result 3913 件
| JaLCDOI | 10.18926/AMO/43829 |
|---|---|
| FullText URL | 65_1_41.pdf |
| Author | Tokumori, Kimihiko| Wang, Da-Hong| Takigawa, Tomoko| Takaki, Jiro| Ogino, Keiki| |
| Abstract | This study aimed to determine whether there was any association between the regional climate and the proportion of people with joint pain. Regional climate data between 1971 and 2000 were obtained from the Japan Meteorological Agency. The variables used in the cluster analysis included sunlight hours, amount of precipitation, number of days with precipitation, and temperature. The regional proportion of people with joint pain was obtained from the National Survey for Health in 2001. After performing a cluster analysis, one-way ANOVA and Welch's test were used to determine whether the climate characteristics of the clusters were significantly different. Within each cluster, stepwise multiple linear regression analyses were performed. We found that sunlight hours showed a direct, negative association with the proportion of people with joint pain (adjusted R2＝0.532, p＝0.016) in cluster 1, which was characterized as the region with the fewest total hours of sunlight, less precipitation, a modest number of rainy days, and low temperature. In the other clusters, the regional female population rate (cluster 2) and the senior population rate (cluster 3, 4) were the primary predictors. We concluded that the degree of exposure to sunlight may play a crucial role in prevention of joint pain. This finding should encourage people to set aside some time for staying outdoors in their daily lives. |
| Keywords | climate joint pain sunlight hours cluster analysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 41 |
| End Page | 48 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339795 |
| Web of Science KeyUT | 000287620500006 |
| JaLCDOI | 10.18926/AMO/43828 |
|---|---|
| FullText URL | 65_1_33.pdf |
| Author | Yanagawa, Youichi| Nishi, Kouichirou| Imamura, Tomonori| Sakamoto, Toshihisa| |
| Abstract | Computed tomography (CT) is superior for the detection of substances with low radiolucency in comparison with abdominal roentgenograms. In the present study, medical chart review was retrospectively performed for patients who were admitted and underwent plain CT including the stomach on arrival to investigate whether CT is useful for diagnosing overdose (OD). The subjects were divided into patients with OD who did not undergo gastric lavage (OD group) and those without OD (Control group). The presence of a radiopaque area (Hounsfield number over 100 on a range of interest of 3mm2) in the stomach on CT was defined as a positive finding. The average Glasgow Coma Scale in the OD group (n＝11) was significantly lower than that in the Control group (n＝137). Positive findings on CT were found more frequently in the OD group than in the Control group (100 vs. 19.7%, p＜0.0001). Based on the finding of a high-density deposition in the bottom of the stomach, the CT predicted OD with 98.5% specificity. Accordingly, CT findings of a high-density deposition in the stomach of a patient with a diminished consciousness may suggest the presence of a recent overdose. |
| Keywords | overdose diagnosis CT |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 33 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339794 |
| Web of Science KeyUT | 000287620500005 |
| JaLCDOI | 10.18926/AMO/43827 |
|---|---|
| FullText URL | 65_1_27.pdf |
| Author | Togami, Taro| Yamamoto, Yuka| Satoh, Katashi| Kameyama, Reiko| Murota, Makiko| Kimura, Naruhide| Nishiyama, Yoshihiro| |
| Abstract | We performed a retrospective study examining the prevalence and subtypes of pulmonary emphysema (PE) identified by computed tomography (CT) in females. We reviewed the records of 1,687 female subjects who had undergone CT. They were divided into the following 2 age groups:group A (＜50 years) and group B (>_50 years). PE was diagnosed by the presence of low-attenuation areas using visual assessment (grades 0-3) on CT images. Two subtypes of PE were observed:centrilobular emphysema (CLE) and paraseptal emphysema (PSE). PE was divided into the following 3 categories:I (CLE or CLE-predominant);II (CLE and PSE of equal extent);and III (PSE or PSE-predominant). PE was found in 64 of 274 smokers (23.3%) and 54 of 1,413 non-smokers (3.8%). In smoking subjects, when grades 1 and 2 were grouped together as mild PE, the mean age for CT grade 3 (severe PE) was significantly higher than that for mild PE. In group A, category III predominated, whereas category I was more prevalent in group B, in both smoking and non-smoking subjects. A high incidence of PE was found in smoking subjects as compared with non-smoking subjects. PSE predominated in younger subjects, whereas CLE predominated in older subjects. |
