start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251113 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=First Total Synthesis of the Kikai Island Polybrominated C3БМ?N1 Bisindole Alkaloid by a Directed Metalation Strategy en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first total synthesis of one out of four Kikai Island polybrominated C3БМ?N1 bisindole alkaloids from red alga Laurencia brongniartii is described. The key steps involve both dehydration of trans-hemiaminal and a C2БМ-methylthiolation of bisindole using dimethyl disulfide through directed metalation, followed by C3-methylthiolation using a N-SMe succinimide reagent. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=68 article-no= start-page=12801 end-page=12804 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Revisiting 3-azidoindoles: overcoming the trade-off challenges between stability and reactivity of in situ-generated azidoindoles en-subtitle= kn-subtitle= en-abstract= kn-abstract=A concise protocol based on the E2 reaction of indoline hemiaminals for accessing 3-azidoindoles is reported. In contrast to previous methods that require in situ generation by hypervalent iodine reagents, our protocol allows for the isolation of a variety of 3-azidoindoles upon a mild reaction for a short reaction time at room temperature. The obtained 3-azidoindoles are reasonably reactive, bench-stable and easy to handle. These findings could be used as a starting point for various reactions, including Huisgen reaction, [3+2] cycloaddition, phosphoramidation, and cine-substitution with the release of N2. en-copyright= kn-copyright= en-aut-name=AsaiShota en-aut-sei=Asai en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=School of Pharmacy, Shujitsu University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=5 article-no= start-page=271 end-page=277 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Japan MSA registry: A multicenter cohort study of multiple system atrophy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure and various motor symptoms. While MSA-C (cerebellar type) predominates in East Asia, MSA-P (parkinsonian type) predominates in Europe and North America. This nationwide patient registry aimed to (1) conduct a prospective natural history study of MSA in Japan, (2) facilitate patient recruitment for clinical trials, and (3) deposit bioresources and clinical information in a biobank.
Methods: Thirteen institutions participated in this study. Clinical information was obtained by neurologists from the patients visiting the hospital every 12?months to assess the UMSARS Part 2 scores and by telephone interviews by nurses every 6?months to assess UMSARS Part 1 scores and to determine whether clinical events had occurred.
Results: Demographic data from 329 MSA patients (216 MSA-C and 113 MSA-P) were analyzed. The mean age at symptom onset was 58.2?years (standard deviation, 8.9); the mean duration of symptoms at enrollment was 3.5?years (standard deviation, 2.2). The mean 12-month changes in the UMSARS Part 1 and Part 2 scores were 7.9 (standard deviation, 5.6) and 6.4 (standard deviation, 5.9), respectively. The patient registry proved useful in recruiting participants for clinical trials, including those with gene variants. Clinical information and biospecimens were deposited in a biobank.
Discussion: The study highlighted the importance of telephone interviews in minimizing drop-out rates in natural history studies and demonstrated similar MSA progression rates across populations. The deposited bioresources are available to researchers upon request, aiming to contribute to future MSA researches. en-copyright= kn-copyright= en-aut-name=ChikadaAyaka en-aut-sei=Chikada en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OrimoKenta en-aut-sei=Orimo en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsuiJun en-aut-sei=Mitsui en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsukawaTakashi en-aut-sei=Matsukawa en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TodaTatsushi en-aut-sei=Toda en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MizusawaHidehiro en-aut-sei=Mizusawa en-aut-mei=Hidehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakahashiYuji en-aut-sei=Takahashi en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatsunoMasahisa en-aut-sei=Katsuno en-aut-mei=Masahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HaraKazuhiro en-aut-sei=Hara en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OnoderaOsamu en-aut-sei=Onodera en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IshiharaTomohiko en-aut-sei=Ishihara en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TadaMasayoshi en-aut-sei=Tada en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KuwabaraSatoshi en-aut-sei=Kuwabara en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=SugiyamaAtsuhiko en-aut-sei=Sugiyama en-aut-mei=Atsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YamanakaYoshitaka en-aut-sei=Yamanaka en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=TakahashiRyosuke en-aut-sei=Takahashi en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=SawamotoNobukatsu en-aut-sei=Sawamoto en-aut-mei=Nobukatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=SakatoYusuke en-aut-sei=Sakato en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=IshimotoTomoyuki en-aut-sei=Ishimoto en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=HanajimaRitsuko en-aut-sei=Hanajima en-aut-mei=Ritsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=WatanabeYasuhiro en-aut-sei=Watanabe en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=TakigawaHiroshi en-aut-sei=Takigawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=AdachiTadashi en-aut-sei=Adachi en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=TakashimaHiroshi en-aut-sei=Takashima en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=HigashiKeiko en-aut-sei=Higashi en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= en-aut-name=KiraJunichi en-aut-sei=Kira en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=29 ORCID= en-aut-name=YabeIchiro en-aut-sei=Yabe en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=30 ORCID= en-aut-name=MatsushimaMasaaki en-aut-sei=Matsushima en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=31 ORCID= en-aut-name=OgataKatsuhisa en-aut-sei=Ogata en-aut-mei=Katsuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=32 ORCID= en-aut-name=IshikawaKinya en-aut-sei=Ishikawa en-aut-mei=Kinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=33 ORCID= en-aut-name=NishidaYoichiro en-aut-sei=Nishida en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=34 ORCID= en-aut-name=IshiguroTaro en-aut-sei=Ishiguro en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=35 ORCID= en-aut-name=OzakiKokoro en-aut-sei=Ozaki en-aut-mei=Kokoro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=36 ORCID= en-aut-name=NagataTetsuya en-aut-sei=Nagata en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=37 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=38 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=9 en-affil=Department of Neurology, Nagoya University Graduate School of Medicine kn-affil= affil-num=10 en-affil=Department of Neurology, Nagoya University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Neurology, Brain Research Institute, Niigata University kn-affil= affil-num=12 en-affil=Department of Neurology, Brain Research Institute, Niigata University kn-affil= affil-num=13 en-affil=Department of Neurology, Brain Research Institute, Niigata University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Chiba University kn-affil= affil-num=15 en-affil=Department of Neurology, Graduate School of Medicine, Chiba University kn-affil= affil-num=16 en-affil=Department of Neurology, Graduate School of Medicine, Chiba University kn-affil= affil-num=17 en-affil=Department of Neurology, Kyoto University Graduate School of Medicine kn-affil= affil-num=18 en-affil=Department of Human Health Sciences, Kyoto University Graduate School of Medicine kn-affil= affil-num=19 en-affil=Department of Neurology, Kyoto University Graduate School of Medicine kn-affil= affil-num=20 en-affil=Department of Neurology, Kyoto University Graduate School of Medicine kn-affil= affil-num=21 en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University kn-affil= affil-num=22 en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University kn-affil= affil-num=23 en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University kn-affil= affil-num=24 en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University kn-affil= affil-num=25 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=26 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=27 en-affil=Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University kn-affil= affil-num=28 en-affil=Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University kn-affil= affil-num=29 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=30 en-affil=Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=31 en-affil=Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=32 en-affil=Department of Neurology, Higashi-Saitama National Hospital kn-affil= affil-num=33 en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University kn-affil= affil-num=34 en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University kn-affil= affil-num=35 en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University kn-affil= affil-num=36 en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University kn-affil= affil-num=37 en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University kn-affil= affil-num=38 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= en-keyword=multicenter cohort study kn-keyword=multicenter cohort study en-keyword=multiple system atrophy kn-keyword=multiple system atrophy en-keyword=natural history kn-keyword=natural history en-keyword=patient registry kn-keyword=patient registry END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Revisiting 3-azidoindoles: overcoming the trade-off challenges between stability and reactivity of in situ-generated azidoindoles en-subtitle= kn-subtitle= en-abstract= kn-abstract=A concise protocol based on the E2 reaction of indoline hemiaminals for accessing 3-azidoindoles is reported. In contrast to previous methods that require in situ generation by hypervalent iodine reagents, our protocol allows for the isolation of a variety of 3-azidoindoles upon a mild reaction for a short reaction time at room temperature. The obtained 3-azidoindoles are reasonably reactive, bench-stable and easy to handle. These findings could be used as a starting point for various reactions, including Huisgen reaction, [3+2] cycloaddition, phosphoramidation, and cine-substitution with the release of N2. en-copyright= kn-copyright= en-aut-name=AsaiShota en-aut-sei=Asai en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=School of Pharmacy, Shujitsu University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=One-pot synthesis of trans-2,3-diaminoindolines through 2,3-diamination of