result 9304 件
| JaLCDOI | 10.18926/14943 |
|---|---|
| Title Alternative | Interferon and pancreatitis |
| FullText URL | 070_084_087.pdf |
| Author | Ochi, Koji| Matsumura, Naoki| Mizushima, Takaaki| Hasuoka, Hideaki| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ |
| Keywords | インターフェロン (interferon) 急性膵炎 (acute pancreatitis) 慢性膵炎 (chronic pancreatitis) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 84 |
| End Page | 87 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308150 |
| JaLCDOI | 10.18926/14942 |
|---|---|
| Title Alternative | 臨床的および実験的側面からみた慢性膵炎とフリーラジカル |
| FullText URL | 070_079_083.pdf |
| Author | Ochi, Koji| Matsumura, Naoki| Mizushima, Takaaki| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. |
| Keywords | 慢性膵炎 (chronic pancreatitis) フリーラジカル (free radicals) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 79 |
| End Page | 83 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308147 |
| JaLCDOI | 10.18926/14941 |
|---|---|
| Title Alternative | Analysis of Factors Regarding Spa Therapy in Patients with Rheumatoid Arthritis |
| FullText URL | 070_073_078.pdf |
| Author | Yoshio, Keiko| Taguma, Masae| Noumi, Mayumi| Nakamura, Sumie| Harada, Seishi| Tanizaki, Yoshiro| |
| Abstract | 1998年4月より9月までの6ヶ月間に当院へ入院し温泉療法をうけた慢性関節リウマチ患者6例を対象に,温泉治療経験の有無,年齢,機能障害度(クラス),罹患年数の4項目が温泉療法効果に及ぼす影響につき検討した｡温泉治療経験の有無では治療経験を有する患者においてMHAQ(modified health assessment questionnaile),患者による疼痛評価,患者による全般活動性評価に有意な改善が見られ,年齢(75才以上,75才未満)では,75才未満においてMHAQに有意な改善傾向が見られた｡機能障害度(クラス3以上,クラス2以下),罹患年数(15年以上,15年未満)においては有意差は見られなかった｡温泉の永続効果を保つためには,年1～2回の入院を繰り返すことが効果的であることが示唆された｡ |
| Keywords | 慢性関節リウマチ 温泉療法 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 73 |
| End Page | 78 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308424 |
| JaLCDOI | 10.18926/14936 |
|---|---|
| Title Alternative | 腰椎MRI画像と腰痛の関係 |
| FullText URL | 070_067_072.pdf |
| Author | Takata, Shingo| Yumoto, Eiichirou| Okamoto, Makoto| Tsugeno, Hirofumi| Harada, Seishi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Harada, Mine| |
| Abstract | The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on). |
| Keywords | MRI (Magnetic resonance imaging) 腰椎 (Lumbar spine) 椎間板変性 (Disc disease) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 67 |
| End Page | 72 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308559 |
| JaLCDOI | 10.18926/14935 |
|---|---|
| Title Alternative | A Case of Recurrent Churg-Strauss Syndrome Associated with Bronchial Asthma |
| FullText URL | 070_061_066.pdf |
| Author | Harada, Seishi| Tsugeno, Hirofumi| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Okamoto, Makoto| Takata, Shingo| Yamamoto, Toshio| Tanizaki, Yoshiro| |
| Abstract | 入院中にChurg-Strauss症候群の再燃を来した症例を報告した｡症例は気管支喘息を有する73歳の女性で,持続する両下肢の知覚障害を主訴に当院に入院した｡入院2週頃より微熱,下腹部不快感が続き右下肢のdrop foot,下血を呈した｡末梢血では著明な好酸球増多を認め,内視鏡検査で直腸潰瘍を認めた。3年前の両下肢の知覚障害出現時にも同様の症状を経験しており,Churg-Strauss症候群の再燃と診断し,ステロイド治療を開始することにより新たな後遺症を残すことなく寛解に至った｡Churg-Strauss症候群の発症･再燃の機序を考える上で貴重な症例と考え,文献的考察を加え報告する｡ |
| Keywords | Churg-Strauss症候群 (Churg-Strauss syndrome) アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) 血管炎症候群 (vasculitis syndrome) 気管支喘息 (bronchial asthma) 好酸球増多 (eosinophilia) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 61 |
| End Page | 66 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308532 |
| JaLCDOI | 10.18926/14934 |
|---|---|
| Title Alternative | 気管支喘息症例における皮質骨海綿化 |
| FullText URL | 070_053_060.pdf |
| Author | Tsugeno, Hirofumi| Nakai, Mutsuro| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Akiyama, Tsuneo| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences. |
| Keywords | bronchial asthma systemic glucocorticoid cortical bone cortical porosity peripheral quantitative computed tomography |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 53 |
| End Page | 60 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308477 |
