result 242 件
| FullText URL | fulltext.pdf suppl.pptx |
|---|---|
| Author | Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Okazaki, Yuki| Kawada, Koki| Hasegawa, Tsubasa| Ozaki, Toshifumi| |
| Keywords | medial meniscus posterior root tear pullout repair rehabilitation second‐look arthroscopy |
| Published Date | 2025-04 |
| Publication Title | Journal of Experimental Orthopaedics |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | e70139 |
| ISSN | 2197-1153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40170707 |
| DOI | 10.1002/jeo2.70139 |
| Web of Science KeyUT | 001456697900001 |
| Related Url | isVersionOf https://doi.org/10.1002/jeo2.70139 |
| JaLCDOI | 10.18926/AMO/69148 |
|---|---|
| FullText URL | 79_4_231.pdf |
| Author | Kardan, M Enes | Erdem, Ilknur| Yildiz, Emre| Kiraz, Nuri| Çelikkol, Aliye| |
| Abstract | Bloodstream infections (BSIs) are an important cause of morbidity and mortality in geriatric patients. We retrospectively analyzed the cases of geriatric patients who developed BSIs due to gram-negative bacteria in order to evaluate the epidemiology, antimicrobial resistance, and the factors affecting mortality. The cases of 110 patients aged ≥ 65 years admitted to our hospital between January 1, 2017, and December 31, 2022 were assessed; 70 (63.6%) of the BSIs were healthcare-associated BSIs. The urinary system was the most common detectable source of infection at 43.6%. The most frequently isolated bacteria were Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, in that order. Carbapenem resistance was detected in 17 patients (15.5%), and extended-spectrum beta-lactamase (ESBL) production from Enterobacterales family members was detected in 37 (51.4%) patients. Multivariate analysis revealed that (i) the probability of mortality in the patients with total bilirubin was increased by approx. sixfold and (ii) the likelihood of mortality for those with a Pitt bacteremia score (PBS) ≥ 4 points was approx. 17 times higher. PBS and simplified qPitt scores can help predict mortality and manage geriatric patients. There is a significant increase in mortality among patients with procalcitonin (PCT) levels at ≥ 2 nm/ml. |
| Keywords | geriatrics gram-negative bacteria epidemiology antimicrobial resistance mortality |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 231 |
| End Page | 242 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okazaki, Yuki| Sugiu, Kazuhisa| Kamatsuki, Yusuke| Tamura, Masanori| Kawada, Koki| Hasegawa, Tsubasa| Furumatsu, Takayuki| |
| Keywords | clinical outcome medial meniscus posterior root tear mid‐term follow‐up survival rate transtibial pullout repair |
| Published Date | 2025-04 |
| Publication Title | Journal of Experimental Orthopaedics |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | e70262 |
| ISSN | 2197-1153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40337670 |
| DOI | 10.1002/jeo2.70262 |
| Web of Science KeyUT | 001482559500001 |
| Related Url | isVersionOf https://doi.org/10.1002/jeo2.70262 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Horita, Masahiro| Saiga, Kenta| Fujiwara, Tomohiro| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | Morton neuroma T1-weighted MRI forefoot pain slug sign |
| Published Date | 2024-08-26 |
| Publication Title | Foot & Ankle Orthopaedics |
| Volume | volume9 |
| Issue | issue3 |
| Publisher | SAGE Publications |
| ISSN | 2473-0114 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39193453 |
| DOI | 10.1177/24730114241268285 |
| Related Url | isVersionOf https://doi.org/10.1177/24730114241268285 |
| JaLCDOI | 10.18926/AMO/68725 |
|---|---|
| FullText URL | 79_3_177.pdf |
| Author | Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro| |
| Abstract | The position attained in total hip arthroplasty (THA) is ideally in the center of the horizontal plane of the acetabulum. However, central placement is not always possible. We hypothesized that differences in approach result in individual differences in cup positioning; thus, we investigated the cup positions of 217 hips that underwent THA. The acetabulum’s anteroposterior diameter was measured, and the cups placed within 2 mm of the line perpendicular to the center as a central placement (central). Of the 217 hips, 68, 114, and 35 hips were anterior, central, and posterior, respectively. In 21 hips, anteroposterior deviation was noted. Among patients operated using the anterolateral approach, 48, 93, and 30 hips were anterior, central, and posterior, respectively. Among those operated using the posterolateral approach, 16, 20, and 4 hips were anterior, central, and posterior, respectively. The cup position shifted either anteriorly or posteriorly to the acetabulum in approximately half of all hips operated using both approaches and tended to shift anteriorly in the hips operated using the posterolateral approach. During THA surgery, it is important to operate with awareness of the center of the acetabulum. |
| Keywords | total hip arthroplasty cup horizontal position total hip arthroplasty approach navigation system computed tomography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 184 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68651 |
|---|---|
| FullText URL | 79_2_123.pdf |
| Author | Akatsuka, Riku| Kimura, Shuhei| Matoba, Ryo| Morizane Hosokawa, Mio| Shiode, Yusuke| Morita, Tetsuro| Doi, Shinichiro| Morizane, Yuki| |
