result 357 件
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Dingemans, Anne-Marie C.| Syrigos, Konstantinos| Livi, Lorenzo| Paulus, Astrid| Kim, Sang-We| Chen, Yuanbin| Felip, Enriqueta| Griesinger, Frank| Ohashi, Kadoaki| Zalcman, Gerard| Hughes, Brett G.M.| Sørensen, Jens Benn| Blais, Normand| Ferreira, Carlos G.M.| Lindsay, Colin R.| Dziadziuszko, Rafal| Ward, Patrick J.| Obiozor, Cynthia Chinedu| Wang, Yang| Peters, Solange| |
| Keywords | Brain metastases KRAS G12C-mutated Non-small cell lung cancer NSCLC Randomized controlled trial Sotorasib Survival |
| Published Date | 2025-09 |
| Publication Title | Lung Cancer |
| Volume | volume207 |
| Publisher | Elsevier BV |
| Start Page | 108683 |
| ISSN | 0169-5002 |
| NCID | AA10785743 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40774040 |
| DOI | 10.1016/j.lungcan.2025.108683 |
| Related Url | isVersionOf https://doi.org/10.1016/j.lungcan.2025.108683 |
| FullText URL | fulltext.pdf suppl1.pdf suppl2.pdf suppl3.pdf suppl4.pdf suppl5.pdf suppl6.pdf |
|---|---|
| Author | Hiraoka, Sakiko| Huang, Zhezhou| Qin, Fei| Nathan Arokianathan, Fatima Megala| Davé, Kiran| Shah, Shweta| Kim, Hyunchung| |
| Keywords | Quality of life Presenteeism Absenteeism Ulcerative colitis Japan |
| Published Date | 2025-01-02 |
| Publication Title | Intestinal Research |
| Publisher | Korean Association for the Study of Intestinal Diseases |
| ISSN | 1598-9100 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Korean Association for the Study of Intestinal Diseases. |
| File Version | publisher |
| PubMed ID | 39743354 |
| DOI | 10.5217/ir.2024.00104 |
| Web of Science KeyUT | 001425255600001 |
| Related Url | isVersionOf https://doi.org/10.5217/ir.2024.00104 |
| JaLCDOI | 10.18926/AMO/69159 |
|---|---|
| FullText URL | 79_4_311.pdf |
| Author | Matsubara, Kei| Matsubara, Kei| Hirano, Yutaka| Fujiwara, Toshiya| |
| Abstract | A 55-year-old obese Japanese male with left pneumothorax presented to our hospital. Bilateral pulmonary emphysema was confirmed. Persistent air leakage was observed, and a thoracoscopic bullectomy was performed. Although the thoracoscopic bullectomy was completed uneventfully, pre-extubation chest X-ray imaging indicated hyper-lucency occupying the right upper part of the thoracic cavity, suggesting right-sided pneumothorax. CT imaging indicated a right-upper-lobe expanded bulla. Extubation was performed, and the hyperinflated bulla gradually deflated. Careful management of bulla expansion and respiratory status may be necessary for patients with obesity and large bullae, especially in one-lung ventilation cases. |
| Keywords | giant bulla pneumothorax obesity positive pressure ventilation one lung ventilation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 311 |
| End Page | 315 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69157 |
|---|---|
| FullText URL | 79_4_299.pdf |
| Author | Feng, Ruibin| Zhu, Bikang| Wei, Danyun| Zhu, Dingjiao| Chen, Cairu| |
| Abstract | Pulmonary cement embolism (PCE) is a rare but severe complication following percutaneous vertebroplasty (PVP). Calcium phosphate cement (CPC) has emerged as an alternative to traditional materials for vertebral augmentation. There appear to be no established guidelines for managing symptomatic PCE, and there is scarce literature on CPC embolisms. This is a first report of a case of pulmonary CPC embolism following PVP. The patient, a 63-year-old Chinese female, was administered anticoagulant treatment and achieved a satisfactory outcome. Her case highlights the severe potential morbidity associated with CPC leakage and emphasizes the efficacy of anticoagulant treatment for managing pulmonary CPC embolisms. |
| Keywords | percutaneous vertebroplasty thoracic vertebrae fracture calcium phosphate cement pulmonary embolism |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 303 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69154 |
|---|---|
| FullText URL | 79_4_283.pdf |
| Author | Imamura, Yuta| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Kindo, Hiroya| Morita, Tetsuro| Murai, Aya| Ando, Mizuo| Morizane, Yuki| |
| Abstract | A 76-year-old man presented with right eyelid swelling and deteriorated vision. Examination revealed anterior uveitis with hypopyon and a visual acuity of 20/2,000 in the right eye, with no abnormalities in the left. Computed tomography revealed enlargement of the right maxillary sinus and internal fluid accumulation, suggesting a postoperative maxillary cyst (POMC). Nasal endoscopic surgery drained the pus by opening the lower wall of the maxillary cyst. Following the procedure, intraocular inflammation resolved, and visual acuity in the right eye improved to 24/20. This is the first reported case of uveitis secondary to POMC. |
