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JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL 46_443.pdf
Author 湯本 泰弘| 花房 直志| 永松 知洋| 岡田 茂|
Keywords low level radioactive sample (LLRS) experimental incineration system for LLRS
Published Date 1997-7-15
Publication Title Radioisotopes
Volume volume46
Issue issue7
Publisher 日本アイソト-プ協会
Start Page 443
End Page 449
ISSN 00338303
NCID AN00351589
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
NAID 10003721742
FullText URL fulltext.pdf
Author Okamoto, Yasuhiro| Ouyang, Zhiyong| Fujiwara, Takumi| Okada, Akira|
Keywords Picosecond pulsed laser Glass material Numerical aperture Bending strength Breaking stress
Note This is a post-peer-review, pre-copyedit version of an article published in Welding in the World. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40194-020-00877-4.|
Published Date 2020-03-13
Publication Title Welding in the World
Volume volume64
Issue issue6
Publisher Springer
Start Page 937
End Page 947
ISSN 0043-2288
NCID AA00887226
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1007/s40194-020-00877-4
Web of Science KeyUT 000553661200002
Related Url isVersionOf https://doi.org/10.1007/s40194-020-00877-4
FullText URL fulltext.pdf
Author Uchida, Daisuke| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Okada, Hiroyuki|
Keywords oxidative stress chronic hepatitis hepatocellular carcinoma
Published Date 2020-05-28
Publication Title Nutrients
Volume volume12
Issue issue6
Publisher MDPI
Start Page 1576
ISSN 2072-6643
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32481552
DOI 10.3390/nu12061576
Web of Science KeyUT 000554005200001
Related Url isVersionOf https://doi.org/10.3390/nu12061576
FullText URL fulltext.pdf
Author Tanabe, Katsuyuki| Kanzaki, Hiromitsu| Wada, Takahira| Nakashima, Yuri| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Keywords case report gastric cancer IgA nephropathy nivolumab steroid
Published Date 2020-05-22
Publication Title Medicine
Volume volume99
Issue issue21
Publisher Lippincott, Williams & Wilkins
Start Page e20464
ISSN 0025-7974
NCID AA00728867
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 the Author(s).
File Version publisher
PubMed ID 32481351
DOI 10.1097/MD.0000000000020464
Web of Science KeyUT 000551508200106
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000020464
FullText URL fulltext.pdf
Author Yamamoto, Shumpei| Onishi, Hideki| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Shiraha, Hidenori| Okada, Hiroyuki|
Keywords Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin
Published Date 2020-04-21
Publication Title Gastrointestinal Tumors
Volume volume7
Issue issue3
Publisher Karger
Start Page 83
End Page 92
ISSN 2296-3774
NCID AA12665877
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s)
File Version publisher
DOI 10.1159/000506941
Web of Science KeyUT 000551254300003
Related Url isVersionOf https://doi.org/10.1159/000506941
FullText URL fulltext.pdf
Author Du, Juan| Xu, Yanning| Sasada, Saki| Oo, Aung Ko Ko| Hassan, Ghmkin| Mahmud, Hafizah| Khayrani, Apriliana Cahya| Alam, Md Jahangir| Kumon, Kazuki| Uesaki, Ryo| Afify, Said M.| Mansour, Hager M.| Nair, Neha| Zahra, Maram H.| Seno, Akimasa| Okada, Nobuhiro| Chen, Ling| Yan, Ting| Seno, Masaharu|
Keywords 2020-06-22
Published Date 2020-06-22
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher NATURE PUBLISHING GROUP
Start Page 9955
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32572057
DOI 10.1038/s41598-020-66471-2
Web of Science KeyUT 000543963100001
Related Url isVersionOf https://doi.org/10.1038/s41598-020-66471-2
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Murakami, Toshi| Tanaka, Takehiro| Oka, Shohei| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Published Date 2020-06-04
Publication Title Case Reports in Gastrointestinal Medicine
Volume volume2020
Publisher Hindawi
Start Page 6381670
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Masaya Iwamuro et al.