| JaLCDOI | 10.18926/14933 |
|---|---|
| Title Alternative | 気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子 |
| FullText URL | 070_043_052.pdf |
| Author | Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Takada, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Niiya, Kenji| Harada, Mine| |
| Abstract | Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation. |
| Keywords | エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 43 |
| End Page | 52 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308623 |
| JaLCDOI | 10.18926/14927 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 |
| FullText URL | 070_036_042.pdf |
| Author | Hosaki, Yasuhiro| Takata, Shingo| Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The body surface peripheral circulation in 12 cases, including 9 patients with diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3
healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p |
| Keywords | サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 36 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308240 |
| JaLCDOI | 10.18926/14926 |
|---|---|
| Title Alternative | 気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討 |
| FullText URL | 070_028_035.pdf |
| Author | Mifune, Takashi| Takata, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Harada, Seishi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine| |
| Abstract | Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms. |
| Keywords | 気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 28 |
| End Page | 35 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308098 |
| JaLCDOI | 10.18926/14925 |
|---|---|
| Title Alternative | 気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義 |
| FullText URL | 070_017_027.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Nakai, Mutsuo| Tanizaki, Yoshiro| |
| Abstract | The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT
number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung.
We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p |
| Keywords | low attenuation area high resolution computed tomography reversible airway obstruction |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 17 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308175 |
| JaLCDOI | 10.18926/14922 |
|---|---|
| Title Alternative | Ⅰ型アレルギー反応および副腎皮質ホルモンは気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生に影響をおよぼす |
| FullText URL | 070_009_016.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Ochi, Koji| Koide, Norio| |
| Abstract | The generation. of leukotrienes 84 (LT84) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 71 patients with asthma (42 with atopic and 29 with nonatopic asthma) and 23 healthy controls. Of these patients,22 had SDIA (steroid-dependent intractable asthma). 1. The generation of LT84 and LTC4 by leucocytes was significantly more enhanced in patients with atopic, non-SOIA asthma than in healthy subjects, but not in patients with nonatopic asthma. The generation of LT84 and LTC4 in atopic asthma was significantly more decreased in patients with SOIA than in those with non-SOIA. 2. The LTC4 generation was significantly larger in attack stage than in attack-free stage of patients with atopic and nonatopic asthma when they had not SOIA. However, no significant difference was found in LT84 generation between attack and nonattack stages in these patients. 3. In patients with SOIA, no significant differences were observed in the generation of LT84 and LTC4 between attack and nonattack stages. The results suggest that IgE-mediated allergy and asthma attacks enhance and glucocorticoids inhibit the generation of LT84 and LTC4 by leucocytes. |
| Keywords | bronchial asthma LT84 LTC4 IgE-mediated allergy glucocorticoids |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308654 |
