Yoshimoto, Junko| Hasegawa, Kosei| |
| Abstract | Nager syndrome is a rare disease involving severe micrognathia and upper limb shortening. In this report, we describe a case in which micrognathia of the fetus was suspected based on the observation of upper limb shortening during detailed B mode and 3D/4D ultrasonographic observation, and combined fetal MRI and 3D-CT led to a prenatal diagnosis of Nager syndrome. Upon birth, because severe micrognathia caused airway obstruction and made it difficult to spread the larynx for intubation, effective ventilation could not be carried out and a tracheostomy was necessary. Since a differential diagnosis of Nager syndrome can be made based on the fact that micrognathia typically co-occurs with upper limb shortening, it is possible to diagnose the disease before birth and prepare for life-saving measures accordingly. |
| Keywords | Nager syndrome acrofacial dysostosis micrognathia jaw index SF3B4 |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235977 |
| JaLCDOI | 10.18926/AMO/56871 |
|---|---|
| FullText URL | 73_3_269.pdf |
| Author | Tsuboi, Ichiro| Araki, Motoo| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Hiraki, Takao| Arichi, Naoko| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Sako, Tomoko| Takamoto, Atsushi| Wada, Koichiro| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Yanai, Hiroyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Shiina, Hiroaki| Kanazawa, Susumu| Nasu, Yasutomo| |
| Abstract | Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new treatment option for treating small-sized renal cell cancer (RCCs). We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up. |
| Keywords | cryoablation partial nephrectomy renal cell carcinoma renal allograft renal transplantation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 269 |
| End Page | 272 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235976 |
| JaLCDOI | 10.18926/AMO/56870 |
|---|---|
| FullText URL | 73_3_263.pdf |
| Author | Shimoyama, Yuichiro| Umegaki, Osamu| Ooi, Yukimasa| Shigemoto, Sho| Agui, Tomoyuki| Kadono, Noriko| Minami, Toshiaki| |
| Abstract | A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and was diagnosed with adrenal insufficiency accompanied by septic shock. He died of multiple organ failure 29 h post-admission to our ICU. |
| Keywords | fulminant type 1 diabetes mellitus human immunodeficiency virus cytomegalovirus hypoglycemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 267 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235975 |
| JaLCDOI | 10.18926/AMO/56869 |
|---|---|
| FullText URL | 73_3_255.pdf |
| Author | Seki, Daisuke| Takeshita, Nobuo| Seiryu, Masahiro| Deguchi, Toru| Takano-Yamamoto, Teruko| |
| Abstract | Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population. |
| Keywords | Axenfeld-Rieger syndrome external apical root resorption miniscrew implant anterior open bite |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235974 |
| JaLCDOI | 10.18926/AMO/56868 |
|---|---|
| FullText URL | 73_3_247.pdf |
| Author | Yoshio, Kotaro| Wakita, Akihisa| Mitsuhashi, Toshiharu| Kitayama, Takahiro| Hisazumi, Kento| Inoue, Daisaku| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu| |
| Abstract | We investigated the feasibility of simultaneous integrated boost (SIB) volumetric modulated arc therapy (VMAT) using elective nodal irradiation (ENI) for middle or lower esophageal cancer and compared it with three-dimensional conformal radiotherapy (3D-CRT). The study included 15 patients. The prescribed doses included a standard dose (50.4 Gy) and a high dose (60 Gy) for the planning target volume (PTV) of the involved lesions. The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was < 30%, and the mean lung dose (MLD) was < 20 Gy. The volumes of the lung receiving 5 Gy (V5Gy) and the heart receiving 30-50 Gy (V30-50Gy) were kept as low as reasonably achievable. As a result, SIB-VMAT showed superior dose conformity for the PTV (p<0.001). Although the lung V5Gy was significantly increased (p<0.001), the V20Gy and MLD showed no significant increase. The heart V30-50Gy showed a > 20% reduction in the mean against 3D-CRTs. Our results demonstrate the feasibility of SIB-VMAT for the treatment of middle or lower esophageal cancer with ENI. Although attention should be paid to the low-dose area of the lungs, SIB-VMAT would be a promising treatment option with improved outcomes for esophageal cancer. |
