start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=102570 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Epidemiology and clinical features of patients with tick bites in the Japanese spotted fever-endemic zone en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose: This study aimed to clarify the epidemiology and clinical features of tick bites in a Japanese spotted fever (JSF)-endemic area.
Method: The clinical records of patients with tick bites were retrospectively reviewed based on a survey conducted at Numakuma Hospital, Fukuyama City, Hiroshima, Japan, from 2016 to 2023. Data on basic characteristics, visit dates, residential address, exposure activities, tick-bite sites, and prophylactic antimicrobial prescriptions for each patient with tick bites were collected at the JSF hotspot hospital.
Results: A total of 443 patients with tick bites visited the hospital, of which data on 305 cases (68.8 %) were reviewed. The median age of these patients was 71 years, with a higher proportion of women (63.0 %). One-third of the patients had a preceding history of working in fields, whereas two-thirds had entered mountains or agricultural fields. Nearly 90 % of the patients visited the hospital from April to August, and the most common bite sites were the lower extremities (45.1 %). Most patients (76.1 %) resided in the southern area of Numakuma Hospital. Nearly all patients were prescribed prophylactic antibiotics (minocycline in 87.8 % of cases), and none subsequently developed JSF.
Conclusion: Continued surveillance of patients with tick bites is warranted to better understand changes in the clinical impact of tick-borne diseases. en-copyright= kn-copyright= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SumidaTakaomi en-aut-sei=Sumida en-aut-mei=Takaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawamataOsamu en-aut-sei=Kawamata en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HidaniYoshimi en-aut-sei=Hidani en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Numakuma Hospital kn-affil= affil-num=3 en-affil=Numakuma Hospital kn-affil= affil-num=4 en-affil=Numakuma Hospital kn-affil= affil-num=5 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=Global warming kn-keyword=Global warming en-keyword=Japanese spotted fever kn-keyword=Japanese spotted fever en-keyword=Tick bite kn-keyword=Tick bite en-keyword=Tick-borne diseases kn-keyword=Tick-borne diseases END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=6 article-no= start-page=439 end-page=447 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk Factors for Gangrenous Cholecystitis and the Outcomes of Early Cholecystectomy: A Retrospective Study of a Single-Center City General Hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken. en-copyright= kn-copyright= en-aut-name=YamashitaMampei en-aut-sei=Yamashita en-aut-mei=Mampei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakayuki en-aut-sei=Tanaka en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SumidaYorihisa en-aut-sei=Sumida en-aut-mei=Yorihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamazakiShoto en-aut-sei=Yamazaki en-aut-mei=Shoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaraYuki en-aut-sei=Hara en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukudaAkiko en-aut-sei=Fukuda en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HisanagaMakoto en-aut-sei=Hisanaga en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WakataKoki en-aut-sei=Wakata en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMasato en-aut-sei=Araki en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=EguchiSusumu en-aut-sei=Eguchi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=2 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=3 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=4 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=5 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=6 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=7 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=8 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=9 en-affil=Department of Surgery, Sasebo City General Hospital kn-affil= affil-num=10 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= en-keyword=gangrenous kn-keyword=gangrenous en-keyword=cholecystitis kn-keyword=cholecystitis en-keyword=acute cholecystitis kn-keyword=acute cholecystitis en-keyword=laparoscopic cholecystectomy kn-keyword=laparoscopic cholecystectomy END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=12 article-no= start-page=1324 end-page=1326 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Detailed regimens for the prolonged β-lactam infusion therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=A recent systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of prolonged versus intermittent β-lactam infusion in adult sepsis patients. The findings revealed a significant decrease in all-cause mortality and marked clinical success in the prolonged infusion group. Unfortunately, however, the manuscript lacked data and discussion for the specific regimens of prolonged β-lactam infusion defined in the included 15 RCT studies, which are herein additionally provided. Excluding one RCT, all protocols adopted a continuous infusion for the prolonged treatment. Except for three RCTs, dosages and timings of bolus injection were clearly defined. The total daily antibiotic dose for the continuous therapy was equivalent to those recommended for intermittent therapy. We believe this supplementary data aids clinicians in providing prolonged β-lactam infusions, contributing to enhanced treatment outcomes for patients suffering from severe sepsis or septic shock. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=Sepsis kn-keyword=Sepsis en-keyword=Continuous infusion kn-keyword=Continuous infusion en-keyword=Prolonged infusion kn-keyword=Prolonged infusion en-keyword=Pharmacokinetics kn-keyword=Pharmacokinetics END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=5 article-no= start-page=371 end-page=376 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract=Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control. en-copyright= kn-copyright= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyoshiMakoto en-aut-sei=Miyoshi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=I Putu Bayu Mayura en-aut-sei=I Putu Bayu Mayura en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsujiShuma en-aut-sei=Tsuji en-aut-mei=Shuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsushitaOsamu en-aut-sei=Matsushita en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Clinical Microbiology, Faculty of Medicine, Udayana University kn-affil= affil-num=4 en-affil=Department of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=carbapenemase-producing enterobacterales kn-keyword=carbapenemase-producing enterobacterales en-keyword=carbapenemase-resistant enterobacterales kn-keyword=carbapenemase-resistant enterobacterales en-keyword=Silent pandemic kn-keyword=Silent pandemic en-keyword=whole genome sequence kn-keyword=whole genome sequence END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=3 article-no= start-page=205 end-page=213 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Thoughts on and Proposal for the Education, Training, and Recruitment of Infectious Disease Specialists en-subtitle= kn-subtitle= en-abstract= kn-abstract=The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=emerging infectious diseases kn-keyword=emerging infectious diseases en-keyword=infection prevention and control kn-keyword=infection prevention and control en-keyword=medical education kn-keyword=medical education en-keyword=silent pandemic kn-keyword=silent pandemic END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=95 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response en-subtitle= kn-subtitle= en-abstract= kn-abstract=The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. en-copyright= kn-copyright= en-aut-name=ItanoJunko en-aut-sei=Itano en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= en-keyword=neuropeptide y kn-keyword=neuropeptide y en-keyword=Y1 receptor kn-keyword=Y1 receptor en-keyword=airway immune response kn-keyword=airway immune response en-keyword=bronchial epithelial cells kn-keyword=bronchial epithelial cells en-keyword=respiratory disease kn-keyword=respiratory disease END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=12 article-no= start-page=1739 end-page=1742 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230615 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antimicrobials in the Hospital Are Unevenly Discontinued on Weekdays en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective　Amid the global spread of antimicrobial resistance, antimicrobial stewardship should be further promoted in the clinical setting. Our previous study suggested an intra-week disproportion of discontinuation of broad-spectrum antibiotics. We therefore explored the generalization of this prescription trend by investi-gating the use of all intravenous antibiotics.
Methods　A retrospective, observational study.
Patients　Between January 1, 2018, and December 31, 2020, we collected data on the initiation and discon-tinuation of intravenous antimicrobials on each day of the week and on days after holidays at Okayama Uni-versity Hospital, Japan. We compared the monthly antimicrobial prescription initiation and discontinuation using the Kruskal-Wallis test and Mann-Whitney U-test with Bonferroni correction as a post-hoc procedure.
Results　Data from 15,293 hospitalized cases were analyzed. The initiation of antimicrobials differed slightly among days of the week, although this trend was clinically insignificant. Compared with the initia-tions, antimicrobial discontinuations were disproportionately biased among the weekdays, tending to occur on Mondays (p<0.001) about twice as often as on other days. Similarly, antimicrobials were unevenly discontin-ued on the day after holidays compared to other days (p<0.001), with an approximately 2-fold difference. The use of antimicrobials in the hospital was thus unequally terminated on weekdays.
Conclusion　To further promote antimicrobial stewardship, clinicians should be aware of the influence of behavioral, environmental, and social factors on antimicrobial prescription, which is seemingly beyond medi-cal indications. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UnoMika en-aut-sei=Uno en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HigashionnaTsukasa en-aut-sei=Higashionna en-aut-mei=Tsukasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HondaHiroyuki en-aut-sei=Honda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=antimicrobial stewardship kn-keyword=antimicrobial stewardship en-keyword=antibiotics kn-keyword=antibiotics en-keyword=weekdays kn-keyword=weekdays en-keyword=weekends kn-keyword=weekends END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=3 article-no= start-page=255 end-page=262 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Prevalence of Antimicrobial Resistance in Okayama from a National Database between 2018 and 2021 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Antimicrobial resistance is an emerging global threat that must be addressed using a multidisciplinary approach. This study aimed to raise awareness of high-level antimicrobial-resistant (AMR) pathogens in Japan by comparing their recent prevalences among prefectures, particularly Okayama. Data for the isolation proportions of meropenem-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae, and levofloxacin-resistant E. coli and K. pneumoniae were collected from the Japan Nosocomial Infections Surveillance, a national database sponsored by the Japanese Ministry of Health, Labour, and Welfare, between 2018 and 2021. The average isolated proportions of the seven AMR pathogens were higher in Okayama compared to other prefectures: the worst (19.9%) was meropenem-resistant P. aeruginosa, the sixth worst (57.2%) was methicillin-resistant S. aureus, the eighth worst (3.3%) was vancomycin-resistant E. faecium, the second (37.8%) and fifth worst (17.6%) were cefotaxime-resistant E. coli and K. pneumoniae, respectively, and the fourth (49.9%) and third worst (8.7%) were levofloxacin-resistant E. coli and K. pneumoniae, respectively. Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama. en-copyright= kn-copyright= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UdaKazuhiro en-aut-sei=Uda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=antimicrobial stewardship kn-keyword=antimicrobial stewardship en-keyword=epidemiology kn-keyword=epidemiology en-keyword=infection prevention and control kn-keyword=infection prevention and control en-keyword=Japan Nosocomial Infections Surveillance kn-keyword=Japan Nosocomial Infections Surveillance END start-ver=1.4 cd-journal=joma no-vol=134 cd-vols= no-issue=3 article-no= start-page=166 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of duodenal diverticulitis in a patient receiving tocilizumab for rheumatoid arthritis kn-title=トシリズマブ投与中に十二指腸憩室炎を認めた１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A Japanese woman was diagnosed with rheumatoid arthritis at the age of 41. At the age of 56, her rheumatoid arthritis worsened and a subcutaneous injection of tocilizumab and oral prednisolone was administered, which led to an improvement of arthritis. At the age of 57, right lower abdominal pain and vomiting suddenly appeared. Abdominal computed tomography showed a parapapillary diverticulum in the descending duodenum. The diverticulum was filled with residue, and an inflammation of the surrounding adipose tissue was observed; no free air was found. The patient was diagnosed with duodenal diverticulitis and treated with antibiotics, which resulted in an uneventful recovery. The maximum value of CRP was 1.88㎎/dL on the third day of hospitalization. Esophagogastroduodenoscopy performed on the 8th day of hospitalization revealed a parapapillary diverticulum with adhesion of pus and redness of the mucosa at the opening of the diverticulum, consistent with diverticulitis. This case highlights that diverticulitis in infrequent areas such as the duodenum may occur in patients who are treated with tocilizumab. In addition, inflammation of diverticulitis may be underestimated because abnormal laboratory values such as those induced by inflammatory reactions are less likely to occur during tocilizumab treatment. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=BabaYuki en-aut-sei=Baba en-aut-mei=Yuki kn-aut-name=馬場雄己 kn-aut-sei=馬場 kn-aut-mei=雄己 aut-affil-num=2 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=3 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Department of Internal Medicine, Mitoyo General Hospital kn-affil=三豊総合病院　内科 affil-num=3 en-affil=Department of Practical Gastrointestinal Endoscopy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学学術研究院医歯薬学域　実践地域内視鏡学講座 affil-num=4 en-affil=Professor Emeritus, Okayama University kn-affil=岡山大学　名誉教授 en-keyword=トシリズマブ（tocilizumab） kn-keyword=トシリズマブ（tocilizumab） en-keyword=十二指腸憩室（duodenal diverticulum） kn-keyword=十二指腸憩室（duodenal diverticulum） en-keyword=憩室炎（diverticulitis） kn-keyword=憩室炎（diverticulitis） END start-ver=1.4 cd-journal=joma no-vol=2022 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Surgical site infections in thyroid and parathyroid surgery in Japan: An analysis of the Japan Nosocomial Infections Surveillance database from 2013 to 2020 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Surgical site infections (SSIs) after thyroid surgery are rare complications, with incidence rates of 0.3%-1.6%. Using a Japanese database, we conducted exploratory analyses on the incidence of SSIs, investigated the incidence of SSIs by the National Nosocomial Infections Surveillance risk index, and identified the causative bacteria of SSIs. SSIs occurred in 50 (0.7%) of 7388 thyroid surgery cases. Risk index-0 patients had the lowest incidence rate of SSIs (0.41%). The incidence of SSIs in risk index-1 patients was 3.05 times the incidence of SSIs in risk index-0 patients. The rate of SSI occurrence for risk index-2 patients was 4.22 times the rate of SSI occurrence for risk index-0 patients. Thirty-one bacterial species were identified as the cause of SSIs in thyroid surgery cases, of which 12 (38.7%) SSIs were caused by Staphylococcus aureus and Staphylococcus epidermidis. Of the nine SSIs caused by Staphylococcus aureus, 55.6% (five cases) were attributed to methicillin-resistant Staphylococcus aureus. Therefore, routine prophylactic antibiotic administration should be avoided, while the target for administration should be narrowed, according to the SSI risk. Administration of prophylactic antibiotics, such as 2 g piperacillin or 1 g cefazolin, is considered appropriate. en-copyright= kn-copyright= en-aut-name=IwataniTsuguo en-aut-sei=Iwatani en-aut-mei=Tsuguo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoShinya en-aut-sei=Saito en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=parathyroid surgery kn-keyword=parathyroid surgery en-keyword=prophylactic antibiotic kn-keyword=prophylactic antibiotic en-keyword=risk factor kn-keyword=risk factor en-keyword=surgical site infection kn-keyword=surgical site infection en-keyword=thyroid surgery kn-keyword=thyroid surgery END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=7 article-no= start-page=978 end-page=981 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Persistent methicillin-resistant Staphylococcus aureus bacteremia in an adult patient with Netherton's syndrome: A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Netherton's syndrome, a rare congenital disorder, is clinically characterized by chronic dermatologic disorders such as ichthyosiform erythroderma and ichthyosis linearis circumflexa. Curable treatment is yet to be established, and corticosteroid ointment is required to maintain good dermatological condition. Because of the permanent skin barrier impairment, patients with Netherton's syndrome are considered to be vulnerable to cutaneous infections. However, its clinical characteristics are yet to be elucidated due to the limited number of reported cases. Herein, we describe the clinical course of a patient who developed persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. A 19-year-old Japanese woman who had been diagnosed with Netherton's syndrome in her infancy and had been applying topical corticosteroid agents all over her body since her then, was referred to our hospital because of persistent MRSA bacteremia and secondary adrenal insufficiency. The patient was diagnosed with a central line-associated bloodstream infection and was appropriately treated with antibiotics and corticosteroid therapies. We assume that the damaged skin barrier due to the congenital dermatological disorder causes a disruption in the normal bacterial flora of the skin, leading to the invasion of harmful bacteria, such as S. aureus. In addition, internal (humoral immunodeficiency by decreased antibody against bacterial polysaccharide antigens) and external (prolonged and systemic use of corticosteroid ointment) factors bring about an immunodeficiency state in such patients. We highlight that in the absence of radical treatment, clinicians need to recognize that patients with Netherton's syndrome are vulnerable to bacterial infections owing to the mixture of immunosuppressive factors. en-copyright= kn-copyright= en-aut-name=TakahashiMisa en-aut-sei=Takahashi en-aut-mei=Misa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaShuichi en-aut-sei=Tanaka en-aut-mei=Shuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoKoichiro en-aut-sei=Yamamoto en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HondaHiroyuki en-aut-sei=Honda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HasegawaKou en-aut-sei=Hasegawa en-aut-mei=Kou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=2 article-no= start-page=112 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lemierre's syndrome following peritonsillar abscess : A case report kn-title=扁桃周囲膿瘍からレミエール症候群を来した 1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lemierre's syndrome is a disorder in which bacterial infection of the head and neck region leads to thrombosis of the internal jugular vein ; left untreated, this condition can also result in metastatic infections in the lungs and joints as well as bacterial sepsis. An early diagnosis and treatment are important for preventing these pathologic outcomes. We herein report the case of a 30-year-old male with internal jugular vein thrombosis secondary to a peritonsillar abscess accompanied by septic emboli in the lung. The criteria proposed by Yamamoto and Sugiura et al. were used to facilitate a rapid diagnosis of his condition prior to obtaining results from blood cultures. While Lemierre's syndrome is a fairly uncommon diagnosis at this time, its incidence has been increasing given the current pressure to limit the use of antibiotics. Antimicrobial use is currently restricted in Japan due to efforts designed to curb the emergence of drug resistance; as such, we may begin to see more cases of this disease. Although rare, some patients with infection of the head and neck region do develop Lemierre's syndrome ; as such, frequent follow-up of all cases of acute pharyngitis is necessary, notably for those patients not treated with antimicrobial agents. en-copyright= kn-copyright= en-aut-name=KAJIHARASohei en-aut-sei=KAJIHARA en-aut-mei=Sohei kn-aut-name=梶原壮平 kn-aut-sei=梶原 kn-aut-mei=壮平 aut-affil-num=1 ORCID= en-aut-name=ISHIHARAHisashi en-aut-sei=ISHIHARA en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name=KARIYAAkifumi en-aut-sei=KARIYA en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=3 ORCID= en-aut-name=AKISADANaoki en-aut-sei=AKISADA en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=SHIGEHARAAkiko en-aut-sei=SHIGEHARA en-aut-mei=Akiko kn-aut-name=茂原暁子 kn-aut-sei=茂原 kn-aut-mei=暁子 aut-affil-num=5 ORCID= en-aut-name=SATOAki en-aut-sei=SATO en-aut-mei=Aki kn-aut-name=佐藤晶 kn-aut-sei=佐藤 kn-aut-mei=晶 aut-affil-num=6 ORCID= en-aut-name=HAMADAKoji en-aut-sei=HAMADA en-aut-mei=Koji kn-aut-name=濵田浩司 kn-aut-sei=濵田 kn-aut-mei=浩司 aut-affil-num=7 ORCID= en-aut-name=AKAGIYusuke en-aut-sei=AKAGI en-aut-mei=Yusuke kn-aut-name=赤木祐介 kn-aut-sei=赤木 kn-aut-mei=祐介 aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=2 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=4 en-affil=Department of Head and Neck Surgery, Shikoku Cancer Center kn-affil=国立病院機構四国がんセンター頭頸科 affil-num=5 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=6 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=7 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=8 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 en-keyword= Lemierre's syndrome kn-keyword= Lemierre's syndrome en-keyword=Fusobacterium necrophorum kn-keyword=Fusobacterium necrophorum en-keyword=Antimicrobial Resistance kn-keyword=Antimicrobial Resistance en-keyword=扁桃周囲膿瘍 kn-keyword=扁桃周囲膿瘍 en-keyword=耳鼻咽喉科救急 kn-keyword=耳鼻咽喉科救急 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=2 article-no= start-page=104 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Anti-Glomerular Basement Membrane Nephritis Potentially Induced by Nebulized Tobramycin Inhalation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: To describe a case of anti-glomerular basement membrane (GBM) nephritis that occurred shortly after initiation of nebulised tobramycin (TOB) therapy using intravenous solution, suggesting an association with the inhalation therapy and the disease onset.
Background: With the emergence of antimicrobial resistance, clinical importance of aminoglycosides that usually remain susceptibility against gram-negative organisms is increasingly acknowledged. Despite the growing number of evidence supporting the effectiveness of aminoglycoside inhalation therapy for respiratory tract infections, its clinical application has yet to be widely approved by Japanese health insurance.
Case presentation: A 79-year-old Japanese woman had developed amyotrophic lateral sclerosis and experienced recurrent pneumonia mainly caused by Pseudomonas aeruginosa, which required monthly treatments with broad-spectrum antibiotics. Due to the limited approval, we had no choice but to use intravenous TOB solution for inhalation therapy as an off-label use under an endorsement of the Institutional Review Board of the hospital. Although the repeated pneumonia subsided, the patient subsequently needed immunosuppressive therapy along with plasma exchanges for the treatment of anti-GBM nephritis.
