result 749 件
| JaLCDOI | 10.18926/AMO/64372 |
|---|---|
| FullText URL | 77_1_117.pdf |
| Author | Obara, Takafumi| Yumoto, Tetsuya| Aoshima, Kenji| Tsukahara, Kohei| Naito, Hiromichi| Nakao, Atsunori| |
| Abstract | A 38-year-old primipara Japanese woman suffered cardiac arrest due to a pulmonary thromboembolism 1 day after undergoing a cesarean section. Extracorporeal cardiopulmonary resuscitation was initiated and extracorporeal membrane oxygenation support was needed for 24 h. Despite intensive care, the patient was diagnosed with brain death on day 6. With the family’s consent, comprehensive end-of-life care including organ donation was discussed based on our hospital’s policy. The family decided to donate her organs. Specific training and education are required for emergency physicians to optimize the process of incorporating organ donation into end-of-life care while respecting the patient’s and family’s wishes. |
| Keywords | brain death end-of-life extracorporeal cardiopulmonary resuscitation organ donation potential organ donor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 117 |
| End Page | 120 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849156 |
| Web of Science KeyUT | 000953005500003 |
| JaLCDOI | 10.18926/AMO/64356 |
|---|---|
| FullText URL | 77_1_11.pdf |
| Author | Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| Abstract | The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction. |
| Keywords | breast reconstruction mastectomy brassiere professional bra fitter |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 11 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849141 |
| Web of Science KeyUT | 000953663800002 |
| JaLCDOI | 10.18926/AMO/64355 |
|---|---|
| FullText URL | 77_1_1.pdf |
| Author | Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio| |
| Abstract | Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA. |
| Keywords | antimicrobial resistance clindamycin erm D-zone test inducible MLSB |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 9 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849140 |
| Web of Science KeyUT | 000953663800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Noro, Yusuke| Li, Ruixiang| Matsui, Teppei| Jimura, Koji| |
| Keywords | resting-state fMRI task fMRI temporal dynamics individual difference Human Connectome Project |
| Published Date | 2023-01-12 |
| Publication Title | Frontiers In Neuroinformatics |
| Volume | volume16 |
| Publisher | Frontiers Media |
| Start Page | 960607 |
| ISSN | 1662-5196 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Noro, Li, Matsui and Jimura. |
| File Version | publisher |
| PubMed ID | 36713290 |
| DOI | 10.3389/fninf.2022.960607 |
| Web of Science KeyUT | 000918473200001 |
| Related Url | isVersionOf https://doi.org/10.3389/fninf.2022.960607 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morón-López, Jesús| Vergara, Karen| Sato, Masanao| Gajardo, Gonzalo| Ueki, Shoko| |
| Published Date | 2022-08-18 |
| Publication Title | PLOS ONE |
| Volume | volume17 |
| Issue | issue8 |
| Publisher | Public Library Science |
| Start Page | e0273330 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Morón-López et al. |
| File Version | publisher |
| PubMed ID | 35980990 |
| DOI | 10.1371/journal.pone.0273330 |
| Web of Science KeyUT | 000892314200084 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0273330 |
| Title Alternative | The beginning date of wet rice cultivation at the of Okayama University site: Tree ring oxygen isotope dating and radiocarbon 14 age of weirs from the mid-I stage of the Yayoi period |
|---|---|
| JaLCDOI | 10.18926/64199 |
| FullText URL | jdc_002_018.pdf |
| Author | FUJIO, Shinichiro| SAKAMOTO, Minoru| SANO, Masaki| |
| Abstract | This article clarifies the date when paddy field rice cultivation began at the archaeological site located within the Okayama University campus. The analysis used tree ring oxygen isotope dating and radiocarbon dating. When the oxygen isotope ratios of wood used in paddy weirs detected in the 23rd excavation season were examined, peaks could be seen in two places: in the 10th century BC and the 6th century BC. Since the weir was accompanied by mid-I stage Yayoi pottery, which was dated to the 6th century BC using radiocarbon dating, tree ring dating determined that the weir was made from wood cut down soon after 540 BC. Therefore, it was reaffirmed that one of the points of the mid-I stage can be dated to the middle of the 6th century BC. Next is the age of the early-I stage, when paddy field rice cultivation began on the Okayama Plain. In the Tsuruba area of the Nishikawazu archaeological site in Shimane Prefecture, where paddy field rice cultivation is thought to have begun at the same time as on the Okayama Plain, tree ring oxygen isotope dating of wood accompanied by early-I stage pottery has been reported. The date of 649 BC date means that one of the earliest stages of the early-I period dates to the middle of the 7th century BC. Therefore, we reaffirmed the view that paddy rice cultivation in the Chugoku region, such as Okayama and Shimane, began in the 7th century BC. It also became clear that the beginning of paddy field rice cultivation in the Chugoku region occurred at a time when the climate that had been the base of cold in the 10th century BC gradually warmed and the relatively humid climate began to turn to arid. |