| Keywords | esophageal cancer middle and lower thoracic volumetric modulated arc therapy, 3D-CRT elective nodal irradiation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235973 |
| reference | Infusino E: Clinical utility of RapidArcTM radiotherapy technology. Cancer Manage Res (2015) 7: 345-356.| Cozzi L, Dinshaw KA, Shrivastava SK, Mahantshetty U, Engineer R, Deshpande DD, Jamema SV, Vanetti E, Clivio A, Nicolini G and Fogliata A: A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother Oncol (2008) 89: 180-191.| Vanetti E, Clivio A, Nicolini G, Fogliata A, Ghosh-Laskar S, Agarwal JP, Upreti RR, Budrukkar A, Murthy V, Deshpande DD, Shrivastava SK, Dinshaw KA and Cozzi L: Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT. Radiother Oncol (2009) 92: 111-117.| Palma D, Vollans E, James K, Nakano S, Moiseenko V, Shaffer R, McKenzie M, Morris J and Otto K: Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys (2008) 72: 996-1001.| Clivio A, Fogliata A, Franzetti-Pellanda A, Nicolini G, Vanetti E, Wyttenbach R and Cozzi L: Volumetric-modulated arc radiotherapy for carcinomas of the anal canal: A treatment planning comparison with fixed field IMRT. Radiother Oncol (2009) 92: 118-124.| Wagner D, Christiansen H, Wolff H and Vorwerk H: Radiotherapy of malignant gliomas: comparison of volumetric single arc technique (RapidArc), dynamic intensity-modulated technique and 3D conformal technique. Radiother Oncol (2009) 93: 593-596.| Van Benthuysen L, Hales L and Podgorsak MB: Volumetric modulated arc therapy vs. IMRT for the treatment of distal esophageal cancer. Med Dosim (2011) 36: 404-409.| Yin L, Wu H, Gong J, Geng JH, Jiang F, Shi AH, Yu R, Li YH, Han SK, Xu B and Zhu GY: Volumetric-modulated arc therapy vs. c-IMRT in esophageal cancer: a treatment planning comparison. World J Gastroenterol (2012) 18: 5266-5275.| Vivekanandan N, Sriram P, Kumar SA, Bhuvaneswari N and Saranya K: Volumetric modulated arc radiotherapy for esophageal cancer. Med Dosim (2012) 37: 108-113.| Nicolini G, Ghosh-Laskar S, Shrivastava SK, Banerjee S, Chaudhary S, Agarwal JP, Munshi A, Clivio A, Fogliata A, Mancosu P, Vanetti E and Cozzi L: Volumetric modulation arc radiotherapy with flattening filter-free beams compared with static gantry IMRT and 3D conformal radiotherapy for advanced esophageal cancer: a feasibility study. Int J Radiat Oncol Biol Phys (2012) 84: 553-560.| Martin S, Chen JZ, Rashid Dar A and Yartsev S: Dosimetric comparison of helical tomotherapy, RapidArc, and a novel IMRT & Arc technique for esophageal carcinoma. 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J Clin Oncol (1999) 17: 2915-2921.| Kato K, Muro K, Minashi K, Ohtsu A, Ishikura S, Boku N, Takiuchi H, Komatsu Y, Miyata Y and Fukuda H: Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for Stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906). Int J Radiat Oncol Biol Phys (2011) 81: 684-690.| Kato K, Nakajima TE, Ito Y, Katada C, Ishiyama H, Tokunaga SY, Tanaka M, Hironaka S, Hashimoto T, Ura T, Kodaira T and Yoshimura K: Phase II study of concurrent chemoradiotherapy at the dose of 50.4 Gy with elective nodal irradiation for Stage II-III esophageal carcinoma. Jpn J Clin Oncol (2013) 43: 608-615.| Onozawa M, Nihei K, Ishikura S, Minashi K, Yano T, Muto M, Ohtsu A and Ogino T: Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus. Radiother Oncol (2009) 92: 266-269.| Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, Asbell SO, Graham MV and Leichman LL: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA (1999) 281: 1623-1627.| Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA and Kelsen DP: INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol (2002) 20: 1167-1174.| Welsh J, Settle SH, Amini A, Xiao L, Suzuki A, Hayashi Y, Hofstetter W, Komaki R, Liao Z and Ajani JA: Failure patterns in patients with esophageal cancer treated with definitive chemoradiation. Cancer (2012) 118:2632-2640.