Conclusion: Although this off-label use of intravenous solutions is common in both clinical and research purposes, our case raised an issue that its safety needs to be re-evaluated. en-copyright= kn-copyright= en-aut-name=InoueChie en-aut-sei=Inoue en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Internal Medicine, Marugame, Medical Center kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page=20784 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study en-subtitle= kn-subtitle= en-abstract= kn-abstract=To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future. en-copyright= kn-copyright= en-aut-name=HondaHiroyuki en-aut-sei=Honda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HigashionnaTsukasa en-aut-sei=Higashionna en-aut-mei=Tsukasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HarukiYuto en-aut-sei=Haruki en-aut-mei=Yuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HarukiMai en-aut-sei=Haruki en-aut-mei=Mai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KajitaShiho en-aut-sei=Kajita en-aut-mei=Shiho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MukudaKengo en-aut-sei=Mukuda en-aut-mei=Kengo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YokoyamaYuji en-aut-sei=Yokoyama en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakanoYasuhiro en-aut-sei=Nakano en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OgawaHiroko en-aut-sei=Ogawa en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MorimotoYasuyo en-aut-sei=Morimoto en-aut-mei=Yasuyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KandaSetsuko en-aut-sei=Kanda en-aut-mei=Setsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MugurumaHitomi en-aut-sei=Muguruma en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= affil-num=5 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= affil-num=6 en-affil=Department of Pharmacy, Okayama City Hospital kn-affil= affil-num=7 en-affil=Department of Internal Medicine, Yonago Medical Center kn-affil= affil-num=8 en-affil=Department of Pharmacy, Marugame Medical Center kn-affil= affil-num=9 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=10 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Pharmacy, Kasaoka City Hospital kn-affil= affil-num=12 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=13 en-affil=Department of Nursing, Okayama Kyokuto Hospital kn-affil= affil-num=14 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=15 en-affil=Department of Pharymacy, Okayama Memorial Hospital kn-affil= affil-num=16 en-affil=Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=6 article-no= start-page=763 end-page=766 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants. en-copyright= kn-copyright= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SekitoTakanori en-aut-sei=Sekito en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WatariShogo en-aut-sei=Watari en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NagaoKentaro en-aut-sei=Nagao en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TominagaYusuke en-aut-sei=Tominaga en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakamotoAtsushi en-aut-sei=Takamoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SakoTomoko en-aut-sei=Sako en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=IshiiAyano en-aut-sei=Ishii en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=WatanabeMasami en-aut-sei=Watanabe en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=16 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=17 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=18 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=19 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=20 en-affil=Department of Urology, Okayama University Hospital kn-affil= en-keyword=genitourinary tract infections kn-keyword=genitourinary tract infections en-keyword=fluoroquinolone resistance kn-keyword=fluoroquinolone resistance en-keyword=extended-spectrum beta-lactamase kn-keyword=extended-spectrum beta-lactamase END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=6 article-no= start-page=719 end-page=724 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Significance of Age and Causative Bacterial Morphology in the Choice of an Antimicrobial Agent to Treat Acute Uncomplicated Cystitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis. en-copyright= kn-copyright= en-aut-name=UeharaShinya en-aut-sei=Uehara en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujioKei en-aut-sei=Fujio en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamasakiTomoya en-aut-sei=Yamasaki en-aut-mei=Tomoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtsukiHideo en-aut-sei=Otsuki en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=3 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=4 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= en-keyword=acute uncomplicated cystitis kn-keyword=acute uncomplicated cystitis en-keyword=oral antimicrobial agents kn-keyword=oral antimicrobial agents en-keyword=antimicrobial susceptibility kn-keyword=antimicrobial susceptibility en-keyword=menopause kn-keyword=menopause en-keyword=Gram stain kn-keyword=Gram stain END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=663 end-page=667 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. en-copyright= kn-copyright= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiyamaYoshiki en-aut-sei=Hiyama en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitanoHiroyuki en-aut-sei=Kitano en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamadaHiroki en-aut-sei=Yamada en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GotoTakayuki en-aut-sei=Goto en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KondoTsubasa en-aut-sei=Kondo en-aut-mei=Tsubasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShigemuraKatsumi en-aut-sei=Shigemura en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=WatanabeMasami en-aut-sei=Watanabe en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TakenakaTadasu en-aut-sei=Takenaka en-aut-mei=Tadasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TeishimaJun en-aut-sei=Teishima en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MiyataYasuyoshi en-aut-sei=Miyata en-aut-mei=Yasuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=IshikawaKiyohito en-aut-sei=Ishikawa en-aut-mei=Kiyohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TakaokaEi-Ichiro en-aut-sei=Takaoka en-aut-mei=Ei-Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=MiyazakiJun en-aut-sei=Miyazaki en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TakahashiSatoshi en-aut-sei=Takahashi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=MasumoriNaoya en-aut-sei=Masumori en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=KiyotaHiroshi en-aut-sei=Kiyota en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=FujisawaMasato en-aut-sei=Fujisawa en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=YamamotoShingo en-aut-sei=Yamamoto en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=SakumaTakafumi en-aut-sei=Sakuma en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=KusumiNorihiro en-aut-sei=Kusumi en-aut-mei=Norihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=IchikawaTakaharu en-aut-sei=Ichikawa en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= en-aut-name=NasuYoshitsugu en-aut-sei=Nasu en-aut-mei=Yoshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=29 ORCID= en-aut-name=TsugawaMasaya en-aut-sei=Tsugawa en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=30 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=31 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=32 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Hakodate Goryoukaku Hospital kn-affil= affil-num=4 en-affil=Hiroshima University Hospital kn-affil= affil-num=5 en-affil=Jikei University Katsushika Medical Center kn-affil= affil-num=6 en-affil=Kyoto University Hospital kn-affil= affil-num=7 en-affil=Nagasaki University Hospital kn-affil= affil-num=8 en-affil=Kobe University Hospital kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Japanese Red Cross Okayama Hospital kn-affil= affil-num=15 en-affil=Hiroshima University Hospital kn-affil= affil-num=16 en-affil=Nagasaki University Hospital kn-affil= affil-num=17 en-affil=Fujita Health University Hospital kn-affil= affil-num=18 en-affil=Internationla University of Health and Welfare Hospital kn-affil= affil-num=19 en-affil=Internationla University of Health and Welfare Hospital kn-affil= affil-num=20 en-affil=Sapporo Medical University Hospital kn-affil= affil-num=21 en-affil=Sapporo Medical University Hospital kn-affil= affil-num=22 en-affil=Jikei University Katsushika Medical Center kn-affil= affil-num=23 en-affil=Kobe University Hospital kn-affil= affil-num=24 en-affil=Hyogo College of Medicine College Hospital kn-affil= affil-num=25 en-affil=Okayama Medical Center kn-affil= affil-num=26 en-affil=Okayama Medical Center kn-affil= affil-num=27 en-affil=Okayama Medical Center kn-affil= affil-num=28 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=29 en-affil=Okayama Rosai Hospital kn-affil= affil-num=30 en-affil=Okayama City General Medical Center kn-affil= affil-num=31 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=32 en-affil=Department of Urology, Okayama University Hospital kn-affil= en-keyword=antibiotic prophylaxis kn-keyword=antibiotic prophylaxis en-keyword=selective culture media kn-keyword=selective culture media en-keyword=prostate biopsy kn-keyword=prostate biopsy en-keyword=fluoroquinolone-resistant kn-keyword=fluoroquinolone-resistant en-keyword=extended- spectrum beta-lactamase kn-keyword=extended- spectrum beta-lactamase END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=13 article-no= start-page=e25265 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Disseminated gonococcal infection in a Japanese man with complement 7 deficiency with compound heterozygous variants A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rationale: Complement deficiency are known to be predisposed to disseminated gonococcal infection (DGI). We herein present a case of DGI involving a Japanese man who latently had a complement 7 deficiency with compound heterozygous variants.
Patient concerns: A previously healthy 51-year-old Japanese man complained of sudden-onset high fever. Physical examination revealed various skin lesions including red papules on his trunk and extremities, an impetigo-like pustule on left forearm, and tendinitis of his right forefinger.
Diagnosis: Blood culture testing detected gram-negative cocci, which was confirmed to be Neisseria gonorrhoeae based on mass spectrometry and a pathogen-specific PCR test.
Interventions: Screening tests for underlying immunocompromised factors uncovered that complement activities (CH50) was undetectable. With a suspicion of a congenital complement deficiency, genetic analysis revealed rare single nucleotide variants in complement 7 (C7), including c.281-1G>T and a novel variant c.1454C>T (p.A485V). CH50 was normally recovered by adding purified human C7 to the patient's serum, supporting that the patient has C7 deficiency with compound heterozygous variants.
Outcomes: Under a diagnosis of DGI, the patient underwent an antibiotic treatment with cefotaxime for a week and was discharged without any sequela.
Lessons: DGI is a rare sexually-transmitted infection that potentially induces systemic complications. Complement immunity usually defeats N. gonorrhoeae and prevents the organism from causing DGI. This case highlighted the importance of suspecting a complement deficiency when a person develops DGI. en-copyright= kn-copyright= en-aut-name=KageyamaMisaki en-aut-sei=Kageyama en-aut-mei=Misaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UedaYasutaka en-aut-sei=Ueda en-aut-mei=Yasutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaniKatsuki en-aut-sei=Ohtani en-aut-mei=Katsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FukumoriYasuo en-aut-sei=Fukumori en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InoueNorimitsu en-aut-sei=Inoue en-aut-mei=Norimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WakamiyaNobutaka en-aut-sei=Wakamiya en-aut-mei=Nobutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YonedaNanoka en-aut-sei=Yoneda en-aut-mei=Nanoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KimuraKeigo en-aut-sei=Kimura en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NagasawaMotonori en-aut-sei=Nagasawa en-aut-mei=Motonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NakagamiFutoshi en-aut-sei=Nakagami en-aut-mei=Futoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NishiIsao en-aut-sei=Nishi en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SugimotoKen en-aut-sei=Sugimoto en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=RakugiHiromi en-aut-sei=Rakugi en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= affil-num=2 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Osaka University Hospital kn-affil= affil-num=4 en-affil=The Japanese Association for Complement Research kn-affil= affil-num=5 en-affil=Department of Molecular Genetics, Wakayama Medical University kn-affil= affil-num=6 en-affil=The Japanese Association for Complement Research kn-affil= affil-num=7 en-affil=The Japanese Association for Complement Research kn-affil= affil-num=8 en-affil=Laboratory for Clinical Investigation, Osaka University Hospital kn-affil= affil-num=9 en-affil=Laboratory for Clinical Investigation, Osaka University Hospital kn-affil= affil-num=10 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= affil-num=11 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= affil-num=12 en-affil=Laboratory for Clinical Investigation, Osaka University Hospital kn-affil= affil-num=13 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= affil-num=14 en-affil=Department of General Medicine, Osaka University Hospital kn-affil= en-keyword=complement addition test kn-keyword=complement addition test en-keyword=complement deficiency kn-keyword=complement deficiency en-keyword=disseminated gonococcal infection kn-keyword=disseminated gonococcal infection en-keyword=genome analysis kn-keyword=genome analysis en-keyword=Neisseria gonorrhoeae kn-keyword=Neisseria gonorrhoeae en-keyword=sexually transmitted infection kn-keyword=sexually transmitted infection END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3 article-no= start-page=279 end-page=287 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202106 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Gram-negative Rod Blood Stream Infection on Acute GVHD in Allogeneic Hematopoietic Stem Cell Transplantation: A Single-institute Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. en-copyright= kn-copyright= en-aut-name=NishinoharaMasa-aki en-aut-sei=Nishinohara en-aut-mei=Masa-aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujiiKeiko en-aut-sei=Fujii en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=blood stream infection kn-keyword=blood stream infection en-keyword=graft-versus-host disease kn-keyword=graft-versus-host disease en-keyword=gram negative rods kn-keyword=gram negative rods END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue= article-no= start-page=70 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prospective cohort study of febrile neutropenia in breast cancer patients administered with neoadjuvant and adjuvant chemotherapies: CSPOR-BC FN study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
As Asians are more vulnerable to febrile neutropenia (FN) than Caucasians, evaluations of FN incidence and risk factors in Asians are important for the appropriate use of primary pegfilgrastim (PEG-G).
Patients and methods
Japanese breast cancer patients receiving standard adjuvant chemotherapies were prospectively enrolled in multicenter institutions from August 2015 to July 2017. FN was evaluated from 2 treatment policies: true FN (T-FN): ≥37.5 °C, grade 4 neutropenia, mandatory hospital visit (visiting); surrogate FN (S-FN): ≥37.5 °C, oral antibiotic, no mandatory visit (non-visiting). PEG-G was used at the physicians’ discretion. The primary endpoint was FN incidence during all cycles. Multivariate logistic regression analysis was performed to identify T-FN risk factors.
Results
Of 1005 enrolled patients, 980 women treated with FEC, E(A)C, and TC were analyzed. The FN incidence proportions in all patients were 22.5%, 27.5%, and 33.9% for FEC, E(A)C, and TC, respectively. Those of T-FN were 27.7%, 22.4%, and 36.6%; those of S-FN were 17.3%, 32.4%, and 31.5% with more frequent primary PEG-G usage. The relative dose intensity (RDI) of the 3 regimens was ≥0.85 in both groups. In the analysis of risk factors, TC (odds ratio = 2.67), age ≥ 65 years (2.24), and pretreatment absolute neutrophil count (ANC)/1000 μl (0.8) remained significant.
Conclusions
FN incidences were above 20% in the 3 regimens, with TC showing the highest. RDI was maintained at a high level in both visiting and non-visiting groups. Patient-related risk factors were age and pretreatment ANC. en-copyright= kn-copyright= en-aut-name=IshikawaTakashi en-aut-sei=Ishikawa en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamakiKentaro en-aut-sei=Sakamaki en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaruiKazutaka en-aut-sei=Narui en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishimuraHideki en-aut-sei=Nishimura en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SangaiTakafumi en-aut-sei=Sangai en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TamakiKentaro en-aut-sei=Tamaki en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HasegawaYoshie en-aut-sei=Hasegawa en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WatanabeKen-ichi en-aut-sei=Watanabe en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SuganumaNobuyasu en-aut-sei=Suganuma en-aut-mei=Nobuyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MichishitaShintaro en-aut-sei=Michishita en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SugaeSadatoshi en-aut-sei=Sugae en-aut-mei=Sadatoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AiharaTomohiko en-aut-sei=Aihara en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TsugawaKoichiro en-aut-sei=Tsugawa en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KaiseHirose en-aut-sei=Kaise en-aut-mei=Hirose kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MukaiHirofumi en-aut-sei=Mukai en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Breast Surgery and Oncology, Tokyo Medical University kn-affil= affil-num=2 en-affil=Department of Biostatistics, Yokohama City University kn-affil= affil-num=3 en-affil=Department of Biostatistics, Yokohama City University kn-affil= affil-num=4 en-affil=Department of Biostatistics, Yokohama City University kn-affil= affil-num=5 en-affil=Department of Breast and Thyroid Surgery, Chiba University kn-affil= affil-num=6 en-affil=Naha-Nishi Clinic kn-affil= affil-num=7 en-affil=Department of Breast Surgery, Hirosaki Municipal Hospita kn-affil= affil-num=8 en-affil=Department of Breast Surgery, Hokkaido Cancer Center kn-affil= affil-num=9 en-affil=Department of Breast and Thyroid Surgery, Kanagawa Cancer Center kn-affil= affil-num=10 en-affil=Department of Breast Surgery, Yao Municipal Hospital kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine kn-affil= affil-num=12 en-affil=Breast Center, Aihara Hospital kn-affil= affil-num=13 en-affil=Department of Breast and Thyroid Surgery, St. Marianna University kn-affil= affil-num=14 en-affil=Department of Breast Surgery and Oncology, Tokyo Medical University kn-affil= affil-num=15 en-affil=Department of Breast and Endocrinology Surgery, Okayama University Graduate School of Medicine kn-affil= affil-num=16 en-affil=Division of Oncology/Hematology, National Cancer Center Hospital East kn-affil= en-keyword=Breast cancer kn-keyword=Breast cancer en-keyword=Febrile neutropenia kn-keyword=Febrile neutropenia en-keyword=Adjuvant chemotherapy kn-keyword=Adjuvant chemotherapy en-keyword=Risk factors kn-keyword=Risk factors en-keyword=Prospective study kn-keyword=Prospective study END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=10 article-no= start-page=1026 end-page=1032 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Concomitant vancomycin and piperacillin/tazobactam treatment is associated with an increased risk of acute kidney injury in Japanese patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction
Recent studies have corroborated that the co-administration of vancomycin (VCM) and piperacillin/tazobactam (PT) is correlated with an increased incidence of acute kidney injury (AKI). However, evidence directed at the Japanese population is scarce. Therefore, we conducted a retrospective study to compare the occurrence of AKI among Japanese patients who received VCM with PT (VP therapy) and VCM with another β-lactams (VA therapy).
Methods
The present study, performed at Tsuyama Chuo Hospital between June 2012 and December 2018, included adult patients who received VCM and β-lactam antibiotics for ≥48 h. We defined the primary outcome as the incidence of AKI based on the risk, injury, failure, loss, and end-stage kidney disease criteria. Patients' clinical characteristics and outcomes were reviewed and compared between the two groups with univariate and multivariate logistic regression analyses. Subgroup analysis was conducted by stratifying the patients’ baseline hospital admittance status, as intensive care unit or general wards.
Results
We analyzed 272 patients (92 V P therapy and 180 VA therapy). Univariate analysis revealed a significant difference in AKI development between VP and VA therapy (25.0% vs 12.2%; p < 0.01). A multivariate analysis demonstrated that VP therapy and VCM initial trough levels ≥15 μg/mL were associated with an incidence of AKI. Patients at general wards, rather than those admitted at an intensive care unit, developed AKI with VP therapy (p = 0.02).
Conclusion
VP therapy was associated with an increased risk of AKI compared to that with VA therapy among the Japanese population. en-copyright= kn-copyright= en-aut-name=HarukiYuto en-aut-sei=Haruki en-aut-mei=Yuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HarukiMai en-aut-sei=Haruki en-aut-mei=Mai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InoueYuta en-aut-sei=Inoue en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugiyamaTetsuhiro en-aut-sei=Sugiyama en-aut-mei=Tetsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= affil-num=4 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= affil-num=5 en-affil=Department of Pharmacy, Tsuyama Chuo Hospital kn-affil= en-keyword=Acute kidney injury kn-keyword=Acute kidney injury en-keyword=β-lactams kn-keyword=β-lactams en-keyword=Piperacillin/tazobactam kn-keyword=Piperacillin/tazobactam en-keyword=Vancomycin kn-keyword=Vancomycin END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=22 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 70-year-old Japanese man undergoing remission induction therapy for acute monocytic leukemia (AML-M5b) developed fever and headache, and was started on antibiotics and liposomal amphotericin B (L-AMB). There was no improvement, and computed tomography and contrast-enhanced magnetic resonance imaging revealed acute rhinosinusitis and brain abscess. Successful endoscopic endonasal surgery was performed at this point, providing drainage for the rhinosinusitis and abscess. Histopathological findings showed the mucormycosis. en-copyright= kn-copyright= en-aut-name=UraguchiKensuke en-aut-sei=Uraguchi en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KozakuraKenichi en-aut-sei=Kozakura en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkaSatoshi en-aut-sei=Oka en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HigakiTakaya en-aut-sei=Higaki en-aut-mei=Takaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MakiharaSeiichiro en-aut-sei=Makihara en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ImaiToshi en-aut-sei=Imai en-aut-mei=Toshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DoiAkira en-aut-sei=Doi en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaTsuyoshi en-aut-sei=Ohta en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KariyaShin en-aut-sei=Kariya en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Otorhinolaryngology, Kochi Health Sciences Center kn-affil= affil-num=3 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=4 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Kagawa Rosai Hospital kn-affil= affil-num=6 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=7 en-affil=Department of Otorhinolaryngology, Kochi Health Sciences Center kn-affil= affil-num=8 en-affil=Department of Neurosurgery, Kochi Health Sciences Center kn-affil= affil-num=9 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Rhinocerebral mucormycosis kn-keyword=Rhinocerebral mucormycosis en-keyword=Acute rhinosinusitis kn-keyword=Acute rhinosinusitis en-keyword=Brain abscess kn-keyword=Brain abscess en-keyword=Endoscopic endonasal skull base surgery kn-keyword=Endoscopic endonasal skull base surgery en-keyword=Acute monocytic leukemia kn-keyword=Acute monocytic leukemia END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=10 article-no= start-page=1107 end-page=1109 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antibiotic literacy among Japanese medical students en-subtitle= kn-subtitle= en-abstract= kn-abstract=Antimicrobial resistance (AMR) is an urgent global issue. After the AMR action plan was introduced in 2016, a study on antibiotic literacy (i.e., awareness, knowledge, and attitude relating to antimicrobial use) among clinicians and lay people was conducted in Japan. However, no studies have hitherto targeted medical students who are expected to have a high level of antibiotic literacy. The present study was conducted between September 2019 and February 2020, enrolling undergraduate students at Okayama University Medical School. We collected data using a paper-based questionnaire form with 11 questions about antibiotic literacy. The response rate was 93.8% (661/705 students). Overall, 92.6% of the students knew that antibiotics inhibit the growth of bacteria. Student reporting that antibiotics could treat the common cold accounted for 77.0% (Year 1), 50.9% (Year 2), 48.2% (Year 3), 49.1% (Year 4), 23.8% (Year 5), and 26.2% (Year 6). Only 43 (6.5%) had heard about the AMR action plan. The study data suggested that medical students' level of literacy on antimicrobial use should be further enhanced to address AMR and promote antimicrobial stewardship. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoHideo en-aut-sei=Ino en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaHiroko en-aut-sei=Ogawa en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OchiKanako en-aut-sei=Ochi en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Center for Education in Medicine and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Center for Education in Medicine and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Antimicrobial resistance kn-keyword=Antimicrobial resistance en-keyword=Antibiotic literacy kn-keyword=Antibiotic literacy en-keyword=Antibiotics kn-keyword=Antibiotics en-keyword=Students kn-keyword=Students en-keyword=Medical education kn-keyword=Medical education END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=365 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. en-copyright= kn-copyright= en-aut-name=ChumaMasayuki en-aut-sei=Chuma en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KondoMasateru en-aut-sei=Kondo en-aut-mei=Masateru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakechiKenshi en-aut-sei=Takechi en-aut-mei=Kenshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkadaNaoto en-aut-sei=Okada en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShibataAkitomo en-aut-sei=Shibata en-aut-mei=Akitomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AsadaMizuho en-aut-sei=Asada en-aut-mei=Mizuho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtoJun en-aut-sei=Oto en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YanagawaHiroaki en-aut-sei=Yanagawa en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IshizawaKeisuke en-aut-sei=Ishizawa en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital kn-affil= affil-num=2 en-affil=Department of Pharmacy, Tokushima University Hospital kn-affil= affil-num=3 en-affil=Department of Pharmacy, Tokushima University Hospital kn-affil= affil-num=4 en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital kn-affil= affil-num=5 en-affil=Department of Pharmacy, Tokushima University Hospital kn-affil= affil-num=6 en-affil=Department of Pharmacy, Tokushima University Hospital kn-affil= affil-num=7 en-affil=Department of Pharmacy, Saiseikai Kumamoto Hospital kn-affil= affil-num=8 en-affil=Department of Pharmacy, Medical Hospital, Tokyo Medical and Dental University kn-affil= affil-num=9 en-affil=Department of Emergency and Critical Care Medicine, Tokushima University Graduate School of Biomedical Sciences kn-affil= affil-num=10 en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital kn-affil= affil-num=11 en-affil=Department of Pharmacy, Tokushima University Hospital kn-affil= en-keyword=vancomycin, kn-keyword=vancomycin, en-keyword=therapeutic drug monitoring kn-keyword=therapeutic drug monitoring en-keyword=cystatin C kn-keyword=cystatin C en-keyword=bacterial meningitis kn-keyword=bacterial meningitis en-keyword=sepsis kn-keyword=sepsis END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=1 article-no= start-page=175 end-page=178 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Peritonsillar abscess with otorrhea kn-title=耳漏を主訴に来院した扁桃周囲膿瘍の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The patient was a 79-year-old woman. Her left ear was being treated with otitis externa at her nearby clinic by eardrop. Her otorrhea did not improve after one week. The otorrhea still kept outflowing during food intake. That is the reason of her visiting our hospital. Her past medical histories were sigmoid colon perforation with stoma placement, rheumatoid arthritis, diabetes mellitus, hypertension, right hip prosthesis placement. At the first visit to our hospita!, She had a remarkable erosion of the left ear canal, fistula was found in front of the ear canal skin. She showed pus leakage due to her chewing. Strongly swelling surrounded the left tonsil and soft palate, and oropharynx had been narrowed. T he CT scan revealed the low density area with a contrast effect from the lower ear to the left tonsil, was diagnosed with left peritonsillar abscess. On admission to our hospital, drainage and the administration of antibiotics were performed. She was discharged in satisfactory progress on day 10. Peritonsillar abscess, but there is a frequently encountered disease, being the chief complaint otorrhea is rare. As reported case seems to be similar as far as we have searched is only reported as "one case of deep neck abscess in the throat and ear canal causing self-destruction" is Tomohiro Anno 1961. We report this case with the literature about peritonsillar abscess. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大道亮太郎 kn-aut-sei=大道 kn-aut-mei=亮太郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西﨑和則 kn-aut-sei=西﨑 kn-aut-mei=和則 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=香川労災病院耳鼻咽喉科・頭頸部外科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学 END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=521 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
The widespread administration of the Haemophilus influenzae type b vaccine has led to the predominance of non-typable H. influenzae (NTHi). However, the occurrence of invasive NTHi infection based on gynecologic diseases is still rare.
Case presentation
A 51-year-old Japanese woman with a history of adenomyoma presented with fever. Blood cultures and a vaginal discharge culture were positive with NTHi. With the high uptake in the uterus with 67Ga scintigraphy, she was diagnosed with invasive NTHi infection. In addition to antibiotic administrations, a total hysterectomy was performed. The pathological analysis found microabscess formations in adenomyosis.
