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ID 31066
JaLCDOI
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Author
Haraoka, Shoichi
Saito, Daiji
Miyasaka, Minoru
Kawasaki, Tomoko
Yoshioka, Nobuhiko
Ikenaga, Toyotake
Okazaki, Satoru
Abstract

The case of a patient with repeated attacks of collapse induced by sublingual isosorbide dinitrate is reported. The patient was an 81 year-old female who was admitted to Yura Hospital because of attacks of precordial pain. Several minutes after the sublingual administration of isosorbide dinitrate (10 mg) for an anginal attack, she developed a sensation of general weakness, and thereafter because unconscious. Arterial blood pressure fell and became unmeasurable. Electrocardiograms recorded during the syncopal attack showed sinus tachycardia and significant elevation of ST-segment in right precordial leads. In response to a drip infusion of noradrenaline, arterial blood pressure returned to normal with recovery of consciousness. Two similar syncopal attacks induced by sublingual isosorbide dinitrate occurred in the next three days. These attacks were not due to augmentation of the vagal reflex. Decrease of venous return probably was the primary etiological factor.

Keywords
isosorbide dinitrate
syncopal attack hypotension
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1978-10
Volume
volume32
Issue
issue5
Publisher
Okayama University Medical School
Start Page
369
End Page
378
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
NAID