start-ver=1.4 cd-journal=joma no-vol=192 cd-vols= no-issue= article-no= start-page=155 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effectiveness of exercise therapy on chemotherapy-induced peripheral neuropathy in patients with ovarian cancer: A scoping review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background & aims. Exercise therapy is a potentially beneficial treatment option for chemotherapy-induced peripheral neuropathy (CIPN). However, there is a lack of consensus on the management of CIPN in patients with ovarian cancer. The purpose of this scoping review was to evaluate the evidence on the effectiveness of exercise therapy in patients with ovarian cancer and explore key physical fitness parameters.
Methods. A systematic electronic search was conducted using the MEDLINE, CINAHL, Web of Science, PEDro, and ClinicalTrials.gov databases. Two independent reviewers summarized the features and data from the literature regarding the effectiveness of exercise therapy for CIPN and the association between CIPN and physical fitness parameters.
Results. Ten articles involving 3402 participants were reviewed. The study design included one randomized controlled trial, one single-arm trial, one prospective cohort study, five retrospective cohort studies, and two cross-sectional studies. The mean patient age was >60 years in three studies and 50?60 years in six studies. The mean body mass index was >25.0 kg/m2 in six studies and not stated in four studies. In six references, patients received platinum and taxane-based chemotherapy. The effectiveness of an exercise therapy program for CIPN was reported in a randomized controlled trial. Two cross-sectional studies highlighted the association between daily physical inactivity and CIPN; two retrospective cohort studies showed an association between low skeletal muscle density and CIPN; one article demonstrated an association between physical dysfunction and CIPN.
Conclusion. This scoping review indicates that although evidence is lacking, exercise intervention programs for CIPN in patients with ovarian cancer have potential benefits, especially when focused on daily physical activity, skeletal muscle density, and physical function. en-copyright= kn-copyright= en-aut-name=KonumaMasanori en-aut-sei=Konuma en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaTomohiro en-aut-sei=Ikeda en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitomaTomohiro en-aut-sei=Mitoma en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShirakawaShinsuke en-aut-sei=Shirakawa en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MakiJota en-aut-sei=Maki en-aut-mei=Jota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KatayamaYoshimi en-aut-sei=Katayama en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HamadaMasanori en-aut-sei=Hamada en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagaoShoji en-aut-sei=Nagao en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= en-keyword=Ovarian cancer kn-keyword=Ovarian cancer en-keyword=Peripheral neuropathy kn-keyword=Peripheral neuropathy en-keyword=Sarcopenia kn-keyword=Sarcopenia en-keyword=Physical activity kn-keyword=Physical activity en-keyword=Exercise therapy kn-keyword=Exercise therapy END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue= article-no= start-page=31 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Incidence, Management, and Prevention of Gynecomastia and Breast Pain in Patients with Prostate Cancer Undergoing Antiandrogen Therapy: A Systematic Review and Meta-analysis of Randomized Controlled Trials en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and objective: In patients with prostate cancer treated with antiandrogen monotherapy, gynecomastia and breast pain are relatively common. In the setting of androgen receptor pathway inhibitors (ARPIs), the incidence of these adverse events (AEs) remains unclear. In addition, the effect of prophylactic treatment on gynecomastia remains uncertain. We aimed to evaluate the incidence of gynecomastia and breast pain in prostate cancer patients treated with ARPIs compared with androgen deprivation therapy (ADT) and the effect of prophylactic treatment for these AEs due to antiandrogen therapy.
Methods: In June 2024, we queried four databases?PubMed, Scopus, Web of Science, and Embase?for randomized controlled trials (RCTs) investigating prostate cancer treatments involving antiandrogen therapy. The endpoints of interest were the incidence of these AEs due to ARPIs and the effect of prophylactic treatment for these.
Key findings and limitations: Eighteen RCTs, comprising 5036 patients, were included in the systematic review and meta-analysis. ARPIs included enzalutamide, darolutamide, and apalutamide. The results indicated that patients who received ARPI monotherapy had a significantly higher incidence of gynecomastia than those who received ADT monotherapy (risk ratio [RR]: 5.19, 95% confidence interval [CI]: 3.58?7.51, p < 0.001). There was no significant difference in the incidence of gynecomastia between ARPI plus ADT therapy and ADT monotherapy (RR: 1.27, 95% CI: 0.84?1.93, p = 0.2). Prophylactic tamoxifen or radiotherapy reduced significantly the incidence of gynecomastia and breast pain caused by bicalutamide monotherapy.
Conclusions and clinical implications: We found that ARPI monotherapy increases the incidence of these AEs significantly compared with ADT. In contrast, ARPI plus ADT therapy did not result in a higher incidence of AEs. The use of either tamoxifen or radiotherapy was effective in reducing the incidence of these AEs due to bicalutamide monotherapy. These prophylactic treatments could reduce the incidence of AEs due to ARPI monotherapy. However, further studies are needed to clarify their efficacy.
Patient summary: Although androgen deprivation therapy (ADT) improves overall survival in patients with prostate cancer, it is associated with several complications. Androgen receptor pathway inhibitor (ARPI) monotherapy has emerged as a promising strategy for improving oncological outcomes in these patients. However, ARPI monotherapy increases gynecomastia and breast pain in prostate cancer patients compared with ADT, while ARPI plus ADT did not result in a higher incidence of adverse events. en-copyright= kn-copyright= en-aut-name=TsuboiIchiro en-aut-sei=Tsuboi en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SchulzRobert J. en-aut-sei=Schulz en-aut-mei=Robert J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LaukhtinaEkaterina en-aut-sei=Laukhtina en-aut-mei=Ekaterina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KarakiewiczPierre I. en-aut-sei=Karakiewicz en-aut-mei=Pierre I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShariatShahrokh F. en-aut-sei=Shariat en-aut-mei=Shahrokh F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=3 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=4 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=5 en-affil=Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= en-keyword=Antiandrogen therapy kn-keyword=Antiandrogen therapy en-keyword=Androgen deprivation therapy kn-keyword=Androgen deprivation therapy en-keyword=Androgen receptor pathway inhibitors kn-keyword=Androgen receptor pathway inhibitors en-keyword=Breast pain kn-keyword=Breast pain en-keyword=Gynecomastia kn-keyword=Gynecomastia END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=102575 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical and microbiological characteristics of high-level daptomycin-resistant Corynebacterium species: A systematic scoping review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction: Corynebacterium species potentially develop high-level daptomycin resistance (HLDR) shortly after daptomycin (DAP) administration. We aimed to investigate the clinical and microbiological characteristics of HLDR Corynebacterium infections.
Methods: We first presented a clinical case accompanied by the results of a comprehensive genetic analysis of the isolate, and then performed a systematic scoping review. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, we searched for articles with related keywords, including gCorynebacteriumh, gDaptomycin", and "Resistanceh, in the MEDLINE and Web of Science databases from the database inception to October 25, 2024. Clinical case reports and research articles documenting the isolation of HLDR Corynebacterium species, defined by a minimum inhibitory concentration of DAP at ?256 ƒÊg/mL, were deemed eligible for this review.
Results: Of 80 articles screened, seven case reports detailing eight cases of HLDR Corynebacterium infections, as well as five research articles, were included. C. striatum was the most common species (7/9 cases, 77.8 %), and prosthetic device-associated infections accounted for 66.7 % of the cases. Duration of DAP administration before the emergence of HLDR isolates ranged from 5 days to 3 months; three-quarters of the cases developed within 17 days. Three HLDR isolates were genetically confirmed to have an alteration in pgsA2. The majority of the patients were treated with either glycopeptides or linezolid, with favorable outcomes. In vitro experiments confirmed that C. striatum strains acquire the HLDR phenotype at higher rates (71 %?100 %) within 24 h of incubation, compared to other Corynebacterium strains.
Conclusion: DAP monotherapy, especially for prosthetic device-associated infections, can result in the development of HLDR Corynebacterium. Additional research is warranted to investigate the clinical implications of this potentially proliferating antimicrobial resistant pathogen. en-copyright= kn-copyright= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsujiShuma en-aut-sei=Tsuji en-aut-mei=Shuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AkazawaHidemasa en-aut-sei=Akazawa en-aut-mei=Hidemasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsushitaOsamu en-aut-sei=Matsushita en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences kn-affil= affil-num=4 en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences kn-affil= affil-num=5 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=Antimicrobial resistance kn-keyword=Antimicrobial resistance en-keyword=Corynebacterium kn-keyword=Corynebacterium en-keyword=Daptomycin kn-keyword=Daptomycin en-keyword=High-level daptomycin resistance kn-keyword=High-level daptomycin resistance en-keyword=pgsA2 kn-keyword=pgsA2 END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=5 article-no= start-page=e0302537 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240521 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The use of artificial intelligence in induced pluripotent stem cell-based technology over 10-year period: A systematic scoping review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Stem cell research, particularly in the domain of induced pluripotent stem cell (iPSC) technology, has shown significant progress. The integration of artificial intelligence (AI), especially machine learning (ML) and deep learning (DL), has played a pivotal role in refining iPSC classification, monitoring cell functionality, and conducting genetic analysis. These enhancements are broadening the applications of iPSC technology in disease modelling, drug screening, and regenerative medicine. This review aims to explore the role of AI in the advancement of iPSC research.
Methods
In December 2023, data were collected from three electronic databases (PubMed, Web of Science, and Science Direct) to investigate the application of AI technology in iPSC processing.
Results
This systematic scoping review encompassed 79 studies that met the inclusion criteria. The number of research studies in this area has increased over time, with the United States emerging as a leading contributor in this field. AI technologies have been diversely applied in iPSC technology, encompassing the classification of cell types, assessment of disease-specific phenotypes in iPSC-derived cells, and the facilitation of drug screening using iPSC. The precision of AI methodologies has improved significantly in recent years, creating a foundation for future advancements in iPSC-based technologies.
Conclusions
Our review offers insights into the role of AI in regenerative and personalized medicine, highlighting both challenges and opportunities. Although still in its early stages, AI technologies show significant promise in advancing our understanding of disease progression and development, paving the way for future clinical applications. en-copyright= kn-copyright= en-aut-name=VoQuan Duy en-aut-sei=Vo en-aut-mei=Quan Duy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoYukihiro en-aut-sei=Saito en-aut-mei=Yukihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IdaToshihiro en-aut-sei=Ida en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YuasaShinsuke en-aut-sei=Yuasa en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Faculty of Medicine, Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Cardiovascular Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Faculty of Medicine, Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Medicine, Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Medicine, Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=141 cd-vols= no-issue= article-no= start-page=106955 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vibriosis in South Asia: A systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives: South Asia remains home to foodborne diseases caused by the Vibrio species. We aimed to compile and update information on the epidemiology of vibriosis in South Asia.
Methods: For this systematic review and meta-analysis, we searched PubMed, Web of Science, EMBASE, and Google Scholar for studies related to vibriosis in South Asia published up to May 2023. A random-effects meta-analysis was used to estimate the pooled isolation rate of non-cholera-causing Vibrio species.
Results: In total, 38 studies were included. Seven of these were case reports and 22 were included in the meta-analysis. The reported vibriosis cases were caused by non-O1/non-O139 V. cholerae, V. parahaemolyticus, V. fluvialis, and V. vulnificus. The overall pooled isolation rate was 4.0% (95% confidence interval [CI] 3.0-5.0%) in patients with diarrhea. Heterogeneity was high (I-2 = 98.0%). The isolation rate of non-O1/non-O139 V. cholerae, V. parahaemolyticus, and V. fluvialis were 9.0 (95% CI 7.0-10.0%), 1.0 (95% CI 1.0-2.0%), and 2.0 (95% CI: 1.0-3.0%), respectively. Regarding V. parahaemolyticus, O3:K6 was the most frequently isolated serotype. Cases peaked during summer. Several studies reported antibiotic-resistant strains and those harboring extended-spectrum beta-lactamases genes.
Conclusions: This study demonstrates a high burden of infections caused by non-cholera-causing Vibrio species in South Asia. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KhatiwadaJanuka en-aut-sei=Khatiwada en-aut-mei=Januka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Social Work Institute kn-affil= affil-num=5 en-affil=Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Vibrio parahaemolyticus kn-keyword=Vibrio parahaemolyticus en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus en-keyword=Vibrio mimicus kn-keyword=Vibrio mimicus en-keyword=Vibrio fluvialis kn-keyword=Vibrio fluvialis en-keyword=Seafood kn-keyword=Seafood en-keyword=Gastroenteritis kn-keyword=Gastroenteritis END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=2 article-no= start-page=987 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induced Pluripotent Stem Cell-Derived Cardiomyocytes Therapy for Ischemic Heart Disease in Animal Model: A Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ischemic heart disease (IHD) poses a significant challenge in cardiovascular health, with current treatments showing limited success. Induced pluripotent derived-cardiomyocyte (iPSC-CM) therapy within regenerative medicine offers potential for IHD patients, although its clinical impacts remain uncertain. This study utilizes meta-analysis to assess iPSC-CM outcomes in terms of efficacy and safety in IHD animal model studies. A meta-analysis encompassing PUBMED, ScienceDirect, Web of Science, and the Cochrane Library databases, from inception until October 2023, investigated iPSC therapy effects on cardiac function and safety outcomes. Among 51 eligible studies involving 1012 animals, despite substantial heterogeneity, the iPSC-CM transplantation improved left ventricular ejection fraction (LVEF) by 8.23% (95% CI, 7.15 to 9.32%; p < 0.001) compared to control groups. Additionally, cell-based treatment reduced the left ventricle fibrosis area and showed a tendency to reduce left ventricular end-systolic volume (LVESV) and end-diastolic volume (LVEDV). No significant differences emerged in mortality and arrhythmia risk between iPSC-CM treatment and control groups. In conclusion, this meta-analysis indicates iPSC-CM therapy's promise as a safe and beneficial intervention for enhancing heart function in IHD. However, due to observed heterogeneity, the efficacy of this treatment must be further explored through large randomized controlled trials based on rigorous research design. en-copyright= kn-copyright= en-aut-name=VoQuan Duy en-aut-sei=Vo en-aut-mei=Quan Duy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoYukihiro en-aut-sei=Saito en-aut-mei=Yukihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IidaToshihiro en-aut-sei=Iida en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YuasaShinsuke en-aut-sei=Yuasa en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Cardiovascular Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=induced pluripotent stem cell kn-keyword=induced pluripotent stem cell en-keyword=ischemic heart disease kn-keyword=ischemic heart disease en-keyword=outcomes kn-keyword=outcomes en-keyword=safety kn-keyword=safety en-keyword=meta-analysis kn-keyword=meta-analysis END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue= article-no= start-page=102554 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Shigellosis in Southeast Asia: A systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Southeast Asia is attractive for tourism. Unfortunately, travelers to this region are at risk of becoming infected with Shigella. We conducted a meta-analysis to provide updates on Shigella prevalence in Southeast Asia, along with their serogroups and serotypes.
Methods: We conducted a systematic search using PubMed, EMBASE, and Web of Science for peer-reviewed studies from 2000 to November 2022. We selected studies that detected Shigella in stools by culture or polymerase chain reaction (PCR). Two reviewers extracted the data using a standardized form and performed quality assessments using the Joanna Briggs Institute checklist. The random effects model was used to estimate the pooled prevalence of Shigella.
Results: During our search, we identified 4376 studies. 29 studies (from six Southeast Asian countries) were included in the systematic review, 21 each in the meta-analysis of the prevalence of Shigella (Sample size: 109545) and the prevalence of Shigella serogroups.
The pooled prevalence of Shigella was 4% (95% CI: 4?5%) among diarrhea cases. Shigella sonnei was the most abundant serogroup in Thailand (74%) and Vietnam (57%), whereas Shigella flexneri was dominant in Indonesia (72%) and Cambodia (71%). Shigella dysenteriae and Shigella boydii were uncommon (pooled prevalence of 1% each). The pooled prevalence of Shigella was 5% (95% CI: 4?6%) in children aged <5 years. The pooled prevalence showed a decreasing trend comparing data collected between 2000?2013 (5%; 95% CI: 4?6%) and between 2014?2022 (3%; 95% CI: 2?4%). Shigella prevalence was 6% in studies that included participants with mixed pathogens versus 3% in those without. Shigella flexneri serotype 2a was the most frequently isolated (33%), followed by 3a (21%), 1b (10%), 2b (3%), and 6 (3%).
Conclusions: This study provides compelling evidence for the development of effective Shigella vaccines for residents of endemic regions and travellers to these areas. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitraDebmalya en-aut-sei=Mitra en-aut-mei=Debmalya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KhatiwadaJanuka en-aut-sei=Khatiwada en-aut-mei=Januka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Collaborative Research Centre of Okayama University for Infectious Diseases in India at ICMR-NICED kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Social Work Institute kn-affil= affil-num=6 en-affil=Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases kn-affil= affil-num=7 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Shigella vaccine kn-keyword=Shigella vaccine en-keyword=Shigella sonnei kn-keyword=Shigella sonnei en-keyword=Shigella flexneri kn-keyword=Shigella flexneri en-keyword=Diarrhea kn-keyword=Diarrhea en-keyword=Dysentery kn-keyword=Dysentery en-keyword=Shiga toxin kn-keyword=Shiga toxin en-keyword=Travel kn-keyword=Travel END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=22 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Colonization with extended-spectrum beta-lactamase-producing Escherichia coli and traveler's diarrhea attack rates among travelers to India: a systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background India is an attractive destination for travelers. Unfortunately, numerous reports exist on traveler's diarrhea (TD) and fecal colonization with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) among international travelers visiting India. Here, we systematically reviewed studies published on the acquisition of ESBL-EC and TD attack rates among international visitors to India. Methods Design: Systematic review and meta-analysis. A systematic search was performed using Google Scholar, PubMed, EMBASE, Web of Science, and gray literature from 2000 to December 2021, for studies containing data for ESBL-EC acquisition or TD experience related to a trip to India. Random effects models were used to compute the prevalence of ESBL-EC acquisition and TD attack. Results The literature search yielded a total of 5023 records. Of these, 31 met our inclusion criteria for systematic review and only 17 could be meta-analyzed (9 for TD, and 8 for ESBL-EC). The overall pooled attack rate of TD was 39% (95% confidence interval, CI: 25-53%). In studies where travelers' memory was used to diagnose TD, the pooled attack rate of TD was slightly higher (42%, 95% CI: 21-64%) compared to those where TD was objectively documented (33%, 95% CI: 17-49%). There were significant risks to be colonized with ESBL-EC among the travelers who experienced TD. The pooled rate of ESBL-EC colonization was 72% (CI: 67-78%). Most ESBL-EC produced CTX-M-15 enzyme. Furthermore, most of the travelers who acquired ESBL-EC were from highly industrialized countries recruited from travel clinics: Canada (n = 80), Germany (n = 69), Netherlands (n = 20), Sweden (n = 18), Japan (n = 10), Finland (n = 8), USA (n = 7), Spain (n = 5), and Denmark (n = 3). Conclusions TD pooled attack rate and ESBL-EC acquisition among international travelers visiting India were high in this study. However, we cannot make generalizations based upon this TD pooled attack rate for the current situation, due to a lack of current data. Our study highlights that travelers should be advised on TD to ensure that they do not disregard the risk of contracting TD and be better prepared as a result. It also illustrates the importance of international travel in acquiring antibiotic-resistant Escherichia coli. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ESBL-EC kn-keyword=ESBL-EC en-keyword=Traveler's diarrhea kn-keyword=Traveler's diarrhea en-keyword=International travelers kn-keyword=International travelers en-keyword=India kn-keyword=India en-keyword=Meta-analysis kn-keyword=Meta-analysis END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=457 end-page=463 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy of 0.01% Atropine Eye Drops in Controlling Myopia Progression and Axial Elongation in Children: A Meta-analysis Based on Randomized Controlled Trials en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the preventive effects of 0.01% atropine eye drops against myopia progression and axial elongation in children, a meta-analysis was carried out based on data obtained from PubMed and Web of Science as of August 1, 2021. Randomized controlled trials (RCTs) that enrolled myopic children who had received atropine for at least one year were included in this study, Key search terms included myopia, children, and 0.01% or low-dose atropine. Heterogeneity was quantified by I2 statistics, and meta-analyses were performed using the fixed-effect model. Five RCTs involving 809 unique children were analyzed. One trial was excluded because of a poor Jadad score and markedly rapid myopia progression in controls. The mean effect sizes for 12 months in myopia progression and axial elongation synthesized from the remaining 4 RCTs were 0.20 (95% CI: 0.13 to 0.27) D and ?0.08 (?0.11 to ?0.04) mm, respectively (p<0.0001). The corresponding inhibition ratios were 28% and 19%. I2 statistics were 6% or less. Sensitivity analysis and funnel plots demonstrated the robustness of the estimation. The 0.01% atropine-induced inhibition ratio for myopia progression in Asian children was roughly half of that originally reported and did not reach the minimum requirement for clinical treatment. en-copyright= kn-copyright= en-aut-name=SunWeiying en-aut-sei=Sun en-aut-mei=Weiying kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HasebeSatoshi en-aut-sei=Hasebe en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Ophthalmology 2, Kawasaki Medical School kn-affil= affil-num=2 en-affil=Department of Ophthalmology 2, Kawasaki Medical School kn-affil= en-keyword=myopia kn-keyword=myopia en-keyword=0.01% atropine kn-keyword=0.01% atropine en-keyword=low-dose atropine kn-keyword=low-dose atropine en-keyword=axial length kn-keyword=axial length en-keyword=myopia progression kn-keyword=myopia progression END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=11 article-no= start-page=2095 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211113 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Rapid Diagnostic Tests for the Detection of Vibrio cholerae O1: An Updated Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The rapid diagnosis of cholera contributes to adequate outbreak management. This meta-analysis assesses the diagnostic accuracy of cholera rapid tests (RDTs) to detect Vibrio cholerae O1. Methods: Systematic review and meta-analysis. We searched four databases (Medline, EMBASE, Google Scholar, and Web of Science up to 8 September 2021) for studies that evaluated cholera RDTs for the detection of V. cholerae O1 compared with either stool culture or polymerase chain reaction (PCR). We assessed the studies' quality using the QUADAS-2 criteria. In addition, in this update, GRADE approach was used to rate the overall certainty of the evidence. We performed a bivariate random-effects meta-analysis to calculate the pooled sensitivity and specificity of cholera RDTs. Results: Overall, 20 studies were included in this meta-analysis. Studies were from Africa (n = 11), Asia (n = 7), and America (Haiti; n = 2). They evaluated eight RDTs (Crystal VC-O1, Crystal VC, Cholkit, Institut Pasteur cholera dipstick, SD Bioline, Artron, Cholera Smart O1, and Smart II Cholera O1). Using direct specimen testing, sensitivity and specificity of RDTs were 90% (95% CI, 86 to 93) and 86% (95% CI, 81 to 90), respectively. Cholera Sensitivity was higher in studies conducted in Africa [92% (95% CI, 89 to 94)] compared with Asia [82% (95% CI, 77 to 87)]. However, specificity [83% (95% CI, 71 to 91)] was lower in Africa compared with Asia [90% (95% CI, 84 to 94)]. GRADE quality of evidence was estimated as moderate. Conclusions: Against culture or PCR, current cholera RDTs have moderate sensitivity and specificity for detecting Vibrio cholerae O1. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=rapid test kn-keyword=rapid test en-keyword=cholera kn-keyword=cholera en-keyword=Vibrio cholera O1 kn-keyword=Vibrio cholera O1 en-keyword=sensitivity kn-keyword=sensitivity en-keyword=specificity kn-keyword=specificity en-keyword=accuracy kn-keyword=accuracy en-keyword=update kn-keyword=update END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=12 article-no= start-page=7141 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Long-Term Kinetics of Serological Antibodies against Vibrio cholerae Following a Clinical Cholera Case: A Systematic Review and Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Approximately 2.9 million people worldwide suffer from cholera each year, many of whom are destitute. However, understanding of immunity against cholera is still limited. Several studies have reported the duration of antibodies following cholera; however, systematic reviews including a quantitative synthesis are lacking. Objective: To meta-analyze cohort studies that have evaluated vibriocidal, cholera toxin B subunit (CTB), and lipopolysaccharide (LPS) antibody levels following a clinical cholera case. Methods: Design: Systematic review and meta-analysis. We searched PubMed and Web of science for studies assessing antibodies against Vibrio cholerae in cohorts of patients with clinical cholera. Two authors independently extracted data and assessed the quality of included studies. Random effects models were used to pool antibody titers in adults and older children (aged >= 6 years). In sensitivity analysis, studies reporting data on young children (2-5 years) were included. Results: Nine studies met our inclusion criteria for systematic review and seven for meta-analysis. The pooled mean of vibriocidal antibody titers in adults and older children (aged >= 6 years) was 123 on day 2 post-symptom onset, which sharply increased on day 7 (pooled mean = 6956) and gradually waned to 2247 on day 30, 578 on day 90, and 177 on day 360. Anti-CTB IgA antibodies also peaked on day 7 (pooled mean = 49), followed by a rapid decrease on day 30 (pooled mean = 21), and further declined on day 90 (pooled mean = 10), after which it plateaued from day 180 (pooled mean = 8) to 360 (pooled mean = 6). Similarly, anti-CTB IgG antibodies peaked in early convalescence between days 7 (pooled mean = 65) and 30 (pooled mean = 69), then gradually waned on days 90 (pooled mean = 42) and 180 (pooled mean = 30) and returned to baseline on day 360 (pooled mean = 24). Anti-LPS IgA antibodies peaked on day 7 (pooled mean = 124), gradually declined on day 30 (pooled mean = 44), which persisted until day 360 (pooled mean = 10). Anti LPS IgG antibodies peaked on day 7 (pooled mean = 94). Thereafter, they decreased on day 30 (pooled mean = 85), and dropped further on days 90 (pooled mean = 51) and 180 (pooled mean = 47), and returned to baseline on day 360 (pooled mean = 32). Sensitivity analysis including data from young children (aged 2-5 years) showed very similar findings as in the primary analysis. Conclusions: This study confirms that serological antibody (vibriocidal, CTB, and LPS) titers return to baseline levels within 1 year following clinical cholera, i.e., before the protective immunity against subsequent cholera wanes. However, this decay should not be interpreted as waning immunity because immunity conferred by cholera against subsequent disease lasts 3-10 years. Our study provides evidence for surveillance strategies and future research on vaccines and also demonstrates the need for further studies to improve our understanding of immunity against cholera. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitraDebmalya en-aut-sei=Mitra en-aut-mei=Debmalya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cholera kn-keyword=cholera en-keyword=antibodies kn-keyword=antibodies en-keyword=vibriocidal kn-keyword=vibriocidal en-keyword=cholera toxin B kn-keyword=cholera toxin B en-keyword=lipopolysaccharide kn-keyword=lipopolysaccharide en-keyword=immunoglobulin kn-keyword=immunoglobulin en-keyword=immunity kn-keyword=immunity en-keyword=waning kn-keyword=waning END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=124 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Managements of sleep bruxism in adult: A systematic review en-subtitle= kn-subtitle= en-abstract= kn-abstract=This systematic review aimed to update the management of sleep bruxism (SB) in adults, as diagnosed using polysomnography (PSG) and/or electromyography (EMG). Management methods covered were oral appliance therapy (OAT) with stabilization splints, cognitive-behavioral therapy (CBT), biofeedback therapy (BFT), and pharmacological therapy. A comprehensive search was conducted on MEDLINE, Cochrane Library, and Web of Science up to October 1st, 2021. Reference list searches and hand searches were also performed by an external organization. Two reviewers for each therapy independently performed article selection, data extraction, and risk of bias assessment. The reviewers resolved any disagreements concerning the assortment of the articles by discussion. Finally, 11, 3, 14, and 22 articles were selected for each therapy. The results suggested that OAT tended to reduce the number of SB events, although there was no significant difference compared to other types of splints, that the potential benefits of CBT were not well supported, and that BFT, rabeprazole, clonazepam, clonidine, and botulinum toxin type A injection showed significant reductions in specific SB parameters, although several side effects were reported. It can be concluded that more methodologically rigorous randomized large-sample long-term follow-up clinical trials are needed to clarify the efficacy and safety of management for SB. en-copyright= kn-copyright= en-aut-name=MinakuchiHajime en-aut-sei=Minakuchi en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujisawaMasanori en-aut-sei=Fujisawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeYuka en-aut-sei=Abe en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IidaTakashi en-aut-sei=Iida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkiKyosuke en-aut-sei=Oki en-aut-mei=Kyosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkuraKazuo en-aut-sei=Okura en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanabeNorimasa en-aut-sei=Tanabe en-aut-mei=Norimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishiyamaAkira en-aut-sei=Nishiyama en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Division of Fixed Prosthodontics, Department of Restorative & Biomaterials Sciences, Meikai University School of Dentistry kn-affil= affil-num=3 en-affil=Department of Prosthodontics, School of Dentistry, Showa University kn-affil= affil-num=4 en-affil=Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo kn-affil= affil-num=5 en-affil=Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University kn-affil= affil-num=6 en-affil=Department of Stomatognathic Function and Occlusal Reconstruction, Institute of Biomedical Sciences, Tokushima University Graduate School kn-affil= affil-num=7 en-affil=Department of Prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical University kn-affil= affil-num=8 en-affil=General Dentistry, Comprehensive Patient Care, Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University kn-affil= en-keyword=Sleep bruxism kn-keyword=Sleep bruxism en-keyword=Management kn-keyword=Management en-keyword=Systematic review kn-keyword=Systematic review en-keyword=Oral appliances kn-keyword=Oral appliances en-keyword=Biofeedback therapy kn-keyword=Biofeedback therapy en-keyword=Cognitive-behavioral therapy kn-keyword=Cognitive-behavioral therapy en-keyword=Pharmacological therapy kn-keyword=Pharmacological therapy END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=9 article-no= start-page=5738 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Outbreaks in India, 2011-2020: A Systematic Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fecal contamination of water sources and open defecation have been linked to cholera outbreaks in India. However, a systematic review on the drivers responsible for these outbreaks has yet to be published. Here, we systematically review the published literature on cholera outbreaks in India between 2011 and 2020. We searched studies in English in three databases (MEDLINE, EMBASE, and Web of Science) and the Integrated Disease Surveillance Program that tracks cholera outbreaks throughout India. Two authors independently extracted data and assessed the quality of the included studies. Quantitative data on the modes of transmission reviewed in this study were assessed for any change over time between 2011-2015 and 2016-2020. Our search retrieved 10823 records initially, out of which 81 full-text studies were assessed for eligibility. Among these 81 studies, 20 were eligible for inclusion in this review. There were 565 reported outbreaks between 2011 and 2020 that led to 45,759 cases and 263 deaths. Outbreaks occurred throughout the year; however, they exploded with monsoons (June through September). In Tamil Nadu, a typical peak of cholera outbreaks was observed from December to January. Seventy-two percent (33,089/45,759) of outbreak-related cases were reported in five states, namely Maharashtra, West Bengal, Punjab, Karnataka, and Madhya Pradesh. Analysis of these outbreaks highlighted the main drivers of cholera including contaminated drinking water and food, inadequate sanitation and hygiene (including open defecation), and direct contact between households. The comparison between 2011-2015 and 2016-2020 showed a decreasing trend in the outbreaks that arose due to damaged water pipelines. Many Indians still struggle with open defecation, sanitation, and clean water access. These issues should be addressed critically. In addition, it is essential to interrupt cholera short-cycle transmission (mediated by households, stored drinking water and foodstuffs) during an outbreak. As cholera is associated with deprivation, socio-economic development is the only long-term solution. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cholera kn-keyword=cholera en-keyword=outbreak kn-keyword=outbreak en-keyword=water supply kn-keyword=water supply en-keyword=open defecation kn-keyword=open defecation en-keyword=sewage kn-keyword=sewage en-keyword=household kn-keyword=household en-keyword=food kn-keyword=food en-keyword=close contact kn-keyword=close contact en-keyword=behavioral changes kn-keyword=behavioral changes en-keyword=India kn-keyword=India END start-ver=1.4 cd-journal=joma no-vol=2021 cd-vols= no-issue= article-no= start-page=8883946 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Accuracy of Deep Learning Algorithms for the Diagnosis of Retinopathy of Prematurity by Fundus Images: A Systematic Review and Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background. Retinopathy of prematurity (ROP) occurs in preterm infants and may contribute to blindness. Deep learning (DL) models have been used for ophthalmologic diagnoses. We performed a systematic review and meta-analysis of published evidence to summarize and evaluate the diagnostic accuracy of DL algorithms for ROP by fundus images.
Methods. We searched PubMed, EMBASE, Web of Science, and Institute of Electrical and Electronics Engineers Xplore Digital Library on June 13, 2021, for studies using a DL algorithm to distinguish individuals with ROP of different grades, which provided accuracy measurements. ,e pooled sensitivity and specificity values and the area under the curve (AUC) of summary receiver operating characteristics curves (SROC) summarized overall test performance. ,e performances in validation and test datasets were assessed together and separately. Subgroup analyses were conducted between the definition and grades of ROP. ,reshold and nonthreshold effects were tested to assess biases and evaluate accuracy factors associated with DL models.
Results. Nine studies with fifteen classifiers were included in our meta-analysis. A total of 521,586 objects were applied to DL models. For combined validation and test datasets in each study, the pooled sensitivity and specificity were 0.953 (95% confidence intervals (CI): 0.946?0.959) and 0.975 (0.973?0.977), respectively, and the AUC was 0.984 (0.978?0.989). For the validation dataset and test dataset, the AUC was 0.977 (0.968?0.986) and 0.987 (0.982?0.992), respectively. In the subgroup analysis of ROP vs. normal and differentiation of two ROP grades, the AUC was 0.990 (0.944?0.994) and 0.982 (0.964?0.999), respectively.
Conclusions. Our study shows that DL models can play an essential role in detecting and grading ROP with high sensitivity, specificity, and repeatability. ,e application of a DL-based automated system may improve ROP screening and diagnosis in the future. en-copyright= kn-copyright= en-aut-name=ZhangJingjing en-aut-sei=Zhang en-aut-mei=Jingjing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiuYangyang en-aut-sei=Liu en-aut-mei=Yangyang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Regenerative and Reconstructive Medicine (Ophthalmology), Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama University kn-affil= affil-num=4 en-affil=Department of Regenerative and Reconstructive Medicine (Ophthalmology), Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=3 article-no= start-page=180 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Catalog of prognostic tissue-based biomarkers in patients treated with neoadjuvant systemic therapy for urothelial carcinoma of the bladder: a systematic review en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE
The present systematic review aimed to identify prognostic values of tissue-based biomarkers in patients treated with neoadjuvant systemic therapy (NAST), including chemotherapy (NAC) and checkpoint inhibitors (NAI) for urothelial carcinoma of the bladder (UCB).
MATERIAL AND METHODS
The PubMed, Web of Science, and Scopus databases were searched in August 2020 according to the PRISMA statement. Studies were deemed eligible if they compared oncologic or pathologic outcomes in patients treated with NAST for UCB with and without detected pretreatment tissue-based biomarkers.
RESULTS
Overall, 44 studies met our eligibility criteria. Twenty-three studies used immunohistochemistry (IHC), 19 ? gene expression analysis, three - quantitative polymerase chain reaction (QT PCR), and two ? next-generation sequencing (NGS). According to the currently available literature, predictive IHC-assessed biomarkers, such as receptor tyrosine kinases and DNA repair pathway alterations, do not seem to convincingly improve our prediction of pathologic response and oncologic outcomes after NAC. Luminal and basal tumor subtypes based on gene expression analysis showed better NAC response, while claudin-low and luminal-infiltrated tumor subtypes did not. In terms of NAI, PD-L1 seems to maintain value as a predictive biomarker, while the utility of both tumor mutational burden and molecular subtypes remains controversial. Specific genomic alterations in DNA repair genes have been shown to provide significant predictive value in patient treated with NAC. QT PCR quantification of specific genes selected through microarray analysis seems to classify cases regarding their NAC response.
CONCLUSION
We believe that the present systematic review may offer a robust framework that will enable the testing and validation of predictive biomarkers in future prospective clinical trials. NGS has expanded the discovery of molecular markers that are reflective of the mechanisms of the NAST response. en-copyright= kn-copyright= en-aut-name=LaukhtinaEkaterina en-aut-sei=Laukhtina en-aut-mei=Ekaterina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=PradereBenjamin en-aut-sei=Pradere en-aut-mei=Benjamin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoriKeiichiro en-aut-sei=Mori en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SchuettfortVictor M. en-aut-sei=Schuettfort en-aut-mei=Victor M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=QuhalFahad en-aut-sei=Quhal en-aut-mei=Fahad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MostafaeiHadi en-aut-sei=Mostafaei en-aut-mei=Hadi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=Sari MotlanghReza en-aut-sei=Sari Motlangh en-aut-mei=Reza kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GrossmannNico C. en-aut-sei=Grossmann en-aut-mei=Nico C. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MoschiniMarco en-aut-sei=Moschini en-aut-mei=Marco kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=EnikeevDmitry en-aut-sei=Enikeev en-aut-mei=Dmitry kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ShariatShahrokh F. en-aut-sei=Shariat en-aut-mei=Shahrokh F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=2 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=3 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=4 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=5 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=6 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=7 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= affil-num=10 en-affil=Department of Urology, Luzerner Kantonsspital kn-affil= affil-num=11 en-affil=Institute for Urology and Reproductive Health, Sechenov University, kn-affil= affil-num=12 en-affil=Department of Urology, Comprehensive Cancer Center, Medical University of Vienna kn-affil= en-keyword=Biomarkers kn-keyword=Biomarkers en-keyword=UCB kn-keyword=UCB en-keyword=bladder cancer kn-keyword=bladder cancer en-keyword=Neoadjuvant systemic therapy kn-keyword=Neoadjuvant systemic therapy en-keyword=NAC kn-keyword=NAC en-keyword=systematic review kn-keyword=systematic review END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=211 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191209 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prognostic significance of the controlling nutritional status (CONUT) score in patients undergoing hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: The clinical value of the controlling nutritional status (CONUT) score in hepatocellular carcinoma (HCC) has increased. The aim of this meta-analysis was to systematically review the association between the CONUT score and outcomes in patients undergoing hepatectomy for HCC.
Methods: Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar were systematically searched. Random effects meta-analyses were conducted to examine the prognostic value of the CONUT score in HCC patients.
Results: A total of five studies including 4679 patients were found to be eligible and analyzed in the meta-analysis. The CONUT score was significantly associated with overall survival (HR 1.78, 95%CI = 1.20-2.64, P = 0.004, I-2 = 79%), recurrence-free survival (HR 1.34, 95%CI = 1.17-1.53, P < 0.001, I-2 = 16%) and postoperative major complications (OR 1.85, 95%CI: 1.19-2.87, P = 0.006, I-2 = 72%) in HCC patients. Moreover, the CONUT score was associated with the Child-Pugh classification, liver cirrhosis, ICGR15, and tumor differentiation. However, it was not associated with tumor size, tumor number, and microvascular invasion.
Conclusions: The CONUT score is an independent prognostic indicator of the prognosis and is associated with postoperative major complications and hepatic functional reserve in HCC patients. en-copyright= kn-copyright= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DomagalaPiotr en-aut-sei=Domagala en-aut-mei=Piotr kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=PolakWojciech G. en-aut-sei=Polak en-aut-mei=Wojciech G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=BuettnerStefan en-aut-sei=Buettner en-aut-mei=Stefan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IjzermansJan N. M. en-aut-sei=Ijzermans en-aut-mei=Jan N. M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam kn-affil= affil-num=3 en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam kn-affil= affil-num=4 en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam kn-affil= affil-num=5 en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam kn-affil= en-keyword=Controlling nutritional status (CONUT) score kn-keyword=Controlling nutritional status (CONUT) score en-keyword=Hepatocellular carcinoma kn-keyword=Hepatocellular carcinoma en-keyword=Outcome kn-keyword=Outcome en-keyword=Meta-analysis kn-keyword=Meta-analysis END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=5 article-no= start-page=722 end-page=734 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190713 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Disease Management of Primary Urethral Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Context: Primary urethral cancer (PUC) is a rare cancer entity. Owing to the low incidence of this malignancy, the main body of literature consists mainly of case reports, making evidence-based management recommendations difficult.
Objective: To review reported disease management strategies of PUC and their impact on oncological outcomes.
Evidence acquisition: A systematic research was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement using Medline, Scopus, and Web of Science, to find studies of the past 10yr including ?20 patients, and investigating treatment strategies and their impact on outcomes of the three most frequent histologies: urothelial carcinoma, adenocarcinoma, and squamous cell carcinoma. Evidence synthesis: In localized PUC, penis-sparing surgery can be performed in males, while in females, complete urethrectomy with surrounding tissue is advised to minimize recurrence due to positive margins. Radiotherapy (RT) has worse survival and recurrence rates, as well as more adverse effects, than surgery, limiting its use in genital-preserving therapy. Locally advanced PUC should be treated with multimodal therapy, as monotherapies result in inferior recurrence and survival rates. Extent of surgery is still undecided, favoring radical cyst(oprostat)ectomy with total urethrectomy (RCU). Lymph node involvement is a predictor of survival, highlighting the role of lymph node dissection for disease control and staging. RT can improve survival in combination with surgery and/or chemotherapy (CHT). Neoadjuvant platinum-based CHT can improve overall and recurrence-free survival. At recurrence, salvage therapy with surgery and/or CHT can improve survival. Superficial urothelial carcinoma of the prostatic urethra can be treated with transurethral resection. Stromal invasion often features concomitant bladder cancer with a poor prognosis and requires RCU with or without systemic preoperative CHT.
Conclusions: PUC is a rare malignancy with an often poor natural course, requiring a stage- and gender-specific risk-based treatment strategy. The role of systematic perioperative CHT and the extent of surgery are becoming more important.
Patient summary: In this review, we looked at the treatment options for primary urethral cancer. We found that while an organ-confined disease can be managed with local resection, growth beyond the organ border makes a combination of different treatment modalities, such as surgery and systematic chemotherapy, necessary to improve outcomes. en-copyright= kn-copyright= en-aut-name=JanischFlorian en-aut-sei=Janisch en-aut-mei=Florian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbufarajMohammad en-aut-sei=Abufaraj en-aut-mei=Mohammad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FajkovicHarun en-aut-sei=Fajkovic en-aut-mei=Harun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KimuraShoji en-aut-sei=Kimura en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NyiradyPeter en-aut-sei=Nyirady en-aut-mei=Peter kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=RinkMichael en-aut-sei=Rink en-aut-mei=Michael kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShariatShahrokh F. en-aut-sei=Shariat en-aut-mei=Shahrokh F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Urology, Medical University of Vienna kn-affil= affil-num=2 en-affil=Department of Urology, Medical University of Vienna kn-affil= affil-num=3 en-affil=Department of Urology, Medical University of Vienna kn-affil= affil-num=4 en-affil=Department of Urology, Medical University of Vienna kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Urology, Semmelweis University kn-affil= affil-num=7 en-affil=Department of Urology, University Medical Center Hamburg-Eppendorf kn-affil= affil-num=8 en-affil=Department of Urology, Medical University of Vienna kn-affil= en-keyword=Disease management kn-keyword=Disease management en-keyword=Primary urethral carcinoma kn-keyword=Primary urethral carcinoma en-keyword=Prognosis kn-keyword=Prognosis en-keyword=Therapy kn-keyword=Therapy en-keyword=Treatment kn-keyword=Treatment END start-ver=1.4 cd-journal=joma no-vol=552 cd-vols= no-issue=3 article-no= start-page=292 end-page=328 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Design and performance of the ABCD3TA ASIC for readout of silicon strip detectors in the ATLAS semiconductor tracke en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The ABCD3TA is a 128-channel ASIC with binary architecture for the readout of silicon strip particle detectors in the Semiconductor Tracker of the ATLAS experiment at the Large Hadron Collider (LHC). The chip comprises fast front-end and amplitude discriminator circuits using bipolar devices, a binary pipeline for first level trigger latency, a second level derandomising buffer and data compression circuitry based on CMOS devices. It has been designed and fabricated in a BiCMOS radiation resistant process. Extensive testing of the ABCD3TA chips assembled into detector modules show that the design meets the specifications and maintains the required performance after irradiation up to a total ionising dose of 10 Mrad and a 1-MeV neutron equivalent fluence of 2~1014 n/cm2, corresponding to 10 years of operation of the LHC at its design luminosity. Wafer screening and quality assurance procedures have been developed and implemented in large volume production to ensure that the chips assembled into modules meet the rigorous acceptance criteria.

