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JaLCDOI 10.18926/AMO/67207
FullText URL 78_3_301.pdf
Author Nakazaki, Kiyoshi| Hirai, Satoshi| Hishikawa, Tomohito|
Abstract We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment.
Keywords vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 301
End Page 306
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902220
Web of Science KeyUT 001267340600001
JaLCDOI 10.18926/AMO/67206
FullText URL 78_3_295.pdf
Author Okamoto, Sara| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Kindo, Hiroya| Morita, Tetsuro| Tsuji, Akihiro| Takahashi, Kosuke| Morizane, Yuki|
Abstract A Japanese woman in her 70s was referred to our hospital for the evaluation and treatment of high intraocular pressure (IOP) in her right eye. She had undergone bilateral cataract surgeries and the insertion of hydrophilic acrylic intraocular lenses (IOLs). We performed trabeculotomy and trabeculectomy to lower her right IOP; thereafter, a circular opacity was observed on the right eye’s IOL surface. We removed the right IOL because that eye’s vision had decreased due to IOL opacification. The analysis of the removed IOL revealed that the main opacity component was calcium phosphate. This is the first post-glaucoma-surgery IOL calcification case report.
Keywords intraocular lens IOL IOL calcification hydrophilic acrylic IOL glaucoma surgery
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 295
End Page 300
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902219
Web of Science KeyUT 001267339400001
JaLCDOI 10.18926/AMO/67203
FullText URL 78_3_281.pdf
Author Okada, Kazuhiro| Maki, Yuho| Matsubara, Kei| Hirano, Yutaka| Fujiwara, Toshiya| Matsuura, Motoki|
Abstract A 24-year-old Japanese female with anorexia nervosa presented to our hospital for bilateral pneumothorax, and 12-Fr thoracostomy catheters were inserted into the bilateral pleural cavities. On hospital day 9, a thoracoscopic bullectomy was performed. However, air leakage relapsed on both sides on postoperative day 1. The air leakage on the right side was particularly persistent, and we switched the drainage to a Heimlich valve. Both lungs expanded gradually and the chest tube was removed on postoperative day 19. Passive pleural drainage might be an option for prolonged air leakage after a bullectomy in patients with anorexia nervosa.
Keywords spontaneous pneumothorax anorexia nervosa Heimlich valve
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 281
End Page 284
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902216
Web of Science KeyUT 001267351900001
JaLCDOI 10.18926/AMO/67202
FullText URL 78_3_271.pdf
Author Ye, Mengjiao| Zhang, Renwei|
Abstract We investigated how humidified high-flow nasal cannula oxygen therapy (HFNC) with a pulmonary infection control (PIC) window as a ventilation switching indication in combination with atomizing inhalation of terbutaline affects the lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We examined 140 hospitalized AECOPD patients randomized to control and observation groups. Conventional supportive therapy and invasive mechanical ventilation with tracheal intubation were conducted in both groups, with a PIC window as the indication for ventilation switching. Noninvasive positive pressure ventilation (NIPPV) plus atomizing inhalation of terbutaline was used in the control group. In the observation group, HFNC combined with atomizing inhalation of terbutaline was used. Compared to the control group, after 48-hr treatment and treatment completion, the observation group had significantly increased levels of lung function indicators (maximal voluntary ventilation [MVV] plus forced vital capacity [FVC], p<0.05) and oxygen metabolism indicators (arterial oxygen partial pressure [PaO2], arterial oxygen content [CaO2], and oxygenation index, p<0.05). The comparison of the groups revealed that the levels of airway remodeling indicators (matrix metalloproteinase-2 [MMP-2], tissue inhibitor of metalloproteinase 2 [TIMP-2] plus MMP-9) and inflammatory indicators (interferon gamma [IFN-γ] together with interleukin-17 [IL-17], IL-10 and IL-4) were significantly lower after 48 h of treatment as well as after treatment completion (both p<0.05). These results demonstrate that HFNC with a PIC window as the indication for ventilation switching combined with atomizing inhalation of terbutaline can relieve the disorder of oxygen metabolism and correct airway hyper-reactivity.
Keywords chronic obstructive pulmonary disease inhalation oxygen therapy pulmonary function ventilation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 271
End Page 279
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902215
Web of Science KeyUT 001267351000008
JaLCDOI 10.18926/AMO/67201
FullText URL 78_3_259.pdf
Author Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan|
Abstract The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured.
We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients.
Keywords multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 259
End Page 270
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902214
Web of Science KeyUT 001267351000007
JaLCDOI 10.18926/AMO/67199
FullText URL 78_3_245.pdf
Author Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa|
Abstract Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients.
Keywords knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 245
End Page 250
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902212
Web of Science KeyUT 001267351000005
JaLCDOI 10.18926/AMO/67198
FullText URL 78_3_237.pdf
Author Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi|
Abstract Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period.
