オリゴペプチド経腸栄養剤の使用経験

窒素源としてdi-，tri－peptideを含有した経腸栄養剤を外科患者に使用した。．この新しい経腸栄養剤は卵白を加水分解したもので，70％がoligopeptideであり，アミノ酸も10％含まれる。糖質はデキストリンで，脂肪の含有量は少なく浸透圧はエレメンタルダイエット（ED）より低い。この製剤を安定期および術後に使用した。アルブミン，rapid turnover proteinの回復がみられ，臓器蛋白の合成が得られた。術後例では3メチルヒスチジンの排泄量は減少せず，異化反応は抑制されなかった。投与量の不足が一つの原因と思われる。副作用の下痢はほとんどみられず，栄養改善効果もあり，有用性が認められた。

The clinical usefulness of new enteral formula which is contained di-and tri-peptides as a nitrogen source was evaluated in surgical patients. The enteral nutrition was introduced to stable patients who could not take food orally and postoperative ones who were undertaken upper GI surgery. Adverse effects such as diarrhea or abdomonal distension were not observed. V isceral proteins were improved after administration of this regimen and nutritional status was maintained in all patients. However, high urinary excretion of 3methylhistidine continued in great extent during postopertive period and breakdown of skeletal muscle was not prevented by this nutritional therapy. This might be due to insufficient intake of energy and nitrogen. This new product for enteral nutrition would be safe and useful as enteral nutrition.