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JaLCDOI 10.18926/AMO/63207
FullText URL 76_1_41.pdf
Author Miyahara, Hiroyuki| Miyai, Takayuki| Aya, Kunihiko| Tsukahara, Hirokazu|
Abstract High-dose steroids are required for the treatment of minimal change nephrotic syndrome (MCNS), especially for episodes of recurrence. Predicting and avoiding recurrence can help reduce the steroid dose, but prediction is currently difficult. We herein examined whether changes in laboratory data, especially the urinary protein- to-creatinine ratio (UTP/UCr), can predict clinical recurrence. We also assessed differences in clinical features between children and young adults. We included 36 patients with MCNS; for each case, we retrospectively studied laboratory data during stable remission and pre-recurrence, with the “stable” period defined as all but the 6 weeks before recurrence, and pre-recurrence defined as the 4±2 weeks before recurrence. UTP/UCr, serum albumin, etc. were measured every 5 years during stable periods. We divided patients into cohorts by age at recurrence, < 15 years and ≥ 15 years, and compared stable and pre-recurrence values for the two groups. UTP/UCr values during stable periods tended to be higher in younger patients. UTP/UCr and serum albumin showed statistically significant changes during pre-recurrence periods, but only in those aged ≥ 15 years. Thus, clinical features of recurrence differed depending on age. Signs of recurrence can be confirmed via UTP/UCr or serum albumin several weeks before recurrence in patients ≥ 15 years.
Keywords minimal change nephrotic syndrome recurrence urinary protein to creatinine ratio
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 41
End Page 49
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236997
Web of Science KeyUT 000762812700006
JaLCDOI 10.18926/AMO/63206
FullText URL 76_1_33.pdf
Author Zhou, Jia-Yi| Hou, Hai-Tao| Wang, Shi-Fu| Yang, Qin| He, Guo-Wei|
Abstract Trace elements selenium (Se) and cobalt (Co) are essential in the human body, and a correlation between Se and cardiac surgery has been suggested. We investigated the plasma concentrations of Se and Co during and after coronary artery bypass grafting (CABG) surgery under cardiopulmonary bypass (CPB). From December 2019 to January 2020, preoperative plasma samples from isolated first-time CABG patients (n=20; 10 males, 10 females) were prospectively collected post-anesthesia and before CPB (T1), 45 min after CPB started (T2), 90 min after CPB started (T3), and postoperative days 1 (T4), and day 4 (T5). The plasma concentrations of Se and Co were measured. The Se concentration was significantly decreased at T2 (105.24±4.08 vs. 68.56±2.42 μg/L, p<0.001) and T3 (105.24±4.08 vs. 80.41±3.40 μg/L, p<0.001). The Co concentration was significantly decreased at T4 (0.35±0.19 vs. 0.26±0.13 μg/L, p<0.01) and T5 (0.35±0.19 vs. 0.23±0.11 μg/L, p<0.001). Five patients developed atrial fibrillation (AF); there was no other operative mortality or major morbidity. This is the first report of alterations of plasma Se and Co concentrations during and after CABG surgery. Our results may indicate that Se supplementation before or during CABG and Co supplementation after CABG may become necessary for patients undergoing CABG.
Keywords trace element CABG cardiopulmonary bypass selenium cobalt
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 39
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236996
Web of Science KeyUT 000762812700005
JaLCDOI 10.18926/AMO/63205
FullText URL 76_1_25.pdf
Author Sugimoto, Kohei| Kuroda, Masahiro| Yoshimura, Yuuki| Hamada, Kentaro| Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Konishi, Kohei| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E. | Kamizaki, Ryo| Kanazawa, Susumu| Asaumi, Junichi|
Abstract The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM.
Keywords apparent diffusion coefficient apparent diffusion coefficient subtraction method diffusion kurtosis imaging restricted diffusion short-time imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 25
End Page 32
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236995
Web of Science KeyUT 000762812700004
JaLCDOI 10.18926/AMO/63204
FullText URL 76_1_17.pdf
Author Fujishita, Keigo| Yasuhisa, Sando| Oka, Satoshi| Fujisawa, Yuka| Machida, Takuya| Imai, Toshi|
Abstract R-CHOP therapy is generally performed every 3 weeks. We investigated the effects of extending the interval of R-CHOP therapy for > 1 week on the prognoses of patients with non-indolent non-Hodgkin’s B-cell lymphoma. Among the 338 patients with non-indolent non-Hodgkin’s B-cell lymphoma who received initial chemotherapy at our institution, we focused on 178 patients who received R-CHOP therapy and analyzed the outcomes of the patients stratified by the treatment intervals. The estimated 3-year overall survival (OS) for the entire population was 82.1%. Patients treated at intervals of ≥ 4 weeks were significantly older, and they had significantly longer follow-up periods and lower relative dose intensity. But the estimated 3-year OS was comparable to those treated at <4 weeks (83.3% vs. 80.5% p=0.947). In a multivariate analysis, age and the dose of anti-cancer agents had significant impacts on OS, but there was no significant relationship regarding the treatment intervals. Propensity score matching confirmed the same result. R-CHOP therapy every around 4 weeks could achieve relatively good survival in some selected patients with non-indolent non-Hodgkin’s B-cell lymphoma.
