result 49234 件
| JaLCDOI | 10.18926/AMO/52141 |
|---|---|
| FullText URL | 68_1_27.pdf |
| Author | Yoshida, Masao| Ishikawa, Mamoru| Karita, Kanae| Kokaze, Akatsuki| Harada, Matsuko| Take, Shinichiro| Ohno, Hideki| |
| Abstract | To clarify whether high blood pressure (BP) and high body mass index (BMI) are associated with elevated intraocular pressure (IOP), a cross-sectional and longitudinal study was conducted. This epidemiological study analyzed health examination data obtained between 2001 and 2005 from 896 Japanese individuals (aged 32-79 years) who had not undergone any ocular surgery or medical treatment for hypertension, ocular hypertension, or glaucoma. Multiple-regression analysis of our cross-sectional data showed that systolic and diastolic BP (SBP and DBP) and BMI had significant and near-significant positive associations with IOP in men (p＜0.05) and women (p＜0.1). Our longitudinal study from analyses of covariance found that the adjusted mean level of changes in IOP tended to increase with increased levels of SBP, DBP, and BMI in men (p＜0.1). In women also, changes in SBP and BMI tended to be positively related with that of IOP (p＜0.1). The results of this study suggested that BP and BMI were positively associated with IOP in middle-aged and older Japanese. Therefore, management of BP and improvement of obesity might be especially important to Japanese patients with open-angle glaucoma or ocular hypertension as they have a higher incidence of normal-tension glaucoma than Europeans and Americans. |
| Keywords | intraocular pressure blood pressure body mass index epidemiology glaucoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 27 |
| End Page | 34 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553486 |
| Web of Science KeyUT | 000331592800005 |
| JaLCDOI | 10.18926/AMO/52140 |
|---|---|
| FullText URL | 68_1_23.pdf |
| Author | Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro| |
| Abstract | The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM. |
| Keywords | mesothelioma microRNA microRNA-34b/c p53 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 23 |
| End Page | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553485 |
| Web of Science KeyUT | 000331592800004 |
| JaLCDOI | 10.18926/AMO/52139 |
|---|---|
| FullText URL | 68_1_17.pdf |
| Author | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
| Abstract | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
| Keywords | hepatic steatosis genetic polymorphism interferon HCV |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 22 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553484 |
| Web of Science KeyUT | 000331592800003 |
| JaLCDOI | 10.18926/AMO/52138 |
|---|---|
| FullText URL | 68_1_7.pdf |
| Author | Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi| |
| Abstract | Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. |
| Keywords | cell biology immunosuppression stem cells |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553483 |
| Web of Science KeyUT | 000331592800002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52247 |
| JaLCDOI | 10.18926/AMO/52137 |
|---|---|
| FullText URL | 68_1_1.pdf |
| Author | Tanihara, Shinichi| Imatoh, Takuya| Momose, Yoshito| |
| Abstract | Setting public health priorities requires precise estimation of the burden of disease, including disease-specific medical expenditure. Information on multiple and ruled-out diagnoses on health insurance claims (HICs) has been ignored in traditional analyses of disease-specific medical expenditures in Japan. This study reviewed 448 inpatients with at least one diagnosis of sepsis on their HICs, who were insured by corporate health insurance organizations making claims on services provided from April 2006 to March 2007 in Japan. Subjects in whom sepsis-related diagnoses were specified as “ruled-out” were compared with subjects in whom sepsis-related diagnoses were classified as “not-ruled-out” (i.e., subjects in whom sepsis was considered possibly or likely present). Direct medical expenditure, length of stay (LOS), cost per day, cost of antibiotics, and proportion of administered cephalosporin and carbapenems were significantly higher in subjects classified as not-rule-out. When using health insurance claims in Japan, the statistics of medical expenditures and LOS are influenced by procedures performed to rule out a diagnosis, as well as those performed to treat a confirmed diagnosis of sepsis. |
| Keywords | health insurance claims length of stay medical expenditures ruled-out diagnoses sepsis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553482 |
| Web of Science KeyUT | 000331592800001 |
| Author | 杉浦 裕子| 曽我 賢彦| 前田 嘉信| |
|---|---|
| Published Date | 2010-09-01 |
| Publication Title | 造血細胞移植now&future |
| Volume | volume20 |
| Content Type | Article |
| Author | 岡山大学教育学部社会科地理学教室| |
|---|---|
| Published Date | 1982 |
| Publication Title | 岡大教育社会地理巡検シリーズ |
| Volume | volume9 |
| Content Type | Book |
| Author | 岡山大学教育学部社会科地理学教室| |
|---|---|
| Published Date | 1979 |
| Publication Title | 岡大教育社会地理巡検シリーズ |
| Volume | volume8 |
| Content Type | Book |
| Author | 岡山大学教育学部社会科地理学教室| |
|---|---|
| Published Date | 1973 |
| Publication Title | 岡大教育社会地理巡検シリーズ |
| Volume | volume7 |
| Content Type | Book |
| Author | 岡山大学教育学部社会科地理学教室| |
|---|---|
| Published Date | 1971 |
| Publication Title | 岡大教育社会地理巡検シリーズ |
| Volume | volume6 |
| Content Type | Book |
| Author | 岡山大学教育学部社会科地理学教室| |
|---|---|
| Published Date | 1965 |
| Publication Title | 岡大教育社会地理巡検シリーズ |
| Volume | volume4 |
| Content Type | Book |
| Author | 岡山大学農学部| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Others |
| Author | 岡山大学農学部| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Others |
| Author | 岡山大学農学部| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Others |
| Author | Tanaka, Yoshiyuki| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Noutoshi, Yoshiteru| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Monden, Yuki| Takai, Takeru| Tahara, Makoto| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Yoshida, Yuichi| Ohmori, Toshimasa| Goto, Tanjuro| Tanaka, Yoshiyuki| Murakami, Kenji| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Nakai, Ryuichiro| Fujino, Shihoko| Utsumi, Tomohiro| Tamura, Takashi| Kusakabea, Hitoshi| Inagaki, Kenji| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
| Author | Md. Akhtaruzzaman| Maeda, Megumi| Kitagawa, Keiko| Takagi, Shigeaki| Kimura, Yoshinobu| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