electrophilic indolines en-subtitle= kn-subtitle= en-abstract= kn-abstract=Despite recent advances in the synthesis of 2,3-diaminoindole derivatives, construction of 2,3-diaminoindolines, whose two amine moieties on each molecule differ from one another has yet to be achieved. In this work, we developed a concise one-pot protocol for differentiated diamination involving reacting a C2,C3-electrophilic indole reagent with amines to access a variety of previously inaccessible 2,3-diaminoindolines. Furthermore, the synthetic utility of this protocol was demonstrated by a successful gram-scale reaction and further transformation of the 2,3-diaminoindolines. en-copyright= kn-copyright= en-aut-name=KoboriYuito en-aut-sei=Kobori en-aut-mei=Yuito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=e202500439 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=2-Hydroxy-3-(Pyrrolidin-1-yl)-Indolines: A Platform for Accessing Decorated Deaminokynurenines Enabled by a Double Tautomeric Control en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study we introduce indoline hemiaminals as phenacyl bromide surrogates for the synthesis of deaminokynurenine derivatives through cyclic-linear tautomeric intermediates. The reaction proceeds through a tandem process involving the ring opening of indoline hemiaminals, generating transient acyclic aldehydes which are then trapped with in situ generated enolate species. Our protocol overcomes traditional dilemma in production of polar-mismatch 1,4-dicarbonyl compounds by utilizing a transient highly electrophilic linear aldehyde and late-stage transposition of carbonyl moiety. The synthetic utility of our transformation was demonstrated by follow-up transformations, including the first total synthesis of quinoline-2,4-dione alkaloid. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Deaminokynurenines kn-keyword=Deaminokynurenines en-keyword=Enolates kn-keyword=Enolates en-keyword=Indoline hemiaminals kn-keyword=Indoline hemiaminals en-keyword=Potassium tertbutoxide kn-keyword=Potassium tertbutoxide en-keyword=Tautomerism kn-keyword=Tautomerism END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=43 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Molecular Iodine-Catalyzed Synthesis of 3,3-Disubstituted Isatins: Total Synthesis of Indole Alkaloid, 3,3-Dimethoxy-2-oxindole en-subtitle= kn-subtitle= en-abstract= kn-abstract=3,3-Dialkoxy-2-oxindoles are prevalent in natural products and exhibit unique biological activities. Among them, acyclic alkoxy analogues show instability in acidic conditions, making access to acyclic isatin ketals highly challenging. Conventional methods for the synthesis of 3,3-dialkoxy-2-oxindoles usually require strongly acidic and harsh reaction conditions, resulting in a low overall efficiency. Herein, we report on an acid- and metal-free protocol for the synthesis of 3,3-dialkoxy-2-oxindoles from isatins through an iodine-catalyzed ketalization. This photochemical protocol does not require the use of any specific reagents such as metal catalysts. Furthermore, the total synthesis of an unprecedented 2-oxindole alkaloid bearing 3,3-dimethoxy moiety is achieved. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AsaiShota en-aut-sei=Asai en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=School of Pharmacy, Shujitsu University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=3,3-dialkoxyisatins kn-keyword=3,3-dialkoxyisatins en-keyword=isatins kn-keyword=isatins en-keyword=ketalization kn-keyword=ketalization en-keyword=iodine kn-keyword=iodine en-keyword=indole alkaloid kn-keyword=indole alkaloid END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=2 article-no= start-page=e202400552 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241217 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Potassium tert-Butoxide-Mediated Ring-Opening of Indolines: Concise Synthesis of 2-Vinylanilines en-subtitle= kn-subtitle= en-abstract= kn-abstract=A concise and metal-free procedure has been developed for the synthesis of 2-vinylanilines. Reactions of indolines with tert-BuOK in DMSO afford the decorated 2-vinylanilines in yields up to 92?%. In addition, the 2, or 3-substituted indolines could be converted to trisubstituted alkenes. Also, the protocol can be scaled to afford gram quantities of the decorated 2-vinylanilines. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AsaiShota en-aut-sei=Asai en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=School of Pharmacy, Shujitsu University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=2-vinylanilines kn-keyword=2-vinylanilines en-keyword=indolines kn-keyword=indolines en-keyword=Potassium tert-butoxide kn-keyword=Potassium tert-butoxide en-keyword=Elimination kn-keyword=Elimination en-keyword=Ring-opening kn-keyword=Ring-opening END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=TН╫ЦEОюсЗВ╔ВиВпВщГ┐-ГsГlГУВ╠НRОюсЗКИРл kn-title=Antitumor activity of Г┐-pinene in T-cell tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ABEMasaya en-aut-sei=ABE en-aut-mei=Masaya kn-aut-name=ИвХФПлЦч kn-aut-sei=ИвХФ kn-aut-mei=ПлЦч aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚ END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=36 article-no= start-page=7343 end-page=7348 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Indoline hemiaminals: a platform for accessing anthranilic acid derivatives through oxidative deformylation en-subtitle= kn-subtitle= en-abstract= kn-abstract=2-Aminobenzoyl chlorides possess both a nucleophilic nitrogen atom and an electrophilic carbonyl group, and thus selective acylation of nucleophiles is challenging; self-dimerization and sluggish reactions occur. Herein, we introduce a new synthetic protocol using 2-aminobenzoyl surrogates, allowing concise entry to decorated 2-aminobenzoyl derivatives in the absence of transition metals, acid chlorides, and specific reagents. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KoboriYuito en-aut-sei=Kobori en-aut-mei=Yuito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsaiShota en-aut-sei=Asai en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=School of Pharmacy, Shujitsu University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=20521 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia en-subtitle= kn-subtitle= en-abstract= kn-abstract=The therapeutic potential of suppressing polypyrimidine tract-binding protein 1 (Ptbp1) messenger RNA by viral transduction in a post-stroke dementia mouse model has not yet been examined. In this study, 3 days after cerebral ischemia, we injected a viral vector cocktail containing adeno-associated virus (AAV)-pGFAP-mCherry and AAV-pGFAP-CasRx (control vector) or a cocktail of AAV-pGFAP-mCherry and AAV-pGFAP-CasRx-SgRNA-(Ptbp1) (1:5, 1.0 x 1011 viral genomes) into post-stroke mice via the tail vein. We observed new mCherry/NeuN double-positive neuron-like cells in the hippocampus 56 days after cerebral ischemia. A portion of mCherry/GFAP double-positive astrocyte-like glia could have been converted into new mCherry/NeuN double-positive neuron-like cells with morphological changes. The new neuronal cells integrated into the dentate gyrus and recognition memory was significantly ameliorated. These results demonstrated that the in vivo conversion of hippocampal astrocyte-like glia into functional new neurons by the suppression of Ptbp1 might be a therapeutic strategy for post-stroke dementia. en-copyright= kn-copyright= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=CasRx kn-keyword=CasRx en-keyword=Hippocampal neurogenesis kn-keyword=Hippocampal neurogenesis en-keyword=In vivo direct reprogramming kn-keyword=In vivo direct reprogramming en-keyword=Ischemic stroke kn-keyword=Ischemic stroke en-keyword=PHP.eB kn-keyword=PHP.eB en-keyword=Ptbp1 kn-keyword=Ptbp1 en-keyword=Recognition memory kn-keyword=Recognition memory END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=4 article-no= start-page=556 end-page=580 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240718 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Azidoindolines?From Synthesis to Application: A Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Azide-containing compounds, organic azides, showcases a variety of reactivities, making them highly convenient and chameleonic intermediates. An indoline derivative has been proven to be of great significance in drug discovery due to its sp3-rich property. In this context, it is interesting to perform such vigorous azidation on medicinal-relevant indoles/indolines, resulting in the production of sp3-rich azidoindolines. The potential biological activity, in combination with the sp3-rich indoline bearing the azido moiety, makes azidoindolines an attractive synthetic target for medicinal and synthetic chemists. This review describes recent advances in the synthesis and application of azidoindolines: (1) iodine-mediated azidations, (2) metal-catalyzed azidations, (3) electrochemical azidations, (4) photochemical azidations, (5) azidation using a combination of an oxidant and an azide source, and (6) nucleophilic azidation. en-copyright= kn-copyright= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=azidoindolines kn-keyword=azidoindolines en-keyword=indole kn-keyword=indole en-keyword=azido kn-keyword=azido en-keyword=synthesis kn-keyword=synthesis en-keyword=application kn-keyword=application END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=14 article-no= start-page=10349 end-page=10354 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formal One Carbon Deletion of Indoline Hemiaminals under Tautomeric Control to Access 2-Aminobenzyl Compounds en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unprecedented tert-BuOK-mediated one carbon deletion of indoline hemiaminals has been achieved. This novel protocol provides an efficient synthetic tool for the construction of 2-aminobenzyl compounds with high chemoselectivity. In addition, functionalized 2-aminobenzyl compounds are difficult to make, for which few limited means of access currently exist. The key to success is the use of in situ generated Heyns rearrangement products (Г┐-amino carbonyl compounds) as precursors for formal one carbon deletion. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=1 article-no= start-page=219 end-page=228 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Novel Peptidome Technology for the Diagnosis of Mild Cognitive Impairment and AlzheimerБfs Disease by Selected Reaction Monitoring en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background:With the aging of populations worldwide, AlzheimerБfs disease (AD) has become a concern due to its high prevalence and the continued lack of established treatments. Early diagnosis is required as a preventive intervention to modify the diseaseБfs progression. In our previous study, we performed peptidomic analysis of serum samples obtained from AD patients and age-matched healthy subjects to seek peptide biomarker candidates for AD by using BLOTCHIP-MS analysis, and identified four peptides as AD biomarker candidates.
