result 636 件
| JaLCDOI | 10.18926/AMO/56939 |
|---|---|
| FullText URL | 73_4_361.pdf |
| Author | Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi| |
| Abstract | A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis. |
| Keywords | phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 361 |
| End Page | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439960 |
| FullText URL | J_ClinMicrobiol_52_3_1020.pdf |
|---|---|
| Author | Ghosh, Priyanka| Naha, Arindam| Basak, Surajit| Ghosh, Santanu| Ramamurthy, T.| Koley, Hemanta| K Nandy, Ranjan| Shinoda, Sumio| Watanabe, Haruo| Mukhopadhyay, Asish K.| |
| Keywords | Cholera Vibrio cholerae tcpA El Tor |
| Note | This is an Accepted Manuscript of an article published by American Society for Microbiology| |
| Published Date | 2014-03 |
| Publication Title | Journal of Clinical Microbiology |
| Volume | volume52 |
| Issue | issue3 |
| Publisher | American Society for Microbiology |
| Start Page | 1020 |
| End Page | 1021 |
| ISSN | 00951137 |
| NCID | AA00695531 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 24371245 |
| DOI | 10.1128/JCM.03042-13 |
| Web of Science KeyUT | 000332164200053 |
| Related Url | isVersionOf https://doi.org/10.1128/JCM.03042-13 |
| FullText URL | cancers_11_6_792.pdf |
|---|---|
| Author | Eguchi, Takanori| Prince, Thomas L.| Manh Tien Tran| Sogawa, Chiharu| Lang, Benjamin J.| Calderwood, Stuart K.| |
| Keywords | SCAN zinc finger SCAND1 CDC37 MZF1 prostate cancer |
| Published Date | 2019-06 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 792 |
| ISSN | 20726694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.3390/cancers11060792 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11060792 |
| FullText URL | GJBAHS_2_3_178.pdf |
|---|---|
| Author | Ghosh, Arjun| Karmakar, Sumallya| Mukherjee, Avik K.| Raj, Dibyendu| Das, Koushik| Sarkar, Srimanti| Nozaki, T.| Ganguly, Sandipan| |
| Keywords | Giardia lamblia snRNA snoRNA U3 U14 |
| Published Date | 2013 |
| Publication Title | Global Journal of Biology, Agriculture & Health Sciences |
| Volume | volume2 |
| Issue | issue3 |
| Publisher | Longdom Publishing |
| Start Page | 178 |
| End Page | 184 |
| ISSN | 23195584 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| FullText URL | Front_Microbiol_7_1250.pdf |
|---|---|
| Author | Ghosh, Raikamal| Sharma, Naresh C.| Halder, Kalpataru| Bhadra, Rupak K.| Chowdhury, Goutam| Pazhani, Gururaja P.| Shinoda, Sumio| Mukhopadhyay, Asish K.| Nair, G. Balakrish| Ramamurthy, Thadavarayan| |
| Keywords | V.cholerae O139 ribotypes CT genotype CTX prophage PFGE |
| Published Date | 2016-08-09 |
| Publication Title | frontiers in Microbiology |
| Volume | volume7 |
| Publisher | Frontiers Media S.A. |
| Start Page | 1250 |
| ISSN | 1664302X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 27555841 |
| DOI | 10.3389/fmicb.2016.01250 |
| Web of Science KeyUT | 000381079700001 |
| Related Url | isVersionOf https://doi.org/10.3389/fmicb.2016.01250 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| FullText URL | 73_2_135.pdf |
| Author | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| Abstract | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| Keywords | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015748 |
| Title Alternative | Basic studies on S100-mediated cancer metastasis based on the development of innovative biologics to aim at its effective prevention |
|---|---|
| FullText URL | 130_135.pdf |
| Author | Sakaguchi, Masakiyo| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-12-03 |
| Volume | volume130 |
| Issue | issue3 |
| Start Page | 135 |
| End Page | 139 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.135 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.135 |
| NAID | 130007542849 |
| JaLCDOI | 10.18926/AMO/56464 |
|---|---|
| FullText URL | 73_1_85.pdf |
| Author | Abe, Yoshiyuki| Fujibayashi, Kazutoshi| Nishizaki, Yuji| Yanagisawa, Naotake| Nojiri, Shuko| Nakano, Soichiro| Tada, Kurisu| Yamaji, Ken| Tamura, Naoto| |