Keywords R-CHOP therapy relative dose intensity non-Hodgkin’s lymphoma
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 17
End Page 24
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236994
Web of Science KeyUT 000762812700003
JaLCDOI 10.18926/AMO/63203
FullText URL 76_1_7.pdf
Author Takami, Masao| Yamamoto, Koichiro| Hanayama, Yoshihisa| Nakano, Yasuhiro| Hasegawa, Kou| Obika, Mikako| Hagiya, Hideharu| Furukawa, Masanori| Otsuka, Fumio|
Abstract Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.
Keywords aging renal function cholesterol subclinical hypothyroidism thyroid function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236993
Web of Science KeyUT 000762812700002
JaLCDOI 10.18926/AMO/63202
FullText URL 76_1_1.pdf
Author Takao, Tomoka| Yamada, Daisuke| Takarada, Takeshi|
Abstract Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy.
Keywords optogenetics Cre recombinase
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236992
Web of Science KeyUT 000762812700001
FullText URL fulltext20220216-4.pdf
Author Nomura, Emi| Kawahara, Yuko| Omote, Yoshio| Takahashi, Yoshiaki| Matsumoto, Namiko| Ikegami, Ken| Takemoto, Mami| Hishikawa, Nozomi| Nakano, Yumiko| Yunoki, Taijun| Morihara, Ryuta| Uemura, Masahiro| Abe, Koji| Yamashita, Toru|
Keywords ATP-binding cassette subfamily C member 6 (ABCC6) neurovascular diseases pseudoxanthoma elasticum (PXE)
Note This is the peer reviewed version of the following article: [Nomura, E, Kawahara, Y, Omote, Y, et al. A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages. Neurol Clin Neurosci. 2022; 00: 1– 4. doi:10.1111/ncn3.12575], which has been published in final form at https://doi.org/10.1111/ncn3.12575. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2022-2-4
Publication Title Neurology and Clinical Neuroscience
Volume volume10
Publisher Wiley
Start Page 98
End Page 101
ISSN 2049-4173
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1111/ncn3.12575
Web of Science KeyUT 000750987400001
Related Url isVerisonOf https://doi.org/10.1111/ncn3.12575
FullText URL fulltext.pdf
Author Nagasaki, Joji| Inozume, Takashi| Sax, Nicolas| Ariyasu, Ryo| Ishikawa, Masakazu| Yamashita, Kazuo| Kawazu, Masahito| Ueno, Toshihide| Irie, Takuma| Tanji, Etsuko| Morinaga, Takao| Honobe, Akiko| Ohnuma, Takehiro| Yoshino, Mitsuru| Iwata, Takekazu| Kawase, Katsushige| Sasaki, Keita| Hanazawa, Toyoyuki| Kochin, Vitaly| Kawamura, Tatsuyoshi| Matsue, Hiroyuki| Hino, Masayuki| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke|
Published Date 2022-02-01
Publication Title Cell Reports
Volume volume38
Issue issue5
Publisher Cell Press
Start Page 110331
ISSN 2211-1247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35108529
DOI 10.1016/j.celrep.2022.110331
NAID 120007192058
Web of Science KeyUT 000750983700001
Related Url isVersionOf https://doi.org/10.1016/j.celrep.2022.110331
FullText URL fulltext.pdf
Author Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki|
Keywords Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy
Published Date 2022-02-07
Publication Title Respiratory Research
Volume volume23
Issue issue1
Publisher BMC
Start Page 20
ISSN 1465-993X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35130915
DOI 10.1186/s12931-022-01940-y
Web of Science KeyUT 000752386100002
Related Url isVersionOf https://doi.org/10.1186/s12931-022-01940-y
FullText URL fulltext.pdf
Author Fujita, Claudia| Akhtar, M. Shahbaz| Hidaka, Ray| Nishigaki, Makoto|
Keywords Dissolved iron removal Chemical clogging Open-loop geothermal systems Retention potential Wooden charcoal
Published Date 2022-02-07
Publication Title Applied Water Science
Volume volume12
Issue issue3
Publisher SPRINGER HEIDELBERG
Start Page 30
ISSN 2190-5487
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
DOI 10.1007/s13201-022-01574-x
Web of Science KeyUT 000752014000004
Related Url isVersionOf https://doi.org/10.1007/s13201-022-01574-x
FullText URL fulltext.pdf
Author Oda, Shinsuke| Fujisawa, Masayoshi| Li, Chunning| Ito, Toshihiro| Yamaguchi, Takahiro| Yoshimura, Teizo| Matsukawa, Akihiro|
Published Date 2021-11-24
Publication Title Plos One
Volume volume16
Issue issue11
Publisher Public Library Science
Start Page e0254289
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Oda et al.
