result 1670 件
| JaLCDOI | 10.18926/AMO/70074 |
|---|---|
| FullText URL | 80_1_063.pdf |
| Author | Takasu, Eri| Shiode, Yusuke| Kindo, Hiroya| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Morita, Tetsuro| Adachi, Takuya| Otsuka, Motoyuki| Morizane, Yuki| |
| Abstract | A 77-year-old man undergoing treatment for hepatocellular carcinoma (HCC) presented with blurred vision in his right eye, persisting for 2 months. Slit-lamp microscopy and fundus examination revealed inflammatory cells in the anterior chamber, severe vitreous opacities, and retinal vasculitis in the right eye. The patient underwent vitreous surgery with biopsy, and vitreous cytology confirmed a metastatic intraocular tumor originating from the HCC. Radiotherapy was administered to the right eye, with no recurrence of intraocular inflammation observed at 10 months post-irradiation. |
| Keywords | metastatic intraocular tumor hepatocellular carcinoma panuveitis uveitis masquerade syndrome |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 67 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748151 |
| Web of Science KeyUT | 001712997700001 |
| JaLCDOI | 10.18926/AMO/70073 |
|---|---|
| FullText URL | 80_1_055.pdf |
| Author | Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Yamamoto, Shohei| Nakano, Yasuhiro| Otsuka, Fumio| |
| Abstract | In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations. |
| Keywords | coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 55 |
| End Page | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748150 |
| Web of Science KeyUT | 001712994500007 |
| JaLCDOI | 10.18926/AMO/70069 |
|---|---|
| FullText URL | 80_1_017.pdf |
| Author | Yano, Hideki| Takahata, Yoko| Yamaguchi, Takeshi| Saito, Shinya| |
| Abstract | This study aimed to develop a scale enabling nurses to objectively evaluate their own stroke discharge support, as a basis for enhancing its overall effectiveness. A draft scale was created based on a literature review, and consisted of a 51-item, 5-point Likert-type questionnaire administered to ward nurses engaged in stroke discharge support at acute care hospitals. Factor analysis was performed to refine the scale. Construct validity was assessed using the known-groups method, and reliability was evaluated through internal consistency analysis. The resulting Stroke Discharge Support Evaluation Scale comprises 29 items across 5 factors, each rated on a 5-point Likert scale. Analysis of the data collected from 237 valid responses demonstrated good internal consistency and supported the scale’s construct validity. The Stroke Discharge Support Evaluation Scale is a reliable and valid tool enabling ward nurses in acute care hospitals to evaluate their own stroke discharge support. |
| Keywords | stroke discharge support scale development |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748146 |
| Web of Science KeyUT | 001712994500003 |
| JaLCDOI | 10.18926/AMO/70068 |
|---|---|
| FullText URL | 80_1_009.pdf |
| Author | Sugahara, Kentaro| Kondo, Takashi| Miyatake, Nobuyuki| Nishi, Hiroyuki| Ujike, Kazuhiro| Koumoto, Kiichi| Namio, Keiichi| Hishii, Shuhei| Katayama, Akihiko| Suzuki, Hiromi| Yamamoto, Yorimasa| |
| Abstract | Appropriate treatments for chronic hemodialysis patients are a public health challenge in Japan. Sedentary behavior appears to be closely associated with these patients’ survival. We thus sought to develop a nomogram that predicts survival based on the duration of chronic hemodialysis patients’ sedentary behavior. One hundred twenty-four patients under chronic hemodialysis (73 men, 51 women, age 71.7±11.1 years) were enrolled in this cohort study. The patients wore a triaxial accelerometer that measured both their sedentary behavior, i.e., total sedentary behavior (minutes) and their maximum sedentary bouts (min) on non-hemodialysis days. We obtained the Kaplan-Meier curve and used the log-rank test and a Cox proportional hazards model to evaluate the relationship between the patients’ sedentary behavior and their survival. We also used a Cox proportional hazards model to develop a nomogram for the patients’ 5-year survival rate. Forty-six patients died during the follow-up period. When we stratified the patients by the medians of total sedentary behavior and maximum sedentary bouts, we observed significant between-group differences. After adjustment for confounding factors in a Cox proportional hazards model, total sedentary behavior and maximum sedentary bouts were identified as critical survival factors, and we generated a nomogram using an index of sedentary behavior. Our analysis results demonstrated that sedentary behavior on non-dialysis days was closely associated with the survival of the chronic hemodialysis patients, suggesting that a decrease in sedentary behavior would prolong their survival. The nomogram developed herein based on sedentary behavior may be useful for predicting the outcomes of chronic hemodialysis patients. |
| Keywords | nomogram chronic hemodialysis sedentary behavior Cox proportional hazards model Kaplan- Meier curve |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748145 |
| Web of Science KeyUT | 001712994500002 |
| JaLCDOI | 10.18926/70057 |
|---|---|
| FullText URL | jdc_005_101.pdf |
| Author | TILLONEN, Mia| |
| Abstract | Every year in November, the Tori no Ichi festival draws huge crowds to the grounds of Hanazono Shrine in Shinjuku, Tokyo. The festival is centered around the buying and selling of kumade, or good luck rakes. These bold and colorful objects function as engimono, or good luck charms, purchased for business prosperity or home safety. This study explores the circulation and itinerary of kumade at the Tori no Ichi festival by analyzing the performances surrounding them. While previous scholarship on engimono has focused on their roles in domestic settings or disposal rituals, this research approaches them in situ at the festival. The study shows that these objects bridge the festival and the everyday, connecting people to the event and the sacred site through a dynamic network of social, spatial, and ritual practices. The research draws on fieldwork and in-depth interviews conducted at Hanazono Shrine between 2020 and 2024. |
| Keywords | urban festival material religion sacred object performance Tokyo |
| Amo Type | 特集:Sacred Objects in Religions (Special Issue: Sacred Objects in Religions) |
| Publication Title | Dynamics of Civilizations |
| Published Date | 2026-03 |
| Volume | volume5 |
| Publisher | 岡山大学文明動態学研究所 |
| Start Page | 101 |
| End Page | 114 |
| ISSN | 2436-8326 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | © 2025 by RIDC |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sulistyorini, Dewie| Huq, K A T M Ehsanul| Babaita, Abdulfatai Olamilekan| Aivey, Sadia A| Huiying, Gao| Kazawa, Kana| Fukushima, Yasuko| Kako, Mayumi| Moriyama, Michiko| |
| Published Date | 2025-12 |
| Publication Title | BMJ Open |
| Volume | volume15 |
| Issue | issue12 |
| Publisher | BMJ |
| Start Page | e095428 |
| ISSN | 2044-6055 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2025. |
| File Version | publisher |
| PubMed ID | 41469067 |
| DOI | 10.1136/bmjopen-2024-095428 |
| Web of Science KeyUT | 001651098600001 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjopen-2024-095428 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okamoto, Soichiro| Matsui, Yusuke| Tomita, Koji| Munetomo, Kazuaki| Umakoshi, Noriyuki| Mitsuhashi, Toshiharu| Iguchi, Toshihiro| Hiraki, Takao| |
| Keywords | pneumothorax lung biopsy image-guided biopsy needle tract sealing |
| Published Date | 2025-12-29 |
| Publication Title | Interventional Radiology |
| Volume | volume10 |
| Publisher | The Japanese Society of Interventional Radiology |
| Start Page | e2025-0068 |
| ISSN | 2432-0935 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Japanese Society of Interventional Radiology |
| File Version | publisher |
| DOI | 10.22575/interventionalradiology.2025-0068 |
| Web of Science KeyUT | 001652148600005 |
| Related Url | isVersionOf https://doi.org/10.22575/interventionalradiology.2025-0068 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukaya-Shiba, Ai| Ogata, Akiko| Kuribayashi, Ryosuke| Sakurai, Akira| Suzuki, Kanako| Takadama, Shunsuke| Nishimura, Jihei| Uchiyama, Jumpei| Ohge, Hiroki| Takeuchi, Takamasa| Tamaki, Hideyuki| Matsumoto, Tetsuya| Kiga, Kotaro| Iwano, Hidetomo| |