| Keywords | anterior uveitis hypopyon maxillary sinus postoperative maxillary cyst |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 283 |
| End Page | 286 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69153 |
|---|---|
| FullText URL | 79_4_279.pdf |
| Author | Yoshikawa, Mao| Tao, Hiroyuki| |
| Abstract | An 80-year-old male underwent an extended cholecystectomy for node-positive gallbladder adenocarcinoma. Two weeks later, hemoptysis revealed a left hilar tumor obstructing the bronchus, which was diagnosed as adenocarcinoma. Three months post-cholecystectomy, a left upper pulmonary lobectomy was performed. Histological similarity and positive thyroid transcription factor-1 (TTF-1) immunostaining in both tumors confirmed lung adenocarcinoma with gallbladder metastasis. Despite the generally poor prognosis for gallbladder metastasis from lung cancer, the patient achieved 3 years of survival. Patients with isolated synchronous gallbladder metastasis from lung cancer may benefit from oligometastasectomy. |
| Keywords | gallbladder metastasis lung cancer oligometastatic disease |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69148 |
|---|---|
| FullText URL | 79_4_231.pdf |
| Author | Kardan, M Enes | Erdem, Ilknur| Yildiz, Emre| Kiraz, Nuri| Çelikkol, Aliye| |
| Abstract | Bloodstream infections (BSIs) are an important cause of morbidity and mortality in geriatric patients. We retrospectively analyzed the cases of geriatric patients who developed BSIs due to gram-negative bacteria in order to evaluate the epidemiology, antimicrobial resistance, and the factors affecting mortality. The cases of 110 patients aged ≥ 65 years admitted to our hospital between January 1, 2017, and December 31, 2022 were assessed; 70 (63.6%) of the BSIs were healthcare-associated BSIs. The urinary system was the most common detectable source of infection at 43.6%. The most frequently isolated bacteria were Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, in that order. Carbapenem resistance was detected in 17 patients (15.5%), and extended-spectrum beta-lactamase (ESBL) production from Enterobacterales family members was detected in 37 (51.4%) patients. Multivariate analysis revealed that (i) the probability of mortality in the patients with total bilirubin was increased by approx. sixfold and (ii) the likelihood of mortality for those with a Pitt bacteremia score (PBS) ≥ 4 points was approx. 17 times higher. PBS and simplified qPitt scores can help predict mortality and manage geriatric patients. There is a significant increase in mortality among patients with procalcitonin (PCT) levels at ≥ 2 nm/ml. |
| Keywords | geriatrics gram-negative bacteria epidemiology antimicrobial resistance mortality |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 231 |
| End Page | 242 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69147 |
|---|---|
| FullText URL | 79_4_221.pdf |
| Author | Yumoto, Tetsuya| Naito, Hiromichi| Hongo, Takashi| Obara, Takafumi| Kosaki, Yoshinori| Ageta, Kohei| Nojima, Tsuyoshi| Tsukahara, Kohei| Nakao, Atsunori| |
| Abstract | Extracorporeal cardiopulmonary resuscitation (ECPR) has evolved into a life-saving therapy for select cardiac arrest patients, yet a growing body of evidence suggests it also holds promise as a bridge to organ donation in non-survivors. This review explores the clinical outcomes, ethical complexities, and evolving policies surrounding organ donation after ECPR. We summarize recent international and Japanese data demonstrating favorable graft function from ECPR donors, with the exception of lung transplantation. The ethical challenges — particularly those involving brain death determination on extracorporeal membrane oxygenation and adherence to the dead donor rule — are discussed in the context of Japan’s recent regulatory reforms. Additionally, we highlight the importance of structured end-of-life communication through multidisciplinary team meetings in facilitating ethically sound transitions from rescue efforts to donation pathways. Moving forward, improvements in donor management, standardized legal frameworks, and public and professional education are essential to optimizing the life-saving and life-giving potential of ECPR. |
| Keywords | brain death end-of-life care ethical dilemmas extracorporeal cardiopulmonary resuscitation |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 221 |
