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Title Alternative Sexuality in plants, unveiled from genome evolution
FullText URL srfa_109_037_040.pdf
Author Akagi, Takashi|
Abstract Sexual polymorphism, a main strategy to maintain genetic diversity within a species, has long been a major focus in biology. Notwithstanding, in plants, evolution of sexual systems and mechanisms underlying these transitions have been little unveiled. We have elucidated the molecular mechanism of sex determination in persimmons (Diospyros spp.), where the Y-encoded smRNA gene OGI can repress the female-determining gene MeGI, and also in kiwifruits (Actinidia spp.), where the Y-encoded two sex determinants, Shy Girl and Friendly Boy, control gynoecium and androecium development, respectively. Although the molecular functions of these determinants are distinct, they have common evolutionary scenarios involving transitions of sexual systems. In persimmon, a recent genome triplication (hexaploidization) in cultivated persimmon (D. kaki) derived “flexible” sexuality via establishing epigenetic layers on the two sex determinants. On the other hand, an ancient Diospyros-specific paleo-genome duplication (paleo-tetraploidization) enabled neofunctionalization in the proto-MeGI, via positive selection, to establish a new function as a sex determinant. In kiwifruit, one of the two sex determinants, Shy Girl, was derived from neofunctionalization via Actinidia-specific duplication event. These findings exemplify how plant-specific numerous duplication events can drive flexible genetic material whose variation can be selected for development of new sexual systems.
Keywords Sex determination Sex chromosome Polyploidization Genome evolution Tree crops
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2020-02-01
Volume volume109
Start Page 37
End Page 40
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Mathematical analysis of copy number variation of 2 μ-based plasmids in yeast cells
FullText URL srfa_109_007_011.pdf
Author Saeki, Nozomu| Moriya, Hisao|
Abstract  Plasmids with the 2 μ plasmid origin are commonly-used in the genetic engineering of the budding yeast Saccharomyces cerevisiae. Intracellular copy numbers of 2 μ plasmids are different depending on the genes inserted into the plasmids. This difference is thought to occur from the difference in the growth efficiency (fitness) produced by the positive- and negative-selection biases of genes inserted in the plasmid. In this study, we made a mathematical model based on this assumption. Computational simulations of the model validated that copy numbers of the plasmids are rapidly settled depending on the fitness created by the gene on the plasmid. The copy number of a plasmid only contains a bias to keep the plasmid in a single copy became average 20copies per cell when the plasmid is randomly distributed, suggesting that no positive distribution mechanism is required for a plasmid to become multicopy.
Keywords yeast 2 μ plasmid mathematical model
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2020-02-01
Volume volume109
Start Page 7
End Page 11
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL JE36_161.pdf JE37_135.pdf
Author Matsumura, Kentarou| Miyatake, Takahisa|
Keywords Artificial selection Quantitative trait Relaxation of selection Reverse selection Tonic immobility Tribolium castaneum
Note Matsumura, K., Miyatake, T. Correction to: Responses to relaxed and reverse selection in strains artificially selected for duration of death‑feigning behavior in the red flour beetle, Tribolium castaneum. J Ethol 37, 135 (2019) doi:10.1007/s10164-018-0579-3|
Published Date 2018-04-04
Publication Title Journal of Ethology
Volume volume36
Issue issue2
Publisher Springer
Start Page 161
End Page 168
ISSN 0289-0771
NCID AA10754455
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.1007/s10164-018-0548-x
Web of Science KeyUT 000431173000007
Related Url isVersionOf https://doi.org/10.1007/s10164-018-0548-x isVersionOf https://doi.org/10.1007/s10164-018-0579-3
FullText URL GCA252_107.pdf
Author Kunihiro, Takuya| Ota, Tsutomu| Nakamura, Eizo|
Keywords Lithium Oxygen Chondrule Chondrite Asteroid Allende Igneous rim SIMS
Published Date 2019-05-01
Publication Title Geochimica et Cosmochimica Acta
Volume volume252
Publisher Elsevier
Start Page 107
End Page 125
ISSN 0016-7037
NCID AA00655038
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1016/j.gca.2019.02.038
Web of Science KeyUT 000462774200006
Related Url isVersionOf https://doi.org/10.1016/j.gca.2019.02.038
FullText URL JGPP_79_5_307.pdf
Author Tamada, Tetsuo| Kondo, Hideki|
Keywords Soil-borne viruses Benyvirus Furovirus Pecluvirus Pomovirus Bymovirus Vector transmission Plasmodiophorids Polymyxa Spongospora
Published Date 2013-05-28
Publication Title Journal of General Plant Pathology
Volume volume79
Issue issue5
Publisher Springer
Start Page 307
End Page 320
ISSN 1345-2630
NCID AA11449093
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1007/s10327-013-0457-3
Web of Science KeyUT 000323517200003
Related Url isVersionOf https://doi.org/10.1007/s10327-013-0457-3
JaLCDOI 10.18926/AMO/57370
FullText URL 73_5_403.pdf
Author Ando, Akemi| Mitsuhashi, Toshiharu| Honda, Mitsugi| Hanayama, Yoshihisa| Hasegawa, Kou| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio|
Abstract Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.
