result 34 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kuribayashi, Tadahiro| Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Inoue, Hirofumi| Yokoyama, Toshihide| Kuyama, Shoichi| Kato, Yuka| Kudo, Kenichiro| Horita, Naokatsu| Kayatani, Hiroe| Inoue, Masaaki| Sugimoto, Keisuke| Ninomiya, Kiichiro| Maeda, Yoshinobu| Togashi, Yosuke| Hotta, Katsuyuki| |
| Published Date | 2026-02-01 |
| Publication Title | Cancer Research Communications |
| Volume | volume6 |
| Issue | issue2 |
| Publisher | American Association for Cancer Research (AACR) |
| Start Page | 284 |
| End Page | 293 |
| ISSN | 2767-9764 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors |
| File Version | publisher |
| PubMed ID | 41529251 |
| DOI | 10.1158/2767-9764.crc-25-0545 |
| Web of Science KeyUT | 001693865300001 |
| Related Url | isVersionOf https://doi.org/10.1158/2767-9764.crc-25-0545 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuoka, Atsushi| Shien, Kazuhiko| Tomida, Shuta| Ohki, Masayoshi| Hisamatsu, Kazuya| Fujiwara, Ryota| Ishimura, Kosei| Fujii, Ryunosuke| Higashihara, Tomoaki| Hayashi, Naohiro| Okada, Kazuhiro| Yoshichika, Ryo| Mukohara, Fumiaki| Yoshikawa, Mao| Fukumoto, Yuma| Suzawa, Ken| Tomioka, Yasuaki| Tanaka, Shin| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Otani, Yusuke| Tanaka, Atsushi| Inoue, Hirofumi| Togashi, Yosuke| Yamamoto, Hidetaka| Ennishi, Daisuke| Toyooka, Shinichi| |
| Published Date | 2025-12-16 |
| Publication Title | Communications Biology |
| Volume | volume8 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1773 |
| ISSN | 2399-3642 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 41402584 |
| DOI | 10.1038/s42003-025-09162-w |
| Related Url | isVersionOf https://doi.org/10.1038/s42003-025-09162-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Baba, Takahiro| Inoue, Hirofumi| Matsuoka, Hiromi| Kyakuno, Mio| Yoshinaga, Yusuke| Takeguchi, Tetsuya| Fujiwara, Miho| Yamada, Kotaro| Nakamura, Eri| Morita, Ayako| Hara, Naofumi| Ninomiya, Kiichiro| Higo, Hisao| Fujii, Masanori| Ichihara, Eiki| Rai, Kammei| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Togashi, Yosuke| Makimoto, Go| |
| Keywords | lung adenocarcinoma EML4-ALK AmoyDxⓇ Pan Lung Cancer PCR Panel alectinib |
| Published Date | 2025-12-01 |
| Publication Title | Internal Medicine |
| Volume | volume64 |
| Issue | issue23 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 3413 |
| End Page | 3418 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 40399085 |
| DOI | 10.2169/internalmedicine.5397-25 |
| Web of Science KeyUT | 001494126400001 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.5397-25 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakamoto, Yoshihiro| Nakata, Eiji| Hamada, Masanori| Katayama, Yoshimi| Sugihara, Shinsuke| Ozaki, Toshifumi| |
| Keywords | anaplastic lymphoma kinase bone metastases epidermal growth factor receptor-tyrosine kinase lactate dehydrogenase non-small cell lung cancer skeletal related events |
| Published Date | 2025-10-31 |
| Publication Title | Cureus |
| Volume | volume17 |
| Issue | issue10 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | e95808 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Copyright 2025 Sakamoto et al. |
| File Version | publisher |
| PubMed ID | 41181775 |
| DOI | 10.7759/cureus.95808 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.95808 |
| FullText URL | K0007347_abstract_review.pdf K0007347_fulltext.pdf K0007347_summary.pdf |
|---|---|
| Author | NISHI, Tatsuya| |
| Published Date | 2025-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7347号 |
| Granted Date | 2025-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2025 The Author(s). |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokode, Akiyoshi| Fujiwara, Masaki| Nakamura, Yuko| Ohashi, Kadoaki| Sakamoto, Shinji| Takaki, Manabu| |
| Keywords | psycho-oncology lorlatinib lung cancer medication-induced psychosis |
| Published Date | 2025-04-27 |
| Publication Title | Psychiatry and Clinical Neurosciences Reports |
| Volume | volume4 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | e70091 |
| ISSN | 2769-2558 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40291168 |
| DOI | 10.1002/pcn5.70091 |
| Web of Science KeyUT | 001476913400001 |
| Related Url | isVersionOf https://doi.org/10.1002/pcn5.70091 |
| FullText URL | K0006976_abstract_review.pdf K0006976_fulltext.pdf K0006976_summary.pdf |
|---|---|