| Abstract | Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. |
| Keywords | pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 89 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820060 |
| JaLCDOI | 10.18926/AMO/56461 |
|---|---|
| FullText URL | 73_1_71.pdf |
| Author | Takahashi-Arimasa, Keiko| Kohno-Yamanaka, Reiko| Soga, Yoshihiko| Miura, Rumi| Morita, Manabu| |
| Abstract | Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. He could not brush his teeth by himself. However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. Interprofessional collaboration is useful especially for patients with upper limb disability. |
| Keywords | esophageal cancer preoperative oral care post-polio syndrome neoadjuvant chemotherapy oral mucositis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820057 |
| FullText URL | Nat_Plants_4_1044.pdf |
|---|---|
| Author | Takami, Tsuneaki| Ohnishi, Norikazu| Kurita, Yuko| Iwamura, Shoko| Ohnishi, Miwa| Kusaba, Makoto| Mimura, Tetsuro| Sakamoto, Wataru| |
| Note | This is an Accepted Manuscript of an article published by Springer Nature Publishing AG| |
| Published Date | 2018-05-12 |
| Publication Title | Nature Plants |
| Volume | volume4 |
| Publisher | Springer Nature Publishing AG |
| Start Page | 1044 |
| End Page | 1055 |
| ISSN | 20550278 |
| NCID | AA1273934X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30420711 |
| DOI | 10.1038/s41477-018-0291-x |
| Related Url | isVersionOf https://doi.org/10.1038/s41477-018-0291-x |
| FullText URL | Nat_Comm_9_2132.pdf |
|---|---|
| Author | Nishimura, Noriyuki| Tsuchiya, Wataru| Moresco, James J.| Hayashi, Yuki| Satoh, Kouji| Kaiwa, Nahomi| Irisa, Tomoko| Kinoshita, Toshinori| Schroeder, Julian I.| Yates III, John R.| Hirayama, Takashi| Yamazaki, Toshimasa| |
| Published Date | 2018-06-06 |
| Publication Title | Nature Communications |
| Volume | volume9 |
| Publisher | Springer Nature |
| Start Page | 2132 |
| ISSN | 2041-1723 |
| NCID | AA12645905 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 29875377 |
| DOI | 10.1038/s41467-018-04437-9 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-018-04437-9 |
| FullText URL | elife_7_35122.pdf elife_7_35122_fig.pdf |
|---|---|
| Author | Hamada, Mayuko| Schröder, Katja| Bathia, Jay| Kürn, Ulrich| Fraune, Sebastian| Khalturina, Mariia| Khalturin, Konstantin| Shinzato, Chuya| Satoh, Nori| Bosch, Thomas CG| |
| Keywords | Chlorella Hydra evolutionary biology genome nitrogen metabolism symbiosis |
| Published Date | 2018-03-31 |
| Publication Title | eLife |
| Volume | volume7 |
| Publisher | eLife Sciences Publications |
| Start Page | e35122 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 29848439 |
| DOI | 10.7554/eLife.35122 |
| Web of Science KeyUT | 000436227400001 |
| Related Url | isVersionOf https://doi.org/10.7554/eLife.35122 |
| FullText URL | K0005814_abstract_review.pdf K0005814_fulltext.pdf K0005814_fulltext_figure.pdf K0005814_summary.pdf |
|---|---|
| Author | Fujita, Shiho| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5814号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | elife_7_30246.pdf |
|---|---|
| Author | Takeda, Tetsuya| Kozai, Toshiya| Yang, Huiran| Ishikuro, Daiki| Seyama, Kaho| Kumagai, Yusuke| Abe, Tadashi| Yamada, Hiroshi| Uchihashi, Takayuki| Ando, Toshio| Takei, Kohji| |
| Keywords | EM HS-AFM amphiphysin biophysics cell biology dynamin human in vitro reconstitution membrane remodeling structural biology |
| Published Date | 2018-01 |
| Publication Title | eLife |
| Volume | volume7 |
| Publisher | eLife Sciences Publications |
| Start Page | e30246 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 29357276 |
| DOI | 10.7554/eLife.30246 |
| Web of Science KeyUT | 000423036500001 |
| Related Url | isVersionOf https://doi.org/10.7554/eLife.30246 |
| FullText URL | Mol_Cell_Biol_28_7_2391.pdf |
|---|---|
