result 83 件
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ando, Kakeru| Watanabe, Minoru| Watanabe, Nobuya| |
| Note | © 2023 Optica Publishing Group. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.| |
| Published Date | 2023-11-06 |
| Publication Title | Optics Express |
| Volume | volume31 |
| Issue | issue23 |
| Publisher | Optica Publishing Group |
| Start Page | 38529 |
| End Page | 38539 |
| ISSN | 1094-4087 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement |
| File Version | publisher |
| PubMed ID | 38017956 |
| DOI | 10.1364/OE.500666 |
| Web of Science KeyUT | 001108090500007 |
| Related Url | isVersionOf https://doi.org/10.1364/OE.500666 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hagiya, Hideharu| Uno, Mika| Higashionna, Tsukasa| Honda, Hiroyuki| Otsuka, Fumio| |
| Keywords | antimicrobial resistance antimicrobial stewardship antibiotics weekdays weekends |
| Published Date | 2023-06-15 |
| Publication Title | Internal Medicine |
| Volume | volume62 |
| Issue | issue12 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 1739 |
| End Page | 1742 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 36288987 |
| DOI | 10.2169/internalmedicine.0707-22 |
| Web of Science KeyUT | 001015018300001 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.0707-22 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kojima, Keiichi| Kawanishi, Shiho| Nishimura, Yosuke| Hasegawa, Masumi| Nakao, Shin| Nagata, Yuya| Yoshizawa, Susumu| Sudo, Yuki| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-34125-8| |
| Published Date | 2023-04-28 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | nature portfolio |
| Start Page | 6974 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37117398 |
| DOI | 10.1038/s41598-023-34125-8 |
| Web of Science KeyUT | 000985908500047 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-34125-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchiyama, Takaki| Goto, Hidenori| Uesugi, Eri| Takai, Akihisa| Zhi, Lei| Miura, Akari| Hamao, Shino| Eguchi, Ritsuko| Ota, Hiromi| Sugimoto, Kunihisa| Fujiwara, Akihiko| Matsui, Fumihiko| Kimura, Koji| Hayashi, Kouichi| Ueno, Teppei| Kobayashi, Kaya| Akimitsu, Jun| Kubozono, Yoshihiro| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-27701-5| |
| Published Date | 2023-01-11 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | nature portfolio |
| Start Page | 537 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36631625 |
| DOI | 10.1038/s41598-023-27701-5 |
| Web of Science KeyUT | 000986510100067 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-27701-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanabe, Yoshinori| Kiritani, Michiru| Deguchi, Tomomi| Hira, Nanami| Tomimoto, Syouta| |
| Keywords | Patient-specific respiratory motion management Stereotactic body radiotherapy Four-dimensional computed tomography Fiducial marker Lung cancer Gating window |
| Published Date | 2023-01 |
| Publication Title | Physics and Imaging in Radiation Oncology |
| Volume | volume25 |
| Publisher | Elsevier |
| Start Page | 100405 |
| ISSN | 2405-6316 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36655212 |
| DOI | 10.1016/j.phro.2022.12.002 |
| Web of Science KeyUT | 000974743600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.phro.2022.12.002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanabe, Yoshinori| Tanaka, Hidekazu| |
| Keywords | Fiducial marker Respiratory gating method Stereotactic body radiotherapy Tumor tracking Lung cancer 4DCT |
| Published Date | 2022-10-12 |
| Publication Title | Physics and Imaging in Radiation Oncology |
| Volume | volume24 |
| Publisher | Elsevier B.V. |
| Start Page | 82 |
| End Page | 87 |
| ISSN | 24056316 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36267878 |
| DOI | 10.1016/j.phro.2022.10.001 |
| Web of Science KeyUT | 000876945200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.phro.2022.10.001 |
| FullText URL | fulltext20221114-1.pdf |
|---|---|
| Author | Isobe, Hiroshi| Shoji, Mitsuo| Suzuki, Takayoshi| Shen, Jian-Ren| Yamaguchi, Kizashi| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.2c02596| This full-text will be available in Sep. 2023.| |
| Published Date | 2022-09-15 |
