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ID 30312
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Author
Murakami, Kazuharu
Hashimoto, Kozo
Ota, Zensuke
Abstract

The effects of angiotensin II, catecholamines and glucocorticoid on CRF-induced ACTH release were examined using rat anterior pituitary cells in monolayer culture. Synthetic ovine CRF induced a significant ACTH release in this system. Angiotensin II produced an additive effect on CRF-induced ACTH release. The ACTH releasing activity of CRF was potentiated by epinephrine and norepinephrine. Dopamine itself at 0.03-30 ng/ml did not show any significant effect on ACTH release, but it inhibited CRF-induced ACTH release. Corticosterone at 10(-7) and 10(-6)M inhibited CRF-induced ACTH release. These results indicate that angiotensin II, catecholamines and glucocorticoid modulate ACTH release at the pituitary level.

Keywords
corticotropin releasing factor(CRF)
ACTH release
angiotensin ?
catecholamines
glucocorticoid
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1984-08
Volume
volume38
Issue
issue4
Publisher
Okayama University Medical School
Start Page
349
End Page
355
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT