result 4837 件
FullText URL | fulltext.pdf |
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Author | Haratake, Tomoka| Nishimura, Midori Filiz| Nishikori, Asami| Gonzalez, Michael V.| Ennishi, Daisuke| Lai, You Cheng| Ochi, Sayaka| Tsunoda, Manaka| Fajgenbaum, David C.| van Rhee, Frits| Momose, Shuji| Sato, Yasuharu| |
Keywords | idiopathic multicentric Castleman disease integrin subunit alpha 5 PI3K–Akt signaling pathway platelet-derived growth factor receptor beta vascular endothelial growth factor A vascularity |
Published Date | 2025-08 |
Publication Title | Modern Pathology |
Volume | volume38 |
Issue | issue8 |
Publisher | Elsevier BV |
Start Page | 100782 |
ISSN | 0893-3952 |
NCID | AA1067307X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 THE AUTHORS. |
File Version | publisher |
PubMed ID | 40274066 |
DOI | 10.1016/j.modpat.2025.100782 |
Web of Science KeyUT | 001491556800003 |
Related Url | isVersionOf https://doi.org/10.1016/j.modpat.2025.100782 |
FullText URL | fulltext.pdf |
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Author | Kato, Koji| Kumazawa, Minoru| Nakajima, Yoshiki| Suzuki, Takehiro| Dohmae, Naoshi| Shen, Jian-Ren| Ifuku, Kentaro| Nagao, Ryo| |
Published Date | 2025-05-16 |
Publication Title | Science Advances |
Volume | volume11 |
Issue | issue20 |
Publisher | American Association for the Advancement of Science |
Start Page | eadv7488 |
ISSN | 2375-2548 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. |
File Version | publisher |
PubMed ID | 40378202 |
DOI | 10.1126/sciadv.adv7488 |
Web of Science KeyUT | 001489655000004 |
Related Url | isVersionOf https://doi.org/10.1126/sciadv.adv7488 |
FullText URL | fulltext.pdf |
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Author | Takei, Kensuke| Inokuchi, Toshihiro| Hiraoka, Sakiko| Ishiguro, Mikako| Toyosawa, Junki| Aoyama, Yuki| Igawa, Shoko| Takeuchi, Keiko| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Kawano, Seiji| Mitsuhashi, Toshiharu| Otsuka, Motoyuki| |
Keywords | CD, Crohn's disease LRG, Leucine-rich alpha-2 glycoprotein Fcal, Fecal calprotectin CRP, C-reactive protein ER, Endoscopic remission |
Published Date | 2025-05-13 |
Publication Title | BMC Gastroenterology |
Volume | volume25 |
Issue | issue1 |
Publisher | BMC |
Start Page | 364 |
ISSN | 1471-230X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2025. |
File Version | publisher |
PubMed ID | 40355822 |
DOI | 10.1186/s12876-025-03880-5 |
Web of Science KeyUT | 001488265300002 |
Related Url | isVersionOf https://doi.org/10.1186/s12876-025-03880-5 |
FullText URL | fulltext.pdf |
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Author | La Rocca, Romain| Kato, Koji| Tsai, Pi-Cheng| Nakajima, Yoshiki| Akita, Fusamichi| Shen, Jian-Ren| |
Published Date | 2025-05-05 |
Publication Title | Nature Communications |
Volume | volume16 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 4175 |
ISSN | 2041-1723 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2025 |
File Version | publisher |
PubMed ID | 40325014 |
DOI | 10.1038/s41467-025-59512-9 |
Web of Science KeyUT | 001482932500018 |
Related Url | isVersionOf https://doi.org/10.1038/s41467-025-59512-9 |
JaLCDOI | 10.18926/AMO/68729 |
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FullText URL | 79_3_209.pdf |
Author | Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi| |
Abstract | A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered. |
Keywords | methemoglobinemia aniline methylene blue cyanosis |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2025-06 |
Volume | volume79 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 209 |
End Page | 212 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
JaLCDOI | 10.18926/AMO/68726 |
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FullText URL | 79_3_185.pdf |
Author | Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya| |
Abstract | We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners. |
Keywords | breast cancer patient young patient single partners relationships |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2025-06 |
Volume | volume79 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 185 |
End Page | 195 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
JaLCDOI | 10.18926/AMO/68723 |
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FullText URL | 79_3_157.pdf |
Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
Keywords | advanced glycation end product aging cartilage collagen aggrecan |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2025-06 |
Volume | volume79 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 157 |
End Page | 166 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
Author | Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito| |
