result 944 件
| Author | Ranaweera, Lalindra Vishwajith| |
|---|---|
| Published Date | 2011-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| JaLCDOI | 10.18926/AMO/47009 |
|---|---|
| FullText URL | 65_5_279.pdf |
| Author | Miyoshi, Ko| Kasahara, Kyosuke| Miyazaki, Ikuko| Asanuma, Masato| |
| Abstract | Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors. |
| Keywords | primary cilium length lithium cyclic AMP soluble tubulin intraflagellar transport |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 285 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037264 |
| Web of Science KeyUT | 000296116400001 |
| Author | Kitamatsu, Mizuki| Futami, Midori| Sisido, Masahiko| |
|---|---|
| Published Date | 2010 |
| Publication Title | Chemical Communications |
| Volume | volume46 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Nanba, Tokuro| Miura, Yoshinari| Sakida, Shinichi| |
|---|---|
| Published Date | 2005-01 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume113 |
| Issue | issue1313 |
| Content Type | Journal Article |
| Author | Nanba, Tokuro| Mikami, Shuhei| Imaoka, Takuya| Sakida, Shinichi| Miura, Yoshinari| |
|---|---|
| Published Date | 2008-02 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume116 |
| Issue | issue1350 |
| Content Type | Journal Article |
| Author | Nanba, Tokuro| Kuroda, Yutaro| Sakida, Shinichi| Benino, Yasuhiko| |
|---|---|
| Published Date | 2009-11 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume117 |
| Issue | issue1371 |
| Content Type | Journal Article |
| Author | Saiki, Keiji| Sakida, Shinichi| Benino, Yasuhiko| Nanba, Tokuro| |
|---|---|
| Published Date | 2010-07 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume118 |
| Issue | issue1379 |
| Content Type | Journal Article |
| Author | Manchur, Mohammed Abul| Kikumoto, Mei| Kanao, Tadayoshi| Takada, Jun| Kamimura, Kazuo| |
|---|---|
| Published Date | 2011-05 |
| Publication Title | Extemophiles |
| Volume | volume15 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kuroda, Shinji| Fujiwara, Toshiya| Shirakawa, Yasuhiro| Yamasaki, Yasumoto| Yano, Syuya| Uno, Futoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Watanabe, Yuichi| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Morikawa, Hisasi| |
|---|---|
| Published Date | 1929-04-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume41 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Morikawa, Hisasi| |
|---|---|
| Published Date | 1929-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume41 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hayasi, Kanae| Okuyama, Misao| |
|---|---|
| Published Date | 1929-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume41 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Murakami, Kensuke| |
|---|---|
| Published Date | 1930-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume42 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Takahashi, Shinji| Shimizu, Akira| Kawashima, Takaharu| |
|---|---|
| Published Date | 2011-05 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume27 |
| Content Type | Others |
| Author | Kosaka, Hisasi| |
|---|---|
| Published Date | 1935-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kawamura, Keniti| |
|---|---|
| Published Date | 1937-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Hudino, Hironori| |
|---|---|
| Published Date | 1938-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume50 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Hasimoto, Kiyosi| |
|---|---|
| Published Date | 1939-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume51 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Yamada, Hiroshi| Padilla-Parra, Sergi| Park, Sun Joo| Itoh, Toshiki| Chaineau, Mathilde| Monaldi, Ilaria| Cremona, Ottavio| Benfenati, Fabio| Camilli, Pietro De| Coppey-Moisan, Maïté| Tramier, Marc| Galli, Thierry| Takei, Kohji| |
|---|---|
| Published Date | 2011-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Tamao, Nobutada| |
|---|---|
| Published Date | 1942-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume54 |
| Issue | issue10 |
| Content Type | Journal Article |