en-copyright= kn-copyright= en-aut-name=CampabadalF en-aut-sei=Campabadal en-aut-mei=F kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FletaC en-aut-sei=Fleta en-aut-mei=C kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KeyM en-aut-sei=Key en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LozanoM en-aut-sei=Lozano en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MartinezC en-aut-sei=Martinez en-aut-mei=C kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PellegriniG en-aut-sei=Pellegrini en-aut-mei=G kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=RafiJ M en-aut-sei=Rafi en-aut-mei=J M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UllanM en-aut-sei=Ullan en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=JohansenL G en-aut-sei=Johansen en-aut-mei=L G kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MohnB en-aut-sei=Mohn en-aut-mei=B kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OyeO en-aut-sei=Oye en-aut-mei=O kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SolbergA O en-aut-sei=Solberg en-aut-mei=A O kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=StuguB en-aut-sei=Stugu en-aut-mei=B kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=CiocioA en-aut-sei=Ciocio en-aut-mei=A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=ElyR en-aut-sei=Ely en-aut-mei=R kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=FadeyevV en-aut-sei=Fadeyev en-aut-mei=V kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=GilchrieseM en-aut-sei=Gilchriese en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=HaberC en-aut-sei=Haber en-aut-mei=C 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en-aut-sei=Kundu en-aut-mei=N kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=89 ORCID= en-aut-name=NickersonR B en-aut-sei=Nickerson en-aut-mei=R B kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=90 ORCID= en-aut-name=WeidbergA en-aut-sei=Weidberg en-aut-mei=A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=91 ORCID= en-aut-name=BohmJ en-aut-sei=Bohm en-aut-mei=J kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=92 ORCID= en-aut-name=MikestikovaM en-aut-sei=Mikestikova en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=93 ORCID= en-aut-name=StastnyJ en-aut-sei=Stastny en-aut-mei=J kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=94 ORCID= en-aut-name=BroklovaZ en-aut-sei=Broklova en-aut-mei=Z kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=95 ORCID= en-aut-name=BrozJ en-aut-sei=Broz en-aut-mei=J kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=96 ORCID= en-aut-name=DolezalZ en-aut-sei=Dolezal en-aut-mei=Z kn-aut-name= kn-aut-sei= kn-aut-mei= 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kn-affil=Instituto de Microelectronica de Barcelona, IMB-CNM, CSIC, Barcelona, Spain affil-num=9 en-affil= kn-affil=University of Bergen, Bergen, Norway affil-num=10 en-affil= kn-affil=University of Bergen, Bergen, Norway affil-num=11 en-affil= kn-affil=University of Bergen, Bergen, Norway affil-num=12 en-affil= kn-affil=University of Bergen, Bergen, Norway affil-num=13 en-affil= kn-affil=University of Bergen, Bergen, Norway affil-num=14 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=15 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=16 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=17 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=18 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=19 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=20 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=21 en-affil= kn-affil=Lawrence Berkeley Laboratory and University of California, Berkeley, California, USA affil-num=22 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=23 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=24 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=25 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=26 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=27 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=28 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=29 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=30 en-affil= kn-affil=School of Physics and Astronomy, The University of Birmingham, Birmingham, UK affil-num=31 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=32 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=33 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=34 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=35 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=36 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=37 en-affil= kn-affil=Cavendish Laboratory, Cambridge University, Cambridge, UK affil-num=38 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=39 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=40 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=41 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=42 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=43 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=44 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=45 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=46 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=47 en-affil= kn-affil=CERN, European Organization for Nuclear Research, Geneva, Switzerland affil-num=48 en-affil= kn-affil=Faculty Physics and Applied Computer Science, AGH University Science Technology, Krakow, Poland affil-num=49 en-affil= kn-affil=Faculty Physics and Applied Computer Science, AGH University Science Technology, Krakow, Poland affil-num=50 en-affil= kn-affil=Faculty Physics and Applied Computer Science, AGH University Science Technology, Krakow, Poland affil-num=51 en-affil= kn-affil=Faculty Physics and Applied Computer Science, AGH University Science Technology, Krakow, Poland affil-num=52 en-affil= kn-affil=Faculty Physics and Applied Computer Science, AGH University Science Technology, Krakow, Poland affil-num=53 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=54 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=55 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=56 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=57 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=58 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=59 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=60 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=61 en-affil= kn-affil=The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland affil-num=62 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=63 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=64 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=65 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=66 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=67 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=68 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=69 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=70 en-affil= kn-affil=Max-Planck-Institut fur Physik, Munchen, Germany affil-num=71 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=72 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=73 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=74 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=75 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=76 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=77 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=78 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=79 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=80 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=81 en-affil= kn-affil=NIKHEF, Amsterdam, The Netherlands affil-num=82 en-affil= kn-affil=Physics Department, Okayama University, Okayama, Japan affil-num=83 en-affil= kn-affil=Physics Department, Okayama University, Okayama, Japan affil-num=84 en-affil= kn-affil=University of Oslo, Oslo, Norway affil-num=85 en-affil= kn-affil=University of Oslo, Oslo, Norway affil-num=86 en-affil= kn-affil=University of Oslo, Oslo, Norway affil-num=87 en-affil= kn-affil=University of Oslo, Oslo, Norway affil-num=88 en-affil= kn-affil=University of Oslo, Oslo, Norway affil-num=89 en-affil= kn-affil=Department of Physics, Oxford University, Oxford, UK affil-num=90 en-affil= kn-affil=Department of Physics, Oxford University, Oxford, UK affil-num=91 en-affil= kn-affil=Department of Physics, Oxford University, Oxford, UK affil-num=92 en-affil= kn-affil=Academy of Sciences of the Czech Republic (ASCR), Prague, Czech Republic affil-num=93 en-affil= kn-affil=Academy of Sciences of the Czech Republic (ASCR), Prague, Czech Republic affil-num=94 en-affil= kn-affil=Academy of Sciences of the Czech Republic (ASCR), Prague, Czech Republic affil-num=95 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=96 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=97 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=98 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=99 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=100 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=101 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=102 en-affil= kn-affil=Charles University, Prague, Czech Republic affil-num=103 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=104 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=105 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=106 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=107 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=108 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=109 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=110 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=111 en-affil= kn-affil=Czech Technical University, Prague, Czech Republic affil-num=112 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=113 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=114 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=115 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=116 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=117 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=118 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=119 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=120 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=121 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=122 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=123 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=124 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=125 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=126 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=127 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=128 en-affil= kn-affil=Rutherford Appleton Laboratory, Chilton, Didcot, UK affil-num=129 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=130 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=131 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=132 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=133 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=134 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=135 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=136 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=137 en-affil= kn-affil=Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California, USA affil-num=138 en-affil= kn-affil=Institute of Physics, University of Tsukuba, Tsukuba, Japan affil-num=139 en-affil= kn-affil=Institute of Physics, University of Tsukuba, Tsukuba, Japan affil-num=140 en-affil= kn-affil=Institute of Physics, University of Tsukuba, Tsukuba, Japan affil-num=141 en-affil= kn-affil=Department of Radiation Sciences, Uppsala Universit, Uppsala, Sweden affil-num=142 en-affil= kn-affil=Department of Radiation Sciences, Uppsala Universit, Uppsala, Sweden affil-num=143 en-affil= kn-affil=Department of Radiation Sciences, Uppsala Universit, Uppsala, Sweden affil-num=144 en-affil= kn-affil=Department of Radiation Sciences, Uppsala Universit, Uppsala, Sweden affil-num=145 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=146 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=147 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=148 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=149 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=150 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=151 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=152 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=153 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=154 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=155 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=156 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=157 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain affil-num=158 en-affil= kn-affil=Instituto de Fisica Corpuscular (IFIC), Universidad de Valencia-CSIC, Valencia, Spain en-keyword=Front-end electronics kn-keyword=Front-end electronics en-keyword=Binary readout kn-keyword=Binary readout en-keyword=Silicon strip detectors kn-keyword=Silicon strip detectors en-keyword=Tracking detectors kn-keyword=Tracking detectors en-keyword=Radiation damage kn-keyword=Radiation damage END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=3 article-no= start-page=252 end-page=256 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20049 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessment of MRI and dynamic contrast-enhanced MRI in the differential diagnosis of adenomatoid odontogenic tumor en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts, and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our 3 cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI, and enhancement of only the solid portion on CE-T1WI although non of the sequences included SI of calcifications. The contrast index curves in the 3 cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations.

en-copyright= kn-copyright= en-aut-name=AsaumiJun-ichi en-aut-sei=Asaumi en-aut-mei=Jun-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YanagiYoshinobu en-aut-sei=Yanagi en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonouchiHironobu en-aut-sei=Konouchi en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HisatomiMiki en-aut-sei=Hisatomi en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuzakiHidenobu en-aut-sei=Matsuzaki en-aut-mei=Hidenobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShigeharaHiroshi en-aut-sei=Shigehara en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KishiKanji en-aut-sei=Kishi en-aut-mei=Kanji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=AOT kn-keyword=AOT en-keyword=odontogenic tumor kn-keyword=odontogenic tumor en-keyword=odontogenic cyst kn-keyword=odontogenic cyst en-keyword=MRI kn-keyword=MRI en-keyword=DCE-MRI kn-keyword=DCE-MRI END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1111 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evidence for new beta 1-3 galactosyltransferase activity involved in biosynthesis of unusual N-glycan harboring T-antigen in Apis mellifera en-subtitle= kn-subtitle= en-abstract= kn-abstract=In a previous study (Y. Kimura et al., Biosci. Biotechnol Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen-Friedenreich antigen (Ga1 beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc(2)GlcNAc(2)Man(3)-GlcNAc(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N-glycan containing a tumor related antigen in the hypopharyngeal gland. en-copyright= kn-copyright= en-aut-name=KimuraYoshinobu en-aut-sei=Kimura en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamuraSho en-aut-sei=Sakamura en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UshijimaTakayuki en-aut-sei=Ushijima en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HamaYoichiro en-aut-sei=Hama en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KajiuraHiroyuki en-aut-sei=Kajiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiyamaKazuhito en-aut-sei=Fujiyama en-aut-mei=Kazuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkiharaKiyoshi en-aut-sei=Okihara en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HashimotoKen en-aut-sei=Hashimoto en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SugimotoHiroyuki en-aut-sei=Sugimoto en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaHideo en-aut-sei=Yamada en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Department of Applied Biological Sciences, Faculty of Agriculture, Saga University affil-num=5 en-affil= kn-affil=The International Center for Biotechnology, Osaka University affil-num=6 en-affil= kn-affil=The International Center for Biotechnology, Osaka University affil-num=7 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=8 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=9 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=10 en-affil= kn-affil=Yamada Apiculture Center, Inc. en-keyword=royal jelly glycoprotein; N-glycan kn-keyword=royal jelly glycoprotein; N-glycan en-keyword=Thomsen-Friedenreich antigen (Gal beta 1-3GalNAc) kn-keyword=Thomsen-Friedenreich antigen (Gal beta 1-3GalNAc) en-keyword=beta 1-3 galactosyltransferase kn-keyword=beta 1-3 galactosyltransferase en-keyword=Apis mellifera kn-keyword=Apis mellifera END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=1530 end-page=1536 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20076 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serine racemases from barley, Hordeum vulgare L., and other plant species represent a distinct eukaryotic group: gene cloning and recombinant protein characterization en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Several D-amino acids have been identified in plants. However, the biosynthetic pathway to them is unclear. In this study, we cloned and sequenced a cDNA encoding a serine racemase from barley which contained an open reading frame encoding 337 amino acid residues. The deduced amino acid sequence showed significant identity to plant and mammalian serine racemases and contained conserved pyridoxal 5-phosphate (PLP)-binding lysine and PLP?interacting amino acid residues. The purified gene product catalyzed not only racemization of serine but also dehydration of serine to pyruvate. The enzyme requires PLP and divalent cations such as Ca2+, Mg2+, or Mn2+, but not ATP, whereas mammalian serine racemase activity is increased by ATP. In addition to the results regarding the effect of ATP on enzyme activity and the phylogenetic analysis of eukaryotic serine racemases, the antiserum against Arabidopsis serine racemase did not form a precipitate with barley and rice serine racemases. This suggests that plant serine racemases represent a distinct group in the eukaryotic serine racemase family and can be clustered into monocot and dicot types.

en-copyright= kn-copyright= en-aut-name=FujitaniYoshiyuki en-aut-sei=Fujitani en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HoriuchiTerumi en-aut-sei=Horiuchi en-aut-mei=Terumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItoKazutoshi en-aut-sei=Ito en-aut-mei=Kazutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugimotoManabu en-aut-sei=Sugimoto en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Plant Bioengineering Research Laboratories, Sapporo Breweries Ltd. affil-num=4 en-affil= kn-affil=Okayama University en-keyword=Hordeum vulgare L. kn-keyword=Hordeum vulgare L. en-keyword=Oryza sativa kn-keyword=Oryza sativa en-keyword=Gramineae kn-keyword=Gramineae en-keyword=Pyridoxal 5-phosphate kn-keyword=Pyridoxal 5-phosphate en-keyword=Serine racemase kn-keyword=Serine racemase en-keyword=Serine dehydratase kn-keyword=Serine dehydratase en-keyword=d-Amino acid kn-keyword=d-Amino acid END start-ver=1.4 cd-journal=joma no-vol=279 cd-vols= no-issue=3 article-no= start-page=303 end-page=312 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Modulation of defense signal transduction by flagellin-induced WRKY41 transcription factor in Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Flagellin, a component of the flagellar filament of Pseudomonas syringae pv. tabaci 6605 (Pta), induces hypersensitive reaction in its non-host Arabidopsis thaliana. We identified the WRKY41 gene, which belongs to a multigene family encoding WRKY plant-specific transcription factors, as one of the flagellin-inducible genes in A. thaliana. Expression of WRKY41 is induced by inoculation with the incompatible pathogen P. syringae pv. tomato DC3000 (Pto) possessing AvrRpt2 and the non-host pathogens Pta within 6-h after inoculation, but not by inoculation with the compatible Pto. Expression of WRKY41 was also induced by inoculation of A. thaliana with an hrp-type three secretion system (T3SS)-defective mutant of Pto, indicating that effectors produced by T3SS in the Pto wild-type suppress the activation of WRKY41. Arabidopsis overexpressing WRKY41 showed enhanced resistance to the Pto wild-type but increased susceptibility to Erwinia carotovora EC1. WRKY41-overexpressing Arabidopsis constitutively expresses the PR5 gene, but suppresses the methyl jasmonate-induced PDF1.2 gene expression. These results demonstrate that WRKY41 may be a key regulator in the cross talk of salicylic acid and jasmonic acid pathways.

en-copyright= kn-copyright= en-aut-name=HigashiKuniaki en-aut-sei=Higashi en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshigaYasuhiro en-aut-sei=Ishiga en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InagakiYoshishige en-aut-sei=Inagaki en-aut-mei=Yoshishige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=flagellin kn-keyword=flagellin en-keyword=flg22 kn-keyword=flg22 en-keyword=FLS2 kn-keyword=FLS2 en-keyword=MAMP signaling pathway kn-keyword=MAMP signaling pathway en-keyword=WRKY41 kn-keyword=WRKY41 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1086 end-page=1089 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Three antinematodal diterpenes from Euphorbia kansui en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three compounds, 20-O-acetyl-[3-O-(2'E,4'Z)-deca-dienoyl]-ingenol (1), 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol (2) and 3-O-(2'E,4'Z)-decadienoylingenol (3), were isolated from Euphorbia kansui under the bioassay-guided method. Each compound showed the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 mu g/cotton ball. en-copyright= kn-copyright= en-aut-name=ShiJian-Xiao en-aut-sei=Shi en-aut-mei=Jian-Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiZhi-Xuan en-aut-sei=Li en-aut-mei=Zhi-Xuan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NitodaTeruhiko en-aut-sei=Nitoda en-aut-mei=Teruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanzakiHiroshi en-aut-sei=Kanzaki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawazuKazuyoshi en-aut-sei=Kawazu en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=College of Life Science, Northwest University affil-num=2 en-affil= kn-affil=College of Life Science, Northwest University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=6 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=7 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=8 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University en-keyword=antinematodal activity kn-keyword=antinematodal activity en-keyword=Bursaphelenchus xylophilus kn-keyword=Bursaphelenchus xylophilus en-keyword=diterpenoid kn-keyword=diterpenoid en-keyword=ingenane kn-keyword=ingenane en-keyword=Euphorbia kansui kn-keyword=Euphorbia kansui END start-ver=1.4 cd-journal=joma no-vol=272 cd-vols= no-issue=1 article-no= start-page=116 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20048 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Isolation of a transcriptionally active element of high copy number retrotransposons in sweetpotato genome en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Many plant retrotransposons have been characterized, but only three families (Tnt1, Tto1 and Tos17) have been demonstrated to be transpositionally competent. We followed a novel approach that enabled us to identify an active element of the Ty1-copia retrotransposon family with estimated 400 copies in the sweetpotato genome. DNA sequences of Ty1 -copia reverse transcriptase (RTase) from the sweetpotato genome were analyzed, and a group of retrotransposon copies probably formed by recent transposition events was further analyzed. 3fRACE on callus cDNA amplified transcripts containing long terminal repeats (LTR) of this group. The sequence -specific amplification polymorphism (S-SAP) patterns of the LTR sequence in the genomic DNA were compared between a normal plant and callus lines derived from it. A callus -specific S-SAP product was found into which the retrotransposon detected by the 3fRACE had been transposed apparently during cell culture. We conclude that our approach provides an effective way to identify active elements of retrotransposons with high copy numbers.

en-copyright= kn-copyright= en-aut-name=TaharaMakoto en-aut-sei=Tahara en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AokiTakahiro en-aut-sei=Aoki en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukaShinya en-aut-sei=Suzuka en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashitaHiroki en-aut-sei=Yamashita en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaMasaru en-aut-sei=Tanaka en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsunagaSachi en-aut-sei=Matsunaga en-aut-mei=Sachi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KokumaiShuhei en-aut-sei=Kokumai en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=JEOL Limited affil-num=3 en-affil= kn-affil=SK Foods Company, Limited affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=National Agricultural Research Center affil-num=6 en-affil= kn-affil=Kabaya Foods Corporation affil-num=7 en-affil= kn-affil=Okayama University en-keyword=retrotransposon kn-keyword=retrotransposon en-keyword=Ipomoea batatas kn-keyword=Ipomoea batatas en-keyword=S-SAP kn-keyword=S-SAP en-keyword=transposition kn-keyword=transposition END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1-2 article-no= start-page=59 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alternative methods to evaluate the protective ability of sunscreen against photo-genotoxicity en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Numerous epidemiological investigations show that sunlight is carcinogenic to humans and that the use of sunscreen may be effective in decreasing the risk of skin cancer. The biological activity of a sunscreen is evaluated by its ability to protect human skin from erythema as represented by a Sun Protection Factor (SPF). We propose that the sunscreen's protective effect against sunlight-induced genotoxicity, including mutation, should also be taken into account. In this study we examined the protective ability of sunscreens against natural sunlight and UV-induced genotoxicity in Drosophila somatic cells. We prepared three kinds of sunscreen samples, each with an SPF value of 20, 40 or 60 and compared their protective activities with commercial sunscreens. When a sunscreen of SPF 20, 40 or 60 was pasted on the plastic cover of a petri dish in which Drosophila larvae were exposed to the sun or UV lamps, genotoxicity decreased as the SPF of the sunscreen increased, relative to levels of genotoxicity observed in samples without sunscreen. However, the protective abilities of sunscreens were unexpectedly not so different from each other. To reveal the relationship between the protective activity of sunscreen and the wavelength of light with which larvae were irradiated through the sunscreen, we measured the transmittance of light through the petri dish cover on which the sunscreen was pasted. Effective protection was demonstrated by removing components of light whose wavelengths were below 315 nm. We suggest, that the measurement of anti-genotoxic activity and the determination of the wavelengths of light transmitted through the sunscreen should be an alternative method for evaluating the effectiveness of a sunscreen.

en-copyright= kn-copyright= en-aut-name=ToyoshimaMegumi en-aut-sei=Toyoshima en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HosodaKanako en-aut-sei=Hosoda en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanamuraMiho en-aut-sei=Hanamura en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiHiroshi en-aut-sei=Kobayashi en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NegishiTomoe en-aut-sei=Negishi en-aut-mei=Tomoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Shiseido Research Center affil-num=6 en-affil= kn-affil=Okayama University en-keyword=sunscreen kn-keyword=sunscreen en-keyword=sunlight kn-keyword=sunlight en-keyword=UVB kn-keyword=UVB en-keyword=somatic cell mutation kn-keyword=somatic cell mutation en-keyword=genotoxicity kn-keyword=genotoxicity en-keyword=transmittance kn-keyword=transmittance en-keyword=Drosophila melanogaster kn-keyword=Drosophila melanogaster END start-ver=1.4 cd-journal=joma no-vol=143 cd-vols= no-issue=4 article-no= start-page=467 end-page=473 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080626 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Selenite Assimilation into Formate Dehydrogenase H Depends on Thioredoxin Reductase in Escherichia coli en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Escherichia coli growing under anaerobic conditions produce H-2 and CO2 by the enzymatic cleavage of formate that is produced from pyruvate at the end of glycolysis. Selenium is an integral part of formate dehydrogenase H (FDHH), which catalyses the first step in the formate hydrogen lyase (FHL) system. The genes of FHL system are transcribed only under anaerobic conditions, in the presence of a sigma(54)-dependent transcriptional activator Fh1A that binds formate as an effector molecule. Although the formate addition to the nutrient media has been an established procedure for inducing high FDHH activity, we have identified a low-salt nutrient medium containing <0.1% NaCl enabled constitutive, high expression of FDHH even without formate and D-glucose added to the medium. The novel conditions allowed us to study the effects of disrupting genes like trxB (thioredoxin reductase) or gor (glutathione reductase) on the production of FDHH activity and also reductive assimilation of selenite (SeO32-) into the selenoprotein. Despite the widely accepted hypothesis that selenite is reduced by glutathione reductase-dependent system, it was demonstrated that trxB gene was essential for FDHH production and for labelling the FDHH polypeptide with Se-75-selenite. Our present study reports for the first time the physiological involvement of thioredoxin reductase in the reductive assimilation of selenite in E. coli.

en-copyright= kn-copyright= en-aut-name=TakahataMuneaki en-aut-sei=Takahata en-aut-mei=Muneaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TamuraTakashi en-aut-sei=Tamura en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeKatsumasa en-aut-sei=Abe en-aut-mei=Katsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiharaHisaaki en-aut-sei=Mihara en-aut-mei=Hisaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurokawaSuguru en-aut-sei=Kurokawa en-aut-mei=Suguru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamotoYoshihiro en-aut-sei=Yamamoto en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanoRyuhei en-aut-sei=Nakano en-aut-mei=Ryuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EsakiNobuyoshi en-aut-sei=Esaki en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=InagakiKenji en-aut-sei=Inagaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=4 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=5 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=6 en-affil= kn-affil=Department of Genetics, Hyogo College of Medicine affil-num=7 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Department of Genetics, Hyogo College of Medicine affil-num=9 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=formate dehydrogenase H kn-keyword=formate dehydrogenase H en-keyword=selenite assimilation kn-keyword=selenite assimilation en-keyword=thioredoxin reductase kn-keyword=thioredoxin reductase END start-ver=1.4 cd-journal=joma no-vol=579 cd-vols= no-issue=19 article-no= start-page=4069 end-page=4075 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=The EGF (epidermal growth factor) receptor-tyrosine kinase inhibitor ZD1839 (Gefitinib, 'Iressa') blocks the cell signaling pathways involved in cell proliferation, survival, and angiogenesis in various cancer cells. TNF-related death apoptosis inducing ligand (TRAIL) acts as an anticancer agent. We investigated the antitumor effects of ZD1839 alone or in combination with TRAIL against human esophageal squamous cell cancer (ESCC) lines. Although all ESCC cells expressed EGF receptor at a protein level, the effect of ZD1839 on cell growth did not correlate with the level of EGFR expression and phosphorylation of EGF receptor protein in ESCC lines. ZD1839 caused a dose-dependent growth arrest at G0?G1 phase associated with increased p27 expression. As TE8 cells are resistant to TRAIL, we tested whether ZD1839 combined with TRAIL induced apoptosis of TE8 cells via the inhibition of EGF receptor signaling by ZD1839. ZD1839 inhibited the phosphorylation of Akt, and enhanced TRAIL-induced apoptosis via activation of caspase-3 and caspase-9, and inactivation of Bcl-xL. Our results indicated that ZD1839 has anti-cancer properties against human esophageal cancer cells. ZD1839 also augmented the anti-cancer activity of TRAIL, even in TRAIL-resistant tumors. These results suggest that treatment with ZD1839 and TRAIL may have potential in the treatment of ESCC patients. en-copyright= kn-copyright= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeTakanori en-aut-sei=Watanabe en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TangoYasuhisa en-aut-sei=Tango en-aut-mei=Yasuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawashimaTakeshi en-aut-sei=Kawashima en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UmeokaTatsuo en-aut-sei=Umeoka en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NisizakiMasahiko en-aut-sei=Nisizaki en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=2 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=3 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=4 en-affil= kn-affil=Department of Surgery, Shiga University of Medical Science affil-num=5 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=6 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=7 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=8 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry affil-num=9 en-affil= kn-affil=Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry en-keyword=epidermal growth factor receptor kn-keyword=epidermal growth factor receptor en-keyword=ZD1839 kn-keyword=ZD1839 en-keyword=akt kn-keyword=akt en-keyword=esophageal squamous cell cancer kn-keyword=esophageal squamous cell cancer en-keyword=tumor necrosis factor-related apoptosis inducing ligand kn-keyword=tumor necrosis factor-related apoptosis inducing ligand END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=3 article-no= start-page=826 end-page=829 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Glucosylation of Sucrose Laurate with Cyclodextrin Glucanotransferase en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester. en-copyright= kn-copyright= en-aut-name=OkadaKatsuhide en-aut-sei=Okada en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhaoHaisuo en-aut-sei=Zhao en-aut-mei=Haisuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Research & Development Center, Hayashibara Biochemical Laboratories, Inc. affil-num=2 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University en-keyword=cyclodextrin glucanotransferase kn-keyword=cyclodextrin glucanotransferase en-keyword=CGTase kn-keyword=CGTase en-keyword=sucrose monolaurate kn-keyword=sucrose monolaurate en-keyword=surfactant kn-keyword=surfactant END start-ver=1.4 cd-journal=joma no-vol=279 cd-vols= no-issue=4 article-no= start-page=313 end-page=322 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta gacA Delta gacS, were generated. These mutants produced smaller amounts of N-acyl homoserine lactones required for quorum sensing, had lost swarming motility, and had reduced expression of virulence-related hrp genes and the algT gene required for exopolysaccharide production. The ability of the mutants to cause disease symptoms in their host tobacco plant was remarkably reduced, while they retained the ability to induce hypersensitive reaction (HR) in the nonhost plants. These results indicated that the Gac two-component system of P. syringae pv. tabaci 6605 is indispensable for virulence on the host plant, but not for HR induction in the nonhost plants.

en-copyright= kn-copyright= en-aut-name=MarutaniMizuri en-aut-sei=Marutani en-aut-mei=Mizuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OgawaYujiro en-aut-sei=Ogawa en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HossainMijan Md. en-aut-sei=Hossain en-aut-mei=Mijan Md. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshishigeInagaki en-aut-sei=Yoshishige en-aut-mei=Inagaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University en-keyword=GacA kn-keyword=GacA en-keyword=GacS kn-keyword=GacS en-keyword=Pseudomonas syringae pv. tabaci kn-keyword=Pseudomonas syringae pv. tabaci en-keyword=quorum sensing kn-keyword=quorum sensing en-keyword=two-component system kn-keyword=two-component system END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=24 article-no= start-page=8739 end-page=8747 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080706 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Drosophila blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-fl is expressed in a temporally regulated manner following pulses of ecdysteroid and this precise expression is necessary for the development of Drosophila melanogaster. To understand how insect hormone ecdysteroids regulate the timing of FTZ-F1 expression, we purified a DNA binding regulator of ftz-fl. Mass spectroscopy analysis revealed this protein to be a fly homolog of mammalian B lymphocyte-induced maturation protein 1 (Blimp-1). Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly. Forced expression of dBlimp-1 and RNA interference analysis indicate that dBlimp-1 acts as a repressor and controls the timing of FTZ-F1 expression. Furthermore, its prolonged expression results in delay of pupation timing. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.

en-copyright= kn-copyright= en-aut-name=AgawaYasuo en-aut-sei=Agawa en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SarhanMoustafa en-aut-sei=Sarhan en-aut-mei=Moustafa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KageyamaYuji en-aut-sei=Kageyama en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkagiKazutaka en-aut-sei=Akagi en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaiMasayoshi en-aut-sei=Takai en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HashiyamaKazuya en-aut-sei=Hashiyama en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaTadashi en-aut-sei=Wada en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HandaHiroshi en-aut-sei=Handa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IwamatsuAkihiro en-aut-sei=Iwamatsu en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HiroseSusumu en-aut-sei=Hirose en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UedaHitoshi en-aut-sei=Ueda en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=7 en-affil= kn-affil=Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology affil-num=8 en-affil= kn-affil=Integrated Research Institute, Tokyo Institute of Technology affil-num=9 en-affil= kn-affil=Protein Research Network, Inc. affil-num=10 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=11 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University en-keyword=SEQUENTIAL GENE ACTIVATION kn-keyword=SEQUENTIAL GENE ACTIVATION en-keyword=MATURATION PROTEIN-1 BLIMP-1 kn-keyword=MATURATION PROTEIN-1 BLIMP-1 en-keyword=STEROID-RECEPTOR SUPERFAMILY kn-keyword=STEROID-RECEPTOR SUPERFAMILY en-keyword=POLYTENE CHROMOSOMES kn-keyword=POLYTENE CHROMOSOMES en-keyword=SALIVARY-GLAND kn-keyword=SALIVARY-GLAND en-keyword=FUSHI-TARAZU kn-keyword=FUSHI-TARAZU en-keyword=EMBRYONIC-DEVELOPMENT kn-keyword=EMBRYONIC-DEVELOPMENT en-keyword=MOLECULAR-MECHANISM kn-keyword=MOLECULAR-MECHANISM en-keyword=TEMPORAL REGULATION kn-keyword=TEMPORAL REGULATION en-keyword=STAGE SPECIFICITY kn-keyword=STAGE SPECIFICITY END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1078 end-page=1082 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of lipid derivatives of pyrrole polyamide and their biological activity en-subtitle= kn-subtitle= en-abstract= kn-abstract=Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide. en-copyright= kn-copyright= en-aut-name=YamamotoMasahiko en-aut-sei=Yamamoto en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhuChangjin en-aut-sei=Zhu en-aut-mei=Changjin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YiLui en-aut-sei=Yi en-aut-mei=Lui kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RongZheng en-aut-sei=Rong en-aut-mei=Zheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraYoshie en-aut-sei=Miura en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanamotoKen-ichi en-aut-sei=Tanamoto en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShimizuSakayu en-aut-sei=Shimizu en-aut-mei=Sakayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=3 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=4 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=5 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=National Institute of Health Sciences, Division of Food Additives affil-num=9 en-affil= kn-affil=Department of Applied Bioscience, Graduate School of Agriculture, Kyoto University affil-num=10 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=pyrrole polyamide kn-keyword=pyrrole polyamide en-keyword=lipid kn-keyword=lipid en-keyword=phospholipid kn-keyword=phospholipid en-keyword=cancer cell kn-keyword=cancer cell en-keyword=human immunodeficiency virus (HIV)-II kn-keyword=human immunodeficiency virus (HIV)-II END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=18 article-no= start-page=4175 end-page=4186 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Secretion of L-glutamate from osteoclasts through transcytosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Osteoclasts are involved in the catabolism of the bone matrix and eliminate the resulting degradation products through transcytosis, but the molecular mechanism and regulation of transcytosis remain poorly understood. Upon differentiation, osteoclasts express vesicular glutamate transporter 1 (VGLUT1), which is essential for vesicular storage and subsequent exocytosis of glutamate in neurons. VGLUT1 is localized in transcytotic vesicles and accumulates L-glutamate. Osteoclasts secrete L-glutamate and the bone degradation products upon stimulation with KCl or ATP in a Ca2+-dependent manner. KCl- and ATP-dependent secretion of L-glutamate was absent in osteoclasts prepared from VGLUT1-/- knockout mice. Osteoclasts express mGluR8, a class III metabotropic glutamate receptor. Its stimulation by a specific agonist inhibits secretion of L-glutamate and bone degradation products, whereas its suppression by a specific antagonist stimulates bone resorption. Finally, it was found that VGLUT1-/- mice develop osteoporosis. Thus, in bone-resorbing osteoclasts, L-glutamate and bone degradation products are secreted through transcytosis and the released L-glutamate is involved in autoregulation of transcytosis. Glutamate signaling may play an important role in the bone homeostasis. en-copyright= kn-copyright= en-aut-name=MorimotoRiyo en-aut-sei=Morimoto en-aut-mei=Riyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UeharaShunsuke en-aut-sei=Uehara en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YatsushiroShouki en-aut-sei=Yatsushiro en-aut-mei=Shouki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=JugeNarinobu en-aut-sei=Juge en-aut-mei=Narinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HuaZhaolin en-aut-sei=Hua en-aut-mei=Zhaolin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SenohShigenori en-aut-sei=Senoh en-aut-mei=Shigenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=EchigoNoriko en-aut-sei=Echigo en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HayashiMitsuko en-aut-sei=Hayashi en-aut-mei=Mitsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MizoguchiToshihide en-aut-sei=Mizoguchi en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NinomiyaTadashi en-aut-sei=Ninomiya en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UdagawaNobuyuki en-aut-sei=Udagawa en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OmoteHiroshi en-aut-sei=Omote en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoAkitsugu en-aut-sei=Yamamoto en-aut-mei=Akitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=EdwardsRobert H en-aut-sei=Edwards en-aut-mei=Robert H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MoriyamaYoshinori en-aut-sei=Moriyama en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Departments of Neurology and Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine affil-num=6 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Institute for Oral Science, Matsumoto Dental University affil-num=10 en-affil= kn-affil=Institute for Oral Science, Matsumoto Dental University affil-num=11 en-affil= kn-affil=Department of Biochemistry, Matsumoto Dental University affil-num=12 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Cell Biology, Nagahama Institute of Bioscience and Technology affil-num=14 en-affil= kn-affil=Departments of Neurology and Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine affil-num=15 en-affil= kn-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=osteoclast kn-keyword=osteoclast en-keyword=vesicular glutamate transporter kn-keyword=vesicular glutamate transporter en-keyword=transcytosis kn-keyword=transcytosis en-keyword=bone resorption kn-keyword=bone resorption END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=50 article-no= start-page=17923 end-page=17928 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A human transporter protein that mediates the final excretion step for toxic organic cations en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood. Here, we show that MATE1, a human and mouse orthologue of the multidrug and toxin extrusion (MATE) family conferring multidrug resistance on bacteria, is primarily expressed in the kidney and liver, where it is localized to the luminal membranes of the urinary tubules and bile canaliculi. When expressed in HEK293 cells, MATE1 mediates H+-coupled electroneutral exchange of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP). Its substrate specificity is similar to those of renal and hepatic H+-coupled organic cations (OCs) export. Thus, MATE1 appears to be the long searched for polyspecific OC exporter that directly transports toxic OCs into urine and bile.

en-copyright= kn-copyright= en-aut-name=OtsukaMasato en-aut-sei=Otsuka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoTakuya en-aut-sei=Matsumoto en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimotoRiyo en-aut-sei=Morimoto en-aut-mei=Riyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AriokaShigeo en-aut-sei=Arioka en-aut-mei=Shigeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OmoteHiroshi en-aut-sei=Omote en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoriyamaYoshinori en-aut-sei=Moriyama en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=MATE kn-keyword=MATE en-keyword=multidrug export kn-keyword=multidrug export en-keyword=excretion kn-keyword=excretion en-keyword=toxin kn-keyword=toxin en-keyword=urinary tubule kn-keyword=urinary tubule en-keyword=bile canaliculus kn-keyword=bile canaliculus en-keyword=organic cation kn-keyword=organic cation en-keyword=H+/cation antiport. kn-keyword=H+/cation antiport. END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=3 article-no= start-page=134 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of elevated plasma B-type natriuretic peptide levels with paroxysmal atrial fibrillation in patients with nonobstructive hypertrophic cardiomyopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients.
Methods: Patients (n=97) were classified into chronic AF (CAF; n=14), paroxysmal AF (PAF; n=18) and normal sinus rhythm (NSR; n=65) groups. The plasma BNP values were analyzed with logarithmic transformation.
Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; -1 SD and +1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p<0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p<0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level.
Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.

en-copyright= kn-copyright= en-aut-name=MatsuuraHiroko en-aut-sei=Matsuura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MurakamiTakashi en-aut-sei=Murakami en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HinaKazuyoshi en-aut-sei=Hina en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoKeizo en-aut-sei=Yamamoto en-aut-mei=Keizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawamuraHiroshi en-aut-sei=Kawamura en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SogoTaiji en-aut-sei=Sogo en-aut-mei=Taiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShinohataRyoko en-aut-sei=Shinohata en-aut-mei=Ryoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NinomiyaYoshifumi en-aut-sei=Ninomiya en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=3 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=4 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=5 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=6 en-affil= kn-affil=Department of Cardiovascular Medicine, Takamatsu Red Cross Hospital affil-num=7 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences affil-num=8 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences affil-num=9 en-affil= kn-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences en-keyword=clinical study kn-keyword=clinical study en-keyword=cardiomyopathy kn-keyword=cardiomyopathy en-keyword=tachyarrhythmia kn-keyword=tachyarrhythmia en-keyword=enzyme immunoassay kn-keyword=enzyme immunoassay en-keyword=peptide kn-keyword=peptide en-keyword=sensitivity and specificity kn-keyword=sensitivity and specificity END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=427 end-page=429 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080622 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.

en-copyright= kn-copyright= en-aut-name=KobayashiMakoto en-aut-sei=Kobayashi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KusanoKengo Fukushima en-aut-sei=Kusano en-aut-mei=Kengo Fukushima kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraYoichi en-aut-sei=Nakamura en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Ohta-OgoKeiko en-aut-sei=Ohta-Ogo en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NagaseSatoshi en-aut-sei=Nagase en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakuragiSatoru en-aut-sei=Sakuragi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OheTohru en-aut-sei=Ohe en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=aDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=aDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=cardiomyopathy kn-keyword=cardiomyopathy en-keyword=immunohistochemistry kn-keyword=immunohistochemistry en-keyword=monocyte kn-keyword=monocyte END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=5 article-no= start-page=648 end-page=652 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200805 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein en-subtitle= kn-subtitle= en-abstract= kn-abstract=The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the Ra-226 activity concentrations. en-copyright= kn-copyright= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshimoriYu en-aut-sei=Ishimori en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagamatsuTomohiro en-aut-sei=Nagamatsu en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=radioactivity kn-keyword=radioactivity en-keyword=radon emanation fraction kn-keyword=radon emanation fraction en-keyword=granite kn-keyword=granite en-keyword=Misasa kn-keyword=Misasa en-keyword=Badgastein kn-keyword=Badgastein END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=6 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vortex structure in spinor f=2 bose-einstein condensates en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Extended Gross-Pitaevskii equations for the rotating F=2 condensate in a harmonic trap are solved both numerically and variationally using trial functions for each component of the wave function. Axially symmetric vortex solutions are analyzed and energies of polar and cyclic states are calculated. The equilibrium transitions between different phases with changing of the magnetization are studied. We show that at high magnetization the ground state of the system is determined by interaction in "density" channel, and at low magnetization spin interactions play a dominant role. Although there are five hyperfine states, all the particles are always condensed in one, two, or three states. Two interesting types of vortex structures are also discussed.

en-copyright= kn-copyright= en-aut-name=PogosovW V en-aut-sei=Pogosov en-aut-mei=W V kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawateR en-aut-sei=Kawate en-aut-mei=R kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizushimaT en-aut-sei=Mizushima en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=vortices kn-keyword=vortices END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20072 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Theory of tunneling spectroscopy in the larkin-ovchinnikov state en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We present a theory of tunneling spectroscopy for normal metal/Larkin-Ovchinnikov state junctions in which the spatial periodic modulation in the pair potential amplitude is taken into account. The tunneling spectra show the characteristic line shapes reflecting the minigap structures under the periodic pair potentials depending on the boundary condition of the pair potentials at the junction interface. These features are qualitatively different from the tunneling spectra of the Fulde-Ferrell state. We propose an experimental setup which identifies the superconducting state of CeCoIn5.

en-copyright= kn-copyright= en-aut-name=TanakaYukio en-aut-sei=Tanaka en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AsanoYasuhiro en-aut-sei=Asano en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchikawaMasanori en-aut-sei=Ichikawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KashiwayaSatoshi en-aut-sei=Kashiwaya en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Nagoya University affil-num=2 en-affil= kn-affil=Japan Science and Technology Corporation affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=NeRI of National Institute of Advanced Industrial Science and Technology END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sound velocity and multibranch bogoliubov spectrum of an elongated fermi superfluid in the BEC-BCS crossover en-subtitle= kn-subtitle= en-abstract= kn-abstract=We study properties of excited states of an elongated Fermi superfluid along the Bose-Einstein-condensate-BCS crossover including the unitarity limit. Analytic expressions for the sound velocity in an inhomogeneous as well as homogeneous Fermi superfluid along the crossover are obtained on the basis of the hydrodynamic theory. The complete excitation spectrum of axial quasiparticles with various discrete radial nodes is presented. We discuss the feasibility of measuring the sound velocity and the multibranch Bogoliubov spectrum experimentally. en-copyright= kn-copyright= en-aut-name=GhoshTarun Kanti en-aut-sei=Ghosh en-aut-mei=Tarun Kanti kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MachidaKazushige en-aut-sei=Machida en-aut-mei=Kazushige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=bose-einstein condensate kn-keyword=bose-einstein condensate en-keyword=gas kn-keyword=gas en-keyword=propagation kn-keyword=propagation en-keyword=resonance kn-keyword=resonance END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Multibranch Bogoliubov-Bloch spectrum of a cigar-shaped Bose condensate in an optical lattice en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We study properties of excited states of an array of weakly coupled quasi-two-dimensional Bose condensates by using the hydrodynamic theory. The spectrum of the axial excited states strongly depends on the coupling among the various discrete radial modes in a given symmetry. By including mode coupling within a given symmetry, the complete excitation spectrum of axial quasiparticles with various discrete radial nodes are presented. A single parameter which determines the strength of the mode coupling is identified. The excitation spectrum in the zero angular momentum sector can be observed by using the Bragg scattering experiments.

en-copyright= kn-copyright= en-aut-name=GhoshTarun Kanti en-aut-sei=Ghosh en-aut-mei=Tarun Kanti kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MachidaK. en-aut-sei=Machida en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=einstein kn-keyword=einstein en-keyword=condensate kn-keyword=condensate en-keyword=superfluid kn-keyword=superfluid en-keyword=arrays kn-keyword=arrays en-keyword=atoms kn-keyword=atoms en-keyword=wave kn-keyword=wave en-keyword=gas kn-keyword=gas END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Observation of a superconducting gap in boron-doped diamond by laser-excited photoemission spectroscopy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

<p>We investigate the temperature (T)-dependent low-energy electronic structure of a boron-doped diamond thin film using ultrahigh resolution laser-excited photoemission spectroscopy. We observe a clear shift of the leading edge below T=11 K, indicative of a superconducting gap opening (Delta~0.78 meV at T=4.5 K). The gap feature is significantly broad and a well-defined quasiparticle peak is lacking even at the lowest temperature of measurement (=4.5 K). We discuss our results in terms of disorder effects on the normal state transport and superconductivity in this system.</p>

en-copyright= kn-copyright= en-aut-name=IshizakaK. en-aut-sei=Ishizaka en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiR. en-aut-sei=Eguchi en-aut-mei=R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsudaS. en-aut-sei=Tsuda en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokotaT. en-aut-sei=Yokota en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ChainaniA. en-aut-sei=Chainani en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KissT. en-aut-sei=Kiss en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShimojimaT. en-aut-sei=Shimojima en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TogashiT. en-aut-sei=Togashi en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=WatanabeS. en-aut-sei=Watanabe en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ChenC. T. en-aut-sei=Chen en-aut-mei=C. T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ZhangC. Q. en-aut-sei=Zhang en-aut-mei=C. Q. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakanoY. en-aut-sei=Takano en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NagaoM. en-aut-sei=Nagao en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SakuguchiI. en-aut-sei=Sakuguchi en-aut-mei=I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TakenouchiT. en-aut-sei=Takenouchi en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=ShinS. en-aut-sei=Shin en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=University of Tokyo affil-num=2 en-affil= kn-affil=The Institute of Physical and Chemical Research (RIKEN) affil-num=3 en-affil= kn-affil=University of Tokyo affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=The Institute of Physical and Chemical Research (RIKEN) affil-num=6 en-affil= kn-affil=The Institute of Physical and Chemical Research (RIKEN) affil-num=7 en-affil= kn-affil=University of Tokyo affil-num=8 en-affil= kn-affil=The Institute of Physical and Chemical Research (RIKEN) affil-num=9 en-affil= kn-affil=University of Tokyo affil-num=10 en-affil= kn-affil=Chinese Academy of Science affil-num=11 en-affil= kn-affil=Chinese Academy of Science affil-num=12 en-affil= kn-affil=National Institute for Materials Science affil-num=13 en-affil= kn-affil=National Institute for Materials Science affil-num=14 en-affil= kn-affil=National Institute for Materials Science affil-num=15 en-affil= kn-affil=Waseda University affil-num=16 en-affil= kn-affil=University of Tokyo END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20068 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cyclic phase in f=2 spinor condensate:long-range order, kinks, and roughening transition en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We study the effect of thermal fluctuations on homogeneous infinite Bose-Einstein condensate with spin F=2 in the cyclic state, when atoms occupy three hyperfine states with m(F)=0,+/- 2. We use both the approach of small-amplitude oscillations and mapping of our model on the sine-Gordon model. We show that thermal fluctuations lead to the existence of the rough phase in one- and two-dimensional systems, when the presence of kinks is favorable. The structure and energy of a single kink are found. We also discuss the effect of thermal fluctuations on spin degrees of freedom in F=1 condensate.

en-copyright= kn-copyright= en-aut-name=PogosovW V en-aut-sei=Pogosov en-aut-mei=W V kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=bose-einstein condensate kn-keyword=bose-einstein condensate en-keyword=dynamics kn-keyword=dynamics en-keyword=gases kn-keyword=gases END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20068 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Thermal fluctuations of vortex clusters in quasi-two-dimensional bose-einstein condensates en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We study the thermal fluctuations of vortex positions in small vortex clusters in a harmonically trapped rotating Bose-Einstein condensate. It is shown that the order-disorder transition of two-shell clusters occurs via the decoupling of shells with respect to each other. The corresponding "melting" temperature depends strongly on the commensurability between numbers of vortices in shells. We show that melting can be achieved at experimentally attainable parameters and very low temperatures. Also studied is the effect of thermal fluctuations on vortices in an anisotropic trap with small quadrupole deformation. We show that thermal fluctuations lead to the decoupling of a vortex cluster from the pinning potential produced by this deformation. The decoupling temperatures are estimated and strong commensurability effects are revealed.

en-copyright= kn-copyright= en-aut-name=PogosovW V en-aut-sei=Pogosov en-aut-mei=W V kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=scissors mode kn-keyword=scissors mode en-keyword=gas kn-keyword=gas en-keyword=superfluidity kn-keyword=superfluidity en-keyword=transition kn-keyword=transition en-keyword=stability kn-keyword=stability en-keyword=phase kn-keyword=phase END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=8 article-no= start-page=1343 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20068 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Using assessment of higher brain functions of children with GJB2-associated deafness and cochlear implants as a procedure to evaluate language development en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Objective: While investigators have reported that patients with GJB2-associated deafness and cochlear implants have preferable language development, the mechanisms of this phenomenon remains unknown. The goat of the present study was to assess higher brain functions of patients with GJB2-retated and GJB2-unrelated deafness as a method of evaluating language development.
Methods: Eight children with cochlear implants were subjected to genetic testing for GJB2 and underwent the Raven colored progressive matrices test, Rey's auditory verbal learning test, Rey's complex figure test, the standardized Language test for aphasia, the picture vocabulary test, and the standardized comprehension test for abstract words.
Results:Three children were diagnosed with GJB2-related deafness, and five children were diagnosed with GJB2-unrelated deafness. All three GJB2-related cases demonstrated normal range higher brain functions and fair language development. By contrast, one GJB2-unrelated case showed a semantic disorder, another demonstrated a visual cognitive disorder with dyslexia, and another had attention deficit-hyperactivity disorder.
Conclusions:Children with GJB2-unrelated deafness showed a high frequency of heterogeneous disorders that can affect proper language development. This difference between children with GJB2-retated and GJB2-unrelated deafness may account for the improved language development in children with GJB2-related deafness and cochlear implants. Further, genetic diagnosis of the non-syndromic hearing toss represents a useful tool for the preoperative prediction of outcomes following a cochlear implant procedure.

en-copyright= kn-copyright= en-aut-name=KawasakiAkihiro en-aut-sei=Kawasaki en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukushimaKunihiro en-aut-sei=Fukushima en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukudaShoichiro en-aut-sei=Fukuda en-aut-mei=Shoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=cochlear implant kn-keyword=cochlear implant en-keyword=higher brain function kn-keyword=higher brain function en-keyword=GJB2 kn-keyword=GJB2 en-keyword=language development kn-keyword=language development en-keyword=non-syndromic hearing loss kn-keyword=non-syndromic hearing loss en-keyword=learninng disability kn-keyword=learninng disability END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=1 article-no= start-page=o17 end-page=o20 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hydrogen bonding in two solid phases of phenazine-chloranilic acid (1/1) determined at 170 and 93 K en-subtitle= kn-subtitle= en-abstract= kn-abstract=The crystal structures in two solid phases, i.e. phase II stable between 146 and 253 K and phase IV below 136 K, of the title compound [phenazine-chloranilic acid (1/1), C12H8N2 center dot C6H2Cl2O4, in phase II, and phenazinium hydrogen chloranilate, C12H9N2+center dot C6HCl2O4-, in phase IV], have been determined. Both phases crystallize in P2(1), and each structure was refined as an inversion twin. In phase II, the phenazine and chloranilic acid molecules are arranged alternately through two kinds of O-H center dot center dot center dot N hydrogen bonds. In phase IV, salt formation occurs by donation of one H atom from the chloranilic acid molecule to the phenazine molecule; the resulting monocation and monoanion are linked by N-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds. en-copyright= kn-copyright= en-aut-name=GotohKazuma en-aut-sei=Gotoh en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AsajiTetsuo en-aut-sei=Asaji en-aut-mei=Tetsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshidaHiroyuki en-aut-sei=Ishida en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Graduate School of Integrated Basic Sciences, College of Humanities and Sciences, Nihon University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=24 article-no= start-page=5800 end-page=5807 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=RhCl3/amine-catalyzed [2+2+2] cyclization of alkynes en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The RhCl3-3H(2)O/i-Pr2NEt-catalyzed [2+2+2] cyclotrimerization of alkynes has been achieved. The reaction can be widely used for various alkynes and provides tri- OF hexa-substituted benzenes regioselectively in high yields. The [2+2+2] cycloaddition of diynes and alkynes is also developed, and it affords benzene derivatives in moderate to high yields.

en-copyright= kn-copyright= en-aut-name=YoshidaKenta en-aut-sei=Yoshida en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoIchiro en-aut-sei=Morimoto en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaHideo en-aut-sei=Tanaka en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, affil-num=2 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=Rh/amine catalyst kn-keyword=Rh/amine catalyst en-keyword=cyclotrimerization kn-keyword=cyclotrimerization en-keyword=hexa-substituted benzene kn-keyword=hexa-substituted benzene END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=24 article-no= start-page=4167 end-page=4179 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis and regioselective N- and O-alkylation of 1H- or 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones (8-azaxanthines) and transformation of their 3-alkyl derivatives into 1-alkyl isomers en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Several alkylating agents, for example alkyl halides and dimethyl sulfate, were employed in aprotic Solvents Under a variety of conditions for the alkylation of mono- and disubstituted 1H- or 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones, which were prepared by cyclization of the appropriate 5,6-diaminouracils with nitrous acid. The alkylation on the triazole ring in the presence of anhydrous potassium carbonate took place simultaneously at the 1- and 2-positions, with alkylation at the 2-position taking priority. Similar alkylation on the pyrimidine ring with an equivalent alkylating reagent took place only at the 4-position. The alkylation of 3,6-disubstituted derivatives at room temperature led to 5-O-alkylation accompanied by 4-N-alkylation, but at high temperature only 4-N-alkylation took place. Reaction of 3,4,6-trisubstituted derivatives with excess alkylating agent at high temperature leads to the formation of 1,4,6-trisubstituted derivatives with elimination of the 3-substituent.

en-copyright= kn-copyright= en-aut-name=IslamRafiqul en-aut-sei=Islam en-aut-mei=Rafiqul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutica?l Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutica?l Sciences, Okayama University en-keyword=8-azaxanthines kn-keyword=8-azaxanthines en-keyword=triazolopyrimidines kn-keyword=triazolopyrimidines en-keyword=regioselectivity kn-keyword=regioselectivity en-keyword=alkylations kn-keyword=alkylations en-keyword=heterocycles kn-keyword=heterocycles END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=11 article-no= start-page=2327 end-page=2329 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20043 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enantioselective construction of biaryl part in the synthesis of stegane related compounds en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A Pd-mediated intramolecular aryl-aryl coupling reaction of phenyl benzoate derivatives were examined to form benzo[c]chromen-6-ones, and then enantioselective lactone-opening reaction with a borane-oxazaborolidine combination was carried out. The resulting biphenyl was transformed into a key intermediate for the stegane related compounds. The absolute configuration of the biphenyl is also discussed. Stegane and related compounds are important because of their interesting biological activities such as antileukemic properties.1 One of the most outstanding features of their chemical structures is an unsymmetrical 2,2f-disubstituted biphenyl moiety with an axial chirality (Figure 1). For the formation of such a biphenyl part in the syntheses of the stegane families, several approaches have been attempted such as photocyclization,2 Suzuki coupling,3 oxidative biaryl coupling,4 the SNAr reaction,5 Ullmann coupling,6 and the [2+2+2] three-component cyclization reaction.7

en-copyright= kn-copyright= en-aut-name=AbeHitoshi en-aut-sei=Abe en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakedaShigemitsu en-aut-sei=Takeda en-aut-mei=Shigemitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujitaTakuro en-aut-sei=Fujita en-aut-mei=Takuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishiokaKeisuke en-aut-sei=Nishioka en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeuchiYasuo en-aut-sei=Takeuchi en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HarayamaTakashi en-aut-sei=Harayama en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=steganone kn-keyword=steganone en-keyword=palladium kn-keyword=palladium en-keyword=phenyl benzoate kn-keyword=phenyl benzoate en-keyword=lactone concept kn-keyword=lactone concept en-keyword=biary kn-keyword=biary END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=922 end-page=940 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones followed by nucleophilic replacement of the 2-methylthio moiety by different amines, and acidic hydrolysis of the 2-methylthio moiety afforded the corresponding flavin derivatives. 2-Deoxo-2-methylthio-5-deazaalloxazines and 2-deoxo-2-methylthioalloxazine-5-oxides were also prepared by Vilsmeier reaction and by nitrosation of 6-anilino-2-methylthiopyrimidin-4(3H)-ones, respectively. Then, they were subjected to nucleophilic replacement with appropriate amines to produce the corresponding 2-alkylamino derivatives. Regiospecific N-3-alkylation of 2-deoxo-2-methylthioalloxazine-5-oxides was carried out with various alkylating agents in the usual way, The antitumor activities against CCRF-HSB-2 and KB tumor cells have been investigated in vitro, and many compounds showed promising antitumor activities. Furthermore, AutoDock molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors. en-copyright= kn-copyright= en-aut-name=AliHamed I. en-aut-sei=Ali en-aut-mei=Hamed I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=3 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=flavin-5-oxide kn-keyword=flavin-5-oxide en-keyword=alloxazine-5-oxide kn-keyword=alloxazine-5-oxide en-keyword=AutoDock kn-keyword=AutoDock END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=51 article-no= start-page=11969 end-page=11975 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reactivity of TEMPO anion as a nucleophile and its applications for selective transformations of haloalkanes or acyl halides to aldehydes en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Sodium 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO−Na+), generated by reduction of TEMPO? with sodium naphthalenide in THF, reacted with alkyl halides or acyl halides to produce O-alkylated or acylated TEMPOs, which were in turn oxidized with mCPBA or reduced with DIBAL-H to afford the corresponding aldehydes, thus accomplishing a new protocol for the halides-carbonyls conversion.

en-copyright= kn-copyright= en-aut-name=InokuchiTsutomu en-aut-sei=Inokuchi en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawafuchiHiroyuki en-aut-sei=Kawafuchi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Toyama National College of Technology en-keyword=TEMPO and compounds kn-keyword=TEMPO and compounds en-keyword=Oxidation kn-keyword=Oxidation en-keyword=Reduction kn-keyword=Reduction en-keyword=mCPBA kn-keyword=mCPBA en-keyword=DIBAL-H kn-keyword=DIBAL-H en-keyword=Aldehyde kn-keyword=Aldehyde END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=15 article-no= start-page=2363 end-page=2365 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Facile synthetic procedure for and electrochemical properties of hexa(2-thienyl)benzenes directed toward electroactive materials en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In the presence of RhCl3 center dot 3H(2)O and i-Pr2NEt, the cyclotrimerization of di(2-thienyl)acetylenes proceeded smoothly to afford hexa(2-thienyl)benzenes. CV analysis of the hexa(2-thienyl)benzenes showed that they may be useful as electroactive materials.

en-copyright= kn-copyright= en-aut-name=YoshidaKenta en-aut-sei=Yoshida en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoIchiro en-aut-sei=Morimoto en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaHideo en-aut-sei=Tanaka en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=Rh/amine catalyst kn-keyword=Rh/amine catalyst en-keyword=cyclotrimerization kn-keyword=cyclotrimerization en-keyword=hexa(2-thienyl)benzene kn-keyword=hexa(2-thienyl)benzene en-keyword=electroactive material kn-keyword=electroactive material END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=18 article-no= start-page=3197 end-page=3200 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20055 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of graphislactones A-D through a palladium-mediated biaryl coupling en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The chemical synthesis of graphislactones A-D was achieved through the Pd-mediated intramolecular biaryl coupling reaction of phenyl benzoate derivatives.

en-copyright= kn-copyright= en-aut-name=AbeHitoshi en-aut-sei=Abe en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiokaKeisuke en-aut-sei=Nishioka en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakedaShigemitsu en-aut-sei=Takeda en-aut-mei=Shigemitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AraiMasatsugu en-aut-sei=Arai en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeuchiYasuo en-aut-sei=Takeuchi en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HarayamaTakashi en-aut-sei=Harayama en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=Palladium kn-keyword=Palladium en-keyword=Phenyl benzoate kn-keyword=Phenyl benzoate en-keyword=Graphislactone kn-keyword=Graphislactone en-keyword=Biaryl coupling kn-keyword=Biaryl coupling END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=242 end-page=256 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents en-subtitle= kn-subtitle= en-abstract= kn-abstract=Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, and KB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC50 and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK. en-copyright= kn-copyright= en-aut-name=AliHamed I.. en-aut-sei=Ali en-aut-mei=Hamed I.. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomitaKeiichiro en-aut-sei=Tomita en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkahoEiichi en-aut-sei=Akaho en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KambaraHiroto en-aut-sei=Kambara en-aut-mei=Hiroto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraShinji en-aut-sei=Miura en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HayakawaHiroyuki en-aut-sei=Hayakawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawashimaYutaka en-aut-sei=Kawashima en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamagishiTakehiro en-aut-sei=Yamagishi en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkeyaHisao en-aut-sei=Ikeya en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YonedaFumio en-aut-sei=Yoneda en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University affil-num=4 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University affil-num=5 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=6 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=7 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=8 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=9 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=10 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=11 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, Kyoto University affil-num=12 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=Flavin analog kn-keyword=Flavin analog en-keyword=AutoDock kn-keyword=AutoDock en-keyword=protein tyrosine kinase kn-keyword=protein tyrosine kinase END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue= article-no= start-page=595 end-page=605 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=New dimeric flavans from gambir, an extract of Uncaria gambir en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Three new dimeric flavans, catechin-(4 alpha -> 8)-ent-epicatechin (7), gambirflavan D1 (8), and gambirflavan D2 (9), were isolated from gambir (an extract from the leaves and young twigs of Uncaria gambir), and their structures were determined based on spectroscopic and chemical data.

en-copyright= kn-copyright= en-aut-name=TaniguchiShoko en-aut-sei=Taniguchi en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaKayo en-aut-sei=Kuroda en-aut-mei=Kayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshikadoNaomi en-aut-sei=Yoshikado en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DoiKou-ichi en-aut-sei=Doi en-aut-mei=Kou-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanabeMasahiro en-aut-sei=Tanabe en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShibataTakashi en-aut-sei=Shibata en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaTakashi en-aut-sei=Yoshida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=2 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=4 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=5 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=6 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=7 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=8 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University en-keyword=PROCYANIDINS kn-keyword=PROCYANIDINS END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=19 article-no= start-page=6336 end-page=6352 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 3: Design, synthesis, antitumor activity, and molecular docking study of novel 2-methylthio-, 2-amino-, and 2-(N-substituted amino)-10-alkyl-2-deoxo-5-deazaflavins en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various novel 10-alkyl-2-deoxo-2-methylthio-5-deazaflavins have been synthesized by reaction of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones with Vilsmeier reagent. The similar 2-(N-substituted amino) derivatives were prepared by nucleophilic replacement reaction of the 2-methylthio moiety by appropriate amines. The 2-oxo derivatives (i.e., 5-deazaflavins) were obtained by acidic hydrolysis of the 2-methylthio derivatives. The antitumor activities against CCRF-HSB-2 and KB cells and the antiviral activities against HSV-1 and HSV-2 have been investigated in vitro, and many compounds showed promising antitumor activities. Furthermore, AutoDock molecular docking into PTK has been done for lead optimization of these compounds as potential PTK inhibitors. Whereas, the designed 2-deoxo-5-deazaflavins connected with amino acids at the 2-position exhibited the good binding affinities into PTK with more hydrogen bonds. en-copyright= kn-copyright= en-aut-name=AliHamed I. en-aut-sei=Ali en-aut-mei=Hamed I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=3 en-affil= kn-affil=aDepartment of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=5-deazaflavin kn-keyword=5-deazaflavin en-keyword=AutoDock kn-keyword=AutoDock en-keyword=protein tyrosine kn-keyword=protein tyrosine en-keyword=kinase kn-keyword=kinase END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=6 article-no= start-page=1021 end-page=1025 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alkaline hydrothermal treatment of brominated high impact polystyrene (HIPS-Br) for bromine and bromine-free plastic recovery en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A method to recover both Br and Br-free plastic from brominated flame retardant high impact polystyrene (HIPS-Br) was proposed. HIPS-Br containing 15% Br was treated in autoclave at 280Ž using water or KOH solution of various amounts and concentrations. Hydrothermal treatment (30 ml water) leads to 90% debromination of 1 g HIPS-Br but plastic is strongly degraded and could not be recovered. previous termAlkalinenext term hydrothermal treatment (45 ml or 60 ml KOH 1 M) showed similar debromination for up to 12 g HIPS-Br and plastic was recovered as pellets with molecular weight distribution close to that of the initial material. Debromination occurs at melt plastic/KOH solution interface when liquid/vapour equilibrium is attained inside autoclave (280Ž and 7 MPa in our experimental conditions) and depends on the plastic amount/KOH volume ratio. The antimony oxide synergist from HIPS-Br remains in recovered plastic during treatment. A pictorial imagination of the proposed debromination process is presented.

en-copyright= kn-copyright= en-aut-name=BrebuMihai en-aut-sei=Brebu en-aut-mei=Mihai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BhaskarThallada en-aut-sei=Bhaskar en-aut-mei=Thallada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MutoAkinori en-aut-sei=Muto en-aut-mei=Akinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakataYusaku en-aut-sei=Sakata en-aut-mei=Yusaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Petru Poni Institute of Macromolecular Chemistry affil-num=2 en-affil= kn-affil=Department of Applied Chemistry, Faculty of Engineering, Okayama University affil-num=3 en-affil= kn-affil=Department of Applied Chemistry, Faculty of Engineering, Okayama University affil-num=4 en-affil= kn-affil=Department of Applied Chemistry, Faculty of Engineering, Okayama University en-keyword=Debromination kn-keyword=Debromination en-keyword=Alkaline hydrotreatment kn-keyword=Alkaline hydrotreatment en-keyword=HIPS-Br kn-keyword=HIPS-Br en-keyword=Bromine recovery kn-keyword=Bromine recovery END start-ver=1.4 cd-journal=joma no-vol=149 cd-vols= no-issue=6 article-no= start-page=2816 end-page=2825 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Circulating aldosterone concentrations occasionally increase after initial suppression with angiotensin II (Ang II) converting enzyme inhibitors or Ang II type 1 receptor blockers (ARBs), a phenomenon referred to as aldosterone breakthrough. However, the underlying mechanism causing the aldosterone breakthrough remains unknown. Here we investigated whether aldosterone breakthrough occurs in human adrenocortical H295R cells in vitro. We recently reported that bone morphogenetic protein (BMP)-6, which is expressed in adrenocortical cells, enhances Ang II-but not potassium-induced aldosterone production in human adrenocortical cells. Accordingly, we examined the roles of BMP-6 in aldosterone breakthrough induced by long-term treatment with ARB. Ang II stimulated aldosterone production by adrenocortical cells. This Ang II stimulation was blocked by an ARB, candesartan. Interestingly, the candesartan effects on Ang II-induced aldosterone synthesis and CYP11B2 expression were attenuated in a course of candesartan treatment for 15 d. The impairment of candesartan effects on Ang II-induced aldosterone production was also observed in Ang II- or candesartanpretreated cells. Levels of Ang II type 1 receptor mRNA were not changed by chronic candesartan treatment. However, BMP-6 enhancement of Ang II- induced ERK1/2 signaling was resistant to candesartan. The BMP-6-induced Smad1, -5, and -8 phosphorylation, and BRE-Luc activity was augmented in the presence of Ang II and candesartan in the chronic phase. Chronic Ang II exposure decreased cellular expression levels of BMP-6 and its receptors activin receptor-like kinase-2 and activin type II receptor mRNAs. Cotreatment with candesartan reversed the inhibitory effects of Ang II on the expression levels of these mRNAs. The breakthrough phenomenon was attenuated by neutralization of endogenous BMP-6 and activin receptor-like kinase-2. Collectively, these data suggest that changes in BMP-6 availability and response may be involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.

en-copyright= kn-copyright= en-aut-name=OtaniHiroyuki en-aut-sei=Otani en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InagakiKenichi en-aut-sei=Inagaki en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiJiro en-aut-sei=Suzuki en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanoYoshihiro en-aut-sei=Kano en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GotoJunko en-aut-sei=Goto en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=ENZYME-INHIBITOR THERAPY kn-keyword=ENZYME-INHIBITOR THERAPY en-keyword=CHRONIC HEART-FAILURE kn-keyword=CHRONIC HEART-FAILURE en-keyword=CONVERTING ENZYME kn-keyword=CONVERTING ENZYME en-keyword=HYPERTENSIVE PATIENTS kn-keyword=HYPERTENSIVE PATIENTS en-keyword=PLASMA-ALDOSTERONE kn-keyword=PLASMA-ALDOSTERONE en-keyword=GRANULOSA-CELLS kn-keyword=GRANULOSA-CELLS en-keyword=SYSTEM kn-keyword=SYSTEM en-keyword=SECRETION kn-keyword=SECRETION en-keyword=NEPHROPATHY kn-keyword=NEPHROPATHY en-keyword=HYPERTROPHY kn-keyword=HYPERTROPHY END start-ver=1.4 cd-journal=joma no-vol=152 cd-vols= no-issue=11 article-no= start-page=173 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High-aspect-ratio copper-via-filling for three-dimensional chip stacking - II. Reduced electrodeposition process time en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Through-chip electrodes for three-dimensional packaging can offer short interconnection and reduced signal delay. Formation of suitable vias by electrodeposition into cavities presents a filling problem similar to that encountered in the damascene process. Because via dimensions for through-chip filling are larger and have a higher aspect ratio relative to features in damascene, process optimization requires modification of existing superconformal plating baths and plating parameters. In this study, copper filling of high-aspect-ratio through-chip vias was investigated and optimized with respect to plating bath composition and applied current wavetrain. Void-free vias 70 mu m deep and 10 mu m wide were formed in 60 min using additives in combination with pulse-reverse current and dissolved-oxygen enrichment. The effects of reverse current and dissolved oxygen on the performance of superfilling additives is discussed in terms of their effects on formation, destruction, and distribution of a Cu(I) thiolate accelerant. (c) 2005 The Electrochemical Society. All rights reserved.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YonezawaToshihiro en-aut-sei=Yonezawa en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MikamiDaisuke en-aut-sei=Mikami en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkuboToshikazu en-aut-sei=Okubo en-aut-mei=Toshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaguchiYuichi en-aut-sei=Taguchi en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiKenji en-aut-sei=Takahashi en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BarkeyDale P en-aut-sei=Barkey en-aut-mei=Dale P kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Osaka Prefecture University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Toppan Printing Company, Limited affil-num=5 en-affil= kn-affil=Tsukuba Center Incorporated affil-num=6 en-affil= kn-affil=Tsukuba Center Incorporated affil-num=7 en-affil= kn-affil=University of New Hampshire en-keyword=plating baths kn-keyword=plating baths en-keyword=additives kn-keyword=additives END start-ver=1.4 cd-journal=joma no-vol=152 cd-vols= no-issue=10 article-no= start-page=688 end-page=691 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of annealing and hydrogen on properties of electrodeposited platinum electrode and lead-zirconate-titanate films for ferroelectric random access memory applications en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The selection of capacitor electrode materials for the nonvolatile ferroelectric random access memory is one of the most important issues because capacitor electrical characteristics are strongly influenced by the electrode materials. The lower Pt electrode was electrodeposited on the Ti seed/Pt seed layer. Two different thicknesses of Ti seed layer (5 and 15 nm) were adopted, and lead-zirconate-titanate (PZT) was deposited on the electrodeposited Pt. The Pt crystal orientation with a 5 nm Ti seed layer is much better than that with a 15 nm Ti seed layer, and the deposited PZT shows much better crystal orientation. Due to better crystal orientation of the PZT layer in the case of a 5 nm Ti seed layer, a Pt/PZT/Pt capacitor well-saturated D-V hysteresis loop was obtained whereas little current was observed in the large electric field. With the 15 nm Ti seed layer, numerous several-mu m-sized voids formed on the lower Pt electrode surface. With the 5 nm Ti seed layer, fewer voids formed on the lower Pt electrode surface. Glow discharge spectrometry measurement with a 15 nm Ti seed layer shows much higher H intensity than that with a 5 nm Ti seed layer, and the H peak coincides with the Ti peak. The H existing in the Ti seed layer must have transmitted into the PZT layer and deteriorated the PZT crystal orientation. (c) 2005 The Electrochemical Society.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeKeiji en-aut-sei=Watanabe en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeYuji en-aut-sei=Abe en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HajiJunko en-aut-sei=Haji en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimizuMasaru en-aut-sei=Shimizu en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Osaka Prefecture University affil-num=2 en-affil= kn-affil=Osaka Prefecture University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=University of Hyogo en-keyword=chemical-vapor-deposition kn-keyword=chemical-vapor-deposition en-keyword=electrical-properties kn-keyword=electrical-properties END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=10 article-no= start-page=1109 end-page=1119 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polar and hydrogen-bonding effects of alcohols on the emission spectrum of styrene-triethylamine system en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The emission spectra of styrene (ST)-triethylamine (TEA) systems were measured under steady-state illumination conditions in some THF-protic solvent mixtures. The fluorescence spectrum of the ST-TEA system in THF consists of two bands (band A at 304 nm (fluorescence of ST) and band B at 460 nm (emission from an exciplex)). The intensity of band A increased and that of band B decreased with increasing amounts of protic solvents in THF-protic solvent mixtures. The increase in the intensity of band A was explained by the decrease in the concentration of free amine owing to the hydrogen-bonding interaction (or protonation) between TEA and protic solvents. The decrease in the intensity of band B was considered to be caused by the decrease in the concentration of free amine on the addition of protic solvents and the enhanced conversion of the exciplex to an ion pair with increasing solvent polarity. The polar effect was expressed as a function of the relative permittivity of the solution.

en-copyright= kn-copyright= en-aut-name=YamamotoShunzo en-aut-sei=Yamamoto en-aut-mei=Shunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=Solvent effect; Hydrogen-bonding; Polar effect; Exciplex; Fluorescence kn-keyword=Solvent effect; Hydrogen-bonding; Polar effect; Exciplex; Fluorescence END start-ver=1.4 cd-journal=joma no-vol=145 cd-vols= no-issue=9 article-no= start-page=3007 end-page=3010 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19989 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Shape evolution of electrodeposited bumps with deep cavity en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Electrodeposited bumps are the indispensable microconnectors for high-density interconnection in the latest microelectronics applications. The deep cavities are especially important for the solder bumps for ball grid arrays. This investigation discusses the relation between cavity shapes and current distributions of deep cavities. The role of convection and diffusion within the cavities is calculated at diffusion-limited overpotentials with numerical fluid dynamics computations. The current distributions become symmetric and peak profiles become sharper for the deeper cavities of large aspect ratios and of negative photoresist angles, theta. For 30 mu m cathode length, the current at the center is larger than that at the edges for photoresist angles of theta less than or equal to 0. For these deep cavities, the convection outside the cavity is not related to the current distribution and the current distribution is determined by the cavity shape. The mass transport within the deep cavities is controlled mainly by diffusion. This is because the convection outside the cavities is not effectively stirring inside the deep cavities.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiKeisuke en-aut-sei=Fukui en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Himeji Institute of Technology en-keyword=copper bumps kn-keyword=copper bumps END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=9 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formation of ice nanotube with hydrophobic guests inside carbon nanotube en-subtitle= kn-subtitle= en-abstract= kn-abstract=A composite ice nanotube inside a carbon nanotube has been explored by molecular dynamics and grandcanonical Monte Carlo simulations. It is made from an octagonal ice nanotube whose hollow space contains hydrophobic guest molecules such as neon, argon, and methane. It is shown that the attractive interaction of the guest molecules stabilizes the ice nanotube. The guest occupancy of the hollow space is calculated by the same method as applied to clathrate hydrates. en-copyright= kn-copyright= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=ice nanotubes kn-keyword=ice nanotubes en-keyword=carbon nanotubes kn-keyword=carbon nanotubes END start-ver=1.4 cd-journal=joma no-vol=151 cd-vols= no-issue=7 article-no= start-page=514 end-page=518 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20046 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Crystal growth of electrolytic cu foil en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Electrolytic copper deposited on (100)(Cu) single crystals forms pyramidal crystals that grow parallel to the substrate at low current density without stirring. With stirring and higher current density, slanting platelet crystals with (111)(Cu) orientation are formed. Chloride and gelatin are typical additives for electrolytic copper foils and the electrolytic copper foils are formed on a titanium substrate with a stirring rate and high current density. With gelatin, triangular pyramidal crystals form with (111)(Cu) orientation. The triangle-shaped side planes of the crystals are the (100)(Cu), and platelet crystals exist along the (100)(Cu). With chloride and gelatin, triangular columnar crystals with the (110)(Cu) orientation are formed. The triangle-shaped side planes of the crystals are the (100)(Cu) and the platelet crystals again exist along the (100)(Cu). These platelet crystals are bound by macrosteps, and they are the growth sites. The morphology of electrolytic copper foils on the titanium substrate does not change with higher current densities and stirring rates. It was also found that chloride changes deposit orientations in the concentration range of less than 10 ppm. (C) 2004 The Electrochemical Society.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MurakamiHaruo en-aut-sei=Murakami en-aut-mei=Haruo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=sulfate kn-keyword=sulfate en-keyword=copper kn-keyword=copper en-keyword=baths kn-keyword=baths END start-ver=1.4 cd-journal=joma no-vol=148 cd-vols= no-issue=3 article-no= start-page=145 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200103 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Shape evolution of electrodeposited bumps into deep cavities en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Metal posts and finer pitch solder bumps are the indispensable microconnectors for chip size packaging and are formed by electrodeposition into deep cavities. It is difficult to stir inside these deep cavities. Natural convection due to density difference is effective in stirring inside cavity with 200 mum cathode width of aspect ratio of one. The bump shape increases toward lower side in a vertical cathode arrangement with placement angle of Theta = 90 degrees. This increase in bump height results from a collision of flow along the lower side of the resist sidewall which enlarges local current and thickens the lower edge of bumps. The effect of natural convection is also evident in the neighboring two cavities of 200 mum cathode width. The natural convection is not effective for cavities with less than 100 mum cathode width. The bump shapes become flat. Only diffusion occurs within these smaller than 100 mum cavities. (C) 2001 The Electrochemical Society. All rights reserved.

en-copyright= kn-copyright= en-aut-name=HayashiK en-aut-sei=Hayashi en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiKeisuke en-aut-sei=Fukui en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaZenzo en-aut-sei=Tanaka en-aut-mei=Zenzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Himeji Institute of Technology affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=copper bumps kn-keyword=copper bumps END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=3-4 article-no= start-page=233 end-page=239 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20064 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elucidation of the role of the complex in hydride transfer reaction between methylene blue and 1-benzyl-1,4-dihydronictinamide by effect of γ-cyclodextrin en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The kinetics of the hydride transfer reaction between Methylene Blue (MB+) and　1-benzyl-1,4-dihydronicotinamide (BNAH) were studied in 10 % ethanol-90 % water mixed solvents containing β- and γ-cyclodextrins (β-CD and γ-CD). The pseudo-first order rate constant shows kinetic saturation at high initial concentration of BNAH. This indicates the formation of a complex between MB+ and BNAH. The reaction was suppressed by addition of β-CD, but enhanced by addition of γ-CD. MB+ and BNAH were separately accommodated within the β-CD cavity and the cavity walls may protect the activity site of the reactants. On the other hand, in the MB+-BNAH-γ-CD system, the inclusion of the complex between MB+ and BNAH with γ-CD occurred. This effect of γ-CD can distinguish between the productive and non-productive nature of the complex.

en-copyright= kn-copyright= en-aut-name=LiuYingin en-aut-sei=Liu en-aut-mei=Yingin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HotouchiNaoto en-aut-sei=Hotouchi en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SueishiYoshimi en-aut-sei=Sueishi en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoShunzo en-aut-sei=Yamamoto en-aut-mei=Shunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=hydride transfer reaction kn-keyword=hydride transfer reaction en-keyword=reaction mechanism kn-keyword=reaction mechanism en-keyword=cyclodextrin kn-keyword=cyclodextrin en-keyword=inclusion complexes kn-keyword=inclusion complexes en-keyword=1-benzyl-1 kn-keyword=1-benzyl-1 en-keyword=4-dihydronicotinamide kn-keyword=4-dihydronicotinamide en-keyword=Methylene Blue kn-keyword=Methylene Blue END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=14 article-no= start-page=145503 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20044 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bridging the gap between small clusters and nanodroplets: spectroscopic study and computer simulation of carbon dioxide solvated with helium atoms. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

High resolution infrared spectra of HeN?CO2 clusters with N up to about 20 have been studied in the region of the CO2 v3 fundamental band. The B rotational constant initially drops as expected for a normal molecule, reaching a minimum for N = 5. Its subsequent rise for N = 6 to 11 can be interpreted as the transition from a normal (though floppy) molecule to a quantum solvation regime. For N > 13, the B value becomes approximately constant with a value about 17% larger than that measured in much larger helium nanodroplets. Quantum Monte Carlo calculations of pure rotational spectra are in excellent agreement with the measured B in this size range, and complement the experimental study with detailed structural information. For larger cluster size (N = 30-50) the simulations show a clear sign of convergence towards the nanodroplet B value.

en-copyright= kn-copyright= en-aut-name=TangJian en-aut-sei=Tang en-aut-mei=Jian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=McKellarRobert A en-aut-sei=McKellar en-aut-mei=Robert A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MezzacapoFabio en-aut-sei=Mezzacapo en-aut-mei=Fabio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoroniSaverio en-aut-sei=Moroni en-aut-mei=Saverio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Steacie Institute for Molecular Science affil-num=3 en-affil= kn-affil=Universit? di Roma La Sapienza affil-num=4 en-affil= kn-affil=Universit? di Roma La Sapienza en-keyword=infrared spectroscopy kn-keyword=infrared spectroscopy en-keyword=helium cluster kn-keyword=helium cluster en-keyword=molecular superfluidity kn-keyword=molecular superfluidity en-keyword=computer simulation kn-keyword=computer simulation END start-ver=1.4 cd-journal=joma no-vol=145 cd-vols= no-issue=3 article-no= start-page=840 end-page=844 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19983 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current evolution of electrodeposited copper bumps with photoresist angle en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We report the current distribution of copper bumps with photoresist sidewall angles. The role of outer diffusion, vortices, and penetration flow within the cavity is discussed, with numerical fluid dynamics computed in order to prevent side bumping. The current distributions were calculated at the diffusion controlled overpotential. The mass transfer-limited current distribution showed that a zero or negative angle reduced diffusion from the outer surroundings and enhanced vortex formation at the cathode corners. Reduction in the diffusion and enhancement in vortices reduced current at the cathode corners and prevented side bumping.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiKeisuke en-aut-sei=Fukui en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Himeji Institute of Technology en-keyword=shape evolution kn-keyword=shape evolution en-keyword=foil kn-keyword=foil en-keyword=transport kn-keyword=transport END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=11 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20059 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Infrared spectra of seeded hydrogen clusters: (para-H2)N-N2O and (ortho-H2)N-N2O, N=2-13 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

High-resolution infrared spectra of clusters containing para-H2 and/or ortho-H2 and a single nitrous oxide molecule are studied in the 2225-cm?1 region of the 1 fundamental band of N2O. The clusters are formed in pulsed supersonic jet expansions from a cooled nozzle and probed using a tunable infrared diode laser spectrometer. The simple symmetric rotor-type spectra generally show no resolved K structure, with prominent Q-branch features for ortho-H2 but not para-H2 clusters. The observed vibrational shifts and rotational constants are reported. There is no obvious indication of superfluid effects for para-H2 clusters up to N=13. Sharp transitions due to even larger clusters are observed, but no definite assignments are possible. Mixed (para-H2)N?(ortho-H2)M?N2O cluster line positions can be well predicted by linear interpolation between the corresponding transitions of the pure clusters.

en-copyright= kn-copyright= en-aut-name=TangJian en-aut-sei=Tang en-aut-mei=Jian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=McKellarRobert A en-aut-sei=McKellar en-aut-mei=Robert A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Steacie Institute for Molecular Science en-keyword=vibrational kn-keyword=vibrational en-keyword=rotational kn-keyword=rotational en-keyword=infrared spectroscopy kn-keyword=infrared spectroscopy en-keyword=gas phase kn-keyword=gas phase en-keyword=superfluidity kn-keyword=superfluidity END start-ver=1.4 cd-journal=joma no-vol=151 cd-vols= no-issue=4 article-no= start-page=250 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20042 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Role of additives for copper damascene electrodeposition experimental study on inhibition and acceleration effects en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The role of copper Damascene additives is discussed based on electrodeposit morphology on a through-mask cathode, field emission-Auger (FE-Auger), quartz crystal microbalance (QCM), and electrochemical measurements. Adsorbed particles, several tens of nanometers in diameter were observed on copper-electrodeposited surfaces by field emission-scanning electron microscopy (FE-SEM). These particles show a stronger oxygen intensity peak by FE-Auger spectrum than bare electrodeposited surfaces. The QCM frequency deviation did not increase with time in the CuSO4 and H2SO4 bath without polyethylene glycol (PEG) and chloride ion (Cl-) additives. When the substrates were immersed in the bath with these additives, the deviation markedly increased with time. Numerous PEG molecules were observed by FE-SEM immersed after 1000 s. The current density remained constant at a low value for the bath with PEG and Cl- additives. The current density started to increase markedly with time just after adding 1 ppm of bis(3-sulfopropyl) disulfide (SPS). Numerous PEG molecules were present on the electrodeposits before adding SPS. No PEG molecules, however, remained on the surface once SPS was added to the bath. The current density increased with narrower opening widths of the through-mask cathode. Despite this increase, the deposit cross sections on narrower opening widths of 2 and 10 mum were flat and no curvatures were found. Hence, the deposit curvature is not the origin of the acceleration effect. (C) 2004 The Electrochemical Society.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoToshiaki en-aut-sei=Matsumoto en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeKeiji en-aut-sei=Watanabe en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=polyethylene-glycol kn-keyword=polyethylene-glycol en-keyword=deposition kn-keyword=deposition END start-ver=1.4 cd-journal=joma no-vol=151 cd-vols= no-issue=7 article-no= start-page=514 end-page=518 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20046 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of cu-core pb-free solder bumps en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Cu-core Pb-free solder bumps were developed by electrodeposition in combination with photolithography. A bump with a pitch of 100 mum and a diam of 50 mum was successfully achieved with dry film resist (80 mum thick) under optimum process conditions, and the bumps reached the target height of 50 6 5 mm. The adoption of a dummy pattern improved the height uniformity of the bumps. Pull test results showed that the shear strength of the Cu bump (around 45 gf) was obtained by the soft-etching pretreatment of the Cu foil surface. Sn-Zn, Sn-Ag, Sn-Cu, and Sn-Bi platings were deposited as Pb-free solders with near-eutectic compositions. In particular, the interface properties of Sn-Zn solder plating/Cu were investigated after reflowing in this study, as well as the effect of Ni plating as an under ball metallurgy layer on compound formation at the interface. It was found that a compound of Y-Cu5Zn8 layer existed in the interface of the reflowed Sn-Zn plating/Cu. The Ni plating layer inhibited the formation of the interface Y-Cu5Zn8 compound with reflowing. (C) 2004 The Electrochemical Society.

en-copyright= kn-copyright= en-aut-name=MuDaobin en-aut-sei=Mu en-aut-mei=Daobin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaJunpei en-aut-sei=Maeda en-aut-mei=Junpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=electrodeposited copper bumps kn-keyword=electrodeposited copper bumps en-keyword=shape evolution kn-keyword=shape evolution en-keyword=lead kn-keyword=lead en-keyword=alloys kn-keyword=alloys END start-ver=1.4 cd-journal=joma no-vol=140 cd-vols= no-issue=2 article-no= start-page=362 end-page=365 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19932 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Codeposition of a-alumina particles from acid copper sulfate bath en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The purpose of this work is to elucidate the factors affecting the codeposition of a-alumina particles with copper from an acid copper sulfate bath. The effect of current density and particle concentration in the bath on the amount of codeposited a-alumina were determined. In order to evaluate the surface-chemical properties of the particles, the zeta-potential of a-alumina particles in the plating bath was determined by means of the streaming potential method. The amounts of adsorbed Cu 2+ and SO2( from the plating bath were also determined. The amount of codeposited a-alumina particles was found to be greater than those reported in literature, in spite of the negative zeta-potential values of a-alumina. This indicates that the electrostatic interaction between the particles and the cathode is not the essential factor of the codeposition process. It is considered that the amount of adsorbed Cu 2+ on the a-alumina particle plays an important role in the codeposition behavior.

en-copyright= kn-copyright= en-aut-name=HayashiHidetaka en-aut-sei=Hayashi en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IzumiShin-ya en-aut-sei=Izumi en-aut-mei=Shin-ya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TariIsao en-aut-sei=Tari en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=Deposition kn-keyword=Deposition en-keyword=Kinetics kn-keyword=Kinetics END start-ver=1.4 cd-journal=joma no-vol=152 cd-vols= no-issue=11 article-no= start-page=173 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High-aspect-ratio copper via filling used for three-dimensional chip stacking en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Through-chip electrodes for three-dimensional packaging can offer short interconnection and reduced signal delay. Formation of suitable vias by electrodeposition into cavities presents a filling problem similar to that encountered in the damascene process. Because via dimensions for through-chip filling are larger and have a higher aspect ratio relative to features in damascene, process optimization requires modification of existing superconformal plating baths and plating parameters. In this study, copper filling of high-aspect-ratio through-chip vias was investigated and optimized with respect to plating bath composition and applied current wavetrain. Void-free vias 70 mu m deep and 10 mu m wide were formed in 60 min using additives in combination with pulse-reverse current and dissolved-oxygen enrichment. The effects of reverse current and dissolved oxygen on the performance of superfilling additives is discussed in terms of their effects on formation, destruction, and distribution of a Cu(I) thiolate accelerant. (c) 2005 The Electrochemical Society. All rights reserved.

en-copyright= kn-copyright= en-aut-name=SunJian-Jun en-aut-sei=Sun en-aut-mei=Jian-Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamuraTakuji en-aut-sei=Okamura en-aut-mei=Takuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhSeungJin en-aut-sei=Oh en-aut-mei=SeungJin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomisakaManabu en-aut-sei=Tomisaka en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YonemuraHitoshi en-aut-sei=Yonemura en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HoshinoMasataka en-aut-sei=Hoshino en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakahashiKenji en-aut-sei=Takahashi en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Tsukuba Research Center affil-num=6 en-affil= kn-affil=Tsukuba Research Center affil-num=7 en-affil= kn-affil=Tsukuba Research Center affil-num=8 en-affil= kn-affil=Tsukuba Research Center en-keyword=plating baths kn-keyword=plating baths en-keyword=additives kn-keyword=additives END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=147 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Observation of micropores in hard-carbon using Xe-129 NMR porosimetry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The existence of micropores and the change of surface structure in pitch-based hard-carbon in xenon atmosphere were demonstrated using Xe-129 NMR. For high-pressure (4.0 MPa) Xe-129 NMR measurements, the hard-carbon samples in Xe gas showed three peaks at 27, 34 and 210 ppm. The last was attributed to the xenon in micropores (<1 nm) in hard-carbon particles. The NMR spectrum of a sample evacuated at 773 K and exposed to 0.1 MPa Xe gas at 773 K for 24 h showed two peaks at 29 and 128 ppm, which were attributed, respectively, to the xenon atoms adsorbed in the large pores (probably mesopores) and micropores of hard-carbon. With increasing annealing time in Xe gas at 773 K, both peaks shifted and merged into one peak at 50 ppm. The diffusion of adsorbed xenon atoms is very slow, probably because the transfer of molecules or atoms among micropores in hard-carbon does not occur readily. Many micropores are isolated from the outer surface. For that reason, xenon atoms are thought to be adsorbed only by micropores near the surface, which are easily accessible from the surrounding space.

en-copyright= kn-copyright= en-aut-name=GotohKazuma en-aut-sei=Gotoh en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UedaTakahiro en-aut-sei=Ueda en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmiHironori en-aut-sei=Omi en-aut-mei=Hironori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=EguchiTaro en-aut-sei=Eguchi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MaedaMariko en-aut-sei=Maeda en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyaharaMichihisa en-aut-sei=Miyahara en-aut-mei=Michihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AisakuNagai en-aut-sei=Aisaku en-aut-mei=Nagai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshidaHiroyuki en-aut-sei=Ishida en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=The Museum of Osaka University affil-num=3 en-affil= kn-affil=The Museum of Osaka University affil-num=4 en-affil= kn-affil=The Museum of Osaka University affil-num=5 en-affil= kn-affil=Research Center, Kureha Corporation affil-num=6 en-affil= kn-affil=Research Center, Kureha Corporation affil-num=7 en-affil= kn-affil=Research Center, Kureha Corporation affil-num=8 en-affil= kn-affil=Okayama University en-keyword=amorphous materials kn-keyword=amorphous materials en-keyword=microporous materials kn-keyword=microporous materials en-keyword=nuclear magnetic resonance (NMR) kn-keyword=nuclear magnetic resonance (NMR) END start-ver=1.4 cd-journal=joma no-vol=144 cd-vols= no-issue=2 article-no= start-page=466 end-page=470 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19972 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Shape evolution of electrodeposited copper bumps with high peclet numbers en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We report the shape evolution of initial copper bumps at Peclet numbers higher than a hundred. The role of vortices and of penetration flow within the cavity was discussed with numerical fluid dynamics computation to obtain a bump with a single hump at the center. The current distributions, or flux profiles, were calculated at the diffusion controlled overpotential and were compared with the electrodeposited bump shapes. For the 100 mu m cavity width, the vortices increase at the upstream corners with Peclet numbers 1410 and 7311. The vortices are the local resistance of mass transfer to the cathode. These vortices cause the hollows in flux profiles at the upstream corner with these Peclet numbers. The penetration flow collides with the photoresist sidewall and the vortices decrease at downstream corners. These decreased vortices cause the increase in flux profile at downstream corners. For a 30 pm cavity width a single large vortex forms for the higher Peclet number 44,500 and a single hump in flux is achieved.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiKeisuke en-aut-sei=Fukui en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YokoyamaMitsunori en-aut-sei=Yokoyama en-aut-mei=Mitsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShinoharaKunio en-aut-sei=Shinohara en-aut-mei=Kunio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Himeji Institute of Technology affil-num=3 en-affil= kn-affil=University of Hokkaido affil-num=4 en-affil= kn-affil=University of Hokkaido en-keyword=foil kn-keyword=foil en-keyword=transport kn-keyword=transport en-keyword=cavities kn-keyword=cavities END start-ver=1.4 cd-journal=joma no-vol=147 cd-vols= no-issue=7 article-no= start-page=2611 end-page=2613 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200007 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Electrodeposition of Zinc-SiO2 composite en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The incorporation mechanism of SiO2 particles into zinc electrodeposit is discussed. The SiO2 particles precipitate in two ways on the (00-1)(eta) of zinc electrodeposit: by lined up particles along the laterally growing macrosteps on the (00.1)(eta) and by randomly dispersed particles on the (00.1)(eta). These particles incorporate into the electrodeposits by following two processes. The sidewalls of particles are incorporated into the macrosteps at the edge of (00.1)(eta). The bottom of randomly dispersed particles are incorporated into the (00.1)(eta) probably by the atomic steps. (C) 2000 The Electrochemical Society.