| End Page | 229 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf suppl.xlsx |
|---|---|
| Author | Hughes, Holly R.| Ballinger, Matthew J.| Bao, Yiming| Bejerman, Nicolas| Blasdell, Kim R.| Briese, Thomas| Brignone, Julia| Carrera, Jean Paul| De Coninck, Lander| de Souza, William Marciel| Debat, Humberto| Dietzgen, Ralf G.| Dürrwald, Ralf| Erdin, Mert| Fooks, Anthony R.| Forbes, Kristian M.| Freitas-Astúa, Juliana| Garcia, Jorge B.| Geoghegan, Jemma L.| Grimwood, Rebecca M.| Horie, Masayuki| Hyndman, Timothy H.| Johne, Reimar| Klena, John D.| Kondo, Hideki| Koonin, Eugene V.| Kostygov, Alexei Y.| Krupovic, Mart| Kuhn, Jens H.| Letko, Michael| Li, Jun-Min| Liu, Yiyun| Martin, Maria Laura| Mull, Nathaniel| Nazar, Yael| Nowotny, Norbert| Nunes, Márcio Roberto Teixeira| Økland, Arnfinn Lodden| Rubbenstroth, Dennis| Russell, Brandy J.| Schott, Eric| Seifert, Stephanie| Sen, Carina| Shedroff, Elizabeth| Sironen, Tarja| Smura, Teemu| Tavares, Camila Prestes Dos Santos| Tesh, Robert B.| Tilston, Natasha L.| Tordo, Noël| Vasilakis, Nikos| Walker, Peter J.| Wang, Fei| Whitfield, Anna E.| Whitmer, Shannon L.M.| Wolf, Yuri I.| Xia, Han| Ye, Gong-Yin| Ye, Zhuangxin| Yurchenko, Vyacheslav| Zhao, Mingli| |
| Published Date | 2025-07-25 |
| Publication Title | Journal of General Virology |
| Volume | volume106 |
| Issue | issue7 |
| Publisher | Microbiology Society |
| Start Page | 002112 |
| ISSN | 0022-1317 |
| NCID | AA00698722 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Microbiology Society |
| File Version | publisher |
| PubMed ID | 40711815 |
| DOI | 10.1099/jgv.0.002112 |
| Related Url | isVersionOf https://doi.org/10.1099/jgv.0.002112 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Lee, Young-Hyeon| Yeo, Min-Ho| Chang, Kyung-Soo| Yoon, Weon-Jong| Kim, Hye-Sook| Kim, Jongwan| Kim, Hye-Ran| |
| Keywords | metabolic dysfunction-associated steatohepatitis Distylium racemosum ethyl acetate fraction extract |
| Published Date | 2025-06-27 |
| Publication Title | Applied Sciences |
| Volume | volume15 |
| Issue | issue13 |
| Publisher | MDPI AG |
| Start Page | 7238 |
| ISSN | 2076-3417 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/app15137238 |
| Related Url | isVersionOf https://doi.org/10.3390/app15137238 |
| JaLCDOI | 10.18926/AMO/68730 |
|---|---|
| FullText URL | 79_3_213.pdf |
| Author | Watanabe, Makoto| Ogawa, Tomoyuki| Kobayashi, Kanao| Katsuya, Narutaka| Ishikawa, Akira| Hamamoto, Takao| Tahara, Hiroaki| Ueda, Tsutomu| Takeno, Sachio| |
| Abstract | Renal cell carcinoma (RCC) can metastasize hematogenously and recur after a long dormancy. Chromophobe RCC metastasized to the cervical lymph nodes 10 years after the primary resection in a woman who underwent nephrectomy for RCC (T1aN0M0 stage I). Metastatic RCC diagnosis was confirmed by aspiration. The lymph node mass was resected, and the tumor cells matched chromophobe RCC metastasis. No adjuvant therapy was administered due to the lack of evidence regarding adjuvant therapy for chromophobe RCC. Long-term surveillance is crucial in RCC because of the possibility of late metastasis. We reviewed the clinical aspects and literature on metastatic cervical RCC. |
| Keywords | renal cell carcinoma cervical lymph node metastasis late recurrence head and neck |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 219 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68729 |
|---|---|
| FullText URL | 79_3_209.pdf |
| Author | Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi| |
| Abstract | A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered. |
| Keywords | methemoglobinemia aniline methylene blue cyanosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 209 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68725 |
|---|---|
| FullText URL | 79_3_177.pdf |
| Author | Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro| |
| Abstract | The position attained in total hip arthroplasty (THA) is ideally in the center of the horizontal plane of the acetabulum. However, central placement is not always possible. We hypothesized that differences in approach result in individual differences in cup positioning; thus, we investigated the cup positions of 217 hips that underwent THA. The acetabulum’s anteroposterior diameter was measured, and the cups placed within 2 mm of the line perpendicular to the center as a central placement (central). Of the 217 hips, 68, 114, and 35 hips were anterior, central, and posterior, respectively. In 21 hips, anteroposterior deviation was noted. Among patients operated using the anterolateral approach, 48, 93, and 30 hips were anterior, central, and posterior, respectively. Among those operated using the posterolateral approach, 16, 20, and 4 hips were anterior, central, and posterior, respectively. The cup position shifted either anteriorly or posteriorly to the acetabulum in approximately half of all hips operated using both approaches and tended to shift anteriorly in the hips operated using the posterolateral approach. During THA surgery, it is important to operate with awareness of the center of the acetabulum. |