File Version publisher
PubMed ID 32566328
DOI 10.1155/2020/6381670
Web of Science KeyUT 000542326600001
Related Url isVersionOf https://doi.org/10.1155/2020/6381670
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Miyahara, Koji| Sakaguchi, Chihiro| Takenaka, Ryuta| Kobayashi, Sayo| Mouri, Hirokazu| Tanaka, Shigetomi| Toyokawa, Tatsuya| Tanaka, Shouichi| Nishimura, Mamoru| Yamauchi, Kenji| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords 18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma
Published Date 2020-05-01
Publication Title Journal of Clinical Medicine
Volume volume9
Issue issue5
Publisher MDPI
Start Page 1301
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32370028
DOI 10.3390/jcm9051301
Web of Science KeyUT 000540223800058
Related Url isVersionOf https://doi.org/10.3390/jcm9051301
FullText URL fulltext.pdf
Author Du, Juan| Seno, Akimasa| Sasada, Saki| Xu, Yanning| Oo, Aung Ko Ko| Hassan, Ghmkin| Ueno, Shunsuke| Afify, Said M.| Zahra, Maram H| Okada, Nobuhiro| Chen, Ling| Fu, Xiaoying| Tokutaka, Heizo| Yan, Ting| Seno, Masaharu|
Keywords miPSCs CSCs CCR6 CCL20
Published Date 2020
Publication Title Journal of Research in Medical and Dental Science
Volume volume8
Issue issue1
Publisher Amber Publication
Start Page 200
End Page 207
ISSN 2347-2367
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
Web of Science KeyUT 000518402400030
Related Url isVersionOf https://www.jrmds.in/abstract/upregulated-ccl20-and-ccr6-in-cancer-stem-cells-converted-from-mouse-ips-cells-52887.html
JaLCDOI 10.18926/AMO/59958
FullText URL 74_3_245.pdf
Author Yamamoto, Shumpei| Takayama, Hiroshi| Shimodate, Yuichi| Takezawa, Rio| Nishimura, Naoyuki| Doi, Akira| Mouri, Hirokazu| Matsueda, Kazuhiro| Mizuno, Motowo| Okada, Hiroyuki|
Abstract Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
Keywords vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 245
End Page 250
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577023
Web of Science KeyUT 000543363400008
NAID 120006862799
reference Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, Doi T, Otani Y, Fujisaki J, Ajioka Y, Hamada T, Inoue H, Gotoda T and Yoshida S: A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer (2006) 9: 262-270.| Lian J, Chen S, Zhang Y and Qiu F: A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer. Gastrointest Endosc (2012) 76: 763-770.| Park YM, Cho E, Kang HY and Kim JM: The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis. Surg Endosc (2011) 25: 2666-2677.| Goto O, Fujishiro M, Oda I, Kakushima N, Yamamoto Y, Tsuji Y, Ohata K, Fujiwara T, Fujiwara J, Ishii N, Yokoi C, Miyamoto S, Itoh T, Morishita S, Gotoda T and Koike K: A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. Dig Dis Sci (2012) 57: 435-439.| Tsuji Y: Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions. World Journal of Gastroenterology (2010) 16: 2913.| Furuhata T, Kaise M, Hoteya S, Iizuka T, Yamada A, Nomura K, Kuribayashi Y, Kikuchi D, Matsui A, Ogawa O, Yamashta S and Mitani T: Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy. Gastric Cancer (2017) 20: 207-214.| Okada K, Yamamoto Y, Kasuga A, Omae M, Kubota M, Hirasawa T, Ishiyama A, Chino A, Tsuchida T, Fujisaki J, Nakajima A, Hoshino E and Igarashi M: Risk factors for delayed bleeding after endoscopic submucosal dissection for gastric neoplasm. Surg Endosc (2011) 25: 98-107.| Dong J, Wei K, Deng J, Zhou X, Huang X, Deng M and Lu M: Effects of antithrombotic therapy on bleeding after endoscopic submucosal dissection. Gastrointest Endosc (2017) 86: 807-816.| Kono Y, Obayashi Y, Baba Y, Sakae H, Gotoda T, Miura K, Kanzaki H, Iwamuro M, Kawano S, Kawahara Y, Tanaka T and Okada H: Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy. J Gastroenterol Hepatol (2018) 33: 453-460.| Tounou S, Morita Y and Hosono T: Continuous aspirin use does not increase post-endoscopic dissection bleeding risk for gastric neoplasms in patients on antiplatelet therapy. Endosc Int Open (2015) 3: E31-38.| Gotoda T, Hori K, Iwamuro M, Kono Y, Miura K, Kanzaki H, Kawano S, Kawahara Y and Okada H: Evaluation of the bleeding risk with various antithrombotic therapies after gastric endoscopic submucosal dissection. Endosc Int Open (2017) 5: E653-E662.| Uedo N, Takeuchi Y, Yamada T, Ishihara R, Ogiyama H, Yamamoto S, Kato M, Tatsumi K, Masuda E, Tamai C, Yamamoto S, Higashino K, Iishi H and Tatsuta M: Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. Am J Gastroenterol (2007) 102: 1610-1616.| Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K and Shimokawa T: Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study. J Gastroenterol (2018).| Kagawa T, Iwamuro M, Ishikawa S, Ishida M, Kuraoka S, Sasaki K, Sakakihara I, Izumikawa K, Yamamoto K, Takahashi S, Tanaka S, Matsuura M, Hasui T, Wato M and Inaba T: Vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. Aliment Pharmacol Ther (2016) 44: 583-591.| Kato M, Uedo N, Hokimoto S, Ieko M, Higuchi K, Murakami K and Fujimoto K: Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants. Dig Endosc (2018) 30: 433-440.| Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T and Japan Gastroenterological Endoscopy S: Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc (2014) 26: 1-14.| Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y, Ashida K and Sugano K: Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut (2018) 67: 1033-1041.|
JaLCDOI 10.18926/AMO/59957
FullText URL 74_3_237.pdf
Author Oyama, Atsushi| Uchida, Daisuke| Shiraha, Hidenori| Sawahara, Hiroaki| Kato, Ryo| Iwamuro, Masaya| Horiguchi, Shigeru| Okada, Hiroyuki|
Abstract The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.
Keywords enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 237
End Page 243
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577022
Web of Science KeyUT 000543363400007
NAID 120006862798
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Ota, Yoko| Tanaka, Takehiro| Asada, Noboru| Yano, Shuya| Uka, Mayu| Nakamura, Rei| Baba, Yuki| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Published Date 2020-04-09
Publication Title Case Reports in Gastrointestinal Medicine
Volume volume2020
Publisher Hindawi
Start Page 7947540
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Masaya Iwamuro et al.
File Version publisher
PubMed ID 32328319
DOI 10.1155/2020/7947540
Web of Science KeyUT 000528921300002
Related Url isVersionOf https://doi.org/10.1155/2020/7947540
File URL 10496hagawaritobosigara.jpg e-hagawaritobosigara.jpg
APG3family イネ科 (Poaceae)
YList ylist.info/ylist_detail_display.php?pass=13756
Database Naturalized plants in Japan : Seed-Image database
Database(alternative) Naturalized plants in Japan : Seed-Image database
Publisher 岡山大学 資源植物科学研究所 野生植物グループ
Resource Type Data or Dataset
Official URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
File URL 10498himedandangikyou.jpg k-himedandangikyou.jpg
APG3family キキョウ科 (Campanulaceae)
YList ylist.info/ylist_detail_display.php?pass=10115
Database Naturalized plants in Japan : Seed-Image database
Database(alternative) Naturalized plants in Japan : Seed-Image database
Publisher 岡山大学 資源植物科学研究所 野生植物グループ
Resource Type Data or Dataset
Official URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
FullText URL text_correction.pdf table3_correction.pdf
Author Tomoda, Takeshi | Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Note Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y|
Published Date 2020-02-06
Publication Title Surgical Endoscopy
Volume volume35
Issue issue1
Publisher Springer
Start Page 239
End Page 240
ISSN 09302794
NCID AA10750363
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32030547
DOI 10.1007/s00464-020-07399-6
Web of Science KeyUT 000515963500002
Related Url isVersionOf https://doi.org/10.1007/s00464-020-07399-6
FullText URL fulltext.pdf table.pdf
Author Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| chida, Daisuke| atsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Keywords Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy
Note This fulltext is aailable in Jan. 2021.|
Published Date 2020-01-16
Publication Title Surgical Endoscopy
ISSN 09302794
NCID AA10750363
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31950273
DOI 10.1007/s00464-020-07385-y
Web of Science KeyUT 000507705600001
Related Url isVersionOf https://doi.org/10.1007/s00464-020-07385-y
FullText URL fulltext.pdf
Author Uno, Soichiro| Okada, Masahiro| Taketa, Hiroaki| Torii, Yasuhiro| Matsumoto, Takuya|
Keywords Highly translucent partially stabilized zirconia Monoclinic phase Biaxial flexural strength Thermal treatment
Published Date 2020-03-27
Publication Title Dental Materials Journal
Volume volume39
Issue issue2
Publisher Japanese Society for Dental Materials and Devices
Start Page 295
End Page 301
ISSN 0287-4547
NCID AA10443149
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Japanese Society for Dental Materials and Devices
File Version publisher
PubMed ID 31827055
DOI 10.4012/dmj.2018-415
Related Url isVersionOf https://doi.org/10.4012/dmj.2018-415
Title Alternative Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
FullText URL 131_139.pdf
Author 三浦 公| Iwamuro, Masaya| Toyokawa, Tatsuya| Takenaka, Ryuta| Inoue, Masafumi| Ito, Mamoru| Okada, Hiroyuki|
Abstract To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
Keywords 機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide)
Publication Title Journal of Okayama Medical Association
Published Date 2019-12-02
Volume volume131
Issue issue3
Start Page 139
End Page 143
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.139
language Japanese
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.139
NAID 130007782646
FullText URL fulltext.pdf
Author Uchida, Daisuke| Kato, Hironari| Matsumoto, Kazuyuki| Ishihara, Yuki| Matsumi, Akihiro| Saragai, Yosuke| Takada, Saimon| Yabe, Shuntaro| Muro, Shinichiro| Tomoda, Takeshi| Horiguchi, Shigeru| Okada, Hiroyuki|
Keywords Endoscopic ultrasound Diagnostic screening program Pancreatic diseases Biliary tract diseases
Published Date 2019-12-18
Publication Title BMC Gastroenterology
Volume volume19
Issue issue1
Publisher BMC
Start Page 220
ISSN 1471-230X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2019
File Version publisher
PubMed ID 31852458
DOI 10.1186/s12876-019-1141-7
Web of Science KeyUT 000510482800002
Related Url isVersionOf https://doi.org/10.1186/s12876-019-1141-7