Conditions

close

result 4837 件

FullText URL fulltext.pdf
Author Haratake, Tomoka| Nishimura, Midori Filiz| Nishikori, Asami| Gonzalez, Michael V.| Ennishi, Daisuke| Lai, You Cheng| Ochi, Sayaka| Tsunoda, Manaka| Fajgenbaum, David C.| van Rhee, Frits| Momose, Shuji| Sato, Yasuharu|
Keywords idiopathic multicentric Castleman disease integrin subunit alpha 5 PI3K–Akt signaling pathway platelet-derived growth factor receptor beta vascular endothelial growth factor A vascularity
Published Date 2025-08
Publication Title Modern Pathology
Volume volume38
Issue issue8
Publisher Elsevier BV
Start Page 100782
ISSN 0893-3952
NCID AA1067307X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 THE AUTHORS.
File Version publisher
PubMed ID 40274066
DOI 10.1016/j.modpat.2025.100782
Web of Science KeyUT 001491556800003
Related Url isVersionOf https://doi.org/10.1016/j.modpat.2025.100782
FullText URL fulltext.pdf
Author Kato, Koji| Kumazawa, Minoru| Nakajima, Yoshiki| Suzuki, Takehiro| Dohmae, Naoshi| Shen, Jian-Ren| Ifuku, Kentaro| Nagao, Ryo|
Published Date 2025-05-16
Publication Title Science Advances
Volume volume11
Issue issue20
Publisher American Association for the Advancement of Science
Start Page eadv7488
ISSN 2375-2548
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
File Version publisher
PubMed ID 40378202
DOI 10.1126/sciadv.adv7488
Web of Science KeyUT 001489655000004
Related Url isVersionOf https://doi.org/10.1126/sciadv.adv7488
FullText URL fulltext.pdf
Author Takei, Kensuke| Inokuchi, Toshihiro| Hiraoka, Sakiko| Ishiguro, Mikako| Toyosawa, Junki| Aoyama, Yuki| Igawa, Shoko| Takeuchi, Keiko| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Kawano, Seiji| Mitsuhashi, Toshiharu| Otsuka, Motoyuki|
Keywords CD, Crohn's disease LRG, Leucine-rich alpha-2 glycoprotein Fcal, Fecal calprotectin CRP, C-reactive protein ER, Endoscopic remission
Published Date 2025-05-13
Publication Title BMC Gastroenterology
Volume volume25
Issue issue1
Publisher BMC
Start Page 364
ISSN 1471-230X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40355822
DOI 10.1186/s12876-025-03880-5
Web of Science KeyUT 001488265300002
Related Url isVersionOf https://doi.org/10.1186/s12876-025-03880-5
FullText URL fulltext.pdf
Author La Rocca, Romain| Kato, Koji| Tsai, Pi-Cheng| Nakajima, Yoshiki| Akita, Fusamichi| Shen, Jian-Ren|
Published Date 2025-05-05
Publication Title Nature Communications
Volume volume16
Issue issue1
Publisher Nature Portfolio
Start Page 4175
ISSN 2041-1723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40325014
DOI 10.1038/s41467-025-59512-9
Web of Science KeyUT 001482932500018
Related Url isVersionOf https://doi.org/10.1038/s41467-025-59512-9
JaLCDOI 10.18926/AMO/68729
FullText URL 79_3_209.pdf
Author Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi|
Abstract A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered.
Keywords methemoglobinemia aniline methylene blue cyanosis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 209
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/68726
FullText URL 79_3_185.pdf
Author Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya|
Abstract We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners.
Keywords breast cancer patient young patient single partners relationships
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 185
End Page 195
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/68723
FullText URL 79_3_157.pdf
Author Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori|
Abstract Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.
Keywords advanced glycation end product aging cartilage collagen aggrecan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 157
End Page 166
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
Author Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito|
Keywords adverse event breast cancer pertuzumab trastuzumab VigiBase
Note This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025; 1-13. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.|
Published Date 2025-05-08
Publication Title British Journal of Clinical Pharmacology
Publisher Wiley
ISSN 0306-5251
NCID AA00574388
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 British Pharmacological Society.
