result 849 件
| Author | Shimzu, K.| Takahashi, T.| Iwasaki, T.| Shimizu, H.| Inoue, K.| Morimatsu, H.| Omori, E.| Matsumi, M.| Akagi, R.| Morita, K.| |
|---|---|
| Published Date | 2008-11 |
| Publication Title | Medicinal Chemistry |
| Volume | volume4 |
| Issue | issue6 |
| Content Type | Journal Article |
| FullText URL | AnalyticalMethods_5_11_2854-2859.pdf |
|---|---|
| Author | Inoue, Genki| Kaneta, Takashi| Takayanagi, Toshio| Kakehi, Junichi| Motose, Hiroyasu| Takahashi, Taku| |
| Published Date | 2013-05 |
| Publication Title | Analytical Methods |
| Volume | volume5 |
| Issue | issue11 |
| Publisher | RSC Publishing |
| Start Page | 2854 |
| End Page | 2859 |
| ISSN | 1759-9660 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©The Royal Society of Chemistry 2013 |
| File Version | author |
| DOI | 10.1039/C3AY26360F |
| Web of Science KeyUT | 000319004800030 |
| Related Url | isVersionOf https://doi.org/10.1039/C3AY26360F |
| FullText URL | JChromatographyA_1288_149-154.pdf |
|---|---|
| Author | Yamaguchi, Kaori| Takeyasu, Nobuyuki| Kaneta, Takashi| |
| Keywords | Capillary electrophoresis 5 '-Guanosine monophosphate (GMP) G-gel Association constant |
| Published Date | 2013-05-03 |
| Publication Title | Journal of Chromatography A |
| Volume | volume1288 |
| Publisher | Elsevier Science B.V. |
| Start Page | 149 |
| End Page | 154 |
| ISSN | 00219673 |
| NCID | AA10985833 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | (C) 2013 Elsevier B.V. All rights reserved. |
| File Version | author |
| PubMed ID | 23522259 |
| DOI | 10.1016/j.chroma.2013.02.090 |
| Web of Science KeyUT | 000317707900017 |
| Related Url | isVersionOf https://doi.org/10.1016/j.chroma.2013.02.090 |
| Author | Snyderwine, Elizabeth G.| Davis, Cindy D.| Nouso, Kazuhiro| RoIler, Peter P.| Schut, Herman A.J.| |
|---|---|
| Published Date | 1993-07 |
| Publication Title | Carcinogenesis |
| Volume | volume14 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Gotoh, Kazuma| Ishikawa, Toru| Shimadzu, Saori| Yabuuchi, Naoaki| Komaba, Shinichi| Takeda, Kazuyuki| Goto, Atsushi| Deguchi, Kenzo| Ohki, Shinobu| Hashi, Kenjiro| Shimizu, Tadashi| Ishida, Hiroyuki| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Journal of Power Sources |
| Volume | volume225 |
| Content Type | Journal Article |
| Author | Kanehara, Masayuki| Takeya, Jun| Uemura, Takafumi| Murata, Hideyuki| Takimiya, Kazuo| Sekine, Hikaru| Teranishi, Toshiharu| |
|---|---|
| Published Date | 2012-09 |
| Publication Title | Bulletin of the Chemical Society of Japan |
| Volume | volume85 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Cheng, Chao-Min| Matsuura, Koji| Wang, I-Jan| Kuroda, Yuka| LeDuc, Philip R.| Naruse, Keiji| |
|---|---|
| Published Date | 2009 |
| Publication Title | Lab on a Chip |
| Volume | volume9 |
| Issue | issue22 |
| Content Type | Journal Article |
| Author | Sakaguchi, Masakiyo| Kataoka, Ken| Abarzua, Fernando| Tanimoto, Ryuta| Watanabe, Masami| Murata, Hitoshi| Than, Swe Swe| Kurose, Kaoru| Kashiwakura, Yuji| Ochiai, Kazuhiko| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-ho| |
|---|---|
| Published Date | 2009-05-22 |
| Publication Title | The Journal of Biological Chemistry |
| Volume | volume284 |
| Issue | issue21 |
| Content Type | Journal Article |
| Author | Okazaki, H.| Arakane, T.| Sugawara, K.| Sato, T.| Takahashi, T.| Wakita, T.| Hirai, M.| Muraoka, Y.| Takano, Y.| Ishii, S.| Iriyama, S.| Kawarada, H.| Yokoya, T.| |
