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JaLCDOI 10.18926/AMO/56645
FullText URL 73_2_101.pdf
Author Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo|
Abstract Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
Keywords sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 101
End Page 107
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015744
JaLCDOI 10.18926/AMO/56644
FullText URL 73_2_95.pdf
Author Ercan, Sabriye| Başkurt, Ferdi| Başkurt, Zeliha| Çetin, Cem|
Abstract The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at
Keywords fatigue obesity mobility balance woman
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 100
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015743
JaLCDOI 10.18926/AMO/56458
FullText URL 73_1_51.pdf
Author Fujii, Masakuni| Fujimoto, Kenji| Yabe, Syuntaro| Nasu, Junichiro| Miyaike, Jiro| Yoshioka, Masao| Shiode, Junji| Yamamoto, Kazuhide| Matsuda, Shinya|
Abstract  We investigated the relationship between body mass index (BMI) and postoperative outcomes in 450 gallbladder cancer patients in Japan. We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. We classified patient BMIs as underweight (BMI<18.5 kg/m2), normal (BMI≥18.5 kg/m2 and <25 kg/m2) or overweight/obese (BMI≥25 kg/m2), then investigated the relationship between these categories and two postoperative outcomes: time to discharge and postoperative Medicare fees. The median postoperative time to discharge was 12 days in all patients, and 12 days in each of the three weight groups (p=0.62, n.s.). The median postoperative Medicare fees from surgery until discharge were (USD): all patients, $5,002; underweight, $5,875; normal weight, $4,797; and overweight/obese, $5,179 (p=0.146, n.s.). A multivariate analysis with adjustment for competing risk factors revealed that BMI was not associated with increased risk of longer postoperative time to discharge (normal weight: HR 1.17, p=0.29; overweight/obese: HR 1.17, p=0.37) or higher postoperative Medicare fees (OR 0.99, p=0.86, n.s.). Thus, high BMI was not found to be a factor for poor postoperative outcomes in Japanese patients with gallbladder cancer.
Keywords body mass index gallbladder cancer surgery obesity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 51
End Page 59
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820054
JaLCDOI 10.18926/AMO/56455
FullText URL 73_1_21.pdf
Author Oiwa, Yuko| Watanabe, Toyohiko| Sadahira, Takuya| Ishii, Ayano| Sako, Tomoko| Inoue, Miyabi| Wada, Koichiro| Kobayashi, Yasuyuki| Araki, Motoo| Nasu, Yasutomo|
Abstract We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction.
Keywords clitoris pelvic organ prolapse Doppler ultrasound
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 21
End Page 27
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820051
JaLCDOI 10.18926/AMO/56454
FullText URL 73_1_15.pdf
Author Shioji, Naohiro| Kanazawa, Tomoyuki| Iwasaki, Tatsuo| Shimizu, Kazuyoshi| Suemori, Tomohiko| Kuroe, Yasutoshi| Morimatsu, Hiroshi|
Abstract We compared the reintubation rate in children who received high-flow nasal cannula (HFNC) therapy to the rate in children who received noninvasive ventilation (NIV) therapy for acute respiratory failure (ARF) after cardiac surgery. This was a retrospective analysis of 35 children who received HFNC therapy for ARF after cardiac surgery in 2014-2015 (the HFNC group). We selected 35 children who had received NIV therapy for ARF after cardiac surgery in 2009-2012 as a control group. The matching parameters were body weight and risk adjustment for congenital heart surgery category 1. The reintubation rate within 48 h in the HFNC group tended to be lower than that in the NIV group (3% vs. 17%, p=0.06). The reintubation rate within 28 days was significantly lower in the HFNC group compared to the NIV group (3% vs. 26%, p=0.04). The HFNC group’s ICU stays were significantly shorter than those of the NIV group: 10 (IQR: 7-17) days vs. 17 (11-32) days, p=0.009. HFNC therapy might be associated with a reduced reintubation rate in children with ARF after cardiac surgery.
