result 38 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Eguchi, Takanori| Sogawa, Chiharu| Ono, Kisho| Matsumoto, Masaki| Manh Tien, Tran| Okusha, Yuka| Lang, Benjamin J.| Okamoto, Kuniaki| Calderwood, Stuart K.| |
| Keywords | cell stress response stressome extracellular vesicle heat shock protein 90 (HSP90) cell division control 37 (CDC37) prostate cancer exosome ectosome |
| Published Date | 2020-03-19 |
| Publication Title | Cells |
| Volume | volume9 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 755 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32204513 |
| DOI | 10.3390/cells9030755 |
| Web of Science KeyUT | 000529337400232 |
| Related Url | isVersionOf https://doi.org/10.3390/cells9030755 |
| JaLCDOI | 10.18926/AMO/57372 |
|---|---|
| FullText URL | 73_5_419.pdf |
| Author | Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo| |
| Abstract | We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis. |
| Keywords | sedentary behavior hemodialysis mortality physical activity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 419 |
| End Page | 425 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649368 |
| Web of Science KeyUT | 000491886600007 |
| JaLCDOI | 10.18926/AMO/56932 |
|---|---|
| FullText URL | 73_4_307.pdf |
| Author | Takahashi, Sho| Akagi, Teiji| Toh, Norihisa| Takaya, Yoichi| Nakagawa, Koji| Nishii, Nobuhiro| Ito, Hiroshi| |
| Abstract | The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients’ appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease complexity and cardiovascular events, we performed univariate and multivariate survival analyses. The Simple, moderate, and complex disease groups accounted for 62%, 19%, and 19% of the patients, respectively. Apart from events related to atrial septal defect (ASD) trans-catheter treatment, the frequency of cardiovascular events was dependent on the disease complexity (event-free survival rates at 3 years were 85%, 65%, and 58%, respectively). The hazard ratios were 4.0 and 5.1 in the moderate and complex groups, respectively. With the exception of scheduled transcatheter intervention, cardiovascular events were strongly related to the disease complexity of original heart disease. However, cardiovascular events were not rare even in the simple ACHD group. |
| Keywords | congenital heart defect congenital in adults hospitalization cardiovascular event |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 313 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439953 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| FullText URL | 73_4_285.pdf |
| Author | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| Keywords | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439951 |
| Author | Inada, Ryo| Nagasaka, Takeshi| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/OER/48990 |
|---|---|
| Title Alternative | J. H. Clapham, An Economic History of Modern Britain, vol. 1, Book 1, Britain on the Eve of the Railway Age, 1820-1850 （1st ed., 1926, 2nd ed. with corrections, 1939） Outline, Chap. 8 |
| FullText URL | oer_044_2_025_038.pdf |
| Author | Ichinose, Atsushi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2012-10-01 |
| Volume | volume44 |
| Issue | issue2 |
| Start Page | 25 |
| End Page | 38 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2012 岡山大学経済学会 |
| File Version | publisher |
| NAID | 40019465601 |
| JaLCDOI | 10.18926/OER/48593 |
|---|---|
| Title Alternative | J. H. Clapham, An Economic History of Modern Britain, vol. 1, Book 1, Britain on the Eve of the Railway Age, 1820-1850 (1926), Outline, Chap. 6, Chap. 7 |
| FullText URL | oer_044_1_013_031.pdf |
| Author | Ichinose, Atsushi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2012-07-10 |
| Volume | volume44 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 31 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2012 岡山大学経済学会 |
| File Version | publisher |
| NAID | 40019387115 |
| JaLCDOI | 10.18926/OER/48232 |
|---|---|
| Title Alternative | J. H. Clapham, An Economic History of Modern Britain, vol. 1, Britain on the Eve of the Railway Age, 1820-1850（1926）, Outline, Chap. 5 |
| FullText URL | oer_043_4_051_063.pdf.pdf |
| Author | Ichinose, Atsushi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2012-03-15 |
| Volume | volume43 |
| Issue | issue4 |
| Start Page | 51 |
| End Page | 63 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2012 岡山大学経済学会 |
| File Version | publisher |
| NAID | 40019237901 |
| JaLCDOI | 10.18926/OER/47077 |
|---|---|
| Title Alternative | J. H. Clapham, An Economic History of Modern Britain, vol.1, Britain on the Eve of the Railway Age, 1820−1850（1926）, Outline |
| FullText URL | oer_043_2_045_063.pdf |
| Author | Ichinose, Atsushi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2011-09-26 |
| Volume | volume43 |
| Issue | issue2 |
| Start Page | 45 |
| End Page | 63 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2011 岡山大学経済学会 |
| File Version | publisher |
| NAID | 40018962707 |
| Author | Duda, L C| Schmitt, T| Mangnuson, M| Forsberg, J| Olsson, A| Nordgren, J.| Okada, K| Kotani, A| |
|---|---|
| Published Date | 2006-2 |
| Publication Title | Physical Review Letters |
| Volume | volume96 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Hosoya, Shigee| |
|---|---|
| Published Date | 1991-10 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue9-10 |
| Content Type | Journal Article |
| Author | Maeta, Masato| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Indo, Shunju| |
|---|---|
| Published Date | 1992-12 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume104 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Ueda, Yuzo| |
|---|---|
| Published Date | 1992-08 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume104 |
| Issue | issue7-8 |
| Content Type | Journal Article |
| Author | Tanaka, Seiryou| |
|---|---|
| Published Date | 1993-08 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume105 |
| Issue | issue7-8 |
| Content Type | Journal Article |
| Author | Sezaki, Hiroyuki| |
|---|---|
| Published Date | 2000-12-25 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume112 |
| Issue | issue9-12 |
| Content Type | Journal Article |
| Author | Gunduz, Mehmet| |
|---|---|
| Published Date | 2003-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume114 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 阪口 義彦| 林 哲也| 黒川 顕| 中山 恵介| 大島 健志郎| 藤永 由佳子| 大西 真| 大坪 栄一| 服部 正平| 小熊 惠二| |
|---|---|
| Published Date | 2007-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume118 |
| Issue | issue3 |
| Content Type | Journal Article |