Objective:The objective was to validate the serum biomarker peptides to distinguish mild cognitive impairment (MCI) and AD in comparison to cognitively healthy controls using a new peptidome technology, the Dementia Risk Test.
Methods:We enrolled 195 subjects with normal cognitive function (NC; n?=?70), MCI (n?=?55), and AD (n?=?70), The concentrations of cognitive impairment marker peptides (Fibrinogen Г┐ chain (FAC), Fibrinogen Г└ chain (FBC), Plasma protease C1 inhibitor (PPC1I), Г┐2-HS-glycoprotein (AHSG)) were quantified by using a selected reaction monitoring assay based on liquid chromatography-MS/MS.
Results:The present study confirmed that three peptides, FAC, FBC, and PPC1I, were significantly upregulated during the onset of AD. This three-peptide set was both highly sensitive in determining AD (sensitivity: 85.7%, specificity: 95.7%, AUC: 0.900) and useful in distinguishing MCI (sensitivity: 61.8%, specificity: 98.6%, AUC: 0.824) from NC.
Conclusions:In this validation study, we confirmed the high diagnostic potential of the three peptides identified in our previous study as candidate serum biomarkers for AD. The Dementia Risk Test may be a powerful tool for detecting AD-related pathological changes. en-copyright= kn-copyright= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaMinaki en-aut-sei=Hamada en-aut-mei=Minaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsadaKyoichi en-aut-sei=Asada en-aut-mei=Kyoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LeeLyang-Ja en-aut-sei=Lee en-aut-mei=Lyang-Ja kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TachikiHidehisa en-aut-sei=Tachiki en-aut-mei=Hidehisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Protosera, Inc. kn-affil= affil-num=4 en-affil=Protosera, Inc. kn-affil= affil-num=5 en-affil=Protosera, Inc. kn-affil= affil-num=6 en-affil=Protosera, Inc. kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, National Center of Neurology and Psychiatry kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=AlzheimerБfs disease kn-keyword=AlzheimerБfs disease en-keyword=biochemical marker kn-keyword=biochemical marker en-keyword=dementia risk test kn-keyword=dementia risk test en-keyword=liquid chromatography-MS/MS kn-keyword=liquid chromatography-MS/MS en-keyword=mild cognitive impairment kn-keyword=mild cognitive impairment en-keyword=peptidome kn-keyword=peptidome en-keyword=selected reaction monitoring kn-keyword=selected reaction monitoring END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=52 article-no= start-page=6615 end-page=6618 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Switchable synthesis of 3-aminoindolines and 2БМ-aminoarylacetic acids using Grignard reagents and 3-azido-2-hydroxyindolines en-subtitle= kn-subtitle= en-abstract= kn-abstract=The switchable synthesis of 3-aminoindolines and 2БМ-aminoaryl acetic acids from the same substrates, 3-azido-2-hydroxyindolines, was developed through denitrogenative electrophilic amination of Grignard reagents. The key to success is the serendipitous discovery that the reaction conditions, including solvents and reaction temperature, can affect the chemoselectivity. It is noteworthy that isotope-labeling experiments revealed the occurrence of the aziridine intermediate in the production of 2БМ-aminoaryl acetic acids. en-copyright= kn-copyright= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University kn-title=КwМ|ИїЙ█ТЎ Newsletter Сц14НЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=МїЦ{ПЗ kn-aut-sei=МїЦ{ kn-aut-mei=ПЗ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФР╜Мх kn-aut-sei=ИвХФ kn-aut-mei=Р╜Мх aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Ц╝С║ЦГЧRОq kn-aut-sei=Ц╝С║ kn-aut-mei=ЦГЧRОq aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ОсОRСПЧ╟ kn-aut-sei=ОсОR kn-aut-mei=СПЧ╟ aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=П╝ФЎХPУ▐ kn-aut-sei=П╝ФЎ kn-aut-mei=ХPУ▐ aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИюЦ╤Н╣Мb kn-aut-sei=ИюЦ╤ kn-aut-mei=Н╣Мb aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Х╢КwХФ affil-num=2 en-affil= kn-affil=Х╢КwХФ ЧЁОjКwБEНlМ├КwХкЦь affil-num=3 en-affil= kn-affil=Х╢КwХФ У·Ц{МъБEУ·Ц{Х╢КwХкЦь affil-num=4 en-affil= kn-affil=Х╢КwХФ ЧЁОjКwБEНlМ├КwХкЦь affil-num=5 en-affil= kn-affil=Х╢КwХФ ЧЁОjКwБEНlМ├КwХкЦь affil-num=6 en-affil= kn-affil=Х╢КwХФ ТnЧЭКwБEО╨ЙяКwБEХ╢Й╗РlЧ▐КwБEО╨ЙяХ╢Й╗КwХкЦь END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=47 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Implementation and Evaluation of Teacher Training on Food Allergy Education in Kindergarten Б\ Aiming to Foster Children Leading Healthy Lives, Regardless of the Presence of Food Allergies Б\ kn-title=ЧcТtЙАВ╔ВиВпВщРHХиГAГМГЛГMБ[Л│ИчВ╔К╓В╖ВщЛ│ИїМдПCВ╠О└О{В╞В╗В╠Х]Й┐Б@РHХиГAГМГЛГMБ[В╠ЧLЦ│В╔К╓ВэВчВ╕БCРSРgЛдВ╔МТНNВ╚Р╢КИВЁСЧВщОqЛЯВ╠ИчРмВЁВ▀В┤В╡В─ en-subtitle= kn-subtitle= en-abstract=This study aims to explore strategies for nurturing kindergarten children with food allergies. Teacher training on food allergy education was conducted, and its effectiveness was evaluated based on teacher reactions and pre- and post-training surveys. The training deepened the understanding of the importance of addressing the emotional needs of children with food allergies. Case studies revealed the necessity of conveying this understanding to preschoolers and equipping them to respond appropriately. The study also observed teachers navigating between traditional and evolving educational perspectives, with observed fluctuations and conflicts contributing to refining teachers' beliefs tow ard embracing individual needs and diversity. kn-abstract=Б@Ц{МдЛЖВ╠Ц┌УIВ═БCЧcТtЙАВ╔ВиВвВ─РHХиГAГМГЛГMБ[В╞ЛдВ╔Р╢КИВ╖ВщОqЛЯВЁИчВ▐Х√НЇВЁМЯУвВ╖ВщВ▒В╞В┼ВаВщБBЦ{МдЛЖВ┼В═БCРHХиГAГМГЛГMБ[Л│ИчВ╔К╓В╖ВщЛ│ИїМдПCВЁНsВвБCМдПCТЖВ╠Л│ИїВ╠Ф╜ЙЮВ╞МдПCСOМуВ╠ГAГУГPБ[ГgТ▓Н╕В╠МЛЙ╩ВЁКюВ╔БCВ╗В╠М°Й╩ВЁХ]Й┐В╡В╜БB
Б@МдПCМуВ╔В═,РHХиГAГМГЛГMБ[ВтВ╗В╠С╬ЙЮВ╔ВцВ┴В─Р╢В╢ВщОqЛЯТBВ╠РSЛлВ╓ВрЦ┌ВЁМ№ВпВщХKЧvРлВ╠ЧЭЙЁВкР[В▄В┴В╜БBВ▄В╜ОЦЧсМЯУвВЁТ╩В╡В─БCЧcТtЙАВ╔ВиВвВ─ВрЧcОЩВ╚ВшВ╔РHХиГAГМГЛГMБ[ВЁЧЭЙЁВ╡В─С╬ЙЮВ┼ВлВщВцВдВ╔У`ВжВщХKЧvРлВкВаВщВ╞Ц╛ВчВйВ╔В╚ВшБCО└Н█В╔ОwУ▒В┼ВлВ╗ВдВ╚ЛяС╠УIВ╚ПъЦ╩ВрЛУВ░ВчВъВ╜БBВ│ВчВ╔МдПCТЖБCЦмБXВ╞ОєВпМpВкВъВ─ВлВ╜БgЛ│ИчК╧БhВ╞БCМ╗Н▌В╠С╜ЧlЙ╗В╡В╜ОЮСуФwМiВтОqЛЯТBВ╠О└С╘БCО╨ЙяУIВ╚В┬В╚ВкВшВЁУеВ▄ВжВ─НXРVВ│ВъВщБgЛ│ИчК╧БhВ╠ТЖВ┼ЧhВъУоВнЛ│ИїВ╠ОpВкМйВчВъБCВ╗В╠ЧhВчВмВтКЛУбОйС╠ВкБCМ┬Х╩В╠ГjБ[ГYВЁУKР╪В╔ОєВпУ№ВъБCС╜ЧlРлВЁС╕ПdВ╖ВщЛ│ОtВ╠К╧ФOВЁЦБВнВ▒В╞В╔В┬В╚ВкВ┴В─ВвВщВ╞НlВжВчВъВ╜БB en-copyright= kn-copyright= en-aut-name=SHINTAKUYumiko en-aut-sei=SHINTAKU en-aut-mei=Yumiko kn-aut-name=РVСюЧRО└Оq kn-aut-sei=РVСю kn-aut-mei=ЧRО└Оq aut-affil-num=1 ORCID= en-aut-name=IYAMAFusako en-aut-sei=IYAMA en-aut-mei=Fusako kn-aut-name=ИфОRЦ[Оq kn-aut-sei=ИфОR kn-aut-mei=Ц[Оq aut-affil-num=2 ORCID= en-aut-name=KUROSUMIChiyo en-aut-sei=KUROSUMI en-aut-mei=Chiyo kn-aut-name=НХПZТmСу kn-aut-sei=НХПZ kn-aut-mei=ТmСу aut-affil-num=3 ORCID= en-aut-name=ABEKouhei en-aut-sei=ABE en-aut-mei=Kouhei kn-aut-name=ИвХФНkХ╜ kn-aut-sei=ИвХФ kn-aut-mei=НkХ╜ aut-affil-num=4 ORCID= en-aut-name=KOTANIKayo en-aut-sei=KOTANI en-aut-mei=Kayo kn-aut-name=ПмТJНБСу kn-aut-sei=ПмТJ kn-aut-mei=НБСу aut-affil-num=5 ORCID= en-aut-name=TAKATORIMayumi en-aut-sei=TAKATORI en-aut-mei=Mayumi kn-aut-name=СщОцЦЬЧFФ№ kn-aut-sei=СщОц kn-aut-mei=ЦЬЧFФ№ aut-affil-num=6 ORCID= en-aut-name=OKADAKeita en-aut-sei=OKADA en-aut-mei=Keita kn-aut-name=ЙкУcМbС╛ kn-aut-sei=ЙкУc kn-aut-mei=МbС╛ aut-affil-num=7 ORCID= en-aut-name=TANAKAMaho en-aut-sei=TANAKA en-aut-mei=Maho kn-aut-name=УcТЖР^Ф┐ kn-aut-sei=УcТЖ kn-aut-mei=Р^Ф┐ aut-affil-num=8 ORCID= en-aut-name=MIKISaori en-aut-sei=MIKI en-aut-mei=Saori kn-aut-name=ОOЦ╪Н╩РD kn-aut-sei=ОOЦ╪ kn-aut-mei=Н╩РD aut-affil-num=9 ORCID= affil-num=1 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=2 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=3 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=4 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=5 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=6 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=7 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=8 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА affil-num=9 en-affil=Kindergarten Attached to the School Education, Okayama University kn-affil=ЙкОRСхКwЛ│ИчКwХФХНСоЧcТtЙА en-keyword=РHХиГAГМГЛГMБ[Л│Ич (Food Allergy Education) kn-keyword=РHХиГAГМГЛГMБ[Л│Ич (Food Allergy Education) en-keyword=РHХиГAГМГЛГMБ[МдПC (Food Allergy Training) kn-keyword=РHХиГAГМГЛГMБ[МдПC (Food Allergy Training) en-keyword=ЧcТtЙА (Kindergarten) kn-keyword=ЧcТtЙА (Kindergarten) en-keyword=Л│ИїМдПC (Teacher Training) kn-keyword=Л│ИїМдПC (Teacher Training) en-keyword=С╜ЧlРл (Diversity) kn-keyword=С╜ЧlРл (Diversity) END start-ver=1.4 cd-journal=joma no-vol=185 cd-vols= no-issue= article-no= start-page=53 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rerationship between the Lows and Transition of Elementary Schools with the Handicraft Course in Ehime and Tokyo (Second Part) : History of Handicraft Education in Ehime (V) kn-title=ИдХQМзВ╞УМЛЮУsВ╔ВиВпВщЦ@Ч▀В╞ОшНHЙ╚Й┴Р▌НZВ╠Х╧СJВ╞В╠К╓ШAРлБiМуХ╥БjБ\ ИдХQМзОшНHЛ│ИчОjБiСцМ▄ХёБj Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Б@Ц{Ш_В┼В═БCИвХФО╡М▄ОOЛgБi1936БjВ╔ВцВщБuОшНHЛ│ИчКюСbМЪР▌В╠ПММїОЮСуБvБm1907БiЦ╛Об40БjФNНаБ` 1926БiСхР│15БjФNНаВ▄В┼БnВ╠20 ФNК╘ВЁТ▓Н╕С╬П█К·К╘В╞В╡В─БCПмКwНZОшНHЙ╚К╓МWВ╠Ц@Ч▀ПЁХ╢УЩВЁХкР═В╡БCЦ@Ч▀Й№Р│В╔СеВ╡В─БwУ·Ц{ТщНСХ╢ХФП╚ФNХёБxВЁКюВ╔ИдХQМзВ╠ОшНHЙ╚Й┴Р▌НZВ╠РФЧ╩УIВ╚Х╧СJВЁУМЛЮУsВ╞ФфКrМЯУвВ╖ВщВ▒В╞В╔ВцВ┴В─БCИдХQМзВ╠РqПэПмКwНZВ╞НВУЩПмКwНZВ╔ВиВпВщОшНHЙ╚В╠УWКJЙ▀ТЎВЁТTВ┴В╜БBВ╗В╠МЛЙ╩БCБi1БjЦ@Ч▀ПЁХ╢УЩВ╔ВиВпВщРqПэПмКwНZВ╞НВУЩПмКwНZВ╠Й┴Р▌Й╚Ц┌В╠ОцВшИ╡ВвЛyВ╤Р▌ТuВ╠ПЁМПВ╞ОшНHЙ╚Й┴Р▌НZВ╠СЭМ╕В╔В═БCЛнВвК╓ШAРлВкМйВчВъБCУ┴В╔БuУyТnГmПюЛ╡БvВ╔ЙeЛ┐ВЁОєВпВщВ▒В╞ВкФ╗Ц╛В╡В╜БBБi2БjНВУЩПмКwНZВ╠Й┴Р▌Й╚Ц┌В╔К╓В╖ВщЦ@Ч▀Й№Р│В═БCЙ№Р│В╠В╚ВвРqПэПмКwНZВ╔ВрФgЛyВ╖ВщВ▒В╞ВкОжН┤В│ВъВ╜БBБi3БjЙ№СPВЁК·С╥В╡В─Ц@Ч▀Й№Р│В╡Х╢ХФСхРbВкМPЧ▀ВЁФнВ╡В─ВрБCХKВ╕В╡ВрЦ@Ч▀ВкЦ┌УIВ╞В╖ВщВцВдВ╔В═БCЛ│ИчМ╗ПъВтЛ│ИчКEВкФ╜ЙЮВ╡В╚ВвПъНЗВрВаВщВ▒В╞ВкЦ╛ВчВйВ╔В╚В┴В╜БB en-copyright= kn-copyright= en-aut-name=TAKAHASHIToshiyuki en-aut-sei=TAKAHASHI en-aut-mei=Toshiyuki kn-aut-name=√№Л┤ХqФV kn-aut-sei=√№Л┤ kn-aut-mei=ХqФV aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=ЙкОRСхКwКwПpМдЛЖЙ@Л│ИчКwИц en-keyword=ОшНHЙ╚ kn-keyword=ОшНHЙ╚ en-keyword=Й┴Р▌Й╚Ц┌ kn-keyword=Й┴Р▌Й╚Ц┌ en-keyword=РqПэПмКwНZ kn-keyword=РqПэПмКwНZ en-keyword=НВУЩПмКwНZ kn-keyword=НВУЩПмКwНZ en-keyword=У·Ц{ТщНСХ╢ХФП╚ФNХё kn-keyword=У·Ц{ТщНСХ╢ХФП╚ФNХё END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=9 article-no= start-page=1756 end-page=1764 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthetic strategies for the construction of C3?N1БМ bisindoles en-subtitle= kn-subtitle= en-abstract= kn-abstract=C3?N1БМ bisindoles are unique structures, and the construction of these structures has drawn much attention. However, their synthesis still presents significant challenges that limit the functional group compatibility. This minireview summarizes the recent progress in the methodology for constructing C3?N1БМ bisindoles. There are two approaches for access to C3?N1БМ bisindoles: (1) direct approaches including reverse polarity techniques. (2) Stepwise approaches using designed and prefunctionalized substrates enable further functionalization by additional reactions to facilitate access to the target products. I believe that this review will allow its readers to develop novel approaches for the synthesis of C3?N1БМ bisindoles. en-copyright= kn-copyright= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=11 article-no= start-page=e202302963 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On Demand Synthesis of C3?N1Бf Bisindoles by a Formal Umpolung Strategy: First Total Synthesis of (Б})Б]Rivularin A en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this work, a straightforward synthesis of C3?N1Бf bisindolines is achieved by a formal umpolung strategy. The protocols were tolerant of a wide variety of substituents on the indole and indoline ring. In addition, the C3?N1Бf bisindolines could be converted to C3?N1Бf indole-indolines and C3?N1Бf-bisindoles. Also, we have successfully synthesized (Б})-rivularin A through a biomimetic late-stage tribromination as a key step. en-copyright= kn-copyright= en-aut-name=TokushigeKeisuke en-aut-sei=Tokushige en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=C3-N1' bisindoles kn-keyword=C3-N1' bisindoles en-keyword=bromination kn-keyword=bromination en-keyword=umpolung kn-keyword=umpolung en-keyword=rivularin A kn-keyword=rivularin A en-keyword=alkaloid kn-keyword=alkaloid END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=4 article-no= start-page=2772 end-page=2784 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Total Synthesis of the Proposed Structure of Indolyl 1,2-Propanediol Alkaloid, 1-(1H-Indol-3-yloxy)propan-2-ol en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first total synthesis of the proposed structure of unprecedented indolyl derivative bearing 1,2-propanediol moiety is described. Isomerization of 3-alkoxyindolines through indolenium intermediates was the key step in the total synthesis. H-1, C-13-NMR, IR, and HRMS spectra of the synthetic compound drastically differed to those of the originally reported structure, which suggests the natural product requires revision. en-copyright= kn-copyright= en-aut-name=KimataMomoko en-aut-sei=Kimata en-aut-mei=Momoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=1-(1H-indol-3-yloxy)propan-2-ol kn-keyword=1-(1H-indol-3-yloxy)propan-2-ol en-keyword=indole alkaloid kn-keyword=indole alkaloid en-keyword=isomerization kn-keyword=isomerization en-keyword=silver kn-keyword=silver en-keyword=umpolung kn-keyword=umpolung END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=4 article-no= start-page=e202301130 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Concise Synthesis of Thiazolo[4,5-b]indoles via Ring Switch/Cyclization Sequences en-subtitle= kn-subtitle= en-abstract= kn-abstract=The unexpected reactions of indoline hemiaminals affords 2,5-diaryl-4-hydroxythiazolines through a thioamidation/ring switch sequence. The key to success of this transformation is to use a thioamide as a thiazoline precursor under transient tautomeric control. This transformation features mild reaction conditions and good yields with broad functional group tolerance (17 examples, up to 99?