| Keywords | cigarette smoking CT pulmonary emphysema females |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 27 |
| End Page | 32 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339793 |
| Web of Science KeyUT | 000287620500004 |
| JaLCDOI | 10.18926/AMO/43826 |
|---|---|
| FullText URL | 65_1_21.pdf |
| Author | Tamura, Hiroko| Suzue, Takeshi| Jitsunari, Fumihiko| Hirao, Tomohiro| |
| Abstract | The aim of this study was to evaluate the carotid arterial intima-media thickness (IMT) and its relation to clinical parameters in Japanese children. Fifty-two healthy children (39 boys and 13 girls), aged 6-14 years, were enrolled in this cross-sectional investigation study. IMT of the common carotid artery was determined using ultrasonography. We also investigated anthropometric parameters, blood pressure (BP), lifestyles and blood examinations. The mean value of IMT was 0.4±0.1mm, which was lower than the normal value (1.0mm) in adults. IMT was positively correlated with age (r＝0.340) and height (r＝0.346) in boys, while it was positively correlated with body mass index (BMI) (r＝0.584) and diastolic BP (DBP) (r＝0.563) in girls. In addition, IMT was associated with sleeping hours and hours of watching television (TV) by using stepwise regression analysis. In conclusion, IMT increased with aging, and it was linked to some clinical parameters of atherosclerosis and lifestyles in children. Therefore, this reference data will be helpful for future assessment of age-related change in Japanese children in clinical practice, and IMT might be a good predictor of atherosclerosis in Japanese children. |
| Keywords | intima-media thickness (IMT) lifestyle Japanese children proportional hazards models atherosclerosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 21 |
| End Page | 25 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339792 |
| Web of Science KeyUT | 000287620500003 |
| JaLCDOI | 10.18926/AMO/43825 |
|---|---|
| FullText URL | 65_1_11.pdf |
| Author | Kuwaki, Kenji| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Nakamura, Shinichiro| Ito, Yoichi M.| Iwadou, Shouta| Hagihara, Hiroaki| Yasunaka, Tetsuya| Toshimori, Junichi| Miyatake, Hirokazu| Miyoshi, Kenji| Onishi, Hideki| Miyake, Yasuhiro| Shoji, Bon| Takaki, Akinobu| Shiraha, Hidenori| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
| Abstract | The purpose of this study was to build a prognostic model of hepatocellular carcinoma (HCC) using time-dependent covariates to re-evaluate the prognosis at any stage of the disease. The subjects were consecutive HCC patients who were treated at our institute between 1995 and 2007. We constructed time-fixed and time-dependent prognostic models with a training group (n＝336) and compared the prognostic abilities between conventional Cancer of the Liver Italian Program (CLIP) scores, Japan Integrated Staging (JIS) scores, an Okuda classification, and our prognostic models in the testing group (n＝227) with the c-index. The time-dependent prognostic model consisted of main tumor size, tumor number, portal vein invasion, distant metastasis, alpha-fetoprotein, des-gamma-carboxy prothrombin (DCP), bilirubin, and albumin and the weighted scores were set for each factor depending on the hazard ratio for the prognosis. The prognostic index was determined by summing the scores. The c-index values for the CLIP scores, JIS scores, Okuda classification, and our time-dependent model were 0.741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC. |
| Keywords | hepatocellular carcinoma humans prognosis proportional hazards models time factors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 11 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339791 |
| Web of Science KeyUT | 000287620500002 |
| JaLCDOI | 10.18926/AMO/43824 |
|---|---|
| FullText URL | 65_1_1.pdf |
| Author | Han, Xiao-Jian| Tomizawa, Kazuhito| Fujimura, Atsushi| Ohmori, Iori| Nishiki, Tei-ichi| Matsushita, Masayuki| Matsui, Hideki| |
| Abstract | Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases. |
| Keywords | mitochondria phosphorylation ubiquitination SUMOylation neurodegeneration |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339790 |
| Web of Science KeyUT | 000287620500001 |