| JaLCDOI | 10.18926/14921 |
|---|---|
| Title Alternative | Spa therapy for patients with asthma. A study on 437 patients with asthma admitted for last 5 years. |
| FullText URL | 070_001_008.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Ochi, Koji| |
| Abstract | 1994年1月より1998年12月までの5年間に当院へ入院した呼吸器疾患のなかで気管支喘息を対象に,年齢,地域分布などの経年変化について検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は664例で,このうち,気管支喘息は437例(65.8% )であった｡呼吸器疾患のなかで気管支喘息に占める割合の経年変化では,1995年度が最も高く(74.4% ),1997,1998年度にはやや低下(ともに60.7% )の傾向が見られた｡2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,いずれの年度においても50% 以上(平均57.3% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛県などからの入院症例が多い傾向か見られた。3.年齢別検討では,いずれの地域においても,高齢者の入院症例か多く,鳥取県内では70才以上の症例の頻度(平均35.1% )が,また遠隔地(鳥取県外)では60-69才の症例の頻度(平均37.7% )が高い傾向か見られた｡ |
| Keywords | 気管支喘息 (asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308420 |
| JaLCDOI | 10.18926/14917 |
|---|---|
| FullText URL | 071_094_095.pdf |
| Author | Nakamura, Sumie| |
| Keywords | 看護部 入院状況 運動器疾患 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 94 |
| End Page | 95 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308355 |
| JaLCDOI | 10.18926/14915 |
|---|---|
| FullText URL | 071_089_093.pdf |
| Author | 石田 美枝子| |
| Abstract | 通院患者の温泉プール利用者95名を対象にアンケート調査し，主に訓練に対する満足度と期待度について調査した。 結果は有効回答85名，対象者の年齢65歳以上58名（68％）65歳末満27名（32％），疾患別では呼吸器疾患39名（45．9％）療病性疾患29名（34．1％）その他の疾患17名（20％）であった。 t検定の結果有意差（P＜0．05）があったのは，療病性疾患群では呼吸器疾患群に比べ期待度が高い，訓練が頻回な群で期待度が高い，指導あり群で満足度が高い，であった。年齢別での効果では65歳末満と65歳以上の比較で有意差はなかったが，高齢者（65歳以上）において高い傾向が見られた。温泉プール訓練は高齢者に効果的な訓練と考えられ，より効果を高めるための課題として訓練指導を充実する必要がある。 |
| Keywords | 温泉プール訓練 外来通院患者 満足度 期待度 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 89 |
| End Page | 93 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308152 |
| JaLCDOI | 10.18926/14914 |
|---|---|
| Title Alternative | Evaiuation of spa therapy by questionnaire. Characteristics of patients from distant areas. |
| FullText URL | 071_084_088.pdf |
| Author | Nishimura, Nobuko| Terasaki, Kayo| Yamamoto, Sadae| Yoshio, Keiko| Nakamura, Sumie| Tanizaki, Yoshiro| |
| Abstract | 1999年4月～12月の9ケ月間の遠隔地からの入院患者80名（痔痛性疾患47例，呼吸器疾患33例）を対象に，岡大三朝分院に来院した動機，入院前の状態，温泉療法の効果，薬剤の変化，退院決定の動機等について退院前にアンケート調査を行い検討を加えた。対象症例の年齢は60才以上の高齢者力て多く，入院期間は1ケ月～2ケ月末満が多い傾向であった。入院前の状態では，今までの治療に不満，限界を感じて来院している症例が71例（88．7％）を占めていた。地域別では広島，大阪，京都，兵庫からの来院か多く，その他18都府県に及んでいた。アンケート結果では，疾患別による若干の傾向と，温泉療法に対する評価として症状の改善が見られ，また，使用薬剤の減量の可能性が示唆された。 |
| Keywords | 遠隔地 (distant area) 温泉療法 (spa therapy) アンケート (questionaire) 呼吸器疾患 (respiratory disease) 疼痛性疾患 (pain disease) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 84 |
| End Page | 88 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308118 |
| JaLCDOI | 10.18926/14913 |
|---|---|
| Title Alternative | マトリックスメタロプロテアーゼと膵疾患 |
| FullText URL | 071_076_083.pdf |
| Author | Yokoyama, Motohiro| Ochi, Koji| Mizushima, Takaaki| Ichimura, Mitsuko| Tsurumi, Tetsuya| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. |
| Keywords | matrix metalloproteinase(MMP) tissue inhibitor of metalloproteinase(TIMP) pancreatic cancer (膵癌) chronic pancreatitis (慢性膵炎) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 76 |
| End Page | 83 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308587 |
| JaLCDOI | 10.18926/14912 |
|---|---|
| FullText URL | 071_073_075.pdf |
| Author | Ashida, Kozo| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Nishida, Norikazu| Okamoto, Makoto| Takata, Shingo| Tanizaki, Yoshiro| Tsuji, Takao| |
| Abstract | 症例は80才，女性。76才時［平成7年11月］より肝機能異常［アルカリフォスファターゼ高値］を認め，肝機能異常出現1年7ケ月後，血清学的検索で原発性胆汁性肝硬変症が疑われたが，無治療にて外来で経過を観察を行った。アルカリフォスファターゼ値は漸増傾向を示し，トランスアミナーゼ値の異常も伴ってきたため，平成12年11月精査目的で入院。組織検査等で無症候性原発性胆汁性肝硬変症［PBC］と診断した。PBCは中年・女性に好発する疾患で，高齢【特に後期高齢者］での発症は極めて稀である。4年間の自然経過も含め，興味深いと考えられたので報告する。 |
| Keywords | 原発性胆汁性肝硬変症 (primary biliary cirrhosis) 高齢 (elderly) 自然経過 (natural course) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 73 |
| End Page | 75 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308230 |
| JaLCDOI | 10.18926/14911 |
|---|---|
| Title Alternative | A case of systemic lupus erythematosus (SLE) associated with disseminated intravascular coagulation (DIC) |
| FullText URL | 071_068_072.pdf |
| Author | Takata, Singo| Okamoto, Makoto| Tsugeno, Hirofumi| Harada, Seishi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Niiya, Kenji| Harada, Mine| |
| Abstract | 播種性血管内凝固症候群（DIC）を合併した全身性エリテマトーデス（SLE）を経験したので報告する。症例は73歳女性。64歳時慢性関節リウマチ（RA）と診断された。1999年1月食欲低下を訴え当科受診した。血小板減少、FDP高値、PT上昇等よりDIC発症を疑った。膠原病では凝固系の異常を認めるが、本症例では凝固系が完進しDICを来したと考えられた。 本症例はリウマチ因子陽性であったが、朝のこわばり等典型的なRAの所見に乏しく他の膠原病の合併を疑い、腎障害、血小板減少、抗Sm抗体、抗核抗体陽性よりSLEと診断した。 |
| Keywords | 慢性関節リウマチ (Rheumatoid arthritis) 全身性エリテマトーデス (Systemic lupus erythematosus) 播種性血管内凝固症候群 (Disseminated intravascular coagulation syndrome) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 68 |
| End Page | 72 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308643 |
| JaLCDOI | 10.18926/14910 |
|---|---|
| Title Alternative | ステロイド依存性気管支喘息症例の病的骨折と皮質骨傷害の検討 |
| FullText URL | 071_059_067.pdf |
| Author | Tsugeno, Hirofumi| Goto, Bunrei| Nakai, Mutsuro| Okamoto, Makoto| Takata, Singo| Mifune, Takashi| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Ashida, Kozo| Akiyama, Tsuneo| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | In a previous study, we demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD) and induces development of pathologic fractures in asthmatic patients. To investigate cortical bone porosity due to glucocorticoids, we studied cortical bone volume, BMD, bone strength, and fractures in patients with asthma in this report. A total of 82 postmenopausal asthmatic patients were enrolled in the study. Vertebral fractures were diagnosed via plain spinal radiograms. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD, relative cortical volume, and Strength Strain Index (SSI). Multiple regression analysis, Student's t test, and other statistical analyses were performed. Patients with systemic glucocorticoids therapy had lower cortical BMD, relative cortical volume, SSI, and more number of vertebral fractures than patients without it. Lifetime cumulative dose of glucocorticoids was related to cortical BMD, relative cortical volume, SSI, and the number of vertebral fractures. The cortical volumedensity relationship appeared to remain constant regardless of systemic glucocorticoid administration. The number of vertebral fractures correlated highly with cortical BMD, relative cortical volume, and SSI at the radius. In conclusion, systemic glucocorticoid administration decreases cortical bone density, cortical bone volume, and bone strength. G lucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites. Given that both cortical bone density and volume provide bone strength, cortical bone porosity was seen to contribute to glucocorticoid - induced bone strength loss and fractures. |
| Keywords | glucocorticoid cortical bone pQCT osteoporosis |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 59 |
| End Page | 67 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308222 |
| JaLCDOI | 10.18926/14909 |
|---|---|
| Title Alternative | 脂肪の変化と関連した気管支喘息に対するn－3系脂肪酸食の効果 ― n－6系脂肪酸との比較 |
| FullText URL | 071_050_058.pdf |
| Author | Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Takata, Shingo| Tanizaki, Yoshiro| Harada, Mine| |
| Abstract | N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids. |
| Keywords | perilla seed oil (エゴマ抽) a -1inolenic acid (α－リノレン酸) leukotriene C4 (ロイコトリエンC4) respiratory function (呼吸機能) 脂質代謝 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 50 |
| End Page | 58 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308088 |