| Keywords | 土器付着炭化物：carbides adhering to pottery 酸素同位体比年輪年代法：tree ring oxygen isotope dating 炭素14年代法：radiocarbon dating 岡山大学構内遺跡：the Okayama University site 弥生前期：the early Yayoi period 水田稲作：wet rice cultivation 堰：weirs |
| Amo Type | 研究ノート (Research note) |
| Publication Title | Dynamics of Civilizations |
| Published Date | 2023-03-25 |
| Volume | volume2 |
| Publisher | 岡山大学文明動態学研究所 |
| Start Page | 18 |
| End Page | 31 |
| ISSN | 2436-8326 |
| Content Type | Journal Article |
| language | Japanese |
| Copyright Holders | © 2023 by RIDC |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tominaga, Yuki| Sakurai, Yusuke| Miyata, Junya| Harada, Shuichi| Akagi, Takashi| Oita, Masataka| |
| Keywords | commissioning lateral penumbra multi-leaf collimator pencil beam scanning proton therapy |
| Published Date | 2022-11-24 |
| Publication Title | Journal Of Applied Clinical Medical Physics |
| Volume | volume23 |
| Publisher | Wiley |
| Start Page | e13817 |
| ISSN | 1526-9914 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 36420959 |
| DOI | 10.1002/acm2.13817 |
| Web of Science KeyUT | 000889306500001 |
| Related Url | isVersionOf https://doi.org/10.1002/acm2.13817 |
| Title Alternative | Idiopathic first bite syndrome improved by Rikkosan : A case report |
|---|---|
| FullText URL | fulltext20221125-1.pdf |
| Author | Sato, Asuka| Ishihara, Hisashi| Kariya, Akifumi| Akisada, Naoki| Fuji, Sayaka| Akagi, Seiko| Takeuchi, Ayako| |
| Keywords | First bite syndrome, 立効散 耳下腺部痛 顔面痛 糖尿病性神経障害 |
| Published Date | 2021-11-20 |
| Publication Title | jibi to rinsho |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | 耳鼻と臨床会 |
| Start Page | 402 |
| End Page | 406 |
| ISSN | 2185-1034 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 耳鼻と臨床会 |
| File Version | publisher |
| DOI | 10.11334/jibi.67.6_402 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Cong, Yingnan| Zhu, Chen| Hou, Yufei| Tian, Shuairu| Cai, Xiaojing| |
| Keywords | ESG investment carbon emission carbon productivity regional effect green transition |
| Published Date | 2022-10-12 |
| Publication Title | Frontiers In Environmental Science |
| Volume | volume10 |
| Publisher | Frontiers Media |
| Start Page | 977049 |
| ISSN | 2296-665X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Cong, Zhu, Hou, Tian and Cai. |
| File Version | publisher |
| DOI | 10.3389/fenvs.2022.977049 |
| Web of Science KeyUT | 000876485500001 |
| Related Url | isVersionOf https://doi.org/10.3389/fenvs.2022.977049 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Toyama, Naoki| Ekuni, Daisuke| Yokoi, Aya| Fukuhara, Daiki| Islam, Md Monirul| Sawada, Nanami| Nakashima, Yukiho| Nakahara, Momoko| Sumita, Ichiro| Morita, Manabu| |
| Keywords | oral microbiome elderly people diversity bacteria non-severe periodontal condition |
| Published Date | 2022-10-06 |
| Publication Title | Frontiers In Cellular And Infection Microbiology |
| Volume | volume12 |
| Publisher | Frontiers Media SA |
| Start Page | 957890 |
| ISSN | 2235-2988 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Toyama, Ekuni, Yokoi, Fukuhara, Islam, Sawada, Nakashima, Nakahara, Sumita and Morita. |
| File Version | publisher |
| PubMed ID | 36275030 |
| DOI | 10.3389/fcimb.2022.957890 |
| Web of Science KeyUT | 000874245900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcimb.2022.957890 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tram, Vo Ngoc Quynh| Somura, Hiroaki| Moroizumi, Toshitsugu| Maeda, Morihiro| |
| Keywords | Land-use policies Land-use changes Agricultural practices Water resources management Hilly areas |
| Published Date | 2022-12 |
| Publication Title | Journal Of Hydrology-Regional Studies |
| Volume | volume44 |
| Publisher | Elsevier |
| Start Page | 101225 |
| ISSN | 2214-5818 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.ejrh.2022.101225 |
| Web of Science KeyUT | 000873972800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejrh.2022.101225 |
| FullText URL | fulltext20221026-3.pdf |
|---|---|
| Author | Honda, Yasuko| |
| Keywords | Community renewable energy rural community local initiative Japan Agricultural Cooperatives energy cooperative |
| Note | Journal of Asian Rural Studies, 2021, 5(1): 63-77| |