| JaLCDOI | 10.18926/AMO/41327 |
|---|---|
| FullText URL | 64_6_407.pdf |
| Author | Ogata, Sho| Horio, Takuya| Sugiura, Yoshiaki| Shimazaki, Hideyuki| Saito, Hiroki| Aiko, Satoshi| Nakanishi, Kuniaki| Kawai, Toshiaki| |
| Abstract | Sarcoidosis is a systemic granulomatous inflammation of unknown etiology, and seems to involve the liver parenchyma in most cases. However, sarcoidosis-associated hepatocellular carcinoma is rare. We report here a case in which a hepatocellular carcinoma occurred within the liver, which was probably involved as a result of systemic sarcoidosis. A 57-year-old Japanese man had been followed up for 2 years because of diabetic nephropathy and sarcoidosis. On admission for pneumonia, imaging studies revealed an unexpected hepatic tumor. Histology revealed a hepatocellular carcinoma accompanied by T-lymphocytic infiltration and marked granulomatous inflammation, which was surrounding some tumor nodules. The background liver parenchyma exhibited a moderate degree of fibrosis with granulomatous inflammation. The patient had no other apparent liver disease such as viral hepatitis, steatohepatitis, or primary biliary cirrhosis. Therefore, in the present case, sarcoidosis may be considered the probable background etiology for hepatocarcinogenesis. |
| Keywords | granuloma hepatocellular carcinoma lymphocytic infiltration sarcoidosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 410 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173811 |
| Web of Science KeyUT | 000285664200008 |
| JaLCDOI | 10.18926/AMO/41326 |
|---|---|
| FullText URL | 64_6_399.pdf |
| Author | Chang, Chin-Hsien| Chen, Kuo-Ti| Lee, Tsong-Hai| Wang, Chao-Hung| Kuo, Yi-Wen| Chiu, Ya-Huang| Hsieh, Ching-Liang| Wu, Chang-Jer| Chang, Yen-Lin| |
| Abstract | Vascular endothelial damage has been found to be associated with thrombus formation, which is considered to be a risk factor for cardiovascular disease. A diet of natto leads to a low prevalence of cardiovascular disease. The aim of the present study was to investigate the effects of natto extract on vascular endothelia damage with exposure to laser irradiation. Endothelial damage both in vitro and in vivo was induced by irradiation of rose bengal using a DPSS green laser. Cell viability was determined by MTS assay, and the intimal thickening was verified by a histological approach. The antioxidant content of natto extract was determined for the free radical scavenging activity. Endothelial cells were injured in the presence of rose bengal irradiated in a dose-dependent manner. Natto extract exhibits high levels of antioxidant activity compared with purified natto kinase. Apoptosis of laser-injured endothelial cells was significantly reduced in the presence of natto extract. Both the natto extract and natto kinase suppressed intimal thickening in rats with endothelial injury. The present findings suggest that natto extract suppresses vessel thickening as a synergic effect attributed to its antioxidant and anti-apoptosis properties. |
| Keywords | laser irradiation natto extract thrombolysis thrombosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 399 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173810 |
| Web of Science KeyUT | 000285664200007 |
| JaLCDOI | 10.18926/AMO/41325 |
|---|---|
| FullText URL | 64_6_391.pdf |
| Author | Suezawa, Takanori| Ishino, Kozo| Honjo, Osami| Osaki, Satoru| Kotani, Yasuhiro| Sano, Shunji| |
| Abstract | We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ventricle during aortic cross-clamping. This study was performed to determine the appropriate root pressure to maintain the heartbeat without causing deterioration of ventricular function. Study 1. Under partial CPB, the ascending aorta was cross-clamped in 6 pigs (group 1). Experimental data at various systolic aortic root pressures was analysed to determine the appropriate root pressure. Study 2. In group 2 (control, n＝6), the aorta was not clamped, while in group 3 (n＝6), the aorta was cross-clamped for 60 min and the systolic aortic root pressure was maintained at the pressure determined in study 1. Study 1. The diastolic coronary flow was stabilized at values comparable to that before initiation of CPB (6.6±1.4ml/beat) when the systolic aortic root pressure was above 80mmHg. Intracardiac pressure and the myocardial oxygen consumption (MvO2) seemed to be acceptable when the systolic aortic root pressure was below 100mmHg. Therefore, 90mmHg was selected for study 2. Study 2. Perioperative cardiac function did not differ between the groups. We concluded that 90mmHg was the systolic aortic root pressure appropriate for this method. |