% yield). Further transformations of the thiazolines provide a direct entry to dihydrothiazolo[4,5-b]indoles and thiazolo[4,5-b]indoles. en-copyright= kn-copyright= en-aut-name=YamadaKoji en-aut-sei=Yamada en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsubogoTetsu en-aut-sei=Tsubogo en-aut-mei=Tetsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanazawaHikaru en-aut-sei=Kanazawa en-aut-mei=Hikaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshizukaSayaka en-aut-sei=Ishizuka en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OhyamaKoutaro en-aut-sei=Ohyama en-aut-mei=Koutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KaidaMasaki en-aut-sei=Kaida en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=2 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=3 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=4 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=5 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=6 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=7 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=hemiaminals kn-keyword=hemiaminals en-keyword=indoles kn-keyword=indoles en-keyword=ring-switch kn-keyword=ring-switch en-keyword=thiazolo[4.5-b]indoles kn-keyword=thiazolo[4.5-b]indoles en-keyword=thioamides kn-keyword=thioamides END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=2023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem cells that show therapeutic effects on motor function in ALS mouse models. We conducted a single-center open phase II clinical trial to evaluate the safety and clinical effects of repeated intravenous injections of an allogenic Muse cell-based product, CL2020, in patients with ALS. Five patients with ALS received CL2020 intravenously once a month for a total of six doses. The primary endpoints were safety and tolerability, and the secondary endpoint was the rate of change in the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) score. In addition, serum tumor necrosis factor-Г┐ (TNF-Г┐), interleukin-6 (IL-6), sphingosine-1-phosphate (S1P), cerebrospinal fluid chitotriosidase-1 (CHIT-1), and neurofilament light chain (NfL) levels were evaluated. The CL2020 treatment was highly tolerated without serious side effects. The ALSFRS-R score change trended upward at 12 months post-CL2020 treatment compared with that at 3 months pre-administration, but the difference was not statistically significant. Among five patients diagnosed with ALS, three exhibited a decrease in the rate of ALSFRS-R score change, one demonstrated an increase, and another showed no change. In addition, the patientsБf serum IL-6 and TNF-Г┐ levels and cerebrospinal fluid CHIT-1 and NfL levels increased for up to 6 months post-treatment; however, their serum S1P levels continuously decreased over 12 months. These findings indicate a favorable safety profile of CL2020 therapy. In the near future, a double-blind study of a larger number of ALS patients should be conducted to confirm the efficacy of ALS treatment with CL2020. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TairaYuki en-aut-sei=Taira en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsuokaChika en-aut-sei=Matsuoka en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=amyotrophic lateral sclerosis kn-keyword=amyotrophic lateral sclerosis en-keyword=clinical trial kn-keyword=clinical trial en-keyword=CL2020 kn-keyword=CL2020 en-keyword=multilineage-differentiating stress-enduring (Muse) cells kn-keyword=multilineage-differentiating stress-enduring (Muse) cells en-keyword=intravenous administration kn-keyword=intravenous administration END start-ver=1.4 cd-journal=joma no-vol=183 cd-vols= no-issue= article-no= start-page=15 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Actual Situation of Handicraft Education Seen in the Ehime Education Association Magazine in the Dawn Era of Constructing the Basis of Handicraft Education (Second Part): History of Handicraft Education in Ehime (ЗW) kn-title=ОшНHЛ│ИчКюСbМЪР▌В╠ПММїОЮСуВ╔ВиВпВщИдХQЛ│ИчЛжЙяЛ@К╓ОПВ╔ МйВчВъВщОшНHЛ│ИчВ╠О└С╘БiМуХ╥Бj Б\ ИдХQМзОшНHЛ│ИчОjБiСцОlХёБj Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Б@Ц{Ш_В═БCИвХФО╡М▄ОOЛgБi1936БjВ╔ВцВщБuОшНHЛ│ИчКюСbМЪР▌В╠ПММїОЮСуБvБm1907БiЦ╛Об40 ФNБjНаБ` 1926БiСхР│15БjФNНаВ▄В┼БnВ╔ВиВпВщБC1911БiЦ╛Об44БjФNВ╠БuЙ№Р│ПмКwНZЧ▀БvВйВч1926БiСхР│15БjФNВ╠БuЙ№Р│ПмКwНZЧ▀БvВ▄В┼В╠14 ФNВXВйМОК╘ВЁТ▓Н╕С╬П█К·К╘В╞В╡В─БCИдХQЛ│ИчЛжЙяЛ@К╓ОПВ╔МйВчВъВщОшНHЛ│ИчК╓МWОjЧ┐ВЁТ▓Н╕В╡БCИдХQМзВ╠РqПэПмКwНZЛyВ╤НВУЩПмКwНZВ╔ВиВпВщОшНHЙ╚В╠РмЧзЛyВ╤УWКJЙ▀ТЎВЁТTВ┴В╜БBВ╗В╠МЛЙ╩БC1911БiЦ╛Об44БjФNВ╠БuЙ№Р│ПмКwНZЧ▀БvВ╔ВцВ┴В─ОшНHЙ╚В═БCНВУЩПмКwНZО└Л╞Й╚Ц┌В╠СIСЁХKПCЙ╚Ц┌В╠ИъВ┬В╞В╚В┴В╜ВкБCО└Л╞Й╚Ц┌В╞В╡В─В╠РлКiВкЛнВнВ╚ВщВ╞УпОЮВ╔БCОЎЛ╞ОЮРФВ╠СЭЙ┴ВкПмКwНZВ╔В╞В┴В─ХЙТSВ╔В╚ВшБCОшНHЙ╚Й┴Р▌НZВ═МЛЙ╩УIВ╔М╕ПнВ╡БCИдХQМзВ╠ПмКwНZВ╔ВиВпВщОшНHЛ│ИчВ═НмЦ└В╡В╜БB en-copyright= kn-copyright= en-aut-name=TAKAHASHIToshiyuki en-aut-sei=TAKAHASHI en-aut-mei=Toshiyuki kn-aut-name=√№Л┤ХqФV kn-aut-sei=√№Л┤ kn-aut-mei=ХqФV aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=ЙкОRСхКwКwПpМдЛЖЙ@Л│ИчКwИц en-keyword=ОшНHЙ╚ kn-keyword=ОшНHЙ╚ en-keyword=ОшНHЛ│Ич kn-keyword=ОшНHЛ│Ич en-keyword=РqПэПмКwНZ kn-keyword=РqПэПмКwНZ en-keyword=НВУЩПмКwНZ kn-keyword=НВУЩПмКwНZ en-keyword=ИдХQЛ│ИчЛжЙяЛ@К╓ОП kn-keyword=ИдХQЛ│ИчЛжЙяЛ@К╓ОП END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=14 article-no= start-page=9920 end-page=9926 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230711 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Oxytrofalcatin Puzzle: Total Synthesis and Structural Revision of Oxytrofalcatins B and C en-subtitle= kn-subtitle= en-abstract= kn-abstract=The previously reported structures of oxytrofalcatins B and C possess a benzoyl indole core. However, following synthesis and NMR comparison of both the proposed structure and the synthesized oxazole, we have revised the structure of oxytrofalcatins B and C as oxazoles. The synthetic route developed herein can further our understanding of the biosynthetic pathways that govern the production of natural 2,5-diaryloxazoles. en-copyright= kn-copyright= en-aut-name=SugitateKazuma en-aut-sei=Sugitate en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiIbuki en-aut-sei=Takahashi en-aut-mei=Ibuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaKoji en-aut-sei=Yamada en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-tobetsu, Hokkaido 0610293, Japan kn-affil= affil-num=4 en-affil=Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=447 cd-vols= no-issue= article-no= start-page=120608 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Neuroprotective effects of carnosine in a mice stroke model concerning oxidative stress and inflammatory response en-subtitle= kn-subtitle= en-abstract= kn-abstract=Carnosine (Г└-alanyl-L-histidine) is a natural dipeptide with multiple neuroprotective properties. Previous studies have advertised that carnosine scavenges free radicals and displays anti-inflammatory activity. However, the underlying mechanism and the efficacies of its pleiotropic effect on prevention remained obscure. In this study, we aimed to investigate the anti-oxidative, anti-inflammative, and anti-pyroptotic effects of carnosine in the transient middle cerebral artery occlusion (tMCAO) mouse model. After a daily pre-treatment of saline or carnosine (1000 mg / kg / day) for 14 days, mice (n = 24) were subjected to tMCAO for 60 min and continuously treated with saline or carnosine for additional 1 and 5 days after reperfusion. The administration of carnosine significantly decreased infarct volume 5 days after the tMCAO (*p < 0.05) and effectively suppressed the expression of 4-HNE, 8-OHdG, Nitrotyrosine 5 days, and RAGE 5 days after tMCAO. Moreover, the expression of IL-1Г└ was also significantly suppressed 5 days after tMCAO. Our present findings demonstrated that carnosine effectively relieves