result 197 件
| Author | Takamiya, M.| Miyamoto, Y.| Yamashita, T.| Deguchi, K.| Ohta, Y.| Abe, K.| |
|---|---|
| Published Date | 2012-09-27 |
| Publication Title | Neuroscience |
| Volume | volume221 |
| Content Type | Journal Article |
| FullText URL | Autophagy_6_8_1107-1114.pdf |
|---|---|
| Author | Tian, FengFeng| Deguchi, Kentaro| Yamashita, Toru| Ohta, Yasuyuki| Morimoto, Nobutoshi| Shang, Jingwei| Zhang, Xuemei| Liu, Ning| Ikeda, Yoshio| Matsuura, Tohru| Abe, Koji| |
| Keywords | autophagy apoptosis GFP-LC3 Tg mice in vivo imaging tMCAO |
| Published Date | 2010-11-16 |
| Publication Title | Autophagy |
| Volume | volume6 |
| Issue | issue8 |
| Start Page | 1107 |
| End Page | 1114 |
| ISSN | 1554-8627 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 20930570 |
| DOI | 10.4161/auto.6.8.13427 |
| Web of Science KeyUT | 000284258900010 |
| Official Url | http://doi.org/10.4161/auto.6.8.13427| |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/49128 |
| Author | Kurata, Tomoko| Abe, Koji| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yamashita, Nobuko| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Takeuchi, Koichi| Inui, Kentaro| Fujita, Atsushi| Takeuchi, Nao| Abe, Shuya| |
|---|---|
| Published Date | 2005-09-30 |
| Publication Title | 情報処理学会研究報告. 自然言語処理研究会報告 |
| Volume | volume2005 |
| Issue | issue94 |
| Content Type | Technical Report |
| Author | Abe, Daigo| |
|---|---|
| Published Date | 2011-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Ikeda, Yoshio| Abe, Koji| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2009-09-18 |
| Publication Title | Journal of Biomechanics |
| Volume | volume42 |
| Issue | issue13 |
| Content Type | Journal Article |
| Author | Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-11-12 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume402 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/46846 |
|---|---|
| FullText URL | 65_4_219.pdf |
| Author | Yamashita, Toru| Abe, Koji| |
| Abstract | Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain. |
| Keywords | cerebral ischemia hemorrhagic transformation activator free radical matrix metalloproteinase-9 |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-08 |
| Volume | volume65 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21860527 |
| Web of Science KeyUT | 000294236700001 |
| Author | Shimamura, Yasunori| Inoue, Madoka| Ozawa, Masatugu| Kanazawa, Tomoko| Saitou, Taiichi| Nakahara, Ryuichi| Noda, Tomoyuki| Nishida, Keiichiro| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Abe, Tsukasa| |
|---|---|
| Published Date | 2009-03 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume25 |
| Content Type | Others |
| Author | Shimizu, M.| Miki, Y.| Asanuma, K.| Abe, K.| Miyagawa, F.| |
|---|---|
| Published Date | 1937-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Murakami, S.| Miki, Y.| Abe, T.| |
|---|---|
| Published Date | 1937-03-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Abe, Nobuhiro| |
|---|---|
| Published Date | 2011-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Abe, Takatomo| |
|---|---|
| Published Date | 1941-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume53 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Abe, Takatomo| |
|---|---|
| Published Date | 1941-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume53 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Yamashita, Toru| Kamiya, Tatsushi| Deguchi, Kentaro| Inaba, Toshiki| Zhang, Hanzhe| Shang, Jingwei| Miyazaki, Kazunori| Ohtsuka, Aiji| Katayama, Yasuo| Abe, Koji| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 阿部 芳郎| 富樫 孝志| |
|---|---|
| Published Date | 1996-02-29 |
| Publication Title | 岡山大学構内遺跡発掘調査報告 |
| Volume | volume10 |
| Content Type | Research Paper |
| Author | 富樫 孝志| 山本 悦世| 阿部 芳郎| |
|---|---|
| Published Date | 1995-03-31 |
| Publication Title | 岡山大学構内遺跡発掘調査報告 |
| Volume | volume8 |
| Content Type | Research Paper |