| Keywords | aortic cross-clamp coronary flow root pressure cardiopulmonary bypass arch repair |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 397 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173809 |
| Web of Science KeyUT | 000285664200006 |
| JaLCDOI | 10.18926/AMO/41324 |
|---|---|
| FullText URL | 64_6_385.pdf |
| Author | Miyatake, Nobuyuki| Moriyasu, Hideyuki| Sakano, Noriko| Tada, Shinya| Suzue, Takeshi| Hirao, Tomohiro| |
| Abstract | The link between changes in estimated glomerular filtration rate (eGFR) and cigarette smoking was evaluated in Japanese male workers with a 5-year follow-up. We examined the data of 456 Japanese male workers, aged 22-70 years, who were taking no medications, and from this group, 286 men (43.5±8.2 years) were followed for 5-years. Habits of cigarette smoking were obtained during interviews by well-trained staff. The influence of cigarette smoking on eGFR was evaluated. In the first analysis, there was no significant difference in eGFR between subjects with and without cigarette smoking. In the second analysis, eGFR was significantly reduced after 5 years in all subjects. Changes in eGFR in subjects with cigarette smoking (－1.90±12.31ml/min/1.73m2) were significantly smaller than those in subjects without cigarette smoking (－4.97±12.05ml/min/1.73m2). At follow-up, we found that eGFR was weakly and negatively correlated with the number of cigarettes smoked (/day). The present study indicated that cigarette smoking may be an important modifiable factor for eGFR in Japanese male workers who are not taking any medications. |
| Keywords | cigarette smoking estimated glomerular filtration rate (eGFR) male worker |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 390 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173808 |
| Web of Science KeyUT | 000285664200005 |
| JaLCDOI | 10.18926/AMO/41323 |
|---|---|
| FullText URL | 64_6_375.pdf |
| Author | Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.| |
| Abstract | This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls. |
| Keywords | diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 375 |
| End Page | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173807 |
| Web of Science KeyUT | 000285664200004 |
| JaLCDOI | 10.18926/AMO/41322 |
|---|---|
| FullText URL | 64_6_367.pdf |
| Author | Tantular, Indah S.| Matsuoka, Hiroyuki| Kasahara, Yuichi| Pusarawati, Suhintam| Kanbe, Toshio| Tuda, Josef S. B.| Kido, Yasutoshi| Dachlan, Yoes P.| Kawamoto, Fumihiko| |
| Abstract | We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383T＞C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka. |
| Keywords | Glucose-6-phosphate dehydrogenase deficiency rapid G6PD test eastern Indonesian population molecular analysis G6PD Vanua Lava |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 367 |
| End Page | 373 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173806 |
| Web of Science KeyUT | 000285664200003 |
| JaLCDOI | 10.18926/AMO/41321 |
|---|---|
| FullText URL | 64_6_359.pdf |
| Author | Yada, Yoshihiko| Sakate, Yoji| Kawamura, Yoshihiro| |
| Abstract | The results of submucosal electrocoagulation (SEC), a new radical operation for prolapsed hemorrhoids, in 403 patients with third- or fourth-degree hemorrhoids are reported. After resecting the anal skin tags that coexisted with prolapsed hemorrhoids, the hemorrhoidal varices could be resected and electrically coagulated through the wound without cutting the anal canal epithelium by using a fine needle-type electric knife. The results of this series indicated that SEC could dramatically reduce the incidence of the postoperative complications that sometimes occur after conventional hemorrhoid-ectomy, such as severe anal pain, massive anal bleeding and anal stenosis. Moreover, SEC could ensure that operated patients make an early return to social activities and have a satisfactory quality of life. Relapse of prolapsed hemorrhoids after SEC was rare. |
| Keywords | submucosal electrocoagulation method (SEC) hemorrhoids hemorrhoidectomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173805 |
| Web of Science KeyUT | 000285664200002 |
| JaLCDOI | 10.18926/AMO/41320 |
|---|---|
| FullText URL | 64_6_351.pdf |
| Author | Furumatsu, Takayuki| Asahara, Hiroshi| |
| Abstract | Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis. |
