result 1271 件
Title Alternative | Evaluator of adaptability of S. cerevisiae to grape juice using the oversxpression profiling ADOPT method |
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FullText URL | srfa_113_001_006.pdf |
Author | Moriya, Hisao| Ono, Chiyuki Kohata | |
Abstract | The authors have recently developed the overexpression profiling ADOPT method. In the ADOPT method, yeast strains overexpressing most of the genes in the budding yeast Saccharomyces cerevisiae genome are mixed and competitively cultured, and the genes overexpressed in the enriched strains are systematically identified. Furthermore, the identified genes can be used to identify bottleneck factors that are necessary but lacking for growth of S. cerevisiae under given conditions. In our previous studies, we have identified bottlenecks in artificially created stress environments in the laboratory, but in this study, we used grape juice for winemaking as an example to see if industrial bottlenecks can be identified. ADOPT experiments with sulfite-added grape juice used in conventional winemaking resulted in a strong enrichment of strains overexpressing the sulfite pump SSU1 and its transcription factor FZF1. Since enhancement of SSU1 function is known to occur in wine yeast acclimation, ADOPT was also shown to be useful in the search for industrial bottlenecks. On the other hand, no genes were strongly enriched by ADOPT in grape juice without sulfite addition, suggesting that grape juice is a balanced medium with few bottlenecks for S. cerevisiae growth. |
Keywords | yeast S. cerevisiae overexpression wine making |
Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
Published Date | 2024-02-01 |
Volume | volume113 |
Start Page | 1 |
End Page | 6 |
ISSN | 2186-7755 |
language | Japanese |
File Version | publisher |
FullText URL | fulltext20240205-01.pdf |
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Author | Tokushige, Keisuke| Abe, Takumi| |
Keywords | C3-N1' bisindoles bromination umpolung rivularin A alkaloid |
Note | This is the peer reviewed version of the following article: [K. Tokushige, T. Abe, Chem. Eur. J. 2024, 30, e202302963. https://doi.org/10.1002/chem.202302963], which has been published in final form at [https://doi.org/10.1002/chem.202302963]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jan. 2025.| |
Published Date | 2024-01-08 |
Publication Title | Chemistry – A European Journal |
Volume | volume30 |
Issue | issue11 |
Publisher | Wiley |
Start Page | e202302963 |
ISSN | 0947-6539 |
NCID | AA11076269 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Wiley-VCH GmbH |
File Version | author |
PubMed ID | 37988219 |
DOI | 10.1002/chem.202302963 |
Web of Science KeyUT | 001142083100001 |
Related Url | isVersionOf https://doi.org/10.1002/chem.202302963 |
FullText URL | fulltext.pdf |
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Author | Hashimoto, Mana| Takahashi, Haruka| Tabata-Okubo, Kaori| Nagaoka, Noriyuki| Tokunaga, Kazuaki| Matsumori, Haruka| Ishihara, Yoshihito| Kaku, Masaru| Iimura, Tadahiro| Hara, Toru| Kamioka, Hiroshi| |
Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-48786-y| |
Published Date | 2023-12-12 |
Publication Title | Scientific Reports |
Volume | volume13 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 22028 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 38086873 |
DOI | 10.1038/s41598-023-48786-y |
Web of Science KeyUT | 001126179100035 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-023-48786-y |
FullText URL | fulltext.pdf |
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Author | Kobayashi, Hiroki| Ouchi, Tomoki| Kitamura, Wataru| Asakura, Shoji| Yano, Tomofumi| Takeda, Hiromasa| Tokuda, Yoshiyuki| Yoshino, Tadashi| Maeda, Yoshinobu| |
Keywords | cold agglutinin disease severe acute respiratory syndrome coronavirus 2 sutimlimab |
Published Date | 2023-12-26 |
Publication Title | Journal of Clinical and Experimental Hematopathology |
Volume | volume63 |
Issue | issue4 |
Publisher | The Japanese Society for Lymphoreticular Tissue Research |
Start Page | 246 |
End Page | 250 |
ISSN | 1346-4280 |
NCID | AA11556796 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Japanese Society for Lymphoreticular Tissue Research |
File Version | publisher |
PubMed ID | 38148014 |
DOI | 10.3960/jslrt.23040 |
Web of Science KeyUT | 001134578000003 |
Related Url | isVersionOf https://doi.org/10.3960/jslrt.23040 |
FullText URL | fulltext.pdf |
