result 18742 件
| Author | Hanaa, E.Sayed| Hossam, A.Gabbar| Soheir, A. Fouadc| Khalil, M. Ahmedc| Miyazaki, Shigeji| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Hanaa, E.Sayed| Hossam, A.Gabbar| Miyazaki, Shigeji| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Handa, Hisashi| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Matsui Takeshi| Sakawa Masatoshi| Kato Kosuke| Matsumoto Koichi| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Hara Akira| Yamaguchi Tomohisa| Ichimura Takumi| Takahama Tetsuyuki| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Mera Kazuya| Ichimura Takumi| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/14788 |
|---|---|
| Title Alternative | 肺気腫と喘息のHRCT上のlow attenuation are（LAA）の性質の差。喫煙との関連を含めて |
| FullText URL | 74_035_041.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | The low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) was evaluated in 20 asthmatics (10 ex-smokers and 10 never-smokers) and 10 patients with pulmonary emphysema (all ex-smokers) by ventilatory function, lung volume, DLco, and a ratio of expiratory LAA/inspiratory LAA. 1 . The % LAA of the lungs on HRCT was significantly larger in patients with pulmonary emphysema(PE) than in those with asthma, but there was not significant difference in % LAA between ex-smokers and never-smokers of asthmatics. 2. A ratio of expiratory Winspiratory LAA was significantly higher in patients with PE than in those with asthma , and the ratio was significantly higher in ex-smokers of asthmatics than in never-smokers (p<0.05). 3 . The difference in % residual volume and % DLco was significant between asthma and PE , and between ex - smokers and never-smokers of asthmatics (% RV : p<0.05, DLco : p<0.05) . 4 . The difference in the values of % FVC, % FEV(1) .O, and FEV1.0% was significant between asthma and PE, but not significant between ex-smokers and never- smokers of asthmatics. The results suggest that the difference in a ratio of expiratory W inspiratory LAA, % RV and % DLco was significant between ex - smokers and never - smokers of asthmatics , and cigarette smoking induces more irreversible changes of the lungs. |
| Keywords | low attenuation area asthma pulmonary emphysema cigarette smoking |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 35 |
| End Page | 41 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308507 |
| JaLCDOI | 10.18926/14784 |
|---|---|
| Title Alternative | 長期間の喫煙は高齢者気管支喘息における気道過敏性と関連した白血球LTB4産生を亢進させる |
| FullText URL | 74_018_025.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | Abstract : Influence of cigarette smoking on leukotriene 84 (LTB4) generation by leucocytes associated with bronchial hyperresponsiveness was examined in 110 patients with asthma. l. The frequency of positive RAST score for inhalant allergens and LTB4 generation by leucocytes were significantly larger in previous and current smokers than in nonsmokers. 2. In nonsmokers, bronchial hyperresponsiveness was significantly higher in asthmatics under the age of 49 years compared with that in patients between 50 and 59 years, between 60 and 69 years, and those over age 70 years. In contrast, no significant differences were present between bronchial hyperresponsiveness and patient age in previous and current smokers. 3. In patients over age 60, bronchial hyperresponsiveness was significantly higher in previous and current smokers than in nonsmokers. In these patients, LTB4 generation was significantly more increased in previous and current smokers than in nonsmokers. 4. A significant correlation was observed in asthmatics of nonsmokers between LTB4 generation and bronchial hyperresponsiveness . 5. LTC4 generation was significantly higher in previous and current smokers than in nonsmokers in patients under age 49 years. These results show that in patients over age 60 years, cigarette smoking induces an increase in the generation of LTB4, leading to an increase in bronchial hyperresponsiveness . |
| Keywords | cigarette smoking asthma LTB4 generation LTC4 generation bronchial hyperresponsiveness |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 18 |
| End Page | 25 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308359 |
| JaLCDOI | 10.18926/14783 |
|---|---|
| FullText URL | 74_011_017.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | Clinical effects of long-term spa therapy for 4 years were estimated in 8 patients of pulmonary emphysema (4 with spa therapy and 4 without spa therapy) by pulmonary function and morphological changes of peripheral airspaces of the lung on
high - resolution computed tomography (HRCT).
1 . The values of % FVC, % FEV1.0, and FEV 1.0% did not significantly change for 4year observation both in patients with spa therapy and those without spa therapy.