| Keywords | total hip arthroplasty cup horizontal position total hip arthroplasty approach navigation system computed tomography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 184 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| FullText URL | 79_3_167.pdf |
| Author | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| Abstract | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| Keywords | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68652 |
|---|---|
| FullText URL | 79_2_129.pdf |
| Author | Tsuji, Akihiro| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Morita, Tetsuro| Takahashi, Kosuke| Morizane, Yuki| |
| Abstract | A 66-year-old woman presented with significant anterior capsule contraction and intraocular lens dislocation in both eyes 4 months after cataract surgery. Postoperative examinations such as fluorescein angiography, Goldmann perimetry, and electroretinography revealed retinitis pigmentosa (RP). Patients with significant anterior capsule contraction after cataract surgery should be closely examined because RP may be a contributing factor. |
| Keywords | retinitis pigmentosa intraocular lens anterior capsule contraction |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302285 |
| Web of Science KeyUT | 001485535700001 |
| JaLCDOI | 10.18926/AMO/68651 |
|---|---|
| FullText URL | 79_2_123.pdf |
| Author | Akatsuka, Riku| Kimura, Shuhei| Matoba, Ryo| Morizane Hosokawa, Mio| Shiode, Yusuke| Morita, Tetsuro| Doi, Shinichiro| Morizane, Yuki| |
| Abstract | A 78-year-old woman presented with sudden vision loss and central scotoma. Visual acuity in the right eye was 20/222, with submacular hemorrhage (SMH) and Henle fiber layer hemorrhage (HFLh) due to retinal arterial macroaneurysm (RAM) rupture. She underwent SMH displacement, including cataract surgery, vitrectomy, intravitreal injection of tissue-plasminogen activator, and air tamponade. Three months postoperatively the SMH and HFLh had disappeared and visual acuity had improved to 20/200. Six months postoperatively, a macular hole had developed. We performed an inverted internal limiting membrane flap and gas tamponade. Ten months later, the hole had closed and visual acuity had improved to 20/100. |
| Keywords | submacular hemorrhage Henle fiber layer hemorrhage retinal arterial macroaneurysm rupture macular hole inverted internal limiting membrane flap technique |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302284 |
| Web of Science KeyUT | 001485544200008 |
| JaLCDOI | 10.18926/AMO/68648 |
|---|---|
| FullText URL | 79_2_101.pdf |
| Author | Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka| |
| Abstract | To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes. |
| Keywords | breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 101 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302281 |
| Web of Science KeyUT | 001485544200005 |
| JaLCDOI | 10.18926/AMO/68645 |
|---|---|
| FullText URL | 79_2_075.pdf |
| Author | Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Hwang, Sung Il| Kitayama, Takahiro| Takahashi, Yuka| Uka, Mayu| Akagi, Noriaki| Sugaya, Akiko| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao| |
| Abstract | Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%. |
| Keywords | computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302278 |
| Web of Science KeyUT | 001485544200002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumori, Hiroaki| Dinh, Thi Quyen| Miyoshi, Shin-ichi| Morita, Masayuki| Kim, Hye-Sook| |
| Keywords | Synthetic antimalarial endoperoxide Transdermal N-89 Artemisinin In vivo Abnormal trophozoite Endoplasmic reticulum-resident calcium-binding protein (ERC) Parasite egress-related gene |
| Published Date | 2025-06 |
| Publication Title | Parasitology International |
| Volume | volume106 |
| Publisher | Elsevier BV |
| Start Page | 103026 |
| ISSN | 1383-5769 |
| NCID | AA11112001 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 39740755 |
| DOI | 10.1016/j.parint.2024.103026 |
| Web of Science KeyUT | 001414482100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.parint.2024.103026 |
