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Author Omichi, Ryotaro| Yoshimura, Hidekane| Shibata, Seiji B.| Vandenberghe, Luk H.| Smith, Richard J.H.|
Keywords AAV2 adeno-associated virus deafness dual vectors gene therapy hair cells hearing loss injection tropism viral vectors
Published Date 2020-05-13
Publication Title Molecular Therapy - Methods & Clinical Development
Volume volume17
Publisher Cell Press
Start Page 1167
End Page 1177
ISSN 23290501
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32518805
DOI 10.1016/j.omtm.2020.05.007
Web of Science KeyUT 000540906400104
Related Url isVersionOf https://doi.org/10.1016/j.omtm.2020.05.007
FullText URL fulltext.pdf
Author Morita, Daichi| Takahashi, Eizo| Morita, Masatomo| Ohnishi, Makoto| Mizuno, Tamaki| Miyoshi, Shin‐ichi| Dutta, Devarati| Ramamurthy, Thandavarayan| Chowdhury, Goutam| Mukhopadhyay, Asish K.| Okamoto, Keinosuke|
Keywords antibiotic resistance diarrhea genome sequence genomic island integron Vibrio cholerae
Note This is the peer reviewed version of the following article: Daichi Morita et. al. Genomic characterization of antibiotic resistance‐encoding genes in clinical isolates of Vibrio cholerae non‐O1/non‐O139 strains from Kolkata, India: generation of novel types of genomic islands containing plural antibiotic resistance genes. Microbiology and Immunology 64(6) 435-444 (2020), which has been published in final form at https://doi.org/10.1111/1348-0421.12790. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.|
Published Date 2020-03-28
Publication Title Microbiology and Immunology
Volume volume64
Issue issue6
Publisher Wiley
Start Page 435
End Page 444
ISSN 03855600
NCID AA00738350
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32222116
DOI 10.1111/1348-0421.12790
Web of Science KeyUT 000527073000001
Related Url isVersonOf https://doi.org/10.1111/1348-0421.12790
FullText URL MGM_fulltext.pdf MGM_Fig1.tif MGM_Fig2.tif MGM_Fig3.tiff MGM_SuppleFig1.tif MGM_SuppleFig2.tif
Author Akiyama, Tomoyuki| Kubota, Takuo| Ozono, Keiichi| Michigami, Toshimi| Kobayashi, Daisuke| Takeyari, Shinji| Sugiyama, Yuichiro| Noda, Masahiro| Harada, Daisuke| Namba, Noriyuki| Suzuki, Atsushi| Utoyama, Maiko| Kitanaka, Sachiko| Uematsu, Mitsugu| Mitani, Yusuke| Matsunami, Kunihiro| Takishima, Shigeru| Ogawa, Erika| Kobayashi, Katsuhiro|
Keywords Asfotase alfa Liquid chromatography Vitamin B6 Diagnostic marker Therapeutic monitoring
Published Date 2018-07-17
Publication Title Molecular Genetics and Metabolism
Volume volume125
Issue issue1-2
Publisher Elsevier
Start Page 174
End Page 180
ISSN 10967192
NCID AA11158931
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30049651
DOI 10.1016/j.ymgme.2018.07.006
Web of Science KeyUT 000447682900022
Related Url isVersionOf https://doi.org/10.1016/j.ymgme.2018.07.006
JaLCDOI 10.18926/AMO/58276
FullText URL 74_2_165.pdf
Author Umemura, Hiroshi| Miura, Katsuhiro | Naruse, Hiromu| Hatta, Yoshihiro| Takei, Masami| Nakayama, Tomohiro|
Abstract Hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu disease) is an autosomal dominant genetic disorder that causes frequent epistaxis, mucocutaneous telangiectasia, and visceral arteriovenous malformations. Four genes (ENG, ACVRL1, SMAD4, and GDF2) have been identified as pathogenic in HHT. We describe the case of a 50-year-old Japanese man highly suspected of having HHT due to recurrent epistaxis, mucocutaneous telangiectasia, and a family history. Genomic analysis revealed a novel missense mutation of c.100T>A, p.Cys34Ser in the patient’s ACVRL1 gene. We used 6 freeware programs to perform an in silico analysis of this mutation. The results demonstrated the mutation’s high pathogenicity.
