result 1465 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Soejima, Yoshiaki| Otsuka, Yuki| Kawaguchi, Marina| Oguni, Kohei| Yamamoto, Koichiro| Nakano, Yasuhiro| Yasuda, Miho| Tokumasu, Kazuki| Ueda, Keigo| Hasegawa, Kosei| Iwata, Nahoko| Otsuka, Fumio| |
| Keywords | fibroblast growth factor receptor 1 (FGFR1) gynecomastia Kallmann syndrome (KS) osteoporosis and steroidogenesis |
| Published Date | 2025-03-18 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 2713 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40141355 |
| DOI | 10.3390/ijms26062713 |
| Web of Science KeyUT | 001452479200001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26062713 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujii, Yuki| Matsumoto, Kazuyuki| Ochi, Kiyoaki| Himei, Hitomi| Sakakihara, Ichiro| Ueta, Eijiro| Toyokawa, Tatsuya| Harada, Ryo| Ogawa, Taiji| Tomoda, Takeshi| Kato, Hironari| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Otsuka, Motoyuki| |
| Keywords | clipping closure delayed bleeding endoscopic papillectomy |
| Published Date | 2025 |
| Publication Title | Therapeutic Advances in Gastroenterology |
| Volume | volume18 |
| Publisher | SAGE Publications |
| ISSN | 1756-2848 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), 2025. |
| File Version | publisher |
| PubMed ID | 40104325 |
| DOI | 10.1177/17562848251326450 |
| Web of Science KeyUT | 001447404800001 |
| Related Url | isVersionOf https://doi.org/10.1177/17562848251326450 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yumoto, Tetsuya| Obara, Takafumi| Hongo, Takashi| Iida, Atsuyoshi| Tsukahara, Kohei| Katsura, Morihiro| Kondo, Yutaka| Yasuda, Hideto| Kushimoto, Shigeki| Yorifuji, Takashi| Naito, Hiromichi| Nakao, Atsunori| SHIPPs Study Group| |
| Keywords | Abdominal injuries Blood transfusions Hemoglobin Hemostasis Shock index |
| Published Date | 2025-03-12 |
| Publication Title | Scientific Reports |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 8502 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40074821 |
| DOI | 10.1038/s41598-025-92673-7 |
| Web of Science KeyUT | 001443941100009 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-025-92673-7 |
| JaLCDOI | 10.18926/AMO/68363 |
|---|---|
| FullText URL | 79_1_059.pdf |
| Author | Minakawa, Shun| Hirano, Masayuki| Takahashi, Kazuya| Imamura, Yuta| Watanabe, Takashi| |
| Abstract | Intraorbital arteriovenous fistulas (IOAVFs) are rare vascular abnormalities. We describe a case of an IOAVF featuring a direct shunt between the accessory meningeal artery and the superior ophthalmic artery. A 55-year-old woman presented with a 1-month history of visual impairment in her right eye, and magnetic resonance imaging (MRI) revealed optic neuritis-like findings. Steroid pulse therapy temporarily resolved visual impairment. However, 1 month later, she experienced decreased visual acuity, ocular conjunctival hyperemia, edema, and a pulsatile murmur. Contrast-enhanced MRI and digital subtraction angiography revealed compression optic neuropathy due to an IOAVF. Following successful treatment with transarterial embolization, her symptoms disappeared. |
| Keywords | intraorbital arteriovenous fistula compressive optic neuropathy accessory meningeal artery superior ophthalmic vein |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 59 |
| End Page | 64 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012161 |
| Web of Science KeyUT | 001440463800008 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ooba, Hikaru| Maki, Jota| Masuyama, Hisashi| |
| Keywords | Perinatal mental disorders Voice analysis Machine learning Screening Pregnant women |
| Published Date | 2025-02-08 |
| Publication Title | Discover Mental Health |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 12 |
| ISSN | 2731-4383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 39920468 |
| DOI | 10.1007/s44192-025-00138-0 |
| Web of Science KeyUT | 001415532800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s44192-025-00138-0 |
| JaLCDOI | 10.18926/AMO/68354 |
|---|---|
| FullText URL | 79_1_009.pdf |
| Author | Ikeya, Nanami| Okita, Atsushi| Hashida, Shinsuke| Yamamoto, Sumiharu| Ikeda, Hirokuni| Tsukuda, Kazunori| Toyooka, Shinichi| |
