result 285 件
| JaLCDOI | 10.18926/AMO/68652 |
|---|---|
| FullText URL | 79_2_129.pdf |
| Author | Tsuji, Akihiro| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Morita, Tetsuro| Takahashi, Kosuke| Morizane, Yuki| |
| Abstract | A 66-year-old woman presented with significant anterior capsule contraction and intraocular lens dislocation in both eyes 4 months after cataract surgery. Postoperative examinations such as fluorescein angiography, Goldmann perimetry, and electroretinography revealed retinitis pigmentosa (RP). Patients with significant anterior capsule contraction after cataract surgery should be closely examined because RP may be a contributing factor. |
| Keywords | retinitis pigmentosa intraocular lens anterior capsule contraction |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68650 |
|---|---|
| FullText URL | 79_2_117.pdf |
| Author | Gautam, Abhishek| Kenawadekar, Rahul| Hattiholi, Virupaxi| Maste, Praful Suresh| |
| Abstract | Neural tube defects are common congenital anomalies, typically presenting early due to visible swelling and/or neurological deficits. Rarely, cystic swellings are neglected until adulthood, with only 14 cases of malignancy developing in an untreated meningomyelocele reported to date. We describe the case details of a 26-year-old Indian woman with this rare complication. Magnetic resonance imaging revealed a low-lying spinal cord with spinal dysraphism, cord herniation, and a cystic lesion. The biopsy confirmed a well-differentiated squamous cell carcinoma. Malignant transformation in an untreated myelomeningocele is rare, with chronic irritation and infection as proposed causes. Early biopsy and treatment are crucial for its management. |
| Keywords | squamous cell carcinoma meningomyelocele occult spinal dysraphism |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 117 |
| End Page | 121 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68644 |
|---|---|
| FullText URL | 79_2_065.pdf |
| Author | Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka| |
| Abstract | Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy. |
| Keywords | anamorelin cancer-associated cachexia body mass index albumin efficacy rate |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 73 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tokumasu, Kazuki| Matsuki, Nobuyoshi| Otsuka, Yuki| Sakamoto, Yoko| Ueda, Keigo| Matsuda, Yui| Sakurada, Yasue| Honda, Hiroyuki| Nakano, Yasuhiro| Hasegawa, Toru| Takase, Ryosuke| Omura, Daisuke| Otsuka, Fumio| |
| Keywords | fatigue assessment scale (FAS) general fatigue hochuekkito kampo medicine long COVID post-COVID-19 condition |
| Published Date | 2025-02-19 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume14 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 1391 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40004921 |
| DOI | 10.3390/jcm14041391 |
| Web of Science KeyUT | 001429605100001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm14041391 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanki, Nobuyoshi| Goto, Sachiko| Katsuda, Toshizo| Gotanda, Rumi| Gotanda, Tatsuhiro| Kuwano, Tadao| |
| Keywords | Backside irradiation computed tomography reflective type radiochromic film ultraviolet radiation |
| Published Date | 2024-10 |
| Publication Title | Journal of Medical Physics |
| Volume | volume49 |
| Issue | issue4 |
| Publisher | Medknow Publications |
| Start Page | 563 |
| End Page | 567 |
| ISSN | 0971-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Journal of Medical Physics |
| File Version | publisher |
| PubMed ID | 39926142 |
| DOI | 10.4103/jmp.jmp_87_24 |
| Web of Science KeyUT | 001422004700010 |
| Related Url | isVersionOf https://doi.org/10.4103/jmp.jmp_87_24 |
| JaLCDOI | 10.18926/AMO/68361 |
|---|---|
| FullText URL | 79_1_047.pdf |
| Author | Kojima, Kazunori| Ujikawa, Takuya| Ono, Toshiro| |
| Abstract | We assessed the immediate effects of a home-based rehabilitation (HBR) program on the balance performance and toe-grip strength of 29 older adults (mean±SD age of 75.1±9.9; 16 males, 13 females) who were participating in HBR services provided by Japan’s nursing care insurance system. Their toe-grip strength and balance performance were measured before and after the HBR program. The subjects’ toe-grip strength was significantly improved after the treatment. The subjects who had had a stroke showed a significant improvement after HBR. Contrarily, no significant difference was observed in the subjects’ functional reach results or their one-leg standing time. These results indicate that the exercise regimen provided in the HBR program led to increased excitability of motor units and immediately enhanced the subjects’ toe-grip strength. |
| Keywords | home-based rehabilitation toe-grip strength balance performance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012159 |