Keywords ACVRL1 hereditary hemorrhagic telangiectasia in silico analysis missense mutation Osler-Weber- Rendu disease
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 165
End Page 169
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341592
Web of Science KeyUT 000528278500011
NAID 120006839455
FullText URL fulltext.pdf
Author Kin, Kyohei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao|
Keywords animal model alpha-synuclein DJ-1 neurotoxin Parkin Parkinson's disease pesticide PINK1 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine
Published Date 2019-10-30
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue21
Publisher MDPI
Start Page E5402
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31671557
DOI 10.3390/ijms20215402
Web of Science KeyUT 000498946100160
Related Url isVersionOf https://doi.org/10.3390/ijms20215402
FullText URL NCN7_5_288.pdf Fig.pdf
Author Nakano, Yumiko| Tsunoda, Keiichiro| Yamashita, Toru| Mitsui, Jun| Sato, Kota| Takemoto, Mami| Hishikawa, Nozomi| Ohta, Yasuyuki| Toda, Tatsushi| Tsuji, Shoji| Abe, Koji|
Keywords anti-cholinesterase drug the CHRNE gene congenital myasthenic syndrome late presentation mimicking seronegative myasthenia gravis
Note "This is the peer reviewed version of the following article: Yumiko Nakano et. al. Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis. Neurology and Clinical Neuroscience (2019) 7(5) 288-290, which has been published in final form at https://doi.org/10.1111/ncn3.12317. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."|
Published Date 2019-06-29
Publication Title Neurology and Clinical Neuroscience
Volume volume7
Issue issue5
Publisher Wiley
Start Page 288
End Page 290
ISSN 2049-4173
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1111/ncn3.12317
Web of Science KeyUT 000476042100001
Related Url isVersionOf https://doi.org/10.1111/ncn3.12317
FullText URL fulltext.pdf
Author Iwata, Yasunori| Satou, Kenji| Furuichi, Kengo| Yoneda, Ikuko| Matsumura, Takuhiro| Yutani, Masahiro| Fujinaga, Yukako| Hase, Atsushi| Morita, Hidetoshi| Ohta, Toshiko| Senda, Yasuko| Sakai-Takemori, Yukiko| Wada, Taizo| Fujita, Shinichi| Miyake, Taito| Yasuda, Haruka| Sakai, Norihiko| Kitajima, Shinji| Toyama, Tadashi| Shinozaki, Yasuyuki| Sagara, Akihiro| Miyagawa, Taro| Hara, Akinori| Shimizu, Miho| Kamikawa, Yasutaka| Ikeo, Kazuho| Shichino, Shigeyuki| Ueha, Satoshi| Nakajima, Takuya| Matsushima, Kouji| Kaneko, Shuichi| Wada, Takashi|
Keywords Bloodstream infection Cna MRSA Whole genome sequencing
Published Date 2019-11-15
Publication Title International Journal of Infectious Diseases
Volume volume91
Publisher Elsevier
Start Page 22
End Page 31
ISSN 12019712
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
File Version publisher
PubMed ID 31740408
DOI 10.1016/j.ijid.2019.11.003
Web of Science KeyUT 000510867100004
Related Url isVersionOf https://doi.org/10.1016/j.ijid.2019.11.003
FullText URL fulltext.pdf
Author Yokoi, Katsuyuki| Nakajima, Yoko| Shinkai, Yasuko| Sano, Yoshimi| Imamura, Mototaka| Akiyama, Tomoyuki| Yoshikawa, Tetsushi| Ito, Tetsuya| Kurahashi, Hiroki|
Keywords ALPL Dominant-negative mutations Hypophosphatasia Premature loss of deciduous
Published Date 2019-12-31
Publication Title Molecular Genetics and Metabolism Reports
Volume volume21
Publisher Elsevier
Start Page 100515
ISSN 22144269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 31641588
DOI 10.1016/j.ymgmr.2019.100515
Web of Science KeyUT 000500718300013
Related Url isVersionOf https://doi.org/10.1016/j.ymgmr.2019.100515
FullText URL fulltext.pdf
Author Noguchi, Hirofumi| Miyagi-Shiohira, Chika| Nakashima, Yoshiki| Kinjo, Takao| Kobayashi, Naoya| Saitoh, Issei| Watanabe, Masami| Shapiro, A. M. James| Kin, Tatsuya|
Keywords induced tissue-specific progenitor cells iTP induced tissue-specific stem cells iTS induced pluripotent stem cells iPSCs reprogramming factors pancreas
Published Date 2019-06-14
Publication Title Molecular Therapy - Methods and Clinical Development
Volume volume13
Publisher Cell Press
Start Page 243
End Page 252
ISSN 2329-0501
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
PubMed ID 30828587
DOI 10.1016/j.omtm.2019.01.011
Web of Science KeyUT 000471284200022
Related Url isVersionOf https://doi.org/10.1016/j.omtm.2019.01.011
FullText URL NeurobiolDis_50_209.pdf
Author Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Mori, Akiko| Michiue, Hiroyuki| Nishiki, Teiichi| Ohtsuka, Yoko| Matsui, Hideki|
Note CACNA1A variants contribute to severity of seizures in Dravet syndrome|
Published Date 2013-02
Publication Title Neurobiology of disease
Volume volume50
Publisher Academic Press
Start Page 209
End Page 217
ISSN 09699961
NCID AA11645502
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 23103419
DOI 10.1016/j.nbd.2012.10.016
Web of Science KeyUT 000313758100023
Related Url isVersionOf https://doi.org/10.1016/j.nbd.2012.10.016
JaLCDOI 10.18926/AMO/56940
FullText URL 73_4_367.pdf
Author Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Abstract Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
Keywords autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 367
End Page 372