Keywords high-flow nasal cannula noninvasive ventilation reintubation congenital heart disease acute respiratory failure
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 15
End Page 20
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820050
JaLCDOI 10.18926/AMO/56453
FullText URL 73_1_7.pdf
Author Fukumori, Norio| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Kurata, Tsuyoshi| Sakanishi, Yuta| Sugioka, Takashi| Mawatari, Masaaki|
Abstract We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10.5 years (30% male) who had undergone a THA (Oct. 2014 to Feb. 2015) at our hospital. The control patients were administered the standard analgesic protocol: flurbiprofen axetil as a continuous intravenous infusion and oral celecoxib (NAPAP; n=109). The patients in the new analgesic protocol group received IV APAP in addition to the standard analgesic protocol (APAP; n=71). The primary outcome was the maximum value of postoperative pain the patients reported on a numerical rating scale (NRS) during the first 24 h post-surgery. A univariate analysis and multivariate analyses adjusted for age, sex, the stage of hip osteoarthritis, preoperative pain, and surgical time showed that the maximum postoperative pain NRS scores during the first 24 h after surgery was significantly lower when the APAP protocol was used. The addition of IV APAP to the current standard multimodal analgesia protocol for Japanese patients who have undergone a THA may decrease the patients’ postoperative pain.
Keywords intravenous acetaminophen postoperative pain total hip arthroplasty osteoarthritis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 14
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820049
JaLCDOI 10.18926/AMO/56452
FullText URL 73_1_1.pdf
Author Morizane, Shin|
Abstract Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD.
Keywords atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 6
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820048
Title Alternative Discovery Program for Global Learners at Okayama University and IB Education: Reflections on My University Experiences in Japan and the United States of America
FullText URL 2017_001_010_017.pdf
Author Chung, Haeng-ja|
Keywords 日米比較 文化人類学 振り返り Discovery Program for Global Learners at Okayama University グローバル・ディスカバリー・プログラム 国際バカロレア IB
Note 寄稿論文|
Published Date 2017-12
Publication Title 国際バカロレア教育研究
Issue issue1
Publisher 日本国際バカロレア教育学会
Start Page 10
End Page 17
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
File Version publisher
FullText URL K0005295_other1.pdf
Author Onoda, Satoshi| Kimata, Yoshihiro| Matsumoto, Kumiko|
Keywords anastmosis style patency rate rat animal model lymphaticovenular anastomosis
Note 学位審査副論文|
Published Date 2016-03
Publication Title Annals of Plastic Surgery
Volume volume76
Issue issue3
Publisher Little Brown
Start Page 332
End Page 335
ISSN 0148-7043
NCID AA00533030
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26207544
DOI 10.1097/SAP.0000000000000571
Web of Science KeyUT 000370489200017
Related Url https://doi.org/10.1097/SAP.0000000000000571 http://ousar.lib.okayama-u.ac.jp/ja/54278
JaLCDOI 10.18926/CTED/54938
Title Alternative A Comparison between Prefectures of Result of National Achievement Test in Japan Ⅱ
FullText URL cted_007_127_136.pdf
Author Ojima, Taku|
Abstract 本稿は、2016(平成28)年に文部科学省が実施した「全国学力・学習状況調査」(メインタイトルを含め、以下本稿では、全国学力テストと略記)の結果のうち、テスト受験者の解答した児童質問紙および教員(多くの場合は管理職)が解答した学校質問紙の結果を検討し、学力向上を目指す取組の評価のもととなるデータの整理を主な目的としている。具体的には、􀀔􀀓 年間の学力調査において結果が常に上位を占める秋田県の結果を、学力向上を中心的な行政課題と位置づけてきた岡山県の結果と比較した。この結果、7年前に拙論で指摘された課題と全国的な分析および教科外の取組といった三つの範疇に属する項目において、二つの県では顕著な違いが見られた。
Keywords 秋田県 (Akita Prefecture) 岡山県 (Okayama Prefecture) 全国学力・学習状況調査 (National Assessment of Academic Ability)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2017-03-27
Volume volume7
Start Page 127
End Page 136
ISSN 2186-1323
Related Url http://ousar.lib.okayama-u.ac.jp/ja/48209
language Japanese
Copyright Holders Copyright © 2017 岡山大学教師教育開発センター
File Version publisher
JaLCDOI 10.18926/CTED/54926
Title Alternative How Can We Practice Life-Education as Moral Education in Junior High School?(2)
FullText URL cted_007_011_020.pdf
Author Watanabe, Michiru| Kokayashi, Mariko|
Abstract  阪神・淡路大震災と東日本大震災では,大人だけでなく,多くの子どもたちが犠牲となった。改めて「命の教育」の重要性が指摘されている。また,青少年,特に中学生による殺傷事件やいじめによる自殺も後を絶たない現状にある。一方,2019(平成31)年度から中学校の「道徳の時間」は「特別の教科􀀃 道徳」という名称の教科となる。その理由は様々であるが,教育再生実行会議の第一次提言によれば,同会議が教科化提言に踏み切った直接の要因は,いじめ問題への実効性のある道徳教育を求めることにあった。しかし,学校の道徳教育や「命の教育」は役に立たないという指摘もあり,教科となった道徳科における道徳教育は,これまでの諸課題を確実に見直し,確たる実践的基盤を打ち立てなければならない。本稿(2)では,前号の(1)で論じた〈いのち〉とその教育に関する独自の観点によりながら,「〈いのち〉の教育」に取り組む「道徳科の授業」の新しい展開を提案したい。