Keywords bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-10
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 403
End Page 411
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649366
Web of Science KeyUT 000491886600005
FullText URL VirusRes_262_37.pdf FIG_S1-7_revised.pdf TableS1-3.pdf
Author Kondo, Hideki| Chiba, Sotaro| Maruyama, Kazuyuki| Andika, Ida Bagus| Suzuki, Nobuhiro|
Keywords Bumblebee Endogenous viral element Evolution Insect Plant alpha-like virus Transcriptome shotgun assembly Whole genome shotgun assembly
Published Date 2019-03-31
Publication Title Virus Research
Volume volume262
Publisher Elsevier Science
Start Page 37
End Page 47
ISSN 01681702
NCID AA10642076
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2017 Elsevier B.V. All rights reserved.
File Version author
PubMed ID 29169832
DOI 10.1016/j.virusres.2017.11.020
Web of Science KeyUT 000459523800007
Related Url isVersionOf https://doi.org/10.1016/j.virusres.2017.11.020
FullText URL NatCom_10_1_3022.pdf
Author Belay, Iyasu Getachew| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Nakamura, Eizo|
Published Date 2019-07
Publication Title Nature Communications
Volume volume10
Issue issue1
Publisher Springer Nature Publishing AG
Start Page 3022
ISSN 20411723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31289264
DOI 10.1038/s41467-019-10832-7
Web of Science KeyUT 000474506700008
Related Url isVersionOf https://doi.org/10.1038/s41467-019-10832-7
FullText URL InfectGenetEvol_54_47.pdf
Author Ghosh, Priyanka| Kumar, Dhirendra| Chowdhury, Goutam| Singh, Puneeta| Samanta, Prosenjit| Dutta, Shanta| Ramamurthy, T.| Sharma, N. C.| Sinha, Preety| Prasad, Yogendra| Shinoda, Sumio| Mukhopadhyay, Asish K.|
Keywords Cholera Vibrio cholerae ctxAB promoter ctxB gyrA rstB rtxA tcpA
Published Date 2017-10
Publication Title Infection, Genetics and Evolution
Volume volume54
Publisher Elsevier Science
Start Page 47
End Page 53
ISSN 15671348
NCID AA11697619
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 28625543
DOI 10.1016/j.meegid.2017.06.015
Web of Science KeyUT 000411461400006
Related Url isVersionOf https://doi.org/10.1016/j.meegid.2017.06.015
JaLCDOI 10.18926/ESR/56694
FullText URL esr_025_031_038.pdf
Author Amano, Hideki| Suzuki, Shigeyuki| Sato, Masaru| Yanagida, Makoto|
Abstract The study area is situated in Japan Sea side margin of the Shakotan Peninsula, Hokkaido, Japan, where MIS5e Terrace is preserved along the cost. Numbers of tight drilling have done to establish new method for terrace analysis. Buried wave cut terrace and sea cliff (when the MIS5e Terrace was formed) are reconstructed by distribution of the terrace deposits and these bottom of unconformity planes. The precise site and altitude of former shoreline was also obtained. Altitudes of the former shoreline from the 7 sections are almost the same 22 to 27m in height. Previous data of the height of shoreline are obtained from the topographic MIS5e Terrace surface. The altitudes have variation from 30m to 60m. It suggests that the traditional method for the MIS5e terrace analysis had some errors in the study area.
