result 5751 件
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2013 Sunada Prize) |
|---|---|
| FullText URL | 126_95.pdf |
| Author | Nakatsuka, Atsuko| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 95 |
| End Page | 98 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.95 |
| NAID | 130004685276 |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in Cancer Research (2013 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 126_93.pdf |
| Author | Ohara, Toshiaki| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 93 |
| End Page | 94 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.93 |
| NAID | 120005468246 |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in Cancer Research (2013 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 126_87.pdf |
| Author | Miyahara, Koji| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 87 |
| End Page | 88 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.87 |
| NAID | 120005468244 |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize) |
|---|---|
| FullText URL | 126_83.pdf |
| Author | Murata, Hitoshi| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 83 |
| End Page | 86 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.83 |
| NAID | 130004685272 |
| JaLCDOI | 10.18926/AMO/52659 |
|---|---|
| FullText URL | 68_3_177.pdf |
| Author | Mizuno, Shoma| Ota, Seisuke| Tanaka, Takehiro| Shiomi, Kohei| Matsumura, Tadashi| Kishimoto, Nobuyasu| |
| Abstract | Primary tracheal malignant lymphoma is a rare disease;only 30 cases have been reported to date. A 73-year-old Japanese man with a history of asbestos exposure was undergoing biannual chest computed tomography (CT) twice a year as a routine procedure for those previously exposed to asbestos. He had been smoking since the age of 32. In September 2010, chest CT during this regular checkup revealed a polypoid lesion in his trachea and pleural plaques, which were suspected to be caused by asbestos. Bronchoscopy performed in October revealed a polypoid lesion with granules and nodules in the trachea. A diagnosis of non-Hodgkin lymphoma (NHL) and extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was confirmed by histological analysis of the biopsy specimens. To our knowledge, this is the first case of primary tracheal lymphoma associated with a history of asbestos exposure. Several reports have documented no correlation between asbestos and malignant lymphoma. In addition, the correlation between smoking and NHL is weak. Although we cannot exclude the possibility of a simple coincidence of asbestos, smoking, and tracheal lymphoma, this case suggests that asbestos and smoking might have multiplicative effects in the development or progression of tracheal lymphoma. |
| Keywords | bronchus-associated lymphoid tissue tracheal lymphoma regular checkup asbestos smoking |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 181 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942797 |
| Web of Science KeyUT | 000337655600008 |
| JaLCDOI | 10.18926/AMO/52657 |
|---|---|
| FullText URL | 68_3_163.pdf |
| Author | Tate, Genshu| Kishimoto, Koji| Mitsuya, Toshiyuki| |
| Abstract | The aim of the present study is to address whether the molecular pathogenesis is identical among multiple basal cell carcinomas (BCCs) present in the same nevoid basal cell carcinoma syndrome (NBCCS) patient. Patient 1 is a 61-year-old (yo) Japanese female whose clinical characteristics and findings of a genetic analysis of PTCH1 have been previously described. Patient 2 is patient 1ʼs 64-yo sister who also suffered from NBCCS with a single base deletion at nucleotide 2613 in exon 16 (c.2613delC) in one PTCH1 allele. Thirteen and 3 independent specimens of BCC were applied for a molecular analysis of loss of heterozygosity (LOH) in PTCH1 in patients 1 and 2, respectively. Of particular note is that all BCC specimens examined showed a loss of the wild-type allele of exon 16 in PTCH1, thus indicating that LOH results in the biallelic disruption of PTCH1 in multiple BCCs that develop in an age- and location-independent manner in the same patient. These results indicate that the germline single base deletion of PTCH1 (c.2613 delC) is a first hit and the LOH of the wild-type allele is a second hit, implying that all 16 BCCs detected in these NBCCS sisters fit the standard two-hit model. |
| Keywords | biallelic disruption hedgehog nevoid basal cell carcinoma syndrome Patched 1 two-hit model |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-06 |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 163 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24942795 |
| Web of Science KeyUT | 000337655600006 |
| FullText URL | K0004978_abstract_review.pdf K0004978_fulltext.pdf |
|---|---|
| Author | Yoshioka, Shin| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4978号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004911_abstract_review.pdf K0004911_fulltext.pdf |
|---|---|
| Author | Terasaka, Tomohiro| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4911号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Fujiwara, Tomohiro| |
|---|---|
| Published Date | 2014-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004893_abstract_review.pdf K0004893_fulltext.pdf |
|---|---|
| Author | Yano, Shuya| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4893号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004889_abstract_review.pdf K0004889_fulltext.pdf |
|---|---|
| Author | Takahara, Masahiro| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4889号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Narita, Yuichi| Kajari Karmakar| Sébastien Ducret| Filippo M. Rijli| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume30 |
| Content Type | Others |
| JaLCDOI | 10.18926/bgeou/52429 |