Keywords ビオスとゾーエー (bios and zoé) 〈いのち〉の教育 (life-education) 発達段階 (development stages) コミュニケーション的行為 (communicative action) 討議 (Diskurs)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2017-03-27
Volume volume7
Start Page 11
End Page 20
ISSN 2186-1323
Related Url http://ousar.lib.okayama-u.ac.jp/ja/54026
language Japanese
Copyright Holders Copyright © 2017 岡山大学教師教育開発センター
File Version publisher
Title Alternative Drug interaction (38. Combination with novel hypnotic drugs : ramelteon and suvorexant)
FullText URL 129_53.pdf
Author Kubo, Kazuko| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 53
End Page 57
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.53
NAID 130005632075
Title Alternative The 2015 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2015 Sunada Prize)
FullText URL 129_1.pdf
Author Ishigami, Shuta|
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 1
End Page 4
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.1161/CIRCRESAHA.116.304671
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.1
NAID 130005632052
FullText URL fulltext.pdf
Author Yoshihara, S.| Fukuda, H.| Tamura, M.| Arisaka, O.| Ikeda, M.| Fukuda, N.| Tsuji, T.| Hasegawa, S.| Kanno, N.| Teraoka, M.| Wakiguchi, H.| Aoki, Y.| Terada, A.| Hasegawa, M.| Manki, A.| Igarashi, H.|
Keywords salmeterol/fluticasone combination asthma infant preschool children nighttime sleep disorder score long-acting beta-agonist inhaled corticosteroid
Published Date 2016-07
Publication Title Drug Research
Volume volume66
Issue issue7
Publisher Georg Thieme
Start Page 371
End Page 376
ISSN 2194-9379
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Georg Thieme Verlag
File Version publisher
PubMed ID 27273710
DOI 10.1055/s-0042-108852
Web of Science KeyUT 000379389100007
Related Url isVersionOf https://doi.org/10.1055/s-0042-108852
Author Kunisue, Mitsuhisa|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Journal Article
Title Alternative The effectiveness of team-based learning (TBL) as a new teaching approach
FullText URL 128_125.pdf
Author Suno, Manabu|
Keywords アクティブラーニング(active learning) チーム基盤型学習(team-based learning) 問題基盤型学習(problem-based learning)
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 125
End Page 128
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.125
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.125
NAID 130005262530
Title Alternative Incisional hernia repair after wide excision of the iliac bone
FullText URL 128_117.pdf
Author Tsukuda, Kazunori| Asano, Hiroaki| Mandai, Yasuhiro| Fujiwara, Toshiyoshi|
Abstract  The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair.
Keywords 腹壁瘢痕ヘルニア(incisional hernia) 腸骨軟骨肉腫(chondrosarcoma of the iliac bone) 腸骨広範囲切除術(wide excision of the iliac bone) プロリーンメッシュ(prolene mesh)
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 117
End Page 120
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.117
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.117
NAID 130005262528
FullText URL K0005301_abstract_review.pdf K0005301_fulltext.pdf K0005301_summary.pdf
Author Gotoda, Tatsuhiro|
Published Date 2016-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5301号
Granted Date 2016-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Title Alternative Mechanosensor
FullText URL 128_61.pdf
Author Takahashi, Ken|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 61
End Page 62
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.61
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.61
NAID 130005149609
Title Alternative Behçetʼs disease complicated by ileocecal and esophageal perforation
FullText URL 128_27.pdf
Author Tsukumo, Yuta| Kawamoto, Kazuyuki| Takagi, Kosei| Chin, Kai| Matsuba, Yuri| Nagahisa, Yoshio| Okabe, Michio| Shirakawa, Yasuhiro| Itoh, Tadashi| Fujiwara, Toshiyoshi|
Abstract  A 36-year-old Japanese man known to have incomplete Behçet’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection.
Keywords ベーチェット病(Behçet’s disease) 食道(esophagus) 回盲部(ileocecal) 穿孔(perforation) 手術(surgery)
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 27
End Page 32
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.27
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.27
NAID 130005149603