Conclusions
Although NTHi bacteremia consequent to a microabscess in adenomyosis is rare, this case emphasizes the need to consider the uterus as a potential source of infection in patients with underlying gynecological diseases, including an invasive NTHi infection with no known primary focus.. en-copyright= kn-copyright= en-aut-name=NishimuraYoshito en-aut-sei=Nishimura en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawanoKaoru en-aut-sei=Kawano en-aut-mei=Kaoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokotaYuya en-aut-sei=Yokota en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkaKosuke en-aut-sei=Oka en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HasegawaKou en-aut-sei=Hasegawa en-aut-mei=Kou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HarumaTomoko en-aut-sei=Haruma en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OnoSawako en-aut-sei=Ono en-aut-mei=Sawako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MasuyamaHisashi en-aut-sei=Masuyama en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Microbiology Division, Clinical Laboratory,Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pathology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Non-typable Haemophilus influenzae kn-keyword=Non-typable Haemophilus influenzae en-keyword=Bacteremia kn-keyword=Bacteremia en-keyword=beta-Lactamase-nonproducing ampicillin-resistance kn-keyword=beta-Lactamase-nonproducing ampicillin-resistance en-keyword=Adenomyosis kn-keyword=Adenomyosis en-keyword=Case report kn-keyword=Case report END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=261 end-page=264 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Randomized Phase 2 Trial of Antibiotic Prophylaxis Versus No Intervention for Muscle Biopsy in A Neurology Department en-subtitle= kn-subtitle= en-abstract= kn-abstract=Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population. en-copyright= kn-copyright= en-aut-name=NakaharaKeiichi en-aut-sei=Nakahara en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaTokunori en-aut-sei=Ikeda en-aut-mei=Tokunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakamatsuKoutaro en-aut-sei=Takamatsu en-aut-mei=Koutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TawaraNozomu en-aut-sei=Tawara en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaraKentaro en-aut-sei=Hara en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EnokidaYuki en-aut-sei=Enokida en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanoueNaomi en-aut-sei=Tanoue en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NaritaSawana en-aut-sei=Narita en-aut-mei=Sawana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiiAkiko en-aut-sei=Fujii en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamanouchiYoshinori en-aut-sei=Yamanouchi en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MorinagaJun en-aut-sei=Morinaga en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamashitaSatoshi en-aut-sei=Yamashita en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=2 en-affil= Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=6 en-affil=Department of Pharmacy, Kumamoto University Hospital kn-affil= affil-num=7 en-affil=Department of Pharmacy, Kumamoto University Hospital kn-affil= affil-num=8 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=9 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=10 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=11 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= en-keyword=muscle biopsy kn-keyword=muscle biopsy en-keyword=antibiotic prophylaxis kn-keyword=antibiotic prophylaxis END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=251 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Treatment of Staphylococcus schleiferi Infection after Aortic Arch Repair: In Situ Aortic Arch Replacement and Domino Reconstruction of the Debranching Graft using Autologous Iliac Artery en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 62-year-old Japanese male presented with graft infection by Staphylococcus schleiferi 50 days after debranching of the left subclavian artery and frozen elephant trunk repair for the entry closure of a Stanford type B aortic dissection. The graft was removed, and the patient was successfully treated using in situ reconstruction of the arch with omental flap coverage, removal of the debranching graft, autologous iliac artery grafting, and longterm antibiotics. Domino reconstruction of the infected debranching graft using autologous external iliac artery and a Dacron graft can thus be a good option in similar cases. en-copyright= kn-copyright= en-aut-name=MurakamiTakashi en-aut-sei=Murakami en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TokudaTakanori en-aut-sei=Tokuda en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishimuraShinsuke en-aut-sei=Nishimura en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujiiHiromichi en-aut-sei=Fujii en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiYosuke en-aut-sei=Takahashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaneKokoro en-aut-sei=Yamane en-aut-mei=Kokoro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=InoueKazushige en-aut-sei=Inoue en-aut-mei=Kazushige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamadaKoichi en-aut-sei=Yamada en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KakeyaHiroshi en-aut-sei=Kakeya en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShibataToshihiko en-aut-sei=Shibata en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Cardiovascular Surgery, Hirakata Kosai Hospital kn-affil= affil-num=3 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Department of Cardiovascular Surgery, Hirakata Kosai Hospital kn-affil= affil-num=8 en-affil=Department of Infection Control Science, Osaka City University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of Infection Control Science, Osaka City University Graduate School of Medicine kn-affil= affil-num=10 en-affil=Department of aCardiovascular Surgery,Osaka City University Graduate School of Medicine kn-affil= en-keyword=autologous iliac artery graft kn-keyword=autologous iliac artery graft en-keyword=Staphylococcus schleiferi kn-keyword=Staphylococcus schleiferi en-keyword=graft infection kn-keyword=graft infection en-keyword=domino reconstruction kn-keyword=domino reconstruction en-keyword=Dacron graft kn-keyword=Dacron graft END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=8 article-no= start-page=843 end-page=846 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mycobacterium chelonae bloodstream infection induced by osteomyelitis of toe: A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mycobacterium chelonae is a rapidly growing mycobacterium that has the potential to cause refractory infections in humans. Mycobacteremia resulting from the organism is extremely rare, and its clinical features are yet to be uncovered. We herein present a case of M. chelonae bloodstream infection involving an immunocompromised older patient. A 79-year-old woman, on a long-term treatment with prednisolone plus tacrolimus for rheumatoid arthritis, visited our outpatient department complaining of deteriorating pain and swelling at her right 1st toe. Laboratory parameters showed elevated C-reactive protein and leukocytosis, and magnetic resonance imaging indicated osteomyelitis at the proximal phalanx of her right 1st toe. Considering the refractory course, the infected toe was immediately amputated. M. chelonae was isolated from bacterial cultures of the resected tissue and blood (BD BACTEC™ FX blood culture system, Becton Dickinson, Sparks, MD, USA), leading to a diagnosis of disseminated M. chelonae infection. We treated the patient with an antibiotic combination of clarithromycin, minocycline, and imipenem (2 weeks), which was converted to oral therapy of clarithromycin, doxycycline, and levofloxacin. This case highlighted the potential pathogenesis of M. chelonae to cause mycobacteremia in an immunocompromised patient. en-copyright= kn-copyright= en-aut-name=UedaYayoi en-aut-sei=Ueda en-aut-mei=Yayoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujimoriTakumi en-aut-sei=Fujimori en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KakehiAyaka en-aut-sei=Kakehi en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkuraMami en-aut-sei=Okura en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MinabeHiroshi en-aut-sei=Minabe en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=5 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=6 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=7 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=8 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=9 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Mycobacterium chelonae kn-keyword=Mycobacterium chelonae en-keyword=Mycobacteremia kn-keyword=Mycobacteremia en-keyword=Non-tuberculous mycobacteria kn-keyword=Non-tuberculous mycobacteria en-keyword=Osteomyelitis kn-keyword=Osteomyelitis en-keyword=Rapidly growing mycobacteria kn-keyword=Rapidly growing mycobacteria en-keyword=Rheumatoid arthritis kn-keyword=Rheumatoid arthritis END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=449 end-page=456 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acute Prevertebral Abscesses Caused by Bacterial-infected Traumatic Tooth Fractures en-subtitle= kn-subtitle= en-abstract= kn-abstract= We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fractures induced the acute prevertebral abscesses. en-copyright= kn-copyright= en-aut-name=MatsunagaKazuyuki en-aut-sei=Matsunaga en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakemaruMakoto en-aut-sei=Takemaru en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Yamashiro Keisuke en-aut-sei=Yamashiro en-aut-mei= Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Yoshihara-HirataChiaki en-aut-sei=Yoshihara-Hirata en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InoharaKen en-aut-sei=Inohara en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShimoeYutaka en-aut-sei=Shimoe en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaAkio en-aut-sei=Tanaka en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KuriyamaMasaru en-aut-sei=Kuriyama en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=Takashiba Shogo en-aut-sei=Takashiba en-aut-mei= Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=2 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=3 en-affil=Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=6 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=7 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=8 en-affil=Department of Neurology, Brain Attack Center Ota Memorial Hospital kn-affil= affil-num=9 en-affil=Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=prevertebral abscess kn-keyword=prevertebral abscess en-keyword=deep neck infection kn-keyword=deep neck infection en-keyword=periodontal disease kn-keyword=periodontal disease en-keyword=peri-implantitis kn-keyword=peri-implantitis en-keyword=Streptococcus parasanguinis kn-keyword=Streptococcus parasanguinis END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=6 article-no= start-page=601 end-page=604 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Salmonella Osteomyelitis of the Distal Tibia in a Healthy Woman en-subtitle= kn-subtitle= en-abstract= kn-abstract= Salmonella osteomyelitis is extremely rare; only a few cases have been reported in healthy adults. We describe a case of salmonella osteomyelitis in an otherwise healthy 20-year-old Japanese woman who presented with distal tibial pain. X-ray and magnetic resonance imaging showed a lesion suspected to be a bone cyst. Osteomyelitis was diagnosed when pus was observed during an open biopsy. The bacterial culture examination yielded salmonella. Surgical drainage and antibiotic treatment were performed, after which no recurrence was observed. To our best knowledge, this is the first report of salmonella osteomyelitis of the distal tibia in an otherwise healthy individual. en-copyright= kn-copyright= en-aut-name=HashimotoKazuhiko en-aut-sei=Hashimoto en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraShunji en-aut-sei=Nishimura en-aut-mei=Shunji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Iemura Shunki en-aut-sei=Iemura en-aut-mei= Shunki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkagiMasao en-aut-sei=Akagi en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=2 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=3 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=4 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= en-keyword=osteomyelitis kn-keyword=osteomyelitis en-keyword=salmonella kn-keyword=salmonella en-keyword= tibia kn-keyword= tibia en-keyword=healthy woman kn-keyword=healthy woman END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=189 end-page=192 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Helicobacter cinaedi-associated Carotid Arteritis en-subtitle= kn-subtitle= en-abstract= kn-abstract= A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks. Although the relationship between H. cinaedi infection and atherosclerosis development remains unclear, the atherosclerotic changes in our patient’s carotid artery might have been attributable to H. cinaedi infection. en-copyright= kn-copyright= en-aut-name=NakaoShinichiro en-aut-sei=Nakao en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimuraKeigo en-aut-sei=Kimura en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuiTomomi en-aut-sei=Mitsui en-aut-mei=Tomomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OyamaAkane en-aut-sei=Oyama en-aut-mei=Akane kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HongyoKazuhiro en-aut-sei=Hongyo en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiYusuke en-aut-sei=Takahashi en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakagamiFutoshi en-aut-sei=Nakagami en-aut-mei=Futoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TomonoKazunori en-aut-sei=Tomono en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=RakugiHiromi en-aut-sei=Rakugi en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= affil-num=2 en-affil=Division of Infection Control and Prevention, Osaka University Hospital kn-affil= affil-num=3 en-affil=Laboratory for Clinical Investigation, Osaka University Hospital kn-affil= affil-num=4 en-affil=Laboratory for Clinical Investigation, Osaka University Hospital kn-affil= affil-num=5 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= affil-num=6 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= affil-num=7 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= affil-num=8 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= affil-num=9 en-affil=Division of Infection Control and Prevention, Osaka University Hospital kn-affil= affil-num=10 en-affil=Department of General Internal Medicine, Osaka University Hospital kn-affil= en-keyword=atherosclerosis kn-keyword=atherosclerosis en-keyword=bacteremia kn-keyword=bacteremia en-keyword=bacterial translocation kn-keyword=bacterial translocation en-keyword=Helicobacter cinaedi kn-keyword=Helicobacter cinaedi en-keyword=vascular infection kn-keyword=vascular infection END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6 article-no= start-page=547 end-page=552 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Disseminated Nontuberculous Mycobacterial Infection in a Patient with Anti-IFN-γ Autoantibodies en-subtitle= kn-subtitle= en-abstract= kn-abstract= We treated a 72-year-old Japanese female with sustained high fever and overall body exhaustion. An infectious liver cyst and right lung pneumonia were suspected causes. Hepatic cystectomy and various antibiotics did not resolve symptoms. Pneumonia exacerbation and ascitic fluid retention, left lumbar spinal osteomyelitis, and peri-gastric lymph node abscess penetrating the stomach were observed. Mycobacterium avium was identified in sputum, ascites, vertebral body abscess puncture specimen, and pus mucus secretion in the stomach. We diagnosed a disseminated nontuberculous mycobacterial infection. She seemed immunocompetent, without signs of AIDS or hematological malignancy. Serum anti-IFN-γ autoantibodies tested positive and were suspected to be involved in the illness onset. en-copyright= kn-copyright= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HashimotoMasayuki en-aut-sei=Hashimoto en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Internal Medicine, Tottori Municipal Hospital kn-affil= affil-num=2 en-affil=Department of Surgery, Tottori Municipal Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Tottori Municipal Hospital kn-affil= en-keyword=disseminated nontuberculous mycobacterial infection kn-keyword=disseminated nontuberculous mycobacterial infection en-keyword=anti-IFN-γ autoantibodies kn-keyword=anti-IFN-γ autoantibodies END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=107 end-page=109 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Retroperitoneal abscess that ruptured the aorta： Invasive Klebsiella pneumoniae syndrome kn-title=Klebsiella pneumoniae を起因菌とした後腹膜膿瘍からの 炎症波及により腹部大動脈破裂に至った一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= An 80-year-old Japanese man was admitted to our hospital in April 2016 with an acute high-grade fever and back pain. A systemic contrast-enhanced computed tomography scan disclosed a retroperitoneal abscess around his aorta. The blood culture revealed Klebsiella pneumoniae. Antibiotics (Cefotaxime 1 g i.v. q 6 hours) were administered, but the patient's symptoms worsened. The abscess then ruptured the aorta. An emergency surgical repair was done, and the patient recovered. Invasive Klebsiella pneumoniae syndrome has been detected in southeast Asia over the past two decades, and here we describe a rare case of a retroperitoneal abscess caused by Klebsiella pneumoniae that ruptured the aorta. en-copyright= kn-copyright= en-aut-name=YamazakiaKenji en-aut-sei=Yamazakia en-aut-mei=Kenji kn-aut-name=山崎賢士 kn-aut-sei=山崎 kn-aut-mei=賢士 aut-affil-num=1 ORCID= en-aut-name=SakakimaMasanori en-aut-sei=Sakakima en-aut-mei=Masanori kn-aut-name=榊間昌哲 kn-aut-sei=榊間 kn-aut-mei=昌哲 aut-affil-num=2 ORCID= en-aut-name=NagakuraYuka en-aut-sei=Nagakura en-aut-mei=Yuka kn-aut-name=長倉優花 kn-aut-sei=長倉 kn-aut-mei=優花 aut-affil-num=3 ORCID= en-aut-name=HashimotoHiroyuki en-aut-sei=Hashimoto en-aut-mei=Hiroyuki kn-aut-name=橋本紘幸 kn-aut-sei=橋本 kn-aut-mei=紘幸 aut-affil-num=4 ORCID= en-aut-name=TashiroTakeshi en-aut-sei=Tashiro en-aut-mei=Takeshi kn-aut-name=田代傑 kn-aut-sei=田代 kn-aut-mei=傑 aut-affil-num=5 ORCID= en-aut-name=MiwaMasashi en-aut-sei=Miwa en-aut-mei=Masashi kn-aut-name=三輪真史 kn-aut-sei=三輪 kn-aut-mei=真史 aut-affil-num=6 ORCID= en-aut-name=YonemuraKatsuhiko en-aut-sei=Yonemura en-aut-mei=Katsuhiko kn-aut-name=米村克彦 kn-aut-sei=米村 kn-aut-mei=克彦 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　疫学衛生学 affil-num=2 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 affil-num=3 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 affil-num=4 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 affil-num=5 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 affil-num=6 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 affil-num=7 en-affil=Department of Internal Medicine, Fujinomiya City General Hospital kn-affil=富士宮市立病院　内科 en-keyword=invasive Klebsiella pneumoniae syndrome kn-keyword=invasive Klebsiella pneumoniae syndrome en-keyword=腹部大動脈破裂 (ruptured abdominal aorta) kn-keyword=腹部大動脈破裂 (ruptured abdominal aorta) en-keyword=後腹膜膿瘍 (retroperitoneal abscess) kn-keyword=後腹膜膿瘍 (retroperitoneal abscess) END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A refractory cutaneous-rectovesical fistula complicated with abdominal actinomycosis successfully treated with antibiotic therapy kn-title=抗菌化学療法で保存的に閉鎖した放線菌症による 難治性皮膚直腸膀胱瘻の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The patient was a 35-year-old Japanese man diagnosed with appendicitis with abscess formation. An appendectomy was performed, but a refractory surgical wound infection developed, and eventually a cutaneous-rectovesical fistula was detected. In a review of the first-time CT scan, a small high-density construction resembling a bone from a fish was detected in the ileum. The histopathological examination revealed granules of actinomyces. These findings suggested that abdominal actinomycosis due to intestinal mucosal breakage by the fish bone caused the secondary appendicitis, and that after the appendectomy, residual actinomyces caused the cutaneous-rectovesical fistula. After the diagnosis, total parenteral nutrition and a long-term administration of antibiotics improved the patient's clinical symptoms, and the fistula closed within a month. Antibiotics were administered for 6 months, and there has been no recurrence for 6-1/2 years. Because actinomycosis is difficult to diagnose based on the typical clinical features, a direct identification of the infecting organism from a tissue sample or from sulfur granules is required for the definitive diagnosis. Actinomyces is also known to cause fistula formation, and intestinal penetration caused by a fish bone may indicate abdominal actinomycosis. A rectovesical fistula requires surgical intervention in most cases, but in cases caused by abdominal actinomycosis, such a fistula may be cured by conservative therapy, as in our patient's case. It is important to consider the possibility of actinomycosis when a refractory rectovesical fistula is observed. en-copyright= kn-copyright= en-aut-name=KatsuraYuki en-aut-sei=Katsura en-aut-mei=Yuki kn-aut-name=桂佑貴 kn-aut-sei=桂 kn-aut-mei=佑貴 aut-affil-num=1 ORCID= en-aut-name=MatsukawaHiroyoshi en-aut-sei=Matsukawa en-aut-mei=Hiroyoshi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=2 ORCID= en-aut-name=KatoTakuya en-aut-sei=Kato en-aut-mei=Takuya kn-aut-name=加藤卓也 kn-aut-sei=加藤 kn-aut-mei=卓也 aut-affil-num=3 ORCID= en-aut-name=SugiharaMasahiro en-aut-sei=Sugihara en-aut-mei=Masahiro kn-aut-name=杉原正大 kn-aut-sei=杉原 kn-aut-mei=正大 aut-affil-num=4 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=5 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital kn-affil=広島市立広島市民病院　外科 en-keyword=放線菌症 (actinomycosis) kn-keyword=放線菌症 (actinomycosis) en-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) kn-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) en-keyword=急性虫垂炎 (appendicitis) kn-keyword=急性虫垂炎 (appendicitis) END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=123 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Complication of Chronic Eosinophilic Pneumonia in an Elderly Patient with Sjögren Syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients. en-copyright= kn-copyright= en-aut-name=WasedaKoichi en-aut-sei=Waseda en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TerasakaTomohiro en-aut-sei=Terasaka en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KimuraKosuke en-aut-sei=Kimura en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsuzukiTakao en-aut-sei=Tsuzuki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HasegawaKou en-aut-sei=Hasegawa en-aut-mei=Kou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NadaTakahiro en-aut-sei=Nada en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakamuraEri en-aut-sei=Nakamura en-aut-mei=Eri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MurakamiKazutoshi en-aut-sei=Murakami en-aut-mei=Kazutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KondoEisei en-aut-sei=Kondo en-aut-mei=Eisei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=bronchial alveolar lavage kn-keyword=bronchial alveolar lavage en-keyword=eosinophilic pneumonia kn-keyword=eosinophilic pneumonia en-keyword=eosinophilia kn-keyword=eosinophilia en-keyword=interstitial lung diseases kn-keyword=interstitial lung diseases en-keyword=Sjögren syndrome kn-keyword=Sjögren syndrome END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=151 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guideline for the treatment of acute exacerbations of COPD and chronic bronchitis kn-title=慢性呼吸器疾患（COPD，気管支拡張症，陳旧性肺結核等）の気道感染症治療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name=谷本安 kn-aut-sei=谷本 kn-aut-mei=安 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構南岡山医療センター　呼吸器・アレルギー内科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=経皮的気管切開後の創感染に及ぼす抗菌薬投与の効果に関する検討 kn-title=Effects of Antibiotics Administration on the Incidence of Wound Infection in Percutaneous Dilatational Tracheostomy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=251 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for the management of antibiotics by therapeutic drug monitoring kn-title=抗菌薬TDMガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkazakiMasatoshi en-aut-sei=Okazaki en-aut-mei=Masatoshi kn-aut-name=岡崎昌利 kn-aut-sei=岡崎 kn-aut-mei=昌利 aut-affil-num=1 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=67 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guideline for the prevention of postoperative infections kn-title=術後感染予防のための抗菌薬使用ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShinouraSusumu en-aut-sei=Shinoura en-aut-mei=Susumu kn-aut-name=篠浦先 kn-aut-sei=篠浦 kn-aut-mei=先 aut-affil-num=1 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　臓器移植医療センター affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. 　