| Keywords | phage therapy bacteriophage antimicrobial resistance (AMR) quality considerations non-clinical evaluation clinical trial plan the Cartagena Act |
| Published Date | 2025-12-18 |
| Publication Title | Frontiers in Pharmacology |
| Volume | volume16 |
| Publisher | Frontiers Media SA |
| Start Page | 1713471 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Fukaya-Shiba, Ogata, Kuribayashi, Sakurai, Suzuki, Takadama, Nishimura, Uchiyama, Ohge, Takeuchi, Tamaki, Matsumoto, Kiga and Iwano. |
| File Version | publisher |
| PubMed ID | 41487519 |
| DOI | 10.3389/fphar.2025.1713471 |
| Web of Science KeyUT | 001652023300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2025.1713471 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukushima, Shinnosuke| Fujimori, Takumi| Iio, Koji| Hagiya, Hideharu| |
| Keywords | bloodstream infection brain abscess mixed infection |
| Published Date | 2025-02 |
| Publication Title | JACEP Open |
| Volume | volume6 |
| Issue | issue1 |
| Publisher | Elsevier BV |
| Start Page | 100026 |
| ISSN | 2688-1152 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 40012669 |
| DOI | 10.1016/j.acepjo.2024.100026 |
| Web of Science KeyUT | 001443867900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.acepjo.2024.100026 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kamada, Naruto| Hagiya, Hideharu| Kutsuna, Satoshi| |
| Published Date | 2025-09-04 |
| Publication Title | PLOS One |
| Volume | volume20 |
| Issue | issue9 |
| Publisher | Public Library of Science (PLoS) |
| Start Page | e0329451 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Kamada et al. |
| File Version | publisher |
| PubMed ID | 40906766 |
| DOI | 10.1371/journal.pone.0329451 |
| Web of Science KeyUT | 001565914000030 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0329451 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Tsuji, Shuma| Iio, Koji| Matsushita, Osamu| |
| Keywords | Antimicrobial resistance Invasive meningococcal disease Drug-resistant gene Genome sequence |
| Published Date | 2025-03 |
| Publication Title | IJID Regions |
| Volume | volume14 |
| Publisher | Elsevier BV |
| Start Page | 100511 |
| ISSN | 2772-7076 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39835185 |
| DOI | 10.1016/j.ijregi.2024.100511 |
| Web of Science KeyUT | 001410378200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ijregi.2024.100511 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bai, Lanlan| Wu, Tao| Fukasawa, Mizuki| Kashiwagi, Sayo| Tate, Haruka| Ozaki, Taku| Sugano, Eriko| Tomita, Hiroshi| Ishii, Tsuyoshi| Akashi, Takuya| Fukuda, Tomokazu| |
| Keywords | Dermal papilla cell Nuclear translocation Androgen receptor Live cell imaging Digital image analysis Quantitation algorithm |
| Published Date | 2025-04 |
| Publication Title | Tissue and Cell |
| Volume | volume93 |
| Publisher | Elsevier BV |
| Start Page | 102631 |
| ISSN | 0040-8166 |
| NCID | AA00863829 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39718068 |
| DOI | 10.1016/j.tice.2024.102631 |
| Web of Science KeyUT | 001393720800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.tice.2024.102631 |
| Title Alternative | The results of COVID-19 antibody testing studies in Bizen, Japan |
|---|---|
| Author | Yorifuji, Takashi| Sasaki, Ayako| Matsumoto, Naomi| Kadowaki, Tomoka| Mitsuhashi, Toshiharu| Takao, Soshi| |
| Abstract | We conducted two prospective cohort studies (June 2022–March 2023 and Nov 2023–Jan 2024) of 1,899 and 445 residents and other individuals who are affiliated with institutions in the city of Bizen in Japan's Okayama prefecture (population 32,320 as of 2020). We measured the subjects' titers of antibodies against SARS-CoV-2, evaluated changes in their antibody titers, and assessed the associations of the titers with the subjects' vaccination status, infection, and COVID-19 status/severity. This report summarizes the two studies' findings. These prospective studies based on a wide age range in a general population provide information that can be used to determine the appropriate timing of vaccination during a pandemic. |
