result 1468 件
| FullText URL | O0004430_abstract_review.pdf O0004430_fulltext.pdf |
|---|---|
| Author | Siti Hajar Noor Binti Shaarani| |
| Published Date | 2014-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4430号 |
| Granted Date | 2014-09-30 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
| JaLCDOI | 10.18926/AMO/52900 |
|---|---|
| FullText URL | 68_5_307.pdf |
| Author | Muro, Shinichiro| Nasu, Junichiro| Harada, Ryo| Matsubara, Minoru| Nakarai, Asuka| Kanzaki, Hiromitsu| Tsutsumi, Kouichiro| Kato, Hironari| Tanaka, Takehiro| Fujiwara, Hiroyasu| Uno, Masatoshi| Okada, Hiroyuki| Yamamoto, Kazuhide| |
| Abstract | A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and serum tumor markers. Fine needle aspiration revealed Grade 3 small-cell type primary pancreatic neuroendocrine carcinoma. Consequently, the diagnosis of malignant insulinoma was made. Transarterial embolization (TAE) for hepatic metastases resulted in the reduction of tumor volume and prompt resolution of hypoglycemic attacks, whereas diazoxide and systemic chemotherapy had been ineffective for controlling blood glucose levels, and octreotide was unavailable due to the allergic effect. This case report highlights the potential usefulness of TAE for malignant insulinomas in the management of hypoglycemia. |
| Keywords | malignant insulinoma hypoglycemia liver metastases transarterial embolization neuroendocrinetumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 311 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338488 |
| Web of Science KeyUT | 000343269300008 |
| JaLCDOI | 10.18926/AMO/52896 |
|---|---|
| FullText URL | 68_5_277.pdf |
| Author | Miyasaka, Dai| Ito, Tomoyuki| Imai, Norio| Suda, Ken| Minato, Izumi| Dohmae, Yoichiro| Endo, Naoto| |
| Abstract | The acetabular coverage of the femoral head has been assessed in two-dimensions as the projected covered area or the covered angle on plain radiographs. We present a novel method of the three-dimensional assessment of femoral head coverage obtained by evaluating the covered volume of the femoral head in both normal and dysplastic hips. We also assessed the covered angles on the vertical slices passing through the center of the femoral head. The mean covered volume of the femoral head was 57.4% in normal hips and 26.6% in dysplastic hips. In dysplastic hips, the L-CE, A-CE, and P-CE angles were 7.7°, 21.8°, and 95.8°, respectively, while the acetabular angle was 27.5°. In normal hips, the CE angles were 34.0°, 56.8°, and 109.4°, respectively, while the acetabular angle was 7.2°. Our study suggests the usefulness of a novel 3D assessment for acetabular coverage of the femoral head. This assessment provided the precise 3D information necessary to diagnose hip dysplasia and assess the deficiency of acetabular coverage in these patients. Moreover, we may detect a cut-off between normal and dysplastic hips in the 3D assessment by assessing a large number of dysplastic hips both morphologically and using the new assessment. |
| Keywords | hip dysplasia three-dimensional imaging femoral head coverage acetabulum patient positioning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 277 |
| End Page | 284 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338484 |
| Web of Science KeyUT | 000343269300004 |
| Author | Kono, Syoichiro| Deguchi, Kentaro| Omote, Yoshio| Yunoki, Taijun| Yamashita, Toru| Kurata, Tomoko| Ikeda, Yoshio| Abe, Koji| |
|---|---|
| Published Date | 2014-01 |
| Publication Title | Journal of Neuroscience Research |
| Volume | volume92 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Omote, Yoshio| Deguchi, Kentaro| Tian, FengFeng| Kawai, Hiromi| Kurata, Tomoko| Yamashita, Toru| Ohta, Yasuyuki| Abe, Koji| |
|---|---|
| Published Date | 2012-06 |
| Publication Title | Stroke |
| Volume | volume43 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao| |
|---|---|
| Published Date | 2013-09 |
| Publication Title | Neuroradiology |
| Volume | volume55 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Endocrine Journal |
| Volume | volume60 |
| Issue | issue12 |
| Content Type | Journal Article |
| FullText URL | K0004896_abstract_review.pdf K0004896_fulltext.pdf |
|---|---|
| Author | Itami, Hisakazu| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4896号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| JaLCDOI | 10.18926/bgeou/52429 |
|---|---|
| Title Alternative | Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders |
| FullText URL | 110_0029_0034.pdf |
| Author | Sanada, Satoshi| Asano, Takashi| Oka, Eiji| Kawahara, Michiko| Sakae, Katsumi| Hiraki, Norio| Ohtahara, Shunsuke| |
| Abstract | Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA)，creatine (Cr) and choline (Ch). Hence，clinical applications of this method for neuropediatric diseases can be expected. However，regarding neuronal migration disorders，there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders，ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr，Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ～ 3 × 3 × 5cm3 was chosen in the area including lesions，and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41，1.95，2.27 and 1.71 in cases with heterotopic gray matter，0.99 in one case with polymicrogyria，an d 1.30 in one case with hemimegalencephaly，contrasted with a contralataral area without lesions: 1.89， 2.89，2.87，2.55，3.26，2.03，respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population，or reduced metabolism in the lesions. |
| Keywords | MR spectroscopy migration disorder heterotopic gray matter polymicrogyria hemimegalencephaly |