Keywords MIS5e marine terrace terrace deposits tight drilling shoreline
Publication Title Okayama University Earth Science Report
Published Date 2018-12-27
Volume volume25
Issue issue1
Start Page 31
End Page 38
ISSN 1340-7414
language English
Copyright Holders © 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved
File Version publisher
JaLCDOI 10.18926/ESR/56692
Title Alternative Synoptic climatological analyses on the large day-to-day variation of air temperature around Germany in winter (Relating to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away)
FullText URL esr_025_007_017.pdf
Author Hamaki, Tatsuya| Kato, Kuranoshin| Otani, Kazuo| Kato, Haruko| Matsumoto, Kengo|
Abstract Synoptic climatological analyses associated with the large day-to-day variation of air temperature around Germany in winter were performed based mainly on the NCEP/NCAR reanalysis data for 2000/2001 to 2010/2011 winters, with an interest in the relationship to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away. The intermittent appearance of the extremely cold days with rather large day-to-day variation in winter as pointed out by Kato et al. (2017) for around Germany was seen also to the north and to the east of Germany. According to a case study for the 2000/2001 winter, such large daily mean temperature fluctuation was closely related to the intraseasonal variation of the Icelandic low with about one month period, i.e., while the temperature around Germany was relatively higher at the eastward shift phase of the Icelandic low due to the strong warm air advection by the SW-ly wind, the temperature was extremely low there when the Icelandic low was weakened and retreated westward.
Keywords Comparative climatology Climate around Europe Synoptic climatology on daily temperature variation in winter around Germany seasonal cycle and “seasonal feeling”
Publication Title Okayama University Earth Science Report
Published Date 2018-12-27
Volume volume25
Issue issue1
Start Page 7
End Page 17
ISSN 1340-7414
language Japanese
Copyright Holders © 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved
File Version publisher
FullText URL Vaccine_32_A20-8.pdf
Author Mullick, Satarupa| Mandal, Paulami| Mukti Kant Nayak| Ghosh, Souvik| De, Papiya| Rajendran, K.| Bhattacharya, Mihir K.| Mitra, Utpala| Ramamurthy, Thandavarayan| Kobayashi, Nobumichi| Chawla-Sarkar, Mamta|
Keywords Diarrhea Rotavirus India Kolkata G9 strains G2 strains
Published Date 2014-08-11
Publication Title Vaccine
Volume volume32
Issue issuesupplment 1
Publisher Elsevier Science
Start Page A20
End Page A28
ISSN 0264410X
NCID AA10491877
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 25091674
DOI 10.1016/j.vaccine.2014.03.018
Web of Science KeyUT 000340977500007
Related Url isVersionOf https://doi.org/10.1016/j.vaccine.2014.03.018
FullText URL Front_Microbiol_7_1250.pdf
Author Ghosh, Raikamal| Sharma, Naresh C.| Halder, Kalpataru| Bhadra, Rupak K.| Chowdhury, Goutam| Pazhani, Gururaja P.| Shinoda, Sumio| Mukhopadhyay, Asish K.| Nair, G. Balakrish| Ramamurthy, Thadavarayan|
Keywords V.cholerae O139 ribotypes CT genotype CTX prophage PFGE
Published Date 2016-08-09
Publication Title frontiers in Microbiology
Volume volume7
Publisher Frontiers Media S.A.
Start Page 1250
ISSN 1664302X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 27555841
DOI 10.3389/fmicb.2016.01250
Web of Science KeyUT 000381079700001
Related Url isVersionOf https://doi.org/10.3389/fmicb.2016.01250
FullText URL Plos_Negl_Trop_Dis_5386.pdf
Author Imamura, Daisuke| Morita, Masatomo| Sekizuka, Tsuyoshi| Mizuno, Tamaki| Takemura, Taichiro| Yamashiro, Tetsu| Chowdhury, Goutam| Pazhani, Gururaja P.| Mukhopadhyay, Asish K.| Ramamurthy, Thandavarayan| Miyoshi, Shin-ichi| Kuroda, Makoto| Shinoda, Sumio| Ohnishi, Makoto|
Note This research is supported by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan, and Japan Agency for Medical Research and Development (AMED).|
Published Date 2017-02-13
Publication Title PLOS Neglected Tropical Diseases
Volume volume11
Issue issue2
Publisher PLOS
Start Page e0005386
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 28192431
DOI 10.1371/journal.pntd.0005386
Web of Science KeyUT 000396406600020
Related Url isVersionOf https://doi.org/10.1371/journal.pntd.0005386
FullText URL Geochem_Cosmochi_Act_235_76.pdf
Author Inoue, Mayuri| Nakamura, Takashi| Tanaka, Yasuaki| Suzuki, Atsushi| Yokoyama, Yusuke| Kawahata, Hodaka| Sakai, Kazuhiko| Gussone, Nikolaus|
Keywords Coral symbiosis calcification pH geochemical tracers
Note This is an Accepted Manuscript of an article published by Elsevier B.V.|
Published Date 2018-08-15
Publication Title Geochimica et Cosmochimica Acta
Volume volume235
Publisher Elsevier B.V.
