Conditions

close

result 1021 件

JaLCDOI 10.18926/AMO/66670
FullText URL 78_1_047.pdf
Author Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)|
Abstract Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
Keywords metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 47
End Page 52
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419314
Web of Science KeyUT 001203658200005
JaLCDOI 10.18926/AMO/66668
FullText URL 78_1_029.pdf
Author Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao|
Abstract This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD.
Keywords methotrexate lymphoproliferative disorder computed tomography necrosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 36
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419312
Web of Science KeyUT 001203658200001
JaLCDOI 10.18926/AMO/66665
FullText URL 78_1_009.pdf
Author Akagi, Naoki| Kanematsu, Akihiro| Shigesaka, Koji| Shimatani, Kimihiro| Yamamoto, Shingo|
Abstract Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful.
Keywords bacillus Calmette-Guérin prostate granuloma prostate cancer bladder cancer prostate biopsy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 9
End Page 13
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419309
Web of Science KeyUT 001203658200010
JaLCDOI 10.18926/AMO/66664
FullText URL 78_1_001.pdf
Author Sun, Cuiming| Matsukawa, Akihiro|
Abstract Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
Keywords ERK-MAPK SPRED2 fibrosis macrophages
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419308
Web of Science KeyUT 001203658200006
FullText URL fulltext20240206-03.pdf
Author Ishii, Tomoya| Tsuchida, Natsuki| Hemelda, Niarsi Merry| Saito, Kirara| Bao, Jiyuan| Watanabe, Megumi| Toyoda, Atsushi| Matsubara, Takehiro| Sato, Mayuko| Toyooka, Kiminori| Ishihama, Nobuaki| Shirasu, Ken| Matsui, Hidenori| Toyoda, Kazuhiro| Ichinose, Yuki| Hayashi, Tetsuya| Kawaguchi, Akira| Noutoshi, Yoshiteru|
Keywords tailocin phage tail-like bacteriocin Allorhizobium vitris Alphaproteobacteria biocontrol crown gall disease interbacterial antagonism grapevine
Published Date 2024-01-18
Publication Title The ISME Journal
Volume volume18
Issue issue1
Publisher Oxford University Press (OUP)
Start Page 1
End Page 12
ISSN 1751-7362
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) [2024].
File Version publisher
DOI 10.1093/ismejo/wrad003
Web of Science KeyUT 001145343000001
Related Url isVersionOf https://doi.org/10.1093/ismejo/wrad003
FullText URL fulltext20240206-01.pdf
Author Mizutani, Yuna| Watanabe, Takaichi| Lopez, Carlos G.| Ono, Tsutomu|
Published Date 2024-01-18
Publication Title Soft Matter
Volume volume20
Issue issue7
Publisher Royal Society of Chemistry (RSC)
Start Page 1611
End Page 1619
ISSN 1744-683X
NCID AA12068335
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Royal Society of Chemistry 2024
File Version publisher
PubMed ID 38275008
DOI 10.1039/d3sm01626a
Web of Science KeyUT 001149540900001
Related Url isVersionOf https://doi.org/10.1039/d3sm01626a
FullText URL srfa_113_041_048.pdf
Author Tanaka, Yu| Watanabe, Tomoya| Katsura, Keisuke| Tsujimoto, Yasuhiro| Takai, Toshiyuki| Tanaka, Takashi Sonam Tashi| Kawamura, Kensuke| Saito, Hiroki| Homma, Koki| Mairoua, Salifou Goube| Ahouanton, Kokou| Ibrahim, Ali| Senthilkumar, Kalimuthu| Semwal, Vimal Kumar| Matute, Eduardo Jose Graterol| Corredor, Edgar| El-Namaky, Raafat| Manigbas, Norvie| Quilang, Eduardo Jimmy P.| Iwahashi, Yu| Nakajima, Kota| Takeuchi, Eisuke| Saito, Kazuki|
Abstract Rice (Oryza sativa L.) is one of the most important cereals, which provides 20% of the world’s food energy. However, its productivity is poorly assessed especially in the global South. Here, we provide a first study to perform a deep learning-based approach for instantaneously estimating rice yield using RGB images. During ripening stage and at harvest, over 22,000 digital images were captured vertically downwards over the rice canopy from a distance of 0.8 to 0.9m at 4,820 harvesting plots having the yield of 0.1 to 16.1 t ha-1 across six countries in Africa and Japan. A convolutional neural network (CNN) applied to these data at harvest predicted 68% variation in yield with a relative root mean square error (rRMSE) of 0.22. Even when the resolution of images was reduced (from 0.2 to 3.2cm pixel-1 of ground sampling distance), the model could predict 57% variation in yield, implying that this approach can be scaled by use of unmanned aerial vehicles. Our work offers low-cost, hands-on, and rapid approach for high throughput phenotyping, and can lead to impact assessment of productivity-enhancing interventions, detection of fields where these are needed to sustainably increase crop production.