|---|---|
| Published Date | 2011-05-01 |
| Publication Title | Journal of Physics and Chemistry of Solids |
| Volume | volume72 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Hanaya, Tadashi| Itoh, Chika| |
|---|---|
| Published Date | 2011-03-01 |
| Publication Title | Heterocycles |
| Volume | volume82 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Yoshida, Rikiya| Nakamura, Yoshiaki| Fukui, Masaki| Haga, Yoshinori| Yamamoto, Etsuji| Ōnuki, Yoshichika| Okawa, Mario| Shin, Shik| Hirai, Masaaki| Muraoka, Yuji| Yokoya, Takayoshi| |
|---|---|
| Published Date | 2011-05-01 |
| Publication Title | Journal of Physics and Chemistry of Solids |
| Volume | volume72 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Takasaka, Kenji| Iwai, Masako| Umena, Yasufumi| Kawakami, Keisuke| Ohmori, Yukari| Ikeuchi, Masahiko| Takahashi, Yuichiro| Kamiya, Nobuo| Shen, Jian-Ren| |
|---|---|
| Published Date | 2010-02 |
| Publication Title | Biochimica et Biophysica Acta (BBA) - Bioenergetics |
| Volume | volume1797 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nagao, Ryo| Moriguchi, Akira| Tomo, Tatsuya| Niikura, Ayako| Nakajima, Saori| Suzuki, Takehiro| Okumura, Akinori| Iwai, Masako| Shen, Jian-Ren| Ikeuchi, Masahiko| Enami, Isao| |
|---|---|
| Published Date | 2010-09-17 |
| Publication Title | The Journal of Biological Chemistry |
| Volume | volume285 |
| Issue | issue38 |
| Content Type | Journal Article |
| Author | Kitamatsu, Mizuki| Sisido, Masahiko| |
|---|---|
| Published Date | 2011-04-28 |
| Publication Title | MedChemComm |
| Volume | volume2 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Matsuura, Eiji| Igarashi, Yoshiko| Yasuda, Tatsuji| Triplett, Douglas A.| Koike, Takao| |
|---|---|
| Published Date | 1994-02-01 |
| Publication Title | Journal of Experimental Medicine |
| Volume | volume179 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Mitsudo, Koichi| Shiraga, Takuya| Mizukawa, Jun-ichi| Suga, Seiji| Tanaka, Hideo| |
|---|---|
| Published Date | 2010 |
| Publication Title | Chemical Communications |
| Volume | volume46 |
| Issue | issue48 |
| Content Type | Journal Article |
| Author | Mandai, Hiroki| Irie, Shunsuke| Mitsudo, Koichi| Suga, Seiji| |
|---|---|
| Published Date | 2011-10-20 |
| Publication Title | Molecules |
| Volume | volume16 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Tanaka, Toshiyuki| Tajima, Ichirou| Kato, Yuichi| Nishihara, Yasushi| Shinjoh, Hirofumi| |
|---|---|
| Published Date | 2011-02-22 |
| Publication Title | Applied Catalysis B: Environmental |
| Volume | volume102 |
| Issue | issue3-4 |
| Content Type | Journal Article |
| Author | Nishihara, Yasushi| Saito, Daisuke| Inoue, Eiji| Okada, Yoshiaki| Miyazaki, Mikihiro| Inoue, Yoshiaki| Takagi, Kentaro| |
|---|---|
| Published Date | 2010-01-13 |
| Publication Title | Tetrahedron Letters |
| Volume | volume51 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/48076 |
|---|---|
| FullText URL | 66_1_7.pdf |
| Author | Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi| |
| Abstract | The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer. |
| Keywords | REIC Dickkopf-3 gene therapy prostate cancer preclinical study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358134 |
| Web of Science KeyUT | 000300800700002 |