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Author | Kato, Yusuke| Kuroda, Hiroshi| Ozawa, Shin-Ichiro| Saito, Keisuke| Dogra, Vivek| Scholz, Martin| Zhang, Guoxian| de Vitry, Catherine| Ishikita, Hiroshi| Kim, Chanhong| Hippler, Michael| Takahashi, Yuichiro| Sakamoto, Wataru| |
Keywords | post-translational modification Arabidopsis thaliana protein degradation photosystem II photo-oxidative damage tryptophan oxidation Chlamydomonas reinhardtii |
Published Date | 2023-11-21 |
Publication Title | eLife |
Volume | volume12 |
Publisher | eLife Sciences Publications |
Start Page | RP88822 |
ISSN | 2050-084X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Kato, Kuroda, Ozawa et al. |
File Version | publisher |
PubMed ID | 37986577 |
DOI | 10.7554/eLife.88822 |
Web of Science KeyUT | 001134641800001 |
Related Url | isVersionOf https://doi.org/10.7554/eLife.88822 |
FullText URL | fulltext20240213-01.pdf |
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Author | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
Published Date | 2023-12-14 |
Publication Title | Blood Advances |
Volume | volume7 |
Issue | issue24 |
Publisher | American Society of Hematology |
Start Page | 7459 |
End Page | 7470 |
ISSN | 2473-9529 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by The American Society of Hematology. |
File Version | publisher |
PubMed ID | 37552496 |
DOI | 10.1182/bloodadvances.2023010402 |
Web of Science KeyUT | 001141306600001 |
Related Url | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
FullText URL | fulltext.pdf |
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Author | Tsuji, Kenji| Nakanoh, Hiroyuki| Takahashi, Kensaku| Morita, Takafumi| Sang, Yizhen| Fukushima, Kazuhiko| Matsuoka-Uchiyama, Natsumi| Onishi, Yasuhiro| Uchida, Haruhito A.| Kitamura, Shinji| Wada, Jun| |
Published Date | 2023-12 |
Publication Title | Kidney Medicine |
Volume | volume5 |
Issue | issue12 |
Publisher | Elsevier |
Start Page | 100733 |
ISSN | 2590-0595 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 38046910 |
DOI | 10.1016/j.xkme.2023.100733 |
Web of Science KeyUT | 001124701500001 |
Related Url | isVersionOf https://doi.org/10.1016/j.xkme.2023.100733 |
Author | Tada, Naoya| Uemori, Takeshi| Sakamoto, Junji| |
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Keywords | Mechanical engineering Microdevices made of thin metal sheet Pure titanium Deformation Microscopic characterization and microanalysis Plastic deformation Microscopic inhomogeneity and stress concentration Slip activity control |
Note | © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Sep. 2025.| |
Published Date | 2023-11 |
Publication Title | Engineering Failure Analysis |
Volume | volume153 |
Publisher | Elsevier |
Start Page | 107623 |
ISSN | 1350-6307 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier Ltd. |
File Version | author |
DOI | 10.1016/j.engfailanal.2023.107623 |
Web of Science KeyUT | 001148684500001 |
Related Url | isVersionOf https://doi.org/10.1016/j.engfailanal.2023.107623 |
FullText URL | fulltext20240208-01.pdf |
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Author | Ratnayake, Dilan M.| Tanaka, Ryoji| Nakamura, Eizo| |
Keywords | Cr isotopes DS-TE-TIMS Cation exchange resin Low blank High precision |
Note | © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2024.| |
Published Date | 2023-10-16 |
Publication Title | Analytica Chimica Acta |
Volume | volume1278 |
Publisher | Elsevier |
Start Page | 341723 |
ISSN | 0003-2670 |
NCID | AA00524834 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier B.V. |
File Version | author |
PubMed ID | 37709464 |
DOI | 10.1016/j.aca.2023.341723 |
Web of Science KeyUT | 001069672800001 |
Related Url | isVersionOf https://doi.org/10.1016/j.aca.2023.341723 |
FullText URL | fulltext20240226-02.pdf |
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Author | Ikeda, Hideki| Nagasaki, Joji| Shimizu, Daiki| Katsuya, Yuki| Horinouchi, Hidehito| Hosomi, Yukio| Tanji, Etsuko| Iwata, Takekazu| Itami, Makiko| Kawazu, Masahito| Ohe, Yuichiro| Suzuki, Takuji| Togashi, Yosuke| |
Keywords | Thymic epithelial tumor Cancer immunotherapy CD80/CD86 MHC Memory precursor effector T cell |
Published Date | 2023-10 |
Publication Title | JTO Clinical and Research Reports |
Volume | volume4 |
Issue | issue10 |
Publisher | Elsevier |
Start Page | 100573 |
ISSN | 2666-3643 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 37799325 |
DOI | 10.1016/j.jtocrr.2023.100573 |
Web of Science KeyUT | 001161095400001 |
Related Url | isVersionOf https://doi.org/10.1016/j.jtocrr.2023.100573 |