Keywords Rice (Oryza sativa L.) rough grain yield convolutional neural network RGB images UAV
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2024-02-01
Volume volume113
Start Page 41
End Page 48
ISSN 2186-7755
language English
File Version publisher
FullText URL fulltext20240123-02.pdf
Author Takatsu, Fumiaki| Suzawa, Ken| Okazaki, Mikio| Shien, Kazuhiko| Yamamoto, Hiromasa| Watanabe, Mototsugu| Hayama, Makio| Ueno, Tsuyoshi| Sugimoto, Ryujiro| Maki, Yuho| Fujiwara, Toshiya| Okita, Riki| Inokawa, Hidetoshi| Tao, Hiroyuki| Hirami, Yuji| Matsuda, Eisuke| Kataoka, Kazuhiko| Yamashita, Motohiro| Sano, Yoshifumi| Matsuura, Motoki| Mizutani, Hisao| Toyooka, Shinichi|
Note © 2024 by The Society of Thoracic Surgeons. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Dec. 2024.|
Published Date 2024-01
Publication Title The Annals of Thoracic Surgery
Volume volume117
Issue issue1
Publisher Elsevier BV
Start Page 181
End Page 188
ISSN 0003-4975
NCID AA00533201
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by The Society of Thoracic Surgeons
File Version author
PubMed ID 35595090
DOI 10.1016/j.athoracsur.2022.04.052
Web of Science KeyUT 001137577900001
Related Url isVersionOf https://doi.org/10.1016/j.athoracsur.2022.04.052
FullText URL fulltext20240109-02.pdf
Author Tanaka, Yu| Watanabe, Tomoya| Katsura, Keisuke| Tsujimoto, Yasuhiro| Takai, Toshiyuki| Tanaka, Takashi Sonam Tashi| Kawamura, Kensuke| Saito, Hiroki| Homma, Koki| Mairoua, Salifou Goube| Ahouanton, Kokou| Ibrahim, Ali| Senthilkumar, Kalimuthu| Semwal, Vimal Kumar| Matute, Eduardo Jose Graterol| Corredor, Edgar| El-Namaky, Raafat| Manigbas, Norvie| Quilang, Eduardo Jimmy P.| Iwahashi, Yu| Nakajima, Kota| Takeuchi, Eisuke| Saito, Kazuki|
Published Date 2023-07-28
Publication Title Plant Phenomics
Volume volume5
Publisher American Association for the Advancement of Science (AAAS)
Start Page 0073
ISSN 2643-6515
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Yu Tanaka et al.
File Version publisher
DOI 10.34133/plantphenomics.0073
Web of Science KeyUT 001124487900004
Related Url isVersionOf https://doi.org/10.34133/plantphenomics.0073
FullText URL fulltext.pdf
Author Ando, Kakeru| Watanabe, Minoru| Watanabe, Nobuya|
Note © 2023 Optica Publishing Group. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.|
Published Date 2023-11-06
Publication Title Optics Express
Volume volume31
Issue issue23
Publisher Optica Publishing Group
Start Page 38529
End Page 38539
ISSN 1094-4087
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
File Version publisher
PubMed ID 38017956
DOI 10.1364/OE.500666
Web of Science KeyUT 001108090500007
Related Url isVersionOf https://doi.org/10.1364/OE.500666
Title Alternative The 2022 Incentive Award of the Okayama Medical Association in Cancer Research (2022 Hayashibara Prize and Yamada Prize)
Author Nishii, Kazuya|
Publication Title Journal of Okayama Medical Association
Published Date 2023-12-01
Volume volume135
Issue issue3
Start Page 109
End Page 112
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.109
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.109
Title Alternative WATANABE Shinichiro The study of ancient Chinese state
JaLCDOI 10.18926/66202
FullText URL jdc_003_308.pdf
Author TSUCHIGUCHI, Fuminori|
Amo Type 書評 (Book Review)
Publication Title Dynamics of Civilizations
Published Date 2024-03-25
Volume volume3
Publisher 岡山大学文明動態学研究所
Start Page 308
End Page 314
ISSN 2436-8326
Content Type Article
language Japanese
Copyright Holders © 2024 by RIDC
File Version publisher
FullText URL fulltext20231221-01.pdf suppl20231221-01.pdf
Author Miura, Kizuku| Fujihara, Michiko| Watanabe, Masaki| Takamura, Yuta| Kawasaki, Mayu| Nakano, Shogo| Kakuta, Hiroki|
Keywords RXR Fluorescence Solvatochromism Binding assay
Note © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Nov. 2025.|
Published Date 2023-11-15
Publication Title Bioorganic & Medicinal Chemistry Letters
Volume volume96
Publisher Elsevier BV
Start Page 129536
ISSN 0960-894X
NCID AA1079577X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier Ltd.