| Yu WW, Zhu ZF, Fu XL, Zhao KL, Mao JF, Wu KL, Yang HJ, Fan M, Zhao S and Welsh J: Simultaneous integrated boost intensity-modulated radiotherapy in esophageal carcinoma: early results of a phase II study. Strahlenther Onkol (2014) 190: 979-986.| Roeder F, Nicolay NH, Nguyen T, Saleh-Ebrahimi L, Askoxylakis V, Bostel T, Zwicker F, Debus J, Timke C and Huber PE: Intensity modulated radiotherapy (IMRT) with concurrent chemotherapy as definitive treatment of locally advanced esophageal cancer. Radiat Oncol (2014) 9: 191.| Chang CL, Tsai HC, Lin WC, Chang JH, Hsu HL, Chow JM, Yuan KS, Wu ATH and Wu SY: Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma. Radiother Oncol (2017) 125: 73-79.| Alongi F, Fogliata A, Navarria P, Tozzi A, Mancosu P, Lobefalo F, Reggiori G, Clivio A, Cozzi L and Scorsetti M: Moderate hypofractionation and simultaneous integrated boost with volumetric modulated arc therapy (RapidArc) for prostate cancer. Report of feasibility and acute toxicity. Strahlenther Onkol (2012) 188: 990-996.| Peponi E, Glanzmann C, Kunz G, Renner C, Tomuschat K and Studer G: Simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in nasopharyngeal cancer. Strahlenther Onkol (2010) 186: 135-142.| Vandecasteele K, De Neve W, De Gersem W, Delrue L, Paelinck L,Makar A, Fonteyne V, De Wagter C, Villeirs G and De Meerleer G: Intensity-modulated arc therapy with simultaneous integrated boost in the treatment of primary irresectable cervical cancer. Treatment planning, quality control, and clinical implementation. Strahlenther Onkol (2009) 185: 799-807.| Ogino I, Watanabe S, Sakamaki K, Ogino Y, Kunisaki C and Kimura K: Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer. Strahlenther Onkol (2017) 193: 552-560.| Wei X, Liu HH, Tucker SL, Wang S, Mohan R, Cox JD, Komaki R and Liao Z: Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys (2008) 70: 707-714.| Grosshans D, Boehling NS, Palmer M, Spicer C, Erice R, Cox JD, Komaki R and Chang JY: Improving cardiac dosimetry: Alternative beam arrangements for intensity modulated radiation therapy planning in patients with carcinoma of the distal esophagus. Pract Radiat Oncol (2012) 2: 41-45.| Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, El Naqa I, Hubbs JL, Lebesque JV, Timmerman RD, Martel MK and Jackson A: Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys (2010) 76(3 Suppl): S70-S76.| Paddick I: A simple scoring ratio to index the conformity of radiosurgical treatment plans. Technical note. J. Neurosurg (2000) 93 Suppl 3: 219-222. | Feuvret L, Noël G, Mazeron JJ and Bey P: Conformity index: a review. Int J Radiat Oncol Biol Phys (2006) 64: 333-342.| Fukada J, Shigematsu N, Takeuchi H, Ohashi T, Saikawa Y, Takaishi H, Hanada T, Shiraishi Y, Kitagawa Y and Fukuda K: Symptomatic pericardial effusion after chemoradiation therapy in esophageal cancer patients. Int J Radiat Oncol Biol Phys (2013) 87: 487-493.| Gayed IW, Liu HH, Yusuf SW, Komaki R, Wei X, Wang X, Chang JY, Swafford J, Broemeling L and Liao Z: The prevalence of myocardial ischemia after concurrent chemoradiation therapy as detected by gated myocardial perfusion imaging in patients with esophageal cancer. J Nucl Med (2006) 47: 1756-1762.| Speirs CK, DeWees TA, Rehman S, Molotievschi A, Velez MA, Mullen D, Fergus S, Trovo M, Bradley JD and Robinson CG: Heart Dose Is an Independent Dosimetric Predictor of Overall Survival in Locally Advanced Non-Small Cell Lung Cancer. J Thorac Oncol (2017) 12: 293-301.| Nutting CM, Bedford JL, Cosgrove VP, Tait DM, Dearnaley DP and Webb S: A comparison of conformal and intensity-modulated techniques for oesophageal radiotherapy. Radiother Oncol (2001) 61: 157-163.| Yom SS, Liao Z, Liu HH, Tucker SL, Hu CS, Wei X, Wang X, Wang S, Mohan R, Cox JD and Komaki R: Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys (2007) 68: 94-102.| Shaikh T, Churilla TM, Monpara P, Scott WJ, Cohen SJ and Meyer JE: Risk of radiation pneumonitis in patients receiving taxane-based trimodality therapy for locally advanced esophageal cancer. Pract Radiat Oncol (2016) 6: 388-394.| Shirakawa Y, Noma K, Maeda N, Tanabe S, Kuroda S, Kagawa S, Katsui K, Katayama N, Kanazawa S and Fujiwara T: Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer. Acta Med Okayama (2017) 71: 127-133.| |
| JaLCDOI | 10.18926/AMO/56867 |