en-copyright= kn-copyright= en-aut-name=KondoKazuo en-aut-sei=Kondo en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhgishiAtsufumi en-aut-sei=Ohgishi en-aut-mei=Atsufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaZennosuke en-aut-sei=Tanaka en-aut-mei=Zennosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=atomic-force microscopy kn-keyword=atomic-force microscopy en-keyword=iron binary alloy kn-keyword=iron binary alloy en-keyword=zinc kn-keyword=zinc en-keyword=morphology microstructure kn-keyword=morphology microstructure END start-ver=1.4 cd-journal=joma no-vol=140 cd-vols= no-issue=2 article-no= start-page=386 end-page=389 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19932 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Studies on the acid-base properties of the ZnBr2NaBr molten salt system en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The acid-base properties of the ZnBr2-NaBr melts at 623 K were investigated on the basis of the electromotive force measurements of a zinc-zinc concentration cell. The following two chemical equilibria were postulated to describe the acid-base character of the melts.

en-copyright= kn-copyright= en-aut-name=HayashiHidetaka en-aut-sei=Hayashi en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UnoKiyofumi en-aut-sei=Uno en-aut-mei=Kiyofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakeharaZen-ichiro en-aut-sei=Takehara en-aut-mei=Zen-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatagiriAkira en-aut-sei=Katagiri en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Kyoto University affil-num=3 en-affil= kn-affil=Kyoto University affil-num=4 en-affil= kn-affil=Kyoto University en-keyword=alcl3-nacl melts kn-keyword=alcl3-nacl melts en-keyword=equilibria kn-keyword=equilibria END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20059 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Electron- and neutrino-nucleus scattering in the impulse approximation regime en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A quantitative understanding of the weak nuclear response is a prerequisite for the analyses of neutrino experiments such as K2K and MiniBOONE, which measure energy and angle of the muons produced in neutrino-nucleus interactions in the energy range 0.5-3 GeV and reconstruct the incident neutrino energy to determine neutrino oscillations. In this paper we discuss theoretical calculations of electron- and neutrino-nucleus scattering, carried out within the impulse approximation scheme using realistic nuclear spectral functions. Comparison between electron scattering data and the calculated inclusive cross section of oxygen, at beam energies ranging between 700 and 1200 MeV, show that the Fermi gas model, widely used in the analysis of neutrino oscillation experiments, fails to provide a satisfactory description of the measured cross sections, and inclusion of nuclear dynamics is needed.

en-copyright= kn-copyright= en-aut-name=BenherOmar en-aut-sei=Benher en-aut-mei=Omar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FarinaNicola en-aut-sei=Farina en-aut-mei=Nicola kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraHiroki en-aut-sei=Nakamura en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakudaMakoto en-aut-sei=Sakuda en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekiRyoichi en-aut-sei=Seki en-aut-mei=Ryoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Ist Nazl Fis Nucl affil-num=2 en-affil= kn-affil=University of Roma La Sapienza affil-num=3 en-affil= kn-affil=Waseda University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=California State University en-keyword=monte-carlo calculations kn-keyword=monte-carlo calculations en-keyword=spectal-function kn-keyword=spectal-function en-keyword=proton propagation kn-keyword=proton propagation en-keyword=e kn-keyword=e en-keyword=e'p kn-keyword=e'p en-keyword=peactions kn-keyword=peactions en-keyword=cross-section kn-keyword=cross-section en-keyword=light-nucle? kn-keyword=light-nucle? en-keyword=matter kn-keyword=matter en-keyword=o-16 kn-keyword=o-16 en-keyword=transparency kn-keyword=transparency en-keyword=oscillation kn-keyword=oscillation END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20063 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Search for anomalous couplings in top decay at hadron colliders en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We present a quantitative study on sensitivities to the top-decay anomalous couplings, taking into account realistic experimental conditions expected at Tevatron and LHC. A double angular distribution of W and charged lepton in the top-decay is analyzed, using t<(t)<($)over bar> events in the leptons+jets channel. In order to improve sensitivities to the anomalous couplings, we apply two techniques: (i) We use a likelihood fitting method for full kinematical reconstruction of each top event. (ii) We develop a new effective spin reconstruction method for leptonically-decayed top quarks; this method does not require spin information of the antitop side. For simplicity, we neglect couplings of right-handed bottom quark as well as CP violating couplings. The 95% C.L. estimated bound on a ratio of anomalous couplings reads -0.81 < f(2)/f(1)<-0.70, -0.12 < f(2)/f(1)< 0.14 using 1000 reconstructed top events at Tevatron, while -0.74 < f(2)/f(1)<-0.72, -0.01 < f(2)/f(1)< 0.01 is expected with 100 k reconstructed top events at LHC, where only statistical errors are taken into account. A two-fold ambiguity in the allowed range remains when the number of events exceeds a few hundred.

en-copyright= kn-copyright= en-aut-name=TsunoS en-aut-sei=Tsuno en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanoI en-aut-sei=Nakano en-aut-mei=I kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaR en-aut-sei=Tanaka en-aut-mei=R kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=quark pair production kn-keyword=quark pair production en-keyword=order qcd correction kn-keyword=order qcd correction en-keyword=spin correlations kn-keyword=spin correlations en-keyword=linear kn-keyword=linear en-keyword=colliders kn-keyword=colliders en-keyword=charged leptons kn-keyword=charged leptons en-keyword=width kn-keyword=width en-keyword=thvatron kn-keyword=thvatron en-keyword=collisions kn-keyword=collisions en-keyword=threshold kn-keyword=threshold END start-ver=1.4 cd-journal=joma no-vol=456 cd-vols= no-issue=4 article-no= start-page=687 end-page=691 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080626 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress, a number of plasma membrane-type aquaporins were down-regulated, which can prevent continuous dehydration resulting in cell death. The leaves of transgenic rice plants that expressed the largest amount of HvPIP2;1 showed a 40% increase in internal CO2 conductance compared with leaves of wild-type rice plants. The rate of CO2 assimilation also increased in the transgenic plants. The goal of our plant aquaporin research is to determine the key aquaporin species responsible for water and CO2 transport, and to improve plant water relations, stress tolerance, CO2 uptake or assimilation, and plant productivity via molecular breeding of aquaporins.

en-copyright= kn-copyright= en-aut-name=KatsuharaMaki en-aut-sei=Katsuhara en-aut-mei=Maki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanbaYuko T. en-aut-sei=Hanba en-aut-mei=Yuko T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Research Institute for Bioresources, Okayama University affil-num=2 en-affil= kn-affil=Center for Bioresource Field Science, Kyoto Institute of Technology en-keyword=barley kn-keyword=barley en-keyword=CO2 kn-keyword=CO2 en-keyword=plant aquaporins kn-keyword=plant aquaporins en-keyword=salt stress kn-keyword=salt stress en-keyword=water transport kn-keyword=water transport END start-ver=1.4 cd-journal=joma no-vol=353 cd-vols= no-issue=1-2 article-no= start-page=28 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080529 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To evaluate the effect of coupling of recombinant human serum albumin (rHSA) onto the surface of poly(ethylene glycol)-modified liposorne (PEG liposome) on the in vivo disposition characteristics of liposomal doxorubicin (DXR), the pharmacokinetics and tissue distribution of DXR were evaluated after intravenous administration of rHSA-modified PEG (rHSA/PEG) liposomal DXR into tumor-bearing rats. rHSA/PEG liposome prepared using a hetero-bifunctional cross-linker, N- succinimidyl 3-(2-pyridyldithio) propionate (SPDP), efficiently encapsulated DXR (over 95%). rHSA/PEG liposomal DXR showed longer blood-circulating property than PEG liposornal DXR and the hepatic and splenic clearances of rHSA/PEG liposornal DXR were significantly smaller than those of PEG liposomal DXR. It was also demonstrated that the disposition of DXR to the heart, one of the organs for DXR-related side-effects, was significantly smaller than free DXR. Furthermore, the tumor accumulation of rHSA/PEG liposomal DXR was significantly larger than that of PEG liposomal DXR. The "therapeutic index", a criterion for therapeutic outcome, for rHSA/PEG fiposornal DXR was significantly higher than PEG liposomal DXR. These results clearly indicate that rHSA-conjugation onto the surface of PEG liposome would be a useful approach to increase the effectiveness and safety of PEG liposomal DXR.

en-copyright= kn-copyright= en-aut-name=YokoeJun-ichi en-aut-sei=Yokoe en-aut-mei=Jun-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakuragiShiho en-aut-sei=Sakuragi en-aut-mei=Shiho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamotoKayoko en-aut-sei=Yamamoto en-aut-mei=Kayoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TeragakiTakuya en-aut-sei=Teragaki en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OgawaraKen-ichi en-aut-sei=Ogawara en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HigakiKazutaka en-aut-sei=Higaki en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KatayamaNaohisa en-aut-sei=Katayama en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KaiToshiya en-aut-sei=Kai en-aut-mei=Toshiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatoMakoto en-aut-sei=Sato en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KimuraToshikiro en-aut-sei=Kimura en-aut-mei=Toshikiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=2 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=3 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=4 en-affil= kn-affil=Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=bDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University affil-num=7 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=8 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=9 en-affil= kn-affil=Pharmaceutical Research Division, NIPRO Corporation affil-num=10 en-affil= kn-affil=Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University en-keyword=Recombinant human serum albumin (rHSA) kn-keyword=Recombinant human serum albumin (rHSA) en-keyword=PEG liposome kn-keyword=PEG liposome en-keyword=Doxorubicin kn-keyword=Doxorubicin en-keyword=Tumor-bearing rats kn-keyword=Tumor-bearing rats en-keyword=Passive targeting kn-keyword=Passive targeting END start-ver=1.4 cd-journal=joma no-vol=343 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080522 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To clarify to what extent topically administered drug molecules horizontally permeate into tissues surrounding the administration site, the intramuscular lateral concentration profile of acetaminophen was investigated in vivo using the microdialysis method in rats. When acetaminophen was intramuscularly administered for 6 hr in a pinpoint manner at a constant rate of 3 μg/min, it was clearly detected in the muscle surrounding the administration site, being 17.5 μg/ml when measured at a 2 mm distance from the administration site. The concentration in the muscle was decreased as the distance increased, and those measured at 5 mm and 40 mm were 0.35 μg/ml and 0.09 μg/ml, respectively. In addition, it was shown that the concentration in the muscle at 40 mm reflected the compoundfs concentration in plasma, but not the compoundfs horizontal permeation from the administration site. With these observations, the intramuscular distribution profile of acetaminophen was numerically characterized according to Fickfs law. As a result, it was revealed that horizontal permeation is the primary process accountable for the increased intramuscular concentration only in the area adjacent to the administration site, and the radius of the adjacent area was calculated to be 5.80 mm for acetaminophen.

en-copyright= kn-copyright= en-aut-name=KurosakiYuji en-aut-sei=Kurosaki en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TagawaMasahiro en-aut-sei=Tagawa en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmotoAkiho en-aut-sei=Omoto en-aut-mei=Akiho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuitoHiroshi en-aut-sei=Suito en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomoriYukiko en-aut-sei=Komori en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AibaTetsuya en-aut-sei=Aiba en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Environmental Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=7 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=Microdialysis kn-keyword=Microdialysis en-keyword=Intramuscular concentration profile kn-keyword=Intramuscular concentration profile en-keyword=Drug disposition kn-keyword=Drug disposition en-keyword=Acetaminophen kn-keyword=Acetaminophen en-keyword=Pharmacokinetics kn-keyword=Pharmacokinetics en-keyword=Drug delivery kn-keyword=Drug delivery END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=8 article-no= start-page=887 end-page=893 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Generation of active fragments from human zymogens in the bradykinin-generating cascade by extracellular proteases from Vibrio vulnificus and V. parahaemolyticus en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Vibrio vulnificus is an opportunistic human pathogen causing septicemia, and the infection is characterized by formation of the edematous skin lesions on limbs. This pathogenic species secretes a thermolysin-like metalloprotease as a virulence determinant. The metalloprotease was confirmed to activate human factor XII-plasma kallikrein-kinin cascade that results in liberation of bradykinin, a chemical mediator enhancing the vascular permeability, from high-molecular weight kininogen. Namely, the metalloprotease showed to generate active fragments by cleavage of Arg-Ile, Arg-Val or Gly-Leu peptide bond in human zymogens (plasma prekallikrein and factor XII). In spite of induction of the sufficient vascular permeability-enhancing and edema-forming reaction in the guinea pig model, a serine protease from V. parahaemolyticus, a human pathogen causing primarily watery diarrhea, showed far less ability to activate and to cleave the human zymogens. These results in part may explain why only V. vulnificus often causes serious edematous skin damages in humans.

en-copyright= kn-copyright= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeHirofumi en-aut-sei=Watanabe en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawaseTomoka en-aut-sei=Kawase en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaHidenori en-aut-sei=Yamada en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShinodaSumio en-aut-sei=Shinoda en-aut-mei=Sumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=vibrio vulnificus kn-keyword=vibrio vulnificus en-keyword=vibrio parahaemolyticus kn-keyword=vibrio parahaemolyticus en-keyword=protease kn-keyword=protease en-keyword=factor XII kn-keyword=factor XII en-keyword=plasma prekallikrein kn-keyword=plasma prekallikrein END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=3 article-no= start-page=508 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction of cytolytic activity and interferon-gamma production in murine natural killer cells by polymyxins B and E en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Natural killer (NK) cells are the primary effector cells of the innate immune system and have well-established roles in tumor rejection and resistance to viruses, bacteria and certain parasites. There is a need for more specific immune modulators of NK cell activity that tack the wide-ranging side effects of NK cell-stimulatory interleukins. The polycationic antibiotic polymyxin B (PMB) has been shown to have a unique ability to enhance activities of some immune cells, independent of its antibiotic properties. Here we report that both PMB and its analog potymyxin E (PME) markedly enhanced the activity of NK cells enriched from the murine spleen. Maximal activation of NK cell activity was obtained after 24 h of incubation with PMB at a dose of 300 mu g/ml. PMB nonapeptide, one of the two PMB domains, and PME methanesulfonate, the negatively charged derivative of PME, had little effect on NK cell activity. PMB induced interferon (IFN)-gamma and tumor necrosis factor-a production in NK cells. Proliferation of NK cells in vitro was significantly stimulated by being incubated with PMB. Administration of PMB to mice for 7 consecutive days stimulated splenic NK cell activity and increased NK cell populations in the spleen. These results suggest that the polycationic antibiotics PMB and PME may up-regulate innate and adaptive immune responses by induction of NK cell activity and IFN-gamma production.

en-copyright= kn-copyright= en-aut-name=ZhongMing en-aut-sei=Zhong en-aut-mei=Ming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KadotaYusuke en-aut-sei=Kadota en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimizuYoshio en-aut-sei=Shimizu en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GohdaEiichi en-aut-sei=Gohda en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Bizen Chemical Co., Ltd affil-num=4 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=polymyxin B (PMB) kn-keyword=polymyxin B (PMB) en-keyword=polymyxin E (PME) kn-keyword=polymyxin E (PME) en-keyword=NK cells kn-keyword=NK cells en-keyword=IFN-gamma kn-keyword=IFN-gamma END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=23 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Opacity effect on extreme ultraviolet radiation from laser-produced tin plasmas en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Opacity effects on extreme ultraviolet (EUV) emission from laser-produced tin (Sn) plasma have been experimentally investigated. An absorption spectrum of a uniform Sn plasma generated by thermal x rays has been measured in the EUV range (9-19 nm wavelength) for the first time. Experimental results indicate that control of the optical depth of the laser-produced Sn plasma is essential for obtaining high conversion to 13.5 nm-wavelength EUV radiation; 1.8% of the conversion efficiency was attained with the use of 2.2 ns laser pulses.

en-copyright= kn-copyright= en-aut-name=FujiokaShinsuke en-aut-sei=Fujioka en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraHiroaki en-aut-sei=Nishimura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiharaKatsunobu en-aut-sei=Nishihara en-aut-mei=Katsunobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SunaharaAtsushi en-aut-sei=Sunahara en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkunoTomoharu en-aut-sei=Okuno en-aut-mei=Tomoharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UedaNobuyoshi en-aut-sei=Ueda en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AndoTsuyoshi en-aut-sei=Ando en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TaoYezheng en-aut-sei=Tao en-aut-mei=Yezheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShimadaYoshinori en-aut-sei=Shimada en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HashimotoKazuhisa en-aut-sei=Hashimoto en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamauraMichiteru en-aut-sei=Yamaura en-aut-mei=Michiteru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ShigemoriKeisuke en-aut-sei=Shigemori en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NakaiMitsuo en-aut-sei=Nakai en-aut-mei=Mitsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NagaiKeiji en-aut-sei=Nagai en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=NorimatsuTakayoshi en-aut-sei=Norimatsu en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=NishikawaTakeshi en-aut-sei=Nishikawa en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=MiyanagaNoriaki en-aut-sei=Miyanaga en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=IzawaYasukazu en-aut-sei=Izawa en-aut-mei=Yasukazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=MimaKunioki en-aut-sei=Mima en-aut-mei=Kunioki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil= kn-affil=Osaka University affil-num=2 en-affil= kn-affil=Osaka University affil-num=3 en-affil= kn-affil=Osaka University affil-num=4 en-affil= kn-affil=Advanced Photon Research Center affil-num=5 en-affil= kn-affil=Institute for Laser Technology affil-num=6 en-affil= kn-affil=Osaka University affil-num=7 en-affil= kn-affil=Osaka University affil-num=8 en-affil= kn-affil=Osaka University affil-num=9 en-affil= kn-affil=Osaka University affil-num=10 en-affil= kn-affil=Institute for Laser Technology affil-num=11 en-affil= kn-affil=Institute for Laser Technology affil-num=12 en-affil= kn-affil=Institute for Laser Technology affil-num=13 en-affil= kn-affil=Osaka University affil-num=14 en-affil= kn-affil=Osaka University affil-num=15 en-affil= kn-affil=Osaka University affil-num=16 en-affil= kn-affil=Osaka University affil-num=17 en-affil= kn-affil=Okayama University affil-num=18 en-affil= kn-affil=Osaka University affil-num=19 en-affil= kn-affil=Osaka University affil-num=20 en-affil= kn-affil=Osaka University en-keyword=emission kn-keyword=emission en-keyword=targets kn-keyword=targets en-keyword=lithography kn-keyword=lithography en-keyword=fusion kn-keyword=fusion END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=14 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20054 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Observation of the acceleration of a single bunch by using the induction device in the kek proton synchrotron en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A single rf bunch in the KEK proton synchrotron was accelerated with an induction acceleration method from the injection energy of 500 MeV to 5 GeV.

en-copyright= kn-copyright= en-aut-name=TakayamaKen en-aut-sei=Takayama en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KosekiKunio en-aut-sei=Koseki en-aut-mei=Kunio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TorikaiKota en-aut-sei=Torikai en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TokuchiAkira en-aut-sei=Tokuchi en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraEiji en-aut-sei=Nakamura en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ArakidaYoshio en-aut-sei=Arakida en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShimosakiYoshito en-aut-sei=Shimosaki en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WakeMasayoshi en-aut-sei=Wake en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KounoTadaaki en-aut-sei=Kouno en-aut-mei=Tadaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HoriokaKazuhiko en-aut-sei=Horioka en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IgarashiSusumu en-aut-sei=Igarashi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IwashitaTaiki en-aut-sei=Iwashita en-aut-mei=Taiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KawasakiAtsushi en-aut-sei=Kawasaki en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KishiroJun-ichi en-aut-sei=Kishiro en-aut-mei=Jun-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=SakudaMakoto en-aut-sei=Sakuda en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=SatoHikaru en-aut-sei=Sato en-aut-mei=Hikaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=ShihoMakoto en-aut-sei=Shiho en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=ShirakataMasashi en-aut-sei=Shirakata en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=SuenoTsuyoshi en-aut-sei=Sueno en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=ToyamaTakeshi en-aut-sei=Toyama en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=WatanabeMasao en-aut-sei=Watanabe en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=YamaneIsao en-aut-sei=Yamane en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= affil-num=1 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=2 en-affil= kn-affil=Graduate University for Advanced Studies affil-num=3 en-affil= kn-affil=Kyushu University affil-num=4 en-affil= kn-affil=Nichicon Corporation affil-num=5 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=6 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=7 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=8 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=9 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=10 en-affil= kn-affil=Tokyo Institute of Technology affil-num=11 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=12 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=13 en-affil= kn-affil=Nichicon Corporation affil-num=14 en-affil= kn-affil=Japan Atomic Energy Research Institute affil-num=15 en-affil= kn-affil=Okayama University affil-num=16 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=17 en-affil= kn-affil=Japan Atomic Energy Research Institute affil-num=18 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=19 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=20 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK affil-num=21 en-affil= kn-affil=Japan Atomic Energy Research Institute affil-num=22 en-affil= kn-affil=High Energy Accelerator Research Organization, KEK END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=22 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Electronic structure and spontaneous internal field around nonmagnetic impurities in spin-triplet chiral p-wave superconductors en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The electronic structure around an impurity in spin-triplet p-wave superconductors is studied by the Bogoliubov-de Gennes theory on a tight-binding model, where we have chosen sin p(x)+i sin p(y)-wave or sin(p(x)+p(y))+i sin(-p(x)+p(y))-wave states, which are considered to be candidates for the pairing state in Sr2RuO4. We calculate the spontaneous current and the local density of states around the impurity and discuss the difference between the two types of pairing. We propose that it is possible to discriminate the two pairing states by studying the spatial dependence of the magnetic field around a pair of impurities.

en-copyright= kn-copyright= en-aut-name=TakigawaMitsuaki en-aut-sei=Takigawa en-aut-mei=Mitsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IchiokaMasanori en-aut-sei=Ichioka en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurokiKazuhiko en-aut-sei=Kuroki en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaYukio en-aut-sei=Tanaka en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Hokkaido University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=University of Electro-Communications affil-num=4 en-affil= kn-affil=Nagoya University en-keyword=unconventional superconductors kn-keyword=unconventional superconductors en-keyword=sr2ru04 kn-keyword=sr2ru04 en-keyword=states kn-keyword=states en-keyword=scattering kn-keyword=scattering en-keyword=junction kn-keyword=junction en-keyword=shift kn-keyword=shift en-keyword=phase kn-keyword=phase en-keyword=model kn-keyword=model en-keyword=gap kn-keyword=gap END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=6 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070814 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Line and boundary tensions on approach to the wetting transition en-subtitle= kn-subtitle= en-abstract= kn-abstract=A mean-field density-functional model often used in the past in the study of line and boundary tensions at wetting and prewetting transitions is reanalyzed by extensive numerical calculations, approaching the wetting transition much more closely than had previously been possible. The results are what are now believed to be definitive for the model. They include strong numerical evidence for the presence of the logarithmic factors predicted by theory both in the mode of approach of the prewetting line to the triple-point line at the point of the first-order wetting transition and in the line tension itself on approach to that point. It is also demonstrated with convincing numerical precision that the boundary tension on the prewetting line and the line tension on the triple-point line have a common limiting value at the wetting transition, again as predicted by theory. As a by product of the calculations, in the model's symmetric three-phase state, far from wetting, it is found that certain properties of the model's line tension and densities are almost surely given by simple numbers arising from the symmetries, but proving that these are exact for the model remains a challenge to analytical theory. en-copyright= kn-copyright= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WidomB. en-aut-sei=Widom en-aut-mei=B. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Baker Laboratory, Cornell University en-keyword=SURFACE PHASES kn-keyword=SURFACE PHASES en-keyword=FLUID PHASES kn-keyword=FLUID PHASES en-keyword=SUBSTRATE kn-keyword=SUBSTRATE en-keyword=ADSORPTION kn-keyword=ADSORPTION en-keyword=INTERFACE kn-keyword=INTERFACE en-keyword=CONTACT kn-keyword=CONTACT en-keyword=MODEL kn-keyword=MODEL en-keyword=ICE kn-keyword=ICE END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=6 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20052 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Anisotropic diamagnetic response in type-II superconductors with gap and fermi-surface anisotropies en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The effects of anisotropic gap structures on a diamagnetic response are investigated in order to demonstrate that the field-angle-resolved magnetization [M-L (chi)] measurement can be used as a spectroscopic method to detect gap structures. Our microscopic calculation based on the quasiclassical Eilenberger formalism reveals that M-L (chi) in a superconductor with a fourfold gap displays a fourfold oscillation reflecting the gap and Fermi-surface anisotropies, and the sign of this oscillation changes at a field between H-c1 and H-c2. As a prototype of unconventional superconductors, magnetization data for borocarbides are also discussed.

en-copyright= kn-copyright= en-aut-name=AdachiH en-aut-sei=Adachi en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiranovicP en-aut-sei=Miranovic en-aut-mei=P kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchiokaM en-aut-sei=Ichioka en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=University of Montenegro affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=ginzburg-landau equations kn-keyword=ginzburg-landau equations en-keyword=density-of-states kn-keyword=density-of-states en-keyword=virial-theorem kn-keyword=virial-theorem en-keyword=magnetization kn-keyword=magnetization en-keyword=dependence kn-keyword=dependence en-keyword=symmetry kn-keyword=symmetry en-keyword=luni2b2c kn-keyword=luni2b2c en-keyword=yni2b2c kn-keyword=yni2b2c END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=22 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20056 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Metallic phase in the metal-intercalated higher fullerene Rb8.8(7)C84 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A new material of higher fullerene, RbxC84, was synthesized by intercalating Rb metal into C-84 crystals. The RbxC(84) crystals showed a simple cubic (sc) structure with lattice constant, a, of 16.82 (2) angstrom at 6.5 K, and 16.87 (2) angstrom at 295 K. The Rietveld refinements were achieved with the space group, Pa (3) over bar, based on a model that the C-2 axis of D2d-C84 aligned along [111]. The sample composition was determined to be Rb-8.8(7) C-84. The ESR spectrum at 303 K was composed of a broad peak with peak-to-peak linewidth Delta H-pp of 220 G, and a narrow peak with Delta H-pp of 24 G. Temperature dependence of the broad peak clearly showed a metallic behavior. The metallic behavior was discussed based on a theoretical calculation. This finding of new metallic phase in a higher fullerene is the first step for a development of new types of fullerene materials with novel physical properties such as superconductivity.

en-copyright= kn-copyright= en-aut-name=RikiishiYoshie en-aut-sei=Rikiishi en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KashinoYoko en-aut-sei=Kashino en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KusaiHaruka en-aut-sei=Kusai en-aut-mei=Haruka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakabayashiYasuhiro en-aut-sei=Takabayashi en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuwaharaEiji en-aut-sei=Kuwahara en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakenobuTaishi en-aut-sei=Takenobu en-aut-mei=Taishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IwasaYoshihiro en-aut-sei=Iwasa en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MizorogiNaomi en-aut-sei=Mizorogi en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NagaseShigeru en-aut-sei=Nagase en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OkadaSusumu en-aut-sei=Okada en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=6 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=7 en-affil= kn-affil=Department of Physics, Okayama University affil-num=8 en-affil= kn-affil=CREST, Japan Science and Technology Agency affil-num=9 en-affil= kn-affil=CREST, Japan Science and Technology Agency affil-num=10 en-affil= kn-affil=Institute for Molecular Science affil-num=11 en-affil= kn-affil=Institute for Molecular Science affil-num=12 en-affil= kn-affil=Institute of Physics and Center for Computational Science, University of Tsukuba END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Annealing effects on the magnetic and structural properties of single-crystal TDAE-C-60 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Annealing effects on the magnetic and structural properties of single-crystal TDAE-C-60 are investigated. When a crystal is well-annealed at 350 K, ferromagnetic ordering takes place below 16 K, though no magnetic phase transition is shown in as-grown crystal. The saturated magnetization was obtained to be 0.9+/-0.1 mu(B) per C-60. It was first found that the well-annealed crystal shows a structural phase transition around 180 K, probably associated with the orientational ordering of C-60 molecules. On the other hand, the as-grown crystal undergoes no structural phase transition at least down to 30 K while the motion of C-60 molecules is restricted below around 150 K. The possible relation between the low-temperature structure and the magnetic ordering is discussed.

en-copyright= kn-copyright= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NogamiYoshio en-aut-sei=Nogami en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaKokichi en-aut-sei=Oshima en-aut-mei=Kokichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=401 cd-vols= no-issue= article-no= start-page=218 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formation of low-resistivity region in p-Si substrate of SiGe/Si episystem by remote-hydrogen plasma treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have studied effects of hydrogen treatment on the resistivity profile of the SiGe/Si episystem by spreading resistance (SR) method. In this paper, we present experimental findings that hydrogen treatment reduces the resistivity at a specific part in the Si substrate region. This position was confirmed to be under the interface between SiGe and Si that emerged on the bevel surface during hydrogen treatment. We investigated the depth of resistivity-reduced regions which was formed by various hydrogenating conditions and found that the region was extended to the same depth as the penetration depth of hydrogen. We concluded that the low-resistivity region was formed under the influence of hydrogen introduced from bevel surface. We attributed this resistivity reduction to formation of some defects which originally existed at the interface and diffused into Si substrate with hydrogen.

en-copyright= kn-copyright= en-aut-name=YamashitaYoshifumi en-aut-sei=Yamashita en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamotoYoshifumi en-aut-sei=Sakamoto en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KamiuraYoichi en-aut-sei=Kamiura en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshiyamaTakeshi en-aut-sei=Ishiyama en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University en-keyword=SiGe/Si kn-keyword=SiGe/Si en-keyword=Hydroge. Resistivity reduction kn-keyword=Hydroge. Resistivity reduction en-keyword=Interface kn-keyword=Interface END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=6 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20062 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Resonant inelastic x-ray scattering at the oxygen k resonance of nio:nonlocal charge transfer and double-singlet excitations en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We report high-resolution polarization-dependent resonant inelastic x-ray scattering (RIXS) at the O K resonance of NiO showing a rich excitation spectrum. We perform multisite Ni6O19 cluster model calculations, revealing that solid state effects are substantial. We identify a nonlocal charge transfer excitation at 4-5 eV and double-singlet creation at 1.75 eV, both exhibiting significant scattering geometry dependence. Apart from an intense band of local charge transfer excitations (above 5 eV) also dd excitations at 1 eV are observed. Finally, we point out that O K RIXS of correlated metal oxides allows a quantitative and consistent determination of the charge transfer energy Delta and the Hund coupling energy J(H).

en-copyright= kn-copyright= en-aut-name=DudaL C en-aut-sei=Duda en-aut-mei=L C kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SchmittT en-aut-sei=Schmitt en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MangnusonM en-aut-sei=Mangnuson en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ForsbergJ en-aut-sei=Forsberg en-aut-mei=J kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OlssonA en-aut-sei=Olsson en-aut-mei=A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NordgrenJ. en-aut-sei=Nordgren en-aut-mei=J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkadaK en-aut-sei=Okada en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KotaniA en-aut-sei=Kotani en-aut-mei=A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Uppsala University affil-num=2 en-affil= kn-affil=Uppsala University affil-num=3 en-affil= kn-affil=Uppsala University affil-num=4 en-affil= kn-affil=Uppsala University affil-num=5 en-affil= kn-affil=Uppsala University affil-num=6 en-affil= kn-affil=Uppsala University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=High Energy Accelerator Research Organization en-keyword=transition-meal compounds kn-keyword=transition-meal compounds en-keyword=electronic-structure kn-keyword=electronic-structure en-keyword=raman-scattering kn-keyword=raman-scattering en-keyword=emission-spectroscopy kn-keyword=emission-spectroscopy en-keyword=spectra kn-keyword=spectra en-keyword=absorption kn-keyword=absorption en-keyword=coo kn-keyword=coo END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=17 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20055 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structural differences in two polymorphs of tetra-kis-(dimethylamino)-ethylene-C-60: An x-ray diffraction study en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A type of low-temperature structure for ferromagnetic alpha-tetra-kis (dimethylamino) -ethylene (TDAE)-C-60 is proposed on the basis of low-temperature x-ray analysis. We observed that intense superlattice reflections with odd indices successively appeared below T-s = 170 K. The space group symmetry of the low-temperature phase is determined to be P2(1)/n. Two inequivalent C-60 sites exist in the low-temperature phase, which are indispensable to the orbital ordering model Of C-60. The contact configuration for the neighboring C(60)s along the stacking c direction is uniquely determined. The double bond between the hexagons faces the neighboring pentagon. We found that the surrounding TDAE molecules shift along the c axis (similar to 0.07 angstrom) and that these shifts correlate perfectly to the alignment of C-60. This result indicates that the steric effect betwee n C-60 and TDAE molecules plays an important role in the orientational ordering Of C-60, On the other hand, in the alpha' phase, no structural phase transition was observed below 30 K. This indicates that all the C(60)s are crystallographically equivalent. Structural differences separate the magnetic peculiarities of the two polymorphs in TDAE-C-60.

en-copyright= kn-copyright= en-aut-name=FujiwaraMotoyasu en-aut-sei=Fujiwara en-aut-mei=Motoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaKokichi en-aut-sei=Oshima en-aut-mei=Kokichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=Physics kn-keyword=Physics en-keyword=Condensed Matter kn-keyword=Condensed Matter END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Competing spin phases in geometrically frustrated magnetic molecules en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We identify a class of zero-dimensional classical and quantum Heisenberg spin systems exhibiting anomalous behavior in an external magnetic field B similar to that found for the geometrically frustrated kagome lattice of classical spins. Our calculations for the isotropic Heisenberg model show the emergence of a pronounced minimum in the differential susceptibility dM/dB at B-sat/3 as the temperature T is raised from 0 K for structures based on corner-sharing triangles, specifically the octahedron, cuboctahedron, and icosidodecahedron. As the first experimental evidence we note that the giant Keplerate magnetic molecule {Mo72Fe30} (Fe3+ ions on the 30 vertices of an icosidodecahedron) exhibits this behavior. For low T when Bapproximate toB(sat)/3 two competing families of spin configurations exist of which one behaves magnetically "stiff" leading to a reduction of dM/dB.

en-copyright= kn-copyright= en-aut-name=SchroderChristian en-aut-sei=Schroder en-aut-mei=Christian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NojiriHiroyuki en-aut-sei=Nojiri en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SchnackJurgen en-aut-sei=Schnack en-aut-mei=Jurgen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HagePeter en-aut-sei=Hage en-aut-mei=Peter kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LubanMarshall en-aut-sei=Luban en-aut-mei=Marshall kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KogerlerPaul en-aut-sei=Kogerler en-aut-mei=Paul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=University of Applied Sciences Bielefeld affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Universitat Osnabruck affil-num=4 en-affil= kn-affil=Universitat Osnabruck affil-num=5 en-affil= kn-affil=Iowa State University affil-num=6 en-affil= kn-affil=Iowa State University en-keyword=antiferromagnet kn-keyword=antiferromagnet en-keyword=field kn-keyword=field en-keyword=lattice kn-keyword=lattice en-keyword=spheres kn-keyword=spheres en-keyword=state kn-keyword=state END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=13 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060407 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Close-packed structures and phase diagram of soft spheres in cylindrical pores en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is shown for a model system consisting of spherical particles confined in cylindrical pores that the first ten close-packed phases are in one-to-one correspondence with the first ten ways of folding a triangular lattice, each being characterized by a roll-up vector like the single-walled carbon nanotube. Phase diagrams in pressure-diameter and temperature-diameter planes are obtained by inherent-structure calculation and molecular dynamics simulation. The phase boundaries dividing two adjacent phases are infinitely sharp in the low-temperature limit but are blurred as temperature is increased. Existence of such phase boundaries explains rich, diameter-sensitive phase behavior unique for cylindrically confined systems. en-copyright= kn-copyright= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=WALLED CARBON NANOTUBES kn-keyword=WALLED CARBON NANOTUBES en-keyword=NANOCAPILLARITY kn-keyword=NANOCAPILLARITY en-keyword=MICROTUBULES kn-keyword=MICROTUBULES en-keyword=CAPILLARITY kn-keyword=CAPILLARITY en-keyword=CRYSTALS kn-keyword=CRYSTALS END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=10 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20049 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure and magnetic properties of the single-molecule magnet [Mn11CrO12(O2CCH3)(16)(H2O)(4)]center dot 2CH(3)COOH center dot 4H(2)O: magnetization manipulation and dipolar-biased tunneling in a Mn11Cr/Mn-12 mixed crystal en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The structural and magnetic properties of the single-molecule magnet [Mn11CrO12(O2CCH3)(16)(H2O)(4)].2CH(3)COOH.4H(2)O (Mn11Cr) are studied through the analysis of a Mn11Cr/Mn-12 (approximate to1:1) mixed crystal, where Mn-12 is [Mn12O12(O2CCH3)(16)(H2O)(4)].2CH(3)COOH.4H(2)O. X-ray absorption spectra reveal that the Cr ion in Mn11Cr is in the +3 valence state and occupies a specific Mn3+ site in the Mn-12 skeleton. High-frequency electron paramagnetic resonance (EPR) spectra are well explained by assuming that Mn11Cr is in a ground spin-state of S=19/2 with nearly the same EPR parameter set as for Mn-12. The lower spin quantum number results in lower barrier height (56.8 K) compared to Mn-12. The magnetization curves indicate a coercive field of 0.95 T for Mn11Cr at 1.8 K, nearly half that for Mn-12. Quantum tunneling of magnetization (QTM) in Mn11Cr is observed below the blocking temperature T-B, with the same field interval as for Mn-12. The magnetization of Mn11Cr and Mn-12 in the mixed crystal can be independently manipulated by utilizing the difference between their coercive fields. The resonance fields of QTM in Mn11Cr are significantly affected by the magnetization direction of Mn-12, suggesting the effect of dipolar-biased tunneling.

en-copyright= kn-copyright= en-aut-name=HachisukaHidekazu en-aut-sei=Hachisuka en-aut-mei=Hidekazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AwagaKunio en-aut-sei=Awaga en-aut-mei=Kunio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YokoyamaToshihiko en-aut-sei=Yokoyama en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KuboTakeji en-aut-sei=Kubo en-aut-mei=Takeji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotoTakao en-aut-sei=Goto en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NojiriHiroyuki en-aut-sei=Nojiri en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Nagoya University affil-num=2 en-affil= kn-affil=Nagoya University affil-num=3 en-affil= kn-affil=Institute for Molecular Sciences affil-num=4 en-affil= kn-affil=Nara University of Education affil-num=5 en-affil= kn-affil=Graduate School of Human and Environmental Studies affil-num=6 en-affil= kn-affil=Okayama University en-keyword=high-spin molecules kn-keyword=high-spin molecules en-keyword=jahn-teller isomerism kn-keyword=jahn-teller isomerism en-keyword=ground-state kn-keyword=ground-state en-keyword=mn-12 kn-keyword=mn-12 en-keyword=complexes kn-keyword=complexes en-keyword=relaxation kn-keyword=relaxation en-keyword=susceptibility kn-keyword=susceptibility en-keyword=mn12012(02cr)(16)(H20)(4) kn-keyword=mn12012(02cr)(16)(H20)(4) en-keyword=mn12012(02CR)16(h20)4 kn-keyword=mn12012(02CR)16(h20)4 en-keyword=cluster kn-keyword=cluster en-keyword=s=9 kn-keyword=s=9 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue=23 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19996 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Metal-insulator transition at 50 K in Na2C60 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Temperature dependence of electron spin resonance in Na2C60 was studied in a temperature range from 2 to 350 K. It was shown that Na2C60 was metallic above 50 K and had a metal-insulator transition at 50 K. The center frequency for the Hg(2) Raman mode in Na2C60 at 298 K was close to those in the metallic Rb3C60, K3C60, and Cs3C60, while the linewidth was close to that in the metallic but nonsuperconducting Cs3C60. The Hg(2) mode showed a large blueshift and narrowing at 50 K. The center frequency and the linewidth in the low-temperature region from 50 K were almost the same as those in the insulating C-60 and Rb6C60, which showed the metal-insulator transition at 50 K in Na2C60. The origin of this metal-insulator transition was discussed in terms of the electron-phonon interaction (Jahn-Teller effect) and the electron-electron interaction (Mott-Hubbard picture). [S0163-1829(99)04123-5].

en-copyright= kn-copyright= en-aut-name=KubozonoY. en-aut-sei=Kubozono en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakabayashiY. en-aut-sei=Takabayashi en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujikiS. en-aut-sei=Fujiki en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KashinoS. en-aut-sei=Kashino en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KambeT. en-aut-sei=Kambe en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IwasaY. en-aut-sei=Iwasa en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=EmuraS. en-aut-sei=Emura en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Physics, Okayama University affil-num=6 en-affil= kn-affil=Japan Advanced Institute of Science and Technology affil-num=7 en-affil= kn-affil=ISIR, Osaka University END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure and physical properties of Na4C60 under ambient and high pressures en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The structure and physical properties of two-dimensional polymeric Na4C60 (body-centered monoclinic, space group I2/m) are studied in a wide temperature region from 12 to 300 K at 1 bar, and in a pressure region up to 53 kbar at 300 K. The temperature dependence of lattice constants suggests a structural anomaly below 100 K where the variation of spin susceptibility is observed from electron spin resonance. The thermal expansion of the unit-cell volume V is smaller than that of monomeric Rb3C60 and K3C60. The compressibility of c is larger than that of a and b, which can be well explained by the repulsion between Na ions. The compressibility of the center-to-center distance in the (10(1) over bar) plane is similar to1/3 times smaller that that in the (101) plane, which can be well explained by the formation of the polymer chains. Further, a possibility of a three-dimensional polymerization is discussed on the basis of the pressure dependence of C-60. . .C-60 distances.

en-copyright= kn-copyright= en-aut-name=KubozonoY. en-aut-sei=Kubozono en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakabayashiY. en-aut-sei=Takabayashi en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KambeT. en-aut-sei=Kambe en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujikiS. en-aut-sei=Fujiki en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KashinoS. en-aut-sei=Kashino en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EmuraS. en-aut-sei=Emura en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=3 en-affil= kn-affil=Department of Physics, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=6 en-affil= kn-affil=ISIR, Osaka University END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=6 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20058 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Carbon-substitution dependent multiple superconducting gap of MgB2: A sub-meV resolution photoemission study en-subtitle= kn-subtitle= en-abstract= kn-abstract=

"Sub-meV" resolution photoemission spectroscopy was used to study carbon-substitution dependence of the multiple superconducting gap of Mg(B1-xCx)(2). Two features corresponding to sigma and pi gaps are clearly observed in the raw spectra up to carbon concentration x=0.075. The observed x dependence of the two gaps shows a qualitatively different behavior: the sigma gap is proportional to T-c while the pi gap shows negligible change. Doping as well as temperature dependence can be explained within the two-band mean-field theory. Implications from the present study are discussed.

en-copyright= kn-copyright= en-aut-name=TsudaS en-aut-sei=Tsuda en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YokoyaT en-aut-sei=Yokoya en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KissT en-aut-sei=Kiss en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimojimaT en-aut-sei=Shimojima en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShinS en-aut-sei=Shin en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TogashiT en-aut-sei=Togashi en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WatanabeS en-aut-sei=Watanabe en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ZhangC en-aut-sei=Zhang en-aut-mei=C kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ChenC T en-aut-sei=Chen en-aut-mei=C T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=LeeS en-aut-sei=Lee en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UchiyamaH en-aut-sei=Uchiyama en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TajimaS en-aut-sei=Tajima en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NakaiN en-aut-sei=Nakai en-aut-mei=N kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=University of Tokyo affil-num=2 en-affil= kn-affil=University of Tokyo affil-num=3 en-affil= kn-affil=Institute of Physical and Chemical Research affil-num=4 en-affil= kn-affil=University of Tokyo affil-num=5 en-affil= kn-affil=University of Tokyo affil-num=6 en-affil= kn-affil=Institute of Physical and Chemical Research affil-num=7 en-affil= kn-affil=University of Tokyo affil-num=8 en-affil= kn-affil=Beijing Center for Crystal R&D affil-num=9 en-affil= kn-affil=Beijing Center for Crystal R&D affil-num=10 en-affil= kn-affil=International Superconductivity Technology Center affil-num=11 en-affil= kn-affil=International Superconductivity Technology Center affil-num=12 en-affil= kn-affil=International Superconductivity Technology Center affil-num=13 en-affil= kn-affil=Kyoto University affil-num=14 en-affil= kn-affil=Okayama University en-keyword=magnesium diboride kn-keyword=magnesium diboride en-keyword=single-crystals kn-keyword=single-crystals en-keyword=origin kn-keyword=origin en-keyword=boron kn-keyword=boron END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=23 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure and physical properties of Cs3+alpha C60 (alpha=0.0-1.0) under ambient and high pressures en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The intermediate phases Cs3+alphaC60 (alpha=0.0-1.0), have been prepared, and their structure and physical properties are studied by x-ray powder diffraction, Raman, ESR, electric conductivity, and ac susceptibility measurements under ambient and high pressures. The x-ray powder diffraction pattern of Cs3+alphaC60 (alpha=0.0-1.0) can be indexed as a mixture of the body-centered-orthorhombic (bco) and cubic (A15) phases. The A15 phase diminishes above 30 kbar. The broad ESR peak due to the conduction electron (c-ESR) is observed only for the phases around alpha=0.0 in Cs3+alphaC60. The resistivity of the Cs3+alphaC60 (alphanot equal0) sample follows the granular metal theory and/or Sheng model even in the sample exhibiting a broad ESR peak. No superconducting transition is observed up to 10.6 kbar in Cs3+alphaC60 (alphanot equal0). These results present that bco phase of Cs3+alphaC60 (alpha=0) is a final candidate for a pressure-induced superconductor.

