ID | 30312 |
JaLCDOI | |
FullText URL | |
Author |
Murakami, Kazuharu
Hashimoto, Kozo
Ota, Zensuke
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Abstract | The effects of angiotensin II, catecholamines and glucocorticoid on CRF-induced ACTH release were examined using rat anterior pituitary cells in monolayer culture. Synthetic ovine CRF induced a significant ACTH release in this system. Angiotensin II produced an additive effect on CRF-induced ACTH release. The ACTH releasing activity of CRF was potentiated by epinephrine and norepinephrine. Dopamine itself at 0.03-30 ng/ml did not show any significant effect on ACTH release, but it inhibited CRF-induced ACTH release. Corticosterone at 10(-7) and 10(-6)M inhibited CRF-induced ACTH release. These results indicate that angiotensin II, catecholamines and glucocorticoid modulate ACTH release at the pituitary level. |
Keywords | corticotropin releasing factor(CRF)
ACTH release
angiotensin ?
catecholamines
glucocorticoid
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1984-08
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Volume | volume38
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 349
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End Page | 355
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |