| ID | 40755 |
| FullText URL | |
| Title Alternative | Studies of the treatment of pulmonary epidermoid carcinoma Part 1. Sensitivity to various anticancer drugs against human pulmonary epidermoid carcinoma xenograft in the hamster
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| Author |
Seto, Takumi
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| Abstract | Chemotherapy is the only therapeutic modality applicable to patients with advanced pulmonary epidermoid carcinoma (PEC). However, the results of chemotherapy to PEC remain unsatisfactory. It is very important to have an accurate knowledge of the sensitivity of anticancer drugs against PEC in order to establish a successful chemotherapy. The in vivo sensitivity of 12 anticancer drugs was investigated using PEC cell line (EBC-1) xenografts in hamsters.
In the present study, adriamycin, ifosphamide, mitomycin C, methotrexate and cisdichlorodiammineplatinum (II) showed antitumor activity against EBC-1 cells, but the other 6 drugs (ACNU, bleomycin, 5-fluorouracil, neocarzinostatin, procarbazine and vincristine) have no antitumor activity against EBC-1 cells. These results suggest that combination chemotherapy with 3 or 4 drugs with antitumor activity in the present study may be effective to PEC.
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| Keywords | human lung cancer cell line
xenograft
chemosensitivity test
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| Published Date | 1989-06
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume101
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 573
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| End Page | 580
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/101/5-6/101_5-6_573/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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