| Published Date | 2021-3-26 |
| Publication Title | Journal of Asian Rural Studies |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Hasanuddin University and Asian Rural Sociology Association |
| Start Page | 63 |
| End Page | 77 |
| ISSN | 2548-3269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.20956/jars.v5i1.2656 |
| Related Url | isVersionOf https://doi.org/10.20956/jars.v5i1.2656 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishimura, Takeshi| Suga, Masafumi| Nakao, Atsunori| Ishihara, Satoshi| Naito, Hiromichi| |
| Keywords | AAM Endotracheal intubation JTDB supraglottic airway traumatic cardiac arrest |
| Published Date | 2022-09-16 |
| Publication Title | Acute Medicine & Surgery |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e786 |
| ISSN | 2052-8817 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 36176323 |
| DOI | 10.1002/ams2.786 |
| Web of Science KeyUT | 000854253100001 |
| Related Url | isVersionOf https://doi.org/10.1002/ams2.786 |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| FullText URL | 76_4_479.pdf |
| Author | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| Keywords | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63896 |
|---|---|
| FullText URL | 76_4_415.pdf |
| Author | Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan| |
| Abstract | Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction. |
| Keywords | 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123156 |
| Web of Science KeyUT | 000882167300007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ahmed, Feroz| Shimizu, Masashi| Wang, Jin| Sakai, Kenji| Kiwa, Toshihiko| |
| Keywords | microfluidics fluid dynamics 3D simulation ReLU dense layers Leaky ReLU swish activation functions deep learning model |
| Published Date | 2022-08-20 |
| Publication Title | Micromachines |
| Volume | volume13 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1352 |
| ISSN | 2072-666X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36014274 |
| DOI | 10.3390/mi13081352 |
| Web of Science KeyUT | 000845405500001 |
| Related Url | isVersionOf https://doi.org/10.3390/mi13081352 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Jiang, Jiaming| Zhao, Yu| Feng, Junshi| |
| Keywords | collaborative networks technology transfer China university-firm collaboration social network analysis economic policy economic statistics |
| Published Date | 2022-08-04 |
| Publication Title | Sustainability |
| Volume | volume14 |
| Issue | issue15 |
| Publisher | MDPI |
| Start Page | 9582 |
| ISSN | 2071-1050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| DOI | 10.3390/su14159582 |
| Web of Science KeyUT | 000839222400001 |
| Related Url | isVersionOf https://doi.org/10.3390/su14159582 |
| JaLCDOI | 10.18926/AMO/63748 |
|---|---|
| FullText URL | 76_3_355.pdf |
| Author | Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi| |
| Abstract | An 89-year-old male came to the hospital with a complaint of abdominal distension. Abdominal computed tomography showed wall thickening in the descending colon and marked dilatation of the proximal colon, and lower gastrointestinal endoscopy demonstrated a stenosis in the descending colon. Although a biopsy from the stenotic lesion showed calcified eggs of Schistosoma japonicum with no malignant findings, we suspected malignant involvement, so we performed a descending colectomy with regional lymph node dissection. Pathological examination revealed a moderately differentiated adenocarcinoma. The colon cancer was diagnosed as pT4bN0M0, Stage IIc. The patient’s history as a resident of one of the formerly endemic areas of Japan suggests that he may have carried S. japonicum for a long time, and that it may have contributed to carcinogenesis. |
| Keywords | Schistosoma japonicum descending colon cancer carcinogenesis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 355 |
| End Page | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790369 |
| Web of Science KeyUT | 000823568300017 |
| JaLCDOI | 10.18926/AMO/63739 |
|---|---|
| FullText URL | 76_3_297.pdf |
| Author | Kuroda, Masahiro| Konishi, Kohei| Sugimoto, Kohei| Yoshimura, Yuuki| Hamada, Kentaro| Khasawnehc, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kamizaki, Ryo| Kurozumi, Akira| Matsushita, Toshi| Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research. |
| Keywords | fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 297 |
| End Page | 305 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790360 |
| Web of Science KeyUT | 000823568300009 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| FullText URL | 76_3_255.pdf |
| Author | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| Abstract | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| Keywords | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