en-copyright= kn-copyright= en-aut-name=FujikiS. en-aut-sei=Fujiki en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KubozonoY. en-aut-sei=Kubozono en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KobayashiM. en-aut-sei=Kobayashi en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KambeT. en-aut-sei=Kambe en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=RikiishiY. en-aut-sei=Rikiishi en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KashinoS. en-aut-sei=Kashino en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshiiK. en-aut-sei=Ishii en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuematsuH. en-aut-sei=Suematsu en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraA. en-aut-sei=Fujiwara en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Vacuum UV Photoscience, Institute for Molecular Science affil-num=3 en-affil= kn-affil=Department of Materials Science, Himeji Institute of Technology affil-num=4 en-affil= kn-affil=Department of Physics, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=6 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=7 en-affil= kn-affil=Department of Physics, The University of Tokyo affil-num=8 en-affil= kn-affil=Department of Physics, The University of Tokyo affil-num=9 en-affil= kn-affil=Japan Advanced Institute of Science and Technology END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=10 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phase diagram of water between hydrophobic surfaces en-subtitle= kn-subtitle= en-abstract= kn-abstract=Molecular dynamics simulations demonstrate that there are at least two classes of quasi-two-dimensional solid water into which liquid water confined between hydrophobic surfaces freezes spontaneously and whose hydrogen-bond networks are as fully connected as those of bulk ice. One of them is the monolayer ice and the other is the bilayer solid which takes either a crystalline or an amorphous form. Here we present the phase transformations among liquid, bilayer amorphous (or crystalline) ice, and monolayer ice phases at various thermodynamic conditions, then determine curves of melting, freezing, and solid-solid structural change on the isostress planes where temperature and intersurface distance are variable, and finally we propose a phase diagram of the confined water in the temperature-pressure-distance space. en-copyright= kn-copyright= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Okayama University en-keyword=MOLECULAR-DYNAMICS SIMULATION kn-keyword=MOLECULAR-DYNAMICS SIMULATION en-keyword=CONFINED WATER kn-keyword=CONFINED WATER en-keyword=LIQUID WATER kn-keyword=LIQUID WATER en-keyword=SOLVATION FORCES; CARBON NANOTUBES kn-keyword=SOLVATION FORCES; CARBON NANOTUBES en-keyword=BILAYER ICE kn-keyword=BILAYER ICE en-keyword=EQUILIBRIA kn-keyword=EQUILIBRIA en-keyword=TRANSITION kn-keyword=TRANSITION en-keyword=WALLS kn-keyword=WALLS en-keyword=INTERFACE kn-keyword=INTERFACE END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=8 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070828 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phase equilibria and interfacial tension of fluids confined in narrow pores en-subtitle= kn-subtitle= en-abstract= kn-abstract=Correlation between phase behaviors of a Lennard-Jones fluid in and outside a pore is examined over wide thermodynamic conditions by grand canonical Monte Carlo simulations. A pressure tensor component of the confined fluid, a variable controllable in simulation but usually uncontrollable in experiment, is related with the pressure of a bulk homogeneous system in equilibrium with the confined system. Effects of the pore dimensionality, size, and attractive potential on the correlations between thermodynamic properties of the confined and bulk systems are clarified. A fluid-wall interfacial tension defined as an excess grand potential is evaluated as a function of the pore size. It is found that the tension decreases linearly with the inverse of the pore diameter or width. en-copyright= kn-copyright= en-aut-name=HamadaYoshinobu en-aut-sei=Hamada en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=MONTE-CARLO-SIMULATION kn-keyword=MONTE-CARLO-SIMULATION en-keyword=CARBON NANOTUBES kn-keyword=CARBON NANOTUBES en-keyword=WATER kn-keyword=WATER en-keyword=TRANSITION kn-keyword=TRANSITION en-keyword=NANOSPACES kn-keyword=NANOSPACES en-keyword=ADSORPTION kn-keyword=ADSORPTION en-keyword=NANOPORES kn-keyword=NANOPORES en-keyword=SURFACE kn-keyword=SURFACE en-keyword=LIQUID kn-keyword=LIQUID en-keyword=WALLS kn-keyword=WALLS END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20037 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Scanning tunneling microscopy of Dy@C82 and Dy@C60 adsorbed on Si(111)-(7x7) surfaces en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Dy@C-82 and Dy@C-60 adsorbed on Si(111)-(7x7) surface are investigated by scanning tunneling microscopy (STM) at 295 K. The Dy@C-82 molecules in the first layer are adsorbed on the Si(111)-(7x7) surface without formation of islands and nucleation, and the internal structure of the Dy@C-82 molecule is first observed on the surface at 295 K. The average heights of the Dy@C-82 molecules in the first and second layers are estimated to be 7.2 and 10.8 A, respectively, by STM. These results suggest strong interactions between the Si atoms and the Dy@C-82 molecules in the first layer. The STM image reveals that the Dy@C-60 molecule is nearly spherical, showing that the metal endohedral C-60 possesses a cage-form structure.

en-copyright= kn-copyright= en-aut-name=FujikiSatoshi en-aut-sei=Fujiki en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HosokawaTomoko en-aut-sei=Hosokawa en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanbaraTakayoshi en-aut-sei=Kanbara en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraAkihiko en-aut-sei=Fujiwara en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NonogakiYouichi en-aut-sei=Nonogaki en-aut-mei=Youichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UrisuTsuneo en-aut-sei=Urisu en-aut-mei=Tsuneo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Graduate University for Advanced Studies affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Tohoku University affil-num=5 en-affil= kn-affil=Japan Advanced Institute of Science and Technology affil-num=6 en-affil= kn-affil=Institute for Molecular Science affil-num=7 en-affil= kn-affil=Graduate University for Advanced Studies en-keyword=endohedral metallofullerenes kn-keyword=endohedral metallofullerenes en-keyword=electronic-properties kn-keyword=electronic-properties en-keyword=c-60 kn-keyword=c-60 END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=17 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antiferromagnetic ordering driven by the molecular orbital order of C-60 in alpha '-tetra-kis-(dimethylamino)-ethylene-C-60 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have studied the ground state of a fullerene-based magnet, the alpha'-phase tetra-kis-(dimethylamino)ethylene-C-60 (alpha'-TDAE-C-60), by electron spin resonance and magnetic torque measurements. Below T-N = 7 K, nonparamagnetic field dependent resonances with a finite excitation gap ( 1.7 GHz) are observed along the a axis. Strong enhancement in their intensity as temperature is decreased is inconsistent with excitation from a singlet state, which had been proposed for the alpha'-phase ground state. Below T-N, nonquadratic field dependence of the magnetic torque signal is also observed in contrast to quadratic field dependence in the paramagnetic phase. The angle-dependent torque signals below T-N indicate the existence of an anisotropy of the bulk magnetization. From both experiments, we propose an antiferro-magnetic ground state driven by the cooperative orientational ordering of C-60 in the alpha'-TDAE-C-60.

en-copyright= kn-copyright= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KajiyoshiKoichi en-aut-sei=Kajiyoshi en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraMotoyasu en-aut-sei=Fujiwara en-aut-mei=Motoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OshimaKokichi en-aut-sei=Oshima en-aut-mei=Kokichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=TDAE-C-60 kn-keyword=TDAE-C-60 en-keyword=Ferromagnetism kn-keyword=Ferromagnetism en-keyword=(NH3)K3C60 kn-keyword=(NH3)K3C60 en-keyword=ESR kn-keyword=ESR END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=22 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20056 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Superconductivity of the ternary boride Li2Pd3B probed by B-11 NMR en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We report a B-11 NMR measurement on the recently discovered superconductor Li2Pd3B. The nuclear spin lattice relaxation rate 1/T-1 shows a well-defined coherence peak just below T-c(H=1.46 T)=5.7 K, and the spin susceptibility measured by the Knight shift also decreases below T-c. These results indicate that the superconductivity is of conventional nature, with an isotropic gap. Our results also suggest that the p-electrons of boron and the d-electrons of palladium that hybridize with boron p-electrons are primarily responsible for the superconductivity.

en-copyright= kn-copyright= en-aut-name=NishiyamaM en-aut-sei=Nishiyama en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InadaY en-aut-sei=Inada en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZhengGuo-qing en-aut-sei=Zheng en-aut-mei=Guo-qing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=5 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20062 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Field-induced ferromagnetic order and colossal magnetoresistance in la1.2Sr1.8mn2O7:a La139 nmr study en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In order to gain insights into the origin of colossal magnetoresistance (CMR) in manganese oxides, we performed a La-139 NMR study in the double-layered compound La1.2Sr1.8Mn2O7. We find that above the Curie temperature T-C = 126 K, applying a magnetic field induces a long-range ferromagnetic order that persists up to T = 330 K. The critical field at which the induced magnetic moment is saturated coincides with the field at which the CMR effect reaches a maximum. Our results therefore indicate that the CMR observed above T-C in this compound is due to the field-induced ferromagnetism that produces a metallic state via the double exchange interaction.

en-copyright= kn-copyright= en-aut-name=ShiotaniY en-aut-sei=Shiotani en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SarraoJ L en-aut-sei=Sarrao en-aut-mei=J L kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZhengGuo-qing en-aut-sei=Zheng en-aut-mei=Guo-qing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Osaka University affil-num=2 en-affil= kn-affil=Los Alamos National Laboratory affil-num=3 en-affil= kn-affil=Okayama University en-keyword=equal-to 0.50 kn-keyword=equal-to 0.50 en-keyword=giant magnetoresistance kn-keyword=giant magnetoresistance en-keyword=resistivity kn-keyword=resistivity en-keyword=manganites kn-keyword=manganites en-keyword=phase kn-keyword=phase en-keyword=crystal kn-keyword=crystal en-keyword=oxides kn-keyword=oxides END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=7 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20052 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Two-photon spectroscopy of core excitons in barium fluoride using synchrotron radiation and laser light en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have conducted two-photon spectroscopy of core excitons in BaF2. Synchrotron radiation and laser light were used for 5p core-electron excitation and Auger-free luminescence was detected as the signal. Two-photon excitation enables access to f and p orbitals that cannot be reached by one-photon excitation of electrons in p orbitals. It has been found that the spin-orbit splittings of 4f and 6p states of the Ba ion in BaF2 are 0.7 +/- 0.1 and 1.4 +/- 0.1 eV, respectively.

en-copyright= kn-copyright= en-aut-name=TsujibayashiToru en-aut-sei=Tsujibayashi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ItohMinoru en-aut-sei=Itoh en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AzumaJunpei en-aut-sei=Azuma en-aut-mei=Junpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WatanabeMasayuki en-aut-sei=Watanabe en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ArimotoOsamu en-aut-sei=Arimoto en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakanishiShunsuke en-aut-sei=Nakanishi en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Osaka Dental University affil-num=2 en-affil= kn-affil=Shinshu University affil-num=3 en-affil= kn-affil=Synchrotron Light Application Center affil-num=4 en-affil= kn-affil=Kyoto University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Kagawa University en-keyword=electronicstructure kn-keyword=electronicstructure en-keyword=spectra kn-keyword=spectra en-keyword=absorption kn-keyword=absorption en-keyword=crystals kn-keyword=crystals en-keyword=baf2 kn-keyword=baf2 en-keyword=sns kn-keyword=sns en-keyword=ges kn-keyword=ges END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=23 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19972 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Scanning tunneling microscopy/spectroscopy studies of two isomers of Ce@C82 on Si(111)-(7~7）surfaces en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Scanning tunneling microscopy images for two isomers of Ce@C-82 were observed on Si(111)-(7x7) at 295 K. The Ce@C-82 molecules in the first layer were bound to the Si surfaces, and the motions were frozen even at 295 K. The multilayer of the Ce@C-82 isomer I (Ce@C-82-I) produced a close-packed structure in the surface layer by annealing the Si substrate at 473 K. The distance between the nearest-neighboring molecules was 1.15(4) nm whose value was consistent with that, 1.12 nm, estimated from x-ray diffraction of the Ce@C-82-I crystals. This implies that the close-packed structure is dominated by van der Waals forces, as in crystals of Ce@C-82-I. The internal structure of Ce@C-82-I was observed in the first layer due to a freeze of molecular motion caused by strong interactions between the molecule and the Si adatoms in the surface. Scanning tunneling spectroscopy revealed that the energy gaps for Ce@C-82-I and -II in the first layer opened to gap energies, E-g of 0.7 and 1.0 eV, respectively. This fact suggests that these molecules are semiconductors with smaller value of E-g than those for C-60 and C-70.

en-copyright= kn-copyright= en-aut-name=FujikiSatoshi en-aut-sei=Fujiki en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RikiishiYoshie en-aut-sei=Rikiishi en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UrisuTsuneo en-aut-sei=Urisu en-aut-mei=Tsuneo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate University for Advanced Studies affil-num=2 en-affil= kn-affil=Science and Technology Agency affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Graduate University for Advanced Studies en-keyword=electronic-structure kn-keyword=electronic-structure en-keyword=endohedral metallofullerenes kn-keyword=endohedral metallofullerenes en-keyword=microscopy kn-keyword=microscopy en-keyword=lanthanum kn-keyword=lanthanum en-keyword=crystal kn-keyword=crystal en-keyword=anion kn-keyword=anion en-keyword=films kn-keyword=films END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=15 article-no= start-page=7304 end-page=7312 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041015 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hydrophobic effect in the pressure-temperature plane en-subtitle= kn-subtitle= en-abstract= kn-abstract=The free energy of the hydrophobic hydration and the strength of the solvent-mediated attraction between hydrophobic solute molecules are calculated in the pressure-temperature plane. This is done in the framework of an exactly soluble model that is an extension of the lattice model proposed by Kolomeisky and Widom [A. B. Kolomeisky and B. Widom, Faraday Discuss. 112, 81 (1999)]. The model takes into account both the mechanism of the hydrophobic effect dominant at low temperatures and the opposite mechanism of solvation appearing at high temperatures and has the pressure as a second thermodynamic variable. With this model, two boundaries are identified in the pressure-temperature plane: the first one within which the solubility, or the Ostwald absorption coefficient, decreases with increasing temperature at fixed pressure and the second one within which the strength of solvent-mediated attraction increases with increasing temperature. The two are nearly linear and parallel to each other, and the second boundary lies in the low-temperature and low-pressure side of the first boundary. It is found that a single, near-linear relation between the hydration free energy and the strength of the hydrophobic attraction holds over the entire area within the second boundary in the pressure-temperature plane. (C) 2004 American Institute of Physics. en-copyright= kn-copyright= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=FREE-ENERGY kn-keyword=FREE-ENERGY en-keyword=AQUEOUS ARGON kn-keyword=AQUEOUS ARGON en-keyword=DEPENDENCE kn-keyword=DEPENDENCE en-keyword=WATER kn-keyword=WATER en-keyword=HYDRATION kn-keyword=HYDRATION en-keyword=ENTROPY kn-keyword=ENTROPY en-keyword=MODEL kn-keyword=MODEL en-keyword=DENATURATION kn-keyword=DENATURATION en-keyword=SIMULATIONS kn-keyword=SIMULATIONS en-keyword=ATTRACTION kn-keyword=ATTRACTION END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=14 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20064 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tomonaga-luttinger liquid in a quasi-one-dimensional s=1 antiferromagnet observed by specific heat measurements en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Specific-heat experiments on single crystals of the S=1 quasi-one-dimensional bond-alternating antiferromagnet Ni(C9H24N4)(NO2)ClO4 (NTENP) have been performed in magnetic fields applied both parallel and perpendicular to the spin chains. We have found for the parallel field configuration that the magnetic specific heat (C-mag) is proportional to temperature (T) above a critical field H-c, at which the energy gap vanishes, in a temperature region above that of the long-range ordered state. The ratio C-mag/T increases as the magnetic field approaches H-c from above. The data are in good quantitative agreement with the prediction of the c=1 conformal field theory in conjunction with the velocity of the excitations calculated by a numerical diagonalization, providing conclusive evidence for a Tomonaga-Luttinger liquid.

en-copyright= kn-copyright= en-aut-name=HagiwaraM en-aut-sei=Hagiwara en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsujiiH en-aut-sei=Tsujii en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RotunduC R en-aut-sei=Rotundu en-aut-mei=C R kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AndrakaB en-aut-sei=Andraka en-aut-mei=B kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakanoY en-aut-sei=Takano en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TateiwaN en-aut-sei=Tateiwa en-aut-mei=N kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiT C en-aut-sei=Kobayashi en-aut-mei=T C kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuzukiT en-aut-sei=Suzuki en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SugaS en-aut-sei=Suga en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Osaka University affil-num=2 en-affil= kn-affil=The Institute of Physical and Chemical Research affil-num=3 en-affil= kn-affil=University of Florida affil-num=4 en-affil= kn-affil=University of Florida affil-num=5 en-affil= kn-affil=University of Florida affil-num=6 en-affil= kn-affil=Japan Atomic Energy Agency affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Osaka University affil-num=9 en-affil= kn-affil=Osaka University en-keyword=magnetic-field kn-keyword=magnetic-field en-keyword=alternating chain kn-keyword=alternating chain en-keyword=heisenberg chain kn-keyword=heisenberg chain en-keyword=phasetransition kn-keyword=phasetransition en-keyword=cu-2 (c5h12n2)(2)cl-4 kn-keyword=cu-2 (c5h12n2)(2)cl-4 en-keyword=ladders kn-keyword=ladders en-keyword=condensation kn-keyword=condensation en-keyword=charge kn-keyword=charge en-keyword=f5pnn kn-keyword=f5pnn END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=12 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20069 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Generic phase diagram of fermion superfluids with population imbalance en-subtitle= kn-subtitle= en-abstract= kn-abstract=

It is shown by microscopic calculations for trapped imbalanced Fermi superfluids that the gap function always has sign changes, i.e., the Fulde-Ferrell-Larkin-Ovchinnikov (FFLO)-like state, up to a critical imbalance P-c, beyond which normal state becomes stable, at temperature T=0. A temperature-versus-pressure phase diagram is constructed, where the BCS state without sign change is stable only at T not equal 0. We reproduce the observed bimodality in the density profile to identify its origin and evaluate P-c as functions of T and the coupling strength. These dependencies match with the recent experiments.

en-copyright= kn-copyright= en-aut-name=MachidaK en-aut-sei=Machida en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizushimaT en-aut-sei=Mizushima en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchiokaM en-aut-sei=Ichioka en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=molecular-field kn-keyword=molecular-field en-keyword=superconductivity kn-keyword=superconductivity en-keyword=gas kn-keyword=gas END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070728 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On the thermodynamic stability of hydrogen clathrate hydrates en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cage occupancy of hydrogen clathrate hydrate has been examined by grand canonical Monte Carlo (GCMC) simulations for wide ranges of temperature and pressure. The simulations are carried out with a fixed number of water molecules and a fixed chemical potential of the guest species so that hydrogen molecules can be created or annihilated in the clathrate. Two types of the GCMC simulations are performed; in one the volume of the clathrate is fixed and in the other it is allowed to adjust itself under a preset pressure so as to take account of compression by a hydrostatic pressure and expansion due to multiple cage occupancy. It is found that the smaller cage in structure II is practically incapable of accommodating more than a single guest molecule even at pressures as high as 500 MPa, which agrees with the recent experimental investigations. The larger cage is found to encapsulate at most 4 hydrogen molecules, but its occupancy is dependent significantly on the pressure of hydrogen. en-copyright= kn-copyright= en-aut-name=KatsumasaKeisuke en-aut-sei=Katsumasa en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=OCCUPANCY kn-keyword=OCCUPANCY en-keyword=CLUSTERS kn-keyword=CLUSTERS en-keyword=STORAGE kn-keyword=STORAGE en-keyword=CAGES kn-keyword=CAGES en-keyword=WATER kn-keyword=WATER END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=7 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On the thermodynamic stability and structural transition of clathrate hydrates en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gas mixtures of methane and ethane form structure II clathrate hydrates despite the fact that each of pure methane and pure ethane gases forms the structure I hydrate. Optimization of the interaction potential parameters for methane and ethane is attempted so as to reproduce the dissociation pressures of each simple hydrate containing either methane or ethane alone. An account for the structural transitions between type I and type II hydrates upon changing the mole fraction of the gas mixture is given on the basis of the van der Waals and Platteeuw theory with these optimized potentials. Cage occupancies of the two kinds of hydrates are also calculated as functions of the mole fraction at the dissociation pressure and at a fixed pressure well above the dissociation pressure. en-copyright= kn-copyright= en-aut-name=KoyamaYuji en-aut-sei=Koyama en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=STRUCTURE-II kn-keyword=STRUCTURE-II en-keyword=POTENTIAL FUNCTIONS kn-keyword=POTENTIAL FUNCTIONS en-keyword=ETHANE kn-keyword=ETHANE en-keyword=METHANE kn-keyword=METHANE en-keyword=GAS kn-keyword=GAS en-keyword=MOLECULES kn-keyword=MOLECULES en-keyword=MIXTURES kn-keyword=MIXTURES en-keyword=PROPANE kn-keyword=PROPANE en-keyword=WATER kn-keyword=WATER END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=10 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20063 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Observation of a half step magnetization in the {Cu-3}-type triangular spin ring en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We report pulsed field magnetization and ESR experiments on a {Cu-3} nanomagnet, where antiferromagnetically coupled Cu2+ (S=1/2) ions form a slightly distorted triangle. The remarkable feature is the observation of a half step magnetization, hysteresis loops, and an asymmetric magnetization between a positive and a negative field in a fast sweeping external field. This is attributed to an adiabatic change of magnetization. The energy levels determined by ESR unveil that the different mixing nature of a spin chirality of a total S=1/2 Kramers doublet by virtue of Dzyaloshinskii-Moriya interactions is decisive for inducing half step magnetization.

en-copyright= kn-copyright= en-aut-name=ChoiKwang-Yong en-aut-sei=Choi en-aut-mei=Kwang-Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsudaYasuhiro H en-aut-sei=Matsuda en-aut-mei=Yasuhiro H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NojiriHiroyuki en-aut-sei=Nojiri en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Tohoku University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Tohoku University en-keyword=molecular magnets kn-keyword=molecular magnets en-keyword=quantum dynamics kn-keyword=quantum dynamics END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=14 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polymer phase of the tetrakis(dimethylamino)ethylene-C-60 organic ferromagnet en-subtitle= kn-subtitle= en-abstract= kn-abstract=

High-pressure electron spin resonance (ESR) measurements were performed on tetrakis(dimethylamino) ethylene (TDAE)-C-60 single crystals and stability of the polymeric phase was established in the P-T parameter space. At 7 kbar the system undergoes a ferromagnetic to paramagnetic phase transition due to the pressure-induced polymerization. The polymeric phase remains stable after the pressure release. The depolymerization of the pressure-induced phase was observed at a temperature of 520 K, revealing an unexpectedly high thermal stability of the polymer. Below room temperature, the polymeric phase behaves as a simple Curie-type insulator with one unpaired electron spin per chemical formula. The TDAE(+) donor-related unpaired electron spins, formerly ESR silent, become active above a temperature of 320 K, which demonstrates that the magnetic properties are profoundly defined by miniscule reorientation of TDAE molecules.

en-copyright= kn-copyright= en-aut-name=GarajSlaven en-aut-sei=Garaj en-aut-mei=Slaven kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Forr?L?szl? en-aut-sei=Forr? en-aut-mei=L?szl? kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SienkiewiczAndrzej en-aut-sei=Sienkiewicz en-aut-mei=Andrzej kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraMotoyasu en-aut-sei=Fujiwara en-aut-mei=Motoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OshimaKokichi en-aut-sei=Oshima en-aut-mei=Kokichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Institute of Physics of Complex Matter, ?cole Polytechnique F?d?rale de Lausanne affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Institute of Physics of Complex Matter, ?cole Polytechnique F?d?rale de Lausanne affil-num=4 en-affil= kn-affil=Institute of Physics, Polish Academy of Sciences affil-num=5 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=11 article-no= start-page=5488 end-page=5493 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040915 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On the thermodynamic stability of clathrate hydrates IV: Double occupancy of cages en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have extended the van der Waals and Platteeuw theory to treat multiple occupancy of a single cage of clathrate hydrates, which has not been taken into account in the original theory but has been experimentally confirmed as a real entity. We propose a simple way to calculate the free energy of multiple cage occupancy and apply it to argon clathrate structure II in which a larger cage can be occupied by two argon atoms. The chemical potential of argon is calculated treating it as an imperfect gas, which is crucial to predict accurate pressure dependence of double occupancy expected at high pressure. It is found that double occupancy dominates over single occupancy when the guest pressure in equilibrium with the clathrate hydrate exceeds 270 MPa. (C) 2004 American Institute of Physics. en-copyright= kn-copyright= en-aut-name=TanakaHideki en-aut-sei=Tanaka en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakatsukaTakeharu en-aut-sei=Nakatsuka en-aut-mei=Takeharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=RAMAN-SCATTERING kn-keyword=RAMAN-SCATTERING en-keyword=HIGH-PRESSURES kn-keyword=HIGH-PRESSURES en-keyword=LIQUID WATER kn-keyword=LIQUID WATER en-keyword=AR HYDRATE kn-keyword=AR HYDRATE en-keyword=MOLECULES kn-keyword=MOLECULES END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=125 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Beh?etfs disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD. To investigate the pathogenesis of this isolate, we examined neutrophil 5 reactions and level of cytokine production by lymphocytes after stimulation with the strain. The reactions of neutrophils were examined by chemiluminescence assay using whole blood. The amounts of interferon gamma (IFN-g) and interleukin (IL)-4, IL-8, IL-10, and IL-12 produced by peripheral blood mononuclear cells (PBMCs) were measured by ELISA. 10 Strain BD113-20 activated neutrophils from patients with ABD and healthy volunteers, and, in addition it increased IFN-g production by lymphocytes. Lymphocyte from the patients with ABD showed a dominant T helper 1 (Th-1) immune response. Results indicated that both bacterial stimulation and host hypersensitivity might be involved in the symptoms and pathogenesis of ABD. en-copyright= kn-copyright= en-aut-name=KurauchiTomomi en-aut-sei=Kurauchi en-aut-mei=Tomomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YokotaKenji en-aut-sei=Yokota en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujinamiYoshihito en-aut-sei=Fujinami en-aut-mei=Yoshihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IsogaiEmiko en-aut-sei=Isogai en-aut-mei=Emiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IsogaiHiroshi en-aut-sei=Isogai en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtsukiHiroshi en-aut-sei=Ohtsuki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OgumaKeiji en-aut-sei=Oguma en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry affil-num=2 en-affil= kn-affil=Department of Bacteriology, Okayama University Graduate School of Medicine and Dentistry affil-num=3 en-affil= kn-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry affil-num=4 en-affil= kn-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry affil-num=5 en-affil= kn-affil=Department of Preventive Dentistry, Health Sciences University of Hokkaido affil-num=6 en-affil= kn-affil=Division of Animal Experimentation, Sapporo Medical University affil-num=7 en-affil= kn-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry affil-num=8 en-affil= kn-affil=Department of Bacteriology, Okayama University Graduate School of Medicine and Dentistry en-keyword=Adamantiades-Behcet's disease kn-keyword=Adamantiades-Behcet's disease en-keyword=Streptococcus sanguinis kn-keyword=Streptococcus sanguinis en-keyword=neutrophil kn-keyword=neutrophil en-keyword=chemiluminescence kn-keyword=chemiluminescence en-keyword=IL-8 kn-keyword=IL-8 en-keyword=T helper-1 kn-keyword=T helper-1 en-keyword=IFN-gamma kn-keyword=IFN-gamma en-keyword=IL-12 kn-keyword=IL-12 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Modelling the dynamics and control of Schistosoma japonicum transmission on Bohol island, the Philippines en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have investigated a mathematical model for the transmission of Schistosoma japonicum in the infested region of northeastern Bohol island in the Philippines. The development of transmission models is important for planning control strategies. Since S. japonicum has a complicated mode of transmission, the rates of transmission among its hosts cannot be measured directly by field observation. Instead, they have been estimated through model analysis. The model takes into account the seasonal variations and includes a function of control measures. In 1981, a project to eliminate schistosomiasis started on Bohol island. The prevalence decreased dramatically and has kept low level less than 1%. The simulations based on the model predicted that there is little probability of resurgence of an epidemic in the northeastem endemic villages of Bohol island due to the fact that the project has attained a high coverage of selective mass treatment based oil stool examination accompanied by a successful snail control operation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

en-copyright= kn-copyright= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhmaeHiroshi en-aut-sei=Ohmae en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=PangilinanRogelio en-aut-sei=Pangilinan en-aut-mei=Rogelio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RedullaApolinario en-aut-sei=Redulla en-aut-mei=Apolinario kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsudaHajime en-aut-sei=Matsuda en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=National Institute of Infectious Diseases affil-num=3 en-affil= kn-affil=Schistosomiasis Control Team affil-num=4 en-affil= kn-affil=Schistosomiasis Control Team affil-num=5 en-affil= kn-affil=Dokkyo University School of Medicine en-keyword=schistosomiasis japonica kn-keyword=schistosomiasis japonica en-keyword=control kn-keyword=control en-keyword=mathematical model kn-keyword=mathematical model en-keyword=Philippines kn-keyword=Philippines en-keyword=Bohol kn-keyword=Bohol END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The evaluation of control measures against Schistosoma mekongi in Cambodia by a mathematical model en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We constructed a mathematical model for the transmission of Schistosoma mekongi in Cambodia. The simulation of the model will be instrumental in planning schistosomiasis control measures. The model includes two definitive hosts, humans and dogs, as animal reservoirs. Dogs are recognized to play an important role in schistosomiasis transmission in Cambodia. For the purpose of dealing with age-specific prevalence and intensity of infection, the human population was classified into eight age categories in the model. To describe the seasonal fluctuation of the intermediate host population of S. mekongi, the "Post-Spate Survival" hypothesis was adopted for the population dynamics of Neotricula aperta present in the Mekong River. We carried out simulations to evaluate the effect of universal treatment (UT) and targeted mass treatment (TT) with praziquantel on the reduction in prevalence of S. mekongi. The simulations indicated that biyearly UT for 8 years or yearly TT for 5 years after three courses of yearly UT could reduce the prevalence to below 5% when a UT or TT coverage of 85% of inhabitants was achieved. The simulation suggested that the suppression of S. mekongi in Cambodia would be possible by UT or TT with a high coverage rate.

en-copyright= kn-copyright= en-aut-name=HisakaneNaoto en-aut-sei=Hisakane en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KirinokiMasashi en-aut-sei=Kirinoki en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChigusaYuichi en-aut-sei=Chigusa en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SinuonMuth en-aut-sei=Sinuon en-aut-mei=Muth kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SocheatDuong en-aut-sei=Socheat en-aut-mei=Duong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsudaHajime en-aut-sei=Matsuda en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University affil-num=2 en-affil= kn-affil=Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine affil-num=3 en-affil= kn-affil=Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine affil-num=4 en-affil= kn-affil=National Center for Parasitology, Entomology and Malaria Control, Ministry of Health affil-num=5 en-affil= kn-affil=National Center for Parasitology, Entomology and Malaria Control, Ministry of Health affil-num=6 en-affil= kn-affil=Institute of International Education and Research, Dokkyo Medical University School of Medicine affil-num=7 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University, en-keyword=Schistosoma mekongi kn-keyword=Schistosoma mekongi en-keyword=Cambodia kn-keyword=Cambodia en-keyword=mathematical model kn-keyword=mathematical model en-keyword=Neotricula aperta kn-keyword=Neotricula aperta en-keyword=Mekong River kn-keyword=Mekong River END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=3 article-no= start-page=117 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20043 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Vibrio vulnificus biotype 1, a causative agent of fatal septicemia or wound infection in humans, is known to produce a toxic metalloprotease as an important virulence determinant. V. vulnificus biotype 2 (serovar E), a primary eel pathogen, was found to elaborate an extracellular metalloprotease that was indistinguishable from that of biotype 1. The potential of V. vulnificus biotype 1 for production of the metalloprotease was compared with biotype 2 and other human non-pathogenic Vibrio species (Vibrio anguillarum and Vibrio proteolyticus). When cultivated at 25degreesC in tryptone-yeast extract broth supplemented with 0.9% NaCl, all bacteria multiplied sufficiently and secreted significant amounts of the metalloprotease. However, at 37degreesC with 0.9% NaCl, V. anguillarum neither grew nor produced the metalloprotease. In human serum, only V. vulnificus biotype 1 revealed a steady multiplication accompanied with production of the extracellular metalloprotease. This prominent ability of biotype 1 in growth and protease production may contribute to cause serious systemic diseases in humans.

en-copyright= kn-copyright= en-aut-name=WatanabeHirofumi en-aut-sei=Watanabe en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawaseTomoka en-aut-sei=Kawase en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomochikaKen-ichi en-aut-sei=Tomochika en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShinodaSumio en-aut-sei=Shinoda en-aut-mei=Sumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama Univeristy affil-num=5 en-affil= kn-affil=Okayama University en-keyword=vibrio vulnificus kn-keyword=vibrio vulnificus en-keyword=metalloprotease kn-keyword=metalloprotease en-keyword=protease kn-keyword=protease END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=6 article-no= start-page=444 end-page=451 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030729 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A model for the transmission of Echinococcus multilocularis in Hokkaido, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A mathematical model for Echinococcus multilocularis transmission would be useful to estimate its prevalence and manage control strategies. We propose a mathematical model which quantitatively describes the transmission of E. multilocularis in Hokkaido, Japan. The model takes into account the influence of the dynamics of both the definitive and the intermediate host populations, which show large scale seasonal variations as they are wild animals. The simulations based on the model clarify the mechanism for the seasonal transmission of E. multilocularis quantitatively, notwithstanding a lack of seasonal prevalence data. At present, human alveolar echinococcosis is prevalent throughout the mainland of Hokkaido. The risk of being infected with alveolar echinococcosis in the human population has been investigated by analyzing the seasonal fluctuation of parasite egg dispersal in the environment, which should be necessary for planning more suitable preventive measures against E. multilocularis.

en-copyright= kn-copyright= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhgaYukio en-aut-sei=Ohga en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DoiRikuo en-aut-sei=Doi en-aut-mei=Rikuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Horiba Limited affil-num=3 en-affil= kn-affil=Yokohama City University en-keyword=computer simulation kn-keyword=computer simulation en-keyword=echinococcus multilocularis kn-keyword=echinococcus multilocularis en-keyword=hokkaido kn-keyword=hokkaido en-keyword=japan kn-keyword=japan en-keyword=transmission model kn-keyword=transmission model END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mathematical modeling of Echinococcus multilocularis transmission en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A mathematical model for the transmission cycle of Echinococcus multilocularis would be useful for estimating its prevalence, and the model simulation can be instrumental in designing various control strategies. This review focuses on the epidemiological factors in the E. multilocularis transmission cycle and the recent advances of mathematical models for E. multilocularis transmission.

en-copyright= kn-copyright= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=Echinococcus multilocularis kn-keyword=Echinococcus multilocularis en-keyword=fox kn-keyword=fox en-keyword=mathematical model kn-keyword=mathematical model en-keyword=vole kn-keyword=vole END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=2 article-no= start-page=152 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elicitin-responsive lectin-like receptor kinase genes in BY-2 cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The inhibition of elicitor-induced plant defense responses by the protein kinase inhibitors K252a and staurosporine indicates that defense responses require protein phosphorylation. We isolated a cDNA clone encoding Nicotiana tabacum lectin-like receptor protein kinase 1 ( NtlecRK1), an elicitor-responsive gene; in tobacco bright yellow ( BY-2) cells by a differential display method. NtlecRK forms a gene family with at least three members in tobacco. All three NtlecRK genes potentially encode the N-terminal legume lectin domain, transmembrane domain and C-terminal Ser/Thr-type protein kinase domain. Green fluorescent protein ( GFP) fusion showed that the NtlecRK1 protein was located on the plasma membrane. In addition, NtlecRK1 and 3 were responsive to INF1 elicitin and the bacterial elicitor harpin. These results indicate that NtlecRKs are membrane-located protein kinases that are induced during defense responses in BY-2 cells.

en-copyright= kn-copyright= en-aut-name=SasabeMichiko en-aut-sei=Sasabe en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaitoKana en-aut-sei=Naito en-aut-mei=Kana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuenagaHiroko en-aut-sei=Suenaga en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaTakako en-aut-sei=Ikeda en-aut-mei=Takako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InagakiYoshishige en-aut-sei=Inagaki en-aut-mei=Yoshishige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University en-keyword=defense response kn-keyword=defense response en-keyword=elicitin kn-keyword=elicitin en-keyword=lectin kn-keyword=lectin en-keyword=receptor-like kinase kn-keyword=receptor-like kinase en-keyword=tobacco BY-2 kn-keyword=tobacco BY-2 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3 article-no= start-page=465 end-page=479 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A stochastic model of Echinococcus multilocularis transmission in Hokkaido, Japan, focusing on the infection process en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Echinococcus multilocularis causes human alveolar echinococcus. In Japan, high prevalence of E. multilocularis among the fox population has been reported throughout Hokkaido. Accordingly, control measures, such as fox hunting and the distribution of bait containing Praziquantel, have been conducted. This study developed a transmission model for individuals in the fox population and included a stochastic infection process to assess the prevalence of E. multilocularis. To make our model realistic, we used the worm burden for each individual in the fox population. We assumed that the worm burden depends on the number of protoscoleces in a predated vole and the number of infection experiences. We carried out stochastic simulations with 1,000 trials for the situations of Koshimizu and Sapporo, Hokkaido, Japan. The distribution of the worm burden among foxes obtained using the model agreed with dissection data. The simulation indicates that a careful choice of season is necessary for an effective distribution of Praziquantel-containing bait. A stochastic model for E. multilocularis, which can assess the range of the prevalence in the fox population, would be helpful in analyzing their complex life-cycle and also in designing control strategies.

en-copyright= kn-copyright= en-aut-name=NishinaTomohiko en-aut-sei=Nishina en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University en-keyword=Echinococcus multilocularis kn-keyword=Echinococcus multilocularis en-keyword=stochastic model kn-keyword=stochastic model en-keyword=control strategy kn-keyword=control strategy en-keyword=Hokkaido kn-keyword=Hokkaido END start-ver=1.4 cd-journal=joma no-vol=188 cd-vols= no-issue=24 article-no= start-page=8376 end-page=8384 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A homologue of the 3-oxoacyl-(acyl carrier protein) synthase III gene located in the glycosylation island of Pseudomonas syringae pv. tabaci regulates virulence factors via N-acyl homoserine lactone and fatty acid synthesis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pseudomonas syringae pv. tabaci 6605 possesses a genetic region involved in flagellin glycosylation. This region is composed of three open reading frames: orf1, orf2, and orf3. Our previous study revealed that orf1 and orf2 encode glycosyltransferases; on the other hand, orf3 has no role in posttranslational modification of flagellin. Although the function of Orf3 remained unclear, an orf3 deletion mutant (Delta orf3 mutant) had reduced virulence on tobacco plants. Orf3 shows significant homology to a 3-oxoacyl-(acyl carrier protein) synthase III in the fatty acid elongation cycle. The Delta orf3 mutant had a significantly reduced ability to form acyl homoserine lactones (AHLs), which are quorum-sensing molecules, suggesting that Orf3 is required for AHL synthesis. In comparison with the wild-type strain, swarming motility, biosurfactant production, and tolerance to H2O2 and antibiotics were enhanced in the Delta orf3 mutant. A scanning electron micrograph of inoculated bacteria on the tobacco leaf surface revealed that there is little extracellular polymeric substance matrix surrounding the cells in the Delta orf3 mutant. The phenotypes of the Delta orf3 mutant and an AHL synthesis (Delta psyI) mutant were similar, although the mutant-specific characteristics were more extreme in the Delta orf3 mutant. The swarming motility of the Delta orf3 mutant was greater than that of the Delta psyI mutant. This was attributed to the synergistic effects of the overproduction of biosurfactants and/or alternative fatty acid metabolism in the Delta orf3 mutant. Furthermore, the amounts of iron and biosurfactant seem to be involved in biofilm development under quorum-sensing regulation in P. syringae pv. tabaci 6605. en-copyright= kn-copyright= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OgawaYujiro en-aut-sei=Ogawa en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakeuchiKasumi en-aut-sei=Takeuchi en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiTomoko en-aut-sei=Suzuki en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University en-keyword=TO-CELL SIGNALS kn-keyword=TO-CELL SIGNALS en-keyword=AERUGINOSA kn-keyword=AERUGINOSA en-keyword=FLAGELLIN kn-keyword=FLAGELLIN en-keyword=BIOFILMS kn-keyword=BIOFILMS en-keyword=MOTILITY kn-keyword=MOTILITY en-keyword=IRON kn-keyword=IRON en-keyword=IDENTIFICATION kn-keyword=IDENTIFICATION en-keyword=SIDEROPHORES kn-keyword=SIDEROPHORES en-keyword=SPECIFICITY kn-keyword=SPECIFICITY en-keyword=FLUORESCENT kn-keyword=FLUORESCENT END start-ver=1.4 cd-journal=joma no-vol=189 cd-vols= no-issue=19 article-no= start-page=6945 end-page=6956 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flagellin Glycans from two pathovars of Pseudomonas syringae contain rhamnose in D and L configurations in different ratios and modified 4-amino-4,6-dideoxyglucose en-subtitle= kn-subtitle= en-abstract= kn-abstract=Flagellins from Pseudomonas syringae pv. glycinea race 4 and Pseudomonas syringae pv. tabaci 6605 have been found to be glycosylated. Glycosylation of flagellin is essential for bacterial virulence and is also involved in the determination of host specificity. Flagellin glycans from both pathovars were characterized, and common sites of glycosylation were identified on six serine residues (positions 143, 164, 176, 183, 193, and 201). The structure of the glycan at serine 201 (S201) of flagellin from each pathovar was determined by sugar composition analysis, mass spectrometry, and H-1 and C-13 nuclear magnetic resonance spectroscopy. These analyses showed that the S201 glycans from both pathovars were composed of a common unique trisaccharide consisting of two rhamnosyl (Rha) residues and one modified 4-amino-4,6-dideoxyglucosyl (Qui4N) residue, beta-D-Quip4N(3-hydroxy-1-oxobutyl)2Me-(1 -> 3)-alpha-L-Rhap-(1 -> 2)-alpha-L-Rhap. Furthermore, mass analysis suggests that the glycans on each of the six serine residues are composed of similar trisaccharide units. Determination of the enantiomeric ratio of Rha from the flagellin proteins showed that flagellin from P. syringae pv. tabaci 6605 consisted solely Of L-Rha, whereas P. syringae pv. glycinea race 4 flagellin contained both L-Rha and D-Rha at a molar ratio of about 4:1. Taking these findings together with those from our previous study, we conclude that these flagellin glycan structures may be important for the virulence and host specificity of P. syringae. en-copyright= kn-copyright= en-aut-name=TakeuchiKasumi en-aut-sei=Takeuchi en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OnoHiroshi en-aut-sei=Ono en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshidaMitsuru en-aut-sei=Yoshida en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshiiTadashi en-aut-sei=Ishii en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatohEtsuko en-aut-sei=Katoh en-aut-mei=Etsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MikiRyuji en-aut-sei=Miki en-aut-mei=Ryuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MurataKatsuyoshi en-aut-sei=Murata en-aut-mei=Katsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KakuHanae en-aut-sei=Kaku en-aut-mei=Hanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=2 en-affil= kn-affil=National Food Research Institute affil-num=3 en-affil= kn-affil=National Food Research Institute affil-num=4 en-affil= kn-affil=Forestry and Forest Products Research Institute affil-num=5 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=6 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=9 en-affil= kn-affil=Faculty of Agriculture, Meiji University affil-num=10 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=INNATE IMMUNE-RESPONSE kn-keyword=INNATE IMMUNE-RESPONSE en-keyword=TOLL-LIKE RECEPTOR-5 kn-keyword=TOLL-LIKE RECEPTOR-5 en-keyword=PV. TABACI kn-keyword=PV. TABACI en-keyword=POSTTRANSLATIONAL MODIFICATION kn-keyword=POSTTRANSLATIONAL MODIFICATION en-keyword=BACTERIAL FLAGELLIN kn-keyword=BACTERIAL FLAGELLIN en-keyword=STRUCTURAL-ANALYSIS kn-keyword=STRUCTURAL-ANALYSIS en-keyword=AMINO-ACIDS kn-keyword=AMINO-ACIDS en-keyword=GLYCOSYLATION kn-keyword=GLYCOSYLATION en-keyword=AERUGINOSA kn-keyword=AERUGINOSA en-keyword=IDENTIFICATION kn-keyword=IDENTIFICATION END start-ver=1.4 cd-journal=joma no-vol=190 cd-vols= no-issue=2 article-no= start-page=764 end-page=768 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of glycosylation on swimming ability and flagellar polymorphic transformation in Pseudomonas syringae pv. tabaci 6605 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The role of flagellin glycosylation on motility was investigated in Pseudomonas syringae pv. tabaci. The swimming activity of glycosylation-defective mutants was prominently decreased in a highly viscous medium. The mutants showed differences in polymorphic transitions and in the bundle formation of flagella, indicating that glycosylation stabilizes the filament structure and lubricates the rotation of the bundle.