FullText URL | fulltext20240206-04.pdf |
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Author | Sato, Yukiyo| Suzuki, Nobuhiro| |
Note | © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jun. 2024.| |
Published Date | 2023-10 |
Publication Title | Current Opinion in Microbiology |
Volume | volume75 |
Publisher | Elsevier |
Start Page | 102337 |
ISSN | 1369-5274 |
NCID | AA11313229 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier Ltd. |
File Version | author |
PubMed ID | 37343415 |
DOI | 10.1016/j.mib.2023.102337 |
Web of Science KeyUT | 001025990600001 |
Related Url | isVersionOf https://doi.org/10.1016/j.mib.2023.102337 |
FullText URL | fulltext20240109-01.pdf fig1_20240109-01.pdf fig2_20240109-01.pdf fig3_20240109-01.pdf fig4_20240109-01.pdf |
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Author | Okada, Koki| Morimoto, Yu| Shiraishi, Yukine| Tamura, Takashi| Mayama, Shigeki| Kadono, Takashi| Adachi, Masao| Ifuku, Kentaro| Nemoto, Michiko| |
Keywords | Diatom Genetic transformation Nitzschia Multi-pulse electroporation |
Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10126-023-10273-w| This fulltext file will be available in Dec. 2024.| |
Published Date | 2023-12-10 |
Publication Title | Marine Biotechnology |
Volume | volume25 |
Issue | issue6 |
Publisher | Springer Science and Business Media LLC |
Start Page | 1208 |
End Page | 1219 |
ISSN | 1436-2228 |
NCID | AA11357643 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023 |
File Version | author |
PubMed ID | 38071657 |
DOI | 10.1007/s10126-023-10273-w |
Web of Science KeyUT | 001120097200001 |
Related Url | isVersionOf https://doi.org/10.1007/s10126-023-10273-w |
FullText URL | fulltext.pdf |
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Author | Ando, Kakeru| Watanabe, Minoru| Watanabe, Nobuya| |
Note | © 2023 Optica Publishing Group. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.| |
Published Date | 2023-11-06 |
Publication Title | Optics Express |
Volume | volume31 |
Issue | issue23 |
Publisher | Optica Publishing Group |
Start Page | 38529 |
End Page | 38539 |
ISSN | 1094-4087 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement |
File Version | publisher |
PubMed ID | 38017956 |
DOI | 10.1364/OE.500666 |
Web of Science KeyUT | 001108090500007 |
Related Url | isVersionOf https://doi.org/10.1364/OE.500666 |
FullText URL | fulltext.pdf |
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Author | Tsukioki, Takahiro| Khan, Seema A.| Shien, Tadahiko| |
Keywords | Breast cancer Prevention Risk reduction mastectomy Chemoprevention Methylation |
Note | The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00287-0| |
Published Date | 2023-12-12 |
Publication Title | Genes and Environment |
Volume | volume45 |
Issue | issue1 |
Publisher | BMC |
Start Page | 35 |
ISSN | 1880-7046 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023. |
File Version | publisher |
PubMed ID | 38082340 |
DOI | 10.1186/s41021-023-00287-0 |
Web of Science KeyUT | 001121724100001 |
Related Url | isVersionOf https://doi.org/10.1186/s41021-023-00287-0 |
FullText URL | fulltext.pdf |
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Author | Shimooka, So| Himuro, Hiroki| Gofuku, Akio| |
Keywords | hexagonal pyramid shape of flexible actuator anisotropic stiffness extension-type flexible pneumatic actuator analytical model of shape |
Published Date | 2023-11-14 |
Publication Title | Actuators |
Volume | volume12 |
Issue | issue11 |
Publisher | MDPI |
Start Page | 424 |
ISSN | 2076-0825 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
DOI | 10.3390/act12110424 |
Web of Science KeyUT | 001120904300001 |
Related Url | isVersionOf https://doi.org/10.3390/act12110424 |
FullText URL | fulltext.pdf |
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Author | Miyazaki, Midoka| Asakura, Mami| Ide, Toru| Hayakawa, Tohru| |
Keywords | mosquito-larvicidal toxin Bacillus thuringiensis TK-E6 Culex pipiens mosquito larvae site-directed mutagenesis electrophysiologic analysis |
Published Date | 2023-12-01 |
Publication Title | Biology |
Volume | volume12 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 1481 |
ISSN | 2079-7737 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 38132307 |
DOI | 10.3390/biology12121481 |
Web of Science KeyUT | 001132518500001 |
Related Url | isVersionOf https://doi.org/10.3390/biology12121481 |
Title Alternative | Parameter study of strong ground motion simulation for the Median Tectonic Line in the case of the Iyo-Bungo Earthquake of September 1st, 1596 |
