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JaLCDOI 10.18926/AMO/67666
FullText URL 78_5_413.pdf
Author Kashihara, Kenichi| Irisawa, Minoru| Takao, Wataru|
Abstract We investigated patients with migraine or migraine variants who exhibited focal cerebral hypoperfusion on arterial spin-labeled (ASL) magnetic resonance (MR) imaging along with neurological symptoms. Fourteen patients with migraine demonstrated focal cerebral hypoperfusion. Three other patients did not have a history of recurrent headaches but exhibited comparable cerebral hypoperfusion to migraine patients on ASL-MRI in addition to neurological symptoms. Patients with migraine may present with neurological symptoms associated with cortical spreading depression during, after, or even without a headache phase. Additionally, the isolated neurological symptoms may be caused by a pathophysiology identical to that of migraine but without presenting with recurrent headaches.
Keywords arterial spin-labeled magnetic resonance imaging cortical spreading depression migraine complex migraine without headache vertigo
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 413
End Page 421
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467660
FullText URL fulltext.pdf
Author Sa'diyah, Wasiatus| Zhao, Yan-Jie| Chiba, Yuto| Kondo, Hideki| Suzuki, Nobuhiro| Ban, Sayaka| Yaguchi, Takashi| Urayama, Syun-Ichi| Hagiwara, Daisuke|
Keywords Rhizopus microsporus RNA virus diversity new lineage FLDS
Published Date 2024-07-29
Publication Title mSphere
Volume volume9
Issue issue8
Publisher American Society for Microbiology
ISSN 2379-5042
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Sa'diyah et al.
File Version publisher
PubMed ID 39072615
DOI 10.1128/msphere.00345-24
Web of Science KeyUT 001280103000001
Related Url isVersionOf https://doi.org/10.1128/msphere.00345-24
FullText URL fulltext.pdf
Author Tai-Tokuzen, Masako| Ito, Takashi| Tamura, Kazuya| Hirayama, Haruko| Ogawa, Hirohito| Nakamura, Shin| Okubo, Keisuke| Omori, Kazuhiro| Yamamoto, Tadashi| Mominoki, Katsumi| Takashiba, Shogo|
Keywords Cross infection Human and dog Periodontal disease Porphyromonas gingivalis Porphyromonas gulae Detection assay
Published Date 2024-06-15
Publication Title Heliyon
Volume volume10
Issue issue11
Publisher Elsevier
Start Page e31872
ISSN 2405-8440
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors
File Version publisher
DOI 10.1016/j.heliyon.2024.e31872
Web of Science KeyUT 001247098300003
Related Url isVersionOf https://doi.org/10.1016/j.heliyon.2024.e31872
FullText URL fulltext.pdf
Author Sakurada, Takato| Chikada, Yuta| Miyahara, Ryo| Taniguchi, Yosuke|
Keywords 8-oxo-2 '-deoxyguanosine single nucleotide elongation reaction artificial nucleoside triphosphate 2 '-deoxycytidine derivatives
Published Date 2024-05-11
Publication Title Molecules
Volume volume29
Issue issue10
Publisher MDPI
Start Page 2270
ISSN 1420-3049
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 38792131
DOI 10.3390/molecules29102270
Web of Science KeyUT 001231259100001
Related Url isVersionOf https://doi.org/10.3390/molecules29102270
JaLCDOI 10.18926/AMO/66912
FullText URL 78_2_095.pdf
Author Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki|
Abstract The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
Keywords neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 106
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688827
Web of Science KeyUT 001229151800001
JaLCDOI 10.18926/AMO/65745
FullText URL 77_4_365.pdf
Author Moldovan, Elena| Bănescu, Claudia| Cucerea, Manuela| Moldovan, Valeriu| Gozar, Liliana| Pușcașiu, Lucian|
Abstract Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported.
Keywords transposition of the great arteries ductal-dependent coarctation of the aorta GATA4 MLPA Sanger sequencing
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 365
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635136
Web of Science KeyUT 001163659800008
JaLCDOI 10.18926/AMO/65741
FullText URL 77_4_359.pdf
Author Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao|
Abstract Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia.