| Keywords | Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173804 |
| Web of Science KeyUT | 000285664200001 |
| JaLCDOI | 10.18926/AMO/40511 |
|---|---|
| FullText URL | 64_5_345.pdf |
| Author | Ishihara, Yoshihito| Kuroda, Shingo| Kawanabe, Noriaki| Takano-Yamamoto, Teruko| Yamashiro, Takashi| |
| Abstract | This article reports the successful surgical-orthodontic treatment of an elderly patient with dentofacial deformity and signs and symptoms of temporomandibular disorder (TMD). The patient was a 63-year-old woman with a concave profile due to mandibular protrusion. To correct skeletal deformities, the mandible was posteriorly repositioned by employing intraoral vertical ramus osteotomy (IVRO) following presurgical orthodontic treatment. After active treatment for 31 months, the facial profile was significantly improved and satisfactory occlusion was achieved. In addition, TMD symptoms of clicking sounds on the left side and difficulty in mouth opening were resolved. Regarding the findings of magnetic resonance imaging, anterior disc displacement in the opening phase was improved in the temporomandibular joint on the left side. Furthermore, stomatognathic functions were also improved without any aggravation of age-related problems. In conclusion, surgical repositioning of the mandible using IVRO leads to both morphological and functional improvements even in elderly patients. |
| Keywords | elderly patient orthodontics temporomandibular disorder intraoral vertical ramus osteotomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975769 |
| Web of Science KeyUT | 000283563300011 |
| JaLCDOI | 10.18926/AMO/40510 |
|---|---|
| FullText URL | 64_5_339.pdf |
| Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| Abstract | The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r＝－0.306, p＝0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women. |
| Keywords | systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 339 |
| End Page | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975768 |
| Web of Science KeyUT | 000283563300010 |
| JaLCDOI | 10.18926/AMO/40509 |
|---|---|
| FullText URL | 64_5_331.pdf |
| Author | Park, Se-Jin| Jung, Young-Bok| Jeong, Hwa Jae| Shin, Hun-Kyu| Jung, Ho-Joong| Lim, Jong-Jun| Yoon, Ji-Woong| Kim, Eugene| |
| Abstract | Among patients that underwent total knee arthroplasty from June, 1990 to January, 1999, 61 cases (44 patients) that could be followed for more than 10 years were included in this study. The patients were divided into a patellar retention group and a patellar resurfacing group, and were compared with regard to their clinical and radiological outcomes. In patients undergoing primary TKA, a selective patellar resurfacing protocol was used. The indications for patellar retention were a small patella, nearly normal articular cartilage, minimal preoperative patellofemoral pain, poor patellar bone quality, and young patient age. When patellar retention was performed, osteophytes of the patella were removed and marginal electrocauterization was carried out. There were 25 cases (20 patients) in the patellar retention group and 36 cases (29 patients) in the patellar resurfacing group. The mean follow-up period was 140.7 months in the patellar retention group and 149.0 months in the patellar resurfacing group. The selective patellar resurfacing with total knee arthroplasty had a favorable outcome;there were a significant difference noted between the 2 groups in the functional scores, which showed better outcomes in the patellar resurfacing group than in the patellar retention group. |
| Keywords | total knee arthroplasty (TKA) selective patellar resurfacing patellar retention patellar resurfacing |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 331 |
| End Page | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975767 |
| Web of Science KeyUT | 000283563300009 |
| JaLCDOI | 10.18926/AMO/40508 |
|---|---|
| FullText URL | 64_5_323.pdf |
| Author | Kanaoka, Yuji| Inagaki, Ei-ichirou| Hamanaka, Souhei| Masaki, Hisao| Tanemoto, Kazuo| |