en-copyright= kn-copyright= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataSatoshi en-aut-sei=Shibata en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukiTomoko en-aut-sei=Suzuki en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaYujiro en-aut-sei=Ogawa en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AizawaShin-Ichi en-aut-sei=Aizawa en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeuchiKasumi en-aut-sei=Takeuchi en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Life Science, Prefectural University of Hiroshima affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Department of Life Science, Prefectural University of Hiroshima affil-num=6 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=7 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=131 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20062 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A micro ultrasonic motor using a micro-machined cylindrical bulk PZT transducer en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In this paper, a micro ultrasonic motor using a micro-machined bulk piezoelectric transducer is introduced. The cylindrical shaped bulk piezoelectric transducer, a diameter of 0.8 mm and a height of 2.2 mm, was developed as stator transducer for traveling wave type ultrasonic motor. The transducer was made of lead zirconate titanate (PZT) bulk ceramics, and formed by micro machining, Ni plating and laser beam cutting process. Using this stator transducer, we have fabricated a cylindrical micro ultrasonic motor, a diameter of 2.0 mm and a height of 5.9 mm. We have also evaluated some characteristics and succeeded in driving the micro ultrasonic motor.

en-copyright= kn-copyright= en-aut-name=KandaTakefumi en-aut-sei=Kanda en-aut-mei=Takefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MakinoAkira en-aut-sei=Makino en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OnoTomohisa en-aut-sei=Ono en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzumoriKoichi en-aut-sei=Suzumori en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoritaTakeshi en-aut-sei=Morita en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurosawaMinoru Kuribayashi en-aut-sei=Kurosawa en-aut-mei=Minoru Kuribayashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=University of Tokyo affil-num=6 en-affil= kn-affil=Tokyo Institute of Technology en-keyword=Piezoelectric actuator kn-keyword=Piezoelectric actuator en-keyword=Ultrasonic motor kn-keyword=Ultrasonic motor en-keyword=Micro motor kn-keyword=Micro motor en-keyword=Bulk piezoelectric material kn-keyword=Bulk piezoelectric material en-keyword=Micro machining kn-keyword=Micro machining END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=1069 end-page=1070 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20054 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improvement of zone control induction heating equipment for high-speed processing of semiconductor en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In this paper, the effect of dividing into several small coil groups having different current and frequency on heating characteristics is investigated using FEM (finite element method). The heating characteristics of graphite of each coil is examined, and a useful information for controlling current and frequency, which realize the nearly uniform heating, is obtained.

en-copyright= kn-copyright= en-aut-name=MiyagiDaisuke en-aut-sei=Miyagi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitohAisya en-aut-sei=Saitoh en-aut-mei=Aisya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiNorio en-aut-sei=Takahashi en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UchidaNaoki en-aut-sei=Uchida en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OzakiKazuhiro en-aut-sei=Ozaki en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Mitsui Engineering & Shipbuilding Company Limited affil-num=5 en-affil= kn-affil=Mitsui Engineering & Shipbuilding Company Limited en-keyword=coils kn-keyword=coils en-keyword=electric current control kn-keyword=electric current control en-keyword=finite element analysis kn-keyword=finite element analysis en-keyword=frequency control kn-keyword=frequency control en-keyword=graphite kn-keyword=graphite en-keyword=induction heating kn-keyword=induction heating en-keyword=semiconductor device manufacture kn-keyword=semiconductor device manufacture END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1 article-no= start-page=2 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20052 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Convergence acceleration and accuracy improvement in power bus impedance calculation with a fast algorithm using cavity modes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Based on the cavity-mode model, we have developed a fast algorithm for calculating power bus impedance in multilayer printed circuit boards. The fast algorithm is based on a closed-form expression for the impedance Z matrix of a rectangular power bus structure; this expression was obtained by reducing the original double infinite series into a single infinite series under an approximation. The convergence of the single series is further accelerated analytically. The accelerated single summation enables much faster computation, since use of only a few terms is enough to obtain good accuracy. In addition, we propose two ways to compensate for the error due to the approximation involved in the process of reducing the double series to the single series, and have demonstrated that these two techniques are almost equivalent. en-copyright= kn-copyright= en-aut-name=WangZhi Liang en-aut-sei=Wang en-aut-mei=Zhi Liang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WadaOsami en-aut-sei=Wada en-aut-mei=Osami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyotaYoshitaka en-aut-sei=Toyota en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogaRyuji en-aut-sei=Koga en-aut-mei=Ryuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=Cavity-mode model kn-keyword=Cavity-mode model en-keyword=closed-form expression for fast calculation kn-keyword=closed-form expression for fast calculation en-keyword=power bus impedance kn-keyword=power bus impedance en-keyword=power bus kn-keyword=power bus en-keyword=resonance kn-keyword=resonance END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=538 end-page=542 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of response mechanism of a proton-pumping gate FET hydrogen gas sensor in air en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Two different types of hydrogen response signals (DC and AC) of a proton-pumping gate FET with triple layer gate structure (Pd/proton conducting polymer/Pt) were obtained. The proton-pumping gate FET showed good selectivity against other gases (CH4, C2H6, NH3, and O2). For practical use, the hydrogen response characteristics of the proton-pumping gate FET were investigated in air (a gaseous mixture of oxygen and nitrogen). The proton-pumping gate FET showed different hydrogen response characteristics in nitrogen as well as in air, despite the lack of oxygen interference independently. To clarify the response mechanism of the proton-pumping gate FET, a hydrogen response measurement was performed, using a gas flow system and electrochemical impedance spectroscopy. Consequently, the difference in response between nitrogen and air was found to be due to the hydrogen dissociation reaction and the interference with the proton transfer caused by the adsorbed oxygen on the upper Pd gate electrode

en-copyright= kn-copyright= en-aut-name=YamaguchiTomiharu en-aut-sei=Yamaguchi en-aut-mei=Tomiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakisawaMasanori en-aut-sei=Takisawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiwaToshihiko en-aut-sei=Kiwa en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaHironobu en-aut-sei=Yamada en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsukadaKeiji en-aut-sei=Tsukada en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University affil-num=4 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University affil-num=5 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University en-keyword=Field effect transistor (FET) kn-keyword=Field effect transistor (FET) en-keyword=Hydrogen sensor kn-keyword=Hydrogen sensor en-keyword=Proton-pumping gate kn-keyword=Proton-pumping gate en-keyword=Oxygen kn-keyword=Oxygen en-keyword=Electrochemical impedance spectroscopy (EIS) kn-keyword=Electrochemical impedance spectroscopy (EIS) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=24 article-no= start-page=5103 end-page=5111 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A theoretical interpretation of the chemical shift of Si-29 NMR peaks in alkali borosilicate glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Si-29-NMR, it has so far been accepted that the chemical shifts of Q(n) Species (SiO4 units containing n bridging oxygens) were equivalent between alkali borosilicate, and boron-free alkali silicate classes. In the sodium borosilicate glasses with low sodium content. however. a contradiction was confirmed in the estimation of alkali distributions B-11 NMR suggested that Na ions were entirely distributed to berate groups to form BO4 units, whereas a -90 ppm component Was also observed in Si-29-NMR spectra, which has been attributed to Q(3) species associated with a nonbridging oxygen (NBO). Then. cluster molecular orbital calculations were performed to interpret the -90 ppm component in the borosilicate, glasses. It Was found that a silicon atom which had two tetrahedral borons (B4) as its second nearest neighbors was similar in atomic charge and Si2p energy to the Q(3) species in boron-free alkali silicates. Unequal distribution of electrons in Si-O-B4 bridging bonds was also found. where much electrons Were localized oil the Si-O bonds. It was finally concluded that the Si-O-B4 bridges with narrow bond angle were responsible for the -90 ppm Si-29 component in the borosilicate glasses. There still remained another interpretation: the Q(3) species were actually present in the glasses. and NBOs in the Q(3) species were derived from the tricluster groups. such as (O3Si)O(BO3)(2). In the classes With low sodium content. however. it was concluded that the tricluster groups were not so abundant to contribute to the -90 ppm component. en-copyright= kn-copyright= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraMitsunori en-aut-sei=Nishimura en-aut-mei=Mitsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=short-range order kn-keyword=short-range order en-keyword=nuclear-magnetic-resonance kn-keyword=nuclear-magnetic-resonance en-keyword=mas-nmr kn-keyword=mas-nmr en-keyword=structural kn-keyword=structural en-keyword=groups kn-keyword=groups en-keyword=oxygen sites kn-keyword=oxygen sites en-keyword=ab-initio kn-keyword=ab-initio en-keyword=o-17 nmr kn-keyword=o-17 nmr en-keyword=b-11 kn-keyword=b-11 en-keyword=na20-b2-3-s1-2 kn-keyword=na20-b2-3-s1-2 en-keyword=spectroscopy kn-keyword=spectroscopy END start-ver=1.4 cd-journal=joma no-vol=147 cd-vols= no-issue=4 article-no= start-page=505 end-page=509 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phase transition of zircon at high P-T conditions en-subtitle= kn-subtitle= en-abstract= kn-abstract=In situ observations of the zircon-reidite transition in ZrSiO4 were carried out using a multianvil high-pressure apparatus and synchrotron radiation. The phase boundary between zircon and reidite was determined to be P (GPa) = 8.5 + 0.0017~(T-1200) (K) for temperatures between 1100-1900 K. When subducted slabs, including igneous rocks and sediments, descend into the upper mantle, zircon in the subducted slab transforms into reidite at pressures of about 9 GPa, corresponding to a depth of 270 km. Reidite found in an upper Eocene impact ejecta layer in marine sediments is thought to have been transformed from zircon by a shock event. The peak pressure generated by the shock event in this occurrence is estimated to be higher than 8 GPa. en-copyright= kn-copyright= en-aut-name=OnoShigeaki en-aut-sei=Ono en-aut-mei=Shigeaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FunakoshiKenichi en-aut-sei=Funakoshi en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakajimaYoichi en-aut-sei=Nakajima en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TangeYoshinori en-aut-sei=Tange en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatsuraTomoo en-aut-sei=Katsura en-aut-mei=Tomoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Institute for Frontier Research on Earth Evolution, Japan Marine Science & Technology Center affil-num=2 en-affil= kn-affil=Japan Synchrotron Radiation Research Institute affil-num=3 en-affil= kn-affil=Department of Earth and Planetary Sciences, Tokyo Institute of Technology affil-num=4 en-affil= kn-affil=Department of Earth and Planetary Sciences, Tokyo Institute of Technology affil-num=5 en-affil= kn-affil=Institute for Study of the Earth's Interior, Okayama University en-keyword=high-pressure phase kn-keyword=high-pressure phase en-keyword=kokchetav massif kn-keyword=kokchetav massif en-keyword=northern KAZAKSTAN; METAMORPHIC ROCKS; ZRSIO4; TRANSFORMATIONS; POLYMORPH; REIDITE; STATE; GPA kn-keyword=northern KAZAKSTAN; METAMORPHIC ROCKS; ZRSIO4; TRANSFORMATIONS; POLYMORPH; REIDITE; STATE; GPA END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=3 article-no= start-page=328 end-page=336 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070919 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Heat Storage Characteristics of Latent-Heat Microcapsule Slurry Using Hot Air Bubbles by Direct-Contact Heat Exchange en-subtitle= kn-subtitle= en-abstract= kn-abstract=

This study deals with the heat storage characteristics of latent-heat microcapsule slurry consisting of a mixture of fine microcapsules packed with latent-heat storage material and water. The heat storage operation for the latent-heat microcapsules was carried out by the direct-contact heat exchange method using hot air bubbles. The latent-heat microcapsule consisted of n-paraffin as a core latent-heat storage material and melamine resin as a coating substance. The relationship between the completion time of latent-heat storage and some parameters was examined experimentally. The nondimensional correlation equations for temperature efficiency, the completion time period of the latent-heat storage process and variation in the enthalpy of air through the microcapsule slurry layer were derived in terms of the ratio of microcapsule slurry layer height to microcapsule diameter, Reynolds number for airflow, Stefan number and modified Stefan number for absolute humidity of flowing air.

en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimMyoung-Jun en-aut-sei=Kim en-aut-mei=Myoung-Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HirofumiTsukamoto en-aut-sei=Hirofumi en-aut-mei=Tsukamoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=Latent-Heat Storage kn-keyword=Latent-Heat Storage en-keyword=Direct-Contact Heat Exchange kn-keyword=Direct-Contact Heat Exchange en-keyword=Paraffin kn-keyword=Paraffin en-keyword=Air kn-keyword=Air END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1 article-no= start-page=126 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070918 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Convective Instability in a Microemulsion Phase-Change-Material Slurry Layer en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In the present experimental study, the stability of Rayleigh-Benard convection has been investigated in rectangular enclosures filled with microemulsion Phase-Change-Material (PCM) slurry. The PCM slurry exhibited a pseudoplastic non-Newtonian fluid behavior. Hysteresis in convection was clearly observed while the PCM were in a solid phase and in phase changing. The critical Rayleigh number decreases with the PCM mass concentration while the PCM is in phase changing. The fluid temperature at the center of the enclosure showed a time-dependent oscillation during the transition from a heat conduction state to a convection state. The maximum Nusselt number has been observed for all of the slurries while the heating plate was controlled at a temperature that most of PCM was in phase changing.

en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DaiChuanshan en-aut-sei=Dai en-aut-mei=Chuanshan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Tianjin University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=Rayleigh-B?nard Convection kn-keyword=Rayleigh-B?nard Convection en-keyword=Microemulsion kn-keyword=Microemulsion en-keyword=Phase Change Material kn-keyword=Phase Change Material en-keyword=Convective Instability kn-keyword=Convective Instability en-keyword=Subcritical Convection kn-keyword=Subcritical Convection en-keyword=Hysteresis kn-keyword=Hysteresis END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=2 article-no= start-page=322 end-page=330 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sublimation Behavior of Annular Frost Layer by Impinging Jet Flow en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The present paper deals with a new method of defrosting using the frost sublimation phenomenon, which occurs below the triple point of water (273.16K, 610.5Pa). The present experimental study examines the mass transfer of the annular frost layer developed on a cooling pipe exposed to an impinging jet flow. The morphology of the frost layer during sublimation was observed using a digital video recorder. It was understood that the mass flux of the frost layer increased with increasing the jet flow velocity and the difference in the mass concentration of water vapor between the frost surface and the impinging jet flow. The non-dimensional correlation equations of mass transfer of defrosting were derived as functions of various parameters.

en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakamotoNaoki en-aut-sei=Takamoto en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawakamiYoshiaki en-aut-sei=Kawakami en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ImaiSeishi en-aut-sei=Imai en-aut-mei=Seishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Coil Division, Matsushita Refrigeration Co., Ltd en-keyword=Defrost kn-keyword=Defrost en-keyword=Frost Layer kn-keyword=Frost Layer en-keyword=Impinging Jet Flow kn-keyword=Impinging Jet Flow en-keyword=Sublimation kn-keyword=Sublimation en-keyword=Mass Transfer kn-keyword=Mass Transfer END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=1 article-no= start-page=183 end-page=191 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sorption Characteristics of Honeycomb-Type Sorption Element Composed of Organic Sorbent en-subtitle= kn-subtitle= en-abstract= kn-abstract=

This study deals with the sorption characteristics of a honeycomb-type sorption element composed of a new organic sorbent that was composed of the cross-linked polymer of sodium acrylate. Transient experiments in which moist air was passed into the honeycomb-type sorption element were conducted under various conditions of air velocity, temperature, relative humidity and honeycomb length. As a result, the effective mass transfer coefficient of the organic sorbent adsorbing the water vapor was non-dimensionalized as a function of Reynolds number, modified Stefan number and non-dimensional honeycomb length.

en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KidaTakahisa en-aut-sei=Kida en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanedaMakoto en-aut-sei=Kaneda en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Engineering Group, Engineering Division, Japan EXLAN Co., Ltd affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Engineering Group, Engineering Division, Japan EXLAN Co., Ltd en-keyword=Air Conditioning kn-keyword=Air Conditioning en-keyword=Sorption kn-keyword=Sorption en-keyword=Organic Sorbent kn-keyword=Organic Sorbent en-keyword=Water Vapor kn-keyword=Water Vapor en-keyword=Honeycomb Shape kn-keyword=Honeycomb Shape en-keyword=Mass Transfer kn-keyword=Mass Transfer END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=3 article-no= start-page=951 end-page=956 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050811 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Kinetic-spectrophotometric method for the determination of trace amounts of bromide in seawater en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel simple, sensitive and rapid kinetic-spectrophotornetric method is proposed for the determination of trace amounts of bromide. The method is based on its catalytic effect on the oxidation of methylene blue (MB) by hydrogen peroxide in strongly acidic solution. The oxidation reaction is activated by large amounts of chloride and can be monitored spectrophotometrically by measuring the decrease in the absorbance of MB at 746 run. The determination of bromide is performed by a fixed-time method at the first 100 s from the initiation of the reaction. Unlike other kinetic-spectrophotornetric methods for the determination of bromide, the proposed method does not require heating the solution. Bromide can be determined in the range from 80 to 960 mu g l(-1) with the detection limit of 35 mu g l(-1). The relative standard deviation of ten replicate determination of 480 mu g l(-1) bromide was 1.4%. The influence of potential interfering ions was studied. The proposed method was satisfactorily applied to the determination of bromide in seawater without interfering effect from chloride ion.

en-copyright= kn-copyright= en-aut-name=UraisinKanchana en-aut-sei=Uraisin en-aut-mei=Kanchana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=NacaprichaDuangjai en-aut-sei=Nacapricha en-aut-mei=Duangjai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Mahidol University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Kinetic-spectrophotometry kn-keyword=Kinetic-spectrophotometry en-keyword=Methylene blue kn-keyword=Methylene blue en-keyword=Bromide kn-keyword=Bromide en-keyword=Seawater kn-keyword=Seawater END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=2 article-no= start-page=388 end-page=393 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051013 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On-line preconcentration using dual mini-columns for the speciation of chromium(III) and chromium(VI) and its application to water samples as studied by inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

On-line preconcentration system for the selective, sensitive and simultaneous determination of chromium species was investigated. Dual minicolumns containing chelating resin were utilized for the speciation and preconcentration of Cr(III) and Cr(VI) in water samples. In this system, Cr(III) was collected on first column packed with iminodiacetate resin. Cr(VI) in the effluent from the first column was reduced to Cr(III), which was collected on the second column packed with iminodiacetate resin. Hydroxyammonium chloride was examined as a potential reducing agent for Cr(VI) to Cr(III). The effects of pH, sample flow rate, column length, and interfering ions on the recoveries of Cr(III) were carefully studied. Five millilitres of a sample solution was introduced into the system. The collected species were then sequentially washed by 1 M ammonium acetate, eluted by 2 M nitric acid and measured by ICP-AES. The detection limit for Cr(III) and Cr(VI) was 0.08 and 0.15 mu g l-1, respectively. The total analysis time was about 9.4 min. The developed method was successfully applied to the speciation of chromium in river, tap water and wastewater samples with satisfied results.

en-copyright= kn-copyright= en-aut-name=SumidaTakashi en-aut-sei=Sumida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkenoueTamami en-aut-sei=Ikenoue en-aut-mei=Tamami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaKazuhide en-aut-sei=Hamada en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=5 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=2 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=3 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=speciation kn-keyword=speciation en-keyword=chromium kn-keyword=chromium en-keyword=on-line preconcentration kn-keyword=on-line preconcentration en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=chelating resin kn-keyword=chelating resin END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=2 article-no= start-page=274 end-page=280 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Determination of trace amounts of bromide by flow injection/stopped-flow detection technique using kinetic-spectrophotometric method en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A simple, sensitive and selective method for the determination of bromide in seawater by using a flow injection/stopped-flow detection technique was examined. The detection system was developed for a new kinetic-spectrophotometric determination of bromide in the presence of chloride matrix without any extraction and/or separation. The detection was based on the kinetic effect of bromide on the oxidation of methylene blue (MB) with hydrogen peroxide in a strongly acidic solution. Large amounts of chloride could enhance the sensitivity of the method as an activator. The decolorisation of the blue color of MB was used for the spectrophotometric determination of bromide at 746 nm. A stopped-flow approach was used to improve the sensitivity of the measurement and provide good linearity of the calibration over the range of 0-3.2 p,g ml(-1) of bromide. The relative standard deviation was 0.74% for the determination of 2.4 jig ml(-1) bromide (n=5). The detection limit (3 sigma) was 0.1 mu g ml(-1) with a sampling frequency of 12 h(-1). The influence of potential interfering ions was studied. The proposed method was applied to the determination of bromide in seawater samples and provided satisfactory results.

en-copyright= kn-copyright= en-aut-name=UraisinK. en-aut-sei=Uraisin en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NacaprichaD. en-aut-sei=Nacapricha en-aut-mei=D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LapanantnoppakhunS. en-aut-sei=Lapanantnoppakhun en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GrudpanK. en-aut-sei=Grudpan en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Mahidol University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Stopped-flow injection kn-keyword=Stopped-flow injection en-keyword=Kinetic spectrophotometry kn-keyword=Kinetic spectrophotometry en-keyword=Methylene blue kn-keyword=Methylene blue en-keyword=Bromide kn-keyword=Bromide en-keyword=Seawater kn-keyword=Seawater END start-ver=1.4 cd-journal=joma no-vol=558 cd-vols= no-issue=1-2 article-no= start-page=246 end-page=253 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of a chitosan-based chelating resin and its application to the selective concentration and ultratrace determination of silver in environmental water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel chelating resin using chitosan as a base material, ethylenediamine-type chitosan, has been synthesized for the first time in the present study, and applied to the collection/concentration of ultratrace amounts of silver in environmental water samples. In the present study, ultratrace amounts of silver collected on the resin were eluted and determined by ICP-MS. The resin packed in a 1 mL mini column could adsorb silver selectively and quantitatively at a flow rate of 2 mL min(-1) in the wide pH range from 1 to 8, and silver adsorbed on the resin could be easily recovered by passing 1 M nitric acid as an eluent into the column. High adsorption capacity for silver at pH 5, 0.37 mmol mL(-1) of the resin, was achieved, and t(1/2) of the adsorption is less than 5 min. The effect of chloride on the collection of silver was examined by varying chloride concentrations from 10(-4) to 0.75 M; the results showed that the present resin can be used for the collection/concentration of ultratrace amounts of silver in natural waters, as well as seawater. To ensure the accuracy and the precision of the method, CASS-4 near shore seawater reference material from the NRCC has been analyzed. This is not a certified SRM for silver, but has been used for comparative silver analysis by several groups, who report very similar results to those that are reported here. The developed method using ethylenediamine-type chitosan resin gives 0.7 pg mL(-1) of the detection limit when 50-fold enrichment was used. The proposed method was successfully applied to the determination of silver in tap, river, and seawater samples. en-copyright= kn-copyright= en-aut-name=KatarinaRosi Ketrin en-aut-sei=Katarina en-aut-mei=Rosi Ketrin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Chelating resin kn-keyword=Chelating resin en-keyword=Chitosan kn-keyword=Chitosan en-keyword=Determination of silver kn-keyword=Determination of silver en-keyword=Environmental water samples kn-keyword=Environmental water samples en-keyword=ICP-MS kn-keyword=ICP-MS END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=3 article-no= start-page=263 end-page=268 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Trace and ultratrace analysis of purified water samples and hydrogen peroxide solutions for phosphorus by flow-injection method en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A highly sensitive fluorescence-quenching method for the determination of phosphorus based on the formation of an ion associate between molybdophosphate and Rhodamine B (RB) was developed. A simple flow-injection system coupled with a fluorescence detector was used to measure the fluorescence intensity at 560 nm and 580 nm as an excitation and an emission wavelength, respectively. The calibration graph for phosphorus showed a good linearity in the range of (0-1) x 10(-7) M (1 M = 1 mol L-1), and a detection limit of I x 10(-9) M (SIN = 3). The proposed method was successfully applied to the determination of ultratrace amounts of phosphorus in ultrapurified and purified water samples, and to the determination of trace amounts of phosphorus in commercially-available hydrogen peroxide solutions with satisfactory results. en-copyright= kn-copyright= en-aut-name=LiZenhai en-aut-sei=Li en-aut-mei=Zenhai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=6 article-no= start-page=1277 end-page=1285 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030829 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel flow injection-fluorometric method for the determination of trace silicate and its application to ultrapurified water analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A highly sensitive fluorescence quenching method for the determination of silicate based on the formation of an ion associate between molybdosilicate and Rhodamine B (RB) in nitric acid medium was developed. A flow injection system coupled with a fluorescence detector was used for the measurement of fluorescence intensity at 560 and 580 nm as excitation and emission wavelengths, respectively. The calibration graph for Si showed a linear range of 0.1-5 ng cm(-3) with correlation coefficient of 0.9999, and the detection limit of 0.06 ng cm(-3). The proposed method was successfully applied to the determination of silicate in ultrapurified water with satisfactory results.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=IshiiNaoe en-aut-sei=Ishii en-aut-mei=Naoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Laboratory Water Division, Nihon Millipore Ltd affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=ultrapurified water kn-keyword=ultrapurified water en-keyword=ion associate kn-keyword=ion associate en-keyword=molybdosilicate kn-keyword=molybdosilicate en-keyword=rhodamine B kn-keyword=rhodamine B en-keyword=flow injection kn-keyword=flow injection en-keyword=fluorescence quenching kn-keyword=fluorescence quenching END start-ver=1.4 cd-journal=joma no-vol=581 cd-vols= no-issue=2 article-no= start-page=214 end-page=220 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070109 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functionalization of chitosan with 3,4-dihydroxybenzoic acid for the adsorption/collection of uranium in water samples and its determination by inductively coupled plasma-mass spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A chitosan resin derivatized with 3,4-dihydroxybenzoic acid moiety (CCTS-DHBA resin) was newly synthesized for the collection/concentration of trace uranium by using cross-linked chitosan (CCTS) as base material, and the adsorption behavior of uranium as well as 60 elements on the resin was examined by passing the sample solutions through a mini-column packed with the resin. After the elution of the collected elements on the resin with 1M HNO3, the eluates were measured by inductively coupled plasma-mass spectrometry (ICP-MS). The CCTS-DHBA resin can adsorb several metal cations and several oxoanionic elements at appropriate pH. Among these metal ions, uranium shows an excellent adsorption behavior on this resin. Uranium as UO22+ species can be adsorbed on the resin by chelating mechanism with adsorption capacity of 330 mg g(-1) resin. Through the column treatment, the complete removal of large amounts of alkali and alkaline earth matrices without any loss of adsorption efficiency over prolonged usage were achieved with this resin. The CCTS-DHBA resin was applied to the adsorption/collection of uranium in tap water, river water and seawater samples with satisfactory results. The validation of the proposed method was carried out by analyzing uranium in the standard reference materials of SLRS-4, CASS-4, and NASS-5 after passing through the CCTS-DHBA resin, and the results showed good agreement with the certified values. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GaoYun Hua en-aut-sei=Gao en-aut-mei=Yun Hua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of International Conservation Studies, Faculty of International and Industrial Studies, Kibi International University affil-num=6 en-affil= kn-affil=Technical Institute of Physics and Chemistry, Chinese Academy of Sciences affil-num=7 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Chitosan resin kn-keyword=Chitosan resin en-keyword=3,4-dihydroxybenzoic acid kn-keyword=3,4-dihydroxybenzoic acid en-keyword=Uranium kn-keyword=Uranium en-keyword=Adsorption kn-keyword=Adsorption en-keyword=Water kn-keyword=Water en-keyword=Inductively coupled plasma-mass spectrometry kn-keyword=Inductively coupled plasma-mass spectrometry END start-ver=1.4 cd-journal=joma no-vol=588 cd-vols= no-issue=1 article-no= start-page=73 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of novel chitosan resin derivatized with serine diacetic acid moiety and its application to on-line collection/concentration of trace elements and their determination using inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel chelating resin functionalized with serine diacetic acid moiety was synthesized by using chitosan as base material, and applied to the collection/concentration of trace elements in environmental water samples, followed by the determination using inductively coupled plasma-atomic emission spectrometer (ICP-AES). The synthesized resin, crosslinked chitosan serine diacetic acid (CCTS-SDA), showed good adsorption behavior toward trace amounts of Cd, Pb, Cu, Ni, V, Ga, Sc, In, and Th in a wide pH range. Additionally, rare earth elements also can be retained on the resin at neutral pH region. The adsorbed elements can be easily eluted with 1 mol L-1 of nitric acid, and their recoveries were found to be 90-100%. The CCTS-SDA was packed in a mini-column, which was then installed in a cornputer-controlled auto-pretreatment system (Auto-Pret System) for on-line trace elements collection and determination with ICP-AES. Experimental parameters which related to the improvement of sensitivity and reproducibility were optimized. The limits of detection (LOD) for 13 elements were found to be in sub-ppb level. The proposed method with CCTS-SDA resin was successfully applied to the determination of trace elements in river water samples. The method was validated by determining a certified reference material of river water, SLRS-4. en-copyright= kn-copyright= en-aut-name=LukmanHakim en-aut-sei=Lukman en-aut-mei=Hakim kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chelating resin kn-keyword=chelating resin en-keyword=chitosan kn-keyword=chitosan en-keyword=serine diacetic acid moiety kn-keyword=serine diacetic acid moiety en-keyword=trace elements kn-keyword=trace elements en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic emission spectrometry kn-keyword=inductively coupled plasma-atomic emission spectrometry en-keyword=SLRS-4 kn-keyword=SLRS-4 END start-ver=1.4 cd-journal=joma no-vol=532 cd-vols= no-issue=1 article-no= start-page=27 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Slope comparison method (SCM) for the determination of trace amounts of silicate in ultrapurified water en-subtitle= kn-subtitle= en-abstract= kn-abstract=A sensitive analytical method for the determination of trace amounts of silicate in ultrapurified water was developed. The method is based on the formation of an ion associate of molybdosilicate with malachite green (MG) and the collection of the ion associate on a tiny membrane filter (diameter: 5 mm, and effective filtering diameter: 1 mm). The ion associate formed on the membrane filter is dissolved together with the membrane filter in 1 ml of methyl cellosolve (MC) and the absorbance of MC solution is measured at 627 nm by a flow injection-spectrophotometric detection technique. In this method, silicate in the original sample (ultrapurified water) is concentrated as the ion associate into a small volume of MC to get high sensitivity. As sample concentration takes place, the small amounts of silicate contained in the reagents used also become concentrated as the ion associate into MC. The original sample volumes are varied and evaporated to an identical volume. Therefore, the reagent added is fixed to the same volume. The absorbance increase linearly with increase in the original sample volume will be due only to silicate in the original samples (ultrapurified water). The resulting slopes obtained by varying the sample volumes are compared with the slope of the calibration graph, and thus named the slope comparison method (SCM). The SCM facilitates a more sensitive and accurate evaluation of silicate concentration in the samples than either common calibration method (CCM) or standard addition method (SAM) because it compensates for the influence of trace amounts of silicate contained in chemicals, reagent solution and solvent used. The calibration graph was constructed from 0 to 0.25 ng ml(-1) of Si and the detection limit was 10 pg ml(-1) (ppt) when 30 ml of samples was used. The standard deviation and relative standard deviation from six measurements of the reagent blanks were 0.0012 and 3.5%, respectively. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=slope comparison method kn-keyword=slope comparison method en-keyword=ultrapurified water kn-keyword=ultrapurified water en-keyword=ion associate kn-keyword=ion associate en-keyword=molybdosilicate kn-keyword=molybdosilicate en-keyword=malachite green kn-keyword=malachite green en-keyword=membrane filter kn-keyword=membrane filter END start-ver=1.4 cd-journal=joma no-vol=542 cd-vols= no-issue=2 article-no= start-page=207 end-page=215 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of chitosan resin possessing 3,4-diamino benzoic acid moiety for the collection/concentration of arsenic and selenium in water samples and their measurement by inductively coupled plasma-mass spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A chitosan resin functionalized with 3,4-diamino benzoic acid (CCTS-DBA resin) was newly synthesized by using a cross-linked chitosan (CCTS) as base material. The adsorption behavior of trace amounts of elements on the CCTS-DBA resin was examined by the pretreatment with a mini-column and measurement of the elements by inductively coupled plasma-Mass spectrometry (ICP-MS). Arsenic(V) could be retained on the CCTS-DBA resin at pH 3 as an oxoanion of H(2)ASO(4)(-). Selenium(VI) is strongly adsorbed at pH 2 and pH 3 as an oxoanion of SeO42-. while selenium(IV) as HSeO3- is adsorbed on the resin at pH 3. The sorption capacities are 82, 64, and 88 mg g(-1) resin for As(V), Se(IV), and Se(VI), respectively. The effect of common anions and cations on the adsorption of As(V), Se(IV), and Se(VI) were studied; there was no interference from such anionic matrices as chloride, sulfate, phosphate, and nitrate up to 20 ppm, as well as from such artificial river water matrices as Na, K, Mg, and Ca after passing samples through the mini-column containing the resin. The CCTS-DBA resin was applied to the collection of arsenic and selenium species in bottled drinking water, tap water, and river water. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Cross-linked chitosan kn-keyword=Cross-linked chitosan en-keyword=3,4-diamino benzoic acid kn-keyword=3,4-diamino benzoic acid en-keyword=Arsenic kn-keyword=Arsenic en-keyword=Selenium kn-keyword=Selenium en-keyword=ICP-MS kn-keyword=ICP-MS END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page=1675 end-page=1680 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flow-Injection Spectrofluorometric Determination of Trace Amounts of Formaldehyde in Water after Derivatization with Acetoacetanilide en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel fluorophotometric method for formaldehyde determination in environmental waters was developed: the method does not require any enrichment procedures. A flow-injection analysis method for the spectrofluorometric determination of formaldehyde in waters, which is based on the reaction of formaldehyde with acetoacetanilide and ammonia, is proposed. The proposed method shows a good linearity from 0.50 to 40 x 10(-7) M, and the limit of detection (LOD) of 3 x 10(-9) M (0.09 ppb) is achievable. The sample throughput is 15 h(-1). One of the main advantages in the proposed method is that the reaction can be carried out at room temperature without any heating system. The effect of various interferences possibly present in the real water samples was investigated. Most cations and anions, as well as organic compounds, do not interfere with the determination of formaldehyde in environmental water samples. The proposed method is very simple, rapid, less expensive, and highly sensitive, and can be applied to the environmental water samples, such as rain, tap water and river water, at low concentration levels without any enrichment procedure.

en-copyright= kn-copyright= en-aut-name=LiQiong en-aut-sei=Li en-aut-mei=Qiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Spectrofluorometric kn-keyword=Spectrofluorometric en-keyword=Water samples kn-keyword=Water samples en-keyword=Flow-injection kn-keyword=Flow-injection en-keyword=Formaldehyde determination kn-keyword=Formaldehyde determination en-keyword=Acetoacetanilide kn-keyword=Acetoacetanilide END start-ver=1.4 cd-journal=joma no-vol=579 cd-vols= no-issue=1 article-no= start-page=33 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A membraneless gas diffusion unit: Design and its application to determination of ethanol in liquors by spectrophotometric flow injection en-subtitle= kn-subtitle= en-abstract= kn-abstract=This work presents new design of a gas diffusion unit, called 'membraneless gas diffusion (MGD) unit', which, unlike a conventional gas diffusion (GD) unit, allows selective detection of volatile compounds to be made without the need of a hydrophobic membrane. A flow injection method was developed employing the MGD unit to determine ethanol in alcoholic drinks based on the reduction of dichromate by ethanol vapor. Results clearly demonstrated that the MGD unit was suitable for determination of ethanol in beer, wine and distilled liquors. Detection limit (3S/N) of MGD unit was lower than the GD unit (GD: 0.68%, v/v; MGD: 0.27%, v/v). The MGD design makes the system more sensitive as mass transfer is more efficient than that of GD and thus, MGD can perfectly replace membrane-based designs. en-copyright= kn-copyright= en-aut-name=ChoengchanN. en-aut-sei=Choengchan en-aut-mei=N. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MantimT. en-aut-sei=Mantim en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WilairatP. en-aut-sei=Wilairat en-aut-mei=P. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DasguptaP. K. en-aut-sei=Dasgupta en-aut-mei=P. K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= en-aut-name=NacaprichaD. en-aut-sei=Nacapricha en-aut-mei=D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=2 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=3 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=4 en-affil= kn-affil=Department of Chemistry and Biochemistry, Texas Tech University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University en-keyword=membraneless gas diffusion kn-keyword=membraneless gas diffusion en-keyword=flow injection kn-keyword=flow injection en-keyword=ethanol determination kn-keyword=ethanol determination en-keyword=liquor kn-keyword=liquor en-keyword=spectrophotometry kn-keyword=spectrophotometry END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=1256 end-page=1260 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080523 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of chitosan-based resins modified with tris(2-aminoethyl)amine moiety and its application to collection/concentration and determination of trace mercury by inductively coupled plasma atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel chitosan-based chelating resin modified with tris(2-aminoethyl)amine moiety (CCTS-TAA) was synthesized. and its characteristics in the collection/concentration of mercury was examined. The synthesized resin showed good adsorption toward mercury in a wide pH range, and the adsorbed mercury can be easily eluted by using 2 M HNO3 without any addition of complexing agent. The resin was then packed in a mini-column and the mini-column was installed on a computer-controlled automated-pretreatment (Auto-Pret) system coupled with inductively coupled plasma-atomic emission spectroscopy (ICP-AES) for on-line mercury collection and determination at trace level.

en-copyright= kn-copyright= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=resin kn-keyword=resin en-keyword=chitosan kn-keyword=chitosan en-keyword=tris(2-aminoethyl)amine moiety kn-keyword=tris(2-aminoethyl)amine moiety en-keyword=mercury kn-keyword=mercury en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic kn-keyword=inductively coupled plasma-atomic en-keyword=emission spectrometry kn-keyword=emission spectrometry END start-ver=1.4 cd-journal=joma no-vol=1069 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Capillary zone electrophoretic studies of ion association between inorganic anions and tetraalkylammonium ions in aqueous-dioxane media en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Ion association between inorganic anions and symmetrical tetraalkylammonium ions, R4N+ (R = Me, Et, Pr, n-Bu, n-Am, and 2-methyl butyl {isoamyl = iAm}) was investigated using ordinary silica capillary by capillary zone electrophoresis. An improved version of the Williams-Vigh method was used for the first time to measure the mobilities of the inorganic anions. Plots of log K-ass against log dielectric constant in various media, revealed a smaller change in K-ass compared to dielectric constant. These plots suggest that the Bjerrum's equation is inadequate in accounting for the associations of ions in a CZE setup.

en-copyright= kn-copyright= en-aut-name=MbunaJulius en-aut-sei=Mbuna en-aut-mei=Julius kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=aqueous-dioxane media kn-keyword=aqueous-dioxane media en-keyword=Williams-Vigh method kn-keyword=Williams-Vigh method en-keyword=ion association kn-keyword=ion association en-keyword=capillary zone electrophoresis kn-keyword=capillary zone electrophoresis END start-ver=1.4 cd-journal=joma no-vol=620 cd-vols= no-issue=1-2 article-no= start-page=50 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080714 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A caffeine-sensitive membrane electrode: Previous misleading report and present approach en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although a previous study [S.S.M. Hassan, M.A. Ahmed, M.M. Saoudi, Anal. Chem. 57 (1985) 1126] had shown that a caffeine-sensitive electrode made with picrylsulfonate and 1-octanol as a cation-exchanger and a solvent mediator, respectively, had a wide working pH range (5.5-9.5) and exhibited a Nernstian response, we could not find such response in this electrode. The present result was reasonable, because the pK, value of caffeinium ion was reported to be around 0.7 and the neutral form of caffeine was predominant in the pH range examined. Thus, we reinvestigated the response characteristics of a caffeine electrode, taking into consideration the pKa value, and constructed a new electrode with a combination of the lipophilic cation-exchanger, tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate (HFPB), and the solvent mediator with high degree of dielectric constant, 2-fluoro-2'-nitrodiphenyl ether (FNDPE). This electrode showed a pH-dependent response to caffeinium ion and gave a detection limit of 50 mu M with a slope of 55 mV per concentration decade at pH 2. The use of other solvent mediators was less effective than that of FNDPE. The electrode was applied for the determination of caffeine in some central stimulants. en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunamotoYumi en-aut-sei=Tsunamoto en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaniokaNobumitsu en-aut-sei=Hanioka en-aut-mei=Nobumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NarimatsuShizuo en-aut-sei=Narimatsu en-aut-mei=Shizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=ion-selective electrode kn-keyword=ion-selective electrode en-keyword=caffeinium ion kn-keyword=caffeinium ion en-keyword=solvent mediator kn-keyword=solvent mediator en-keyword=2-fluoro-2 '-nitrodiphenyl ether kn-keyword=2-fluoro-2 '-nitrodiphenyl ether en-keyword=caffeine determination kn-keyword=caffeine determination END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=977 end-page=985 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070819 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan functionalized with threonine moiety and its application to on-line collection/concentration and determination of Mo, V and Cu en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel chitosan-based resin functionalized with threonine moiety was synthesized, and applied to the collection/concentration of Mo, V and Cu in environmental water samples, followed by their determination using inductively coupled plasma-atomic emission spectrometer (ICP-AES). The synthesized resin, cross-linked chitosan-threonine (CCTS-Thr), showed good adsorption behavior toward trace amounts of Mo, V and Cu in a wide pH range. The adsorbed elements can be easily eluted using 2 mol L-1 of nitric acid, and their recoveries were found to be 90-100%. The CCTS-Thr was packed in a mini-column, which was then installed in a computer-controlled auto-pretreatment system (Auto-Pret System) for on-line trace elements collection and determination by ICP-AES. Experimental parameters related to the improvement of sensitivity and reproducibility were optimized. The limits of detection (LODs) for target metals were found to be in sub-ppb level. The proposed method with CCTS-Thr resin was successfully applied to the determination of Mo, V and Cu in environmental water samples. The recovery test showed that common matrices which exist in environmental water samples did not interfere with the determination.

en-copyright= kn-copyright= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=resin kn-keyword=resin en-keyword=chitosan kn-keyword=chitosan en-keyword=threonine moiety kn-keyword=threonine moiety en-keyword=molybdenum kn-keyword=molybdenum en-keyword=vanadium kn-keyword=vanadium en-keyword=copper kn-keyword=copper en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic emission spectrometry kn-keyword=inductively coupled plasma-atomic emission spectrometry END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=831 end-page=837 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070522 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functionalization of chitosan with 3-nitro-4-amino benzoic acid moiety and its application to the collection/concentration of molybdenum in environmental water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chitosan resin functionalized with 3-nitro-4-amino benzoic acid moiety (CCTS-NABA resin) was newly synthesized for the collection/concentration of trace molybdenum by using cross-linked chitosan (CCTS) as base material. The carboxyl group of the moiety was chemically attached to amino group of cross-linked chitosan through amide bond formation. The adsorption behavior of molybdenum as well as other 60 elements on the resin was examined by passing the sample solutions through a mini-column packed with the resin. After the elution of the elements collected on the resin with 1 M HNO3, the eluates were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) and atomic emission spectrometry (ICP-AES).
The CCTS-NABA resin can adsorb several metal ions, such as vanadium, gallium, arsenic, selenium, silver, bismuth, thorium, tungsten, tin, tellurium, copper, and molybdenum at appropriate pHs. Among these metal ions, only molybdenum could be adsorbed almost completely on the resin at acidic regions. An excellent selectivity toward molybdenum could be obtained at pH 3-4. The adsorption capacity of CCTS-NABA resin for Mo(VI) was 380 mg g(-1) resin. Through the column pretreatment, alkali and alkaline earth metals in river water and seawater samples were successfully removed.
The CCTS-NABA resin was applied to the adsorption/collection of molybdenum in river water and seawater samples. The concentrations of molybdenum in river water samples were found in the range of 0.84 and 0.95 ppb (ng g(-1)), whereas molybdenum in seawater was about 9 ppb. The validation of the proposed method was carried out by determining molybdenum in the certified reference materials of SLRS-4, CASS-4, and NASS-5 after passing through the CCTS-NABA resin; the results showed good agreement with the certified-values.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=NoguchiOsamu en-aut-sei=Noguchi en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Brawijaya University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chitosan resin kn-keyword=chitosan resin en-keyword=3-nitro-4-amino benzoic acid kn-keyword=3-nitro-4-amino benzoic acid en-keyword=molybdenum kn-keyword=molybdenum en-keyword=adsorption behavior kn-keyword=adsorption behavior en-keyword=water and seawater kn-keyword=water and seawater en-keyword=ICP-MS kn-keyword=ICP-MS en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=certified reference materials kn-keyword=certified reference materials END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=5 article-no= start-page=1259 end-page=1265 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Simple flow-injection system for the simultaneous determination of nitrite and nitrate in water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel spectrophotometric reaction system was developed for the determination of nitrite as well as nitrate in water samples, and was applied to a flow-injection analysis (FIA). The spectrophotometric flow-injection system coupled with a copperised cadmium reductor column was proposed. The detection was based on the nitrosation reaction between nitrite ion and phloroglucinol (1,3,5-trihydroxybenzene), a commercially available phenolic compound. Sample injected into a carrier stream was split into two streams at the Y-shaped connector. One of the streams merged directly and reacted with the reagent stream: nitrite ion in the samples was detected. The other stream was passed through the copperised cadmium reductor column, where the reduction of nitrate to nitrite occurred, and the sample zone was then mixed with the reagent stream and passed through the detector: the sum of nitrate and nitrite was detected. The optimised conditions allow a linear calibration range of 0.03-0.30 mug NO2--N ml(-1) and 0.10-1.00 mug NO3--N ml(-1). The detection limits for nitrite and nitrate, defined as three times the standard deviation of measured blanks are 2.9 ng NO2--N ml(-1) and 2.3 ng NO3--N ml(-1), respectively. Up to 20 samples can be analyzed per hour with a relative standard deviation of less than 1.5%. The proposed method could be applied successfully to the simultaneous determination of nitrite and nitrate in water samples.