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=塩田澄子 kn-aut-sei=塩田 kn-aut-mei=澄子 aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=三好伸一 kn-aut-sei=三好 kn-aut-mei=伸一 aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=野島宏悦 kn-aut-sei=野島 kn-aut-mei=宏悦 aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=大谷晋吉 kn-aut-sei=大谷 kn-aut-mei=晋吉 aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=杉山淳一 kn-aut-sei=杉山 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=内藤宏道 kn-aut-sei=内藤 kn-aut-mei=宏道 aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=川西進 kn-aut-sei=川西 kn-aut-mei=進 aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=萩岡信吾 kn-aut-sei=萩岡 kn-aut-mei=信吾 aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=森本直樹 kn-aut-sei=森本 kn-aut-mei=直樹 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=2 en-affil= kn-affil=就実大学薬学部　病原微生物学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学 affil-num=4 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=5 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=6 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=7 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=8 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=9 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=10 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=11 en-affil= kn-affil=津山中央病院　救命救急センター en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=221 end-page=225 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acute respiratory distress syndrome following infection of influenza A (H1N1) virus kn-title=新型インフルエンザウイルス（A/H1N1）感染後にARDSを来たした1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 28-year-old man with a history of mental retardation was admitted to our hospital because of dyspnea, cough and high fever. His SpO(2) level at room-environmental conditions was in the eighties, and his chest radiograph showed diffuse infiltrates in both lungs. He was diagnosed as suffering from influenza A by a rapid influenza virus antigen test. The echocardiogram showed no evidence of left cardiac failure; therefore, his symptoms were consistent with acute respiratory distress syndrome (ARDS). Oseltamivir was started, and antibiotics were also given because of the possibility of secondary bacterial infection. Due to respiratory failure and low blood pressure, which suggested septic shock, intensive treatments including mechanical ventilation were performed. Corticosteroid therapy was started for ARDS and sepsis, and these therapies improved his respiratory condition. Polymerase chain reaction of his pharyngeal swab revealed that he had influenza A (H1N1). This is the first case of ARDS following infection by influenza A (H1N1) virus in Japan. en-copyright= kn-copyright= en-aut-name=TaniguchiAkihiko en-aut-sei=Taniguchi en-aut-mei=Akihiko kn-aut-name=谷口暁 kn-aut-sei=谷口 kn-aut-mei=暁 aut-affil-num=1 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name=宮原信明 kn-aut-sei=宮原 kn-aut-mei=信明 aut-affil-num=2 ORCID= en-aut-name=NakaharaAtsushi en-aut-sei=Nakahara en-aut-mei=Atsushi kn-aut-name=中原淳 kn-aut-sei=中原 kn-aut-mei=淳 aut-affil-num=3 ORCID= en-aut-name=TakataSaburo en-aut-sei=Takata en-aut-mei=Saburo kn-aut-name=高田三郎 kn-aut-sei=高田 kn-aut-mei=三郎 aut-affil-num=4 ORCID= en-aut-name=SakugawaRyo en-aut-sei=Sakugawa en-aut-mei=Ryo kn-aut-name=佐久川亮 kn-aut-sei=佐久川 kn-aut-mei=亮 aut-affil-num=5 ORCID= en-aut-name=NaganoOsamu en-aut-sei=Nagano en-aut-mei=Osamu kn-aut-name=長野修 kn-aut-sei=長野 kn-aut-mei=修 aut-affil-num=6 ORCID= en-aut-name=TanimotoYasushi en-aut-sei=Tanimoto en-aut-mei=Yasushi kn-aut-name=谷本安 kn-aut-sei=谷本 kn-aut-mei=安 aut-affil-num=7 ORCID= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=8 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=9 ORCID= en-aut-name=UjikeYoshito en-aut-sei=Ujike en-aut-mei=Yoshito kn-aut-name=氏家良人 kn-aut-sei=氏家 kn-aut-mei=良人 aut-affil-num=10 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=2 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=3 en-affil= kn-affil=岡山大学病院　救急科 affil-num=4 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=5 en-affil= kn-affil=岡山赤十字病院　呼吸器内科 affil-num=6 en-affil= kn-affil=岡山大学病院　救急科 affil-num=7 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=8 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=9 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=10 en-affil= kn-affil=岡山大学病院　救急科 affil-num=11 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 en-keyword=インフルエンザ Ａ (influenza A) kn-keyword=インフルエンザ Ａ (influenza A) en-keyword=H1N1 kn-keyword=H1N1 en-keyword=急性呼吸促迫症候群 (acute respiratory distress syndrome) kn-keyword=急性呼吸促迫症候群 (acute respiratory distress syndrome) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=5 article-no= start-page=1035 end-page=1036 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the influence of mineral ions on bacterial respiration Report II: The mutual action between mineral ions and such substances as inhibitor and antibiotics kn-title=抄録 抗Histamine剤のリンパ生成に対する作用，ならびにそれが二，三催リンパ物質の作用に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山崎英正 kn-aut-sei=山崎 kn-aut-mei=英正 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=前田寛 kn-aut-sei=前田 kn-aut-mei=寛 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=5 article-no= start-page=1023 end-page=1034 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the influence of mineral ions on bacterial respiration Report II: The mutual action between mineral ions and such substances as inhibitor and antibiotics kn-title=金属イオンの細菌の呼吸に及ぼす影響 第2篇 金属イオンと酵素阻害剤及び抗生物質との相互作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As reported before, washing of organisms results in the decrease of their respiration. The addition of mineral ions can restore that decrease, of which, however, the restorationis to a different extent according to the species of organisms and the sorts of substrates. This experiment is performed to study one aspect of the enzyme system of bacterial respiration, by observing the influence of inhibitors and antibiotics on this action of mineral ions. Organisms: Staphylococcus albus, Bacillus dysenteriae (Komagome B III) and Bacillus pyocyaneus. Substrates: Pyruvic acid, α-ketoglutaric acid, glutamic acid and α-glycerophosphoric acid. Mineral ions: Mg(++) and Fe(++) of four different concentrations. Inhibitors: KCN, D. N. P. and monoiodoacetic acid. Antibiotics: aureomycin, chloramphenicol and penicillin. 1) KCN: The inhibitory action of this substance is antagonized by the mineral ions of high concentration, of which Fe(++) is much more antagonistic than Mg(++). 2) D. N. P.: The inhibitory action of this substance is increased in the case where the bacterial respiration is also increased by the mineral ions. 3) Monoiodoacetic acid: This shows more inhibitory action in the case where the mineral ions are in high concentration. 4) Aureomycin: The inhibitory action of this antibiotic is remarkably antagonized by the mineral ions of high concentration. At the point where Mg(++) is the most effective, however, this shows the most noticeable inhibitory action. 5) Chloramphenicol: This shows little inhibitory action against the respiration of organisms and also has no relation with mineral ions. 6) Penicillin: This is effective to promote the respiration of organisms. It is even more effective in the presence of Mg(++) except in the case of Bacillus dysenteriae. However, its promotive action disappears in the presence of Fe(++). en-copyright= kn-copyright= en-aut-name=AkazawaHiroshi en-aut-sei=Akazawa en-aut-mei=Hiroshi kn-aut-name=赤沢広 kn-aut-sei=赤沢 kn-aut-mei=広 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=1105 end-page=1143 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on so called "Umayado Disease" 1. About its Etiological and Clinical items kn-title=「馬宿病」に関する研究 篇1. 疫学的,臨床的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have made researches on the kernel of an eruptive febrile disease which is usually seen, exceptionally in summer, at Aioi-mura, Okawa-gun, the eastern part of Kagawaken. The nature of this disease was unknown but I have succeeded in the isolation of Rickettsia from a patient, and made it clear that bacteriological natures and the Rickettsia isolated are identical with Rickettsia tsutsugamushi (orientalis). A similar disease in Tsuda-cho, Okawa-gun has been proved also to be Tsutsugamushi disease. while it can be seen in winter. This proves that there is a serious kind of Tsutsugamushi disease that develops in summer and a comparatively mild kind that develops in winter. The following shows the research I have made through clinical findings on each of the different types of tsutsugamushi disease. 1. Both Aioi-mura and Tsuda-cho are topographically located near the sea. It is usually the case that the patients houses are situated in lower land districts. 2. It develops only in summer in Aioi-mura with the duration of months from June to September. 3. It develops irrespective of age. In the block of Umayado (Aza Umayado) and Sakamoto (Aza Sakamoto) of Aioi-mura, I have found all the people, regardless of their ages, exposed in their home to the attack of the disease. 4. People of the contaminated areas are engaged in farming with fishing as their side job. Almost none of them raise pigs. This shows that pigs are not the cause of it. It is not as yet clear whether it is from the migratory birds. 5. No relation of cause and effect can be found between the occupation of the villagers snd the outbreak of the disease of the patients. 6. Clinical findings of the patients Mr. Mitani who had the disease in summer in Aioimura, and Mr. Tanizawa, in winter in Tsuda-cho are both found to be the same with those of Tsutsugamushi disease, and antibiotics especially the Terramycin is effective for it. Serums of the patients agglutinated the OXK remarkably, and assurance of the rising of the agglutination titers shows that it does not differ from the Tsutsugamushi disease. 7. The antibiotics especially the Chloromycetin and Terramycin are very effective. With these antibiotics the fever goes down. After the fever drops, it is difficult to isolate the Rickettsia from the blood. In brief, I have analyzed the clinical findings of de-velopment of "Umayado Disease", a local eruptive febrile disease, and at the same time, classified the peculiar local type of Tsutsugamushi disease according to the clinical findings into the summer type and the winter one. This leads to the fact that in a single prefecture and moreover at the places quite close to each other there can be seen a serious and a mild type of Tsutsugamushi disease in summer and winter respectively, which I think is sure to contribute to the study on the distribution and epidemic researches of Tsutsugamushi disease. en-copyright= kn-copyright= en-aut-name=NokiharaS. en-aut-sei=Nokihara en-aut-mei=S. kn-aut-name=軒原進 kn-aut-sei=軒原 kn-aut-mei=進 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=2083 end-page=2092 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of Rickettsia kn-title=Rickettsiaの代謝に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The auther tried the partial purification of rickettsiae proliferated in the embryonated egg yolk sacks, and measured the respiration of these partially purified rickettsiae by the usual manometric technique. The results are as follows: 1. By partial purification, it was possible to obtain more purified and not inactivated rickettsiae. 2. As a result of oxygen consumption measurement with Warburg manometer, glutamate, succinate and aspartate were strongly oxidized, and, at the same time, α-ketoglutarate, fumarate, malate, oxaloacetate, pyruvate and β-glycerophosphate were also oxidized pretty well. 3. All enzymic inhibitors showed some inhibition, of which most remarkable was that by monoiodoacetate. 4. The inhibitive action of various antibiotics is varied according to their concentration. However, aureomycin proved to show always very remarkable inhibition. 5. Though incomplete, Rickettsia tsutsugamushi has its proper metabolic system, and is inferred to keep its proliferation by completing its metabolic system in support or connection with living cells en-copyright= kn-copyright= en-aut-name=NakayamaTadao en-aut-sei=Nakayama en-aut-mei=Tadao kn-aut-name=中山忠夫 kn-aut-sei=中山 kn-aut-mei=忠夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=12 article-no= start-page=3009 end-page=3018 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiologic Studies on Venereal Diseases in Okayama District Report III. Statistical Observations on Venereal Diseases during past eight years (from 1949 to 1956) in the clinic of the Department of Dermatology and Urology, Okayama University Hospital kn-title=岡山地方における性病の疫学的研究 第3報 岡山大学医学部皮膚科泌尿器科教室過去8ケ年（昭和24年～31年）における性病の消長について en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper is presented the vicissitude of the venereal diseases, syphilis, gonorrhea, ulcus molle, ulcus mixtum and lymphogrannlomatosis venereum in past eight years from 1949 to 1956. In general, syphilis and gonorrhea have been decreased after the war, especially syphilis is marked and no patients visited in 1955 and 1956. This shows the influence of the effective use of the antibiotics, but seems to be obscured the latent type. en-copyright= kn-copyright= en-aut-name=YamamuraEitaro en-aut-sei=Yamamura en-aut-mei=Eitaro kn-aut-name=山村英太郎 kn-aut-sei=山村 kn-aut-mei=英太郎 aut-affil-num=1 ORCID= en-aut-name=IseiKunisuke en-aut-sei=Isei en-aut-mei=Kunisuke kn-aut-name=為政邦輔 kn-aut-sei=為政 kn-aut-mei=邦輔 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部皮膚科泌尿器科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=10 article-no= start-page=2505 end-page=2510 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Action of Various Inhibitors and Antibiotics on Glutamate-Respiration of Staphylococcus kn-title=ブドウ球菌のグルタミン酸呼吸に対する諸種阻害剤及び抗生物質の作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the action of various inhibitors and antibiotics on the glutamaterespiration of staphylococci under the consideration of physiological structure of the cell. Staphylococcus citreus and aureus (Terashima) were used as the test organisms, and L-glutamic acid as the substrate. The results were as follows: 1) Thionine, sodium arsenite and 8-hydroxyquinoline inhibited the respiration of intact cells of staphylococci markedly, but did not inhibit that of cell-free extracts. The inhibitive action of these three sorts of inhibitors was stronger on Staph. aureus (Terashima) than on Staph. citreus. 2) In intact cells, the inhibition of respiration by potassium cyanide and sodium azide was not restored by addition of thionine. In cell-free extracts, however, the inhibition by these two sorts of inhibitors was well restored by thionine. 3) By addition of thionine, the inhibition of the respiration of cell-free extracts by octanole was not so well restored as that by cyanide or azide. 4) 2, 4-Dinitrophenol inhibited the glntamate-respiration of both of the intact cells and cell-free extracts. 5) Of all the antibiotics tested, aureomycin was the only one which noticeably inhibited the glutamate-respiration of staphylococci. en-copyright= kn-copyright= en-aut-name=YabeYoshiro en-aut-sei=Yabe en-aut-mei=Yoshiro kn-aut-name=矢部芳郎 kn-aut-sei=矢部 kn-aut-mei=芳郎 aut-affil-num=1 ORCID= en-aut-name=AkitaKazuo en-aut-sei=Akita en-aut-mei=Kazuo kn-aut-name=秋田和男 kn-aut-sei=秋田 kn-aut-mei=和男 aut-affil-num=2 ORCID= en-aut-name=AkitaYoshimi en-aut-sei=Akita en-aut-mei=Yoshimi kn-aut-name=秋田悦示 kn-aut-sei=秋田 kn-aut-mei=悦示 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2157 end-page=2167 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Findings on the Glucose Metabolism of Resting Bacteria Part 2. Changes from Time to Time in the Optical Density of Supensions of Resting Bacteria kn-title=休止菌のglucose代謝に於ける二，三の知見 第二編 休止菌浮游液の透光度の時間的変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Realizing that the optical density of phosphate buffer suspensions of E. coli and Aerobacter aerogenes, Sal. typhi 57S and 57R, Staphylococcus aureus and albus at the wave length of 537 mμ changes at the time of glucose metabolism, changes of viscosity, viable counts, and the changes in the volumes of proteins, ribonucleic acid, desoxyribonucleic acid composing bacteria have been pursued and the results are as follows. 1. During the glucose metabolism of buffer suspensions using the bacteria mentioned above a rise of optical density can be observsd and the rise has usually a parallel concern with time incubated. 2. Accompanying the rise of the optical density the increase in the relative viscosity and increase of ribonucleic acid and proteins can be recognized. Assimilation and synthetic action can also be seen during the glucose metabolism. Changes of optical density have been found to be inhibited by antibiotics and thus this factor has been utilized in simple examination of antibiotics. en-copyright= kn-copyright= en-aut-name=FurutaniChieko en-aut-sei=Furutani en-aut-mei=Chieko kn-aut-name=古谷智恵子 kn-aut-sei=古谷 kn-aut-mei=智恵子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=825 end-page=831 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reciprocal Action of Antibiotics IV. The Reciprocal action of antibiotics to the drug-resistant strain of Salmonella typhi (S57S) kn-title=抗生物質の試験管内相互作用に関する研究 第四編 Streptomycin, Aureomycin, Chloromycetin耐性チフス菌S. 57 S株に対する各抗生剤の相互作用竝に交差耐性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this report, the author reports about the effect of combinative administrations of streptomycin, aureomycin and chloromycetin on the resistant strain of Salmonella typhi (S57S), and also about the relationship of cross-resistance among them: 1) To the 100γ/ml of streptomycin-resistant strain, the following combinative administrations are co-operative; streptomycin and aureomycin, streptomycin and terramycin, and streptomycin and chloromycetin. 2) To the 30γ/ml of aureomycin-resistant strain, the following combinative administrations are all co-operative; aureomycin and terramycin, aureomycin and streptomycin, and aureomycin and chloromycetin. 3) To the 10γ/ml of chloromycetin-resistant strain, the following combinative administrations are all co-operative; chloromycetin and streptomycin, chloromycetin and terramycin, and chloromycetin and aureomycin. 4) The streptomycin-resistant strain is not resistant to terramycin, aureomycin, and chloromycetin. 5) The aureomycin-resistant strain is not resistant to streptomycin, but is resistant to chloromycetin and terramycin. 6) The chloromycetin-resistant strain is not resistant to streptomycin, but is resistant to aureomycin and terramycin. en-copyright= kn-copyright= en-aut-name=SatoKimito en-aut-sei=Sato en-aut-mei=Kimito kn-aut-name=佐藤公人 kn-aut-sei=佐藤 kn-aut-mei=公人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=815 end-page=824 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reciprocal Action of Antibiotics III. The reciprocal action of antibiotics to the drug-resistant strain of Staphylococcus aureus (Terashima) kn-title=抗生物質の試験管内相互作用に関する研究 第三編 Penicillin, Streptomycin, Aureomycin, Chloromycetin耐性葡萄球菌寺島株に対する各抗生剤の相互作用竝に交差耐性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this report, the effect of combinative administrations of antibiotics on the drugresistant strains of Staphylococcus aureus (Terashima), and the acquisition of cross-resistance were also studied. The results are as follows: 1) To the 5 γ/ml and 10 γ/ml of penicillin-resistan strain, the following combinations are all co-operative; penicillin and streptomycin, penicillin and aureomycin, penicillin and terramycin, and penicillin and chloromycetin. 2) To the 50 γ/ml and 100 γ/ml of streptomycin-resistant strain, the following combinations are all co-operative; streptomycin and penicillin, streptomycin and chloromycetin, streptomycin and terramycin, and streptomycin and aureomycin. 3) To the 10 γ/ml of aureomycin-resistant strain, the following combinative administrations are all co-operative; aureomycin and penicillin, aureomycin and streptomycin, aureomycin and terramycin, and aureomycin and chloromycetin. 4) To the 5 γ/ml of chloromycetin-resistant strain, the following combinative administrations are all co-operative; chloromycetin and penicillin, chloromycetin and streptomycin, chloromycetin and terramycin, and chloromycetin and aureomycin. 5) The penicillin-resistant strain is not resistant to streptomycin, aureomycin, terramycin and chloromycetin. 6) The streptomycin-resistant strain is not resistant to penicillin, aureomycin, terramycin and chloromycetin. 7) The aureomycin-resistant strain is not resistant to penicillin, streptomycin and chloromycetin, but is resistant to terramycin. 8) The chloromycetin-resistant strain is not resistant to penicillin and streptomycin, but is resistant to aureomycin and terramycin. en-copyright= kn-copyright= en-aut-name=SatoKimito en-aut-sei=Sato en-aut-mei=Kimito kn-aut-name=佐藤公人 kn-aut-sei=佐藤 kn-aut-mei=公人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=809 end-page=813 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reciprocal Action of Antibiotics II. The reciprocal action of antibiotics to Salmonella typhi (S57S) kn-title=抗生物質の試験管内相互作用に関する研究 第二編 チフス菌S. 57 S株に対するStreptomycin, Aureomycin, Terramycin, Chloromycetinの試験管内相互作用について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied about the effect of the combinative administrations of each two of the following antibiotics, streptomycin, aureomycin, terramycin and chloromycetin; the tested combinations were 6 as a whole. Salmonella typhi (S57S) was used as a test organism. The results are as follows: 1) The antibacterial actions are co-operative to each other in each of the following combinations; streptomycin and aureomycin, streptomycin and terramycin, aureomycin and chloromycetin, chloromycetin and terramycin, and terramycin and aureomycin. 2) In the combination of chloromycetin and streptomycin, the action of chloromycetin is inhibited by streptomycin, while the action of streptomycin is enhanced by chloromycetin. 3) Among the group of the tested organism, the individual difference of resistance to antibiotics is observed. en-copyright= kn-copyright= en-aut-name=SatoKimito en-aut-sei=Sato en-aut-mei=Kimito kn-aut-name=佐藤公人 kn-aut-sei=佐藤 kn-aut-mei=公人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=801 end-page=808 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reciprocal Action of Antibiotics I. The reciprocal action of antibiotics to Staphylococcus aureus (Terashima) kn-title=抗生物質の試験管内相互作用に関する研究 第一編 黄色葡萄球菌寺島株に対するPenicillin, Streptomycin, Aureomycin, Terramycin, Chloromycetinの試験管内相互作用について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this report, the author reports about the effect of the combinative administrations of each two of the following antibiotics, penicillin, streptomycin, aureomycin, terramycin, and chloromycetin; the tested combinations were 10 as a whole. As a test organism, Staphylococcus aureus (Terashima) was taken. The results are as follows: 1) The antibacterial actions are co-operative to each other in each of the following combinations, penicillin and streptomycin, aureomycin and terramycin, aureomycin and chloromycetin, and chloromycetin and terramycin. 2) Though very slight, the antibacterial actions are co-operative in each of the following combinations, streptomycin and terramycin, streptomycin and aureomycin, and streptomycin and chloromycetin. 3) In each of the combinations of penicillin with chloromycetin, terramycin, and aureomycin, the antibacterial action of penicillin is inhibited by the other, while each action of chloromycetin, terramycin, and aureomycin is enhanced by penicillin. 4) Among the groups of tested organism, the individual difference of resistance to antibiotics is observed. en-copyright= kn-copyright= en-aut-name=SatoKimito en-aut-sei=Sato en-aut-mei=Kimito kn-aut-name=佐藤公人 kn-aut-sei=佐藤 kn-aut-mei=公人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=549 end-page=560 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Glutamic Acid Metabolism of Bacteria II: Glutamic acid metabolism of Staphylococcus albus kn-title=細菌のグルタミン酸代謝に関する研究 第二篇 白色ブドウ球菌のグルタミン酸代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As to the physiological or metabolic features of pathogenic staphylococci, there are only a few reports, compared with those of Escherichia coli which was treated in report I. In this report, the author reports about the physiological aspects, particularly about the terminal respiratory system of Staphylococcus albus, entering from the studies of glutamic acid metabolism: 1) Staph. albus has the so-called citric acid cycle as its terminal respiratory ststem. 2) As a result of oxidative deamination, glutamic acid enters into the citric acid cycle and is further oxidized through this cycle. Glutamic acid is, however, best oxidized of all the intermediates of citric acid cycle and the related compounds. 3) Glutamic-aspartic and glutamic-alanic transaminations are carried out by this organism, in which glutamic acid plays the central role. 4) Divalent metal ions (Mg(++), Mn(++) and Fe(++)) show no remarkable effect on the glutamate-respiration of Staph. albus. 5) Of the various inhibitors tested, sodium azide, 2: 4-dinitrophenol, sodium arsenite and 8-hydroxyquinoline inhibit the glutamate-respiration strongly, and the most remarkable is the inhibitive action of 8-hydroxyquinoline. 