クエン酸鉄投与及び純酸素負荷マウスのグアニジノ化合物の変動に関する研究

The guanidino compounds in various mouse organs after i.p. administration of ferric citrate(Fe) and after inhalation of pure oxygen(O(2)) were studied. Guanidinoacetic acid and N-acetylarginine levels were markedly higher in the kidney, and they decreased after administration of Fe or inhalation of O(2). Creatinine decreased in the liver after administration of Fe, and it decreased in the liver and muscle after inhalation of O(2). γ-Guanidinobutyric acid level was significantly higher in the normal liver, but decreased after administration of Fe or inhalation of O(2). Arginine(Arg) increased in the kidney and muscle after administration of Fe, while it decreased in the liver. Arg decreased in the kidney and the muscle after inhalation of O(2). Methylguanidine(MG) increased in the brain after administration of Fe or inhalation of O(2). However, MG decreased in the liver after administration of Fe, and also decreased in the liver, kidney and muscle after inhalation of O(2). MG increased only in the brain. This finding suggested that the reactive oxygen species(O(2)(-), H(2)O(2), ・OH) were most effective there, because oxygen consumpution in the brain was much more than in the other organs.

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