| Abstract | A 78-year-old woman presented with sudden vision loss and central scotoma. Visual acuity in the right eye was 20/222, with submacular hemorrhage (SMH) and Henle fiber layer hemorrhage (HFLh) due to retinal arterial macroaneurysm (RAM) rupture. She underwent SMH displacement, including cataract surgery, vitrectomy, intravitreal injection of tissue-plasminogen activator, and air tamponade. Three months postoperatively the SMH and HFLh had disappeared and visual acuity had improved to 20/200. Six months postoperatively, a macular hole had developed. We performed an inverted internal limiting membrane flap and gas tamponade. Ten months later, the hole had closed and visual acuity had improved to 20/100. |
| Keywords | submacular hemorrhage Henle fiber layer hemorrhage retinal arterial macroaneurysm rupture macular hole inverted internal limiting membrane flap technique |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302284 |
| Web of Science KeyUT | 001485544200008 |
| JaLCDOI | 10.18926/AMO/68644 |
|---|---|
| FullText URL | 79_2_065.pdf |
| Author | Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka| |
| Abstract | Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy. |
| Keywords | anamorelin cancer-associated cachexia body mass index albumin efficacy rate |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 73 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302277 |
| Web of Science KeyUT | 001485544200001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Ryosuke| Matsumoto, Kazuyuki| Uka, Mayu| Takagi, Kosei| Nishida, Kenji| Tanaka, Takehiro| Fujii, Yuki| Tsutsumi, Koichiro| Horiguchi, Shigeru| Otsuka, Motoyuki| |
| Keywords | Pancreatic intraductal neoplasms Pancreatic carcinoma Intraductal tubulopapillary neoplasm Genetic testing |
| Note | The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-025-02098-y| |
| Published Date | 2025-02-05 |
| Publication Title | Clinical Journal of Gastroenterology |
| Volume | volume18 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 376 |
| End Page | 382 |
| ISSN | 1865-7257 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 39910028 |
| DOI | 10.1007/s12328-025-02098-y |
| Web of Science KeyUT | 001415187700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s12328-025-02098-y |
| JaLCDOI | 10.18926/AMO/68354 |
|---|---|
| FullText URL | 79_1_009.pdf |
| Author | Ikeya, Nanami| Okita, Atsushi| Hashida, Shinsuke| Yamamoto, Sumiharu| Ikeda, Hirokuni| Tsukuda, Kazunori| Toyooka, Shinichi| |
| Abstract | Muscle loss negatively affects gastrectomy prognosis. However, muscle loss is recognized as a systemic change, and individual muscle function is often overlooked. We investigated changes in the muscle volume of individual muscles after gastrectomy to identify clues for prognostic factors and optimal rehabilitation programs. Patients who underwent R0 gastrectomy for Stage I gastric cancer at our hospital from 2015 to 2021 were retrospectively selected to minimize the effects of malignancy and chemotherapy. Trunk muscle volume was measured by computed tomography to analyze body composition changes. Statistical analysis was performed to identify risk factors related to body composition changes. We compared the preoperative and 6-month postoperative conditions of 59 patients after gastrectomy. There was no difference in the psoas major muscle, a conventional surrogate marker of sarcopenia. There were significant decreases in the erector spinae (p=0.01) and lateral abdominal (p=0.01) muscles, and a significant increase in the rectus abdominis muscle (p=0.02). No significant correlation was found between these muscle changes and nutritional status. Body composition imbalance may serve as a new indicator of the general condition of patients after gastrectomy. Rehabilitation to correct this imbalance may improve prognosis after gastrectomy. |
| Keywords | sarcopenia skeletal muscle gastric cancer gastrectomy erector spinae muscle |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012155 |
| Web of Science KeyUT | 001440463800002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Uchida, Daisuke| Takeuchi, Yasuto| Kato, Hironari| Fujii, Yuki| Harada, Kei| Hattori, Nao| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Horiguchi, Shigeru| Tsutsumi, Koichiro| Yasui, Kazuya| Harada, Ryo| Fujii, Masakuni| Otsuka, Motoyuki| |
| Keywords | ablation techniques endosonography neuroendocrine tumors pancreatic neoplasms pilot projects |
| Published Date | 2025-01-29 |
| Publication Title | DEN Open |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70073 |
| ISSN | 2692-4609 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39885893 |
| DOI | 10.1002/deo2.70073 |
| Web of Science KeyUT | 001408662000001 |
| Related Url | isVersionOf https://doi.org/10.1002/deo2.70073 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawada, Koki| Yokoyama, Yusuke| Okazaki, Yuki| Tamura, Masanori| Ozaki, Toshifumi| Furumatsu, Takayuki| |
| Keywords | healing status lateral wedge insole meniscus extrusion osteoarthritis posterior root tear |
| Published Date | 2025-01-20 |
| Publication Title | Journal of Experimental Orthopaedics |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70141 |
| ISSN | 2197-1153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39839858 |
| DOI | 10.1002/jeo2.70141 |
