result 49327 件
| JaLCDOI | 10.18926/AMO/51067 |
|---|---|
| FullText URL | 67_4_227.pdf |
| Author | Ryuko, Hiromasa| Otsuka, Fumio| |
| Abstract | Primary care physicians often encounter patients with fever of unknown origin and without apparent causes. Recent advances in laboratory medicine have facilitated diagnostic procedures;however, it is still difficult to determine the critical febrile factor at an early stage. We reviewed the medical records of 174 patients who were admitted due to a chief complaint of fever (＞37.5℃) to our hospital during the period from 2004 to 2010. The patients were categorized into patients with infection, inflammation, neoplasm and drug-induced fever. Based on the analysis done by category, it was revealed that the patient's age, body temperature and duration of fever were closely related to the final diagnosis. Serum CRP levels were significantly low in the nonbacterial infection group, while serum levels of sIL-2R were high in neoplasm and drug-induced cases. CRP level on admission was weakly but significantly correlated with body temperature, while duration of fever was inversely related to body temperature. The effectiveness of PET-CT and tissue biopsy for diagnosis was considerably high, particularly in the categories of neoplasm and nonspecific inflammation, respectively, though the effectiveness of bacterial culture was low. Thus, a careful review of physical and laboratory information including body temperature, CRP level, duration of fever, gender difference and history of medication is indispensable for diagnosis. Stepwise categorization and disease classification by comprehensive and systemic checkup are very helpful for determining the causes of fever. |
| Keywords | computed tomography (CT) C-reactive protein (CRP) fluorodeoxyglucose positron emission tomography (FDG-PET) fever of unknown origin (FUO) soluble interleukin-2 receptor (sIL-2R) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 237 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970321 |
| Web of Science KeyUT | 000323470100004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/51947 |
| JaLCDOI | 10.18926/AMO/51066 |
|---|---|
| FullText URL | 67_4_219.pdf |
| Author | Maruyama, Hidehiko| Nakamura, Makoto| Yonemoto, Naohiro| Kageyama, Misao| |
| Abstract | Cholestasis and thrombocytopenia are complications that affect infants born small for gestational age (SGA). In SGA infants, other vital organs develop at the expense of the liver, and the thrombopoietin produced by the liver is low, often resulting in cholestasis. We hypothesized that thrombocytopenia at birth can be used to predict cholestasis in very-low-birth-weight infants (VLBWIs) with SGA. This retrospective cohort study enrolled VLBWIs with SGA admitted to a tertiary neonatal intensive care unit. A platelet cutoff value predictive of cholestasis was determined using receiver operating characteristic analysis. Multivariate logistic regression analysis was performed to evaluate the platelet cutoff value, and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Regarding the onset of cholestasis, survival analysis was performed by calculating the adjusted hazard ratios (HRs) and 95% CIs. A total of 87 infants were evaluated, and the platelet cutoff value was determined as 88×10(3) cells/μl. The adjusted OR for this platelet cutoff value was 10.52 (95% CI 2.26-55.93, p＝0.003), and the adjusted HR was 7.76 (95% CI 2.51-23.50, p＝0.0006). Thrombocytopenia is a useful predictor for cholestasis in VLBWIs with SGA. |
| Keywords | cholestasis platelet small for gestational age thrombocytopenia very low birth weight |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970320 |
| Web of Science KeyUT | 000323470100003 |
| JaLCDOI | 10.18926/AMO/51065 |
|---|---|
| FullText URL | 67_4_213.pdf |
| Author | Kawahara, Michiko| Sato, Shuhei| Ida, Yukiko| Watanabe, Masao| Fujishima, Mamoru| Ishii, Hiroaki| Hori, Keisuke| Kanazawa, Susumu| |
| Abstract | A relatively large number of women in their 40s with high-density breasts, in which it can be difficult to detect lesions, are encountered in mammography cancer screenings in Japan. Here, we retrospectively investigated factors related to breast density. Two hundred women (40-49 years old) were examined at the screening center in our hospital. Multivariate analysis showed that factors such as small abdominal circumference, high HDL cholesterol, and no history of childbirth were related to high breast density in women in their 40s undergoing mammography. Other non-mammographic screening methods should be considered in women with abdominal circumferences ＜76cm, HDL-C >53mg/dl, and no history of childbirth, as there is a strong possibility of these women having high-density breasts that can make lesion detection difficult. |
| Keywords | high-density breasts abdominal circumference high-density lipoprotein cholesterol childbirth mammography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 217 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970319 |
| Web of Science KeyUT | 000323470100002 |
| JaLCDOI | 10.18926/AMO/51064 |
|---|---|
| FullText URL | 67_4_203.pdf |
| Author | Ohuchi, Hideyo| |
| Abstract | A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved. In this review, I first introduce the concept of evolutionary developmental biology of the eye with a focus on photoreception, the fundamental property of retinal cells. Second, I summarize the early development of vertebrate eyes and the role of a homeobox gene, Lhx1, in subdivision of the retina into 2 domains, the neural retina and retinal pigmented epithelium of the optic primordium. The 2 retinal domains are essential components of the eye as they are found in such prototypic eyes as the extant planarian eye. Finally, I propose the presence of novel retinal cell subtypes with photosensory functions based on our recent work on atypical photopigments (opsins) in vertebrates. Since human diseases are attributable to the aberration of various types of cells due to alterations in gene expression, understanding the precise mechanisms of cellular diversification and unraveling the molecular profiles of cellular subtypes are essential to future regenerative medicine. |
| Keywords | eye development evolution opsin photoreceptor |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970318 |
| Web of Science KeyUT | 000323470100001 |
| Author | Inouye, N.| Mitsuhata, K.| |
|---|---|
| Published Date | 1978-02 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Hiura, U.| Heta, H.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
| Author | Baba, I.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
| Author | Sakai, S.| Baba, I.| Ota, Y.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
| Author | Nakagawa, K.| Hattori, K.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
| Author | Fukuyama, T.| Kurozumi, T.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue3 |
| Content Type | Departmental Bulletin Paper |
| Author | Hayashi, J.| Takahashi, R.| Moriya, I.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue3 |
| Content Type | Departmental Bulletin Paper |
| Author | Konishi, T.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue3 |
| Content Type | Departmental Bulletin Paper |
| Author | Yasuda, S.| Okinaga, Y.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue3 |
| Content Type | Departmental Bulletin Paper |
| Author | 大原農業研究所| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue3 |
| Content Type | Departmental Bulletin Paper |
| Author | Maitani, T.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Kimura, K.| Takasu, K.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Ohtaki, E.| Seo, T.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Seo, T.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Suzuki, Hideyuki| Kato, Jun| Kuriyama, Motoaki| Hiraoka, Sakiko| Kuwaki, Kenji| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2010-03-14 |
| Publication Title | World Journal of Gastroenterology |
| Volume | volume16 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Takasu, K.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