2. The OLco value significantly decreased from 69.9% at the initial level to 48.8% after 4-year observation in patients without spa therapy (p |
| Keywords | spa therapy (温泉療法) pulmonary emphysema (,肺気腫) % RV % DLco % low attenuation area of the lung |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 11 |
| End Page | 17 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308395 |
| JaLCDOI | 10.18926/14782 |
|---|---|
| Title Alternative | Spa therapy for patients with respiratory disease. Analysis of 2295 patients admitted at Misasa Medical Center for last 22 years from 1982 to 2003 |
| FullText URL | 74_001_010.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| |
| Abstract | 1982年から2003年までの22年間に当医療センターで入院加療した2295例を対象に5年間毎にその年次推移を検討した｡2295例のうちわけは,気管支喘息1400例(61.0%),COPD510例(22.2%),その他385例であった｡1.気管支喘息は,第1期(1982-1986年)の5年間では,平均11.4例/年であったが第4期(1997-2001年)では平均93例と初期と比べ8.2倍の増加が見られた｡また,第5期(最近の2年間)では87.0例/年であった｡そのなかのSDIA(steroid-dependentintractableasthma)の頻度は初期の68.4%から第4期では29.0%,第5期23.6%にまで低下する傾向を示した｡ 2.COPD症例は,初期の5年間(1982-1986年)では平均5.2例/年から第4期には44.6例/年へと8.7倍の,また第5期では47.5例/年へと9.1倍の増加が見られた｡また,そのなかの肺気腫が占める割合は初期の19.2%から第4期では76.7%,第5期では87.4%と明らかな増加傾向を示した. 3.気管支喘息およびCOPD症例の年齢別検討では,60歳以上の症例の頻度は第1期では30.1%であったが,第4期では68.0%,そして第5期では87.4%と,年々その頻度は高くなっていく傾向が見られた｡すなわち,最近22年間の年次推移からは,温泉療法を必要とする呼吸器疾患患者が増加しつつあること,そしてその年令は年々高くなる傾向にあることが示されている｡ |
| Keywords | 喘息 COPD 温泉療法 高齢者 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308446 |
| JaLCDOI | 10.18926/14775 |
|---|---|
| Title Alternative | A case of anti - neutrophil cytoplasmic autoantibody-associated vasculitis: Resolution after early diagnosis |
| FullText URL | 73_088_092.pdf |
| Author | Ichikawa, Hirohisa| Ashida, Kozo| Ono, Katsuichiro| Takata, Shingo| Yokoi, Tadashi| Nagata, Takuya| Okamoto, Makoto| Tsugeno, Hirohumi| Nishida, Norikazu| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Noguchi, Yoshinori| Tanimoto, Mitsune| |
| Abstract | 症例は76歳男性03年前肺気腫と診断された｡今回呼吸器リハビリテーション目的で当院に入院の運びとなった｡入院時より37-38'Cの発熱を認め,下気道感染を疑い抗生剤で加療したが改善しなかった.入院時の検尿検査で蛋白･潜血陽性であり,血清MPO-ANCAが307U/mlと高値を示した｡血清クレアチニン値も徐々に上昇してきたため,MPO-ANCA関連血管炎と診断した.プレドニゾロン投与を開始したところ,症状及び検査所見は速やかに改善した. |
| Keywords | ANCA関連血管炎 早期診断 顕微鏡的多発血管炎 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 88 |
| End Page | 92 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308580 |
| JaLCDOI | 10.18926/14774 |
|---|---|
| Title Alternative | A case of Parkinson's disease associated with bromocriptine - induced leukopenia and throm-bocytopenia |
| FullText URL | 73_084_087.pdf |
| Author | Takata, Shingo| Mifune, Takashi| Mitsunobu, Fumihiro| Okamoto, Makoto| Nishida, Norikazu| Tsugeno, Hirofumi| Ashida, Kozo| Hosaki, Yasuhiro| Yokoi, Tadashi| Tanizaki, Yoshiro| Niiya, Kenji| Tanimoto, Mitsune| |
| Abstract | 症例は67歳,女性｡以前からパーキンソン病にて加療されていたが,リハビリテーション目的で当院入院した.入院時白血球数,血小板数正常であったが,bromocriptine投与開始後白血球減少,血小板減少を認めた.薬剤性白血球減少症及び血小板減少症を疑い, bromocriptine投与中止するとともにfilgrastim投与により,白血球減少,血小板減少は改善した。誘発試験施行し白血球減少を認めた｡Bromocriptineによる白血球減少症,血小板減少症の報告は少なく,我々の検索しえた範円内では本症例を含めて2例のみであった。Bromocriptineには安全性や神経保護作用に関して多くのデータの蓄積があるが,安全性に十分な注意が必要であると考えられた｡ |
| Keywords | パーキンソン病 (Parkinson's disease) ブロモクリプチン (Bromocriptine) 白球血減少症 (Leukopenia) 血小板減少症 (Thrombocytopenia) フィルグラスチム (Filgrastim) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 84 |
| End Page | 87 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308217 |
| JaLCDOI | 10.18926/14773 |
|---|---|
| Title Alternative | ’あくび’と胸痛を訴えた気管支喘息の1症例 |
| FullText URL | 73_081_083.pdf |
| Author | Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | We present a case of a patient with asthma who developed yawning associated with anterior chest pain. She was admitted due to severe anterior chest pain, wheezing and dyspnea. Although the frequency of the symptoms decreased, she began to experience frequent episodes of yawning at night accompanied by tears. While she experienced yawning, although PEF (peak expiratory flow) decreased, no asthmatic symptoms, such as wheezing or dyspnea were observed. The yawning was improved markedly by bronchodilators and a leukotriene receptor antagonist, and moderately improved by corticosteroids. We speculated that yawning is a clinical manifestation of asthma that responds to treatment. |