| Publication Title | The Journal of Physical Chemistry B |
| Volume | volume126 |
| Issue | issue38 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 7212 |
| End Page | 7228 |
| ISSN | 1520-6106 |
| NCID | AA11114073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 American Chemical Society |
| File Version | author |
| PubMed ID | 36107406 |
| DOI | 10.1021/acs.jpcb.2c02596 |
| Web of Science KeyUT | 000863255500001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jpcb.2c02596 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| JaLCDOI | 10.18926/AMO/63896 |
|---|---|
| FullText URL | 76_4_415.pdf |
| Author | Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan| |
| Abstract | Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction. |
| Keywords | 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123156 |
| Web of Science KeyUT | 000882167300007 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| FullText URL | 76_3_255.pdf |
| Author | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| Abstract | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| Keywords | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Saito, Yukihiro| Nakamura, Kazufumi| Yoshida, Masashi| Sugiyama, Hiroki| Akagi, Satoshi| Miyoshi, Toru| Morita, Hiroshi| Ito, Hiroshi| |
| Keywords | Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 Human induced pluripotent stem cell-derived cardiomyocytes Pacing |
| Published Date | 2022-04-01 |
| Publication Title | STEM Cell Research & Therapy |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 141 |
| ISSN | 1757-6512 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35365232 |
| DOI | 10.1186/s13287-022-02818-y |
| Web of Science KeyUT | 000778298400007 |
| Related Url | isVersionOf https://doi.org/10.1186/s13287-022-02818-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Eissler, Christoph| Werner, Rudolf A.| Arias-Loza, Paula| Nose, Naoko| Chen, Xinyu| Pomper, Martin G.| Rowe, Steven P.| Lapa, Constantin| Buck, Andreas K.| Higuchi, Takahiro| |
| Published Date | 2021-12-06 |
| Publication Title | Molecular Imaging |
| Volume | volume2021 |
| Publisher | Hindawi Ltd. |
| Start Page | 4629459 |
| ISSN | 1536-0121 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Christoph Eissler et al. |
| File Version | publisher |
| PubMed ID | 34987313 |
| DOI | 10.1155/2021/4629459 |
| Web of Science KeyUT | 000741997000001 |
| Related Url | isVersionOf https://doi.org/10.1155/2021/4629459 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsujimura, Masaki| Kojima, Keiichi| Kawanishi, Shiho| Sudo, Yuki| Ishikita, Hiroshi| |
| Published Date | 2021-12-21 |
| Publication Title | Elife |
| Volume | volume10 |
| Publisher | eLIFE SCIENCES PUBL LTD |
| Start Page | e72264 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Tsujimura et al. |
| File Version | publisher |
| PubMed ID | 34930528 |
| DOI | 10.7554/eLife.72264 |
| Web of Science KeyUT | 000733603500001 |
| Related Url | isVersionOf https://doi.org/10.7554/eLife.72264 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Ryoichi| Kodera, Yuta| Ali, Md. Arshad| Kusaka, Takuya| Nogami, Yasuyuki| Morelos-Zaragoza, Robert H.| |
| Keywords | entropy field programmable gate array true random number generator period ring oscillator stomatic process state transition XOR gate |
| Published Date | 2021-09-05 |
| Publication Title | Entropy |
| Volume | volume23 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 1168 |
| ISSN | 1099-4300 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34573793 |
| DOI | 10.3390/e23091168 |
| Web of Science KeyUT | 000699789000001 |
| Related Url | isVersionOf https://doi.org/10.3390/e23091168 |
| FullText URL | fulltext20210924-1.pdf |
|---|---|
| Author | Ho, Dung Thi| Pham, Hung Hoang Son| Aota, Wataru| Matsubayashi, Makoto| Tsuji, Naotoshi| Hatabu, Toshimitsu| |
| Keywords | Eimeria tenella Local immune response Macrophage |
| Note | © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.rvsc.2021.07.003. | |
| Published Date | 2021-10 |
| Publication Title | Research in Veterinary Science |
| Volume | volume139 |
| Publisher | Elsevier BV |
| ISSN | 0034-5288 |