oxidative stress caused by ischemic stroke and significantly attenuates neuroinflammatory responses related to IL-1Г└, suggesting that carnosine can be a promising therapeutic strategy for ischemic stroke. en-copyright= kn-copyright= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=BianZhihong en-aut-sei=Bian en-aut-mei=Zhihong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YuHaibo en-aut-sei=Yu en-aut-mei=Haibo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HuXiao en-aut-sei=Hu en-aut-mei=Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=BianYuting en-aut-sei=Bian en-aut-mei=Yuting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SunHongming en-aut-sei=Sun en-aut-mei=Hongming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ischemic stroke kn-keyword=Ischemic stroke en-keyword=Carnosine kn-keyword=Carnosine en-keyword=Middle cerebral artery occlusion kn-keyword=Middle cerebral artery occlusion en-keyword=Oxidative stress kn-keyword=Oxidative stress en-keyword=Inflammation kn-keyword=Inflammation en-keyword=Pyroptosis kn-keyword=Pyroptosis END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=3 article-no= start-page=e36104 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Case of Drug-Resistant Myoclonus Improved by Only Slight Adjustment to the Hemodialysis Setting en-subtitle= kn-subtitle= en-abstract= kn-abstract=Myoclonus, a rare complication in patients with end-stage renal disease, is typically ameliorated through hemodialysis. The present case concerns an 84-year-old male with chronic renal failure undergoing hemodialysis, presenting involuntary movements in his limbs, which gradually worsened from the initiation of hemodialysis without constant elevation of serum blood urea nitrogen and electrolytes levels. Surface electromyography revealed characteristic findings consistent with myoclonus. He was diagnosed with subcortical-nonsegmental myoclonus related to hemodialysis, and the myoclonus was significantly alleviated after slightly increasing the post-dialysis target weight even though drug treatment was ineffective. This case suggests that drug-resistant myoclonus in patients with renal failure may be improved by adjusting hemodialysis settings, even in cases of atypical dialysis disequilibrium syndrome. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuokaChika en-aut-sei=Matsuoka en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KinomuraMasaru en-aut-sei=Kinomura en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, National Center of Neurology and Psychiatry kn-affil= en-keyword=dialysis disequilibrium syndrome kn-keyword=dialysis disequilibrium syndrome en-keyword=involuntary movement kn-keyword=involuntary movement en-keyword=renal failure kn-keyword=renal failure en-keyword=myoclonus kn-keyword=myoclonus en-keyword=hemodialysis kn-keyword=hemodialysis END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=3 article-no= start-page=365 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Actual Telemedicine Needs of Japanese Patients with Neurological Disorders in the COVID-19 Pandemic en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective During the coronavirus disease 2019 (COVID-19) pandemic, many social activities have moved online using applications for digital devices (e.g. computers, smartphones). We investigated the needs of telemedicine and trends in medical status and social care situations of Japanese patients with neurological disorders in order to estimate their affinity for an online telemedicine application. Methods We designed an original questionnaire for the present study that asked participants what problems they had with hospital visits, how the COVID-19 pandemic had affected their lives, and whether or not they would like to receive telemedicine.Patients The present study included volunteer caregivers, participants with Parkinson's disease (PD), epiamyotrophic lateral sclerosis (ALS), headache, myopathy, and other neurological diseases from Okayama University Hospital. Results A total of 29.6% of patients wanted to use telemedicine. Patients with ultheadaches (60.0%) and epilepsy (38.1%) were more likely to want to use telemedicine than patients with PD (17.8%) or stroke (19.0%). Almost 90% of patients had access to a digital device, and there was no association between favoring telemedicine, ownership of a digital device, hospital visiting time, or waiting time at the hospital, although age was associated with motivation to telemedicine use (52.6 vs. 62.2 years old, p < 0.001). Conclusion We can contribute to the management of the COVID-19 pandemic and the medical economy by promoting telemedicine, especially for young patients with headaches or epilepsy. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=telemedicine kn-keyword=telemedicine en-keyword=neurological disorder kn-keyword=neurological disorder en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=headache kn-keyword=headache en-keyword=epilepsy kn-keyword=epilepsy END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=5 article-no= start-page=4411 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives en-subtitle= kn-subtitle= en-abstract= kn-abstract=NK-4 plays a key role in the treatment of various diseases, such as in hay fever to expect anti-allergic effects, in bacterial infections and gum abscesses to expect anti-inflammatory effects, in scratches, cuts, and mouth sores from bites inside the mouth for enhanced wound healing, in herpes simplex virus (HSV)-1 infections for antiviral effects, and in peripheral nerve disease that causes tingling pain and numbness in hands and feet, while NK-4 is used also to expect antioxidative and neuroprotective effects. We review all therapeutic directions for the cyanine dye NK-4, as well as the pharmacological mechanism of NK-4 in animal models of related diseases. Currently, NK-4, which is sold as an over-the-counter drug in drugstores, is approved for treating allergic diseases, loss of appetite, sleepiness, anemia, peripheral neuropathy, acute suppurative diseases, wounds, heat injuries, frostbite, and tinea pedis in Japan. The therapeutic effects of NK-4Бfs antioxidant and neuroprotective properties in animal models are now under development, and we hope to apply these pharmacological effects of NK-4 to the treatment of more diseases. All experimental data suggest that different kinds of utility of NK-4 in the treatment of diseases can be developed based on the various pharmacological properties of NK-4. It is expected that NK-4 could be developed in more therapeutic strategies to treat many types of diseases, such as neurodegenerative and retinal degenerative diseases. en-copyright= kn-copyright= en-aut-name=LiuShihui en-aut-sei=Liu en-aut-mei=Shihui kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=8 article-no= start-page=2122 end-page=2125 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220817 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=First Total Synthesis of Reassigned Echinosulfonic Acid D en-subtitle= kn-subtitle= en-abstract= kn-abstract=Echinosulfonic acid D, a sponge metabolite whose structure was recently reassigned, was synthesized for the first time. The key step is the double indolization of dimethylbarbituric acid using the umpolung indole reagent, followed by a hydrolysis/decarboxylation/esterification