|---|---|
| Title Alternative | Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders |
| FullText URL | 110_0029_0034.pdf |
| Author | Sanada, Satoshi| Asano, Takashi| Oka, Eiji| Kawahara, Michiko| Sakae, Katsumi| Hiraki, Norio| Ohtahara, Shunsuke| |
| Abstract | Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA)，creatine (Cr) and choline (Ch). Hence，clinical applications of this method for neuropediatric diseases can be expected. However，regarding neuronal migration disorders，there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders，ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr，Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ～ 3 × 3 × 5cm3 was chosen in the area including lesions，and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41，1.95，2.27 and 1.71 in cases with heterotopic gray matter，0.99 in one case with polymicrogyria，an d 1.30 in one case with hemimegalencephaly，contrasted with a contralataral area without lesions: 1.89， 2.89，2.87，2.55，3.26，2.03，respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population，or reduced metabolism in the lesions. |
| Keywords | MR spectroscopy migration disorder heterotopic gray matter polymicrogyria hemimegalencephaly |
| Publication Title | 岡山大学教育学部研究集録 |
| Published Date | 1999-03-15 |
| Volume | volume110 |
| Start Page | 29 |
| End Page | 34 |
| ISSN | 0471-4008 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005425646 |
| Author | Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | International Orthopaedics |
| Volume | volume37 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho| |
|---|---|
| Published Date | 2013-10 |
| Publication Title | International Journal of Molecular Medicine |
| Volume | volume32 |
| Issue | issue4 |
| Content Type | Journal Article |
| FullText URL | Talanta_122_240–245.pdf |
|---|---|
| Author | Higashidani, Naoki| Kaneta, Takashi| Takeyasu, Nobuyuki| Motomizu, Shoji| Okibe, Naoko| Sasaki, Keiko| |
| Keywords | Thermoacidophilic iron-oxidizing archaeon Acidianus brierleyi Arsenic Speciation Inductively coupled plasma–optical emission spectroscopy Flow injection pretreatment |
| Published Date | 2014-05 |
| Publication Title | Talanta |
| Volume | volume122 |
| Publisher | Elsevier |
| Start Page | 240 |
| End Page | 245 |
| ISSN | 00399140 |
| NCID | AA00856594 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2014 Elsevier B.V. All rights reserved |
| File Version | author |
| PubMed ID | 24720990 |
| DOI | 10.1016/j.talanta.2014.01.057 |
| Web of Science KeyUT | 000335636700037 |
| Related Url | isVersionOf https://doi.org/10.1016/j.talanta.2014.01.057 |
| JaLCDOI | 10.18926/AMO/52404 |
|---|---|
| FullText URL | 68_2_79.pdf |
| Author | Mu-Mu-Shwe| Harano, Teruo| Okada, Shigeru| Aye-Aye-Win| Khin-Saw-Aye| Hlaing-Myat-Thu| Mo-Mo-Win| Khin-Khin-Oo| Myo-Khin| |
| Abstract | This study aimed to determine the prevalence of normal and abnormal cervical cytology in women who attended the cervical cancer screening clinic of the Department of Medical Research in Lower Myanmar, and to determine the proportion of high-risk (HR) human papillomavirus (HPV) infection and HPV genotypes in women with normal and abnormal cervical cytology. A total of 1,771 women were screened from 2010 to 2011. Among them, 762 women (43.0%) had a normal smear, and 866 (48.9%) and 87 (4.9%) were diagnosed with inflammatory smears and atypical squamous cells of undetermined significance (ASCUS), respectively. Diagnoses of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) numbered 42 (2.3%) and 11 (0.6%) respectively. Three cases of squamous cell carcinoma (SCC) (0.2%) were detected. Cervical swabs were collected from 96 women with abnormal cervical cytology and 20 with normal cytology. HR-HPV DNA testing was performed by polymerase chain reaction (PCR) with pU1M/pU2R primers. HR-HPV were identified in 35.5% (22/62) of inflammatory smears, 60% (6/10) of ASCUS, 86.7% (13/15) of LSIL, 50% (3/6) of HSIL, 100% (3/3) of SCC and 5% (1/20) of normal cytology. In PCR-positive cases, HPV genotyping was analyzed by the cleaved amplification polymorphism method. The most prevalent HPV genotypes were HPV-16 (60.4%) followed by HPV-31 (14.6%), HPV-18 (12.5%) and HPV-58 (12.5%). Women with abnormal cervical cytology were 10 times more likely to be HR-HPV positive than those with normal cytology (p＝0.0001). This study suggests that the implementation of a cervical cytology screening program and routine vaccination against HPV in preadolescent and adolescent groups are needed to reduce the burden of HPV-associated cervical cancer. |
| Keywords | human papillomavirus cervical neoplasia genotyping Myanmar |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 87 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743783 |
| Web of Science KeyUT | 000334652700003 |
| Author | Masumoto, Toshio| Suzuki, Koichiro| Ohmori, Iori| Michiue, Hiroyuki| Tomizawa, Kazuhito| Fujimura, Atsushi| Nishiki, Tei-ichi| Matsui, Hideki| |
|---|---|
| Published Date | 2012-01 |
| Publication Title | Molecular and Cellular Neuroscience |
| Volume | volume49 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kurimoto, Etsuko| Miyahara, Nobuaki| Kanehiro, Arihiko| Waseda, Koichi| Taniguchi, Akihiko| Ikeda, Genyo| Koga, Hikari| Nishimori, Hisakazu| Tanimoto, Yasushi| Kataoka, Mikio| Iwakura, Yoichiro| Gelfand, Erwin W.| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2013-01-20 |
| Publication Title | Respiratory Research |
| Volume | volume14 |
| Content Type | Journal Article |
| Author | Yoneda, Yasushi| Ito, Sachio| Kunisada, Toshiyuki| Morimoto, Yuki| Kanzaki, Hirotaka| Yoshida, Aki| Shimizu, Kenji| Ozaki, Toshifumi| Ouchida, Mamoru| |
|---|---|
| Published Date | 2013-10-09 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