| NCID | AA00816614 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 34252703 |
| DOI | 10.1016/j.rvsc.2021.07.003 |
| Web of Science KeyUT | 000692610100009 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rvsc.2021.07.003 |
| JaLCDOI | 10.18926/AMO/62396 |
|---|---|
| FullText URL | 75_4_447.pdf |
| Author | Kono, Reika| Hamasaki, Ichiro| Kishimoto, Fumiko| Ohtuski, Hiroshi| Shibata, Kiyo| Morizane, Yuki| Shiraga, Fumio| |
| Abstract | In high myopia, eye dislocation due to increased globe volume or tight orbital volume causes acquired esotro-pia. GOR (globe/orbit volume ratio), an indicator of the degree of progression of this pathology, was investi-gated the relationships among easily obtained clinical parameters. In this retrospective study, 20 eyes from 10 acquired esotropia patients with high myopia but without abduction limitations were examined. The mean age of the patients was 63.7 ± 8.2 years (mean ± standard deviation). Volumes were measured on the three-dimen-sional fast imaging employing steady-state acquisition magnetic resonance imaging images using the vol-ume-measurement function. Correlations between GOR and the displacement angle of the globe (DA), axial length (AL), and equatorial diameter (ED) were investigated. Mean DA, AL, ED, and GOR values were 107.5 ± 8.5°, 28.86 ± 1.92 mm, 25.00 ± 1.16 mm, and 0.36 ± 0.05, respectively. Only AL was correlated with GOR (p < 0.0001, R2 = 0.6649); DA (p = 0.30, R2 = 0.0633) and ED (p = 0.91, R2 = 0.0008) were not. AL was the only clinically available parameter to indicate globe/orbit volume imbalances in acquired esotropia with high myopia but without abduction limitation. AL may be important for the clinical assessment of the progression of this pathology. |
| Keywords | acquired esotropia high myopia (high myopes) globe volume magnetic resonance imaging limitation of abduction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 447 |
| End Page | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511611 |
| Web of Science KeyUT | 000697944600006 |
| NAID | 120007146039 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Asada, Saori| Nishii, Nobuhiro| Shinya, Takayoshi| Miyoshi, Akihito| Morimoto, Yoshimasa| Miyamoto, Masakazu| Nakagawa, Koji| Nakamura, Kazufumi| Morita, Hiroshi| Ito, Hiroshi| |
| Published Date | 2021-03-04 |
| Publication Title | PLoS One |
| Volume | volume16 |
| Issue | issue3 |
| Publisher | Public Library of Science |
| Start Page | e0245502 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Asada et al. |
| File Version | publisher |
| PubMed ID | 33661956 |
| NAID | 120007019113 |
| DOI | 10.1371/journal.pone.0245502 |
| Web of Science KeyUT | 000626604100103 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0245502 |
| FullText URL | J_Neurochem.pdf |
|---|---|
| Author | Yoshida, Ryusuke| Margolskee, Robert F.| Ninomiya, Yuzo| |
| Keywords | energy homeostasis leptin signaling metabolic sensor obesity sweet receptor cell |
| Note | "This is the peer reviewed version of the following article: Ryusuke Yoshida et.al. Phosphatidylinositol‐3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells. Journal of Neurochemistry (2020), which has been published in final form at https://doi.org/10.1111/jnc.15268. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-12-15 |
| Publication Title | Journal of Neurochemistry |
| Volume | volume158 |
| Publisher | Wiley |
| Start Page | 233 |
| End Page | 245 |
| ISSN | 0022-3042 |
| NCID | AA11628230 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33319361 |
| DOI | 10.1111/jnc.15268 |
| Web of Science KeyUT | 000621963500001 |
| Related Url | isVersionOf https://doi.org/10.1111/jnc.15268 |
| JaLCDOI | 10.18926/AMO/61209 |
|---|---|
| FullText URL | 74_6_495.pdf |
| Author | Calliope, Simba Akintije| Yorifuji, Takashi| Wada, Takayuki| Mukakarake, Marie Goret| Mutesa, Leon| Yamamoto, Taro| |
| Abstract | In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings. |
| Keywords | antenatal care epidemiology low birth weight preterm birth rural |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 495 |
| End Page | 503 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361869 |
| Web of Science KeyUT | 000601203600005 |
| NAID | 120006948958 |