| Web of Science KeyUT | 001440463800006 |
| JaLCDOI | 10.18926/AMO/67877 |
|---|---|
| FullText URL | 78_6_469.pdf |
| Author | Hirata, Yuichi| Nagase, Takayuki| Sasada, Susumu| Ayada, Yoshiyuki| Miyake, Hayato| Sugahara, Chiaki| Yamamoto, Hidetaka| Oda, Yoshinao| Yasuhara, Takao| Tanaka, Shota| |
| Abstract | Tenosynovial giant cell tumor (TGCT) is a fibrous histiocytic tumor originating in the synovial membrane. While cervical TGCT may not be considered a common diagnosis preoperatively because it is relatively rare, it has a high recurrence rate and should be considered. Total resection is preferable, but it can be challenging due to the risk of damaging the vertebral artery. Denosumab has shown effectiveness as a postoperative treatment for osteolytic bone lesion. Denosumab administration coupled with close follow-up might offer an effective postoperative treatment option for unresectable TGCT with bone invasion. |
| Keywords | tenosynovial giant cell tumor bone tumor spine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719321 |
| Web of Science KeyUT | 001397269500003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zinzius, Karen| Marchetti, Giulia Maria| Fischer, Ronja| Milrad, Yuval| Oltmanns, Anne| Kelterborn, Simon| Yacoby, Iftach| Hegemann, Peter| Scholz, Martin| Hippler, Michael| |
| Published Date | 2023-07-20 |
| Publication Title | Plant Physiology |
| Volume | volume193 |
| Issue | issue3 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 2122 |
| End Page | 2140 |
| ISSN | 0032-0889 |
| NCID | AA00775335 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37474113 |
| DOI | 10.1093/plphys/kiad426 |
| Web of Science KeyUT | 001091374700018 |
| Related Url | isVersionOf https://doi.org/10.1093/plphys/kiad426 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Akira| Koda, Masahide| Ogawa, Hiroko| Miyoshi, Tomoko| Maeda, Yoshinobu| Otsuka, Fumio| Ino, Hideo| |
| Keywords | medical interview generative pretrained transformer large language model simulation-based learning OSCE artificial intelligence medical education simulated patients nonrandomized controlled trial |
| Published Date | 2024-09-23 |
| Publication Title | JMIR Medical Education |
| Volume | volume10 |
| Publisher | JMIR Publications |
| Start Page | e58753 |
| ISSN | 2369-3762 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Akira Yamamoto, Masahide Koda, Hiroko Ogawa, Tomoko Miyoshi, Yoshinobu Maeda, Fumio Otsuka, Hideo Ino. |
| File Version | publisher |
| PubMed ID | 39312284 |
| DOI | 10.2196/58753 |
| Web of Science KeyUT | 001334427000001 |
| Related Url | isVersionOf https://doi.org/10.2196/58753 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Masuyama, Hisashi| |
| Published Date | 2024-10-08 |
| Publication Title | BMJ Open |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | BMJ Publishing Group |
| Start Page | e087657 |
| ISSN | 2044-6055 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2024. |
| File Version | publisher |
| PubMed ID | 39384228 |
| DOI | 10.1136/bmjopen-2024-087657 |
| Web of Science KeyUT | 001329970500001 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjopen-2024-087657 |
| FullText URL | fulltext.pdf correction.pdf |
|---|---|
| Author | Miyahara, Hiroyuki| Shigeyasu, Yoshie| Fujii, Chikako| Tanaka, Chie| Mana, Hanzawa| Sugihara, Akiko| Okada, Ayumi| Tsukahara, Hirokazu| |
| Keywords | Anorexia nervosa Dehydration Glomerular filtration rate estimated using creatinine Glomerular filtration rate estimated using cystatin-C Hypokalemia Low free triiodothyronine syndrome |
| Note | The version of record of this article, first published in BioPsychoSocial Medicine, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13030-024-00316-6| |
| Published Date | 2024-09-29 |
| Publication Title | BioPsychoSocial Medicine |
| Volume | volume18 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 19 |
| ISSN | 1751-0759 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39343908 |
| DOI | 10.1186/s13030-024-00316-6 |
| Web of Science KeyUT | 001321447000001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13030-024-00316-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Enomoto, Shota| Oda, Toshiaki| |
| Keywords | computational model Mooney-Rivlin model soft tissue |
| Published Date | 2023-12-04 |
| Publication Title | Biomechanics |
| Volume | volume3 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 583 |
| End Page | 595 |
| ISSN | 2673-7078 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| DOI | 10.3390/biomechanics3040047 |
| Web of Science KeyUT | 001298195700001 |
| Related Url | isVersionOf https://doi.org/10.3390/biomechanics3040047 |
| FullText URL | fulltext20240808-01.pdf |
|---|---|
| Author | Kawase, Tomoka| Debnath, Anusuya| Mizuno, Tamaki| Miyake, Yui| |
