result 146 件
| FullText URL | Int_J_Med_Microbiol_306_8_657.pdf |
|---|---|
| Author | Chourashi, Rhishita| Mondal, Moumita| Sinha, Ritam| Debnath, Anusuya| Das, Suman| Koley, Hemanta| Sekhar Chatterjeea, Nabendu| |
| Keywords | ChiS Mucin Vibrio cholerae Virulence |
| Note | This is an Accepted Manuscript of an article published by Elsevier GmbH| |
| Published Date | 2016-12 |
| Publication Title | International Journal of Medical Microbiology |
| Volume | volume306 |
| Issue | issue8 |
| Publisher | ELSEVIER GMBH |
| Start Page | 657 |
| End Page | 665 |
| ISSN | 14384221 |
| NCID | AA11427330 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27670078 |
| DOI | 10.1016/j.ijmm.2016.09.003 |
| Web of Science KeyUT | 000390824600008 |
| Related Url | isVersionf https://doi.org/10.1016/j.ijmm.2016.09.003 |
| Title Alternative | Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system |
|---|---|
| FullText URL | poalas_034_002.pdf |
| Author | Takahashi, Sumio| |
| Abstract | Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3−⁄−) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3−⁄− mice was caused by alteration of gonadotropin secretion in Runx3−⁄− mice. Cyp11a1 mRNA expression was less in Runx3−⁄− mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3−⁄− mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3−⁄− mice. These findings suggest that anovulation in Runx3−⁄− mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion. |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Published Date | 2018-04 |
| Volume | volume34 |
| Start Page | 2 |
| End Page | 4 |
| language | Japanese |
| File Version | publisher |
| FullText URL | Reprod_Fertil_Dev_29_7_1280.pdf fig.pdf |
|---|---|
| Author | Horihata, Kei| Yoshioka, Shin| Sano, Masahiro| Yamamoto, Yuki| Kimura, Koji| Skarzynski, Dariusz J.| Okuda, Kiyoshi| |
| Keywords | luteal phase ovary progesterone prostaglandin reproduction |
| Note | This is an Accepted Manuscript of an article published by CSIRO Publishing| |
| Published Date | 2016-05-17 |
| Publication Title | Reproduction, Fertility and Development |
| Volume | volume29 |
| Issue | issue7 |
| Publisher | CSIRO Publishing |
| Start Page | 1280 |
| End Page | 1286 |
| ISSN | 10313613 |
| NCID | AA10718189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 27185011 |
| DOI | 10.1071/RD15538 |
| Web of Science KeyUT | 000403550200002 |
| Related Url | https://doi.org/10.1071/RD15538 |
| FullText URL | Reprod_Fertil_Dev_28_6_673.pdf |
|---|---|
| Author | Yamamoto, Yuki| Kohka, Misa| Kobayashi, Yoshihiko| Woclawek-Potocka, Izabela| Okuda, Kiyoshi| |
| Keywords | endothelin converting enzyme endothelin receptor epithelial cell ovarian steroids oviductal contraction and relaxation |
| Note | This is an Accepted Manuscript of an article published by CSIRO Publishing| |
| Published Date | 2014-11 |
| Publication Title | Reproduction, Fertility and Development |
| Volume | volume28 |
| Issue | issue6 |
| Publisher | CSIRO Publishing |
| Start Page | 673 |
| End Page | 681 |
| ISSN | 1031-3613 |
| NCID | AA10718189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 25370848 |
| DOI | 10.1071/RD14076 |
| Web of Science KeyUT | 000374546100003 |
| Related Url | isVersionOf https://doi.org/10.1071/RD14076 |
| FullText URL | Reprod_Fertil_Dev_29_10_1902.pdf |
|---|---|
| Author | Bui, Tra M. T.| Nguyễn, Khánh X.| Karata, Asako| Ferré, Pilar| Trần, Minh T.| Wakai, Takuya| Funahashi, Hiroaki| |
| Keywords | pig |
| Note | This is an Accepted Manuscript of an article published by CSIRO Publishing| |
| Published Date | 2016-12-12 |
| Publication Title | Reproduction, Fertility and Development |
| Volume | volume29 |
| Issue | issue10 |
| Publisher | CSIRO Publishing |
| Start Page | 1902 |
| End Page | 1909 |
| ISSN | 1031-3613 |
| NCID | AA10718189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 27938625 |
| DOI | 10.1071/RD16321 |
| Web of Science KeyUT | 000409376900003 |
| Related Url | https://doi.org/10.1071/RD16321 |
| FullText URL | K0005439_other2.pdf |
|---|---|
| Author | Onoda, Satoshi| Kimata, Yoshihiro| Matsumoto, Kumiko| Yamada, Kiyoshi| |
| Note | 学位審査副論文| |
| Published Date | 2016-01 |
| Publication Title | Plastic and Reconstructive Surgery |
| Volume | volume137 |
| Issue | issue1 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | 83e |
| End Page | 91e |
| ISSN | 00321052 |
| NCID | AA00775696 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26710064 |
| DOI | 10.1097/PRS.0000000000001884 |
| Web of Science KeyUT | 000367333300001 |
| Related Url | https://doi.org/10.1097/PRS.0000000000001884 |
| Title Alternative | Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics |
|---|---|
| FullText URL | poalas_033_015_017.pdf |
| Author | Takarada, Takeshi| |
| Abstract | Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts. |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Published Date | 2017-04 |