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Keywords | adverse event breast cancer pertuzumab trastuzumab VigiBase |
Note | This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025; 1-13. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
Published Date | 2025-05-08 |
Publication Title | British Journal of Clinical Pharmacology |
Publisher | Wiley |
ISSN | 0306-5251 |
NCID | AA00574388 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 British Pharmacological Society. |
File Version | author |
PubMed ID | 40344285 |
DOI | 10.1002/bcp.70094 |
Web of Science KeyUT | 001483932800001 |
Related Url | isVersionOf https://doi.org/10.1002/bcp.70094 |
FullText URL | fulltext.pdf |
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Author | Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara| |
Keywords | animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin |
Published Date | 2025-05-01 |
Publication Title | Infection and Immunity |
Publisher | American Society for Microbiology |
ISSN | 0019-9567 |
NCID | AA00673732 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 Kuriu et al. |
File Version | publisher |
PubMed ID | 40310291 |
DOI | 10.1128/iai.00126-25 |
Web of Science KeyUT | 001479415700001 |
Related Url | isVersionOf https://doi.org/10.1128/iai.00126-25 |
Author | Kawajiri, Takahiro| Hosoya, Masahiro| Goda, Satoshi| Sato, Eisuke| Suga, Seiji| |
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Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.5c01138.| This fulltext file will be available in Apr. 2026.| |
Published Date | 2025-04-29 |
Publication Title | Organic Letters |
Volume | volume27 |
Issue | issue18 |
Publisher | American Chemical Society (ACS) |
Start Page | 4737 |
End Page | 4741 |
ISSN | 1523-7060 |
NCID | AA11347843 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 American Chemical Society |
File Version | author |
PubMed ID | 40302371 |
DOI | 10.1021/acs.orglett.5c01138 |
Web of Science KeyUT | 001479279200001 |
Related Url | isVersionOf https://doi.org/10.1021/acs.orglett.5c01138 |
FullText URL | fulltext.pdf |
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Author | Kuang, Canyan| Hirai, Anna| Kamei‑Νagata, Chiaki| Nango, Hiroshi| Ohtani, Masahiro| Omori, Kazuhiro| Takashiba, Shogo| |
Keywords | AGE experimental periodontitis bone resorption inflammation osteoclasts |
Published Date | 2025-04-11 |
Publication Title | Biomedical Reports |
Volume | volume22 |
Issue | issue6 |
Publisher | Spandidos Publications |
Start Page | 97 |
ISSN | 2049-9434 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | Copyright © 2025 Kuang et al. |
File Version | publisher |
PubMed ID | 40297801 |
DOI | 10.3892/br.2025.1975 |
Web of Science KeyUT | 001477956200001 |
Related Url | isVersionOf https://doi.org/10.3892/br.2025.1975 |
FullText URL | fulltext.pdf |
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Author | Sam, Truong Thao| Somura, Hiroaki| Moroizumi, Toshitsugu| |
Keywords | hydrological model drought coffee irrigation water-saving technique water allocation |
Published Date | 2025 |
Publication Title | Hydrological Research Letters |
Volume | volume19 |
Issue | issue2 |
Publisher | Japan Society of Hydrology and Water Resources |
Start Page | 94 |
End Page | 100 |
ISSN | 1882-3416 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2025. |
File Version | publisher |
DOI | 10.3178/hrl.24-00029 |
Web of Science KeyUT | 001471091300001 |
Related Url | isVersionOf https://doi.org/10.3178/hrl.24-00029 |
FullText URL | fulltext.pdf |
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Author | Maruo, Yukinori| Kuwahara, Miho| Yoshihara, Kumiko| Irie, Masao| Nagaoka, Noriyuki| Yoshizane, Mai| Matsumoto, Takuya| Akiyama, Kentaro| |
Keywords | silane coupling bond strength ceramic feldspathic lithium polymer-infiltrated ceramic CAD/CAM |
Published Date | 2025-04-27 |
Publication Title | Materials |
Volume | volume18 |
Issue | issue9 |
Publisher | MDPI |
Start Page | 1983 |
ISSN | 1996-1944 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 by the authors. |
File Version | publisher |
PubMed ID | 40363487 |
DOI | 10.3390/ma18091983 |
Web of Science KeyUT | 001486402200001 |
Related Url | isVersionOf https://doi.org/10.3390/ma18091983 |
FullText URL | fulltext.pdf |
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Author | Dong, Yubing| Wang, Guohao| Ujihara, Yoshihiro| Chen, Yanzhu| Yoshida, Masashi| Nakamura, Kazufumi| Katanosaka, Kimiaki| Naruse, Keiji| Katanosaka, Yuki| |
Published Date | 2025-05-08 |
Publication Title | Communications Biology |
Volume | volume8 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 715 |
ISSN | 2399-3642 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2025 |
File Version | publisher |
PubMed ID | 40341813 |