| Keywords | COVID-19 ワクチン (vaccination) 抗体価 (antibody titer) 感染 (infection) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 118 |
| End Page | 125 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.118 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.118 |
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2024 Sunada Prize) |
|---|---|
| Author | Kawana, Shinichi| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 95 |
| End Page | 97 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.95 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.95 |
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in General Medical Science (2024 Yuuki Prize) |
|---|---|
| Author | Yumoto, Tetsuya| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 92 |
| End Page | 94 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.92 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.92 |
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in Cancer Research (2024 Hayashibara Prize and Yamada Prize) |
|---|---|
| Author | Takihira, Shota| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 89 |
| End Page | 91 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.89 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.89 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gekko, Haruna| Nomura, Ruri| Kuzuhara, Daiki| Kaneyasu, Masato| Koseki, Genpei| Adhikari, Deepak| Mio, Yasuyuki| Carroll, John| Kono, Tomohiro| Funahashi, Hiroaki| Wakai, Takuya| |
| Published Date | 2025-08-11 |
| Publication Title | eLife |
| Volume | volume13 |
| Publisher | eLife Sciences Publications, Ltd |
| Start Page | RP99936 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024, Gekko, Nomura et al. |
| File Version | publisher |
| PubMed ID | 40788164 |
| DOI | 10.7554/elife.99936 |
| Web of Science KeyUT | 001548098200001 |
| Related Url | isVersionOf https://doi.org/10.7554/elife.99936 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Goto, Hideaki| Yamanaka, Tomoru| Makita, Tomohiro| Iwasa, Yoshiya| Ogura, Takuro| Kagohara, Kyoko| Kumahara, Yasuhiro| Suzuki, Yasuhiro| Matta, Nobuhisa| Aoki, Tatsuto| Mori, Wataru| Haranishi, Kenta| Nakata, Takashi| |
| Keywords | Active submarine fault Tectonic landform Coseismic coastal uplift Noto Peninsula Sea of Japan |
| Published Date | 2026-01 |
| Publication Title | Geomorphology |
| Volume | volume493 |
| Publisher | Elsevier BV |
| Start Page | 110069 |
| ISSN | 0169-555X |
| NCID | AA10686195 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.geomorph.2025.110069 |
| Related Url | isVersionOf https://doi.org/10.1016/j.geomorph.2025.110069 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wakasa, Sachi| Ishiyama, Tatsuya| Hirouchi, Daisuke| Matta, Nobuhisa| Fujita, Natsuko| Echigo, Tomoo| |
| Keywords | Marine terrace Exposure age 10Be Coastal uplift |
| Published Date | 2025-01 |
| Publication Title | Geomorphology |
| Volume | volume468 |
| Publisher | Elsevier BV |
| Start Page | 109497 |
| ISSN | 0169-555X |
| NCID | AA10686195 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.geomorph.2024.109497 |
| Web of Science KeyUT | 001359777100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.geomorph.2024.109497 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Wataru| Asada, Noboru| Ikegawa, Shuntaro| Fujiwara, Hideaki| Kamoi, Chihiro| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Maeda, Yoshinobu| |
| Keywords | chimeric antigen receptor T cell therapy diffuse large B cell lymphoma flow cytometry cytokine release syndrome prolonged cytopenia |
| Published Date | 2024-07-01 |
| Publication Title | Internal Medicine |
| Volume | volume63 |
| Issue | issue13 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 1863 |
| End Page | 1872 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 38945932 |
| DOI | 10.2169/internalmedicine.2556-23 |
| Web of Science KeyUT | 001274095500003 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.2556-23 |