result 304 件
| FullText URL | BBB_82_7_1172.pdf |
|---|---|
| Author | Uemura, Ryota| Ogura, Mikako| Matsumaru, Chihiro| Akiyama, Tsuyoshi| Maeda, Megumi| Kimura, Yoshinobu| |
| Keywords | Acidic PNGase FNG: free N-glycan Fuc: L-fucose Gal: D-galactose GlcNAc: N-acetyl-D-glucosamine HPLC: high-performance liquid chromatography Man: D-mannose NeuNAc2Gal2GlcNAc2Man3GlcNAc1: NeuNAcα2–6Galβ1–4GlcNAcβ1–2Manα1–6(NeuNAcα2–6Galβ1–4GlcNAcβ1–2Manα1–3)Manβ1–4GlcNAc NeuNAc2Gal2GlcNAc2Man3GlcNAc2: NeuNAcα2–6Galβ1–4GlcNAcβ1–2Manα1–6(NeuNAcα2–6Galβ1–4GlcNAcβ1–2Manα1–3)Manβ1–4GlcNAcβ1–4GlcNAc NeuNAc: N-acetylneuraminic acid PA-: pyridylamino PNGase-A: aPNGase from almond seed PNGase-Le: aPNGase from tomato (Solanum lycopersium L.) PNGase: peptide:N-glycanase PTC: plant complex type RCA120: Ricinus communis agglutinin (120 kDa) RP-HPLC: reversed-phase HPLC SF-HPLC: size-fractionation HPLC Xyl: D-xylose affinity chromatography enzyme assay free N-glycans transgenic plant |
| Published Date | 2018-04 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume82 |
| Issue | issue7 |
| Publisher | Taylor & Francis |
| Start Page | 1172 |
| End Page | 1175 |
| ISSN | 09168451 |
| NCID | AA10824164 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 29658432 |
| DOI | 10.1080/09168451.2018.1459464 |
| Web of Science KeyUT | 000436822900015 |
| Related Url | isVersionOf https://doi.org/10.1080/09168451.2018.1459464 |
| FullText URL | BBB_81_7_1405.pdf |
|---|---|
| Author | Tanabe, Chinatsu| Kaori, Furuta| Megumi, Maeda| Yoshinobu, Kimura| |
| Keywords | Phyllostachys edulis antigenic N-glycans bamboo shoot plant N-glycans plant glycoproteins |
| Published Date | 2017-05 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume81 |
| Issue | issue7 |
| Publisher | Taylor & Francis |
| Start Page | 1405 |
| End Page | 1408 |
| ISSN | 0916-8451 |
| NCID | AA10824164 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 28471334 |
| DOI | 10.1080/09168451.2017.1320519 |
| Web of Science KeyUT | 000402992500021 |
| Related Url | isVersionOf https://doi.org/10.1080/09168451.2017.1320519 |
| JaLCDOI | 10.18926/AMO/56071 |
|---|---|
| FullText URL | 72_3_257.pdf |
| Author | Asano, Keiichi| Edamatsu, Midori| F. Hatipoglu, Omer| Inagaki, Junko| Ono, Mitsuaki| Ohtsuki, Takashi| Oohashi, Toshitaka| Hirohata, Satoshi| |
| Abstract | Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine Lewis lung carcinoma (LLC) tumors showed marked expressions of Adamts4 and Adamts5. We examined the contributions and distributions of host-derived Adamts4 and Adamts5 on tumor growth, using Adamts4LacZ/LacZ and Adamts5LacZ/LacZ knockout mice. Interestingly, the Adamts4LacZ/LacZ mice showed enhanced tumor growth compared to wild-type mice at 5-, 10- and 12-days post-inoculation, whereas the Adamts5LacZ/LacZ mice did not show significant differences in tumor growth. We next examined LacZ distribution in LLC tumor-bearing Adamts4LacZ/LacZ mice by β-galactosidase (β-gal) staining. We found that the β-gal-positive signals were strictly localized at the interior areas of the tumor at 10 days post-inoculation. Multiple staining demonstrated that most of the β-gal-positive cells were localized at the tumor vasculature in Adamts4LacZ/LacZ mice. Interestingly, β-gal-positive signals were not co-localized with biglycan after 10 days post-inoculation, excluding the biglycan cleavage by host-derived ADAMTS4. Taken together, these findings illustrate that host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. |
| Keywords | ADAMTS metalloproteinase extracellular matrix tumor microenvironment mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 257 |
| End Page | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926003 |