File Version author
PubMed ID 40344285
DOI 10.1002/bcp.70094
Web of Science KeyUT 001483932800001
Related Url isVersionOf https://doi.org/10.1002/bcp.70094
FullText URL fulltext.pdf
Author Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara|
Keywords animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin
Published Date 2025-05-01
Publication Title Infection and Immunity
Publisher American Society for Microbiology
ISSN 0019-9567
NCID AA00673732
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Kuriu et al.
File Version publisher
PubMed ID 40310291
DOI 10.1128/iai.00126-25
Web of Science KeyUT 001479415700001
Related Url isVersionOf https://doi.org/10.1128/iai.00126-25
Author Kawajiri, Takahiro| Hosoya, Masahiro| Goda, Satoshi| Sato, Eisuke| Suga, Seiji|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.5c01138.| This fulltext file will be available in Apr. 2026.|
Published Date 2025-04-29
Publication Title Organic Letters
Volume volume27
Issue issue18
Publisher American Chemical Society (ACS)
Start Page 4737
End Page 4741
ISSN 1523-7060
NCID AA11347843
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 American Chemical Society
File Version author
PubMed ID 40302371
DOI 10.1021/acs.orglett.5c01138
Web of Science KeyUT 001479279200001
Related Url isVersionOf https://doi.org/10.1021/acs.orglett.5c01138
FullText URL fulltext.pdf
Author Kuang, Canyan| Hirai, Anna| Kamei‑Νagata, Chiaki| Nango, Hiroshi| Ohtani, Masahiro| Omori, Kazuhiro| Takashiba, Shogo|
Keywords AGE experimental periodontitis bone resorption inflammation osteoclasts
Published Date 2025-04-11
Publication Title Biomedical Reports
Volume volume22
Issue issue6
Publisher Spandidos Publications
Start Page 97
ISSN 2049-9434
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2025 Kuang et al.
File Version publisher
PubMed ID 40297801
DOI 10.3892/br.2025.1975
Web of Science KeyUT 001477956200001
Related Url isVersionOf https://doi.org/10.3892/br.2025.1975
FullText URL fulltext.pdf
Author Sam, Truong Thao| Somura, Hiroaki| Moroizumi, Toshitsugu|
Keywords hydrological model drought coffee irrigation water-saving technique water allocation
Published Date 2025
Publication Title Hydrological Research Letters
Volume volume19
Issue issue2
Publisher Japan Society of Hydrology and Water Resources
Start Page 94
End Page 100
ISSN 1882-3416
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
DOI 10.3178/hrl.24-00029
Web of Science KeyUT 001471091300001
Related Url isVersionOf https://doi.org/10.3178/hrl.24-00029
FullText URL fulltext.pdf
Author Maruo, Yukinori| Kuwahara, Miho| Yoshihara, Kumiko| Irie, Masao| Nagaoka, Noriyuki| Yoshizane, Mai| Matsumoto, Takuya| Akiyama, Kentaro|
Keywords silane coupling bond strength ceramic feldspathic lithium polymer-infiltrated ceramic CAD/CAM
Published Date 2025-04-27
Publication Title Materials
Volume volume18
Issue issue9
Publisher MDPI
Start Page 1983
ISSN 1996-1944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 40363487
DOI 10.3390/ma18091983
Web of Science KeyUT 001486402200001
Related Url isVersionOf https://doi.org/10.3390/ma18091983
FullText URL fulltext.pdf
Author Dong, Yubing| Wang, Guohao| Ujihara, Yoshihiro| Chen, Yanzhu| Yoshida, Masashi| Nakamura, Kazufumi| Katanosaka, Kimiaki| Naruse, Keiji| Katanosaka, Yuki|
Published Date 2025-05-08
Publication Title Communications Biology
Volume volume8
Issue issue1
Publisher Nature Portfolio
Start Page 715
ISSN 2399-3642
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40341813
DOI 10.1038/s42003-025-08167-9
Web of Science KeyUT 001485486400005
Related Url isVersionOf https://doi.org/10.1038/s42003-025-08167-9
FullText URL fulltext.pdf