| Web of Science KeyUT | 001400205300001 |
| Related Url | isVersionOf https://doi.org/10.1002/jeo2.70141 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hayashida, Tomohiro| Kuroko, Yosuke| Shimizu, Shuji| Akiyama, Tsuyoshi| Suezawa, Takanori| Kioka, Yukio| Kotani, Yasuhiro| Shishido, Toshiaki| Kasahara, Shingo| |
| Keywords | Sodium-glucose-cotransporter 2 inhibitor Dapagliflozin Myocardial ischemia/reperfusion Cardiac microdialysis Myoglobin |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-67195-3| |
| Published Date | 2024-07-16 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 16337 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39014025 |
| DOI | 10.1038/s41598-024-67195-3 |
| Web of Science KeyUT | 001337302400031 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-67195-3 |
| FullText URL | fulltext20240904-02.pdf |
|---|---|
| Author | Asanuma, Masato| Miyazaki, Ikuko| Funada, Masahiko| |
| Keywords | Psychoactive drugs 2,5-Dimethoxy-substituted phenethylamines Neurotoxicity Serotonin-containing neurons Dopamine neurons Reactive oxygen species |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11419-020-00527-w| |
| Published Date | 2020-02-21 |
| Publication Title | Forensic Toxicology |
| Volume | volume38 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 394 |
| End Page | 408 |
| ISSN | 1860-8965 |
| NCID | AA12435006 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Japanese Association of Forensic Toxicology 2020 |
| File Version | author |
| DOI | 10.1007/s11419-020-00527-w |
| Web of Science KeyUT | 000516475700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11419-020-00527-w |
| JaLCDOI | 10.18926/AMO/67204 |
|---|---|
| FullText URL | 78_3_285.pdf |
| Author | Hirano, Shuichiro| Otani, Yoshihiro| Fujii, Kentaro| Date, Isao| |
| Abstract | Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease. |
| Keywords | meningioma organized chronic subdural hematoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902217 |
| Web of Science KeyUT | 001267351900002 |
| JaLCDOI | 10.18926/AMO/67198 |
|---|---|
| FullText URL | 78_3_237.pdf |
| Author | Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi| |
| Abstract | Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period. |
| Keywords | fracture liaison services complications after admission secondary hip fracture mortality |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902211 |
| Web of Science KeyUT | 001267351000004 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| JaLCDOI | 10.18926/AMO/67196 |
|---|---|
| FullText URL | 78_3_215.pdf |
| Author | Akagawa, Takuya| Fukui, Ryohei| Kida, Katsuhiro| Matsuura, Ryutaro| Shimada, Makoto| Kinoshita, Mitsuhiro| Akagawa, Yoko| Goto, Sachiko| |
| Abstract | We propose a sitting position that achieves both high image quality and a reduced radiation dose in elbow joint imaging by area detector computed tomography (ADCT), and we compared it with the ‘superman’ and supine positions. The volumetric CT dose index (CTDIvol) for the sitting, superman, and supine positions were 2.7, 8.0, and 20.0 mGy and the dose length products (DLPs) were 43.4, 204.7, and 584.8 mGy • cm, respectively. In the task-based transfer function (TTF), the highest value was obtained for the sitting position in both bone and soft tissue images. The noise power spectrum (NPS) of bone images showed that the superman position had the lowest value up to approx. 1.1 cycles/mm or lower, whereas the sitting position had the lowest value when the NPS was greater than approx. 1.1 cycles/mm. The overall image quality in an observer study resulted in the following median Likert scores for Readers 1 and 2: 5.0 and 5.0 for the sitting position, 4.0 and 3.5 for the superman position, and 4.0 and 2.0 for the supine position. These results indicate that our proposed sitting position with ADCT of the elbow joint can provide superior image quality and allow lower radiation doses compared to the superman and supine positions. |
| Keywords | area detector computed tomography elbow joint sitting position dose reduction image quality assessment |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 215 |
| End Page | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902209 |
| Web of Science KeyUT | 001267351000002 |
| JaLCDOI | 10.18926/AMO/66930 |
|---|---|
| FullText URL | 78_2_197.pdf |
| Author | Teraishi, Fuminori| Matsumi, Yuki| Tachibana, Kota| Watanabe, Toshiyuki| Fujiwara, Toshiyoshi| |
| Abstract | A 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated severe aortic stenosis, we performed transcatheter aortic valve implantation. A radical resection was then performed with general anesthesia. The skin and subcutaneous tissue defects were reconstructed with a posterior gluteal-thigh propeller flap, and a sigmoid colostomy was created. The patient had a good postoperative course and was transferred to a rehabilitation facility 28 days after the surgery. Epidermal cysts are a common benign tumor, and clinicians should keep in mind that these cysts can become malignant. |
| Keywords | squamous cell carcinoma epidermoid cyst gluteal thigh flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688838 |
| Web of Science KeyUT | 001227932200004 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| FullText URL | 78_2_123.pdf |
| Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