| Author | ANDO, Chihiro| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6976号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 The Authors. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ando, Chihiro| Ichihara, Eiki| Nishi, Tatsuya| Morita, Ayako| Hara, Naofumi| Takada, Kenji| Nakasuka, Takamasa| Watanabe, Hiromi| Kano, Hirohisa| Nishii, Kazuya| Makimoto, Go| Kondo, Takumi| Ninomiya, Kiichiro| Fujii, Masanori| Kubo, Toshio| Ohashi, Kadoaki| Matsuoka, Ken-Ichi| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | alectinib ALK gilteritinib non-small cell lung cancer TKI |
| Published Date | 2023-09-15 |
| Publication Title | Cancer Science |
| Volume | volume114 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | 4343 |
| End Page | 4354 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37715310 |
| DOI | 10.1111/cas.15958 |
| Web of Science KeyUT | 001067479000001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15958 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Soejima, Yoshiaki| Iwata, Nahoko| Nakayama, Nanako| Hirata, Shinichi| Nakano, Yasuhiro| Yamamoto, Koichiro| Suyama, Atsuhito| Oguni, Kohei| Nada, Takahiro| Fujisawa, Satoshi| Otsuka, Fumio| |
| Keywords | bone morphogenetic protein (BMP) clock gonadotropin orexin pituitary |
| Published Date | 2022-08-29 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue17 |
| Publisher | MDPI |
| Start Page | 9782 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36077179 |
| DOI | 10.3390/ijms23179782 |
| Web of Science KeyUT | 000851102000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms23179782 |
| FullText URL | K0006533_abstract_review.pdf K0006533_fulltext.pdf K0006533_summary.pdf |
|---|---|
| Author | Kano, Hirohisa| |
| Published Date | 2022-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6533号 |
| Granted Date | 2022-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2021 American Association for Cancer Research |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Satouchi, Miyako| Nosaki, Kaname| Takahashi, Toshiaki| Nakagawa, Kazuhiko| Aoe, Keisuke| Kurata, Takayasu| Sekine, Akimasa| Horiike, Atsushi| Fukuhara, Tatsuro| Sugawara, Shunichi| Umemura, Shigeki| Saka, Hideo| Okamoto, Isamu| Yamamoto, Nobuyuki| Sakai, Hiroshi| Kishi, Kazuma| Katakami, Nobuyuki| Horinouchi, Hidehito| Hida, Toyoaki| Okamoto, Hiroaki| Atagi, Shinji| Ohira, Tatsuo| Han, Shi Rong| Noguchi, Kazuo| Ebiana, Victoria| Hotta, Katsuyuki| |
| Keywords | Japan non-small-cell lung carcinoma PD-L1 protein pembrolizumab treatment outcome |
| Published Date | 2021-09-20 |
| Publication Title | Cancer Science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 34543477 |
| DOI | 10.1111/cas.15144 |
| Web of Science KeyUT | 000714623800001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15144 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Hiromi| Ichihara, Eiki| Kayatani, Hiroe| Makimoto, Go| Ninomiya, Kiichiro| Nishii, Kazuya| Higo, Hisao| Ando, Chihiro| Okawa, Sachi| Nakasuka, Takamasa| Kano, Hirohisa| Hara, Naofumi| Hirabae, Atsuko| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Published Date | 2021-01-07 |
| Publication Title | Cancer science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 33410241 |
| DOI | 10.1111/cas.14801 |
| NAID | 120007008532 |
| Web of Science KeyUT | 000630136900001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14801 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Harada, Daijiro| Isozaki, Hideko| Kozuki, Toshiyuki| Yokoyama, Toshihide| Yoshioka, Hiroshige| Bessho, Akihiro| Hosokawa, Shinobu| Takata, Ichiro| Takigawa, Nagio| Hotta, Katsuyuki| Kiura, Katsuyuki| Okayama Lung Cancer Study Group| |
| Keywords | Alectinib anaplastic lymphoma kinase crizotinib drug therapy non-small cell lung carcinoma |
| Published Date | 2021-01-20 |
| Publication Title | Thoracic Cancer |
| Volume | volume12 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 643 |
| End Page | 649 |
| ISSN | 1759-7706 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 33470536 |
| DOI | 10.1111/1759-7714.13825 |
| Web of Science KeyUT | 000608856400001 |
| Related Url | isVersionOf https://doi.org/10.1111/1759-7714.13825 |
| Title Alternative | The 2019 Incentive Awards of the Okayama Medical Association in Cancer Research (2019 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 132_54.pdf |
| Author | Makimoto, Go| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2020-08-03 |
| Volume | volume132 |
| Issue | issue2 |
| Start Page | 54 |
| End Page | 56 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.132.54 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2020 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.132.54 |