| Keywords | yawning chest pain nocturnal dyspnea asthma |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 81 |
| End Page | 83 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308373 |
| JaLCDOI | 10.18926/14772 |
|---|---|
| Title Alternative | Influences of aging and cigarette smoking on pathophysiology in elderly patients with asthma (2) |
| FullText URL | 73_093_101.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| |
| Abstract | 高齢者気管支喘息について.IgEにmediateされるアレルギー反応の特徴、臨床病態,肺機能(換気機能,ガス交換),気腫化傾向,治療上の問題点などを検討した. 1.高齢者喘息におけるIgE抗体の関与は予想外に多く,しかもアレルギーの家族歴を有する症例で特に高度であった。また,加齢とともに感作される抗原の種類が異なってくることが示唆された。 2.臨床病態では,単純性気管支攣縮型に比べ,気管支攣縮+過分泌型や細気管支閉塞型が増加する傾向が見られた｡ 3.肺機能では,airflow (% FVC,FEV1.0%)ゃlung volume(% RV)をあらわすパラメーターは,いずれも70才以上の症例で若青年者喘息に比べ有意に低下していることが示された｡また,transfer factor(% DLco)も70才以上の症例では有意の低下傾向が見られた。 4.HRCT上の1950HU以下の肺の% UIAは,加齢とともに増加する傾向を示し,% RVの増加と同様肺の気腫化傾向が見られること,しかし,この現象が肺気腫へと移行することはないことが示された. 5.治療上では,薬物療法よりも気道の浄化を促す吸入や水中運動(温泉療法など)が重要であると考えられた｡ |
| Keywords | 高齢者喘息 IgE抗体 % RV % DLco 気腫可傾向 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 93 |
| End Page | 101 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308220 |
| JaLCDOI | 10.18926/14771 |
|---|---|
| Title Alternative | 食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討 |
| FullText URL | 73_075_080.pdf |
| Author | Mizushima, Takaaki| Ochi, Koji| Emori, Yasuyuki| Tanioka, Hiroaki| Sawa, Kiminari| Fujioka, Shinichi| Shinji, Toshiyuki| Koide, Norio| Tanizaki, Yoshiro| |
| Abstract | Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells. |
| Keywords | esophageal carcinoma Wnt TCF beta-catenin |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 75 |
| End Page | 80 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308224 |
| JaLCDOI | 10.18926/14770 |
|---|---|
| Title Alternative | QOL in OA patients |
| FullText URL | 73_072_074.pdf |
| Author | Yokoi, Tadashi| Senda, Masuo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Nishida, Norikazu| Tsugeno, Hirofumi| Okamoto, Makoto| Nagata, Takuya| Takata, Shingo| Tanizaki, Yoshiro| Inoue, Hajime| |
| Abstract | 近年QOLが重視されるようになってきている｡MOS short form 36 health survey(以下SF-36と略す)は,国際的レベルでの基準とされるべく開発された非疾患特異的HRQOL尺度である.今回,我々は当院でリハビリテーションをうけているOA患者を対象に温泉療法の効果をSF-36を用いてQOLの変化を調べたoSF-36の8項目をそれぞれ算出し,温泉療法前後でのQOLの比較を行った｡pCSは36.4から37.1へ,MCSは53.0から55.4へ上昇したことより,身体･健東面ともに効果があると考えられた｡ |
| Keywords | SF-36 生活の質 (Quality of Life) 関節症 (Osteoarthritis) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 72 |
| End Page | 74 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308372 |
| JaLCDOI | 10.18926/14768 |
|---|---|
| Title Alternative | 気管支喘息に対する温泉療法とα-リノレン酸強化食の効果 |
| FullText URL | 73_055_063.pdf |
| Author | Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| Tnimoto, Mitsune| |
| Abstract | N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil- rich diet (rich in n-3 fatty acid)were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil- rich diet - rich in a -linolenic acid (alpha-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P |
| Keywords | bronchial asthma spa therapy perilla seed oil alpha -linolenic acid Leukotriene C4 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 55 |
| End Page | 63 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308428 |
| JaLCDOI | 10.18926/14767 |
|---|---|
| Title Alternative | 高齢者喘息のIgEにmediateされるアレルギー反応におよぽす喫煙の影響 |
| FullText URL | 73_049_054.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | The influence of cigarette smoking on the pathophysiology of asthma in the elderly remains controversial. In this study, the inluence of cigarette smoking on IgE - mediated allergy including the generation of leukotrienes B4 (LTB4) and C4 (LTC4) was examined in forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex - smokers). The frequency of patients with serum IgE more than 200 IU/ml was significantly larger in smoking asthmatics than in non - smoking asthmatics. The incidence of patients with positive RAST score for inhalant allergens, was also significantly higher in patients with a history of smoking than in those without a smoking history. There were no significant differences in the frequency of patients with positive RAST and those with serum IgE more than 200 IU/ml between non-smoking asthmatics and patients with pulmonary emphysema. The generation of leukotriene B4 (LTB4) by leukocytes was significantly more increased in ex-smokers than in never-smokers in the elderly asthmatics. The results suggest the possibility that cigarette smoking enhances IgE - mediated allergy in elderly patients with asthma. |