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JaLCDOI | 10.18926/66189 |
FullText URL | jdc_003_021.pdf |
Author | OKUMA, Yurie| KUMAMOTO, Takashi| |
Abstract | The purpose of this study is to verify the fault length and earthquake magnitude of the Iyo-Bungo earthquake in 1596 estimated by Ishibashi (2019) using historical documents written in the same period. According to Ishibashi (2019), the length of the source fault was estimated to have been less than 100 km and the earthquake magnitude was roughly estimated to have been around 7.5. In order to attempt to reproduce the interpretation, we conducted two different strong ground motion simulations: the attenuation equation method and the characterized source model method, both used in the Headquarters for Earthquake Research Promotion. We simulated earthquake ground motions based on several source fault models including estimation by Ishibashi (2019). For the length of the fault, a 100 km length corresponding to the Iyonada segment of the Median Tectonic Line active fault system was the first model and 130 km and 160 km models extending onshore to the northeast were taken into account as epistemic uncertainties. Regarding the dip angle of the fault, both 40 and 90 degree models were considered also as epistemic uncertainties. Our calculation with other uncertainties shows that the models with a fault length of 100 km with a dip angle of 90 or 40 degrees are consistent with the seismic intensity and seismogenic fault length of offshore fault estimated by Ishibashi (2019) based on reliable first-grade documents. If low-certainty intensity estimates by Ishibashi (2019) are used to evaluate fault length in our calculation, the possibility of 130 or 160 km length models with additional onshore faults will remain. Our results show that the strong ground motion simulation could reinforce the expert’s interpretation of historical documents and propose quantitative source fault models for historical earthquakes. |
Keywords | Median Tectonic Line 1596 Iyo-Bungo earthquake strong ground motion simulation epistemic uncertainties |
Amo Type | 論文 (Research article) |
Publication Title | Dynamics of Civilizations |
Published Date | 2024-03-25 |
Volume | volume3 |
Publisher | 岡山大学文明動態学研究所 |
Start Page | 21 |
End Page | 40 |
ISSN | 2436-8326 |
Content Type | Journal Article |
language | Japanese |
Copyright Holders | © 2024 by RIDC |
File Version | publisher |
FullText URL | fulltext.pdf |
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Author | Yamashita, Toru| Nakano, Yumiko| Sasaki, Ryo| Tadokoro, Koh| Omote, Yoshio| Yunoki, Taijun| Kawahara, Yuko| Matsumoto, Namiko| Taira, Yuki| Matsuoka, Chika| Morihara, Ryuta| Abe, Koji| |
Keywords | amyotrophic lateral sclerosis clinical trial CL2020 multilineage-differentiating stress-enduring (Muse) cells intravenous administration |
Published Date | 2023 |
Publication Title | Cell Transplantation |
Volume | volume32 |
Publisher | SAGE Publications |
ISSN | 0963-6897 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 38014622 |
DOI | 10.1177/09636897231214370 |
Web of Science KeyUT | 001109624600001 |
Related Url | isVersionOf https://doi.org/10.1177/09636897231214370 |
JaLCDOI | 10.18926/AMO/66148 |
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FullText URL | 77_6_567.pdf |
Author | Matsumoto, Naomi| Higuchi, Chigusa| Miyaji, Chikara| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi| |
Abstract | This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic. |
Keywords | coronavirus disease 2019 adverse reactions mRNA vaccine antibody titers young adults |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2023-12 |
Volume | volume77 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 567 |
End Page | 575 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 38145930 |
Web of Science KeyUT | 001164631200001 |
FullText URL | fulltext20231129-01.pdf |
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Author | Taira, Aoi| Okamoto, Ryuichi| Sumi, Tomonari| Koga, Kenichiro| |
Published Date | 2023 |
Publication Title | Physical Chemistry Chemical Physics |
Volume | volume25 |
Issue | issue45 |
Publisher | Royal Society of Chemistry (RSC) |
Start Page | 31107 |
End Page | 31117 |
ISSN | 1463-9076 |
NCID | AA11301773 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © the Owner Societies 2023 |
File Version | publisher |
PubMed ID | 37947179 |
DOI | 10.1039/d3cp03799a |
Web of Science KeyUT | 001099200400001 |
Related Url | isVersionOf https://doi.org/10.1039/d3cp03799a |