| Publication Title | 岡山大学教育学部研究集録 |
| Published Date | 1999-03-15 |
| Volume | volume110 |
| Start Page | 29 |
| End Page | 34 |
| ISSN | 0471-4008 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005425646 |
| JaLCDOI | 10.18926/AMO/52142 |
|---|---|
| FullText URL | 68_1_35.pdf |
| Author | Araki, Motoo| Jeong, Wooju| Park, Sung Yul| Lee, Young Hoon| Nasu, Yasutomo| Kumon, Hiromi| Hong, Sung Joon| Rha, Koon Ho| |
| Abstract | The purpose of this study was to compare the positive surgical margin (PSM) rates of 2 techniques of robot-assisted radical prostatectomy (RARP) for pT2 (localized) prostate cancer. A retrospective analysis was conducted of 361 RARP cases, performed from May 2005 to September 2008 by a single surgeon (KHR) at our institution (Yonsei University College of Medicine). In the conventional technique, the bladder neck was transected first. In the modified ultradissection, the lateral border of the bladder neck was dissected and then the bladder neck was transected while the detrusor muscle of the bladder was well visualized. Perioperative characteristics and outcomes and PSM rates were analyzed retrospectively for pT2 patients (n＝217), focusing on a comparison of those undergoing conventional (n＝113) and modified ultradissection (n＝104) techniques. There was no difference between the conventional and modified ultradissection group in mean age, BMI, PSA, prostate volume, biopsy Gleason score, and DʼAmico prognostic criteria distributions. The mean operative time was shorter (p＜0.001) and the estimated blood loss was less (p＜0.01) in the modified ultradissection group. The PSM rate for the bladder neck was significantly reduced by modified ultradissection, from 6.2% to 0% (p＜0.05). In conclusion, modified ultradissection reduces the PSM rate for the bladder neck. |
| Keywords | robot-assisted radical prostatectomy prostate cancer surgery surgical margin technique |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 35 |
| End Page | 41 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553487 |
| Web of Science KeyUT | 000331592800006 |
| JaLCDOI | 10.18926/AMO/52140 |
|---|---|
| FullText URL | 68_1_23.pdf |
| Author | Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro| |
| Abstract | The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM. |
| Keywords | mesothelioma microRNA microRNA-34b/c p53 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 23 |
| End Page | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553485 |
| Web of Science KeyUT | 000331592800004 |
| Author | Yoshida, Yuichi| Ohmori, Toshimasa| Goto, Tanjuro| Tanaka, Yoshiyuki| Murakami, Kenji| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Naito, H.| Takeda, Y.| Danura, T.| Kass, I. S.| Morita, K.| |
|---|---|
| Published Date | 2013-04-03 |
| Publication Title | Neuroscience |
| Volume | volume235 |
| Content Type | Journal Article |
| Author | Inouye, Narinobu| Maeda, Takanori| Mitsuhata, Koji| |
|---|---|
| Published Date | 1989-03 |
| Publication Title | 農学研究 |
| Volume | volume61 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
| Author | Takamiya, M.| Miyamoto, Y.| Yamashita, T.| Deguchi, K.| Ohta, Y.| Abe, K.| |
|---|---|
| Published Date | 2012-09-27 |
| Publication Title | Neuroscience |
| Volume | volume221 |
| Content Type | Journal Article |
| Author | Ishikura, Satoshi| Kajihara, Shinji| Fukushima, Keigo| Goto, Tanjuro| |
|---|---|
| Published Date | 2013-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume102 |
| Content Type | Departmental Bulletin Paper |
| Author | Yamaguchi, Norihito| Goto, Tanjuro| Kobiki, Kayoko| Otani, Shoko| Yoshida, Yuichi| |
|---|---|
| Published Date | 2013-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume102 |
| Content Type | Departmental Bulletin Paper |
| Author | Yoshida, Yuichi| Shingai, Aya| Ooyama, Mitsuo| Murakami, Kenji| Goto, Tanjuro| |
|---|---|
| Published Date | 2013-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume102 |
| Content Type | Departmental Bulletin Paper |
| Author | Inazumi, Daichi| Yoshida, Yuichi| Goto, Tanjuro| Murakami, Kenji| |
|---|---|
| Published Date | 2013-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume102 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/AMO/49039 |
|---|---|
| FullText URL | 66_6_435.pdf |
| Author | Fujinaka, Waso| Shimizu, Juichiro| Iribe, Gentaro| Imaoka, Takeshi| Oshima, Yu| Kiyooka, Takahiko| Morita, Kiyoshi| Mohria, Satoshi| |
| Abstract | Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-Vo2 (myocardial oxygen consumption per beat) relationship. We obtained 1) the Vo2-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the Vo2-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the Vo2-PVA relationship under increased intracoronary concentrations of either propofol or CaCl2 at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear Vo2-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent Vo2-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca2＋. In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca2＋ blockers or ß-antagonists—i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA. |
| Keywords | anesthesia heart contractility myocardial oxygen consumption |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-12 |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 435 |
| End Page | 442 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254577 |
| Web of Science KeyUT | 000312966100002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/49732 |