| NAID | 130007894955 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Satouchi, Miyako| Nosaki, Kaname| Takahashi, Toshiaki| Nakagawa, Kazuhiko| Aoe, Keisuke| Kurata, Takayasu| Sekine, Akimasa| Horiike, Atsushi| Fukuhara, Tatsuro| Sugawara, Shunichi| Umemura, Shigeki| Saka, Hideo| Okamoto, Isamu| Yamamoto, Nobuyuki| Sakai, Hiroshi| Kishi, Kazuma| Katakami, Nobuyuki| Horinouchi, Hidehito| Hida, Toyoaki| Okamoto, Hiroaki| Atagi, Shinji| Ohira, Tatsuo| Han, Shi Rong| Noguchi, Kazuo| Ebiana, Victoria| Hotta, Katsuyuki| |
| Keywords | Japan non-small-cell lung carcinoma PD-L1 protein pembrolizumab treatment outcome |
| Published Date | 2020-09-14 |
| Publication Title | Cancer Science |
| Volume | volume111 |
| Issue | issue12 |
| Publisher | Wiley |
| Start Page | 4480 |
| End Page | 4489 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32926507 |
| DOI | 10.1111/cas.14647 |
| Web of Science KeyUT | 000577975700001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14647 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| FullText URL | 74_5_371.pdf |
| Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| FullText URL | K0006091_abstract_review.pdf K0006091_summary.pdf K0006091_fulltext.pdf |
|---|---|
| Author | Makimoto, Go| |
| Published Date | 2019-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6091号 |
| Granted Date | 2019-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/57959 |
|---|---|
| FullText URL | 74_1_89.pdf |
| Author | Kada, Akiko| Fukano, Reiji| Mori, Tetsuya| Kamei, Michi| Tanaka, Fumiko| Ueyama, Junichi| Sekimizu, Masahiro| Osumi, Tomoo| Mori, Takeshi| Koga, Yuhki| Ohki, Kentaro| Fujita, Naoto| Mitsui, Tetsuo| Saito, Akiko M.| Hashimoto, Hiroya| Kobayashi, Ryoji| |
| Abstract | No standard treatment for relapsed or refractory anaplastic large-cell lymphoma (ALCL) has been established. This study is a multicenter, open-label trial to examine the effectiveness and safety of transplantation with reduced-intensity conditioning (RIC) for patients under 20 years old with relapsed or refractory ALCL. We defined RIC as the administration of fludarabine (30 mg/m2/day) for five days plus melphalan (70 mg/m2/day) for two days and total body irradiation at 4 Gy, followed by allogeneic hematopoietic stem cell transplantation. |
| Keywords | anaplastic large-cell lymphoma relapsed/refractory fludarabine melphalan total body irradiation |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 94 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099255 |
| Web of Science KeyUT | 000516606200014 |
| NAID | 120006795626 |
| FullText URL | J_Thorac_Oncol_201907017.pdf |
|---|---|
| Author | Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | ALK G1202R Alectinib Amphiregulin MET NSCLC |
| Published Date | 2019-07-30 |
| Publication Title | Journal of Thoracic Oncology |
| Volume | volume14 |
| Issue | issue11 |
| Publisher | Elsevier |
| Start Page | 2009 |
| End Page | 2018 |
| ISSN | 15560864 |
| NCID | AA12058455 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
| File Version | author |
| PubMed ID | 31374369 |
| DOI | 10.1016/j.jtho.2019.07.017 |
| Web of Science KeyUT | 000492678300025 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017 |
| JaLCDOI | 10.18926/AMO/56184 |
|---|---|
| FullText URL | 72_4_431.pdf |
| Author | Sekimizu, Masahiro| Osumi, Tomoo| Fukano, Reiji| Koga, Yuhki| Kada, Akiko| Saito, Akiko M.| Mori, Tetsuya| |
| Abstract | Crizotinib is an inhibitor of multiple tyrosine kinases, including the anaplastic lymphoma kinase (ALK). Responses to crizotinib have also been reported in patients with ALK-positive anaplastic large-cell lymphoma (ALCL) and solid tumors with ALK-mutation, including neuroblastoma. Optimal treatment for patients with recurrent or refractory ALK-positive ALCL and neuroblastoma has not been established. There is a need to develop new drugs for these patients. The objectives of this trial are to evaluate the tolerability and safety of crizotinib in Japanese patients with recurrent/refractory ALK-positive ALCL or neuroblastoma (phase I) and its efficacy in recurrent/refractory ALK-positive ALCL (phase II). |
| Keywords | crizotinib recurrent refractory anaplastic large cell lymphoma neuroblastoma |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-08 |
| Volume | volume72 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 431 |
| End Page | 436 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30140094 |