en-copyright= kn-copyright= en-aut-name=BurakhamRodjana en-aut-sei=Burakham en-aut-mei=Rodjana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=GrudpanKate en-aut-sei=Grudpan en-aut-mei=Kate kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Flow-injection analysis kn-keyword=Flow-injection analysis en-keyword=Phloroglucinol kn-keyword=Phloroglucinol en-keyword=Nitrite kn-keyword=Nitrite en-keyword=Nitrate kn-keyword=Nitrate en-keyword=Simultaneous determination kn-keyword=Simultaneous determination END start-ver=1.4 cd-journal=joma no-vol=387 cd-vols= no-issue=6 article-no= start-page=2057 end-page=2064 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode en-subtitle= kn-subtitle= en-abstract= kn-abstract=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography. en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunamotoYumi en-aut-sei=Tsunamoto en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaniokaNobumitsu en-aut-sei=Hanioka en-aut-mei=Nobumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NarimatsuShizuo en-aut-sei=Narimatsu en-aut-mei=Shizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=Ion-selective electrode kn-keyword=Ion-selective electrode en-keyword=Mexiletine determination kn-keyword=Mexiletine determination en-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate kn-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate en-keyword=Solvent mediator kn-keyword=Solvent mediator en-keyword=Drug monitoring kn-keyword=Drug monitoring END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page=1609 end-page=1617 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070118 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sequential-injection on-line preconcentration using chitosan resin functionalized with 2-amino-5-hydroxy benzoic acid for the determination of trace elements in environmental water samples by inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A new chelating resin using chitosan as a base material was synthesized. Functional moiety of 2-amino-5-hydroxy benzoic acid (AHBA) was chemically bonded to the amino group of cross-linked chitosan (CCTS) through the arm of chloromethyloxirane (CCTS-AHBA resin). Several elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and rare earth elements (REEs), could be adsorbed on the resin. To use the resin for on-line pretreatment, the resin was packed in a mini-column and installed into a sequential-injection/automated pretreatment system (Auto-Pret System) coupled with inductively coupled plasma-atomic emission spectrometry (ICP-AES). The sequential-injection/automated pretreatment system was a laboratory-assembled, and the program was written using Visual Basic software. This system can provide easy operation procedures, less reagent consumption, as well as less waste production. Experimental variables considered as effective factors in the improvement sensitivity, such as an eluent concentration, a sample and an eluent flow rate, pH of samples, and air-sandwiched eluent were carefully optimized. The proposed system provides excellent on-line collection efficiency, as well as high concentration factors of analytes in water samples, which results in highly sensitive detection of ultra-trace and trace analysis. Under the optimal conditions, the detection limits of 24 elements examined are in the range from ppt to sub-ppb levels. The proposed method was validated by using the standard reference material of a river water, SLRS-4, and the applicability was further demonstrated to the on-line collection/concentration of trace elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and REEs in water samples.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LenghorNarong en-aut-sei=Lenghor en-aut-mei=Narong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GaoYun-Hua en-aut-sei=Gao en-aut-mei=Yun-Hua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS) affil-num=7 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=sequential-injection kn-keyword=sequential-injection en-keyword=on-line preconcentration kn-keyword=on-line preconcentration en-keyword=trace elements kn-keyword=trace elements en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=chitosan resin kn-keyword=chitosan resin END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=12 article-no= start-page=1431 end-page=1434 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adsorption behavior of cationic and anionic species on chitosan resins possessing amino acid moieties en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Chitosan resins modified with amino acids, such as glycine, valine, leucine, and serine, were synthesized for investigating the adsorption behavior of cationic and anionic species, and showed good abilities for the adsorption of trace elements in aquatic media as follows: glycine for lanthanoids at pH 7, leucine for molybdenum at pH 1 - 5, serine for uranium at pH 2 - 7, and amino acids for bismuth at pH 1 - 7. Cationic and anionic species could be adsorbed by a chelating mechanism and an anion-exchange mechanism.

en-copyright= kn-copyright= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of International Conservation Studies for Cultural Properties, Faculty of Cultural Properties, Kibi International University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=CHEMICALLY-MODIFIED CHITOSAN kn-keyword=CHEMICALLY-MODIFIED CHITOSAN en-keyword=SELECTIVE ADSORPTION kn-keyword=SELECTIVE ADSORPTION en-keyword=ICP-MS kn-keyword=ICP-MS en-keyword=COLUMN COLLECTION/CONCENTRATION kn-keyword=COLUMN COLLECTION/CONCENTRATION en-keyword=COMPLEXANE TYPES kn-keyword=COMPLEXANE TYPES en-keyword=PRECIOUS METALS kn-keyword=PRECIOUS METALS en-keyword=DERIVATIVES kn-keyword=DERIVATIVES en-keyword=ION kn-keyword=ION en-keyword=COPRECIPITATION kn-keyword=COPRECIPITATION en-keyword=COPPER(II) kn-keyword=COPPER(II) END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=10 article-no= start-page=1203 end-page=1208 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan modified with the glycine moiety for the collection/concentration of bismuth in aquatic samples for ICP-MS determination en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chelating resin, cross-linked chitosan modified with the glycine moiety (glycine-type chitosan resin), was developed for the collection and concentration of bismuth in aquatic samples for ICP-MS measurements. The adsorption behavior of bismuth and 55 elements on glycine-type chitosan resin was systematically examined by passing a sample solution containing 56 elements through a mini-column packed with the resin (wet volume; I ml). After eluting the elements adsorbed on the resin with nitric acid, the eluates were measured by ICP-MS. The glycine-type chitosan resin could adsorb several cations by a chelating mechanism and several oxoanions by an anion-exchange mechanism. Especially, the resin could adsorb almost 100% Bi(III) over a wide pH region from pH 2 to 6. Bismuth could be strongly adsorbed at pH 3, and eluted quantitatively with 10 ml of 3 M nitric acid. A column pretreatment method with the glycine-type chitosan resin was used prior to removal of high concentrations of matrices in a seawater sample and the preconcentration of trace bismuth in river water samples for ICP-MS measurements. The column pretreatment method was also applied to the determination of bismuth in real samples by ICP-MS. The LOD of bismuth was 0.1 pg ml(-1) by 10-fold column preconcentration for ICP-MS measurements. The analytical results for bismuth in sea and river water samples by ICP-MS were 22.9 +/- 0.5 pg ml(-1) (RSD, 2.2%) and 2.08 +/- 0.05 pg ml(-1) (RSD, 2.4%), respectively.

en-copyright= kn-copyright= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NoguchiOsamu en-aut-sei=Noguchi en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of International Conservation Studies for Cultural Properties, Faculty of Cultural Properties, Kibi International University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=6 article-no= start-page=669 end-page=682 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Automated online preconcentration system for the determination of trace amounts of lead using Pb-selective resin and inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

An automated sequential-injection online preconcentration system was developed for the determination of lead by inductively coupled plasma - atomic emission spectrometry (ICP-AES). The preconcentration of lead was performed with a minicolumn containing a lead-selective resin, Analig Pb-01, which was installed between a selection and a switching valve. In an acidic condition ( pH 1), lead could be adsorbed on the resin. The concentrated lead was afterward eluted with 25 mu L of 0.06 M nitrilotriacetic acid (NTA) solution ( pH 9) and was subsequently transported into the nebulizer of ICP-AES for quantification. The selectivity of the resin toward lead was examined using a solution containing a mixture of 61 elements. When a sample volume of 5 mL was used, the quantitative collection of lead ( >= 97%) was achieved, along with an enrichment factor of 19, a sampling frequency of 12 samples hr(-1), a detection limit of 70 pg mL(-1), and a lowest quantification limit of 100 pg mL(-1). The linear dynamic range was 0.1 to 5 ng mL(-1), and the relative standard deviation (n = 9) was 0.5% at a 5 ng mL(-1) Pb level. The detection limit of 30 pg mL(-1) and lowest quantification limit of 50 pg mL(-1) could be achieved when 10 mL of sample volume was used. The accuracy of the proposed method was validated by determining lead in the standard reference material of river water (SLRS-4), and its applicability to the determination of lead in environmental river water samples was demonstrated.

en-copyright= kn-copyright= en-aut-name=SabarudinA. en-aut-sei=Sabarudin en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LenghorN. en-aut-sei=Lenghor en-aut-mei=N. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LipingY. en-aut-sei=Liping en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FurushoY. en-aut-sei=Furusho en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Center Laboratory, Faculty of Science, JiangXi Agricultural University affil-num=4 en-affil= kn-affil=GL Sciences, Inc. affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=nline prdetermination of lead kn-keyword=nline prdetermination of lead en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=oeconcentration kn-keyword=oeconcentration en-keyword=Pb-selective resin kn-keyword=Pb-selective resin en-keyword=sequential injection kn-keyword=sequential injection END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=1 article-no= start-page=136 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan possessing N-methyl-D-glucamine moiety (CCTS-NMDG) for adsorption/concentration of boron in water samples and its accurate measurement by ICP-MS and ICP-AES en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chitosan resin derivatized with N-methyl-(D)-glucamine (CCTS-NMDG) was synthesized by using a cross-linked chitosan (CCTS) as base material. The N-methyl-D-glucamine (NMDG) moiety was attached to the amino group of CCTS through the arm of chloromethyloxirane. The adsorption behavior of 59 elements on the synthesized resin was systematically examined by using the resin packed in a mini-column, passing water samples through it and measuring the adsorbed elements in eluates by ICP-MS. The CCTS-NMDG resin shows high ability in boron sorption with the capacity of 0.61 mmol ml(-1) (= 2.1 mmol g(-1)). The sorption kinetics of this resin was faster than that of the commercially available resins. Other advantages of the synthesized resin are: (1) quantitative collection of boron at neutral pH regions; (2) complete removal of large amounts of matrices; (3) no loss of efficiency over prolonged usage; (4) effective collection of boron in wide range concentration using a mini column containing 1 ml resin; (5) complete elution of boron with 1 mol 1(-1) nitric acid. The resin was applied to the collection/concentration of boron in water samples. Boron in tap water and river water was found to be in the range of 6-8 mu g 1(-1). The limit of detection (LOD) of boron after pretreatment with CCTS-NMDG resin and measurement by ICP-MS was 0.07 mu g 1(-1) and the limit of quantification (LOQ) was 0. 14 mu g 1(-1) when the volume of each sample and eluent was 10 ml.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chitosan resin kn-keyword=chitosan resin en-keyword=N-methyl-D-glucamine kn-keyword=N-methyl-D-glucamine en-keyword=boron kn-keyword=boron en-keyword=adsorption kn-keyword=adsorption en-keyword=ICP-MS/AES kn-keyword=ICP-MS/AES END start-ver=1.4 cd-journal=joma no-vol=612 cd-vols= no-issue=2 article-no= start-page=165 end-page=172 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of novel detection reagent for simple and sensitive determination of trace amounts of formaldehyde and its application to flow injection spectrophotometric analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, a novel detection reagent for formaldehyde determination is proposed, and is applied to a simple and highly sensitive flow injection method for the spectrophotometric determination of formaldehyde. The method is based on the reaction of formaldehyde with methyl acetoacetate in the presence of ammonia. The increase in the absorbance of the reaction product was measured at 375 nm. An inexpensive light emitting diode (LED)based UV detector (375 nm) was, for the first time, used. Under the optimized experimental conditions, formaldehyde in an aqueous solution was determined over the concentration range from 0.25 to 20.0 x 10(-6) M with a liner calibration graph; the limit of detection (LOD) of 5 x 10(-8) M (1.5 mu g L-1) was possible. The relative standard deviation of 12 replicate measurements of 5 X 10(-6) M formaldehyde was 1.2%. Maximum sampling throughput was about 21 samples/h. The effect of potential interferences such as metals, organic compounds and other aldehyde was also examined. The analytical performance for formaldehyde determination was compared with those obtained by the conventional acetylacetone method, which uses visible absorption spectrophotometry. Finally, the proposed method was successfully applied to the determination of formaldehyde in natural water samples. en-copyright= kn-copyright= en-aut-name=LiQiong en-aut-sei=Li en-aut-mei=Qiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SritharathikhumPiyanete en-aut-sei=Sritharathikhum en-aut-mei=Piyanete kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Flow injection kn-keyword=Flow injection en-keyword=Formaldehyde determination kn-keyword=Formaldehyde determination en-keyword=Spectrophotometry kn-keyword=Spectrophotometry en-keyword=Methyl acetoacetate kn-keyword=Methyl acetoacetate en-keyword=UV-light emitting diode (LED) kn-keyword=UV-light emitting diode (LED) END start-ver=1.4 cd-journal=joma no-vol=134 cd-vols= no-issue=2 article-no= start-page=516 end-page=520 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Oxygen electrode as a new tool to evaluate hydroxyl radical-scavenging ability en-subtitle= kn-subtitle= en-abstract= kn-abstract=

An oxygen electrode was applied to determine hydroxyl radical ((OH)-O-center dot) levels for the first time. The method is based on the determination of (OH)-O-center dot generated by the Fenton reaction using the reaction of (OH)-O-center dot with a scavenger and the resulting radical consuming an oxygen molecule stoichiometrically. Thus, the (OH)-O-center dot-scavenging abilities of antioxidant reagents, as well as the concentration of (OH)-O-center dot, can be determined by the measurement of consumption of dissolved oxygen using an oxygen electrode. A good correlation between the present method and conventional colorimetry was obtained for the estimation of the (OH)-O-center dot-scavenging activities of antioxidants. Furthermore, the results correlated with the (OH)-O-center dot-scavenging rate constants of the reagents evaluated by a "cupric ion reducing antioxidant capacity (CUPRAC)" assay. We applied the present method to estimate the (OH)-O-center dot-scavenging abilities of commercially available alcoholic drinks.

en-copyright= kn-copyright= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakeuchiHiroaki en-aut-sei=Takeuchi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=Oxygen electrode kn-keyword=Oxygen electrode en-keyword=Oxygen consumption kn-keyword=Oxygen consumption en-keyword=Hydroxyl radical kn-keyword=Hydroxyl radical en-keyword=Hydroxyl radical-scavenger kn-keyword=Hydroxyl radical-scavenger en-keyword=Antioxidant kn-keyword=Antioxidant en-keyword=Alcoholic drink kn-keyword=Alcoholic drink END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=4 article-no= start-page=413 end-page=417 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of novel reagent for Hantzsch reaction for the determination of formaldehyde by spectrophotometry and fluorometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel reagent, acetoacetanilide (AAA), was introduced to the determination of formaldehyde based on Hantzsch reaction. A simple and highly sensitive fluorometric method was achieved by using AAA. The main advantages in the use of this reagent are: the reaction is carried out at room temperature without any heating system, the cyclization product based on Hantzsch reaction is soluble in water, and the product can be detected by spectrophotometry and fluorometry. The maximum absorption wavelength of the product occurs at 368 nm, and the maximum excitation and emission wavelengths are found at 370 and 470 nm, respectively. Several important experimental variables of the procedures were examined; particularly, the reaction temperature, reaction time, concentrations of reagents, and pH of the reagent solution were optimized for improving the detecting sensitivity. The calibration graph was linear in the range of 1 x 10(-7) -1 X 10(-6) M or much higher concentrations. The limit of detection (LOD), based on three times of the standard deviation of the reagent blank, was 2.0 x 10(-8) M. The proposed method was applied to the determination of formaldehyde in environmental water samples. Many foreign species commonly existing in water samples did not interfere with the determination of formaldehyde in the proposed method.

en-copyright= kn-copyright= en-aut-name=LiQiong en-aut-sei=Li en-aut-mei=Qiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SritharathikhunPiyanete en-aut-sei=Sritharathikhun en-aut-mei=Piyanete kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=5 article-no= start-page=1147 end-page=1150 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flow injection spectrophotometry coupled with a crushed barium sulfate reactor column for the determination of sulfate ion in water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A new type of a reactor column, a crushed BaSO4 reactor column used for the flow injection spectrophotometric determination of sulfate ion using the exchange reaction of sulfate ion and barium-dimethylsulfonazo III is proposed. The column is very simple and economical. It can be continuously used for 8 h before washing with water for repeated usage of at least 1 month. The procedure is sensitive. Application to various water samples was demonstrated.

en-copyright= kn-copyright= en-aut-name=BurakhamRodjana en-aut-sei=Burakham en-aut-mei=Rodjana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiguchiKeiro en-aut-sei=Higuchi en-aut-mei=Keiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=GrudpanKate en-aut-sei=Grudpan en-aut-mei=Kate kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=2 en-affil= kn-affil=FIA Instruments Co., Ltd. affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Sulfate kn-keyword=Sulfate en-keyword=Dimethylsulfonazo III kn-keyword=Dimethylsulfonazo III en-keyword=On-line reactor column kn-keyword=On-line reactor column en-keyword=Flow injection analysis kn-keyword=Flow injection analysis en-keyword=Spectrophotometry kn-keyword=Spectrophotometry END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=5 article-no= start-page=665 end-page=668 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adsorption Properties of Ionic Species on Cross-linked Chitosans Modified with Catechol and Salicylic Acid Moieties en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Catechol-type chitosan resin and salicylic acid-type chitosan resin were easily synthesized for use in estimating the adsorption behavior of 34 elements at pH 1 - 7 in aquatic media. The catechol-type chitosan resin could adsorb Cu(II) at pH 3 - 7, In(III) at pH 4 - 6, Pb(II) and lanthanoids at pH 5 - 7, and U(VI) at pH 4 - 7 more effectively than the salicylic acid-type chitosan resin and the cross-linked chitosan resin (base material). Adsorption ability was in the order: catechol-type chitosan resin > salicylic acid-type chitosan resin > cross-linked chitosan resin.

en-copyright= kn-copyright= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of International Conservation Studies for Cultural Properties, Faculty of Cultural Properties, Kibi International University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=CHEMICALLY-MODIFIED CHITOSAN kn-keyword=CHEMICALLY-MODIFIED CHITOSAN en-keyword=SELECTIVE ADSORPTION; ICP-MS kn-keyword=SELECTIVE ADSORPTION; ICP-MS en-keyword=COLUMN COLLECTION/CONCENTRATION kn-keyword=COLUMN COLLECTION/CONCENTRATION en-keyword=COMPLEXANE TYPES kn-keyword=COMPLEXANE TYPES en-keyword=PRECIOUS METALS kn-keyword=PRECIOUS METALS en-keyword=DERIVATIVES kn-keyword=DERIVATIVES en-keyword=COPRECIPITATION kn-keyword=COPRECIPITATION en-keyword=COPPER(II) kn-keyword=COPPER(II) en-keyword=BEHAVIOR kn-keyword=BEHAVIOR END start-ver=1.4 cd-journal=joma no-vol=481 cd-vols= no-issue=2 article-no= start-page=311 end-page=319 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ultratrace determination of phosphorus in ultrapurified water by a slope comparison method en-subtitle= kn-subtitle= en-abstract= kn-abstract=The analytical method for the determination of phosphorus in ultrapurified water was developed. Ultrapurified water was evaporated to concentrate phosphorus and the final sample volume for analysis was 10 ml. In 0.55 mol 1(-1) HCl, orthophosphate forms molybdophosphate, and then the molybdophosphate forms ion associate with Malachite Green (MG), which can be collected on a tiny membrane filter (diameter: 5 mm, and effective filtering diameter: 2 mm). After the ion associate on the membrane filter is dissolved together with the membrane filter in I ml of methyl cellosolve (MC), the absorbance of MC solution is measured at 627 nm by a flow injection-spectrophotometric detection technique. When 10 ml of the sample solution was used for the procedures and absorbance measurement, the calibration graph is linear up to about 500 ng 1(-1) of phosphorus and the detection limit was 8 ng 1(-1) (S/N = 3). For the determination of phosphorus in an ultrapurified water, 10-40 ml of sample solutions were transferred into poly(tetrafluoroethylene) (PTFE) beaker and evaporated to 5 ml or to dryness. To them, 0.003 mol 1(-1) HCl was added to get 10 ml of final solution, which was used as sample. Phosphate is determined by comparing the slope of the varied sample volume after evaporation/concentration with a slope of the standard calibration graph (a slope comparison method: SCM). The SCM enables to evaluate the concentration of phosphate in ultrapurified waters more sensitively and accurately. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=ultrapurified water kn-keyword=ultrapurified water en-keyword=evaporation/concentration kn-keyword=evaporation/concentration en-keyword=ion associate kn-keyword=ion associate en-keyword=molybdophosphate kn-keyword=molybdophosphate en-keyword=malachite green kn-keyword=malachite green en-keyword=slope comparison method kn-keyword=slope comparison method END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=4 article-no= start-page=493 end-page=498 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Electrochemical Analysis of Chloramphenicol Using Boron-doped Diamond Electrode Applied to a Flow-Injection System en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The electrochemical properties of chloramphenicol at a boron-doped diamond thin-film (BDD) electrode were studied using cyclic voltammetry. The highest current response of chloramphenicol was obtained with phosphate buffer, pH 6 (0.1 M) in 1% ethanol. The relationship between the concentration of chloramphenicol and the current response was linear over the range of 0.1 - 10 mM (R-2 = 0.9990). The amount of chloramphenicol was analyzed by flow-injection analysis. A thin-layer flow cell equipped with a BDD electrode was used as an amperometric detector, and experiments were carried out at -0.7 V (vs. Ag/AgCl). The linear relationship between the current response and the concentration of chloramphenicol in the range of 0.1 - 50 mu M (R-2 = 0.9948) and the limit of detection of 0.03 mu M (S/N = 3) were obtained. This method has been successfully applied to the determination of chloramphenicol in sterile eye drops and milk sample by the standard addition method. The average recoveries of chloramphenicol in eye drops were 98.0%, and the average recoveries of chloramphenicol from spiked milk were 93.9 - 103%.

en-copyright= kn-copyright= en-aut-name=ChuanuwatanakulSuchada en-aut-sei=Chuanuwatanakul en-aut-mei=Suchada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ChailapakulOrawon en-aut-sei=Chailapakul en-aut-mei=Orawon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=THIN-FILM ELECTRODE kn-keyword=THIN-FILM ELECTRODE en-keyword=TANDEM MASS-SPECTROMETRY kn-keyword=TANDEM MASS-SPECTROMETRY en-keyword=CAPILLARY-ZONE-ELECTROPHORESIS kn-keyword=CAPILLARY-ZONE-ELECTROPHORESIS en-keyword=LIQUID-CHROMATOGRAPHY kn-keyword=LIQUID-CHROMATOGRAPHY en-keyword=AMPEROMETRIC DETECTION kn-keyword=AMPEROMETRIC DETECTION en-keyword=PHOTOCHEMICAL-REACTION kn-keyword=PHOTOCHEMICAL-REACTION en-keyword=OXIDATION kn-keyword=OXIDATION en-keyword=PRODUCTS kn-keyword=PRODUCTS en-keyword=RESIDUES kn-keyword=RESIDUES en-keyword=CARBON kn-keyword=CARBON END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=1 article-no= start-page=161 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Speciation of chromium in seawater by ICP-AES with dual mini-columns containing chelating resin en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A method for the preconcentration and speciation of chromium in seawater was developed. On-line preconcentration and determination were carried out by using inductively coupled plasma atomic emission spectrometry (ICP-AES) with dual mini-columns containing a chelating resin. In this system, Cr(III) was collected on the first column. The effluent containing residual chromium from the first column was collected on the second column after passing through a reduction-switching unit, in which the reducing agent was introduced, or not, for the reduction of Cr(VI) to Cr(Ill). Cr(VI) was determined as the difference between the concentration of pre-reduced Cr(VI) and Cr(III) in the effluent from the first column. The detection limits for Cr(III) and Cr(VI) were 0.04 and 0.09 mu g l(-1), respectively.

en-copyright= kn-copyright= en-aut-name=SumidaTakashi en-aut-sei=Sumida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Kochi Prefectual Industrial Technology Center affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=ONLINE PRECONCENTRATION kn-keyword=ONLINE PRECONCENTRATION en-keyword=SPECTROMETRY kn-keyword=SPECTROMETRY END start-ver=1.4 cd-journal=joma no-vol=159 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=348 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070426 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Application of chitosan functionalized with 3,4-dihydroxy benzoic acid moiety for on-line preconcentration and determination of trace elements in water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Chitosan resin functionalized with 3,4-dihydroxy benzoic acid (CCTS-DHBA resin) was used as a packing material for flow injection (FI) on-line mini-column preconcentration in combination with inductively coupled plasma-atomic emission spectrometry (ICP-AES) for the determination of trace elements such as silver, bismuth, copper, gallium, indium, molybdenum, nickel, uranium, and vanadium in environmental waters. A 5-mL aliquot of sample (pH 5.5) was introduced to the minicolumn for the adsorption/preconcentration of the metal ions, and the collected analytes on the mini-column were eluted with 2 M HNO3, and the eluates was subsequently transported via direct injection to the nebulizer of ICP-AES for quantification. The parameters affecting on the sensitivity, such as sample pH, sample flow rate, eluent concentration, and eluent flow rate, were carefully examined. Alkali and alkaline earth metal ions commonly existing in river water and seawater did not affect the analysis of metals. Under the optimum conditions, the method allowed the determination of metal ions with detection limits of 0.08 ng mL(-1) (Ag), 0.9 ng mL(-1) (Bi), 0.07 ng mL(-1) (Cu), 0.9 ng mL(-1) (Ga), 0.9 ng mL(-1) (In), 0.08 ng mL(-1) (Mo), 0.09 ng mL(-1) (Ni), 0.9 ng mL(-1) (U), and 0.08 ng mL(-1) (V). By using 5 mL of sample solution, the enrichment factor and collection efficiency were 8-12 fold and 96-102%, respectively, whereas the sample throughput was 7 samples/hour. The method was validated by determining metal ions in certified reference material of river water (SLRS-4) and nearshore seawater (CASS-4), and its applicability was further demonstrated to river water and seawater samples.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NoguchiOsamu en-aut-sei=Noguchi en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=‘哇ŒõŽq kn-aut-sei=‘哇 kn-aut-mei=ŒõŽq aut-affil-num=3 ORCID= en-aut-name=HiguchiKeiro en-aut-sei=Higuchi en-aut-mei=Keiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=–{…¹“ñ kn-aut-sei=–{… kn-aut-mei=¹“ñ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=FIA Instruments Division, Ogawa and Co. affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=flow injection kn-keyword=flow injection en-keyword=chitosan resin kn-keyword=chitosan resin en-keyword=on-line preconcentration kn-keyword=on-line preconcentration en-keyword=3 kn-keyword=3 en-keyword=4-dihydroxy benzoic acid kn-keyword=4-dihydroxy benzoic acid en-keyword=ICP-AES kn-keyword=ICP-AES END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=5 article-no= start-page=517 end-page=522 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Simultaneous measurements of K+ and calcein release from liposomes and the determination of pore size formed in a membrane en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The changes induced by biologically active substances in the permeability to K+ and calcein of liposomes composed of egg phosphatidylcholine and cholesterol were measured simultaneously in order to rapidly screen the sizes of pores formed in a membrane, using different sized markers. The substances examined in the present study were classified into three types based on differences in the rates at which K+ and calcein were released. The first type released only K+, and included gramicidin A. The second type predominantly released K+, preceding the release of calcein, and included amphotericin B and nystatin. The third type, including antimicrobial peptides, such as gramicidin S, alamethicin, and melittin, and several membrane-active drugs, like celecoxib (non-steroidal anti-inflammatory drug), 1-dodecylazacycloheptan-2-one (named azone; skin permeation enhancer), and chlorpromazine (tranquilizer), caused the release of K+ and calcein simultaneously. Thus, the sizes of pores formed in a liposomal membrane increased in the following order: types one, two, and three. We determined the size more precisely by conducting an osmotic protection experiment, measuring the release of calcein in the presence of osmotic protectants of different sizes. The radii of pores formed by the second type, amphotericin B and nystatin, were 0.36 - 0.46 nm, while the radii of pores formed by the third type were much larger, 0.63 - 0.67 nm or more. The permeability changes induced by substances of the third type are discussed in connection with a transient pore formed in a lipid packing mismatch taking place during the phase transition of dipalmitoylphosphatidylcholine liposomes.

en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ImamuraTomonori en-aut-sei=Imamura en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizushimaTohru en-aut-sei=Mizushima en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=5 article-no= start-page=589 end-page=594 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Determination of trace heavy metals by sequential injection-anodic stripping voltammetry using bismuth film screen-printed carbon electrode en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A sequential injection-square-wave anodic stripping voltammetry (SIA-SWASV) is proposed for the simultaneous determination of Pb(II), Cd(II) and Zn(II), employing an in situ plated bismuth film screen-printed carbon electrode (Bi-SPCE) as a working electrode and hydrochloric acid as a supporting electrolyte. Bi(III) and analyte metal ions were on-line deposited onto a SPCE at -1.4 V vs. Ag/AgCl for 180 s. At a stopped flow, a square-wave voltammogram was recorded from -1.3 to 0 V vs. Ag/AgCl. The experimental conditions were optimized. Under the optimum conditions, the linear ranges were 0 - 70 mu g L-1 for Pb(II) and Cd(II), and 75 - 200 mu g L-1 for Zn(II). The limits of detection (S/N = 3) were obtained at concentrations as low as 0.89 mu g L-1 for Pb(II) and 0.69 mu g L-1 for Cd(II) for a 180-s deposition time. The proposed method was applied to the determination of Pb(II), Cd(II) and Zn(II) in water samples with satisfactory results.

en-copyright= kn-copyright= en-aut-name=ChuanuwatanakulSuchada en-aut-sei=Chuanuwatanakul en-aut-mei=Suchada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DungchaiWijitar en-aut-sei=Dungchai en-aut-mei=Wijitar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChailapakulOrawon en-aut-sei=Chailapakul en-aut-mei=Orawon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=DIAMOND THIN-FILM kn-keyword=DIAMOND THIN-FILM en-keyword=FLOW-INJECTION kn-keyword=FLOW-INJECTION en-keyword=PLATED CARBON; WATER SAMPLES; COPPER kn-keyword=PLATED CARBON; WATER SAMPLES; COPPER en-keyword=LEAD kn-keyword=LEAD en-keyword=ZINC kn-keyword=ZINC en-keyword=EXTRACTS kn-keyword=EXTRACTS en-keyword=CADMIUM kn-keyword=CADMIUM en-keyword= CD(II) kn-keyword= CD(II) END start-ver=1.4 cd-journal=joma no-vol=961 cd-vols= no-issue=2 article-no= start-page=179 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Periaxonal Net in the Zebrafish Central Nervous System en-subtitle= kn-subtitle= en-abstract= kn-abstract=We produced a monoclonal antibody, named A20, which specifically recognizes a 35 kDa protein and stains myelinated axons in zebrafish brain. The A20 antigen is located at the outside of the myelin layer of large axons, and comprises a fine meshwork composed of thin unit fibers about 1?2 ƒÊm in length and about 100?200 nm in thickness. The unit fibers form pentagonal and hexagonal structures, which further polymerize into an envelope structure on the axons. The A20 monoclonal antibody did not stain neuronal cell bodies nor synapses. Instead, the distribution of the A20 antigen was along axons, practically coincident with the distribution of myelin basic protein. The monoclonal antibody stained only axons in the central nervous system (CNS), and not the extracellular matrix surrounding Schwann cells. These results suggest that this antigenic meshwork (which we call the periaxonal net) is synthesized by oligodendrocytes. During the development of the zebrafish brain, the periaxonal net appeared after the formation of myelin on the axons. The periaxonal net developed first at the brain stem, then gradually appeared at the caudal end of the spinal cord. The thickness of the periaxonal net around the Mauthner axon changed during development. Although the thickness of the Mauthner axon continues to grow throughout life, the thickness of periaxonal net stopped growing at 6 months after fertilization. en-copyright= kn-copyright= en-aut-name=NakayasuHiroshi en-aut-sei=Nakayasu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArataNoriko en-aut-sei=Arata en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Biology, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Biology, Faculty of Science, Okayama University en-keyword=Oligodendrocyte kn-keyword=Oligodendrocyte en-keyword=Monoclonal antibody kn-keyword=Monoclonal antibody en-keyword=Extracellular matrix kn-keyword=Extracellular matrix en-keyword=Central nervous system kn-keyword=Central nervous system END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=1 article-no= start-page=8 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to identify tumor suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variants of the HELLS/ SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular function like chromatin remodeling. Variant 1 was an alternatively spliced isoform containing an insertion of a 44-ntd intronic sequence between exons 3 and 4, giving rise to a premature termination of translation. The expression of the variant 1 was detected exclusively in the lung cancer specimens (11 of 43 cases, 26%), but was not detected in corresponding normal tissues. D10S520 marker in the proximity of the HELLS/SMARCA6 gene showed prevalent allelic loss (41%) as compared with flanking markers (25-31%). These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading the lung cells to malignancy or its progression. en-copyright= kn-copyright= en-aut-name=YanoMasaaki en-aut-sei=Yano en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OuchidaMamoru en-aut-sei=Ouchida en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShigematsuHisayuki en-aut-sei=Shigematsu en-aut-mei=Hisayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaNoriyoshi en-aut-sei=Tanaka en-aut-mei=Noriyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IchimuraKoichi en-aut-sei=Ichimura en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KobayashiKazuyasu en-aut-sei=Kobayashi en-aut-mei=Kazuyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=InakiYasuhiko en-aut-sei=Inaki en-aut-mei=Yasuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TsukudaKazunori en-aut-sei=Tsukuda en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShimizuKenji en-aut-sei=Shimizu en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University affil-num=3 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=4 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Pathology, Graduate School of Medicine and Dentistry, Okayama University affil-num=6 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=7 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=8 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=9 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=10 en-affil= kn-affil=Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University affil-num=11 en-affil= kn-affil=Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University en-keyword=alternative splicing kn-keyword=alternative splicing en-keyword=HELLS kn-keyword=HELLS en-keyword=loss of heterozygosity kn-keyword=loss of heterozygosity en-keyword=lung cancer kn-keyword=lung cancer en-keyword=SMARCA6 kn-keyword=SMARCA6 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=14 article-no= start-page=2963 end-page=2970 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20046 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Differential localization of the centromere-specific proteins in the major centromeric satellite of Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The 180 bp family of tandem repetitive sequences, which constitutes the major centromeric satellite in Arabidopsis thaliana, is thought to play important roles in kinetochore assembly. To assess the centromere activities of the 180 bp repeats, we performed indirect fluorescence immunolabeling with antibodies against phosphorylated histone H3 at Serl0, HTR12 (Arabidopsis centromeric histone H3 variant) and AtCENP-C (Arabidopsis CENP-C homologue) for the A. thaliana cell cultures. The immunosignals from all three antibodies appeared on all sites of the 180 bp,repeats detected by fluorescence in situ hybridization. However, some of the 180 bp repeat clusters, particularly those that were long or stretched at interphase, were not fully covered with the signals from anti-HTR12 or AtCENP-C. Chromatin fiber immunolabeling clearly revealed that the centromeric proteins examined in this study, localize only at the knobs on the extended chromatin fibers, which form a limited part of the 180 bp clusters. Furthermore, outer HTR12 and inner phosphohistone H3 (Ser1O) localization at the kinetochores of metaphase chromosomes suggests that two kinds of histone H3 (a centromere variant and a phosphorylated form) might be linked to different roles in centromere functionality; the former for spindle-fiber attachment, and the latter for chromatid cohesion.

en-copyright= kn-copyright= en-aut-name=ShibataFukashi en-aut-sei=Shibata en-aut-mei=Fukashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MurataMinoru en-aut-sei=Murata en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Japan Science and Technology, Kawaguchi affil-num=2 en-affil= kn-affil=Okayama University en-keyword=180 bp repeat kn-keyword=180 bp repeat en-keyword=Arabidopsis thaliana kn-keyword=Arabidopsis thaliana en-keyword=Centromere kn-keyword=Centromere en-keyword=proteins kn-keyword=proteins en-keyword=Histone H3 kn-keyword=Histone H3 en-keyword=Phosphorylation kn-keyword=Phosphorylation END start-ver=1.4 cd-journal=joma no-vol=280 cd-vols= no-issue=1-2 article-no= start-page=47 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Versican is induced in infiltrating monocytes in myocardial infarction en-subtitle= kn-subtitle= en-abstract= kn-abstract=Versican, a large chondroitin sulfate proteoglycan, plays a role in conditions such as wound healing and tissue remodelling. To test the hypothesis that versican expression is transiently upregulated and plays a role in the infarcted heart, we examined its expression in a rat model of myocardial infarction. Northern blot analysis demonstrated increased expression of versican mRNA. Quantitative real-time RT-PCR analysis revealed that versican mRNA began to increase as early as 6 h and reached its maximal level 2 days after coronary artery ligation. Versican mRNA then gradually decreased, while the mRNA of decorin, another small proteoglycan, increased thereafter. Versican mRNA was localized in monocytes, as indicated by CD68-positive staining, around the infarct tissue. The induction of versican mRNA was accelerated by ischemia/reperfusion (I/R), which was characterized by massive cell infiltration and enhanced inflammatory response. To examine the alteration of versican expression in monocytes/macrophages, we isolated human peripheral blood mononuclear cells and stimulated them with granulocyte/macrophage colony-stimulating factor (GM-CSF). Stimulation of mononuclear cells with GM-CSF increased the expression of versican mRNA as well as cytokine induction. The production of versican by monocytes in the infarct area represents a novel finding of the expression of an extracellular matrix gene by monocytes in the infarcted heart. We suggest that upregulation of versican in the infarcted myocardium may have a role in the inflammatory reaction, which mediates subsequent chemotaxis in the infarcted heart. en-copyright= kn-copyright= en-aut-name=ToedaKenichi en-aut-sei=Toeda en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraKeigo en-aut-sei=Nakamura en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirohataSatoshi en-aut-sei=Hirohata en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HatipogluOmer F. en-aut-sei=Hatipoglu en-aut-mei=Omer F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DemircanKadir en-aut-sei=Demircan en-aut-mei=Kadir kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamawakiHitoshi en-aut-sei=Yamawaki en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OgawaHiroko en-aut-sei=Ogawa en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShiratoriYasushi en-aut-sei=Shiratori en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NinomiyaYoshifumi en-aut-sei=Ninomiya en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=2 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=3 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=4 en-affil= kn-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry affil-num=5 en-affil= kn-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry affil-num=6 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=7 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=8 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=9 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry affil-num=10 en-affil= kn-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry en-keyword=coronary artery disease kn-keyword=coronary artery disease en-keyword=cytokine kn-keyword=cytokine en-keyword=extracellular matrix kn-keyword=extracellular matrix en-keyword=GM-CSF kn-keyword=GM-CSF en-keyword=monocyte kn-keyword=monocyte END start-ver=1.4 cd-journal=joma no-vol=126B cd-vols= no-issue=1 article-no= start-page=43 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association between the Glutathione S-transferase M1 gene deletion and female methamphetamine abusers en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several lines of evidence suggest that increased generation of auto-oxidized dopamine (DA) o-quinone is associated with the neurotoxicity of methamphetamine (MAP) in the brain, and that, as a cellular defenses against DA-derived quinines, glutathione S-transferase (GST) detoxifies auto-oxidized DA o-quinone in the brain. Glutathione S-transferase M1 (GSTM1) of the mu-class of GSTs catalyzes reaction between glutathione and catecholamine o-quinones under physiological conditions. This study was undertaken to investigate the role of the GSTM1 gene deletion polymorphism in the neuropathology of MAP abuse. One hundred fifty-seven MAP abusers and 200 healthy comparison subjects were tested for a genetic polymorphism of GSTM1. The difference in the frequency of deletion (D)/nondeletion (N) alleles between the female abusers and female controls was close to statistical significance (P=0.071), although there was no statistical difference (P=0.651) between male abusers and male controls. Furthermore, the number of female abusers with deletion alleles was significantly (P=0.007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects. (C) 2003 Wiley-Liss, Inc. en-copyright= kn-copyright= en-aut-name=KoizumiHiroki en-aut-sei=Koizumi en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoKenji en-aut-sei=Hashimoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KumakiriChikara en-aut-sei=Kumakiri en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuEiji en-aut-sei=Shimizu en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekineYoshimoto en-aut-sei=Sekine en-aut-mei=Yoshimoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiNorio en-aut-sei=Ozaki en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=InadaToshiya en-aut-sei=Inada en-aut-mei=Toshiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaranoMutsuo en-aut-sei=Harano en-aut-mei=Mutsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KomiyamaTokutaro en-aut-sei=Komiyama en-aut-mei=Tokutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaMitsuhiko en-aut-sei=Yamada en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SoraIchiro en-aut-sei=Sora en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=UjikeHiroshi en-aut-sei=Ujike en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TakeiNori en-aut-sei=Takei en-aut-mei=Nori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IyoMasaomi en-aut-sei=Iyo en-aut-mei=Masaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Department of Psychiatry and Neurology, Hamamatsu University School of Medicine affil-num=6 en-affil= kn-affil=Department of Psychiatry, Fujita Health University School of Medicine affil-num=7 en-affil= kn-affil=Department of Psychiatry, Nagoya University Graduate School of Medicine affil-num=8 en-affil= kn-affil=Department of Neuropsychiatry, Kurume University School of Medicine affil-num=9 en-affil= kn-affil=National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry affil-num=10 en-affil= kn-affil=Karasuyama Hospital, Showa University School of Medicine affil-num=11 en-affil= kn-affil=Division of Psychobiology, Tohoku University Graduate School of Medicine affil-num=12 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry affil-num=13 en-affil= kn-affil=Department of Psychiatry and Neurology, Hamamatsu University School of Medicine affil-num=14 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine en-keyword=methamphetamine kn-keyword=methamphetamine en-keyword=drug abuse kn-keyword=drug abuse en-keyword=Glutathione S-transferase kn-keyword=Glutathione S-transferase en-keyword=gender difference kn-keyword=gender difference END start-ver=1.4 cd-journal=joma no-vol=203 cd-vols= no-issue=2 article-no= start-page=447 end-page=456 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Connective Tissue Growth Factor Causes Persistent Proƒ¿2(I) Collagen Gene Expression Induced by Transforming Growth Factor-ƒÀ in a Mouse Fibrosis Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Skin fibrotic disorders such as systemic sclerosis (SSc) are characterized by an excessive production of extracellular matrix (ECM) and understood to develop under the influence of certain growth factors. Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that is implicated in various fibrotic disorders and induced in fibroblasts after activation with transforming growth factor-beta (TGF-beta). To better understand the mechanisms of persistent fibrosis seen in SSc, we previously established an animal model of skin fibrosis induced by exogenous application of growth factors. In this model, TGF-beta transiently induced subcutaneous fibrosis and serial injections of CTGF after TGF-beta caused persistent fibrosis. To further define the mechanisms of skin fibrosis induced by TGF-beta and CTGF in vivo, we investigated in this study, the effects of growth factors on the promoter activity of the pro alpha 2 (1) collagen (COL1A2) gene in skin fibrosis. For this purpose, we utilized transgenic reporter mice harboring the -17 kb promoter sequence of the mouse COL1A2 linked to either a firefly luciferase gene or a bacterial P-galactosidase gene. Serial injections of CTGF after TGF-beta resulted in a sustained elevation of COL1A2 mRNA expression and promoter activity compared with consecutive injection of TGF-beta alone on day 8. We also demonstrated that the number of fibroblasts with activated COL1A2 transcription was increased by serial injections of CTGF after TGF-beta in comparison with the injection of TGF-beta alone. Furthermore, the serial injections recruited mast cells and macrophages. The number of mast cells reached a maximum on day 4 and remained relatively high up to day 8. In contrast to the kinetics of mast cells, the number of macrophages was increased on day 4 and continued to rise during the subsequent consecutive CTGF injections until day 8. These results suggested that CTGF maintains TGF-beta-induced skin fibrosis by sustaining COL1A2 promoter activation and increasing the number of activated fibroblasts. The infiltrated mast cells and macrophages may also contribute to the maintenance of fibrosis. en-copyright= kn-copyright= en-aut-name=ChujoSonoko en-aut-sei=Chujo en-aut-mei=Sonoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShirasakiFumiaki en-aut-sei=Shirasaki en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawaraShigeru en-aut-sei=Kawara en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InagakiYutaka en-aut-sei=Inagaki en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KinbaraTakuro en-aut-sei=Kinbara en-aut-mei=Takuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InaokiMakoto en-aut-sei=Inaoki en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakigawaMasaharu en-aut-sei=Takigawa en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeharaKazuhiko en-aut-sei=Takehara en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Dermatology, Kanazawa University Graduate School of Medical Science affil-num=2 en-affil= kn-affil=Department of Dermatology, Kanazawa University Graduate School of Medical Science affil-num=3 en-affil= kn-affil=Department of Dermatology, National Kanazawa Hospital affil-num=4 en-affil= kn-affil=Department of Community Health, Tokai University School of Medicine affil-num=5 en-affil= kn-affil=Department of Dermatology, Kanazawa University Graduate School of Medical Science affil-num=6 en-affil= kn-affil=Department of Dermatology, Kawasaki Medical School affil-num=7 en-affil= kn-affil=Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry affil-num=8 en-affil= kn-affil=Department of Dermatology, Kanazawa University Graduate School of Medical Science en-keyword=systemic sclerosis kn-keyword=systemic sclerosis en-keyword=fibrosis kn-keyword=fibrosis en-keyword=transforming growth factor-? kn-keyword=transforming growth factor-? en-keyword=connective tissue growth factor kn-keyword=connective tissue growth factor END start-ver=1.4 cd-journal=joma no-vol=38 cd-vols= no-issue=9 article-no= start-page=1751 end-page=1759 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flow-induced hardening of endothelial nucleus as an intracellular stress-bearing organelle en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mechanical contribution of nucleus in adherent cells to bearing intracellular stresses remains unclear. In this paper, the effects of fluid shear stress on morphology and elastic properties of endothelial nuclei were investigated. The morphological observation suggested that the nuclei in the cytoplasm were being vertically compressed under static conditions, whereas they were elongated and more compressed with a fluid shear stress of 2 Pa (20 dyn/cm(2)) onto the cell. The elongated nuclei remained the shape even after they were isolated from the cells. The micropipette aspiration technique on the isolated nuclei revealed that the elastic modulus of elongated nuclei, 0.62 +/- 0.15 kPa (n = 13, mean +/- SD), was significantly higher than that of control nuclei, 0.42 +/- 0.12 kPa (n = 11), suggesting that the nuclei remodeled their structure due to the shear stress. Based of these results and a transmission electron microscopy, a possibility of the nucleus as an intracellular compression-bearing organelle was proposed, which will impact interpretation of stress distribution in adherent cells. (C) 2005 Elsevier Ltd. All rights reserved. en-copyright= kn-copyright= en-aut-name=DeguchiShinji en-aut-sei=Deguchi en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaedaKenjiro en-aut-sei=Maeda en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhashiToshiro en-aut-sei=Ohashi en-aut-mei=Toshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoMasaaki en-aut-sei=Sato en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Energy Systems Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University affil-num=3 en-affil= kn-affil=Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University affil-num=4 en-affil= kn-affil=Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University en-keyword=cell mechanics kn-keyword=cell mechanics en-keyword=nucleus kn-keyword=nucleus en-keyword=mechanical properties kn-keyword=mechanical properties en-keyword=shear stress kn-keyword=shear stress en-keyword=mechanotransduction kn-keyword=mechanotransduction en-keyword=atomic-force microscopy kn-keyword=atomic-force microscopy en-keyword=shear-stress kn-keyword=shear-stress en-keyword=mechanical-properties kn-keyword=mechanical-properties en-keyword=viscoelastic kn-keyword=viscoelastic en-keyword=properties kn-keyword=properties en-keyword=cells kn-keyword=cells END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=1 article-no= start-page=49 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interpopulation variation in female remating is attributable to female and male effects in Callosobruchus chinensis en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The evolution of female multiple mating is best understood by consideration of male and female reproductive perspectives. Females should usually be selected to remate at their optimum frequencies whereas males should be selected to manipulate female remating to their advantage. Female remating behavior may therefore be changed by variation of male and female traits. In this study, our objective was to separate the effects of female and male strains on female remating for the adzuki bean beetle, Callosobruchus chinensis, for which there is interstrain variation in female remating frequency. We found that interstrain variation in female remating is primarily attributable to female traits, suggesting genetic variation in female receptivity to remating in C. chinensis. Some interstrain variation in female remating propensity was attributable to an interaction between female and male strains, however, with the males of some strains being good at inducing nonreceptivity in females from one high-remating strain whereas others were good at inducing copulation in nonvirgin females from the high-remating strain. There is, therefore, interstrain variation in male ability to deter females from remating and in male ability to mate successfully with nonvirgin females. These results suggest that mating traits have evolved along different trajectories in different strains of C. chinensis.