Keywords pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 364
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635135
Web of Science KeyUT 001163659800011
FullText URL fulltext20230515-02.pdf fig20230515-02.pdf
Author Takao, Daisuke| Kyunai, Yuki M.| Okada, Yasushi| Satoh, Ayano|
Keywords Convolutional neural network Image classification Golgins Golgi Microtubule
Note This is an Accepted Manuscript of a protocol published by Humana New York.| Molecular Biology, vol 2557.| This fulltext file will be available in Dec. 2024.|
Published Date 2022-12-14
Publication Title Golgi
Publisher Humana New York
Start Page 275
End Page 285
Content Type Book
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
File Version author
PubMed ID 36512222
DOI 10.1007/978-1-0716-2639-9_18
Related Url isVersionOf https://doi.org/10.1007/978-1-0716-2639-9_18
JaLCDOI 10.18926/AMO/65148
FullText URL 77_2_185.pdf
Author Sugihara, Akiko| Okada, Ayumi| Horiuchi, Makiko| Yabe, Mayumi| Shigeyasu, Yoshie| Fujii, Chikako| Tanaka, Chie| Yorifuji, Takashi| Tsukahara, Hirokazu|
Abstract Psychosomatic disorders are influenced by psychosocial factors such as interpersonal relationships. Coping behaviors, especially in frustrating situations, reflect a patient’s ability to cope with stress, and it is important to assess these behaviors for the treatment of psychosomatic diseases. This study aimed to clarify the interpersonal relationships and coping behaviors of pediatric patients with psychosomatic diseases during frustrating situations simulated using the Rosenzweig Picture-Frustration study. This retrospective study included 126 patients (41 male, 85 female) with an average age of 12.9 (6-16) years who were consulted at the Department of Pediatric Psychosomatic Medicine at Okayama University Hospital from 2013 to 2018 and underwent the P-F study. Each score was compared with a standardization sample. The mean group conformity rating did not differ significantly between the participants and healthy children. Compared with healthy children, those with psychosomatic diseases were less likely to explain their perspective. The children with psychosomatic disorders responded to frustrating situations in a sensible and age-appropriate manner. However, they were less likely to respond by explaining their perspective to protect themselves.
Keywords psychosomatic disorder picture-frustration study children projective technique group conformity rating
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 185
End Page 192
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094956
Web of Science KeyUT 000982503800008
JaLCDOI 10.18926/AMO/64365
FullText URL 77_1_75.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Abstract Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis.
Keywords autoimmune gastritis esophagogastroduodenoscopy scattered lesions small white protrusions mucosal lesions
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 75
End Page 80
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849149
Web of Science KeyUT 000952973200001
JaLCDOI 10.18926/AMO/62776
FullText URL 75_5_631.pdf
Author Yamamoto, Koichiro| Omura, Daisuke| Yamane, Mai| Son, Reina| Hasegawa, Kou| Honda, Hiroyuki| Obika, Mikako| Minao, Nozomu| Edahiro, Satoru| Yamada, Norihito| Otsuka, Fumio|
Abstract Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.
Keywords anorexia nervosa glucagon hypoglycemic coma insulin-like growth factor-I liver injury
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-10
Volume volume75
Issue issue5
Publisher Okayama University Medical School
Start Page 631
End Page 636
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34703046
Web of Science KeyUT Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa 000711568400001
NAID 120007166676
FullText URL fulltext20210623-2.pdf figure20210623-2.pdf
Author Otsuka, Yuki| Hagiya, Hideharu| Nakano, Yasuhiro| Omura, Daisuke| Hasegawa, Kou| Yamada, Haruto| Iio, Koji| Honda, Tomoyuki| Otsuka, Fumio|
Keywords Human coronavirus Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2
Note © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2021.05.001|
Published Date 2021-7
Publication Title Journal of Infection and Chemotherapy
Volume volume27
Issue issue7
Publisher Elsevier BV
Start Page 1126
End Page 1128
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 33994323
DOI 10.1016/j.jiac.2021.05.001