6) Of the various antibiotics used, the inhibitive action of aureomycin is the most remarkable. Penicillin also shows some inhibitive action at pH 5.4. 7) The inhibition of the glutamate-respiration of this organism by these various inhibitors and antibiotics shows usually the tendency to rise up in the region of lower pH. en-copyright= kn-copyright= en-aut-name=AkitaYoshimi en-aut-sei=Akita en-aut-mei=Yoshimi kn-aut-name=秋田悦示 kn-aut-sei=秋田 kn-aut-mei=悦示 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Studies on the Parametritis and Peritonitis developing during Radiological Treatment in Cancer of the Uterine Cervix (Data of 21 years from 1934 to 1954 at the Dept. of Obstet. & Gynec., Okayama University) kn-title=子宮頸癌放射療法中の骨盤結合織炎並びに腹膜炎の統計的観察（岡山大学産婦人科教室に於ける昭和9年～29年迄の調査成績） en-subtitle= kn-subtitle= en-abstract= kn-abstract=During twenty one years from 1934 to 1954, there were 1,974 patients of radiation therapy in the gynecological department of Okayama University. The authors made statistical observations on parametritis and peritonitis which developed during and after radiological treatment. Results obtained were as follows:- Parametritis, 211 cases (10.69%), peritonitis 132 cases (6.69%). The occurrence was higher in the war time (1943 to 1949), and thereafter it has gradually been decreasing in number. The onset started evidently often after the biginning of the radium treatment. It was clear that the patients were frequently observed in cases of advanced cancer, and the occurrence was higher in the patients less than 50 years of age. On the blood count, peritonitis had high incidence in cases of leucocytosis over 8,000 and showed high incidence in cases of high blood sedimentation rate (more than 100 mm an hour), and both had low incidence in the low rate (less than 39 mm an hour). It will be said that better effect is expectable by means of prophylaxis and adequate treatment of those inflammatory conditions using recently advanced antibiotics. en-copyright= kn-copyright= en-aut-name=SugaHazime en-aut-sei=Suga en-aut-mei=Hazime kn-aut-name=須賀肇 kn-aut-sei=須賀 kn-aut-mei=肇 aut-affil-num=1 ORCID= en-aut-name=MitutaniSiro en-aut-sei=Mitutani en-aut-mei=Siro kn-aut-name=満谷士郎 kn-aut-sei=満谷 kn-aut-mei=士郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=37 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STUDIES ON THE RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO STREPTOMYCIN kn-title=結核菌のストレプトマイシン耐性に関する研究 第2編 ストレプトマイシン耐性結核菌の耐性持続性並びに緩解に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 1887, Kossiakoff first described the phenomenon of drug-resistance of bacteria. Recently with the wide-spread use of streptomycin and other various antibiotics in the field of therapeutics, this phenomenon of drug-resistance has become very important in clinical medicine. As to streptomycin alone, which was discovered in 1944 by Waksmann and brought the epoch-making progress to the therapy ef tuberculosis, the acquisition of resistance is one of the problems which need great precautions at the execution of streptomycin-therapy. Since 1946 when Luria and Delbrück first reported about the mechanism of acquisition of resistance to sulfonamide, the mechanism of acquisition of resistance to streptomycin and other antibiotics and that of reversion from it have been hotly argued. No decidedly substantiating results, however, have yet been obtained, though two confronting theories, spotaneous mutation theory and adaptation theory, are now advocated. The former is the theory which asserts that the acquisition of resistance is originated in their spontaneous mutation happening during the process of proliferation and in the selective action of drugs; this theory has nowadays many sustaining scholars. In the latter theory, the direct action of drugs to the rise of resistance is considered as the mehanism of the acquisition of resistance. Now that this phenomenon of drug-resistance is demonstrated to be the genetic variation with heredity and its mode of transmission is also clarified by Lederberg and Newcombe, it is difficult to explain the mechanism of acquisition of resistance according to the adaptation theory only. In the adaptation theory, however, refering to the idea of “Dauermodifikation” described on paramecium by Jollos in 1921, they have become to consider that antibiotics have the mutagenicity which seems to be the direct cause of the acquisition of drug-resistance. Since 1952, the author has carried out many experiments to study the essential features of streptomycin-resistant tubercle bacilli in vitro and in vivo, according to the "theory of spontaneous mutation with selection" which is supported by many researchers. The results are as follows: 1) Wolinsky reported that mutants over 0.1% of the original streptomycin-sensitive tubercle bacilli were observed on the culture media containig 1000γ/cc of streptomycin. In the present reports, the author studied the development of resistance by succesive cultures of the strains newly isolated from the tnberculosis patients who had received no or little streptomycin-therapy, and observed the spontaneous mutants over 0.1% of 0.1 mg and 1 mg of the inoculated bacilli. 2) Akiba et al. reported that, besides the spontaneous mutation, streptomycin itself had some effect on the mutation of gene. In the present work, many facts were observed which were hardly explained by “spontaneous mutation with selection” only. For example, the author also isolated one strain which seemed to be caused by such cause as that Akiba et al. reported. 3) There are many reports that the resistance of streptomycin-resistant tubercle bacilli is stable and long-lasting. The author performed many experiments in vitro and in vivo to study the development of the resistance of highly resistant strain over 1000γ/cc, of middle grade-resistant one over 100γ/cc and of low grade-resistant one under 10γ/cc. As a result of these experiments, the falling tendency of resistance was clearly observed in not only low and middle grade-resistant but also in highly resistant strains. en-copyright= kn-copyright= en-aut-name=NozakiTatsuo en-aut-sei=Nozaki en-aut-mei=Tatsuo kn-aut-name=野崎達夫 kn-aut-sei=野崎 kn-aut-mei=達夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-2 article-no= start-page=8319 end-page=8324 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reduction Process of Bilirubin in the Intestine Part 2 Studies on the reduction of bilirubin by the fecal filtrate of the patient with the administration of antibiotics kn-title=腸管内bilirubinの還元過程に関する研究 第2編 抗生剤内服患者の屎濾液を以てするbilirubinの還元について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The separation of bilirubinoide in the anaerobic cultured solution of bilirubin with the fecal filtrate of the patient taking antibiotics and the cultured solution of the above fecal filrate in the phosphate pepton solution for 24hours under the anaerobic condition was attempted. And the results were as follows. 1. Indirect, direct bilirubin and mesobilirubin were separated at the 12th hour, same products at the 24th hour, dihydromesobilirubin and the above products at the 36th hour and urobilin and the above products at the 48th hour after the action of fecal filtrate to bilirubin, but only urobilin was identified after 72hours. 2. Indirect-, direct bilirubin, dihydromesobilirubin were separated at the 12th hour, indirect bilirubin and mesobilirubin at the 24th hour, dihydromesobilirubin at the 36th hour, and indirect bilirubin, mesobilirubin, dihydromesobilirubin and urobilin at the 48th hour after the anaerobic incubation of bilirubin with the cultured solution of a small amount of fecal filtrate in the phosphate pepton solution, but only urobilin was identified after 72hours. 3. Bilirubin was reduced to urobilinogen pasing though mesobilirubin, dihydromesobilirubin by anaerobic bacterial flora and it's reduction process was same to the reduction process of bilirubin by colloidal palladium, clarified by H. Fischer. en-copyright= kn-copyright= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-2 article-no= start-page=8313 end-page=8318 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reduction Process of Bilirubin in the Intestine Part 1 Studies on the separation of bilirubinoide in feces kn-title=腸管内bilirubinの還元過程に関する研究 第1編 屎中bilirubinoideの分離について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bilirubinoide in the feces of various patients was separated by column chromatography. And the results were as follows. 1. Bilirubin and urobilin could be separated from the feces of various patients, but other bilirubinoide was only identified by the absorption curves because of the scanty dosis. 2. Bilirubin, mesobilirubin, dihydromesobilirubin and urobilin were separated from the feces of 6 cases in the 8 cases with the administration of antibiotics for a long period, and bilirubin, dihydrobilirubin, mesobilirubin and urobilinogen in other one case and bilirubin, dihydromesobilirubin in another case. 3. In the above 2 cases with the administration of antibiotics, mesobilirhodin and mesobiliviolin were identified in the mixture of urobilin, but each fraction of them could be scarcely separated. Since dihydromesobilirubin was separated at that time, it was thought that mesobilirhodin and mesobiliviolin were produced by the oxydation of dihydromesoblilirubin during the separation process. Therefore, it was thought that dihydromesobilirubin produced in the intestine was composed of two isomerides. 4. The formation of urobilinogen in the intestine was supposed to take the same reduction process of bilirubin by colloidal palladium in vitro. en-copyright= kn-copyright= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-1 article-no= start-page=7379 end-page=7388 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Studies on Lung Moniliasis Part II Studies on Secondary Lung Moniliasis kn-title=肺カンジダ症の臨床的研究 第2編 続発性カンジダ症について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The 4 cases with the diagnosis of secondary lung and bronchial moniliasis were fully investigated and the difference between primary and secondary lung moniliasis was studied: And the results were as follows. 1. Secondary lung and bronchial moniliasis was apt to be concealed under the main disease, but it showed as same as the symptom of primary lung moniliasis. 2. The loss of individual resistence was naturally considered for the pathogenesis of secondary lung and bronchial moniliasis and the effect of antibiotics was also considered. 3. The fixed dosis of sarkomycin restrained the growth of candida albicans in vitro and vivo. en-copyright= kn-copyright= en-aut-name=SatoAkira en-aut-sei=Sato en-aut-mei=Akira kn-aut-name=佐藤熙 kn-aut-sei=佐藤 kn-aut-mei=熙 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=7047 end-page=7056 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reduction of Bilirubin by Fecal Flora Part 1 A Study on the Bile Pigment Fraction in the Bile with the Positive Ehrlich's aldehyde reaction kn-title=腸内細菌叢によるbilirubinの還元に関する研究 第1篇 Ehrlich's aldehyde反応陽性を呈する胆汁中の胆汁色素分劃の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mesobiliviolin reaction and the intermediate products of bilirubin were observed on the B-bile, with the positive Ehrlich's aldehyde reaction, odtained from 20 cases of cholecystopathy, and the results were as follows. 1. After mesobiliviolin reaction on 19 cases the chloroform extract was separated into each pigment by column chromatography, and the absorption curves of each pigment and their changes on the addition of a saturated alcoholic solution of zine acetate were observed. 2. The question whether or not stercoblinogen occupies the position superior to mesobilinogen can be explained by the intensity of bile duct infection, especially the infection by B. coli, or by the intensity of the inflammation findings of bile duct. 3. From the 4 cases treated with antibiotics stercobilinogen could not be detected but only mesobilinogen, suggesting that antibiotics reduce the chemical activity of bacteria. 4. In 4 cases bilirubin and mesobilirubin could be detected and also a pigment that apears to be dihydromesobilirubin. From these results it bas been clarified that the in vivo reduction of bilirubin to urobilinogen is not conducted by liver enzymes but by bacterial enzymes. 5. On 2 cases the detection of d-urobilin was attempted by means of polarimeter and dioxan-HCl boiling method, but the existence of this pigment could not be observed. en-copyright= kn-copyright= en-aut-name=MitsudaToshihiro en-aut-sei=Mitsuda en-aut-mei=Toshihiro kn-aut-name=光田利弘 kn-aut-sei=光田 kn-aut-mei=利弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6843 end-page=6856 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Influences of Bacterial Infection in Infected Hydronephrosis kn-title=感染性水腎症に於ける細菌感染の影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author observed the development of infected hydronephrosis on rabbits infusing colibacillus or staphylococcus flavus into their vein or calix after the ligation of their ureter (left side). The author also obsesved the effects of antibiotics on hydronephrosis using the injection of Penicillin, Achromycin, Chloromycetin and Streptomycin into these rabbits, and the results were as followed. 1. Hydronephrosis occurred in highly percentage about 10-12 days after the infusion in vein and about 21 days after the infusion in calix in the cases of the ligation of ureter. Infusing staphylococcus in vein and colibacillus in calix, the development of hydronephrosis was accelerated. 2. The antibiotics prevented the enlargement of kidney considerably, and the preliminary application of antibiotics before the infusion was most effective. en-copyright= kn-copyright= en-aut-name=SeraMasaho en-aut-sei=Sera en-aut-mei=Masaho kn-aut-name=世良昌穂 kn-aut-sei=世良 kn-aut-mei=昌穂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=1 article-no= start-page=1 end-page=5 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Identification of Ornithine-lactam Converted from Arginine in Streptomyces incarnatus NRRL8089 kn-title=シネフンギン生産菌Streptomyces incarnatus NRRL 8089由来アルギニン変換化合物「オルニチンラクタム」の同定 en-subtitle= kn-subtitle= en-abstract=シネフンギンは抗真菌，抗マラリア活性を有する核酸系抗生物質であり，放線菌 S. incarnatus により生合成される．シネフンギンはアデノシンとオルニチンがＣﾝＣ結合した構造であり，無細胞抽出液での取り込み実験からＬﾝアルギニンと ATP から生合成されると推測される．Ｌﾝアルギニン，Ｌﾝオルニチンを S. incarnatus の休止菌体反応系への投与を行いシネフンギン中間体の探索を行った．その結果50ﾋアルギニンは24時間以内に低極性化合物へと変換された．一方50ﾋオルニチンは変換されず反応液中に残存した．HPLC で化合物を精製し，1HﾝNMR，FABﾝMS での分析の結果オルニチン環状モノペプチド，「オルニチンラクタム」（分子量114）であることを明らかにした．この結果は S. incarnatus がアルギニンからオルニチンラクタムへの変換酵素を有する事を示唆する．このような酵素の報告例はこれまでになく，ニ次代謝酵素であることが示唆され，シネフンギン生合成との関連性に興味が持たれる． kn-abstract=Sinefungin is a nucleoside antibiotic, in which a molecule of L-ornithine is linked to the 5' end of adenosine through a C-C bond. The antibiotic was isolated from the culture broth of Streptomyces incarnatus. For the purpose of detecting intermediate of sinefungin biosynthesis, resting cell suspensions were incubated with supplemental L-arginine, and L-ornithine. 50mM Arginine was converted to a compound X that has low polarity. 50mM ornithine was not converted and remained in reaction solution. Compound X was purified using HPLC, and analyzed using (1)H-NMR and FAB-MS. These analyses showed that a compound X is "ornithine-lactam" (Mw＝114), which has a structure of circularized ornithine. These results indicated that S. incarnatus has an enzyme that converts arginine to ornithine-lactam. Such an enzyme has never been reported, and suggested that it may be relevant to sinefungin biosynthesis. en-copyright= kn-copyright= en-aut-name=FukudaKoji en-aut-sei=Fukuda en-aut-mei=Koji kn-aut-name=福田康二 kn-aut-sei=福田 kn-aut-mei=康二 aut-affil-num=1 ORCID= en-aut-name=TamuraTakashi en-aut-sei=Tamura en-aut-mei=Takashi kn-aut-name=田村隆 kn-aut-sei=田村 kn-aut-mei=隆 aut-affil-num=2 ORCID= en-aut-name=InagakiKenji en-aut-sei=Inagaki en-aut-mei=Kenji kn-aut-name=稲垣賢二 kn-aut-sei=稲垣 kn-aut-mei=賢二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=sinefungin kn-keyword=sinefungin en-keyword=arginine kn-keyword=arginine en-keyword=ornithine kn-keyword=ornithine en-keyword=Streptomyces kn-keyword=Streptomyces END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4511 end-page=4520 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physiological Studies on Drug-Resistant Bacteria 2. Physiological Study on Aureomycin-Resistant Escherichia coli kn-title=抗生物質耐性菌の生理学的研究 第2編 オーレオマイシン耐性大腸菌の生理学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been reported that, in microorganisms, the acquisition of resistance to aureomycin is relatively difficult compared with the other antibiotics. Physiological studies on the aureomycin-resistant bacteria are also few as compared with those on the bacteria resistant to the other antibiotics. The author isolated a strain of Escherichia coli resistant to aureomycin, and studied on some physiological aspects of this strain in comparison with the sensitive strain. The results are summarized as follows: 1) In the culture of this aureomycin-resistant strain, there appeared a number of string-like cells, which might be considered to be produced by inhibition of cell division. No marked change could be observed in the characters of the colony and the staining of this strain. 2) Without addition of aureomycin, no difference was observed between the multiplication of this resistant strain and that of the sensitive stain. In the media containing aureomycin, however, the resistant strain showed a resistance to aureomycin about 10 to 100 times that of the sensitive strain. 3) In the absence of aureomycin, no marked difference existed between the respiratory activity of the resistant strain and that of the sensitive strain. In the presence of aureomycin, however, the respiratory activity of the resistant strain showed a resistance to aureomycin about 3 times that of the sensitive strain. 4) In the inhibitive action of aureomycin to the oxidation of lactate by the cell-free extract, no noticeable difference was observed between the resistant and the sensitive strains. These results suggest that the change of the cytoplasmic membrane of the resistant strain plays the most important role for exhibition of its high resistance to aureomycin. en-copyright= kn-copyright= en-aut-name=HayashiSei en-aut-sei=Hayashi en-aut-mei=Sei kn-aut-name=林生 kn-aut-sei=林 kn-aut-mei=生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=11 article-no= start-page=4275 end-page=4284 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Phosphorus Metabolism of Bacteria by Radioactive P(32) Part 2 The effect of metal-ions and antibiotics on the P(32) incorporation kn-title=Radioisotope P(32)による細菌燐代謝の研究 第二編 P(32)摂取量に及ぼす金属イオン, 抗生物質の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using Radioactive P(32) as a Tracer, the author studied the effect of bivalent metal-ions and antibiotics on the phosphorus intake of Salmonella 57S, Salmonella 57R, Staphylococcus aureus, and Staphylococcus albus of the departmental stock. And the following results were obtained. 1). It was observed that Mg⁺⁺ and Fe⁺⁺ ions tend to increase the phosphorus intake of these organisms. Therefore these ions should have relation to oxidative phosphorylation. However, it was noticed that Mg⁺⁺ ion had more powerful effect on Salmonella 57S, and Salmanella 57R, contrarily Fe⁺⁺ ion had that on Staphylococcus aureus and Staphylococcus albus. 2). Although aureomycin showed inhibitory effect on the phosphorus intake of the organisms, chloromycetin and penicillin did not show the effect. 3). From the result of phosphorus fractionation, the greater part of P(32) deposit in the cells took in the respiratory state was incorporated in the acid-soluble organic phosphorus faction. 4). Concerning about the effect of aureomycin on the P(32) incorporation in each fractions, it was found strong inhibitory effect of aureomycin on the incorporation of P(32) in the acidsoluble organic phosphorus fraction. But the effect on the incorporation in other fractions could not be observed. en-copyright= kn-copyright= en-aut-name=TakeharaMinoru en-aut-sei=Takehara en-aut-mei=Minoru kn-aut-name=竹原実 kn-aut-sei=竹原 kn-aut-mei=実 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=8 article-no= start-page=2749 end-page=2759 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fundamental Studies on the Effect of Several Anti-Tuberculous Agents Part 3. Fundamental Study with Viomycin kn-title=数種抗結核剤の薬剤効果に関する基礎的研究 第三編 Viomycinの基礎実験 附. 全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The detailed report on viomycin (VM), the second anti-tuberculous antibiotics next to SM, is rare, and none at all on its use in combination with INAH or with INHG. Therefore, the author performed the in vitro experiments, acute toxicity tests, and VM treatment against mouse tuberculosis, and obtained the following results. 1. VM solution at the concentration of 15.0 inhibits the growth of tuberculous bacilli, and it acts against SM-resistant strain identically as against the SM-susceptible strain. 2. However, VM used in combination with SM, INAH, or INHG, acts as to assist one another, while VM combined with PAS has no effect at all. 3. LD(50) of VM in the case of subcutaneous injection to mouse is 1,626 mg/kg (±157.64 mg/kg). 4. For the mouse berculosis the effect of VM alone is weak, while VM and SM nsed in equal amount separately the effect of VM is about one half that of SM alone. 5. The use of VM comb ned with INAH or INHG is super ro to the effect of VM used alone, showing no significant difference from that of INAH or INHG used alone thus proving the addition of VM is ineffective. From these it is assumed that VM is effective to tuberculosis in the case only when the causative strain has the resistance against SM or INAH. en-copyright= kn-copyright= en-aut-name=YoshikawaKiyoshi en-aut-sei=Yoshikawa en-aut-mei=Kiyoshi kn-aut-name=吉川潔 kn-aut-sei=吉川 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2541 end-page=2545 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Precipitate Formation by Metal Ions and Antibiotics, Particularly Tetracycline Substances kn-title=抗生物質, 殊にテトラサイクリン系物質と金属イオンによる沈澱形成 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many investigators have reported on the influence of various metal ions on antibiotics. The direct evidence for binding of metal ions with antibiotics is, however, very rare. The authors happened to find the precipitate formation by Mg⁺⁺ ion and aureomycin, and studied this phenomenon on various sorts of metal ions and antibiotics. The results are summarized as follows: 1) A marked yellow precipitate was formed by 10⁻² 10⁻³ M Mg⁺⁺ and 10⁻³-10⁻⁴M aureomycin. 2) A yellow precipitate was formed by 10⁻³M Mn⁺⁺ and 10⁻³-10⁻⁴M aureomycin, and was also formed by 10⁻⁴M Mn⁺⁺ and 10⁻³M aureomycin. 3) Just, like aureomycin, terramycin formed a yellow precipitate in the presence of Mg⁺⁺ or Mn⁺⁺. The degree of precipitate formation was, however, very weak as compared with aureomycin. 4) The precipitate formation between Mg⁺⁺ and aureomycin appeared at the pHs over 6.5 and became more marked with the rise of pH. 5) The acid solution of the yellow precipitate formed by Mg⁺⁺ and aureomycin showed a strong antibacterial action. en-copyright= kn-copyright= en-aut-name=YabeYoshiro en-aut-sei=Yabe en-aut-mei=Yoshiro kn-aut-name=矢部芳郎 kn-aut-sei=矢部 kn-aut-mei=芳郎 aut-affil-num=1 ORCID= en-aut-name=HayashiSei en-aut-sei=Hayashi en-aut-mei=Sei kn-aut-name=林生 kn-aut-sei=林 kn-aut-mei=生 aut-affil-num=2 ORCID= en-aut-name=NakayamaGoro en-aut-sei=Nakayama en-aut-mei=Goro kn-aut-name=中山五郎 kn-aut-sei=中山 kn-aut-mei=五郎 aut-affil-num=3 ORCID= en-aut-name=OhnishiHiroyuki en-aut-sei=Ohnishi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=1 article-no= start-page=23 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the pseudomembranous laryngotracheitis after the endotracheal anesthesia. Part Ⅲ. Prophylaxis and therapy kn-title=気管内麻酔後の偽膜性喉頭気管炎に関する研究 第3編 予防並に治療について en-subtitle= kn-subtitle= en-abstract= kn-abstract=To prevent the pseudomembranous laryngotracheitis cares should first be taken against infection complete sterilisation of the tube and choosing suitable size of the tube, administration of antibiotics before operation, avoiding the trauma of mucous membrane of the trachea by tube, keeping the cuff pressure necessarily minimum and choosing the kind of the lubricant may be necessary. Namely to choose the tube, the lateral view of X-ray is profitable and the cuff pressure about 30 mmHg may be suitable by low tension cuff. For the lubricant xylocainjerry is most useful and administration of antibiotics may be more effective. Using the above mentioned condition we performed experimentally 20 cases of endothracheal anesthesia and found no pseudomembranous laryngotracheitis at all. In preliminary experiment the pressure of the cuff upon the wall of the trachea and the relationship of the cuff pressure to the space between the tube and the trachea were studied. en-copyright= kn-copyright= en-aut-name=HisamochiHideomi en-aut-sei=Hisamochi en-aut-mei=Hideomi kn-aut-name=久持秀臣 kn-aut-sei=久持 kn-aut-mei=秀臣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=4-6 article-no= start-page=441 end-page=453 dt-received= dt-revised= dt-accepted= dt-pub-year=1961 dt-pub=19610630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effects of Various Anti-Leukemic Agents by Means of Sternal Bone Marrow Tissue Culture of Various Leukemic Patients Part 2. On the Effects of Various Antibiotics and OX Substance by Clinical Tissue Culture of Bone Marrow kn-title=各種白血病患者胸骨骨髄培養に於ける各種抗白血病剤の影響に関する研究 第Ⅱ編 臨床組織培養による抗生物質及びOX物質の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to elucidate the effects of various antibiotics (carzinophilin, actinomycin C, chromomycin, mitomycin) and OX substance on the function of leukemic cells, the author performed clinical tissue culture of bone marrow of various leukemic patients. First the author performed bone marrow tissue culture of normal persons with addition of various antibiotics and OX substance in graded concentrations and established the maximal concentration of the agents in the medium, which does not impede the bone marrow cell growth. The author observed the effect of direct addition of various antibiotics and OX substance at this maximal concentration on the relative growth of the tissue, the wandering velocity of the cells, and the cell density in the bone-marrow tissue culture of various leukemic patients; and obtained the following results: 1. In acute myelogenous leukemia chromomycin and actinomycin C acted somewhat inhibitorily on the cell growth of the bone marrow. 