| Keywords | Vibrio vulnificus serine protease intermolecular chaperone cell-free translation system |
| Published Date | 2022-11-01 |
| Publication Title | Biological and Pharmaceutical Bulletin |
| Volume | volume45 |
| Issue | issue11 |
| Publisher | Pharmaceutical Society of Japan |
| Start Page | 1596 |
| End Page | 1601 |
| ISSN | 0918-6158 |
| NCID | AA10885497 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Pharmaceutical Society of Japan |
| File Version | publisher |
| PubMed ID | 36328494 |
| DOI | 10.1248/bpb.b22-00106 |
| Web of Science KeyUT | 000886101900001 |
| Related Url | isVersionOf https://doi.org/10.1248/bpb.b22-00106 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokoyama, Sho| Honda, Hiroyuki| Otsuka, Yuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Sakurada, Yasue| Matsuda, Yui| Sunada, Naruhiko| Hasegawa, Toru| Takase, Ryosuke| Omura, Daisuke| Soejima, Yoshiaki| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| Keywords | blood glucose diabetes mellitus long COVID omicron variant post-COVID-19 condition |
| Published Date | 2024-07-13 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume13 |
| Issue | issue14 |
| Publisher | MDPI |
| Start Page | 4099 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39064139 |
| DOI | 10.3390/jcm13144099 |
| Web of Science KeyUT | 001278836700001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm13144099 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawase, Tomoka| Debnath, Anusuya| Okamoto, Keinosuke| |
| Keywords | RTS system in vitro cell-free translation system, PU Proteinase unit, VvsA Vibrio vulnificus serine protease, SD Shine-Dalgarno sequence |
| Published Date | 2024 |
| Publication Title | FEMS Microbiology Letters |
| Volume | volume371 |
| Publisher | Oxford University Press (OUP) |
| Start Page | fnae053 |
| ISSN | 1574-6968 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39020255 |
| DOI | 10.1093/femsle/fnae053 |
| Web of Science KeyUT | 001275776600001 |
| Related Url | isVersionOf https://doi.org/10.1093/femsle/fnae053 |
| JaLCDOI | 10.18926/AMO/67207 |
|---|---|
| FullText URL | 78_3_301.pdf |
| Author | Nakazaki, Kiyoshi| Hirai, Satoshi| Hishikawa, Tomohito| |
| Abstract | We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment. |
| Keywords | vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902220 |
| Web of Science KeyUT | 001267340600001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakanishi, Daiki| Oita, Masataka| Fukunaga, Jun-Ichi| Hirose, Taka-Aki| Yoshitake, Tadamasa| Sasaki, Motoharu| |
| Keywords | 4DCT 3DCT Internal target volume EPID imaging Stereotactic body radiotherapy Lung cancer |
| Note | The version of record of this article, first published in Radiological Physics and Technology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12194-023-00737-y| |
| Published Date | 2023-09-15 |
| Publication Title | Radiological Physics and Technology |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 497 |
| End Page | 505 |
| ISSN | 1865-0333 |
| NCID | AA12236881 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37713060 |
| DOI | 10.1007/s12194-023-00737-y |
| Web of Science KeyUT | 001066741900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s12194-023-00737-y |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66916 |
|---|---|
| FullText URL | 78_2_135.pdf |
| Author | Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Saito, Hayato| Takaki, Haruhiko| Nakagoshi, Ayako| Wada, Maki| Uka, Mayu| Akagi, Noriaki| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao| |
| Abstract | This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with different iodine concentrations (0.2, 0.5, 1, 2, 5, 10, 15, and 20 mg/ml). The CT values of the seven groups (CT1 for 40, 50, 60, and 70 keV; and CT2-4) were measured. Noise and contrast-to-noise ratio (CNR) were assessed for the eight rods at various iodine concentrations. CT2 and CT1 (40 keV) respectively required 20 mg/ml and 5 mg/ml of iodine, indicating that a comparable contrast effect could be obtained with approximately one-fourth of the contrast medium amount. The standard deviation values increased at lower energy levels irrespective of the iodine concentration. The CNR exhibited a decreasing trend with lower iodine concentrations, while it remained relatively stable across all iodine levels (40-70 keV). This study demonstrated that virtual monochromatic 40 keV images offer a similar contrast effect with a reduced contrast medium amount when compared to conventional CT systems at 120 kV. |
| Keywords | photon-counting detector CT energy integrating detector CT computed tomography contrast medium amount reduction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688831 |
| Web of Science KeyUT | 001229151800005 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