en-copyright= kn-copyright= en-aut-name=HaranoTomohiro en-aut-sei=Harano en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyatakeTakahisa en-aut-sei=Miyatake en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and life Science, Okayama University kn-affil= en-keyword=polyandry kn-keyword=polyandry en-keyword=multiple mating kn-keyword=multiple mating en-keyword=sexual conflict kn-keyword=sexual conflict en-keyword=sexual selection kn-keyword=sexual selection en-keyword=genetic variation kn-keyword=genetic variation en-keyword=Callosobruchus chinensis kn-keyword=Callosobruchus chinensis END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=16 article-no= start-page=3133 end-page=3141 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19988 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The ich1 gene of the mushroom Coprinus cinereus is essential for pileus formation in fruiting en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The formation of the pileus in homobasidiomycete fungi is essential for sexual reproduction, because the pileus bears the hymenium, a layer of cells that includes the specialised basidia in which nuclear fusion, meiosis and sporulation occur. The developmental mutant ichijiku of Coprinus cinereus fails to develop a differentiated pileus at the apex of the primordial shaft, which is the basal part of the fruit-body primordia and formed in an early stage of fruit-body differentiation. Genetic analysis indicates that this phenotype is caused by a recessive mutation in a single gene (ich1). The ich1 gene was mapped to chromosome XII using restriction fragment length polymorphism markers and the marker chromosome method, and cloned by complementation using a chromosome-XII-specific cosmid library. The ich1 gene encodes a novel protein of 1,353 amino acids. The Ich1 amino-acid sequence contains nuclear targeting signals, suggesting that the Ich1 protein would function in the nucleus. Northern blot analysis indicates that the ich1 gene is specifically expressed in the pileus of the wild-type fruit-body. No ich1 mRNA was detected in the ichijiku mutant, consistent with loss of the promoter region of ich1 in the mutant genome. These data demonstrate that the ick1 gene product is essential for pileus formation.

en-copyright= kn-copyright= en-aut-name=MuraguchiHajime en-aut-sei=Muraguchi en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KamadaTakashi en-aut-sei=Kamada en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=Developmental mutant kn-keyword=Developmental mutant en-keyword=Ich1 kn-keyword=Ich1 en-keyword=Pileus kn-keyword=Pileus en-keyword=Fruit-body kn-keyword=Fruit-body en-keyword=morphogenesis kn-keyword=morphogenesis en-keyword=Basidiomycete kn-keyword=Basidiomycete en-keyword=Coprinus kn-keyword=Coprinus END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=3 article-no= start-page=255 end-page=261 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ownership-dependent mating tactics of minor males of the beetle Librodor japonicus (Nitidulidae) with intra-sexual dimorphism of mandibles en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Intra-sexual dimorphism is found in the weapons of many male beetles. Different behavioral tactics to access females between major and minor males, which adopt fighting and alternative tactics, respectively, are thought to maintain the male dimorphism. In these species major males have enlarged weapons that they use in fights with rival males. Minor males also have small weapons in some of these species, and it is unclear why these males possess weapons. We examined the hypothesis that minor males might adopt a fighting tactic when their status was relatively high in comparison with that of other males (e.g., ownership of a territory). We observed the behavioral tactics of major and minor males of the beetle Librodor japonicus, whose males have a dimorphism of their mandibles. Major males fought for resources, whereas minor males adopted two status-dependent tactics, fighting and sneaking, to access females, depending on their ownership of a sap site. We suggest that ownership status-dependent mating tactics in minor males may maintain the intra-sexual dimorphism in this beetle.

en-copyright= kn-copyright= en-aut-name=OkadaKensuke en-aut-sei=Okada en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyatakeTakahisa en-aut-sei=Miyatake en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil= en-keyword=allometry kn-keyword=allometry en-keyword=alternative phenotype kn-keyword=alternative phenotype en-keyword=exaggerated trait kn-keyword=exaggerated trait en-keyword=male competition kn-keyword=male competition en-keyword=status-dependent selection kn-keyword=status-dependent selection END start-ver=1.4 cd-journal=joma no-vol=135B cd-vols= no-issue=1 article-no= start-page=5 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050505 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile 105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population. en-copyright= kn-copyright= en-aut-name=HashimotoTasuku en-aut-sei=Hashimoto en-aut-mei=Tasuku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoKenji en-aut-sei=Hashimoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuzakaDaisuke en-aut-sei=Matsuzaka en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuEiji en-aut-sei=Shimizu en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekineYoshimoto en-aut-sei=Sekine en-aut-mei=Yoshimoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshiyaInada en-aut-sei=Yoshiya en-aut-mei=Inada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IwataNakao en-aut-sei=Iwata en-aut-mei=Nakao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaranoMutsuo en-aut-sei=Harano en-aut-mei=Mutsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KomiyamaTokutaro en-aut-sei=Komiyama en-aut-mei=Tokutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaMitsuhiko en-aut-sei=Yamada en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SoraIchiro en-aut-sei=Sora en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=UjikeHiroshi en-aut-sei=Ujike en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IyoMasaomi en-aut-sei=Iyo en-aut-mei=Masaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Department of Psychiatry and Neurology, Hamamatsu University School of Medicine affil-num=6 en-affil= kn-affil=Department of Psychiatry, Nagoya University Graduate School of Medicine affil-num=7 en-affil= kn-affil=Department of Psychiatry, Fujita Health University School of Medicine affil-num=8 en-affil= kn-affil=Department of Neuropsychiatry, Kurume University School of Medicine affil-num=9 en-affil= kn-affil=National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP) affil-num=10 en-affil= kn-affil=National Institute of Mental Health, NCNP affil-num=11 en-affil= kn-affil=Division of Psychobiology, Tohoku University Graduate School of Medicine affil-num=12 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry affil-num=13 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine en-keyword=methamphetamine kn-keyword=methamphetamine en-keyword=psychosis kn-keyword=psychosis en-keyword=drug abuse kn-keyword=drug abuse en-keyword=genetic factor; polymorphism kn-keyword=genetic factor; polymorphism END start-ver=1.4 cd-journal=joma no-vol=271 cd-vols= no-issue=1 article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure and expression of 12-oxophytodienoate reductase (OPR) subgroup I gene in pea and oxidoreductase activity of their recombinant proteins en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Recently, we observed that expression of a pea gene (S64) encoding an oxophytodienoic acid reductase (OPR) was induced by a suppressor of pea defense responses, secreted by the pea pathogen Mycosphaerella pinodes. Because it is known that OPRs are usually encoded by families of homologous genes, we screened for genomic and cDNA clones encoding members of this putative OPR family in pea. We isolated five members of the OPR gene family from a pea genomic DNA library, and amplified six cDNA clones, including S64, by RT-PCR (reverse transcriptase-PCR). Sequencing analysis revealed that S64 corresponds to PsOPR2, and the amino acid sequences of the predicted products of the six OPR-like genes shared more than 80% identity with each other. Based on their sequence similarity, all these OPR-like genes code for OPRs of subgroup I, i.e., enzymes which are not required for jasmonic acid biosynthesis. However, the genes varied in their exon/intron organization and in their promoter sequences. To investigate the expression of each individual OPR-like gene, RT-PCR was performed using gene-specific primers. The results indicated that the OPR-like gene most strongly induced by the inoculation of pea plants with a compatible pathogen and by treatment with the suppressor from M. pinodes was PsOPR2. Furthermore, the ability of the six recombinant OPR-like proteins to reduce a model substrate, 2-cyclohexen-1-one (2-CyHE), was investigated. The results indicated that PsOPR1, 4 and 6 display robust activity, and PsOPR2 has a most remarkable ability to reduce 2-CyHE, whereas PsOPR3 has little and PsOPR5 does not reduce this compound. Thus, the six OPR-like proteins can be classified into four types. Interestingly, the gene structures, expression profiles, and enzymatic activities used to classify each member of the pea OPR-like gene family are clearly correlated, indicating that each member of this OPR-like family has a distinct function.

en-copyright= kn-copyright= en-aut-name=MatsuiH en-aut-sei=Matsui en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraG en-aut-sei=Nakamura en-aut-mei=G kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshigaY en-aut-sei=Ishiga en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToshimaH en-aut-sei=Toshima en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InagakiY en-aut-sei=Inagaki en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyodaK en-aut-sei=Toyoda en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiraishiT en-aut-sei=Shiraishi en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=4 en-affil= kn-affil=Ibaraki University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=6 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=7 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University affil-num=8 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Faculty of Agriculture, Okayama University en-keyword=coronatine kn-keyword=coronatine en-keyword=flavoproteins kn-keyword=flavoproteins en-keyword=Jasmonic acid kn-keyword=Jasmonic acid en-keyword=oxophytodienoic acid reductase kn-keyword=oxophytodienoic acid reductase en-keyword=OPR kn-keyword=OPR en-keyword=suppressor kn-keyword=suppressor END start-ver=1.4 cd-journal=joma no-vol=132B cd-vols= no-issue=1 article-no= start-page=70 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C>T (C270T named formerly) in the noncoding region of exon V and 196G >A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C>T in exon V: genotype, p = 0.586, allele, p = 0.594; 196G>A (val66met) in exon XIIIA: genotype, p = 0.889, allele, p = 0.713). Furthermore, there was no difference between clinical parameters (e.g. prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C>T in exon V and 196G>A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers. en-copyright= kn-copyright= en-aut-name=ItohKanako en-aut-sei=Itoh en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoKenji en-aut-sei=Hashimoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimizuEiji en-aut-sei=Shimizu en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SekineYoshimoto en-aut-sei=Sekine en-aut-mei=Yoshimoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OzakiNorio en-aut-sei=Ozaki en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InadaToshiya en-aut-sei=Inada en-aut-mei=Toshiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HaranoMutsuo en-aut-sei=Harano en-aut-mei=Mutsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IwataNakao en-aut-sei=Iwata en-aut-mei=Nakao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KomiyamaTokutaro en-aut-sei=Komiyama en-aut-mei=Tokutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaMitsuhiko en-aut-sei=Yamada en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SoraIchiro en-aut-sei=Sora en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakataKenji en-aut-sei=Nakata en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=UjikeHiroshi en-aut-sei=Ujike en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IyoMasaomi en-aut-sei=Iyo en-aut-mei=Masaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Psychiatry and Neurology, Hamamatsu University School of Medicine affil-num=5 en-affil= kn-affil=Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine affil-num=6 en-affil= kn-affil=Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine affil-num=7 en-affil= kn-affil=Department of Neuropsychiatry, Kurume University School of Medicine affil-num=8 en-affil= kn-affil=Department of Psychiatry, Fujita Health University School of Medicine affil-num=9 en-affil= kn-affil=National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry affil-num=10 en-affil= kn-affil=Karasuyama Hospital, Showa University School of Medicine affil-num=11 en-affil= kn-affil=Division of Psychobiology, Tohoku University Graduate School of Medicine affil-num=12 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry affil-num=13 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry affil-num=14 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine en-keyword=brain-derived neurotrophic factor kn-keyword=brain-derived neurotrophic factor en-keyword=polymorphism kn-keyword=polymorphism en-keyword=drug abuse kn-keyword=drug abuse en-keyword=methamphetamine kn-keyword=methamphetamine END start-ver=1.4 cd-journal=joma no-vol=207 cd-vols= no-issue=4 article-no= start-page=621 end-page=632 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20042 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Purification and cDNA cloning of the ovigerous-hair stripping substance (OHSS) contained in the hatch water of an estuarine crab Sesarma haematocheir en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The egg attachment system of an estuarine crab Sesarma haematocheir is formed on the maternal ovigerous hairs just after egg laying, and slips off these hairs just after hatching. The stripping is caused by an active factor that we call OHSS (ovigerous-hair stripping substance), which is released by the embryo upon hatching. OHSS was purified, and its active form had a molecular mass of 25?kDa. The cDNA of OHSS cloned from an embryonic cDNA library was 1759?bp long, encoding 492 amino acids in a single open reading frame (ORF). The C-terminal part of the predicted protein was composed of a trypsin-like serine protease domain, with homology to counterparts in other animals of 33?38%. The predicted protein (54.7?kDa) secreted as a zymogen may be cleaved post-translationally, separating the Cterminal from the N-terminal region. The OHSS gene was expressed in the embryo at least 2 weeks before hatching. Expression was also detected in the zoea larva 1 day after hatching and in the brain of the female. However, it was not detected in the muscle, hepatopancreas or ovigerous seta of the female. Ultrastructural analysis indicated that the material investing maternal ovigerous hair, i.e. the outermost layer (E1) of the egg case, is attached at the special sites (attachment sites) arranged at intervals of 130?160?nm on the hair. It is suggested that OHSS acts specifically at these sites, lysing the bond with the coat, thus disposing of the embryo attachment system. This enables the female to prepare the next clutch of embryos without ecdysis.

en-copyright= kn-copyright= en-aut-name=GusevOleg en-aut-sei=Gusev en-aut-mei=Oleg kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaHideki en-aut-sei=Ikeda en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkochiTetsushi en-aut-sei=Okochi en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LeeJae Min en-aut-sei=Lee en-aut-mei=Jae Min kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HatakeyamaMasatsugu en-aut-sei=Hatakeyama en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KobayashiChiyoko en-aut-sei=Kobayashi en-aut-mei=Chiyoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AgataKiyokazu en-aut-sei=Agata en-aut-mei=Kiyokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamadaHidenori en-aut-sei=Yamada en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SaigusaMasayuki en-aut-sei=Saigusa en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=5 en-affil= kn-affil=National Institute of Agrobiological Sciences, Owashi affil-num=6 en-affil= kn-affil=RIKEN, Hyougo affil-num=7 en-affil= kn-affil=RIKEN, Hyougo affil-num=8 en-affil= kn-affil=Okayama Univresity affil-num=9 en-affil= kn-affil=Okayama University en-keyword=crab kn-keyword=crab en-keyword=Sesarma (or Chiromantes) haematocheir kn-keyword=Sesarma (or Chiromantes) haematocheir en-keyword=ovigerous hair kn-keyword=ovigerous hair en-keyword=embryo attachment system kn-keyword=embryo attachment system en-keyword=investment coat kn-keyword=investment coat en-keyword=stripping kn-keyword=stripping en-keyword= ovigerous-hair stripping substance (OHSS) kn-keyword= ovigerous-hair stripping substance (OHSS) en-keyword= serine protease. kn-keyword= serine protease. END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=6 article-no= start-page=923 end-page=938 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20066 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Identification of glycosylation genes and glycosylated amino acids of flagellin in Pseudomonas syringae pv. tabaci en-subtitle= kn-subtitle= en-abstract= kn-abstract=A glycosylation island is a genetic region required for glycosylation. The glycosylation island of flagellin in Pseudomonas syringae pv. tabaci 6605 consists of three orfs: orf1, orf2 and orf3. Orf1 and orf2 encode putative glycosyltransferases, and their deletion mutants, Delta orf1 and Delta orf2, exhibit deficient flagellin glycosylation or produce partially glycosylated flagellin respectively. Digestion of glycosylated flagellin from wild-type bacteria and non-glycosylated flagellin from Delta orf1 mutant using aspartic N-peptidase and subsequent HPLC analysis revealed candidate glycosylated amino acids. By generation of site-directed Ser/Ala-substituted mutants, all glycosylated amino acid residues were identified at positions 143, 164, 176, 183, 193 and 201. Matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry (MS) analysis revealed that each glycan was about 540 Da. While all glycosylation-defective mutants retained swimming ability, swarming ability was reduced in the Delta orf1, Delta orf2 and Ser/Ala-substituted mutants. All glycosylation mutants were also found to be impaired in the ability to adhere to a polystyrene surface and in the ability to cause disease in tobacco. Based on the predicted tertiary structure of flagellin, S176 and S183 are expected to be located on most external surface of the flagellum. Thus the effect of Ala-substitution of these serines is stronger than that of other serines. These results suggest that glycosylation of flagellin in P. syringae pv. tabaci 6605 is required for bacterial virulence. It is also possible that glycosylation of flagellin may mask elicitor function of flagellin molecule. en-copyright= kn-copyright= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakeuchiKasumi en-aut-sei=Takeuchi en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KatohEtsuko en-aut-sei=Katoh en-aut-mei=Etsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurataKatsuyoshi en-aut-sei=Murata en-aut-mei=Katsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SuzukiTomoko en-aut-sei=Suzuki en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MarutaniMizuri en-aut-sei=Marutani en-aut-mei=Mizuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawasakiTakayuki en-aut-sei=Kawasaki en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EguchiMinako en-aut-sei=Eguchi en-aut-mei=Minako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatohShizue en-aut-sei=Katoh en-aut-mei=Shizue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=kakuHanae en-aut-sei=kaku en-aut-mei=Hanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YasudaChihiro en-aut-sei=Yasuda en-aut-mei=Chihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=InagakiYoshishige en-aut-sei=Inagaki en-aut-mei=Yoshishige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=4 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=9 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=10 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=11 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=12 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=13 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=14 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=15 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University en-keyword=Gram-Negative bacteria kn-keyword=Gram-Negative bacteria en-keyword=Posttranslational modification kn-keyword=Posttranslational modification en-keyword=Protein Glycosylation kn-keyword=Protein Glycosylation en-keyword=Perception kn-keyword=Perception en-keyword=Aeruginosa kn-keyword=Aeruginosa en-keyword=Cells kn-keyword=Cells en-keyword=Specificity kn-keyword=Specificity en-keyword=Expression kn-keyword=Expression en-keyword=Plasmids kn-keyword=Plasmids en-keyword=Pathways kn-keyword=Pathways END start-ver=1.4 cd-journal=joma no-vol=200 cd-vols= no-issue=20 article-no= start-page=2583 end-page=2595 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Three neural groups in the femoral chordotonal organ of the cricket Gryllus bimaculatus: Central projections and soma arrangement and displacement during joint flexion en-subtitle= kn-subtitle= en-abstract= kn-abstract=The arrangement of neuronal somata and their displacement during joint flexion together with the central projection of the pro- and metathoracic femoral chordotonal organs (FCOs) in the cricket were investigated. The FCO consists of the partially fused ventral and dorsal scoloparia in the proximal femur. The ventrally located neurones (the ventral group) form chainlike rows in which somata became sequentially smallerdistally and project their axons ipsilaterally to the dorsolateral regions, giving off abundant branches and terminating in the region between the dorsal intermediatetract and the ventral intermediate tract in the thoracichemiganglion. The dorsal scoloparium, composed of small,simply aggregated neurones, projects exclusively to the medioventral association centre (mVAC), which is known to be an auditory neuropile. In addition, another neural cluster (the dorsal group) was found in the proximo-dorsal region of the ventral scoloparium. This was composed of simply aggregated neurones with axons giving off sparse branches dorso-laterally and terminating in the peripheral region inside the mVAC. The somata of these three groups were displaced distally by flexion of the femoro-tibial joint: the ventral group showed the greatest displacement, with the degree of movement depending upon soma location, while the dorsal group and dorsal scoloparium neurones were hardly displaced, possibly because of their strong connection with the cuticle. These properties were similar in both the prothoracic FCO and the metathoracic FCO. Taken together, the above points suggest that there is greater functional differentiation of the FCO than was previously thought. en-copyright= kn-copyright= en-aut-name=NishinoHiroshi en-aut-sei=Nishino en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakaiMasaki en-aut-sei=Sakai en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Neuro-Cybernetics, Research Institute for Electronic Science, Hokkaido University affil-num=2 en-affil= kn-affil=Department of Biology, Faculty of Science, Okayama University en-keyword=Gryllus bimaculatus kn-keyword=Gryllus bimaculatus en-keyword=femoral chordotonal organ kn-keyword=femoral chordotonal organ en-keyword=neural grouping kn-keyword=neural grouping en-keyword=connective tissues kn-keyword=connective tissues en-keyword=soma displacement kn-keyword=soma displacement en-keyword=central kn-keyword=central en-keyword=projection. kn-keyword=projection. END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=14 article-no= start-page=1929 end-page=1940 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19987 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Initiation of skin basement membrane formation at the epidermo-dermal interface involves assembly of laminins through binding to cell membrane receptors en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To study the mechanism of basement membrane formation, we determined by immunochemistry temporal and spatial expression of laminin-5 (Ln-5), laminin-1 (Ln-1) and their integrin receptors during early skin morphogenesis. A 3-dimensional skin culture was used that allows the study of the sequential molecular events of basement membrane formation at the epidermodermal interface. During early anchorage of keratinocytes to the extracellular matrix there is expression of Ln-5, BP-230 antigen and α3, β1 integrin subunits. During epidermal stratification and prior to the formation of the lamina densa there is assembly of Ln-5, Ln-1, collagen IV and nidogen accompanied by keratinocyte basal clustering of α2, α3, α6, β1, and β4 integrin subunits. The assembly pattern of Ln-1 and Ln-5 can be disturbed with functional antibodies against the β1 (AIIB2) and α6 (GoH3) integrin subunits. Ln-1 assembly can also be disturbed with antibodies against its E8 domain and by competitive inhibition with a synthetic peptide (AG-73) derived from its G-4 domain. Quantitative RT-PCR showed that the dermis contributes about 80% of the laminin γ1 chain mRNA while 20% is produced by the epidermis which emphasizes its dual tissue origin and the major contribution of the mesenchyma in laminin production. The laminin γ2 chain mRNA, present in Ln-5, was mostly of epidermal origin. This study presents evidence that during the initiation of basement membrane formation, laminins bind to keratinocyte plasma membrane receptors and thus may serve as nucleation sites for further polymerization of these compounds by a self-assembly process.

en-copyright= kn-copyright= en-aut-name=FleischmajerRaul en-aut-sei=Fleischmajer en-aut-mei=Raul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UtaniAtsushi en-aut-sei=Utani en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Douglas MacDonald IIE. en-aut-sei=Douglas MacDonald II en-aut-mei=E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=PerlishJerome S en-aut-sei=Perlish en-aut-mei=Jerome S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=PanTe-Cheng en-aut-sei=Pan en-aut-mei=Te-Cheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ChuMon-Li en-aut-sei=Chu en-aut-mei=Mon-Li kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NomizuMotoyoshi en-aut-sei=Nomizu en-aut-mei=Motoyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NinomiyaYoshifumi en-aut-sei=Ninomiya en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamadaYoshihiko en-aut-sei=Yamada en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Mount Sinai School of Medicine, New York affil-num=2 en-affil= kn-affil=National Institute of Dental Research, National Institutes of Health affil-num=3 en-affil= kn-affil=Mount Sinai School of Medicine, New York affil-num=4 en-affil= kn-affil=Mount Sinai School of Medicine, New York affil-num=5 en-affil= kn-affil=Thomas Jefferson University affil-num=6 en-affil= kn-affil=Thomas Jefferson University affil-num=7 en-affil= kn-affil=National Institute of Dental Research, National Institutes of Health affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=National Institute of Dental Research, National Institutes of Health en-keyword=Basement membrane kn-keyword=Basement membrane en-keyword=Laminin kn-keyword=Laminin en-keyword=Integrin kn-keyword=Integrin END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=18 article-no= start-page=3575 end-page=3585 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060915 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The dwarf phenotype of the Arabidopsis acl5 mutant is suppressed by a mutation in an upstream ORF of a bHLH gene en-subtitle= kn-subtitle= en-abstract= kn-abstract=Loss-of-function mutants of the Arabidopsis thaliana ACAULIS 5 (ACL5) gene, which encodes spermine synthase, exhibit a severe dwarf phenotype. To elucidate the ACL5-mediated regulatory pathways of stem internocle elongation, we isolated four suppressor of acaulis (sac) mutants that reverse the acl5 dwarf phenotype. Because these mutants do not rescue the dwarfism of known phytohormone-related mutants, the SAC genes appear to act specifically on the ACL5 pathways. We identify the gene responsible for the dominant sac51-d mutant, which almost completely suppresses the acl5 phenotype. sac51-d disrupts a short upstream open reading frame (uORF) of SAC51, which encodes a bHLH-type transcription factor. Our results indicate that premature termination of the uORF in sac51-d results in an increase in its own transcript level, probably as a result of an increased translation of the main ORF. We suggest a model in which ACL5 plays a role in the translational activation of SAC51, which may lead to the expression of a subset of genes required for stem elongation. en-copyright= kn-copyright= en-aut-name=ImaiAkihiro en-aut-sei=Imai en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanzawaYoshie en-aut-sei=Hanzawa en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomuraMio en-aut-sei=Komura en-aut-mei=Mio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoKotaro T. en-aut-sei=Yamamoto en-aut-mei=Kotaro T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomedaYoshibumi en-aut-sei=Komeda en-aut-mei=Yoshibumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiTaku en-aut-sei=Takahashi en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Division of Biological Sciences, Graduate School of Science, Hokkaido University affil-num=3 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Biological Sciences, Graduate School of Science, Hokkaido University affil-num=5 en-affil= kn-affil=Division of Biological Sciences, Graduate School of Science, Hokkaido University affil-num=6 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University en-keyword=Arabidopsis thaliana kn-keyword=Arabidopsis thaliana en-keyword=Polyamine kn-keyword=Polyamine en-keyword=Spermine kn-keyword=Spermine en-keyword=Stem elongation kn-keyword=Stem elongation en-keyword=Upstream ORF kn-keyword=Upstream ORF END start-ver=1.4 cd-journal=joma no-vol=224 cd-vols= no-issue=2 article-no= start-page=311 end-page=319 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050628 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract=About 97% of synovial sarcomas harbor the SYT-SSX fusion gene by chromosomal translocation. We found that the histone deacetylase (HDAC) inhibitor FK228 significantly suppressed the growth of synovial sarcoma cells as compared with that of osteosarcoma. The 50% growth inhibition IC50 value we obtained for FK228 was 0.02-0.2 nM, and it indicates that its suppression effect on synovial sarcoma cells is the highest of any of the HDAC inhibitors yet reported. It was not likely that the growth suppression of FK228 depends on the doubling time of these cells. Introduction of SYT-SSX cDNA into HEK293 cells enhanced the sensitivity of the cells for FK228. Immunostaining of the FK228-treated cells using an anti-acetyl-histone H3 antibody showed that FK228 inhibits deacetylation of histone. In a mice assay, the growth of synovial sarcoma cells was markedly inhibited by FK228 treatment, and the invasion of tumors into surrounding tissues was suppressed. These results suggest that FK228 may be useful in developing therapeutic strategies to treat synovial sarcoma. en-copyright= kn-copyright= en-aut-name=ItoTatsuo en-aut-sei=Ito en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OuchidaMamoru en-aut-sei=Ouchida en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimotoYuki en-aut-sei=Morimoto en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshidaAki en-aut-sei=Yoshida en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=JitsumoriYoshimi en-aut-sei=Jitsumori en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShimizuKenji en-aut-sei=Shimizu en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine and Dentistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University affil-num=3 en-affil= kn-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine and Dentistry, Okayama University affil-num=4 en-affil= kn-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine and Dentistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University affil-num=6 en-affil= kn-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine and Dentistry, Okayama University affil-num=7 en-affil= kn-affil=Department of Laboratory Medicine and Pathology, National Fukuyama Hospital affil-num=8 en-affil= kn-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine and Dentistry, Okayama University affil-num=9 en-affil= kn-affil=Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University en-keyword=histone deacetylase inhibitor kn-keyword=histone deacetylase inhibitor en-keyword=synovial sarcoma kn-keyword=synovial sarcoma en-keyword=growth inhibition kn-keyword=growth inhibition en-keyword=in vivo kn-keyword=in vivo END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=9 article-no= start-page=1913 end-page=1915 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080515 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=CO oxidation on perovskite-type LaCoO3 synthesized using ethylene glycol and citric acid en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to synthesize perovskite-type LaCoO3 with good surface crystallinity, the gel prepared by adding both ethylene glycol (EG) and citric acid (CA) to the aqueous solution of La(NO3)3 center dot 6H(2)O and Co(NO3)(2) center dot 6H(2)O was fired at 600 degrees C in air for 3 h. The transmission electron microscopy (TEM) observation indicated that the particles of LaCoO3 tended to have a uniform shape at EG/CA = 4. Although, the specific surface area of LaCoO3 synthesized using both EG and CA was slightly smaller than that of LaCoO3 synthesized using only CA, the catalytic activity of CO oxidation became higher by adding EG. en-copyright= kn-copyright= en-aut-name=TaguchiHideki en-aut-sei=Taguchi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamasakiSatoshi en-aut-sei=Yamasaki en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItadaniAtsushi en-aut-sei=Itadani en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YosinagaMasashi en-aut-sei=Yosinaga en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirotaKen en-aut-sei=Hirota en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology (Science), Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology (Science), Okayama University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology (Science), Okayama University affil-num=4 en-affil= kn-affil=Kyoto Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, JST affil-num=5 en-affil= kn-affil=Faculty of Engineering, Doshisha University en-keyword=LaCoO3 kn-keyword=LaCoO3 en-keyword=perovskite kn-keyword=perovskite en-keyword=sol-gel preparation kn-keyword=sol-gel preparation en-keyword=CO oxidation kn-keyword=CO oxidation END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=8 article-no= start-page=1134 end-page=1139 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20058 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intermolecular-medium and intramolecular-weak hydrogen bonding chains in the crystals of chiral trifluoromethylated amino alcohols en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A structural feature of hydrogen bonding chains found in the crystals of trifluoromethylated amino alcohols is reported. Hydrogen bondings of 3-(N,N-dialkylamino)-1,1,1-trifluoro-2-propanols construct chiral spiral hydrogen bonding chains. Lone pairs on the nitrogen atoms of the amino alcohols participate in two hydrogen bondings. Detailed structural analysis of the hydrogen bonds of the 3-(N,N-dimethylamino)-1,1,1-trifluoro-2-propanol suggested that the chain built up with alternating intermolecular medium and intramolecular weak hydrogen bonds. The medium intermolecular hydrogen bond, which transfers a proton from the hydroxy group to the amino nitrogen, would make a tentative zwitterionic form of the molecule. Then, electrostatic attraction between the charges in the zwitterion centers induced a weak intramolecular hydrogen bond.

en-copyright= kn-copyright= en-aut-name=KatagiriToshimasa en-aut-sei=Katagiri en-aut-mei=Toshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiwaraYasuyuki en-aut-sei=Fujiwara en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiSatoshi en-aut-sei=Takahashi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UneyamaKenji en-aut-sei=Uneyama en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=hydrogen bond kn-keyword=hydrogen bond en-keyword=weak hydrogen bond kn-keyword=weak hydrogen bond en-keyword=medium hydrogen bond kn-keyword=medium hydrogen bond en-keyword=hydrogen bonding chain kn-keyword=hydrogen bonding chain en-keyword=trifluoromethylated amino alcohols kn-keyword=trifluoromethylated amino alcohols en-keyword=chiral recognition kn-keyword=chiral recognition en-keyword=structure of hydrogen bond kn-keyword=structure of hydrogen bond END start-ver=1.4 cd-journal=joma no-vol=162 cd-vols= no-issue=1 article-no= start-page=73 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20042 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Separation into polar and hydrogen-bonding factors of the effects of alcohols on the emission spectrum of 4-phenyl-1-N,N-dimethylaminobutane in THF en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The effects of the additions of protic and aprotic polar solvents on the emission spectrum of 4-phenyl-1-N,N-dimethylaminobutane (PDAB) in THF have been studied under conditions of steady-state illumination. The fluorescence spectrum of PDAB in THF was reported to consist of three component bands (band A at 285 nm (fluorescence of the phenyl group), band B at 343 nm (fluorescence of the amino group) and band C at 385 nm (emission from an intramolecular exciplex)). The intensities of bands B and C decreased with increasing solvent polarity. They also decreased owing to the hydrogen-bonding interaction between the amino group in PDAB and protic solvents, but in this case the intensity of band A was found to increase. Acetonitrile has only a polar effect and trichloroacetic acid only a hydrogen-bonding (or protonation) effect, while alcohols have both effects. The equilibrium constants for the formation of intermolecular hydrogen-bonded complexes of the amino group with alcohols were estimated from the intensity change of band A. The hydrogen-bonding and polar effects of alcohols on the intensities of bands B and C could be separately evaluated. The decrease in the intensities of bands B and C with increasing solvent polarity in THF-AN and THF-alcohol mixtures is considered to be caused by the conversion of the exciplex to an ion-pair enhanced by the increase in solvent polarity.

en-copyright= kn-copyright= en-aut-name=GuobinXie en-aut-sei=Guobin en-aut-mei=Xie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraMayuko en-aut-sei=Nakamura en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SueishiYoshimi en-aut-sei=Sueishi en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoShunzo en-aut-sei=Yamamoto en-aut-mei=Shunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univresity affil-num=4 en-affil= kn-affil=Okayama University en-keyword=solvent effect kn-keyword=solvent effect en-keyword=polar effect kn-keyword=polar effect en-keyword=hydrogen-bonding kn-keyword=hydrogen-bonding en-keyword=fluorescence kn-keyword=fluorescence en-keyword=exciplex kn-keyword=exciplex END start-ver=1.4 cd-journal=joma no-vol=162 cd-vols= no-issue=2-3 article-no= start-page=449 end-page=456 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20043 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of alcohols on emission spectra of toluene-triethylamine mixtures in THF: separation into polar and hydrogen-bonding interactions en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The emission spectra of toluene (T)?triethylamine (TEA) systems were measured under conditions of steady-state illumination in some protic and aprotic solvent?THF mixtures. The fluorescence spectrum of the T?TEA system in THF could be separated into three component bands (band A at 279 nm (fluorescence of T), band B at 336 nm (fluorescence of TEA) and band C at 373 nm (emission from an intermolecular exciplex)). The intensities of bands B and C decreased with increasing solvent polarity. The decrease in the intensities of bands B and C is considered to be caused by the enhanced conversion of the exciplex to an ion-pair with increase in solvent polarity. The intensities of bands B and C also decreased owing to the hydrogen-bonding interaction between TEA and protic solvents, but in this case the intensity of band A increased. Acetonitrile only has a polar effect and trichloroacetic acid only has a hydrogen-bonding (or protonation) effect, while alcohols have both effects. The equilibrium constants for the formation of intermolecular hydrogen-bonded complexes of TEA with alcohols were estimated from the changes in the intensity of band A. The hydrogen-bonding and polar effects of alcohols on the intensities of bands B and C could be evaluated separately. The ratio of the hydrogen-bonding effect to the polar effect of alcohols was observed to increase with increasing vol.% of alcohol.

en-copyright= kn-copyright= en-aut-name=XieGuobin en-aut-sei=Xie en-aut-mei=Guobin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SueishiYoshimi en-aut-sei=Sueishi en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamotoShunzo en-aut-sei=Yamamoto en-aut-mei=Shunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=solvent effect kn-keyword=solvent effect en-keyword=polar effect kn-keyword=polar effect en-keyword=hydrogen-bonding kn-keyword=hydrogen-bonding en-keyword=fluorescence kn-keyword=fluorescence en-keyword=exciplex kn-keyword=exciplex END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=8 article-no= start-page=1783 end-page=1792 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Condensation of 4-hydroxy-2-thiazolines with 1,2-phenylenediamine as a novel effective route to thiazolo[3,4-a]quinoxalines en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thiazolo[3,4-a]quinoxalin-4-ones were prepared in two steps starting from methyl phenylchloropyruvate using a new strategy for the construction of the ring system. A key step in this new method involves the reaction of 4-hydroxytetrahydrothiazoles with 1,2-phenylendiamines. en-copyright= kn-copyright= en-aut-name=MamedovVakhid A. en-aut-sei=Mamedov en-aut-mei=Vakhid A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NurkhametovaIlsiyar Z en-aut-sei=Nurkhametova en-aut-mei=Ilsiyar Z kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GubaidullinAidar T en-aut-sei=Gubaidullin en-aut-mei=Aidar T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LitvinovIgor A en-aut-sei=Litvinov en-aut-mei=Igor A kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsuboiSadao en-aut-sei=Tsuboi en-aut-mei=Sadao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Russian Academy of Sciences affil-num=2 en-affil= kn-affil=Russian Academy of Sciences affil-num=3 en-affil= kn-affil=Russian Academy of Sciences affil-num=4 en-affil= kn-affil=Russian Academy of Sciences affil-num=5 en-affil= kn-affil=Okayama University en-keyword=chlorophenylpyruvate kn-keyword=chlorophenylpyruvate en-keyword=thiazoline kn-keyword=thiazoline en-keyword=thiazole kn-keyword=thiazole en-keyword=alpha-halo ketone kn-keyword=alpha-halo ketone en-keyword=1 kn-keyword=1 en-keyword=2-phenylenediamine kn-keyword=2-phenylenediamine en-keyword=NITROGEN kn-keyword=NITROGEN END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=7 article-no= start-page=1005 end-page=1014 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080624 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Kinetic study of the reaction of leuco methylene blue with 2,6-dimethyl-p-benzoquinone in a reverse micellar system en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The kinetics of the reaction of leuco methylene blue (MBH) with 2,6-dimethyl-p-benzoquinone (DMBQ) were studied in a heptane/bis(2-ethylhexyl)-sulfosuccinate (AOT)/water reverse micellar system. The pseudo-first-order rate constant (k (obsd)) obtained in the presence of excess of DMBQ was found to be proportional to the initial concentration of DMBQ for W (0)=3, 5, 10, 15 and 20 (W (0)=[H2O]/[AOT]). The second-order rate constant (k (2)=k (obsd)/[DMBQ](0)) increased with an increase in the W (0) value, but was almost independent of the concentration of the water pool. A mechanism involving the distribution of DMBQ between the reverse micellar interface and bulk organic solvent was proposed to explain these findings.

en-copyright= kn-copyright= en-aut-name=UsuiDaisuke en-aut-sei=Usui en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SueishiYoshimi en-aut-sei=Sueishi en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamotoShunzo en-aut-sei=Yamamoto en-aut-mei=Shunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University en-keyword=reverse micelle kn-keyword=reverse micelle en-keyword=AOT kn-keyword=AOT en-keyword=oxidation kn-keyword=oxidation en-keyword=leuco methylene blue kn-keyword=leuco methylene blue en-keyword=kinetics kn-keyword=kinetics en-keyword=water pool kn-keyword=water pool END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=4 article-no= start-page=845 end-page=848 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200805 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improvement of piezoresistance properties of silicon carbide ceramics through co-doping of aluminum nitride and nitrogen en-subtitle= kn-subtitle= en-abstract= kn-abstract=The piezoresistance coefficient was measured on co-doped silicon carbide ceramics. Evaluation samples of alpha-silicon carbide ceramics were first fabricated by glass capsule HIP method using powder mixture of silicon carbide and aluminum nitride with various ratios. The resultant aluminum nitride added silicon carbide ceramics were doped with nitrogen by changing the post-HIP nitrogen gas pressure. The lattice parameter increased with the amount of adding aluminum nitride indicating that the incorporated aluminum substituted smaller silicon atoms. After post-HIP treatment, lattice parameter then decreased with nitrogen gas pressure. The piezoresistive coefficient increased with the addition of aluminum nitride, it further increased with the nitrogen doping pressure. en-copyright= kn-copyright= en-aut-name=KishimotoAkira en-aut-sei=Kishimoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkadaYasuyuki en-aut-sei=Okada en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HayashiHidetaka en-aut-sei=Hayashi en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=HIP kn-keyword=HIP en-keyword=co-doping kn-keyword=co-doping en-keyword=donor kn-keyword=donor en-keyword=acceptor kn-keyword=acceptor en-keyword=silicon carbide kn-keyword=silicon carbide en-keyword=strain sensor kn-keyword=strain sensor END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=2 article-no= start-page=108 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080921 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isolating primary cultures of osteocytes from chick calvaria, and, using anti-connexin 43 immunocytochemistry, demonstrate gap junction distribution to be comparable to that found in vivo. Next, we demonstrate the functionality of the gap junctions by (1) dye coupling studies that showed the spread of microinjected Lucifer Yellow from osteoblast to osteocyte and between adjacent osteocytes and (2) analysis of fluorescence replacement after photobleaching (FRAP), in which photobleaching of cells loaded with a membrane-permeable dye resulted in rapid recovery of fluorescence into the photobleached osteocyte, within 5 min postbleaching. This FRAP effect did not occur when cells were treated with a gap junction blocker (18 alpha-glycyrrhetinic acid), but replacement of fluorescence into the photobleached cell resumed when it was removed. These studies demonstrate that gap junctions are responsible for intercellular communication between adjacent osteocytes and between osteoblasts and osteocytes. This role is consistent with the ability of osteocytes to respond to and transmit signals over long distances while embedded in a calcified matrix.

en-copyright= kn-copyright= en-aut-name=KamiokaHiroshi en-aut-sei=Kamioka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshiharaYoshihito en-aut-sei=Ishihara en-aut-mei=Yoshihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RisHans en-aut-sei=Ris en-aut-mei=Hans kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurshidSakhr A. en-aut-sei=Murshid en-aut-mei=Sakhr A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugawaraYasuyo en-aut-sei=Sugawara en-aut-mei=Yasuyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamotoTeruko Takano en-aut-sei=Yamamoto en-aut-mei=Teruko Takano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=LimSoo-Siang en-aut-sei=Lim en-aut-mei=Soo-Siang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Zoology and Integrated Microscopy Resource, University of Wisconsin affil-num=4 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=National Science Foundation en-keyword=osteocytes kn-keyword=osteocytes en-keyword=osteoblasts kn-keyword=osteoblasts en-keyword=gap junctions kn-keyword=gap junctions en-keyword=intercellular communication kn-keyword=intercellular communication en-keyword=dye coupling kn-keyword=dye coupling en-keyword=FRAP kn-keyword=FRAP END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080813 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation and characterization of epitaxial Fe2-xTixO3 films with various Ti concentrations (0.5 < x < 1.0) en-subtitle= kn-subtitle= en-abstract= kn-abstract=

An ilmenite-hematite solid solution ( Fe2-xTixO3 ) is one of the candidates for practical magnetic semiconductors with a high Curie temperature. We have prepared well-crystallized epitaxial Fe2-xTixO3 films with a wide range of Ti concentrations - x=0.50, 0.60, 0.65, 0.76, 0.87, and 0.94 - on α-Al2O3(001) substrates. The films are prepared by a reactive helicon plasma sputtering technique to evaporate Fe and TiO targets simultaneously under optimized oxygen pressure conditions. The structural characterizations of the films reveal that all films have a single phase of the ordered structure with R3 symmetry, where Ti-rich and Fe-rich layers are stacked alternately along the c axis. All films have large ferrimagnetic moments at low temperature, and room temperature magnetization is clearly observed at x<0.7. The inverse temperature dependence of the resistivities of the films indicates their semiconducting behavior. The film resistivities decrease with decreasing Ti concentration.

en-copyright= kn-copyright= en-aut-name=TakadaY. en-aut-sei=Takada en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanishiM. en-aut-sei=Nakanishi en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiiT. en-aut-sei=Fujii en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakadaJ. en-aut-sei=Takada en-aut-mei=J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MuraokaY. en-aut-sei=Muraoka en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Department of Physics, Graduate School of Natural Science and Technology, Okayama University END