File Version publisher
PubMed ID 34818323
DOI 10.1371/journal.pone.0254289
Web of Science KeyUT 000747234800004
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0254289
FullText URL fulltext20220216-3.pdf Figure20220216-3.pdf Supplementary Figure20220216-3.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Keitoku, Koichi| Koyama, Toshihiro| Otsuka, Fumio|
Note © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ajic.2021.08.033] .|
Published Date 2022-01-28
Publication Title American Journal of Infection Control
Volume volume50
Issue issue2
Publisher Elsevier BV
Start Page 141
End Page 147
ISSN 0196-6553
NCID AA10617749
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Association for Professionals in Infection Control and Epidemiology, Inc.
File Version author
PubMed ID 34718066
DOI 10.1016/j.ajic.2021.08.033
Web of Science KeyUT 000749317500004
Related Url isVersionOf https://doi.org/10.1016/j.ajic.2021.08.033
FullText URL fulltext20220216-2.pdf
Author Thi Cam, Nguyen| Sunagawa, Naomichi| Sesumi, Miho| Kitamura, Yoshikuni| Tanaka, Yoshiyuki| Goto, Tanjuro| Yasuba, Ken-ichiro| Yoshida, Yuichi|
Published Date 2022-01-22
Publication Title The Horticulture Journal
Volume volume91
Issue issue1
Publisher Japanese Society for Horticultural Science
Start Page 58
End Page 67
ISSN 2189-0102
NCID AA12708073
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society for Horticultural Science (JSHS)
File Version publisher
DOI 10.2503/hortj.utd-315
NAID 120007193740
Web of Science KeyUT 000749466800001
Related Url isVersionOf https://doi.org/10.2503/hortj.utd-315
FullText URL fulltext20220216-1.pdf
Author Khan, Haris Ahmed| Sato, Yukiyo| Kondo, Hideki| Jamal, Atif| Bhatti, Muhammad Faraz| Suzuki, Nobuhiro|
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00705-021-05304-7|
Published Date 2022-02-03
Publication Title Archives of Virology
Volume volume167
Publisher Springer Science and Business Media LLC
Start Page 923
End Page 929
ISSN 0304-8608
NCID AA00548901
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022
File Version author
PubMed ID 35112205
DOI 10.1007/s00705-021-05304-7
Web of Science KeyUT 000749980300010
Related Url isVersionOf 1https://doi.org/0.1007/s00705-021-05304-7
FullText URL fulltext20220208-1.pdf
Author Onishi, Yasuhiro| Mise, Koki| Kawakita, Chieko| Uchida, Haruhito A.| Sugiyama, Hitoshi| Sugawara, Ryosuke| Yamaguchi, Satoshi| Yoshida, Michihiro| Mitsuhashi, Toshiharu| Yamada, Masao| Hirabayashi, Jun| Wada, Jun|
Keywords Glomerulonephritis IgA nephropathy Diagnostic biomarkers Lectins Glycomics
Note This is an Accepted Manuscript published by S. Karger AG.|
Published Date 2021-12-29
Publication Title American Journal of Nephrology
Volume volume53
Issue issue1
Publisher S. Karger AG
Start Page 10
End Page 20
ISSN 0250-8095
NCID AA10424676
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 S. Karger AG, Basel
File Version author
PubMed ID 34965524
DOI 10.1159/000520998
Web of Science KeyUT 000747743400001
Related Url isVersionOf https://doi.org/10.1159/000520998
Title Alternative Report of the 39th Annual Meeting of the Japanese Liver Transplantation Society
FullText URL 133_200.pdf
Author Yagi, Takahito|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 200
End Page 201
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.200
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.200
Title Alternative The 45th Annual Meeting of the Japanese Society of Lymphology
FullText URL 133_198.pdf
Author Kimata, Yoshihiro|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 198
End Page 199
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.198
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.198
NAID 130008139620
Title Alternative Telemedicine in cardiovascular surgery
FullText URL 133_195.pdf
Author Kasahara, Shingo|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 195
End Page 197
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.195
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.195
Title Alternative Drug interaction (52. Drug interaction with diuretics)
FullText URL 133_189.pdf
Author Takeda, Tatsuaki| Esumi, Satoru| Murakawa, Kiminaka|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 189
End Page 194
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.189
language English
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.189
Title Alternative AI research in dentistry and related clinical-study design
FullText URL 133_184.pdf
Author Kimura-Ono, Aya| Kuboki, Takuo|
Keywords 人工知能 歯科 臨床研究デザイン
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 184
End Page 188
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.184
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.184
NAID 130008139622