Keywords fracture liaison services complications after admission secondary hip fracture mortality
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 237
End Page 243
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902211
Web of Science KeyUT 001267351000004
JaLCDOI 10.18926/AMO/67197
FullText URL 78_3_227.pdf
Author Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki|
Abstract Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
Keywords lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 227
End Page 235
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902210
Web of Science KeyUT 001267351000003
JaLCDOI 10.18926/AMO/67196
FullText URL 78_3_215.pdf
Author Akagawa, Takuya| Fukui, Ryohei| Kida, Katsuhiro| Matsuura, Ryutaro| Shimada, Makoto| Kinoshita, Mitsuhiro| Akagawa, Yoko| Goto, Sachiko|
Abstract We propose a sitting position that achieves both high image quality and a reduced radiation dose in elbow joint imaging by area detector computed tomography (ADCT), and we compared it with the ‘superman’ and supine positions. The volumetric CT dose index (CTDIvol) for the sitting, superman, and supine positions were 2.7, 8.0, and 20.0 mGy and the dose length products (DLPs) were 43.4, 204.7, and 584.8 mGy • cm, respectively. In the task-based transfer function (TTF), the highest value was obtained for the sitting position in both bone and soft tissue images. The noise power spectrum (NPS) of bone images showed that the superman position had the lowest value up to approx. 1.1 cycles/mm or lower, whereas the sitting position had the lowest value when the NPS was greater than approx. 1.1 cycles/mm. The overall image quality in an observer study resulted in the following median Likert scores for Readers 1 and 2: 5.0 and 5.0 for the sitting position, 4.0 and 3.5 for the superman position, and 4.0 and 2.0 for the supine position. These results indicate that our proposed sitting position with ADCT of the elbow joint can provide superior image quality and allow lower radiation doses compared to the superman and supine positions.
Keywords area detector computed tomography elbow joint sitting position dose reduction image quality assessment
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 215
End Page 225
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902209
Web of Science KeyUT 001267351000002
JaLCDOI 10.18926/AMO/67195
FullText URL 78_3_205.pdf
Author Hagiya, Hideharu|
Abstract The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists.
Keywords antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 205
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902208
Web of Science KeyUT 001267351000001
FullText URL fulltext.pdf
Author Mao, Zhiyuan| Li, Xingyue| Li, Zhenhua| Shen, Liangliang| Li, Xiaoyi| Yang, Yanyan| Wang, Wenda| Kuang, Tingyun| Shen, Jian-Ren| Han, Guangye|
Note The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48878-x|
Published Date 2024-05-28
Publication Title Nature Communications
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 4535
ISSN 2041-1723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38806516
DOI 10.1038/s41467-024-48878-x
Web of Science KeyUT 001234660500031
Related Url isVersionOf https://doi.org/10.1038/s41467-024-48878-x
FullText URL fulltext.pdf
Author Sakurada, Takato| Chikada, Yuta| Miyahara, Ryo| Taniguchi, Yosuke|
Keywords 8-oxo-2 '-deoxyguanosine single nucleotide elongation reaction artificial nucleoside triphosphate 2 '-deoxycytidine derivatives
Published Date 2024-05-11
Publication Title Molecules
Volume volume29
Issue issue10
Publisher MDPI
Start Page 2270
ISSN 1420-3049
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 38792131
DOI 10.3390/molecules29102270
Web of Science KeyUT 001231259100001
Related Url isVersionOf https://doi.org/10.3390/molecules29102270
FullText URL fulltext.pdf
Author Miyoshi, Shin-Ichi| Kurata, Megumi| Hirose, Riho| Yoshikawa, Masaya| Liang, Yong| Yamagishi, Yosuke| Mizuno, Tamaki|
Keywords Vibrio cholerae Vibrio vulnificus genotype LAMP water temperature
Published Date 2024-04-27
Publication Title Microorganisms
Volume volume12
Issue issue5
Publisher MDPI
Start Page 877
ISSN 2076-2607
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 38792707
DOI 10.3390/microorganisms12050877
Web of Science KeyUT 001231571500001
Related Url isVersionOf https://doi.org/10.3390/microorganisms12050877
FullText URL O0004558_abstract_review.pdf O0004558_summary.pdf
Author LUONG QUANG TUONG|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 乙第4558号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Environmental Science
Grantor 岡山大学
language English
FullText URL K00007079_abstract_review.pdf K00007079_fulltext.pdf K00007079_summary.pdf
Author SHIMADA, Makoto|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7079号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language English
Copyright Holders © The Author(s) 2023.
FullText URL K00007078_abstract_review.pdf K00007078_fulltext.pdf K00007078_summary.pdf
Author AKAGAWA, Takuya|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7078号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
FullText URL K0007037_abstract_review.pdf K0007037_fulltext.pdf
Author TANIGUCHI, Rikako|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7037号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Pharmaceutical Sciences
Grantor 岡山大学
language Japanese
FullText URL K0007036_abstract_review.pdf K0007036_fulltext.pdf K0007036_summary.pdf
Author Jiao, YuYang|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7036号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
Copyright Holders © 2023 by the authors.
FullText URL K0007033_abstract_review.pdf K0007033_fulltext.pdf K0007033_summary.pdf
Author MATSUOKA, Daiki|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7033号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
Copyright Holders © 2022 Naka, Matsuoka, Goto, Misaki, Nagasawa, Ito, Nomura, Nakano and Matsumoto-Nakano.
FullText URL K0007014_abstract_review.pdf K0007014_fulltext.pdf K0007014_summary.pdf
Author FUKUMURA, Yuka|
Published Date 2024-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7014号
Granted Date 2024-03-25
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
Copyright Holders © 2023 by the authors.