| Keywords | cigarette smoking IgE - mediated allergy LTB4 LTC4 generation elderly asthmatics |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 49 |
| End Page | 54 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308483 |
| JaLCDOI | 10.18926/14766 |
|---|---|
| FullText URL | 73_044_048.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of cigarette smoke on pulmonary function, airflow, lung volume, and transfer factor in patients with asthma was examined in 40 subjects over the age of 70 years (20 ever-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex-smokers). The ventilatory parameters showing airflow limitation (% FEV(1) and FEV(1)%) were not significantly different between ever-smokers and never-smokers of elderly asthmatics. In contrast, % FEV(1) and FEV(1) % values were significantly lower in patients with pulmonary emphysema than in those with asthma with or without a history of smoking. The % RV value was significantly larger and % DLco value was significantly more decreased in ever-smokers compared with neversmokers of the elderly asthmatics. However, there were no significant differences in % RV and % DLco values between asthmatics with a history of smoking and patients with pulmonary emphysema. The results show that cigarette smoke inflluences % RV and % DLco, but not % FEV(1) and FEV(1) %, suggesting airflow limitation of large and moderate size airways. |
| Keywords | cigarette smoking FEV(1) % % RV % DLco elderly asthmatics |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 44 |
| End Page | 48 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308159 |
| JaLCDOI | 10.18926/14764 |
|---|---|
| Title Alternative | lgEにmediatedされるアレルギ反応― 、肺機能、HRCT上の肺のlow attenuatjonarea (LAA)、およびLTB4,LTC4産生から見た喘息の病態に対する加齢の影響 |
| FullText URL | 73_031_038.pdf |
| Author | Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of aging on the pathophysiology of asthma in the elderly was examined in 40 patients (20 younger asthmatics under the age of 50 years, mean age 32.5 years and 20 elderly asthmatics over the age of 70 years, mean age 74.3 years), relating to IgE - mediated allergy, pulmonary function, low attenuation area (LAA) of the lungs on HRCT, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes. The frequency of patients with serum IgE of more than 200 IU/ml, and the incidence of those with a positive RAST score for inhalant allergens were significantly higher in younger patients than in elderly subjects. The values of % FVC, % FEV1 and FEV 1% were significantly larger in younger patients compared with elderly subjects. The % RV was significantly larger in elderly patients than in younger patients, however, the difference in % DLco was not significant between the two age groups. The LAA of the lungs on HRCT and the ratio of expiratory LAA (exp LAA) to inspiratory LAA (ins LAA) were also significantly larger in elderly asthmatics than in younger subjects. The generation of LTB4 and LTC4 was larger in younger patients than in elderly subjects, and LTB4 generation was significantly larger in younger subjects compared with elderly subjects. These results suggest that changes in IgE-mediated allergy, airflow and lung volume accompanied with hyperinflation are often observed in elderly asthmatics. |
| Keywords | IgE-mediated allergy pulmonary function elderly asthmatics HRCT % RV |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 31 |
| End Page | 38 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308601 |