|---|---|
| FullText URL | 73_3_241.pdf |
| Author | Utsumi, Masashi| Aoki, Hideki| Nishimura, Seitaro| Une, Yuta| Kashima, Hajime| Kimura, Yuji| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| Abstract | Gallbladder carcinoma (GBC) is a common malignancy with a poor prognosis. With the average life expectancy increasing globally, the incidence of GBC is predicted to increase as well. We investigated the safety and feasibility of surgical treatment for elderly patients with GBC. We retrospectively compared clinical pathological data and treatment outcomes in 45 consecutive GBC patients (23 patients ≥ 75 years [elderly group] and 22 patients < 75 years [younger group]) who underwent curative resection at the Iwakuni Center from January 2008 to December 2017. The proportion of preoperative comorbidities and anticoagulant use was significantly higher in the elderly group. The American Society of Anesthesiologists score was higher in the elderly versus the younger group, and the elderly group had significantly shorter operation times. Reduced activities of daily living was more common in the elderly versus younger group. The percentage of radical resection and overall 3-year survival (66.6% younger vs. 64.4% elderly) were similar between the groups. Controlling Nutritional Status (CONUT) score ≥ 3 and R0 resection were identified as prognostic factors for overall survival rate among all patients. After careful patient selection, |
| Keywords | elderly patient gallbladder carcinoma prognostic factor surgical treatment |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 241 |
| End Page | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235972 |
| JaLCDOI | 10.18926/AMO/56866 |
|---|---|
| FullText URL | 73_3_235.pdf |
| Author | Horita, Masahiro| Nishida, Keiichiro| Hashizume, Kenzo| Sugimoto, Yoshihisa| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Ozaki, Toshifumi| |
| Abstract | We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) were classified as the non-progressive group, and the other 9 patients (18.4%) comprised the progressive group. The progressive group’s final CRP values, baseline or final MMP-3 levels, DAS28-CRP, and rate of pre-existing lesions at baseline were all significantly higher than those of the non-progressive group (p=0.017, p=0.043, p=0.002, p=0.008, p<0.001, and p=0.008 respectively). A multivariate logistic regression analysis demonstrated that DAS28-CRP at baseline was a risk factor for radiographic progression (p=0.018, odds ratio: 2.54, 95% confidence interval: 1.17-5.51). Our findings indicate that higher disease activity might influence the progression of UCLs in patients with RA. |
| Keywords | rheumatoid arthritis upper cervical spine lesion risk factor radiological progression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235971 |
| JaLCDOI | 10.18926/AMO/56865 |
|---|---|
| FullText URL | 73_3_229.pdf |
| Author | Hamasaki, Ichiro| Shibata, Kiyo| Shimizu, Takehiro| Kono, Reika| Morizane, Yuki| Shiraga, Fumio| |
| Abstract | During strabismus surgery using illumination from a light source, patients complain of photophobia. The NGENUITYⓇ (Alcon) system is equipped with a high-dynamic-range (HDR) camera. A 4K display viewed by wearing circularly polarized glasses provides clear three-dimensional images of the operative field. A light source is usually required for surgeries of the anterior segment (including strabismic surgery), but the digital processing function of the NGENUITYⓇ system allows image display in relatively dark regions even without a light source. We devised a novel ‘lights-out’ surgery that does not use a microscope’s light source, and we examined the usefulness of this technique in 2 cases of strabismic surgery. We performed strabismus surgery using the NGENUITYⓇ system in two patients between January and June 2018. The HDR function was used, and the aperture was opened to the maximum while the gain was adjusted. Surgery was conducted without using the microscope’s light source. We report the 2 cases’ results and evaluate the novel method. The surgeries were performed without problem even though the microscope’s light source was not used. The patients’ photophobia was alleviated. Lights-out surgery is a potentially useful modality for strabismus surgery. |