2. In chronic myelogenous leukemia the inhibitory effect was found, though only slightly, to be in the descending order of carzinophilin, mitomycin, chromomycin and OX substance. 3. In acute lymphocytic leukemia and in chronic lymphocytic leukemia, no agents acted inhibitorily on the cell growth of the bone marrow. 4. In monocytic leukemia mitomycin showed an inhibitory effect to a moderate degree. 5. Judging from the effects of these drugs on leukemic cells, it may be expected that the efficacy of these drugs in the treatment of various leukemias is as follows: In actue myelogenous leukemia chromomycin is mildly effective; in chronic myelogenous leukemia carzinophilin is also mildly effective; and in monocytic leukemia mitomycin mildly effective. en-copyright= kn-copyright= en-aut-name=NabeshimaSaburo en-aut-sei=Nabeshima en-aut-mei=Saburo kn-aut-name=鍋島三朗 kn-aut-sei=鍋島 kn-aut-mei=三朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=267 end-page=275 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Immunization of Mice by Rickettsia tsutsugamushi Ⅰ: Studies on the influence of Antibiotics on Antigen Production in Mice Infected with Rickettsia tsutsugamushi kn-title=恙虫病病毒感染ハツカネズミに成立する免疫の本態に関する研究 第1編 恙虫病病毒感染ハツカネズミの抗体産生に及ぼす抗生物質等の影響に関する実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In respect to the dose of antibiotics and the period of administration, the author studied the influence of antibiotics on antibody production in mice infected with Rickettsia tsustugamushi. Chloramphenicol was used as the test antibiotic, and the antibody production was estimated by the Weil-Felix reaction and cellular figure of the ascites. The results were as follows: 1) When chloramphenicol was given to mice in the begginning period, 24 hours after inoculation of R. tsutsugamshi, the antisera of mice showed a positive agglutination reaction to 20× to 40× dilution. 2) When chloramphenicol was given to mice in the later period, 8 days after inoculation of R. tsutsugamushi, the antisera of mice showed a positive agglutination reaction to 80× to 120× dilution; a almost similar result in the control group of mice not given chloramphenicol, 3) The agglutination titer of antisera was a little higher in the mice continuously administered small doses of chloramphenicol than in those administered once a big dose. 4) In the group of mice given chloramphenicol in the begginning period, the cellular examination of the ascites revealed the increase of histiocytes and monocytes, and the slight decrese of serous cells and lymphocytes. In those given chloramphenicol in the later period, the increase of serous cells, lymphocytes as well as histiocytes was observed; nearly the similar cellular figure to those in mice receiving no chloramphenicol administration. From these results, it is considered that the administration of chloramphenicol has a very great influence on the production of antibody. en-copyright= kn-copyright= en-aut-name=MitsuiMasao en-aut-sei=Mitsui en-aut-mei=Masao kn-aut-name=三井正雄 kn-aut-sei=三井 kn-aut-mei=正雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=2111 end-page=2132 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serological Studies on Aspergillosis Part Ⅳ Studies on prevention of mycosis kn-title=Aspergillosisの血清学的研究 第Ⅳ編 発症防禦に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As for the treatment of mycosis, there are reported many therapeutical method using antibiotics, chemotherapeutics, vaccine or immune serum; however, there is no report on the basis of prevention of mycosis as yet. The author assumed that the situation might be caused by uncertainity on the mechanism of manifestation of the symptome and that the lung affection, that reported already on the Part Ⅰ of this thesis, was resulted from repeated and large-amounted invasion of the fungus into body. The author studied mass invasion of Aspergillus and found the specific histological change on lung following by 1 or 2 large-amounted inhalation of the fungus to mouse. Also the author observed the preventive effect of the filtrate of the broth into which Asp. oryzae was cultred and the polysaccharide prepared from prepared from pellicle of the organism in the light of the lethality and specific change on tissue. The filtrate and the polysaccharide were given to mouse subcutaneously 1-3 times before the inhalation. en-copyright= kn-copyright= en-aut-name=SeoMasakatsu en-aut-sei=Seo en-aut-mei=Masakatsu kn-aut-name=瀬尾昌克 kn-aut-sei=瀬尾 kn-aut-mei=昌克 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川県衛生研究所 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=915 end-page=919 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Comparative Study on the Tryptophan Metabolism of Streptomycin-sensitive and Streptomycin-resistant Shigella flexneri kn-title=赤痢菌のストレプトマイシン耐性変異とトリプトフアン代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There has been very little experimental work on the tryptophan metabolism of streptomycin-resistant bacteria. The authors performed this experiment in order to find out the differencies of the tryptophan metabolism between streptomycin-sensitive and streptmycin-resistant Shigella flexneri 2a. The results were as follows: 1. When streptomycin-resistant strains were grown in the streptomycin-containing medium, they have quantitatively lower tryptophanase activity than streptomycin-sensitive strains. 2. Streptomycin-resistant strains restores tryptophanase activity when streptomycin is absent in the growth medium, but they are resistant to streptomycin (10,000γ/ml). 3. Tryptophanase activity of both strains is inhibited slightly by divalent metal ions such as Mg, Fe, and Mn, but the inhibitive action of Cu is very remarkable. Natrium azide and arsenite have no effect. Vitamin B(6) and 2.4-dinitrophenol accerelates indole production from tryptophan by this organism. 4. Of the the various antibiotics aureomycin inhibits most markedly tryptophanase activity and chloromycetin does slightly, but streptomycin has no influence. 5. Tryptophanase is an adaptive enzyme, and considered to have essentially no relation to streptomycin-resistant mutation. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=NishiiEmiko en-aut-sei=Nishii en-aut-mei=Emiko kn-aut-name=西井笑美子 kn-aut-sei=西井 kn-aut-mei=笑美子 aut-affil-num=2 ORCID= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=HonmatuKakushi en-aut-sei=Honmatu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=3-4 article-no= start-page=479 end-page=483 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Encephalomyelitis with Abdominal Signs Observed at a Hospital in the Okayama Prefecture Part 2. Treatment by Drugs, Especially Vitamine B1, B6 and B12 Complex kn-title=岡山県下一病院で観察した腹部症状を伴う脳脊髄炎症について 第二報 薬物治療，特にビタミンB1，B6，B12複合剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Drugs of adrenal corticosteroid and vitamin complex of B1, B6 and B12 were therapeutically administered on 21 cases out of the total 23 cases diagnosed as encephalomyelitis with abdominal disturbances in the Ibara districts from January, 1966 till August, 1967. Complementarily, administrations of antibiotics, ACTH, ATP, thioctic acid, etc. were added. 1. Treatment by adrenal corticosteroid improved both abdominal signs and nervous disorders in 48% of the cases. Such effects were also observed in cases showing recurrence. 2. Administration of vitamine B1, B6 and B12 complex was effective to improve the nervous disorders, such as sensory or locomotor disturbances, in about 30% of the cases, although ineffective on the abdominal, signs. The therapeutical effect of the vitamine complex, therefore, was lower than that of corticosteroid. However, in some cases showing no effect by corticosteroid treatment, symptoms were improved by administration of the vitamin complex. The complex was ineffective on cases showing recurrence. en-copyright= kn-copyright= en-aut-name=TakakiShin en-aut-sei=Takaki en-aut-mei=Shin kn-aut-name=高木新 kn-aut-sei=高木 kn-aut-mei=新 aut-affil-num=1 ORCID= en-aut-name=HirotaShigeru en-aut-sei=Hirota en-aut-mei=Shigeru kn-aut-name=広田滋 kn-aut-sei=広田 kn-aut-mei=滋 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=井原市民病院内科 affil-num=2 en-affil= kn-affil=井原市民病院内科 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=1-2 article-no= start-page=87 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on the pattern of urinary protein excretion of college student discovered proteinuria by periodical examination kn-title=定期健康診断における尿蛋白陽性者の尿蛋白排泄patternによる検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sixty-eight of Okayama university students who discovered by periodical examination was investigated by five urine specimen method, and classified in nine groups by the pattern of proteinuria. Simultaneously, past history, urinary sediment, hematocrit, PSP, Urea-N and total serum protein was investigated and comparative studies among each group was studied. Percentage of positive proteinuria discovered by two urine specimen examination (before bed and early morning) and three urine specimen examination (on arrival, one hour rest and two hours rest) was not coincided, so these results suggest the more urine examination make the better discovery of proteinuria, because intermitent proteinuria was 27.4% who showed negative urinary protein on the examined day. Type of urinary protein excretion pattern was classified as follows; proteinuria was negative both at before bed and in the early morning (a), positive urinary protein at before bed and negative in the early morning (b), urinary protein showed positive both at before bed and in the early morning (c): proteinuria was negative on arrival at health service center, after one hour rest, and after two hours rest, intermitent type (A), urinary protein changed from positive to negative by rest, positional type (B), and always positive urinary protein, persistent type (C). Nine groups was made by the combination of these types. Ditribution of groups was 27.9% (a-A group), 17.6% (b-B group), 14.7% (c-C group) and 0% (a-C group). Incidence of red blood cell in the urinary sediment in each group was under five red blood cell count in one high power field in negative group, and microhematuria was found in five of ten cases of persistent type and three of them showed over six blood cell count in one high power fieldIncidence of renal diseases in past hisotry decreased in the order of persistent type, positional type and intermitent type of proteinuria. High ASLO titer was found in over half cases of positional type and ASLO titer & proteinuria was decreased after administration of antibiotics (Sigmamicin). Possibility of infection influenced on the proteinuria of positional type was suspected. Results of PSP, Urea-N, Cholesterol, total protein and A/G ratio were in normal range and no signifficant difference among each group. Histological findings by renal biopsy from three cases of persistent type elucidated the presence of renal diseases. According to the results, examination of five urine specimen, past history, urinary sediment (red blood cell count) and ASLO was the important items of the examination of proteinuria discoverd by perioidical examination of college student. en-copyright= kn-copyright= en-aut-name=HirohataMamoru en-aut-sei=Hirohata en-aut-mei=Mamoru kn-aut-name=広畑衛 kn-aut-sei=広畑 kn-aut-mei=衛 aut-affil-num=1 ORCID= en-aut-name=WatanabeYutaka en-aut-sei=Watanabe en-aut-mei=Yutaka kn-aut-name=渡部寛 kn-aut-sei=渡部 kn-aut-mei=寛 aut-affil-num=2 ORCID= en-aut-name=MiyoshiKanji en-aut-sei=Miyoshi en-aut-mei=Kanji kn-aut-name=三好莞爾 kn-aut-sei=三好 kn-aut-mei=莞爾 aut-affil-num=3 ORCID= en-aut-name=NishiharaTakao en-aut-sei=Nishihara en-aut-mei=Takao kn-aut-name=西原孝雄 kn-aut-sei=西原 kn-aut-mei=孝雄 aut-affil-num=4 ORCID= en-aut-name=SeoKenji en-aut-sei=Seo en-aut-mei=Kenji kn-aut-name=瀬尾憲司 kn-aut-sei=瀬尾 kn-aut-mei=憲司 aut-affil-num=5 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=6 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=7 ORCID= en-aut-name=TakanoTosio en-aut-sei=Takano en-aut-mei=Tosio kn-aut-name=高野俊男 kn-aut-sei=高野 kn-aut-mei=俊男 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学保健管理センター affil-num=8 en-affil= kn-affil=岡山大学保健管理センター END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=9-10 article-no= start-page=867 end-page=875 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two Cases of Atypical Lymphocytos is Resembling "Prolymphocytic Leukemia" (Galton et al.) kn-title="Prolymphocytic leukemia" （Galtonら）に近似せると考えられる異型リンパ球の著増を来した2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Case 1: A 38-year-old housewife was admitted to our clinic on January 1973 because of fever and lymphocytosis of 4-months' duration. Leukocytosis (25,500/m㎥) with a marked lymphocytosis (70%) was present in peripheral blood. Twenty-four out of this 70% of lymphocytes were markedly atypical, showing indented or lobated nuclei and rather abundant basophilic cytoplasm. These cells were also seen in bone marrow in 2.6%. Phase contrast and electron microscopic observation revealed these cells to be rather mature atypical lymphocytes. Negative Paul-Bunnell test, low antibody titer for EB virus, and poor blstogenesis to stimulation by phytohemaggulutinin and T-cell nature of these lymphocytes were demonstrated. Prominent hepatosplenomegaly was characteristic though lymphoadenopathy was absent. Peripheral leukocyte counts increased progressively up to 20.4×10(4)/m㎥ while blasts were scarecely seen. In spite of administering Neocarzinostatin, vincristine and prednisolone. the patient died of pneumonia three months after admission. Necropsy using a Silverman needle revealed cytomegalic inclusion bodies in the lung and massive infiltration of, what appeared to be, atypical lymphocytes into the liver, spleen and kidney. Case 2: A 56-year-old male was admitted to the Okayama University Hospital at Misasa on March 1974, complaining of high temperature of 2-weeks' duration. Leukocyte counts in peripheral blood was 7,550/m㎥ with atypical lymphocytes, which were quite similar in shapes as well as in maturities to those seen in the Case 1 and were seen in 23.5%, whereas they were 7.8% in the bone marrow. Fever continued without responding to various antibiotics and prednisolone. Leukocyte counts were increased up to 23,600/m㎥ within two weeks and he died of massive interstitial pneumonia one month after the admission. Necropsy with a Silverman needle revealed cytomegalic inclusion bodies in the lung and infiltrations of atypical lymphocytes into the liver, spleen and kidney. Infectious mononucleosis can be ruled out on the basis of progressive and fatal clinical courses and other specific laboratory findings, although infection by Herpes type virus might play some role at the terminal stage of the disease. As the increase of atypical lymphocytes is so prominent in the peripheral blood and bone marrow, these 2 cases probably belong to lymphocytic leukemia; acute lymphocytic leukemia can easily be omitted because no blasts were seen. On the other hand, these cases cannot be categorized as conventional chronic lymphocytic leukemia in various points, showing atypical lymphocytes with variegated shapes and sizes, much shorter surviving time than that and poor response to therapy. Differentiation of these cases from "lymphosarcoma cell leukemia" is also made by their shorter clinical courses than that leukemia and absence of very characteristic nucleoli seen in that leukemia. Maturity of the cells from our cases also differ from those in lymphosarcoma cell leukemia; cells in our cases are maturer than those of that leukemia. "Prolymphocytic leukemia" reported by Galton et al. may be a disease entity to be most compatible with our cases. Marked lymphocytosis, short survival time, poor response to therapy, hepatosplenomegaly and absence of peripheral lymphoadenopathy accord well with the clinical features described by them. The characteristic cells, however, in the peripheral blood of prolymphocytic leukemia are somewhat different from those seen in our cases. The cells of that leukemia have a large vesicular nucleolus in almost every cases without appreciable clefts, indentations or lobations of nucleus, whereas less conspicuous nucleoli and more irregular nuclei in shape were frequently observed in our cases than in prolymphocytic leukemia. Incidentally, Akihama et al. reported a case quite resembling our cases, and proposed a new clinical entity which should be differentiated from chronic lymphocytic leukemia due to several reasons as stated before. Because of, however, the lack of proper autopsies and limited numbers of cases experienced so far, it will be too premature to state that these 3 cases, including that of Akihama et al., should be regarded as a new clinical entity. Further studies on the similar cases to ours will be needed to decide as to whether or not our 2 cases are indeed a variant of prolymphocytic leukemia. en-copyright= kn-copyright= en-aut-name=TaguchiHirokuni en-aut-sei=Taguchi en-aut-mei=Hirokuni kn-aut-name=田口博国 kn-aut-sei=田口 kn-aut-mei=博国 aut-affil-num=1 ORCID= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=2 ORCID= en-aut-name=TanakaToshio en-aut-sei=Tanaka en-aut-mei=Toshio kn-aut-name=田仲俊雄 kn-aut-sei=田仲 kn-aut-mei=俊雄 aut-affil-num=3 ORCID= en-aut-name=HayashiTakehiko en-aut-sei=Hayashi en-aut-mei=Takehiko kn-aut-name=林健彦 kn-aut-sei=林 kn-aut-mei=健彦 aut-affil-num=4 ORCID= en-aut-name=MiyoshiIsao en-aut-sei=Miyoshi en-aut-mei=Isao kn-aut-name=三好勇夫 kn-aut-sei=三好 kn-aut-mei=勇夫 aut-affil-num=5 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=2 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=3 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=4 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=6 en-affil= kn-affil=岡山大学医学部三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=電気化学的及び複合金属レドックスが駆動する電子移動反応によるβ-ラクタム系抗生物質の合成に関する研究 kn-title=Studies on synthesis of β-lactam antibiotics by use of electrochemical and multi redox-driven electron transfer reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TokumaruYoshihisa en-aut-sei=Tokumaru en-aut-mei=Yoshihisa kn-aut-name=徳丸祥久 kn-aut-sei=徳丸 kn-aut-mei=祥久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=3 article-no= start-page=199 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis and primary treatment of acute pancreatitis kn-title=急性膵炎の診断と初期治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaTsuneyoshi en-aut-sei=Ogawa en-aut-mei=Tsuneyoshi kn-aut-name=小川恒由 kn-aut-sei=小川 kn-aut-mei=恒由 aut-affil-num=1 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name=河本博文 kn-aut-sei=河本 kn-aut-mei=博文 aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=5-6 article-no= start-page=693 end-page=699 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the chemotherapy in acute leukemia Part I. Induction therapy with Neocarzinostatin alone kn-title=急性白血病の化学療法に関する研究 第1編 Neocarzinostatin単独による寛解導入療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neocarzinostatin (NCS) is an antitumor antibiotic isolated from streptomyces carzinostaticus by Ishida et al. in Japan in 1957. The chemical structure of NCS is a single chain made of acidic polypeptide consisting of 112 amino acids. Its antitumor activities have been demonstrated in various experimental tumors. Its mode of action is considered to inhibit DNA synthesis at early stage of S phase and to block it at G(2) phase. The agent has been used clinically for solid tumors without remardable effects, although never been used in treating human leukemia. For the first time the author has given NCS alone to patients with acute leukemia in the dose ranging from 0.04-0.06 mg/kg/day for 4-5 days as one course of treatment. In case no sufficient remission was induced further courses of treatment were repeated after an internal of 4-10 days, and obtained the following results. 1) Of 18 cases 7 (38.9%) attained complete remission and 4 (22.2%) partial remission. 2) Complete remission was obtained even in the patients with refractory varieties of acute leukemia, i.e., acute promyelocytic leukemia, monocytic leukemia and leukemia in aged group. 3) No noteworthy side effects other than occasional nausea or anorexia were observed and suppression on normal hematopoiesis was very slight. From these results it can be concluded that NCS is one of the most potent antileukemic agents for inducing remission in acute leukemia. en-copyright= kn-copyright= en-aut-name=KamimuraOkinobu en-aut-sei=Kamimura en-aut-mei=Okinobu kn-aut-name=上村致信 kn-aut-sei=上村 kn-aut-mei=致信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=3-4 article-no= start-page=387 end-page=392 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Candidiasis attributable to gastric ulcer kn-title=胃潰瘍に随伴せるCandida症に就いて en-subtitle= kn-subtitle= en-abstract=Candidiasis induced by antibiotics or steroid substances has often been reported. However, we found candidiasis in woman of 47 years which followed gastric ulcer without administration of such substances. This is extremely rare in Japan. kn-abstract=Candida症は真菌の一種のカンジダ属,特にCandida albicansによって起される疾病であり,本来は正常な皮膚,粘膜,糞便,喀痰,尿などに常在して人体に害を及ぼさない.近年各種の抗生物質,ステロイド製剤の開発に伴って,適応疾患に此等が容易に投与されており,此等薬剤の使用による副作用として色々な現象が現われて来ているが,そのうちの重要なる疾患の一つにCandida症が挙げられる.此のCandida症は上記薬剤の投与に依るのみならず,他疾患に基づく抵抗性の低下した患者においても認められることは周知の如くであり,例えば,白血病,再生不良性貧血,糖尿病等の患者,化学療法を受けた悪性腫瘍患者にも好発し易い.此等の場合多くは食道Candida症として見られることが多いが,今回我々の遭遇した患者は上記薬剤の投与もなく,心窩部痛を主訴として来院したものであり,食道,胃等の上部消化管X線検査によって,胃体中部小彎側に潰瘍像が認められ,潰瘍周辺部の粘膜像も不整を示しており一応悪性化が考えられた症例である.症例.患者は47才,主婦.主訴:約2週間前よりの心窩部痛.家族歴:特記すべきものなし.既往歴:生来健康であり薬剤常用等の経験はない.現病歴約2週間前より心窩部痛を来たし,その疼痛は心窩部をつまみ挙げる様であり特に空腹時に強く感じられ,時には夜中にも疼痛を来たすことがあった. 臨床検査 RBC,508×10(4),WBC,9200.分画像に異常なし.Hgb.16.0g/dl,MCV 98.0,GOT 26u,GPT 16u.尿一般検査では特に著変を認めない. 上部消化管X線検査 食道造影検査にては造影剤の通過は正常で狭窄等の異常所見なく,又粘膜レリーフ像にも著変は認められなかった.(Fig 1. A,B)胃造影検査では充満像では胃角部の短縮及び胃角上部小彎の不整が認められた.(Fig 2. C)圧迫撮影では小彎側中央部よりや,上方に潰瘍ニッシエがあり(Fig 2. D)潰瘍周辺は不整にして,通常みられる良性胃潰瘍よりもwallの巾が広く,又粘膜像においても潰瘍周辺部の顆粒状隆起,レリーフの不整が見られ,良性潰瘍像と少し異ったレ線像を呈しているので潰瘍癌の疑を持ち胃生検を行なうことにした. 胃内視鏡所見 胃体中部小彎側に大きな潰瘍による陥凹部を認め,その辺縁は平滑であったが,潰瘍部の周辺は隆起し潰瘍表面は不整で出血を認めた.そこで潰瘍部のうち3ヶ所をえらんで組織生検を行った. 生検組織所見 岡山大学医学部病理学教室に依頼した病理診断所見によれば,「Gastric ulcer with candidiasis and repairing mucosa, no malignancy｣ であり,間質にはround cell infiltrationがある. bleedingを伴っており,ulcer floorにはfungusが増殖している.再生上皮,異型性は余りない. (Fig.4, E.F.G.H) 以上の結果によりCandidaが増殖している場合には,組織学的に悪性度は認め難い場合でもcancerを完全に否定し得ないこともあり手術に踏切った. 摘出標本組織診断 「Gastric ulcer (Ul-Ⅳ) and chronic active gastritis, no malignancy.」ulcer floorはnecrotic massとgranulationが著明で此のgranulation changeはadipose tissueに及んでいる(Ul-Ⅳ).mucosaは比較的異型性は軽度でmalignancyの所見は認められず,間質はround cellのnodular infiltrationが著明に見られた.以上の如く生検並に手術摘出標本の組織所見によって胃レ線所見において悪性像の如く考えられたのは胃潰瘍に併存したCandidiasisの為によって,斯くの如きレ線像を呈したものと思われる.術后経過における種々の臨床検査成績に著変なく患者は順調である. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=2 ORCID= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=3 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木螢子 kn-aut-sei=赤木 kn-aut-mei=螢子 aut-affil-num=4 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=5 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=胃 cadida 症 kn-keyword=胃 cadida 症 en-keyword=X 線診断 kn-keyword=X 線診断 END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=9-10 article-no= start-page=783 end-page=790 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19821030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunochemotherapy with tumor antibody-Neocarzinostatin (NCS) conjugates. Part Ⅱ. Biological activities of antibody-NCS conjugates (NCS-immune IgG) kn-title=抗腫瘍抗体結合Neocarzinostatin(NCS)による免疫化学療法の研究 第2編 抗体結合Neocarzinostatin(NCS-immune IgG)の生物学的活性の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Anti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in the presence of water-soluble carbodiimide. The resulting mixture contained NCS-immune IgG. The conjugates inhibited the growth and (3)H-TdR incorporation of human leukemia cell line (NALL-1) cells. A membrane immunofluorescent test with FITC-labeled rabbit anti-NCS and goat anti-rabbit IgG antibodies showed specific localization of NCS-immune IgG on NALL-1 cell surfaces. These results indicate that NCS-immune IgG retains both NCS and antibody activities, and NCS-immune IgG should be useful for cancer therapy. en-copyright= kn-copyright= en-aut-name=KobayashiTakashi en-aut-sei=Kobayashi en-aut-mei=Takashi kn-aut-name=古林太加志 kn-aut-sei=古林 kn-aut-mei=太加志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=免疫化学療法 kn-keyword=免疫化学療法 en-keyword=抗腫瘍抗体結合抗癌剤 kn-keyword=抗腫瘍抗体結合抗癌剤 en-keyword=Neocarzinostatin kn-keyword=Neocarzinostatin END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=9-10 article-no= start-page=931 end-page=939 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19811030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunochemotherapy with tumor antibody-Neocarzinostatin(NCS) conjugates Part 1. Preparation of antibody-NCS conjugates kn-title=抗腫瘍抗体結合Neocarzinostatin(NCS)による免疫化学療法の研究 第1編 抗体結合Neocarzinostatin(NCS-immune IgG)の作製 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rabbit xenoantiserum was produced against a human null cell type leukemia cell line (NALL-1), and immune IgG was purified. NCS, a unique antitumor antibiotic that works on the tumor cell surface, was reacted with anti-NALL-1 rabbit IgG, in the presence of water soluble carbodiimide (WSCD). The resulting mixture was chromatographed on a Sephadex G-200 column. The first and second fractions were shown to contain NCS-immune IgG and no free NCS by the Ouchterlony double diffusion method and by immunoelectrophoresis. The conjugates inhibited the growth of Sarcina lutea and were more stable at conditions of 37℃ or 56℃ than free NCS. The conjugates did not loose inhibitory activities against the growth of S.lutea after frequent freezings and thawings. NCS-immune IgG might be useful in treating patients with cancer. en-copyright= kn-copyright= en-aut-name=KobayashiTakashi en-aut-sei=Kobayashi en-aut-mei=Takashi kn-aut-name=古林太加志 kn-aut-sei=古林 kn-aut-mei=太加志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=免疫化学療法 kn-keyword=免疫化学療法 en-keyword=抗腫瘍抗体 kn-keyword=抗腫瘍抗体 en-keyword=Neocarzinostatin kn-keyword=Neocarzinostatin END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=7-8 article-no= start-page=669 end-page=685 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on ethanol formation and its mechanism in corpses and stored biological samples kn-title=死体および保存臓器におけるアルコール産生とその機序に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of the present study was to investigate experimentally the formation of ethanol in corpses and stored biological samples important in medicolegal examination, and to study the mechanism of ethanol formation. In the tissues and bodily fluids of corpses, ethanol, n-propanol, iso-propanol, acetaldehyde, acetone and others may be formed to various degrees according to the postmortem conditions. The criteria of post-mortem ethanol formation are 20℃ and 24 hours of post-mortem time, and a significant amount of ethanol can be formed at higher temperatures and longer times. The presence of n-propanol in samples may be useful for ascertaining post-mortem ethanol formation. The amount of ethanol formed post-mortemly may be presumed to be under 20 times of the amount of n-propanol simultaneously detected. Post-mortem ethanol formation is not increased by ante-mortem ethanol intake. Ethanol may be produced in biological samples including cadaveric blood. Fresh aseptic blood is not conducive to ethanol formation within five days. The formation of n-propanol due to yeast in the stomach of corpses is lower than that due to bacteria in other organs and bodily fluids. The addition of antibiotics, which suppress the bacterial growth in the samples, and the addition of chemical inhibitors of ADH and ALDH contained in bacteria comletely blocked ethanol formation. It may be considered that ADH and ALDH in the bacteria in corpses produce ethanol from carbohydrates such as glucose and pyruvic acid through the reverse pathway of ethanol metabolism in living subjects. en-copyright= kn-copyright= en-aut-name=NagashimaHiroshi en-aut-sei=Nagashima en-aut-mei=Hiroshi kn-aut-name=長島洋 kn-aut-sei=長島 kn-aut-mei=洋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部法医学教室 en-keyword=post-mortem ethanol kn-keyword=post-mortem ethanol en-keyword=mechanism of ethanol formation kn-keyword=mechanism of ethanol formation en-keyword=ethanol and organ storage kn-keyword=ethanol and organ storage en-keyword=死体アルコール kn-keyword=死体アルコール END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=5-6 article-no= start-page=455 end-page=464 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=1988 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of stimulation by lincomycin of TEM β-lactamase production in E. coli. kn-title=リンコマイシンによるTEM型β-ラクタマーゼの産生増強メカニズム en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of lincomycin on the production of TEM β-lactamase by E. coli was studied to elucidate the mechanism of the stimulation by this antibiotic of the production of enterotoxins by certain bacteria. TEM β-lactamase was consistently measurable by a microiodometric assay. Lincomycin enhanced the activity of the enzyme encoded on the plasmid pBR322 2.4 times, while chromosomal β-galactosidase activity was inhibited. Lincomycin also stimulated the production of β-lactamase coded for by the bla gene integrated into the chromosome, but the antibiotic did not stimulate that of chloramphenicol acetyltransferase encoded on a ColEl-derived plasmid. The effect was independent of the copy number of the gene, suggesting that the effect takes place after transcription.The amount of bla mRNA was measured by [(3)H]-uridine pulse-labeling of mRNA followed by DNA-RNA hybridization. Lincomycin caused a 1.8 to 2.4-fold increase in the amount of bla mRNA. The possible presence of the repressor of the bla gene was examined by transducing the excess bla promoter region into E. coli 112-2, which carries Tn3 on its chromosome, but the repressor was not detected. The effect of bla promoters was examined by the construction of promoter deletion mutants of pBR322, each of which lacked one of two bla promoters. Lincomycin stimulated the production of β-lactamase coded by these plasmids at the same level as that coded by original pBR322, indicating that the effect was not due to increased transcription initiation. Preliminary examination of the degradation rate of bla transcripts showed that lincomycin increased half-life of bla mRNA. en-copyright= kn-copyright= en-aut-name=MatsushitaOsamu en-aut-sei=Matsushita en-aut-mei=Osamu kn-aut-name=松下治 kn-aut-sei=松下 kn-aut-mei=治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=lincomycin kn-keyword=lincomycin en-keyword=Escherichia coli kn-keyword=Escherichia coli en-keyword=TEM β-lactamase kn-keyword=TEM β-lactamase en-keyword=mRNA kn-keyword=mRNA en-keyword=DNA-RNA hybridization kn-keyword=DNA-RNA hybridization END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue= article-no= start-page=12 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical research for hospitalized patients with community-acquired pneumonia from 2002 to 2007 kn-title=2002－2007年における当院市中肺炎入院症例の臨床的研究 en-subtitle= kn-subtitle= en-abstract=The purpose of the study was to record clinically relevant medical outcomes in patients with community-acquired pneumonia and evaluate the performance of severity scores with the Guideline for community-acquired pneumonia edited by the Japanese Respiratory Society. During a 5-year period from April 2002 to March 2007, 142 patients with community-acquired pneumonia (40 females and 102 males) between 30 and 95 years of age who were admitted to our hospital were retrospectively included in this study. The mean age of the patients was 74.8 years. Twenty six patients were between 30 and 64 years of age, 30 patients were between 65 and 74 years of age, and 86 patients were between 75 and 95 years of age . The numbers of admission in each of the severity scores were：mild, 21； moderate, 99；severe, 17；and super severe, ５.The adherence to the Guideline for communityacquired pneumonia edited by the Japanese Respiratory Society for the initial antibiotics choice was high in mild, moderate and severe pneumonia (85.7％, 92.9％ and 94.1％) but was low in super severe pneumonia ( ０ ％) . The mean durations of hospitalization in each of the severity scores were：mild, 28.4 days；moderate, 39.9 days；severe, 48.5 days；and super severe, 45.2 days. Fourteen patients died. The numbers of death in each of the severity scores were： mild, ０；moderate, ７；severe, ４；and super severe, ３. The mean age of those who died was 81.8 years. Elderly, elevated blood urea nitrogen level, hypoxia, orientation disturbance, and hypotension were more frequent when the severity scores were elevated. Of the 142 patients with community-acquired pneumonia, 79 had chronic pulmonary disease and more respiratory system-related death. Our study indicated that the Guideline for community-acquired pneumonia edited by the Japanese Respiratory Society is a very useful tool for analyzing cases with community-acquired pneumonia in Japan. kn-abstract=当院に入院した市中肺炎症例の臨床像を明らかにし, 日本呼吸器学会2007年成人市中肺炎診療ガイドラインによる市中肺炎の重症度分類の妥当性を検討した｡2002年４月から2007年３月までの過去５年間に当院に入院した, 30歳から95歳までの市中肺炎109名142例 (男性72名102例, 女性37名40例) を対象に, その臨床像を検討した｡平均年齢は74.8歳で,65歳未満26例, 65歳以上75歳未満の前期高齢者30例, 75歳以上の後期高齢者86例であった｡ 肺炎重症度は軽症21例, 中等症99例, 重症17例, 超重症５例であった｡抗菌薬の選択に関して軽症では21例中18例, 中等症では99例中92例, 重症では17例中16例がガイドラインに準じていたが, 超重症では全例でガイドラインに準じていなかった｡平均入院日数は軽症28.4日,中等症39.9日, 重症48.5日, 超重症45.2日であった｡死亡例は, 軽症では無く, 中等症群７例, 重症群４例, 超重症群３例の計14例で, 死亡例の平均年齢は81.8歳であった｡重症度が悪化するにつれ, 高齢, BUN高値, 低酸素血症, 意識障害, 低血圧の頻度は増加傾向にあった｡79例で慢性呼吸器疾患を合併し, 慢性呼吸器疾患合併群では有意に呼吸器関連死亡が多かった｡日本呼吸器学会2007年成人市中肺炎診療ガイドラインは, 本邦の肺炎の重症度別症 例解析に適していると考えられた｡ en-copyright= kn-copyright= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=1 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=2 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=3 ORCID= en-aut-name=HamadaMasanori en-aut-sei=Hamada en-aut-mei=Masanori kn-aut-name=濱田全紀 kn-aut-sei=濱田 kn-aut-mei=全紀 aut-affil-num=4 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=5 ORCID= en-aut-name=KikuchiHiroshi en-aut-sei=Kikuchi en-aut-mei=Hiroshi kn-aut-name=菊池宏 kn-aut-sei=菊池 kn-aut-mei=宏 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター　内科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター　内科 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター　内科 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センターリハビリテーション科 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター　内科 affil-num=6 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター内科 affil-num=7 en-affil= kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター　内科 en-keyword=日本呼吸器学会2007年成人市中肺炎診療ガイドライン (the Guideline for communityacquired pneumonia edited by the Japanese Respiratory Society) kn-keyword=日本呼吸器学会2007年成人市中肺炎診療ガイドライン (the Guideline for communityacquired pneumonia edited by the Japanese Respiratory Society) en-keyword=市中肺炎 (community-acquired pneumonia) kn-keyword=市中肺炎 (community-acquired pneumonia) en-keyword=呼吸器関連死亡 (respiratory system-related death) kn-keyword=呼吸器関連死亡 (respiratory system-related death) en-keyword=高齢者 (elderly) kn-keyword=高齢者 (elderly) en-keyword=慢性呼吸器疾患 (chronic pulmonary disease) kn-keyword=慢性呼吸器疾患 (chronic pulmonary disease) END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue= article-no= start-page=88 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of anti - neutrophil cytoplasmic autoantibody-associated vasculitis: Resolution after early diagnosis kn-title=早期診断にて軽快したMPO-ANCA関連血管炎の一例 en-subtitle= kn-subtitle= en-abstract=A 76-year-old man was admitted to our hospital for pulmonary rehabilitation. Three years before admission he was diagnosed as pulmonary emphysema. On the day of admission the patient was febrile[37-38°C]. Initially lower respiratory infection was suspected and antibiotics was given to the patient, but his fever sustained. On admission he presented proteinuria and hematuria and the following examination revealed the high titer [307U/ml] of myeloperoxidase specific anti -neutrophil cytoplasmic autoantibody (MPO-ANCA). A gradual rise in serum creatinine levels after admission was also observed. He was diagnosed as MPO-ANCA associated vasculitis. Prednisolone therapy was started, which improved his symptoms and laboratory data rapidly. kn-abstract=症例は76歳男性03年前肺気腫と診断された｡今回呼吸器リハビリテーション目的で当院に入院の運びとなった｡入院時より37-38'Cの発熱を認め,下気道感染を疑い抗生剤で加療したが改善しなかった.入院時の検尿検査で蛋白･潜血陽性であり,血清MPO-ANCAが307U/mlと高値を示した｡血清クレアチニン値も徐々に上昇してきたため,MPO-ANCA関連血管炎と診断した.プレドニゾロン投与を開始したところ,症状及び検査所見は速やかに改善した. en-copyright= kn-copyright= en-aut-name=IchikawaHirohisa en-aut-sei=Ichikawa en-aut-mei=Hirohisa kn-aut-name=市川裕久 kn-aut-sei=市川 kn-aut-mei=裕久 aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=2 ORCID= en-aut-name=OnoKatsuichiro en-aut-sei=Ono en-aut-mei=Katsuichiro kn-aut-name=小野勝一郎 kn-aut-sei=小野 kn-aut-mei=勝一郎 aut-affil-num=3 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=4 ORCID= en-aut-name=YokoiTadashi en-aut-sei=Yokoi en-aut-mei=Tadashi kn-aut-name=横井正 kn-aut-sei=横井 kn-aut-mei=正 aut-affil-num=5 ORCID= en-aut-name=NagataTakuya en-aut-sei=Nagata en-aut-mei=Takuya kn-aut-name=永田拓也 kn-aut-sei=永田 kn-aut-mei=拓也 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TsugenoHirohumi en-aut-sei=Tsugeno en-aut-mei=Hirohumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=8 ORCID= en-aut-name=NishidaNorikazu en-aut-sei=Nishida en-aut-mei=Norikazu kn-aut-name=西田典数 kn-aut-sei=西田 kn-aut-mei=典数 aut-affil-num=9 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=10 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= en-aut-name=NoguchiYoshinori en-aut-sei=Noguchi en-aut-mei=Yoshinori kn-aut-name=野口菩範 kn-aut-sei=野口 kn-aut-mei=菩範 aut-affil-num=13 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝医療センター affil-num=13 en-affil= kn-affil=鳥取県中部医師会立三朝温泉病院内科 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯学総合研究科血液･腫癌･呼吸器内科学 en-keyword=ANCA関連血管炎 kn-keyword=ANCA関連血管炎 en-keyword=早期診断 kn-keyword=早期診断 en-keyword=顕微鏡的多発血管炎 kn-keyword=顕微鏡的多発血管炎 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1301 end-page=1310 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for small cell lung cancer Part 1. Reversal of adriamycin resistance in human small cell lung cancer cells in culture kn-title=肺小細胞癌の化学療法に関する研究　第1編　Adriamycin 耐性ヒト肺小細胞癌細胞株の耐性解除に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using adriamycin-resistant human small cell lung cancer cells (SBC-3/ADM), which were 30-fold more resistant to adriamycin than the parent cells (SBC-3), the ability of membrane-modifying agents to overcome the drug resistance was analyzed by a soft agar clonogenic assay. SBC-3/ADM was not circumvented by hyperthermia of 42℃ or amphotericin B at a concentration of 50μ M. Verapamil did not enhance the adriamycin cytoxicity in the SBC-3 cells at a concentration of 10μ M, but a 3.2-fold increase in the drug effect occurred in the SBC-3/ADM cells in terms of LD(70). The efflux of intracellular [H(3)] daunomycin from SBC-3/ADM cells was inhibited by verapamil, while the inhibition did not occur in the parent cells. Furthermore, quinidine (50μ M), cepharanthin (10μ M) and chloroquine (50μ M) enhanced the adriamycin cytotoxicity in the SBC-3/ADM cells. These findings suggest that some membrane-modifying agents could partially overcome the acquired resistance to adriamycin in human small cell lung cancer. en-copyright= kn-copyright= en-aut-name=YamashitaHidetoshi en-aut-sei=Yamashita en-aut-mei=Hidetoshi kn-aut-name=山下英敏 kn-aut-sei=山下 kn-aut-mei=英敏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=human small cell lung cancer cells in culture kn-keyword=human small cell lung cancer cells in culture en-keyword=ADM resistant subline kn-keyword=ADM resistant subline en-keyword=reversal of resistance kn-keyword=reversal of resistance END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=4-5 article-no= start-page=491 end-page=502 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cryptococcus症の研究 第IV編 Cryptococcus症の発症についての個体の抵抗と副腎皮質ホルモンとの関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the experimental infection of Cryptococcus neoformans M1 strain against the albino rats weighing 80 to 90 grams, morbidity, quantitative reduction culture from the various organs, histopathologic studies and 17-OHCS measurement in 24-hour urine were carried out. The retults were as follows: 1. The rats administered prednisolone only showed an increased C/F ratio (conjugated urinary 17-OHCS/ free urinary 17-OHCS) in proportion to the period of administraion in case the rats were given prednisolone at a dosis of 50μg. This suggested that prednisolone administered abunduntly becomes conjugated in the body rather than remains free. In contrast the rats given prednisolone at a dosis of 0.5μg showed the same C/F value with normal rats. 2. The unfavorable effects of adrenal corticoids on fungal infections were shown by changes of C/F, morbibity and the results obtained by reduction culture. These effects of adrenal corticoids were influenced neither by the quantity of administered prednisolone nor the time of administration. 3. The effectiveness of antifungal antibiotics on experimental cryptococcosis was determined by the day of initial death, morbidity, C/F ratio and the results obtained by reduction culture. The useful antifungal antibiotics were Amphotericin B, Trichomycin and Nystatin in a descending order of effectiveness. 4. In the experiment in which both. prednisolone and antifungal antibiotics were adminstered, the effects of antifungal antibiotics, even if they were strong enough, were diminished by the simultaneous administration of prednisolone. 5. Prednisolone was found to produce the cystic lesion in experimental cyptococcosis, while the addition of antifungal antibiotics reduced the lesion and induced the intense granulomatous changes. In this experiment, the useful antifungal antibiotics were Amphotericin B, Trichomycin and Nystatin in a descending order of effectiveness. en-copyright= kn-copyright= en-aut-name=YuharaAtsuyoshi en-aut-sei=Yuhara en-aut-mei=Atsuyoshi kn-aut-name=湯原淳良 kn-aut-sei=湯原 kn-aut-mei=淳良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1内科教室 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1007 end-page=1014 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on immunoprophylactic effects of OK-432 and Ge-132 on methylcholanthrene-induced mouse sarcoma Part 1. Suppressive effects of OK-432 and Ge-132 with respect to timing of administration, and the role of natural killer cells kn-title=BRM（OK-432 および Ge-132）によるメチルコラントレン誘発肉腫の発症抑制に関する研究 第1編 OK-432 および Ge-132 の投与時期による肉腫の発症に対する抑制効果および natural killer（NK)細胞の関与 en-subtitle= kn-subtitle= en-abstract= kn-abstract=C3H mice were subcutaneously (s.c.) injected with a tumorigenic dose (1mg/mouse) of 3-methylcholanthrene (MC) and tumor development was observed for 18 weeks. OK-432 or Ge-132 was intraperitoneally administered either after MC injection (post-treatment) or both before and after MC injection (pre- and post-treatment). Pre- and post-treatment with OK-432 significantly inhibited the development of tumors from 10 to 12 weeks after MC injection as compared with a control group. In all of the groups, the incidence of tumors was 100 percent 18 weeks after MC injection. With respect to Ge-132, both post-treatment and pre- and post-treatment administration reduced tumor growth in a similar manner to pre- and post-treatment of OK-432. After pre-treatment with OK-432 or Ge-132 for two weeks, the percentage of large granular lymphocytes in peripheral blood and the natural killer activity of splenic cells in mice were increased. These results suggest that the immune status plays an important role in the defense mechanisms against chemically-induced tumors. en-copyright= kn-copyright= en-aut-name=TamaiMamoru en-aut-sei=Tamai en-aut-mei=Mamoru kn-aut-name=玉井守 kn-aut-sei=玉井 kn-aut-mei=守 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Methylcholanthrene-induced sarcoma kn-keyword=Methylcholanthrene-induced sarcoma en-keyword=OK-432 kn-keyword=OK-432 en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=NK cell kn-keyword=NK cell END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=601 end-page=610 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of human bone marrow stromal cells in the aged Part 2. Effects of anticancer agents on the growing dynamics of bone marrow stromal cells in the aged and their ability to sustain normal hemopoiesis kn-title=骨髄間質細胞の老化に関する研究　第2編　高齢者骨髄間質細胞の増殖動態並びに造血支持能に及ぼす抗白血病剤の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Prolonged marrow suppresson after chemotherapy with anticancer agents is often seen, especially in elderly patients. The effects of anticancer agents on the growing dynamics of bone marrow stromal cells (BMSC) in the aged and their ability to sustain the growth of normal hemopoietic progenitor cells (suppportability) were examined to investigate the cause of prolonged marrow suppression. Daunorubicin (DNR) suppressed either the proliferation of BMSC or the ability to sustain hemopoiesis as a function of its concentration. Cytosine arabinoside (ara-C) did not suppress growing dynamics or supportability. Methotrexate (MTX) suppressed supportability at higher concentrations, even though it barely suppressed growing dynamics. These results were similar to those from an investigation in younger volunteers. It should be noted that DNR suppresses BMSC function at standard clinical concentrations. However, antimetabolites, especially ara-C are considered comparatively safe drugs for elderly patients. en-copyright= kn-copyright= en-aut-name=DeguchiSeigo en-aut-sei=Deguchi en-aut-mei=Seigo kn-aut-name=出口静吾 kn-aut-sei=出口 kn-aut-mei=静吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Human marrow stromal cells kn-keyword=Human marrow stromal cells en-keyword=Aging kn-keyword=Aging en-keyword=Chemotherapy kn-keyword=Chemotherapy en-keyword=Growing dynamics kn-keyword=Growing dynamics en-keyword=Ability to sustain hemopoiesis kn-keyword=Ability to sustain hemopoiesis END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=587 end-page=598 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acute leukemia in the aged : Chemotherapeutic effect of aclarubicin on acute nonlymphocytic leukemia kn-title=高齢者白血病の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate clinical management of acute nonlymphocytic leukemia (ANLL) in the aged, the chemotherapeutic effects of aclarubicin (ACR) were studied in 20 ANLL patients (M1 5, M2 3, M4 5, M5b 6, M6 1). All patients were over 70 years old. The ratio of male to female was 16 : 4 and age ranged from 70 to 84 years old (mediam : 76y/o). Nineteen patients were untreated, one case had previous treament and 2 patients showed hypoplastic marrow on admission. ACR was administered by intravenous drip infusion at a dose of 14mg/m2/day for 7-10 days and repeated after recovery of myelosuppression. Eight patients (40%) obtained complete remission (CR) : 1 of 5 M1 (20%), 3 of 5 M4 (60%), 4 of 6 M5b (66.7%) and none of M2 or M6. CR ratio was 44% in 18 typical ANLL patients excluding the two patients with hypoplastic marrow, who did not attain CR. The duration of CR was from 1.3 to 11.3 months (median : 7.3 months) and survial time ranged from 6.6 to 15.6 months (median : 11.8 months) in patients with CR. Although side effects on the digestive system such as nausea, vomiting and anorexia were seen in 11 of 20 patients, these effects were controllable. None of the patients showed cardiac toxicity. ACR is expected to be useful in the clinical management of ANLL in patients over 70 years old, especially for M4 and 5 in the aged. en-copyright= kn-copyright= en-aut-name=NakamuraTohru en-aut-sei=Nakamura en-aut-mei=Tohru kn-aut-name=中村達 kn-aut-sei=中村 kn-aut-mei=達 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=acute leukemia in the aged kn-keyword=acute leukemia in the aged en-keyword=antileukemic chemotherapy kn-keyword=antileukemic chemotherapy en-keyword=aclarubicin kn-keyword=aclarubicin END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=1019 end-page=1030 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for malignant lymphoma Part 2. Evaluation of anticancer drug combination on hematologic malignant cell lines using median effect analysis kn-title=悪性リンパ腫の化学療法に関する研究　第2編　血液腫瘍細胞に対する in vitro の薬剤併用効果：Median effect analysis による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To establish an effective combination chemotherapy for hematologic malignancies, the combined effects of four anthracycline-anthraquinones and five other drugs were assessed in vitro. The anthracycline-anthraquinones were adriamycin (ADM), aclarubicin (ACR), THP-adriamycin (THP-ADM), mitoxantrone (MXT) and five other drugs were 4-hydroperoxycyclophosphamide (4HO(2)-CTX), cytarabine (Ara-C), vincristine (VCR), etoposide (ETP), cisplatin (CDDP). Median effect analysis presented by Chou and Talalay was used to assess the combined effects of these drugs on two cell lines (HL-60 and Raji). In addition, the ratio of maximal tolerable dose (MTD) to the dose that produced 50% growth inhibition (Dm) was calculated to estimate the clinical activity of each drug. Data of MTD/Dm indicated that THP-ADM and MXT might be clinically superior to ADM and ACR. The results of median effect analysis shown by a combination index were as follows : As to HL-60 cells that were derived from acute promyelocytic leukemia cells, synergistic effects were seen in the combination of ACR and Ara-C, THP-ADM and CDDP, MXT and 4HO2-CTX, MXT and Ara-C, MXT and VCR, MXT and ETP, indicating that MXT showed efficient synergistic effects when combined with other drugs. As to Raji cells that were derived from Burkitt's lymphoma cells, synergistic effects were observed in the combinations of ADM and ETP, ADM and CDDP, ACR and VCR,THP-ADM and VCR, THP-ADM and ETP, THP-ADM and CDDP, MXT and VCR, indicating that THP-ADM showed efficient synergistic effects when combined with other drugs. en-copyright= kn-copyright= en-aut-name=UenoKunio en-aut-sei=Ueno en-aut-mei=Kunio kn-aut-name=上野邦夫 kn-aut-sei=上野 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=median effect analysis kn-keyword=median effect analysis en-keyword=in vitro 薬剤併用効果 kn-keyword=in vitro 薬剤併用効果 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=903 end-page=918 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Leukemic cell destruction kinetics in bone marrow kn-title=急性白血病寛解導入療法における骨髄内白血病細胞減少動態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An equation was developed to describe the kinetics of leukemic cell destruction in bone marrow during induction chemotherapy for acute nonlymphocytic leukemia (logZ＝K(1)t(4)＋K(2)t(3)＋K(3)t(2)＋K(4), where Z＝leukemic cell number, t＝time, and K＝a constant). The leukemic cell destruction curve was biphasic ; phase Ⅰ was the period from the initiation of a decrease in cells to the maximum velocity of the decrease, and phase Ⅱ was the subsequent period to the cessation of decrease. The following parameters were established : duration and acceleration of decrease in phases Ⅰ and Ⅱ, maximum velocity of decrease, duration of reduction, and residual volume of leukemic cells. 