| Abstract | Muscle loss negatively affects gastrectomy prognosis. However, muscle loss is recognized as a systemic change, and individual muscle function is often overlooked. We investigated changes in the muscle volume of individual muscles after gastrectomy to identify clues for prognostic factors and optimal rehabilitation programs. Patients who underwent R0 gastrectomy for Stage I gastric cancer at our hospital from 2015 to 2021 were retrospectively selected to minimize the effects of malignancy and chemotherapy. Trunk muscle volume was measured by computed tomography to analyze body composition changes. Statistical analysis was performed to identify risk factors related to body composition changes. We compared the preoperative and 6-month postoperative conditions of 59 patients after gastrectomy. There was no difference in the psoas major muscle, a conventional surrogate marker of sarcopenia. There were significant decreases in the erector spinae (p=0.01) and lateral abdominal (p=0.01) muscles, and a significant increase in the rectus abdominis muscle (p=0.02). No significant correlation was found between these muscle changes and nutritional status. Body composition imbalance may serve as a new indicator of the general condition of patients after gastrectomy. Rehabilitation to correct this imbalance may improve prognosis after gastrectomy. |
| Keywords | sarcopenia skeletal muscle gastric cancer gastrectomy erector spinae muscle |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012155 |
| Web of Science KeyUT | 001440463800002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Nakahara, Ryuichi| Otsuka, Yujiro| Nakamura, Yusuke| Ikuta, Kunihiro| Osaki, Shuhei| Hironari, Tamiya| Miwa, Shinji| Ohshika, Shusa| Nishimura, Shunji| Kahara, Naoaki| Yoshida, Aki| Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | osteosarcoma medical image annotation anatomical annotation method rare cancer |
| Published Date | 2024-12-25 |
| Publication Title | Cancers |
| Volume | volume17 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 29 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39796660 |
| DOI | 10.3390/cancers17010029 |
| Web of Science KeyUT | 001393409100001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers17010029 |
| Author | Zou, Yajuan| Ohkura, Kentaro| Ortiz‐Anaya, Israel| Kimura, Ryota| Bianco, Alberto| Nishina, Yuta| |
|---|---|
| Keywords | Carbon nanomaterials Epoxide ring-opening Catalysis Polyglycerol functionalization |
| Note | This is the peer reviewed version of the following article: [Y. Zou, K. Ohkura, I. Ortiz-Anaya, R. Kimura, A. Bianco, Y. Nishina, Chem. Eur. J. 2025, e202404400. https://doi.org/10.1002/chem.202404400], which has been published in final form at [https://doi.org/10.1002/chem.202404400]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jan. 2026.| |
| Published Date | 2025-01-07 |
| Publication Title | Chemistry – A European Journal |
| Publisher | Wiley |
| Start Page | e202404400 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Wiley-VCH GmbH |
| File Version | publisher |
| PubMed ID | 39714895 |
| DOI | 10.1002/chem.202404400 |
| Web of Science KeyUT | 001390977300001 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.202404400 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanaka, Hideki| Matsumoto, Masakazu| Yagasaki, Takuma| |
| Published Date | 2023-11-21 |
| Publication Title | The Journal of Chemical Physics |
| Volume | volume159 |
| Issue | issue19 |
| Publisher | AIP Publishing |
| Start Page | 194504 |
| ISSN | 0021-9606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37987520 |
| DOI | 10.1063/5.0179655 |
| Web of Science KeyUT | 001107770700002 |
| Related Url | isVersionOf https://doi.org/10.1063/5.0179655 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kanaya, Nobuhiko| Kuroda, Shinji| Kondo, Yoshitaka| Takehara, Yuko| Kakiuchi, Yoshihiko| Minagi, Hitoshi| Sakamoto, Masaki| Kagawa, Shunsuke| Kataoka, Hitomi| Fujiwara, Toshiyoshi| |
| Keywords | Optimization of workflow processes Sustainable paternity participation “Daddy surgeon” |
| Note | The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00595-024-02959-y| |
| Published Date | 2024-12-07 |
| Publication Title | Surgery Today |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39644389 |
| DOI | 10.1007/s00595-024-02959-y |
| Web of Science KeyUT | 001371519800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-024-02959-y |
| JaLCDOI | 10.18926/AMO/67870 |
|---|---|