| FullText URL | K0005686_abstract_review.pdf K0005686_summary.pdf K0005686_fulltext.pdf K0005686_fig.pdf |
|---|---|
| Author | Nishiyama, Yuki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5686号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005677_abstract_review.pdf K0005677_summary.pdf K0005677_fulltext.pdf K0005677_other.pdf |
|---|---|
| Author | Hasegawa, Toru| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5677号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | Mod_Rheumatol_26_6_940.pdf fig.pdf tbl.jpg fig_all.zip |
|---|---|
| Author | Hara, Chikako| Kubota, Satoshi| Nishida, Takashi| Hiasa, Miki| Hattori, Takako| Aoyama, Eriko| Moriyama, Yoshinori| Kamioka, Hiroshi| Takigawa, Masaharu| |
| Keywords | CCN family Cartilage Megakaryocyte Platelet Regeneration |
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group| This fulltext availavle in Nov 2017| |
| Published Date | 2016-11 |
| Publication Title | Modern Rheumatology |
| Volume | volume26 |
| Issue | issue6 |
| Publisher | Taylor & Francis |
| Start Page | 940 |
| End Page | 949 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26915735 |
| DOI | 10.3109/14397595.2016.1155255 |
| Web of Science KeyUT | 000393121500022 |
| Related Url | isVersionOf https://doi.org/10.3109/14397595.2016.1155255 |
| FullText URL | K0005298_other1.pdf |
|---|---|
| Author | Sakaguchi, Masakiyo| Murata, Hitoshi| Aoyama, Yumi| Hibino, Toshihiko| Widya Putranto, Endy| Winarsa Ruma, I. Made| Inoue, Yusuke| Sakaguchi, Yoshihiko| Yamamoto, Ken-ichi| Kinoshita, Rie| Futami, Junichiro| Kataoka, Ken| Iwatsuki, Keiji| Huh, Nam-ho| |
| Keywords | Cancer Cell Biology Keratinocyte Psoriasis Receptor for Advanced Glycation End Products (RAGE) |
| Note | 学位審査副論文| |
| Published Date | 2014-08 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume289 |
| Issue | issue34 |
| Publisher | American Society for Biochemistry and Molecular |
| Start Page | 23389 |
| End Page | 23402 |
| ISSN | 0021-9258 |
| NCID | AA00251083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 25002577 |
| DOI | 10.1074/jbc.M114.573071 |
| Web of Science KeyUT | 000341505000014 |
| Related Url | https://doi.org/10.1074/jbc.M114.573071 http://ousar.lib.okayama-u.ac.jp/54281 |
| FullText URL | J. Biol. Chem_292_9_3909.pdf |
|---|---|
| Author | Takeuchi, Tomoya| Harada, Yuika| Moriyama, Satomi| Furuta, Kazuyuki| Tanaka, Satoshi| Miyaji Takaaki| Omote, Hiroshi| Moriyama, Yoshinori| Hiasa, Miki| |
| Keywords | histamine mast cell polyamine secretory granules spermine transporter vesicles vesicular polyamine transporter |
| Published Date | 2017-03 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume292 |
| Issue | issue9 |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Start Page | 3909 |
| End Page | 3918 |
| ISSN | 0021-9258 |
| NCID | AA00251083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 28082679 |
| DOI | 10.1074/jbc.M116.756197 |
| Web of Science KeyUT | 000395542500031 |
| Related Url | isVersionOf https://doi.org/10.1074/jbc.M116.756197 |
| FullText URL | J. Biol. Chem_292_20_8436.pdf |
|---|---|
| Author | Horiuchi, Takahiro| Sakata, Natsumi| Narumi, Yoshihiro| Kimura, Tomohiro| Hayashi, Takashi| Nagano, Keisuke| Liu, Keyue| Nishibori, Masahiro| Tsukita, Sohei| Yamada, Tetsuya| Katagiri, Hideki| Shirakawa, Ryutaro| Horiuchi, Hisanori| |
| Keywords | cytokine inflammation liver injury metformin p38 MAPK |
| Published Date | 2017-05 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume292 |
| Issue | issue20 |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Start Page | 8436 |
| End Page | 8446 |
| ISSN | 0021-9258 |
| NCID | AA00251083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 28373282 |