1. Patients who achieved CR showed a longer duration of phases Ⅰ and Ⅱ, a lower acceleration of the decrease in phase Ⅱ, and smaller residual leukemic cell volume than patients who did not achieve CR. there were no significant differences of parameters related to FAB classification, type of induction therapy, or the age of the patients. 2. This equation could be adapted to explain erythroblast kinetics during induction chemotherapy. There were no significant differences of the parameters with respect to the effect of induction therapy and patient age. 3. Patients with high acceleration of the decrease in phase Ⅱ had a short duration of CR and survival. The leukemic cell destruction curve was thought to be useful not only for evaluation of the effect of induction therapy, but also for establishment of post-remission chemotherapy. en-copyright= kn-copyright= en-aut-name=TakeuchiMakoto en-aut-sei=Takeuchi en-aut-mei=Makoto kn-aut-name=竹内誠 kn-aut-sei=竹内 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=acute leukemia kn-keyword=acute leukemia en-keyword=leukemic cell destruction curve kn-keyword=leukemic cell destruction curve en-keyword=leukemic cell destruction kinetics kn-keyword=leukemic cell destruction kinetics en-keyword=remission induction chemotherapy kn-keyword=remission induction chemotherapy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=81 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 2. Comparison of cytotoxic effect of anthracycline-anthraquinone analogues in tumor specimens obtained from lung cancer patients kn-title=Colony assay 法を用いた肺癌化学療法における Anthracycline-anthraquinone 系薬剤の有効性に関する研究 第2編 ヒト肺癌腫瘍材料における Anthracycline-anthraquinone 系薬剤の抗腫瘍効果の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The drug sensitivity test using a human tumor clonogenic assay is an in vitro technique providing a high degree of accuracy for predicting the clinical response to anticancer drugs. The author applied this assay to compare the in vitro anticancer efffects of four anthracycline-anthraquinone analogues against lung cancer. The drugs tested in the present study were adriamycin(ADM), aclarubicin(ACR), THP-adriamycin(THP-ADM) and mitoxantrone(MIT). A tumor was defined as sensitive, when the suviving fraction of colony-forming units was reduced 70% or more at a clinically achievable plasma concentration of these drugs in man. Tumor specimens from 100 individual patients were placed in culture. Forty-five specimens (45%) formed enough colonies to test durg sensitivity. Fourteen of the 31 specimens(45%) tested were found to be sensitive fof ACR, 15 of 35(43%) for THP-ADM, 10 of 30(33%) for MIT, and 7 of 43(16%) for ADM. These fingings indicated that the activity of ACR and THP-ADM is stronger than that of ADM in the treatment of lung cancer. en-copyright= kn-copyright= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name=沼田健之 kn-aut-sei=沼田 kn-aut-mei=健之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺癌腫瘍材料 kn-keyword=肺癌腫瘍材料 en-keyword=colony assay kn-keyword=colony assay en-keyword=anthracycline kn-keyword=anthracycline en-keyword=anthraquinone kn-keyword=anthraquinone END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=73 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 1. Comparison of antitumor activity of anthracycline-anthraquinone analogues in human lung cancer cell lines kn-title=Colony assay 法を用いた肺癌化学療法における Anthracycline-anthraquinone 系薬剤の有効性に関する研究 第1編 ヒト肺癌細胞株に対する Anthracycline-anthraquinone 系薬剤の殺細胞効果の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate the antitumor activity of new anthracycline-anthraquinone analogues ; aclarubicin (ACR), tetrahydropyranyl adriamycin (THP-ADM), and mitoxantrone(MIT), these analogues were compared with adriamycin(ADM) in terms of 70% lethal dose by colony assay using five human lung cancer cell lines, which had been established and maintained in our laboratory. The human lung cancer cell lines tested were EBC-1, an epidermoid cancer cell line, ABC-1, an adenocarcinoma cell line, and SBC-1, -2, and -3, small cell cancer cell lines. In general, the EBC-1 established from a patient tumor showing resistance to ADM was the least sensitive to the drugs tested, and SBC-3 established from a patient tumor with no prior chemotherapy was the most sensitive to the drugs. In antitumor activity, both ACR and THP-ADM appeared to be superior to ADM and MIT, suggesting the clinical usefulness of these drugs in the treatment of lung cancer. en-copyright= kn-copyright= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name=沼田健之 kn-aut-sei=沼田 kn-aut-mei=健之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺癌細胞株 kn-keyword=肺癌細胞株 en-keyword=colony assay kn-keyword=colony assay en-keyword=anthracycline kn-keyword=anthracycline en-keyword=anthraquinone kn-keyword=anthraquinone END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=733 end-page=739 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bacteriological study of chronic otitis media with repeated otorrhea kn-title=反復する慢性中耳炎耳漏の細菌学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Microorganisms were investigated in 44 patients with chronic otitis media (COM) and repeated otorrhea. The same species were isolated most frequently from those with repeated otorrhrea (24 of 44 cases). The species were Staph. aureus (10 caces), P.aeruginosa (9 cases), Staph. epidermidis (4 cases), and P.cepacia (1 case). For each species isolated from the same patient, similar sensitivity to antibiotics were observed. Therefore, we considered that reinfection by the bacteria existing in the body caused otorrhea in some cases. After NFLX was administered for MRSA infection in COM, Cephem antibiotics (CEZ, LMOX, etc) showed a recovery of sensitivity to Staph. aureus. We observed a superinfection by Methicillin-Cephem-Resistant Staph. epidermidis (MRSE) after antibiotics therapy for MRSA in COM. en-copyright= kn-copyright= en-aut-name=KosakaMasakazu en-aut-sei=Kosaka en-aut-mei=Masakazu kn-aut-name=小坂正和 kn-aut-sei=小坂 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 en-keyword=bacteriological study kn-keyword=bacteriological study en-keyword=chronic otitis media kn-keyword=chronic otitis media en-keyword=sensitivity to antibiotics kn-keyword=sensitivity to antibiotics en-keyword=otorrhea kn-keyword=otorrhea END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=7-8 article-no= start-page=203 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Potential role of granulocyte colony stimulating factor in treating urinary tract infection kn-title=尿路感染症治療における Granulocyte Colony-Stimulating Factor (G-CSF) の有用性に関する基礎的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The priming effects of granulocyte colony stimulating factor (G-CSF) on neutrophil function and anti-pseudomonal activity were examined under various osmotic conditions created with urea and NaCL (280mOsm., 400mOsm., 800mOsm.) in vitro. Consequently, the prophylactic effect of G-CSF on post-operative urinary tract infection after transurethral resection of the prostate were examined experimentally. As a result, neutropil chemiluminescence was significantly enhanced by G-CSF under physiological osmotic conditions. However, enhancement was not observed under hyperosmotic conditions as in the urine. Similarly, the anti-pseudomonal activity of human neutrophils was not enhanced by G-CSF under hyperosmotic condition. However, whole blood chemiluminescence in patients after transurethral resection of the prostate was significantly enhanced by the administration of G-CSF. Moreover, postoperative urinary tract infection, considered an infection of the submucosal layer, was not obsereved, suggesting that the neutrophil priming effect occurred in the submucosal layer not in the urinary tract. en-copyright= kn-copyright= en-aut-name=HataKazuhiro en-aut-sei=Hata en-aut-mei=Kazuhiro kn-aut-name=畠和宏 kn-aut-sei=畠 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科学教室 en-keyword=urinary tract infection kn-keyword=urinary tract infection en-keyword=G-CSF kn-keyword=G-CSF en-keyword=chemiluminescence kn-keyword=chemiluminescence en-keyword=neutrophil function kn-keyword=neutrophil function END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=117 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Erythromycin therapy in patients with diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究―エリスロマイシン少量長期投与を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Low dose and long-term erythromycin (EM) therapy showed obvious improvement of symptoms and prognosis in patients with DPB. However, mechanisms involved in these clinical effects of EM therapy remain controversial. In this study, the clinical effects of EM therapy on respiratory function, bacterial flora in the lower airway and serum levels of soluble IL-2 receptor (sIL-2R) as an indicator of T-cell activation were examined. All parameters of respiratory functions in patients with DPB including % VC, % FEV 1.0, % V50, % V25 and V50/V25 showed marked improvements within 6 months of EM therapy. Continuous administration of EM for 6 to 24 months produced minimal changes in these respiratory functions though decreases in some parameters were observed in patients with advanced clinical stage and in eldely patients. The increase of % FEV 1.0 exceeded those of % V50 and % V25 after EM therapy. This indicates severe pathological changes in small airways or variable effects of EM therapy. Bacterial species and sensitivities to antibiotics showed no apparent changes after long-term EM therapy. The serum levels of sIL-2R in patients with DPB were higher than those in normal controls. With EM therapy, serum levels of sIL-2R decreased rapidly within 6 months, but these levels remained higher than those in normal controls, even after long-term EM therapy. en-copyright= kn-copyright= en-aut-name=FukudaTomoko en-aut-sei=Fukuda en-aut-mei=Tomoko kn-aut-name=福田智子 kn-aut-sei=福田 kn-aut-mei=智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=diffuse panbronchiolitis kn-keyword=diffuse panbronchiolitis en-keyword=erythromycin kn-keyword=erythromycin en-keyword=呼吸機能 kn-keyword=呼吸機能 en-keyword=soluble IL-2 reseptor kn-keyword=soluble IL-2 reseptor en-keyword=喀痰中細菌叢 kn-keyword=喀痰中細菌叢 END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=75 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duration of fecal shedding in enterohemorrhagic Escherichia coli O157 kn-title=腸管出血性大腸菌O157感染者における菌陰性化に要する期間についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In June 1997, an outbreak of enterohemorrhagic Escherichia coli O157 occurred at a hospital of Okayama City, Japan. E. coli O157 was isolated from 86 patients (40 males and 46 females). Ages ranged from 14 to 96 years old with a mean of 53 years old. All the infected patients (59 asymptomatic carriers) were investigated in this study. The median duration of shedding (from starting therapy), among the 83 patients who received antimicrobial therapy, was 6 days. This result has paticular importance for taking appropriate measures during outbreaks among adults who have other diseases. Other factors (age,sex,etc) that might have affected the duration of shedding were aiso investigated, but were not found to be influential. Among the infected patients, elderly people, females and patients who had other diseases became symptomatic, and in paticular, patients who had severe malignancy became symptomatic. All asymptomatic carriers received antimicrobial therapy and no newly affected cases and no side effects among those patients were observed. these results indicate that antimicrobial therapy for asymptomatic carriers in facilities that have a large number of susceptible people is useful. en-copyright= kn-copyright= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name=高尾総司 kn-aut-sei=高尾 kn-aut-mei=総司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学講座 en-keyword=E. coli O 157 kn-keyword=E. coli O 157 en-keyword=asymptomaic carrier kn-keyword=asymptomaic carrier en-keyword=fecal shedding time kn-keyword=fecal shedding time en-keyword=antibiotics kn-keyword=antibiotics END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=9-12 article-no= start-page=205 end-page=209 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical pathway in breast conservation operation in Okayama Central Hospital kn-title=クリニカルパスウエイを用いた乳癌術後管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We performed a breast conservation operation in 5 patients using a clinical pathway in 1995 and analyzed the effect on the patient's outcome. Compared to 5 patients without a clinical parthway during the same time peried, the mean hospital stay decreased from 10.8 to 4.6 days and the amount of antibiotics decreased from 9.0 to 2.0g. A satisfactory effect was pbserved on the establishment of communication between staff and the standardized care of patiens. Breast conservation operation seems to be a good candidate for the introduction of a clinical pathway. Further improvement could be obtained by reviewing the outcome of patients. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=2 ORCID= en-aut-name=OkaItsuho en-aut-sei=Oka en-aut-mei=Itsuho kn-aut-name=岡伊津穂 kn-aut-sei=岡 kn-aut-mei=伊津穂 aut-affil-num=3 ORCID= en-aut-name=KenmotsuMasakazu en-aut-sei=Kenmotsu en-aut-mei=Masakazu kn-aut-name=剣持雅一 kn-aut-sei=剣持 kn-aut-mei=雅一 aut-affil-num=4 ORCID= en-aut-name=KataikaMasafumi en-aut-sei=Kataika en-aut-mei=Masafumi kn-aut-name=片岡正文 kn-aut-sei=片岡 kn-aut-mei=正文 aut-affil-num=5 ORCID= en-aut-name=UmeokaTatsuo en-aut-sei=Umeoka en-aut-mei=Tatsuo kn-aut-name=梅岡達生 kn-aut-sei=梅岡 kn-aut-mei=達生 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院 affil-num=2 en-affil= kn-affil=岡山中央病院 affil-num=3 en-affil= kn-affil=岡山中央病院 affil-num=4 en-affil= kn-affil=岡山中央病院 affil-num=5 en-affil= kn-affil=岡山大学第一外科 affil-num=6 en-affil= kn-affil=岡山大学第一外科 en-keyword=クリニカルパス kn-keyword=クリニカルパス en-keyword=平均在院日数 kn-keyword=平均在院日数 en-keyword=医療費削減 kn-keyword=医療費削減 en-keyword=患者満足度 kn-keyword=患者満足度 END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=1 article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010428 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular epidemiology of Enterococcus faecalis isolated from patients with urinary tract infection kn-title=尿路感染症由来 Enterococcus faecalis の病原性因子に関する分子疫学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Enterococcus faecalis is a frequent cause of hospital-acquired infection. Two hundred fifty one E. faecalis isolates from patients with urinary tract infection at Okayama University Hospital over an 8-year period from 1991 through 1998 were collected. The presence of the asaⅠ, cylA, aac (6')-aph (2''), and aph (3')-Ⅲgenes was analyzed by PCR methods. Of the 251 isolates, 205(81.7%) were positive for asaⅠ. The 81.5% (167/205) of asaⅠ-positive isolates also possessed either cylA or aminoglycoside resistance genes, compared to only 15.2% of (7/46) asaI-negative isolates (p<0.0001). The incidence of asaI gradually increased from 69.2% in 1991 to 90.7% in 1998. The number of isolates that contain asaI, cylA and asaI-positive and hemolysin-producing isolates revealed 22 different banding patterns, including 6 pairs with similar patterns. The plasmid analyses of these isolates showed different patterns except for 1 pair with similar PFGE pattern. These results suggest that E. faecalis possessing the asaⅠ gene may play an important role in the exchange of genetic information among enterococci in the urinary tract. en-copyright= kn-copyright= en-aut-name=IshiiAyano en-aut-sei=Ishii en-aut-mei=Ayano kn-aut-name=石井亜矢乃 kn-aut-sei=石井 kn-aut-mei=亜矢乃 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科学講座 en-keyword=尿路感染症 kn-keyword=尿路感染症 en-keyword=Enterococcus faecalis kn-keyword=Enterococcus faecalis en-keyword=asaⅠ kn-keyword=asaⅠ en-keyword=cylA kn-keyword=cylA END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=199 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒストンアセチル化制御による実験的関節炎の抑制 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西田圭一郎 kn-aut-sei=西田 kn-aut-mei=圭一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 人体構成学 en-keyword=関節リウマチ kn-keyword=関節リウマチ en-keyword=エピジェネティクス kn-keyword=エピジェネティクス en-keyword=ヒストン脱アセチル化酵素阻害剤 kn-keyword=ヒストン脱アセチル化酵素阻害剤 en-keyword=CDKインヒビター kn-keyword=CDKインヒビター en-keyword=抗II型コラーゲン抗体誘導関節炎 kn-keyword=抗II型コラーゲン抗体誘導関節炎 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1 article-no= start-page=105 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Metabolism of Acinomycetes and Assay Method with Microoganism kn-title=放線菌の代謝および微生物による効力測定に関する研究 en-subtitle= kn-subtitle= en-abstract=私は研究生活の大部分を企業にて過ごしたので省みての成果もほとんどが企業での研究であった。そこで幸いにも私が商品化に拘わったものがEnramysin-飼料添加物、Validamycin-イネ紋枯病殺菌剤、Sedecamycin－豚赤痢治療剤の3種は現在でも広く用いられ人々の役にたっている。また、不幸にも商品化出来なかったが、研究としては何らかの成果を残し得たものとしてRufomycin,Maridomycin,Anasamitocin及び殺菌剤の測定法及びその関連の研究を残すことが出来たのでそれらの成果をまとめた。 kn-abstract=The　microorganisms belonging to actinomycetes been important as the antibiotic producers and my major job has been a screening for useful new antibiotics produced by a actinomycete almost in my reseach.My collaborators and I found nineteen new antibiotics between 1956 and 1980 and thereafter three antibiotics particululy (Enramycin-feed additive,Validamycin-agriculture use,effective against the seach blight disease of rice plants,Ssdecamycin-effective agaist swine dysenteriae)were developed for industrial production and become useful for many people.And also we were interrested in those chemical structres and activities,fermentation processes by mutants or producing organsums namely rufomycins,maridomycins and ansamitocins.And from another point a new assay method for the activities of disinfectants was epoch making invesitgation. en-copyright= kn-copyright= en-aut-name=HigashideEiji en-aut-sei=Higashide en-aut-mei=Eiji kn-aut-name=東出栄治 kn-aut-sei=東出 kn-aut-mei=栄治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=actinomycetes kn-keyword=actinomycetes en-keyword=screening on antibiotics kn-keyword=screening on antibiotics en-keyword=enramycin kn-keyword=enramycin en-keyword=validamycin kn-keyword=validamycin en-keyword=sedecamycin kn-keyword=sedecamycin en-keyword=new assay method of disinfectants kn-keyword=new assay method of disinfectants END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1 article-no= start-page=13 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Isolation and Purification of Nocardamine from the Validamycin Producer kn-title=バリダマイシン生成菌培養液から抗細菌性抗生物質ノカルダミンの分離・精製 en-subtitle= kn-subtitle= en-abstract=Streptomyces hygroscopicus subsp. limoneus はバリダマイシン生成菌として知られているが、その抗カビ物質以外に抗細菌性抗生物質を生成することは知られていない。われわれはその微生物がバリダマイシン非生成条件において生成する抗細菌性抗生物質を見出そうと試みた。その結果、グラム陰性細菌に活性を示す抗生物質EO-3を得たのでこれを分離・精製してノカルダミンと同定した。本報告では本抗生物質の培養条件、抗菌スペクトル、精製および同定方法について述べる。尚、この研究は平成6年度から8年度までの3年間に亙る岡山大学学内特定研究『特殊環境生物の機能開発と物質生産への応用』を分担して行ったものである。 kn-abstract=An antibacterial active against P. mirabilis was isolated from the culture of Streptomyces hygroscopicus subsp. limoneus, validamycin producer. The antibiotic was found to be produced with a non-validamycin producing condition. The antibiotic was identified as nocardamine with the analytical data, IR, 1H-NMR and 13C-NMR spectra. en-copyright= kn-copyright= en-aut-name=HigashideEiji en-aut-sei=Higashide en-aut-mei=Eiji kn-aut-name=東出栄治 kn-aut-sei=東出 kn-aut-mei=栄治 aut-affil-num=1 ORCID= en-aut-name=OmatsuYoshiharu en-aut-sei=Omatsu en-aut-mei=Yoshiharu kn-aut-name=大松義治 kn-aut-sei=大松 kn-aut-mei=義治 aut-affil-num=2 ORCID= en-aut-name=InoueSuemi en-aut-sei=Inoue en-aut-mei=Suemi kn-aut-name=井上末瑞 kn-aut-sei=井上 kn-aut-mei=末瑞 aut-affil-num=3 ORCID= en-aut-name=KimuraYoshinobu en-aut-sei=Kimura en-aut-mei=Yoshinobu kn-aut-name=木村吉伸 kn-aut-sei=木村 kn-aut-mei=吉伸 aut-affil-num=4 ORCID= en-aut-name=KanzakiHiroshi en-aut-sei=Kanzaki en-aut-mei=Hiroshi kn-aut-name=神崎浩 kn-aut-sei=神崎 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name=中島修平 kn-aut-sei=中島 kn-aut-mei=修平 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 en-keyword=Streptomyces kn-keyword=Streptomyces en-keyword=antibacterial compoud kn-keyword=antibacterial compoud en-keyword=nocardamine kn-keyword=nocardamine en-keyword=non-validamycin producing condition kn-keyword=non-validamycin producing condition END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=多重金属酸化･還元系における炭素ー炭素結合形成反応とそのβ-ラクタム系抗生物質合成への応用 kn-title=Studies on Carbon-Carbon Bond Making Reaction in a Multi-Metal Redox System and Its Application to β-Lactam Antibiotics Synthesis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=趙金峰 kn-aut-sei=趙 kn-aut-mei=金峰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=セファロスポリン系抗生物質合成における特異的官能基変換に関する研究 kn-title=Studies on Expedient Functionalization in Cephalosporin Antibiotic Synthesis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷口正俊 kn-aut-sei=谷口 kn-aut-mei=正俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=複合金属反応系を用いるβ-ラクタム系抗生物質の合成に関する研究 kn-title=Studies on Synthesis of β-Lactam Antibiotics by Use of Multimetal Systems en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=角田真一 kn-aut-sei=角田 kn-aut-mei=真一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗生物質によるブドウの無核果誘導とそのメカニズム kn-title=Seedlessness Induction by Antibiotics and Its Mechanism in Grapes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=WinarsoDrajad Widodo kn-aut-sei=Winarso kn-aut-mei=Drajad Widodo aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒトRC-K8リンパ腫細胞とヒトH69肺小細胞癌におけるアントラサイクリンによるウロキナーゼの発現誘導 kn-title=Induction of Urokinase-field name="type" Plasminogen Activator by the Anthracycline Antibiotic in Human RC-K8 Lymphoma and H69 Lung Carcinoma Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木口亨 kn-aut-sei=木口 kn-aut-mei=亨 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=飲酒時のアセトアルデヒドの代謝に及ぼす抗悪性腫瘍薬,抗生物質および糖尿病治療薬の影響 kn-title=EFFECTS OF ANTINEOPLASTICS, ANTIBIOTICS AND ANTIDIABETICS ON ACETALDEHYDE METABOLISM AFTER ALCOHOL INGESTION en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=菅晋 kn-aut-sei=菅 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1 article-no= start-page=73 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=1970 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Silage-Making : XII. The Effects of Adding Antibiotics or Kylage at the Ensiling Time kn-title=サイレージの調整法に関する研究 (第12報)抗生物質およびギ酸カルシウム混合剤添加の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=サイレージを安定に調製するための添加剤として抗生物質およびギ酸カルシウム混合剤（Kylage）の効果を知るため,イタリアンライグラスを材料に用い,これにBacitracin 5 ppn 力価,Neomycin 5 ppm 力価,Kylage 0.28％をそれぞれ添加してサイレージを調整し,無添加対照,添加対照としてGluose添加のサイレージと,その品質および飼料価値を比較した. すなわち,でき上りサイレージについて,化学成分・品質・飼料価値などを調査して,その効果を検討した. 得たる結果の要約はつぎのようである. 1)でき上りサイレージ廃棄量はNeomycin区が0であるほかは,どの区も相当量生じたが,対照区に比べB包acitracin, Kylage区は少なかった. 2)サイレージの品質鑑定の結果は,Kylage区83点,Bacitracin区66点,対照区47点,Glucose添加区94点に対し,Neomycin区は38点になり,Neomycinはサイレージ添加剤として,有効なものでないことが認められた. 3)Bacitracin, Neomycinの添加によって,サイレージの消化率改善は認められなかった. 4)Kylageの添加によって,品質の改善が認められたが,消化率の改善は認められなかった. 5)ウシ・ヤギ・ヒツジ・ウサギをもって簡易し好試験を行なったが,Glucose添加サイレージがもっともよくし食された外は,各区間に大きな差は認められなかった. 6)Glucose添加(2%)を標準(100)とする添加効率は,Bacitrain40,Neomycin-19,Kylage77%で,添加物3者の比較ではKylageがもっとも高かった。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=須藤浩 kn-aut-sei=須藤 kn-aut-mei=浩 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=内田仙二 kn-aut-sei=内田 kn-aut-mei=仙二 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅一憲 kn-aut-sei=三宅 kn-aut-mei=一憲 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END