| FullText URL | 78_6_449.pdf |
| Author | Kato, Gentaro| Ogawa, Tatsuya| Hayashida, Tomohiro| Shimizu, Shuji| Yamamoto, Shu| Shichijo, Takeshi| |
| Abstract | A 73-year-old man who had undergone esophagectomy and retrosternal gastric tube reconstruction for esophageal cancer 8 years prior was transferred to our hospital for the treatment of an acute myocardial infarction. Emergent percutaneous coronary intervention for the left anterior descending artery (#7) was successfully performed. However, echocardiography revealed a ventricular septal rupture (25×27 mm). Seventeen days after admission, the rupture was successfully treated with a double-patch closure via a left anterolateral thoracotomy to avoid a surgical injury to his retrosternal gastric tube. Determining the best surgical approach to the heart is important for safe cardiac surgery in patients after esophageal reconstruction. |
| Keywords | acute myocardial infarction ventricular septal rupture retrosternal gastric tube reconstruction esophageal cancer left anterolateral thoracotomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 452 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719317 |
| Web of Science KeyUT | 001397799300003 |
| JaLCDOI | 10.18926/AMO/67869 |
|---|---|
| FullText URL | 78_6_439.pdf |
| Author | Yamashita, Mampei| Tanaka, Takayuki| Sumida, Yorihisa| Yamazaki, Shoto| Hara, Yuki| Fukuda, Akiko| Hisanaga, Makoto| Wakata, Koki| Araki, Masato| Eguchi, Susumu| |
| Abstract | Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken. |
| Keywords | gangrenous cholecystitis acute cholecystitis laparoscopic cholecystectomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 439 |
| End Page | 447 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719316 |
| Web of Science KeyUT | 001397799300002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mino, Takuya| Kurosaki, Yoko| Tokumoto, Kana| Izumi, Koji| Mitsumune, Hiroshi| Maekawa, Kenji| Ueda, Akihiro| Nakano, Tomohito| Sejima, Junichi| Kimura-Ono, Aya| Kuboki, Takuo| |
| Keywords | Computer-aided design Dental implants Superstructure Provisional restoration Digital workflow |
| Published Date | 2023 |
| Publication Title | Journal of Prosthodontic Research |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Japan Prosthodontic Society |
| Start Page | 139 |
| End Page | 146 |
| ISSN | 1883-1958 |
| NCID | AA12395171 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Japan Prosthodontic Society. |
| File Version | publisher |
| PubMed ID | 37211412 |
| DOI | 10.2186/jpr.jpr_d_22_00244 |
| Web of Science KeyUT | 000995872100001 |
| Related Url | isVersionOf https://doi.org/10.2186/jpr.jpr_d_22_00244 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furumatsu, Takayuki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Posterior root Partial tear Meniscal extrusion Operative indication |
| Note | The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00182-6| |
| Published Date | 2023-03-14 |
| Publication Title | Knee Surgery & Related Research |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 8 |
| ISSN | 2234-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 36918982 |
| DOI | 10.1186/s43019-023-00182-6 |
| Web of Science KeyUT | 000949319200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s43019-023-00182-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Hioki, Masayoshi| Yoshida, Ryuichi| Endo, Yoshikatsu| Yasui, Kazuya| Nobuoka, Daisuke| Mitsuhashi, Toshiharu| Fujiwara, Toshiyoshi| |
| Keywords | Education High-volume hospital Learning curve Pancreaticoduodenectomy |
| Note | The version of record of this article, first published in BMC Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12893-024-02677-9| |
| Published Date | 2024-11-20 |
| Publication Title | BMC Surgery |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 366 |
| ISSN | 1471-2482 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39563307 |
| DOI | 10.1186/s12893-024-02677-9 |
| Web of Science KeyUT | 001360181700004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12893-024-02677-9 |
| Author | Tanaka, Shunji| ElWakil, Mohamed| Eltawil, Amr| |
|---|---|
| Keywords | Logistics Parallel stack loading problem Relocation Integer programming Branch-and-bound algorithm |
| Note | © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jun. 2027.| |
| Published Date | 2024-9 |