| Volume | volume33 |
| Start Page | 15 |
| End Page | 17 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/54499 |
|---|---|
| FullText URL | 70_4_243.pdf |
| Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
| Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549668 |
| Web of Science KeyUT | 000384748600003 |
| Author | Yamamoto, Yuki| |
|---|---|
| Published Date | 2016-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume105 |
| Content Type | Departmental Bulletin Paper |
| Author | Sakaguchi, Ei| |
|---|---|
| Published Date | 2015-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume104 |
| Content Type | Departmental Bulletin Paper |
| Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume26 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Narita, Yuichi| Kajari Karmakar| Sébastien Ducret| Filippo M. Rijli| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume30 |
| Content Type | Others |
| Author | Kosaka, Junko| Morimatsu, Hiroshi| Takahashi, Toru| Shimizu, Hiroko| Kawanishi, Susumu| Omori, Emiko| Endo, Yasumasa| Tamaki, Naofumi| Morita, Manabu| Morita, Kiyoshi| |
|---|---|
| Published Date | 2013-05-07 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Ohuchi, Hideyo| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nishikawa, Toshio| Takaoka, Munenori| Ohara, Toshiaki| Tomono, Yasuko| Hao, Huifang| Bao, Xiaohong| Fukazawa, Takuya| Wang, Zhigang| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Motoki, Takayuki| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Tanaka, Noriaki| Fujiwara, Toshiyoshi| Naomoto, Yoshio| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Cancer Biology & Therapy |
| Volume | volume14 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Shimzu, K.| Takahashi, T.| Iwasaki, T.| Shimizu, H.| Inoue, K.| Morimatsu, H.| Omori, E.| Matsumi, M.| Akagi, R.| Morita, K.| |
|---|---|
| Published Date | 2008-11 |
| Publication Title | Medicinal Chemistry |
| Volume | volume4 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Endo, Yasumasa| Tomofuji, Takaaki| Ekuni, Daisuke| Azuma, Tetsuji| Irie, Koichiro| Kasuyama, Kenta| Morita, Manabu| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | Journal of Clinical Periodontology |
| Volume | volume40 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | Critical Care Medicine |
| Volume | volume41 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kondo, Yasuhiro| |
|---|---|
| Published Date | 2013-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume102 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/AMO/48686 |
|---|---|
| FullText URL | 66_4_317.pdf |
| Author | Pak, Wing| Takayama, Fusako| Hasegawa, Azusa| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Nakamoto, Kazuo| Kawasaki, Hiromu| Mori, Akitane| |
| Abstract | This study aimed to investigate the therapeutic effects of the water extract of leaves of Vitis coignetiae Pulliat (VCPL) on nonalcoholic steatohepatitis (NASH) with advanced fibrosis, as our previous study exhibited its preventive effect on NASH. The NASH animal model [PCT/JP2007/52477] was prepared by loading recurrent and intermittent hypoxemia stress to a rat with fatty liver, which resembled the condition occurring in patients with obstructive sleep apnea (OSA) and fatty liver, who have a high incidence of NASH. Intermittent hypoxemia stress is regarded as a condition similar to warm ischemia followed by re-oxygenation, which induces oxidative stress (OS). The daily 100 or 300mg/kg VCPL administrations were performed for 3 weeks perorally beginning at the time of detection of advanced liver fibrosis. The therapeutic efficacy of VCPL on NASH was demonstrated by the reduction of the leakage of hepato-biliary enzymes and the amelioration of liver fibrosis. The OS elevation in NASH rats was measured based on the derivation of reactive oxygen species from liver mitochondrial energy metabolism and on the decrease in plasma SOD-like activity. The aggravation of inflammatory responses was demonstrated by the neutrophil infiltration (elevated myeloperoxidase activity) and the progression of fibrosis in the livers of NASH rats. In addition, the NASH rats without VCPL treatment also exhibited activation of nuclear factor-κB, a key factor in the link between oxidative stress and inflammation. All of these changes were reduced dose-dependently by the VCPL administration. These findings indicate that VCPL may improve hepatic fibrosis or at least suppress the progression of NASH, by breaking the crosstalk between OS and inflammation. |
| Keywords | non-alcoholic steatohepatitis antioxidative oxidative stress anti-inflammation Vitis coignetiae Pulliat |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-08 |
| Volume | volume66 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 317 |
| End Page | 327 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22918204 |
| Web of Science KeyUT | 000307918900004 |