| Author | Eguchi, Takanori| Kubota, Satoshi| Kawata, Kazumi| Mukudai, Yoshiki| Uehara, Junji| Ohgawara, Toshihiro| Ibaragi, Soichiro| Sasaki, Akira| Kuboki, Takuo| Takigawa, Masaharu| |
| Published Date | 2008-04 |
| Publication Title | Molecular and Cellular Biology |
| Volume | volume28 |
| Issue | issue7 |
| Publisher | American Society for Microbiology |
| Start Page | 2391 |
| End Page | 2413 |
| ISSN | 0270-7306 |
| NCID | AA10620925 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 18172013 |
| DOI | 10.1128/MCB.01288-07 |
| Web of Science KeyUT | 000254181400025 |
| Related Url | isVersionOf https://doi.org/10.1128/MCB.01288-07 |
| JaLCDOI | 10.18926/AMO/56071 |
|---|---|
| FullText URL | 72_3_257.pdf |
| Author | Asano, Keiichi| Edamatsu, Midori| F. Hatipoglu, Omer| Inagaki, Junko| Ono, Mitsuaki| Ohtsuki, Takashi| Oohashi, Toshitaka| Hirohata, Satoshi| |
| Abstract | Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine Lewis lung carcinoma (LLC) tumors showed marked expressions of Adamts4 and Adamts5. We examined the contributions and distributions of host-derived Adamts4 and Adamts5 on tumor growth, using Adamts4LacZ/LacZ and Adamts5LacZ/LacZ knockout mice. Interestingly, the Adamts4LacZ/LacZ mice showed enhanced tumor growth compared to wild-type mice at 5-, 10- and 12-days post-inoculation, whereas the Adamts5LacZ/LacZ mice did not show significant differences in tumor growth. We next examined LacZ distribution in LLC tumor-bearing Adamts4LacZ/LacZ mice by β-galactosidase (β-gal) staining. We found that the β-gal-positive signals were strictly localized at the interior areas of the tumor at 10 days post-inoculation. Multiple staining demonstrated that most of the β-gal-positive cells were localized at the tumor vasculature in Adamts4LacZ/LacZ mice. Interestingly, β-gal-positive signals were not co-localized with biglycan after 10 days post-inoculation, excluding the biglycan cleavage by host-derived ADAMTS4. Taken together, these findings illustrate that host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. |
| Keywords | ADAMTS metalloproteinase extracellular matrix tumor microenvironment mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 257 |
| End Page | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926003 |
| FullText URL | K0005686_abstract_review.pdf K0005686_summary.pdf K0005686_fulltext.pdf K0005686_fig.pdf |
|---|---|
| Author | Nishiyama, Yuki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5686号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005677_abstract_review.pdf K0005677_summary.pdf K0005677_fulltext.pdf K0005677_other.pdf |
|---|---|
| Author | Hasegawa, Toru| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5677号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | ApplEntomolZool_53_1_63.pdf ApplEntomolZool_53_1_63_fig.pdf |
|---|---|
| Author | Okazaki, Tomoaki| Ichinose, Junya| Takebe, So| Ide, Toru| Hayakawa, Tohru| |
| Keywords | Bacillus thuringiensis Mosquitocidal Cry46Ab toxin 4AaCter-tag Formation of protein inclusion Escherichia coli |
| Note | This is an Accepted Manuscript of an article published by Springer Nature| |
| Published Date | 2018-02 |
| Publication Title | Applied Entomology and Zoology |
| Volume | volume53 |
| Issue | issue1 |
| Publisher | Springer Japan |
| Start Page | 67 |
| End Page | 73 |
| ISSN | 0003-6862 |
| NCID | AA00543238 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1007/s13355-017-0529-5 |
| Web of Science KeyUT | 000422695600008 |
| Related Url | isVersionOf https://doi.org/10.1007/s13355-017-0529-5 |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| FullText URL | 71_6_459.pdf |
| Author | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| Abstract | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| Keywords | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-12 |
| Volume | volume71 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 459 |
| End Page | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29276218 |