| DOI | 10.1074/jbc.M116.769380 |
| Web of Science KeyUT | 000401788600027 |
| Related Url | https://doi.org/10.1074/jbc.M116.769380 |
| FullText URL | J. Biol. Chem_292_23_9599.pdf |
|---|---|
| Author | Motomura, Taiki| Suga, Michihiro| Hienerwadel, Rainer| Nakagawa, Akiko| Lai, Thanh-Lan| Nitschke, Wolfgang| Kuma, Takahiro| Sugiura, Miwa| Boussac, Alain| Shen, Jian-Ren| |
| Keywords | D1 protein His-Cys heme axial coordination PAS domain PAS-like domain Tll0287 X-ray crystallography cytochrome heme photosynthesis photosystem II |
| Published Date | 2017-06 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume292 |
| Issue | issue23 |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Start Page | 9599 |
| End Page | 9612 |
| ISSN | 0021-9258 |
| NCID | AA00251083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 28428249 |
| DOI | 10.1074/jbc.M116.746263 |
| Web of Science KeyUT | 000403113000012 |
| Related Url | isVersionOf https://doi.org/10.1074/jbc.M116.746263 |
| FullText URL | K0005469_abstract_review.pdf K0005469_summary.pdf K0005469_fulltext.pdf |
|---|---|
| Author | Komatsubara, Motoshi| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5469号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005398_abstract_review.pdf K0005398_fulltext.pdf |
|---|---|
| Author | Takeshima, Mika| |
| Published Date | 2016-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5398号 |
| Granted Date | 2016-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Murase, Yurika| |
|---|---|
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Author | Nakagawa, Tomoyuki| Mitsui, Ryoji| Tani, Akio| Sasa, Kentaro| Tashiro, Shinya| Iwama, Tomonori| Hayakawa, Takashi| Kawai, Keiichi| |
|---|---|
| Published Date | 2013-03-22 |
| Publication Title | PLOS ONE |
| Volume | volume7 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Hara, Emilio Satoshi| Ono, Mitsuaki| Eguchi, Takanori| Kubota, Satoshi| Hai, Thanh Pham| Sonoyama, Wataru| Tajima, Shoji| Takigawa, Masaharu| Stuart K., Calderwood| Kuboki, Takuo| |
|---|---|
| Published Date | 2013-12-27 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue12 |
| Content Type | Journal Article |
| FullText URL | K0005218_abstract_review.pdf K0005218_fulltext.pdf K0005218_fulltext_other.pdf |
|---|---|
| Author | Hosoya, Takeshi| |
| Published Date | 2015-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5218号 |
| Granted Date | 2015-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005217_abstract_review.pdf K0005217_fulltext.pdf |
|---|---|
| Author | Hara, Takayuki| |
| Published Date | 2015-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5217号 |
| Granted Date | 2015-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/53521 |
|---|---|
| FullText URL | 69_3_145.pdf |
| Author | Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi| |
| Abstract | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. |
| Keywords | ECP reactive oxygen species Akt ERK |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 153 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101190 |
| Web of Science KeyUT | 000356903000003 |
| Author | Miyaji, Takaaki| Kuromori, Takashi| Takeuchi, Yu| Yamaji, Naoki| Yokosho, Kengo| Shimazawa, Atsushi| Sugimoto, Eriko| Omote, Hiroshi| Ma, Jian Feng| Shinozaki, Kazuo| Moriyama, Yoshinori| |
|---|---|
| Published Date | 2015-01-05 |
| Publication Title | Nature Communications |
| Volume | volume6 |
| Content Type | Journal Article |
| FullText URL | K0005114 abstract_review.pdf K0005114_fulltext.pdf |
|---|---|
| Author | Zhang, Ran| |
| Published Date | 2015-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5114号 |
| Granted Date | 2015-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
