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Multifunctional Bone Morphogenetic Protein System in Endocrinology

JaLCDOI	10.18926/AMO/49665
FullText URL	67_2_75.pdf
Author	Otsuka, Fumio\|
Abstract	New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushingʼs disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.
Keywords	bone morphogenetic protein folliculogenesis pituitary adenoma steroidogenesis transforming growth factor
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2013-04
Volume	volume67
Issue	issue2
Publisher	Okayama University Medical School
Start Page	75
End Page	86
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2013 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	23603923
Web of Science KeyUT	000317801700001

Studies on Bacterial Catalase.

Author	Itano, Arao\| Arakawa, Satiyo\|
Published Date	1928-01-26
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue5
Content Type	Departmental Bulletin Paper

Some Scientific Consideration on the Itano Process of Composting.* I. General Description, Nature of Fermentation and Sanitary Significance.

Author	Itano, Arao\| Arakawa, Satiyo\|
Published Date	1927-10-26
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue5
Content Type	Departmental Bulletin Paper

Über die in der Landwirtschaft Japans gebrauchten Samen. (Siebente Mitteilung.)

Author	Kondō, Mantarō\|
Published Date	1927-12-01
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue5
Content Type	Departmental Bulletin Paper

Über die in der Landwirtschaft Japans gebrauchten Samen. (Sechste Mitteilung.)

Author	Kondō, Mantarō\|
Published Date	1927-07-25
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue4
Content Type	Departmental Bulletin Paper

Spontane Entstehung einer missgestalteten Reispflanze ”Magatamaine“

Author	Kondō, Mantarō\| Fujimoto, Sumita\|
Published Date	1927-05-20
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue4
Content Type	Departmental Bulletin Paper

Untersuchungen der verschiedenen Reiskörner geringerer Qualität. I. Die braun gefärbten enthülsten Reiskörner ”Tschamai“*.

Author	Kondō, Mantarō\| Okamura, Tamotsu\|
Published Date	1927-01-06
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue4
Content Type	Departmental Bulletin Paper

Studies on the Toxicity of Lime-Sulphur Mixture.&dagger;

Author	Harukawa, Chukichi\|
Published Date	1927-02-28
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue4
Content Type	Departmental Bulletin Paper

Temperature Relations to the Growth of Graminicolous Species of Helminthosporium: I. Effect of Temperature on the Vegetative and Reproductive Growth of Helminthosporium turcicum Passer. and Helminthosporium Maydis Nisikado et Miyake.&dagger;

Author	Nisikado, Yosikazu\|
Published Date	1927-02-25
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Investigation on the Biilmann's Quinhydrone Electrode. III. (Further studies on the electrode and agar bridge.)

Author	Itano, A.\| Arakawa, S.\| Hosoda, K.\|
Published Date	1927-02-20
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Studies on the Carbon-Nitrogen Ratio and Microbiological Investigation of the Soil in Rice-field. I. The Carbon-Nitrogen Ratio.

Author	Itano, Arao\| Arakawa, Satiyo\|
Published Date	1927-01-10
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Kreuzungsuntersuchungen an Reispflanzen. II. Ueber die zweite (S-M-) Koppelungsgruppe mit besonderer Berücksichtigung ihrer korrelativen Beziehung zur Blütezeit.(Vorläuflge Mitteilung.)

Author	Yamaguti, Yasuke\|
Published Date	1927-01-15
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Untersuchungen über die Weiss-Gestreifte Reispflanze (Shimaine).

Author	Kondō, Mantarō\| Takeda, Motoharu\| Fujimoto, Sumita\|
Published Date	1927-02-05
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Über die Ergebnisse der Pedigree-Zucht der Semisterilen Reispflanzen.

Author	Kondō, Mantarō\|
Published Date	1927-01-16
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue3
Content Type	Departmental Bulletin Paper

Outline of The &Omacr;hara Institute for Agricultural Research.

Published Date	1926
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

Studies on two Helminthosporium Diseases of Maize，Caused by Helminthosporium turcicum Passerini and Ophiobolus heterostrophus Drechsler (-Helm. Maydis Nisikado et Miyake).

Author	Nisikado, Yosikazu\| Miyake, Chuichi\|
Published Date	1926-08-25
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

Studies on the cellulose.* (Publlation on cellulose No. I.)

Author	Itano, Arao\|
Published Date	1926-08-13
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

Table for PH Values Corresponding to Electromotive Forces determined in Quinhydrone Electrode Measurements. II.*

Author	Itano, A.\| Hosoda, K.\|
Published Date	1926-08-13
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

Investigation on the Biilman's* Quinhydrone Electrode. I.

Author	Itano, A.\| Hosoda, K.\|
Published Date	1926-08-13
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

Soil Microorganismus and Activators.

Author	Itano, Arao\|
Published Date	1926-08-13
Publication Title	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
Volume	volume3
Issue	issue2
Content Type	Departmental Bulletin Paper

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