Web of Science KeyUT 000656910200036
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2021.05.001
FullText URL K0006431_abstract_review.pdf K0006431_fulltext.pdf K0006431_summary.pdf
Author Saiki, Yusuke|
Published Date 2021-03-25
Content Type Thesis or Dissertation
Grant Number 甲第6431号
Granted Date 2021-03-25
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language English
Copyright Holders © 2020 by the authors
JaLCDOI 10.18926/OER/61454
Title Alternative L. Randall Wray 『Modern Monetary Theory; A Primer on Macroeconomics for Sovereign Monetary Systems (2nd Edition)』
FullText URL oer_052_3_075_076.pdf
Author Sakemoto, Ryuta|
Publication Title Okayama Economic Review
Published Date 2021-03-10
Volume volume52
Issue issue3
Start Page 75
End Page 76
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2021 岡山大学経済学会
File Version publisher
NAID 120006980477
FullText URL fulltext.pdf
Author Abe, Fumitaka| Ishida, Yuji| Hisano, Hiroshi| Endo, Masaki| Komari, Toshihiko| Toki, Seiichi| Sato, Kazuhiro|
Published Date 2020-06-13
Publication Title STAR Protocols
Volume volume1
Issue issue2
Publisher Cell Press
Start Page 100053
ISSN 2666-1667
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
DOI 10.1016/j.xpro.2020.100053
Related Url isVersionOf https://doi.org/10.1016/j.xpro.2020.100053
JaLCDOI 10.18926/AMO/57956
FullText URL 74_1_73.pdf
Author Yamane, Masaomi| Mandai, Yasuhiro| Ino, Hideo| Matsukawa, Akihiro| Toyooka, Shinichi|
Abstract In 2016, Gunma University Hospital’s Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a 3-h workshop focusing on the participants’ experiences. We propose that the training course using participant narratives is required and effective to establish surgeons’ self-reflection and professional identity as surgeons.
Keywords professional identity instructor training narrative
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 73
End Page 76
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099252
Web of Science KeyUT 000516606200011
NAID 120006795623
JaLCDOI 10.18926/AMO/57710
FullText URL 73_6_475.pdf
Author Umebayashi, Ryoko| Uchida, Haruhito A.| Wada, Junzo|
Abstract Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture.
Keywords abdominal aortic aneurysms medical treatment anti-platelet drugs
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2019-12
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 477
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871328
Web of Science KeyUT 000503431400001
JaLCDOI 10.18926/AMO/57376
FullText URL 73_5_449.pdf
Author Matsunaga, Kazuyuki| Takemaru, Makoto| Yamashiro, Keisuke| Yoshihara-Hirata, Chiaki| Inohara, Ken| Shimoe, Yutaka| Tanaka, Akio| Kuriyama, Masaru| Takashiba, Shogo|
Abstract We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fractures induced the acute prevertebral abscesses.
Keywords prevertebral abscess deep neck infection periodontal disease peri-implantitis Streptococcus parasanguinis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-10
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 449
End Page 456
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649372
Web of Science KeyUT 000491886600011
FullText URL BriMicroRes_Jou_3_2_190.pdf
Author Mukherjee, Avik Kumar| Karmakar, Sumallya| Raj, Dibyendu| Ganguly, Sandipan|
Keywords Giardia genotyping mixed assemblages local isolates
Published Date 2013-03-22
Publication Title British Microbiology Research Journal
Volume volume3
Issue issue2
Publisher SCIENCEDOMAIN international
Start Page 190
End Page 197
ISSN 22310886
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.9734/BMRJ/2013/2812
Related Url isVersionOf https://doi.org/10.9734/BMRJ/2013/2812
FullText URL Vaccine_32_A20-8.pdf
Author Mullick, Satarupa| Mandal, Paulami| Mukti Kant Nayak| Ghosh, Souvik| De, Papiya| Rajendran, K.| Bhattacharya, Mihir K.| Mitra, Utpala| Ramamurthy, Thandavarayan| Kobayashi, Nobumichi| Chawla-Sarkar, Mamta|
Keywords Diarrhea Rotavirus India Kolkata G9 strains G2 strains
Published Date 2014-08-11
Publication Title Vaccine
Volume volume32
Issue issuesupplment 1
Publisher Elsevier Science
Start Page A20
End Page A28
ISSN 0264410X
NCID AA10491877
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 25091674
DOI 10.1016/j.vaccine.2014.03.018
Web of Science KeyUT 000340977500007
Related Url isVersionOf https://doi.org/10.1016/j.vaccine.2014.03.018