Author Takatori, S.| Pimon, M.| Pollitt, S.| Bartokos, M.| Beeks, K.| Grueneis, A.| Hiraki, T.| Honma, T.| Hosseini, N.| Leitner, A.| Masuda, T.| Morawetz, I| Nitta, K.| Okai, K.| Riebner, T.| Schaden, F.| Schumm, T.| Sekizawa, O.| Sikorsky, T.| Takahashi, Y.| De Col, Col, L. Toscani| Yamamoto, R.| Yomogida, T.| Yoshimi, A.| Yoshimura, K.|
Keywords solid-state nuclear clock thorium-229 XAFS
Published Date 2025-04-28
Publication Title New Journal of Physics
Volume volume27
Issue issue4
Publisher IOP Publishing
Start Page 043024
ISSN 1367-2630
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
DOI 10.1088/1367-2630/adce22
Web of Science KeyUT 001477975100001
Related Url isVersionOf https://doi.org/10.1088/1367-2630/adce22
FullText URL fulltext.pdf
Author Matsuura, Hiroaki| Ishino, Takamasa| Ninomiya, Toshifumi| Ninomiya, Kiichiro| Tachibana, Kota| Honobe-Tabuchi, Akiko| Muto, Yoshinori| Inozume, Takashi| Ueda, Youki| Ohashi, Kadoaki| Maeda, Yoshinobu| Nagasaki, Joji| Togashi, Yosuke|
Keywords antigenicity cancer immunotherapy CTLA-4 PD-1 regulatory T cell
Published Date 2025-02-27
Publication Title Cancer Science
Volume volume116
Issue issue5
Publisher Wiley
Start Page 1214
End Page 1226
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40017103
DOI 10.1111/cas.70029
Web of Science KeyUT 001479679200005
Related Url isVersionOf https://doi.org/10.1111/cas.70029
FullText URL fulltext.pdf
Author Naganuma, Miyako| Tsuji, Genichiro| Amiya, Misato| Hirai, Reira| Higuchi, Yuki| Hata, Naoko| Nozawa, Saoko| Watanabe, Daishi| Nakajima, Taeko| Demizu, Yosuke|
Published Date 2025-04-30
Publication Title ACS Omega
Publisher American Chemical Society
ISSN 2470-1343
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
DOI 10.1021/acsomega.5c01308
Web of Science KeyUT 001479395700001
Related Url isVersionOf https://doi.org/10.1021/acsomega.5c01308
FullText URL fulltext.pdf
Author Ansai, Satoshi| Hiraki-Kajiyama, Towako| Ueda, Ryutaro| Seki, Takahide| Yokoi, Saori| Katsumura, Takafumi| Takeuchi, Hideaki|
Keywords Evolutionary neuroscience Comparative neuroscience Medaka bioresource Visual mate preference Sexual selection Genetic manipulation
Published Date 2025-05
Publication Title Neuroscience Research
Volume volume214
Publisher Elsevier
Start Page 32
End Page 41
ISSN 0168-0102
NCID AA10641652
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39481546
DOI 10.1016/j.neures.2024.10.005
Web of Science KeyUT 001480873500001
Related Url isVersionOf https://doi.org/10.1016/j.neures.2024.10.005
Title Alternative Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research
Author Uraguchi, Kensuke| Yorifuji, Takashi| Takao, Soshi| Sugaya, Akiko| Ando, Mizuo|
Abstract  Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists.
 Methods : A questionnaire survey was distributed to 34 otolaryngologists with ≤15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research.
 Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research.
 Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement.
Keywords 臨床研究 (clinical research) 統計解析 (statistical analysis) ビッグデータ (bigdata) 質問紙調査 (questionnaire survey)
Publication Title Journal of Okayama Medical Association
Published Date 2025-04-01
Volume volume137
Issue issue1
Start Page 20
End Page 24
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.137.20
language Japanese
Copyright Holders Copyright (c) 2025 岡山医学会
File Version publisher
DOI 10.4044/joma.137.20
Title Alternative The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize)
Author Urata, Tomohiro|
Publication Title Journal of Okayama Medical Association
Published Date 2025-04-01
Volume volume137
Issue issue1
Start Page 7
End Page 9
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.137.7
language Japanese
Copyright Holders Copyright (c) 2025 岡山医学会
File Version publisher
DOI 10.4044/joma.137.7