| Keywords | head-up surgery 3D vision system high dynamic range video enhancement strabismus surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 229 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235970 |
| JaLCDOI | 10.18926/AMO/56864 |
|---|---|
| FullText URL | 73_3_223.pdf |
| Author | Sugiu, Kazuhisa| Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Okazaki, Yoshiki| Okazaki, Yuki| Hiranaka, Takaaki| Ozaki, Toshifumi| |
| Abstract | Anterior cruciate ligament (ACL) reconstruction (ACLR) after ACL rupture improves the instability of the knee joint and decreases mechanical stress to the meniscus and articular cartilage. However, there are reports that post-traumatic osteoarthritis (PTOA) is observed over time following ACLR. In this study, we assessed changes in cartilage lesions by arthroscopic findings following anatomical double-bundle ACLR and at post-operative second-look arthroscopy about 14 months later. We retrospectively evaluated 37 knees in cases with patients <40 years of age who had undergone an anatomical double-bundle ACL reconstruction <1 year after ACL rupture injury from March 2012 to December 2016. Clinical results and arthroscopic cartilage/meniscal lesion were evaluated and compared between a cartilage lesion-detected group and intact-cartilage group. Surgery improved anteroposterior laxity and other clinical measures; however, cartilage lesions were detected at 11 sites during ACLR and at 54 sites at second-look arthroscopy. The periods from injury to second-look arthroscopy and from ACLR to second-look arthroscopy were significantly longer in the cartilage-lesion group (n=23) than in the intact-cartilage group (n=14). Conversely, 96% of meniscal damage observed during ACLR was cured at the time of second-look arthroscopy. Knee articular cartilage lesions after ACL rupture cannot be completely suppressed, even using the anatomical ACL reconstruction technique. This study suggested that articular cartilage lesions can progress to a level that can be confirmed arthroscopically at approximately 17 months after ACL injury. Therefore, in ACLR patients, the possibility of developing knee articular cartilage lesions and PTOA should be considered. |
| Keywords | anterior cruciate ligament reconstruction post-traumatic osteoarthritis meniscal lesion cartilage lesions second-look arthroscopy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 223 |
| End Page | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235969 |
| JaLCDOI | 10.18926/AMO/56863 |
|---|---|
| FullText URL | 73_3_213.pdf |
| Author | Nishina, Saori| Matsuura, Koji| Naruse, Keiji| |
| Abstract | We investigated the relationship between human sperm rheotaxis and motile sperm trajectories by using poly-(dimethylsiloxane) (PDMS)-based cylindrical microfluidic channels with inner diameters of 100 μm, 50 μm, and 70 μm, which corresponded to the inner diameter of the human isthmus, the length of a sperm and a diameter intermediate between the two, respectively. We counted the number of rheotaxic sperm and sperm with spiral motion. We also analyzed motile sperm trajectories. As the cylindrical channel diameter was decreased, the percentage of sperm cells exhibiting rheotaxis, the percentage of sperm cells exhibiting spiral motion, the frequency-to-diameter ratio of the sperm cells’ spiral trajectories, and the surface area of the microfluidic channel increased, while the flagellar motion at the channel wall decreased. The percentage of sperm exhibiting a spiral trajectory and the frequency-to-diameter ratio of the sperm cells’ spiral trajectories were thus affected by the channel diameter. Our findings suggest that the oviduct structure affects the swimming properties of sperm cells, guiding them from the uterus to the ampulla for egg fertilization. These results could contribute to the development of motile sperm-sorting microfluidic devices for assisted reproductive technologies. |
| Keywords | sperm motility trajectory microfluidic channel rheotaxis oviduct structure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 221 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235968 |