sequence. en-copyright= kn-copyright= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakajimaRen en-aut-sei=Nakajima en-aut-mei=Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SawadaDaisuke en-aut-sei=Sawada en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=5 article-no= start-page=255 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220615 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be considered for surgical resection as treatment. Herein, we report a Japanese patient with a CCM2 mutation, c.609G>A (p.K203K) substitution, who showed drug-resistant epilepsy and dramatic improvement after surgical resection. en-copyright= kn-copyright= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SasakiTatsuya en-aut-sei=Sasaki en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AkagawaHiroyuki en-aut-sei=Akagawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Tokyo Women's Medical University Institute for Integrated Medical Sciences kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University kn-affil= en-keyword=CCM2 kn-keyword=CCM2 en-keyword=cerebral cavernous malformation kn-keyword=cerebral cavernous malformation en-keyword=drug-resistant epilepsy kn-keyword=drug-resistant epilepsy END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ГgГВГVГУГZГVГXВ╔ВцВщГCГКГUГНГtОоНЬЙДТ╖Г{ГЛГgСХТЕК│О╥В╔С╬В╖ВщОBЙeХ√Ц@В╞Н─Н\РмХ√Ц@В╠МЯУв kn-title=Evaluation of Patient Positioning During Digital Tomosynthesis and ReconstructionAlgorithms for Ilizarov Frames: A Phantom Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeYuki en-aut-sei=Abe en-aut-mei=Yuki kn-aut-name=ИвХФЧEЛP kn-aut-sei=ИвХФ kn-aut-mei=ЧEЛP aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@Х█МТКwМдЛЖЙ╚ END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=37 article-no= start-page=e202201113 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220519 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Indole Editing Enabled by HFIPБ]Mediated RingБ]Switch Reactions of 3Б]AminoБ]2Б]Hydroxyindolines en-subtitle= kn-subtitle= en-abstract= kn-abstract=We found the novel reactivity of hemiaminal as a precursor for indole editing at the multi-site. The HFIP-promoted indole editing of indoline hemiaminals affords 2-arylindoles through a ring-switch sequence. The key to success of this transformation is to use a cyclic hemiaminal as an a-amino aldehyde surrogate under transient tautomeric control. This transformation features mild reaction conditions and good yields with broad functional group tolerance. The utility of this transformation is presented through the one-pot protocol and the synthesis of isocryptolepine. en-copyright= kn-copyright= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimizuKaho en-aut-sei=Shimizu en-aut-mei=Kaho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SawadaDaisuke en-aut-sei=Sawada en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=hemiaminals kn-keyword=hemiaminals en-keyword=HFIP kn-keyword=HFIP en-keyword=indoles kn-keyword=indoles en-keyword=molecule editing kn-keyword=molecule editing en-keyword=ring-switch kn-keyword=ring-switch END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=1 article-no= start-page=111 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202238 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Protective Effect of Rivaroxaban Against Amyloid Pathology and Neuroinflammation Through Inhibiting PAR-1 and PAR-2 in AlzheimerБfs Disease Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Recent studies have revealed that atrial fibrillation (AF) patients have a high risk of developing cognitive impairment, vascular dementia, and AlzheimerБfs disease (AD). Some reports suggest that the application of oral anticoagulant with an appropriate dose may have a preventive effect on AD. However, which oral anticoagulant drug is more appropriate for preventing AD and the underlying mechanism(s) is still unknown. Objective: The aim of the present study was to assess the treatment effect of rivaroxaban administration as well as investigate the roles of PAR-1 and PAR-2 in the AD?+?CAA mice model. Methods: In the present study, we compared a traditional oral anticoagulant, warfarin, and a direct oral anticoagulant (DOAC), rivaroxaban, via long-term administration to an AD with cerebral amyloid angiopathy (CAA) mice model. Results: Rivaroxaban treatment attenuated neuroinflammation, blood-brain barrier dysfunction, memory deficits, and amyloid-Г└ deposition through PAR-1/PAR-2 inhibition in the AD?+?CAA mice model compared with warfarin and no-treatment groups. Conclusion: The present study demonstrates that rivaroxaban can attenuate AD progress and can be a potential choice to prevent AD. en-copyright= kn-copyright= en-aut-name=BianZhihong en-aut-sei=Bian en-aut-mei=Zhihong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YuHaibo en-aut-sei=Yu en-aut-mei=Haibo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HuXiao en-aut-sei=Hu en-aut-mei=Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BianYuting en-aut-sei=Bian en-aut-mei=Yuting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SunHongming en-aut-sei=Sun en-aut-mei=Hongming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=National Center Hospital, National Center of Neurology and Psychiatry kn-affil= affil-num=16 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=AlzheimerБfs disease kn-keyword=AlzheimerБfs disease en-keyword=cerebral amyloid angiopathy chronic cerebral hypoperfusion kn-keyword=cerebral amyloid angiopathy chronic cerebral hypoperfusion en-keyword=rivaroxaban kn-keyword=rivaroxaban en-keyword=warfarin kn-keyword=warfarin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Iimoriyama-higashi Mounded Tomb No. 1 -Survey of a mounded tomb with a small stone coffin kn-title=Ф╤Р╖ОRУМ1НЖХн Б|ХнЛuСкЧ╩Т▓Н╕БEР╬К╗ФнМ@Т▓Н╕ХёНРБ| en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ц{ПСВ═БAЙкОRОsЦkЛцЦFЙъ3082Ф╘1В╔ПКН▌В╖ВщФ╤Р╖ОRУМ1НЖХнВ╔ВиВвВ─БA2019ФN3МОВ╔НsВэВъВ╜ХнЛuСкЧ╩Т▓Н╕В╞Р╬К╗В╠ФнМ@Т▓Н╕ХёНРВ┼ВаВщБBЦ{М├ХнВ═О№ТmВ╠ЦДСаХ╢Й╗НрХяСаТnВ╞В╡В─УoШ^В│ВъВ─ВвВ╜ВкБAЦ╝П╠ВЁОЭВ╜В╚ВйВ┴В╜В╜В▀БAТ▓Н╕В╔УЦВ╜ВшЙкОRОsВ╞ЛжЛcВ╠ПуБAФ╤Р╖ОRУМ1НЖХнВ╠Ц╝П╠ВЁЧ^ВжВ╜БBЦ{Т▓Н╕В═БAЙкОRСхКwНlМ├КwМдЛЖО║ВкОхС╠В╞В╚ВшБAР┤Й╞П═БiЙкОRСхКwСхКwЙ@О╨ЙяХ╢Й╗Й╚КwМдЛЖЙ╚Л│ОЎБjВкТSУЦВ╡В─Т▓Н╕ВЁО└О{В╡В╜БB en-copyright= kn-copyright= en-aut-name=SeikeAkira en-aut-sei=Seike en-aut-mei=Akira kn-aut-name=Р┤Й╞П═ kn-aut-sei=Р┤Й╞ kn-aut-mei=П═ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Р┤ОRЧ▓ kn-aut-sei=Р┤ОR kn-aut-mei=Ч▓ aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФР╜Мх kn-aut-sei=ИвХФ kn-aut-mei=Р╜Мх aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ТЖРьХ№Ф№ kn-aut-sei=ТЖРь kn-aut-mei=Х№Ф№ aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=КzУcРчЙ─ kn-aut-sei=КzУc kn-aut-mei=РчЙ─ aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=НтЦ{Цл kn-aut-sei=НтЦ{ kn-aut-mei=Цл aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=СыПуХС kn-aut-sei=СыПу kn-aut-mei=ХС aut-affil-num=7 ORCID= affil-num=1 en-affil=The Department of Archaeology, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@О╨ЙяХ╢Й╗Й╚КwМдЛЖЙ╚НlМ├КwМдЛЖО║ affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil=НСЧзЧЁОjЦпСнФОХиК┘ affil-num=7 en-affil= kn-affil=НСЧзЙ╚КwФОХиК┘ END start-ver=1.4 cd-journal=joma no-vol=387 cd-vols= no-issue=15 article-no= start-page=70 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20184 