| Publication Title | Computers & Operations Research |
| Volume | volume169 |
| Publisher | Elsevier BV |
| Start Page | 106712 |
| ISSN | 0305-0548 |
| NCID | AA00613617 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Elsevier Ltd. |
| File Version | author |
| DOI | 10.1016/j.cor.2024.106712 |
| Web of Science KeyUT | 001346826000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.cor.2024.106712 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Xiao, Yanqi| Funabiki, Nobuo| Anggraini, Irin Tri| Shih, Cheng-Liang| Fan, Chih-Peng| |
| Keywords | exergame tenosynovitis hand gesture Python Mediapipe |
| Published Date | 2024-10-10 |
| Publication Title | Information |
| Volume | volume15 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 622 |
| ISSN | 2078-2489 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| DOI | 10.3390/info15100622 |
| Web of Science KeyUT | 001343224500001 |
| Related Url | isVersionOf https://doi.org/10.3390/info15100622 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mwendwa Wambua, Daniel| Somura, Hiroaki| Moroizumi, Toshitsugu| |
| Keywords | climate change adaptation scenarios downscaling disaggregation temporal |
| Published Date | 2024 |
| Publication Title | Hydrological Research Letters |
| Volume | volume18 |
| Issue | issue4 |
| Publisher | Japan Society of Hydrology and Water Resources |
| Start Page | 87 |
| End Page | 94 |
| ISSN | 1882-3416 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| DOI | 10.3178/hrl.18.87 |
| Web of Science KeyUT | 001333204000001 |
| Related Url | isVersionOf https://doi.org/10.3178/hrl.18.87 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamada, Motohiko| Takagi, Kosei| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Nishiyama, Takeyoshi| Nagai, Yasuo| Kanehira, Noriyuki| Fujiwara, Toshiyoshi| |
| Keywords | laparoscopic liver resection surgical difficulty liver transection area |
| Published Date | 2024-09-24 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume13 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 5686 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39407746 |
| DOI | 10.3390/jcm13195686 |
| Web of Science KeyUT | 001332846600001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm13195686 |
| JaLCDOI | 10.18926/AMO/67667 |
|---|---|
| FullText URL | 78_5_423.pdf |
| Author | Sakamoto, Shinya| Tabuchi, Motoyasu| Yoshimatsu, Rika| Hishida, Ai| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| Abstract | Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia, is usually observed in children and infants, although more recently adult-onset nesidioblastosis has also been described. We present a case of nesidioblastosis in a 78-year-old man that was detected by 111In-pentetreotide single photon emission computed tomography (SPECT/CT). The patient was transferred to our hospital’s emergency department in a hypoglycemic coma. Dynamic enhanced CT could detect no lesion in the pancreas, but an 111In-pentetreotide SPECT/CT scan performed after a similar episode four weeks later showed increased focal uptake at the head of the pancreas. The results of a selective arterial calcium injection test were negative. After careful consideration and discussion among colleagues, surgical intervention was selected, and a pancreaticoduodenectomy was performed. On histology, there were elevated numbers of Langerhans islets in the pancreatic head, and the islets themselves appeared enlarged. Hypertrophic β-cells comprised the majority, but α-cells, δ-cells and pancreatic polypeptide were also detected in the islets. Based on the histopathological results and repeated hyperinsulinemic hypoglycemic crises, the patient was finally diagnosed with adult-onset nesidioblastosis. He had no hypoglycemic symptoms during outpatient follow-up examination. Since 111In-pentetreotide SPECT/CT may be able to detect nesidioblastosis, clinicians should consider this relatively new-modality examination when encountering such cases. |
| Keywords | 111In-pentetreotide nesidioblastosis single-photon emission computed tomography hyperinsulinemic hypoglycemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-10 |
| Volume | volume78 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 423 |
| End Page | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39467661 |
| Web of Science KeyUT | 001343346400009 |