DOI | 10.1038/s42003-025-08167-9 |
Web of Science KeyUT | 001485486400005 |
Related Url | isVersionOf https://doi.org/10.1038/s42003-025-08167-9 |
FullText URL | fulltext.pdf |
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Author | Takatori, S.| Pimon, M.| Pollitt, S.| Bartokos, M.| Beeks, K.| Grueneis, A.| Hiraki, T.| Honma, T.| Hosseini, N.| Leitner, A.| Masuda, T.| Morawetz, I| Nitta, K.| Okai, K.| Riebner, T.| Schaden, F.| Schumm, T.| Sekizawa, O.| Sikorsky, T.| Takahashi, Y.| De Col, Col, L. Toscani| Yamamoto, R.| Yomogida, T.| Yoshimi, A.| Yoshimura, K.| |
Keywords | solid-state nuclear clock thorium-229 XAFS |
Published Date | 2025-04-28 |
Publication Title | New Journal of Physics |
Volume | volume27 |
Issue | issue4 |
Publisher | IOP Publishing |
Start Page | 043024 |
ISSN | 1367-2630 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 The Author(s). |
File Version | publisher |
DOI | 10.1088/1367-2630/adce22 |
Web of Science KeyUT | 001477975100001 |
Related Url | isVersionOf https://doi.org/10.1088/1367-2630/adce22 |
FullText URL | fulltext.pdf |
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Author | Matsuura, Hiroaki| Ishino, Takamasa| Ninomiya, Toshifumi| Ninomiya, Kiichiro| Tachibana, Kota| Honobe-Tabuchi, Akiko| Muto, Yoshinori| Inozume, Takashi| Ueda, Youki| Ohashi, Kadoaki| Maeda, Yoshinobu| Nagasaki, Joji| Togashi, Yosuke| |
Keywords | antigenicity cancer immunotherapy CTLA-4 PD-1 regulatory T cell |
Published Date | 2025-02-27 |
Publication Title | Cancer Science |
Volume | volume116 |
Issue | issue5 |
Publisher | Wiley |
Start Page | 1214 |
End Page | 1226 |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 The Author(s). |
File Version | publisher |
PubMed ID | 40017103 |
DOI | 10.1111/cas.70029 |
Web of Science KeyUT | 001479679200005 |
Related Url | isVersionOf https://doi.org/10.1111/cas.70029 |
FullText URL | fulltext.pdf |
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Author | Naganuma, Miyako| Tsuji, Genichiro| Amiya, Misato| Hirai, Reira| Higuchi, Yuki| Hata, Naoko| Nozawa, Saoko| Watanabe, Daishi| Nakajima, Taeko| Demizu, Yosuke| |
Published Date | 2025-04-30 |
Publication Title | ACS Omega |
Publisher | American Chemical Society |
ISSN | 2470-1343 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2025 The Authors. |
File Version | publisher |
DOI | 10.1021/acsomega.5c01308 |
Web of Science KeyUT | 001479395700001 |
Related Url | isVersionOf https://doi.org/10.1021/acsomega.5c01308 |
FullText URL | fulltext.pdf |
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Author | Ansai, Satoshi| Hiraki-Kajiyama, Towako| Ueda, Ryutaro| Seki, Takahide| Yokoi, Saori| Katsumura, Takafumi| Takeuchi, Hideaki| |
Keywords | Evolutionary neuroscience Comparative neuroscience Medaka bioresource Visual mate preference Sexual selection Genetic manipulation |
Published Date | 2025-05 |
Publication Title | Neuroscience Research |
Volume | volume214 |
Publisher | Elsevier |
Start Page | 32 |
End Page | 41 |
ISSN | 0168-0102 |
NCID | AA10641652 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2024 The Author(s). |
File Version | publisher |
PubMed ID | 39481546 |
DOI | 10.1016/j.neures.2024.10.005 |
Web of Science KeyUT | 001480873500001 |
Related Url | isVersionOf https://doi.org/10.1016/j.neures.2024.10.005 |
Title Alternative | Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research |
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Author | Uraguchi, Kensuke| Yorifuji, Takashi| Takao, Soshi| Sugaya, Akiko| Ando, Mizuo| |
Abstract | Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists. Methods : A questionnaire survey was distributed to 34 otolaryngologists with ≤15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research. Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research. Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement. |
Keywords | 臨床研究 (clinical research) 統計解析 (statistical analysis) ビッグデータ (bigdata) 質問紙調査 (questionnaire survey) |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2025-04-01 |
Volume | volume137 |
Issue | issue1 |
Start Page | 20 |
End Page | 24 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.137.20 |
language | Japanese |
Copyright Holders | Copyright (c) 2025 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.137.20 |
Title Alternative | The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize) |
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Author | Urata, Tomohiro| |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2025-04-01 |
Volume | volume137 |
Issue | issue1 |
Start Page | 7 |
End Page | 9 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.137.7 |
language | Japanese |
Copyright Holders | Copyright (c) 2025 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.137.7 |