File Version author
PubMed ID 37913851
DOI 10.1016/j.bmcl.2023.129536
Web of Science KeyUT 001107680700001
Related Url isVersionOf https://doi.org/10.1016/j.bmcl.2023.129536
JaLCDOI 10.18926/AMO/66158
FullText URL 77_6_651.pdf
Author Watanabe, Daisuke| Hasebe, Yohei| Mitsui, Hiroshi| Oishi, Naoki| Kasai, Shin| Akahane, Koshi| Kojika, Satoru| Inukai, Takeshi|
Abstract A patient was born with a mass at the base of the thumb approximately 1.5 cm in diameter on the radial side of the fingers. The mass had globular swelling filled with hemorrhagic fluid and was dark red. X-rays and histology of the excised specimen suggested the diagnosis of gangrene and torsion of polydactyly. Prenatal torsion of polydactyly is not a common occurrence; moreover, prenatal torsion of polydactyly has only been found in ulnar polydactyly. Our case is a novel case of radial polydactyly that was gangrenous at birth owing to prenatal torsion. Diagnosing such a mass at the base of the thumb is important.
Keywords infant fingers thumb polydactyly torsion abnormality
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 651
End Page 653
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145940
Web of Science KeyUT 001164631200011
JaLCDOI 10.18926/AMO/66156
FullText URL 77_6_635.pdf
Author Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku|
Abstract In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
Keywords whey protein electrical stimulation muscle strength healthy volunteers
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 635
End Page 645
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145938
Web of Science KeyUT 001164631200009
JaLCDOI 10.18926/AMO/66153
FullText URL 77_6_613.pdf
Author Miyake, Yoshiaki| Namba, Yoshifumi| Mitani, Shigeru| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
Abstract The relationship between osteoarthritis (OA) of the lower extremity and shoulder OA has not been established. This study evaluated the prevalence of shoulder OA in patients with knee OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 105 patients with knee OA that were taken 1 week after they underwent primary knee arthroplasty to check for venous thromboembolism (VTE). The images were compared with CECT images of 110 control-group patients that were taken for the purpose of differentiating VTE. Shoulder OA was present in a significantly higher percentage of patients with knee arthroplasty than controls (29% versus 15%), and the difference was particularly pronounced in patients in their 70s (33%) compared to age-matched controls (11%). Patients with knee OA often use arm support to stand up or walk due to knee joint pain and muscle weakness, which places the weight-bearing shoulder at risk of developing OA.
Keywords shoulder osteoarthritis knee osteoarthritis weight-bearing shoulder knee arthroplasty
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 613
End Page 618
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145935
Web of Science KeyUT 001164631200006
FullText URL K0006949_abstract_review.pdf K0006949_fulltext.pdf K0006949_summary.pdf
Author YAMAMOTO, Shusei|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6949号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language English
Copyright Holders © 2023 Elsevier GmbH.
FullText URL K0006936_abstract_review.pdf K0006936_summary.pdf
Author WATANABE, Hiroki|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6936号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language Japanese
FullText URL K0006917_abstract_review.pdf K0006917_fulltext.pdf K0006917_other.pdf K0006917_summary.pdf
Author WINT, HAYMAR|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6917号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023. Published by The Company of Biologists Ltd
FullText URL K0006904_abstract_review.pdf K0006904_fulltext.pdf K0006904_other1.pdf K0006904_other2.pdf K0006904_summary.pdf
Author NAITO, Takanori|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6904号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023 The Authors.