Start Page 76
End Page 88
ISSN 00167037
NCID AA00655038
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1016/j.gca.2018.05.016
Related Url isVersionOf https://doi.org/10.1016/j.gca.2018.05.016
FullText URL PhysRevB_97_094525.pdf
Author Terashima, K.| Paris, E.| Simonelli, L.| Salas-Colera, E.| Puri, A.| Wakita, T.| Yamada, Y.| Nakano, S.| Idei, H.| Kudo, K.| Nohara, M.| Muraoka, Y.| Mizokawa, T.| Yokoya, T.| Saini, N. L.|
Note This is an article published by American Physical Society|
Published Date 2018-09-28
Publication Title Physical Review B
Volume volume98
Issue issue9
Publisher American Physical Society
Start Page 094525
ISSN 24699950
NCID AA11187113
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.1103/PhysRevB.98.094525
Web of Science KeyUT 000446178800008
Related Url isVersionOf https://doi.org/10.1103/PhysRevB.98.094525
JaLCDOI 10.18926/AMO/56182
FullText URL 72_4_423.pdf
Author Sakakida, Kourin| Wei, Fan-Yan| Senokuchi, Takafumi| Shimoda, Seiya| Kakuma, Tatsuyuki| Araki, Eiichi| Tomizawa, Kazuhito| The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group|
Abstract Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.
Keywords diabetes insulin secretion single nucleotide polymorphism glucose
Amo Type Clinical Study Protocol
Publication Title Acta Medica Okayama
Published Date 2018-08
Volume volume72
Issue issue4
Publisher Okayama University Medical School
Start Page 423
End Page 426
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30140092
JaLCDOI 10.18926/AMO/56073
FullText URL 72_3_275.pdf
Author Morizane, Shin| Ouchida, Mamoru| Sunagawa, Ko| Sugimoto, Saeko| Kobashi, Mina| Sugihara, Satoru| Nomura, Hayato| Tsuji, Kazuhide| Sato, Atsushi| Miura, Yoshihiro| Hattori, Hiroaki| Tada, Kotaro| Huh, Wook-Kang| Seno, Akemi| Iwatsuki, Keiji|
Abstract Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients.
Keywords atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-06
Volume volume72
Issue issue3
Publisher Okayama University Medical School
Start Page 275
End Page 282
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29926005
FullText URL PhysRevB_95_245310.pdf
Author Uesugi, Eri| Miao, Xiao| Ota, Hiromi| Goto, Hidenori| Kubozono, Yoshihiro|
Note This is an article published by American Physical Society|
Published Date 2017-01
Publication Title Physical Review B
Volume volume95
Issue issue24
Publisher American Physical Society
Start Page 245310
ISSN 2469-9950
NCID AA11187113
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders American Physical Society
File Version publisher
DOI 10.1103/PhysRevB.95.245310
Web of Science KeyUT 000403355300005
Related Url isVersionOf https://doi.org/10.1103/PhysRevB.95.245310
FullText URL PhysRevB_95_064512.pdf
Author Ichioka, Masanori| Kogan, V. G.| Schmalian, J.|
Note This is an article published by American Physical Society|
Published Date 2017-02
Publication Title Physical Review B
Volume volume95
Issue issue6
Publisher American Physical Society
Start Page 064512
ISSN 2469-9950
NCID AA11187113
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2017 American Physical Society
File Version publisher
DOI 10.1103/PhysRevB.95.064512
Web of Science KeyUT 000394657300012
Related Url isVersionOf https://doi.org/10.1103/PhysRevB.95.064512