| Abstract | The transient systemic low perfusion that occurs during cardiovascular surgery leads to oxidative stress and the production of free radicals. A systemic increase of various markers of oxidative stress has been shown to occur during cardiopulmonary bypass (CPB). However, these markers have not been adequately evaluated because they seem to be reactive and short-lived. Here, oxidative stress was measured using the free radical analytical system (FRAS 4) assessing the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). Blood samples were taken from 21 patients undergoing elective cardiovascular surgery. CPB was used in 15 patients, and abdominal aortic aneurysm (AAA) surgery without CPB was performed in 6. Measurements of d-ROMs and BAP were taken before surgery, 1 day, 1 week, and 2 weeks after surgery, and oxidative stress was evaluated. The d-ROM level increased gradually after cardiovascular surgery up to 2 weeks. Over time, the d-ROM level after surgery involving CPB became higher than that after AAA surgery. This difference reached statistical significance at 1 week and lasted to 2 weeks. The prolongation of CPB was prone to elevate the d-ROM level whereas the duration of the aortic clamp in AAA surgery had no relation to the d-ROM level. The BAP was also elevated after surgery, and was positively correlated with the level of d-ROMs. In this study, patients who underwent cardiovascular surgery involving CPB had significant oxidative damage. The production of ROMs was shown to depend on the duration of CPB. Damage can be reduced if CPB is avoided. When CPB must be used, shortening the CPB time may be effective in reducing oxidative stress. |
| Keywords | oxidative stress reactive oxygen metabolites (ROM) extracorporeal circulation (ECC) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975766 |
| Web of Science KeyUT | 000283563300008 |
| JaLCDOI | 10.18926/AMO/40507 |
|---|---|
| FullText URL | 64_5_317.pdf |
| Author | Myo-Khin| San-San-Oo| Khin, May Oo| Shimono, Kunio| Koide, Norio| Okada, Shigeru| |
| Abstract | We studied the prevalence of hepatitis C virus infection among blood donors from 3 hospitals of Central Myanmar and 7 hospitals of Lower Myanmar in the Yangon area, and analyzed the factors associated with the infection. The study period was from November, 2005 to June, 2007. A pre-tested questionnaire was used to obtain information on age, ethnic group, marital status, tattooing, body piercing, history of receiving transfusions, and liver diseases in self and in sexual partners. Data on seropositivity to hepatitis C, hepatitis B and human immunodeficiency virus infections were recorded. A total of 65,240 blood donors participated in the study. Their ages ranged from 18 years to 60 years (mean±SD＝29.5±9.3). The male-to-female ratio was 6：1. The prevalence of the antibody to hepatitis C was found to be 0.95% with varying rates (0.34 to 2.03) among hospitals. Females had a slightly higher rate (1.06%) than males (0.93%) (p＝0.237). Multivariate analyses revealed the following factors to be related to HCV infection:HIV infection, odds ratio (OR)＝3.0 (p＝0.003);history of liver disease, OR＝8.9 (p＝0.001);and age 30 years and above, OR＝2.6 (p＝0.001). We discuss the varying prevalences of HCV around the world. |
| Keywords | Myanmar hepatitis C prevalence blood donors associated factors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 317 |
| End Page | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975765 |
| Web of Science KeyUT | 000283563300007 |
| JaLCDOI | 10.18926/AMO/40506 |
|---|---|
| FullText URL | 64_5_307.pdf |
| Author | Kang, Hyun| Cha, Su-Man| Park, Sun-Gyoo| Jung, Yong-Hun| Woo, Young-Cheol| Kim, Jin-Yun| Koo, Gill-Hoi| Kim, Seong-Deok| Baek, Chong-Wha| |
| Abstract | It is not known whether changing from isoflurane to desflurane during the latter part of anesthesia shows early emergence and recovery in long surgery. We therefore evaluated the effects of changing isoflurane to desflurane on emergence and recovery. Eighty-two patients were randomly assigned to receive isoflurane (Group I) or desflurane (Group D) or to change from isoflurane to desflurane anesthesia (Group X). At the point when there was an hour until the operation would end, isoflurane was replaced with 1 MAC of desflurane in Group X, and isoflurane and desflurane were maintained at 1 MAC in Groups I and D. When the operation ended, we compared the emergence and recovery characteristics among the 3 groups. Compared with Group I, Group X showed faster emergence and recovery. Group X and Group D showed similar emergence and recovery. In conclusion, changing isoflurane to desflurane during the latter part of anesthesia improves emergence and recovery. |
| Keywords | desflurane isoflurane laparotomy recovery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 316 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975764 |
| Web of Science KeyUT | 000283563300006 |