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56933
FullText URL 73_4_315.pdf
Author Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya|
Abstract The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
Keywords periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 315
End Page 323
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439954
JaLCDOI 10.18926/AMO/56930
FullText URL 73_4_285.pdf
Author Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Abstract Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
Keywords glioma cytoskeletons invasion microtubules
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 285
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439951
JaLCDOI 10.18926/AMO/56872
FullText URL 73_3_273.pdf
Author Hayata, Kei| Masuyama, Hisashi| Eto, Eriko| Mitsui, Takashi| Tamada, Shoko| Eguchi, Takeshi| Maki, Jota| Tani, Kazumasa| Ohira, Akiko| Washio, Yosuke| Yoshimoto, Junko| Hasegawa, Kosei|
Abstract Nager syndrome is a rare disease involving severe micrognathia and upper limb shortening. In this report, we describe a case in which micrognathia of the fetus was suspected based on the observation of upper limb shortening during detailed B mode and 3D/4D ultrasonographic observation, and combined fetal MRI and 3D-CT led to a prenatal diagnosis of Nager syndrome. Upon birth, because severe micrognathia caused airway obstruction and made it difficult to spread the larynx for intubation, effective ventilation could not be carried out and a tracheostomy was necessary. Since a differential diagnosis of Nager syndrome can be made based on the fact that micrognathia typically co-occurs with upper limb shortening, it is possible to diagnose the disease before birth and prepare for life-saving measures accordingly.
Keywords Nager syndrome acrofacial dysostosis micrognathia jaw index SF3B4
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-06
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235977
JaLCDOI 10.18926/AMO/56870
FullText URL 73_3_263.pdf
Author Shimoyama, Yuichiro| Umegaki, Osamu| Ooi, Yukimasa| Shigemoto, Sho| Agui, Tomoyuki| Kadono, Noriko| Minami, Toshiaki|
Abstract A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and was diagnosed with adrenal insufficiency accompanied by septic shock. He died of multiple organ failure 29 h post-admission to our ICU.
Keywords fulminant type 1 diabetes mellitus human immunodeficiency virus cytomegalovirus hypoglycemia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-06
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 263
End Page 267
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235975
JaLCDOI 10.18926/AMO/56869
FullText URL 73_3_255.pdf
Author Seki, Daisuke| Takeshita, Nobuo| Seiryu, Masahiro| Deguchi, Toru| Takano-Yamamoto, Teruko|
Abstract Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population.
Keywords Axenfeld-Rieger syndrome external apical root resorption miniscrew implant anterior open bite
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-06
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 262
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235974
FullText URL J_ClinMicrobiol_51_3_1040.pdf
Author Naha, A.| Chowdhury, G.| Ghosh-Banerjee, J.| Senoh, M.| Takahashi, T.| Ley, B.| Thriemer, K.| Deen, J.| Seidlein, L. V.| Ali, S. M.| Khatib, A.| Ramamurthy, T.| Nandy, R. K.| Nair, G. B.| Takeda, Y.| Mukhopadhyay, A. K.|
Keywords Vibrio cholerae ctxB Cholera PFGE
Note This is an Accepted Manuscript of an article published by American Society for Microbiology|
Published Date 2013-03
Publication Title Journal of Clinical Microbiology
Volume volume51
Issue issue3
Publisher American Society for Microbiology
Start Page 1040
End Page 1045
ISSN 00951137
NCID AA00695531
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 23325815
DOI 10.1128/JCM.03162-12
Web of Science KeyUT 000315121700055
Related Url isVersionOf https://doi.org/10.1128/JCM.03162-12
FullText URL Nucleic _Acids_Res_44_12_5658.pdf
Author Bhupesh Kumar Thakur| Dasgupta, Nirmalya| Ta, Atri| Das, Santasabuj|
Published Date 2016-04-07
Publication Title Nucleic Acids Research
Volume volume44
Issue issue12
Publisher Oxford University Press
Start Page 5658
End Page 5672
ISSN 03051048
NCID AA00760269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 27060138
DOI 10.1093/nar/gkw189
Web of Science KeyUT 000381210900019
Related Url isVersionOf https://doi.org/10.1093/nar/gkw189
JaLCDOI 10.18926/AMO/56655
FullText URL 73_2_181.pdf
Author Okamura, Tomoka| Washio, Yousuke| Yoshimoto, Junko| Tani, Kazumasa| Tsukahara, Hirokazu| Shimada, Akira|
Abstract Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.
Keywords cytarabine Down syndrome exchange transfusion hydrops fetalis transient abnormal myelopoiesis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 181
End Page 188
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015754
FullText URL K0005801_abstract_review.pdf K0005801_fulltext.pdf K0005801_summary.pdf
Author Haruma, Tomoko|
Published Date 2018-09-27
Content Type Thesis or Dissertation
Grant Number 甲第5801号
Granted Date 2018-09-27
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English