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Familial and sporadic chronic progressive degenerative parietal ataxia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background & objective: Parietal ataxia has been mainly reported as a consequence of acute ischemic stroke, while degenerative parietal ataxia has not been reported. Methods: We investigated clinical characteristics, neuroimaging data, and genetic analysis of patients with cerebellar ataxia plus parietal atrophy. Results: We identified seven patients, including five patients from two families, with chronic progressive cerebellar ataxia due to degenerative parietal atrophy but not stroke. Age at onset of ataxia was 57.6 +/- 6.9 years. All patients showed chronic progressive cerebellar ataxia with severity of ataxic gait > limb ataxia > dysarthria. Patients showed no cognitive dysfunction, muscle weakness, or parkinsonism, and only two patients showed mild sensory disturbances. The seven patients showed lateralized limb ataxia with greater contralateral parietal lobe atrophy by magnetic resonance imaging, and hypoperfusion by single photon emission computed tomography, without any abnormal cerebellar pathology (i.e., crossed cerebellar diaschisis). Pathogenic mutations in the microtubule-associated protein tau gene were not found using two single nucleotide polymorphisms. Conclusions: This is the first description showing unique clinical features of familial and sporadic chronic progressive degenerative parietal ataxia. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkeuchiTakeshi en-aut-sei=Ikeuchi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KitaguchiMasataka en-aut-sei=Kitaguchi en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=5 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=6 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=9 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=10 en-affil=Department of Molecular Genetics, Bioresource Science Branch, Center of Bioresource, Brain Research Institute Niigata University kn-affil= affil-num=11 en-affil=Department of Neurology, Baba Memorial Hospital kn-affil= affil-num=12 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= en-keyword=parietal ataxia kn-keyword=parietal ataxia en-keyword=parietal lobe atrophy kn-keyword=parietal lobe atrophy en-keyword=crossed cerebellar diaschisis kn-keyword=crossed cerebellar diaschisis en-keyword=MAPT kn-keyword=MAPT END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=9 article-no= start-page=1818 end-page=1828 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Downregulation of PAR-1 and PAR-2 by Rivaroxaban kn-title=Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to assess the risk of intracerebral hemorrhage (ICH) after tissue-type plasminogen activator (tPA) treatment in rivaroxaban compared with warfarin-pretreated male Wistar rat brain after ischemia in relation to activation profiles of protease-activated receptor-1, -2, -3, and -4 (PAR-1, -2, -3, and -4). After pretreatment with warfarin (0.2?mg/kg/day), low-dose rivaroxaban (60?mg/kg/day), high-dose rivaroxaban (120?mg/kg/day), or vehicle for 14 days, transient middle cerebral artery occlusion was induced for 90?min, followed by reperfusion with tPA (10?mg/kg/10?ml). Infarct volume, hemorrhagic volume, immunoglobulin G leakage, and blood parameters were examined. Twenty-four hours after reperfusion, immunohistochemistry for PARs was performed in brain sections. ICH volume was increased in the warfarin-pretreated group compared with the rivaroxaban-treated group. PAR-1, -2, -3, and -4 were widely expressed in the normal brain, and their levels were increased in the ischemic brain, especially in the peri-ischemic lesion. Warfarin pretreatment enhanced the expression of PAR-1 and PAR-2 in the peri-ischemic lesion, whereas rivaroxaban pretreatment did not. The present study shows a lower risk of brain hemorrhage in rivaroxaban-pretreated compared with warfarin-pretreated rats following tPA administration to the ischemic brain. It is suggested that the relative downregulation of PAR-1 and PAR-2 by rivaroxaban compared with warfarin pretreatment might be partly involved in the mechanism of reduced hemorrhagic complications in patients receiving rivaroxaban in clinical trials. ? 2016 Wiley Periodicals, Inc. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonoSyoichiro en-aut-sei=Kono en-aut-mei=Syoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HeitmeierStefan en-aut-sei=Heitmeier en-aut-mei=Stefan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=PerzbornElisabeth en-aut-sei=Perzborn en-aut-mei=Elisabeth kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=5 en-affil=Departments of Neurology kn-affil= affil-num=6 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=9 en-affil=Bayer Pharma AG, Drug Discovery - Global Therapeutic Research Groups, Cardiovascular Pharmacology kn-affil= affil-num=10 en-affil=Bayer Pharma AG, Drug Discovery - Global Therapeutic Research Groups, Cardiovascular Pharmacology kn-affil= affil-num=11 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= en-keyword=PAR-3 kn-keyword=PAR-3 en-keyword=PAR-4 kn-keyword=PAR-4 en-keyword=tissue plasminogen activator kn-keyword=tissue plasminogen activator en-keyword=warfarin kn-keyword=warfarin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models en-subtitle= kn-subtitle= en-abstract= kn-abstract= The feasibility of transcranial sonothrombolysis has been demonstrated, although little is known about the relationships between thermal or mechanical mechanisms and thrombolytic outcomes. Therefore, the present study aims to reveal the effect and safety of temperature and ultrasound through in vitro and in vivo thrombolysis models. Artificial clots in microtubes were heated in a water bath or sonicated by ultrasound irradiation, and then clots weight decrease with rising temperature and sonication time was confirmed. In the in vitro thrombotic occlusion model, based on spot heating, clot volume was reduced and clots moved to the distal side, followed by recanalization of the occlusion. In the in vivo study, the common carotid artery of rats was exposed to a spot heater or to sonication. No brain infarct or brain blood barrier disruption was shown, but endothelial junctional dysintegrity and an inflammatory response in the carotid artery were detected. The present spot heating and ultrasound irradiation models seem to be effective for disintegrating clots in vitro, but the safety of the in vivo model was not fully supported by the data. However, the data indicates that a shorter time exposure could be less invasive than a longer exposure. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=17 article-no= start-page=2343 end-page=2346 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Delayed Aortic Surgery for a Patient with Ischemic Stroke Secondary to Aortic Dissection en-subtitle= kn-subtitle= en-abstract= kn-abstract=The diagnosis of aortic dissection (AD) is sometimes difficult within the limited time window of recombinant tissue plasminogen activator (tPA) for ischemic stroke (IS). A 60-year-old man developed sudden left hemiparesis due to IS. During tPA infusion, his blood pressure dropped and consciousness declined. After transfer to our hospital, carotid duplex ultrasonography led to a diagnosis of AD. Emergency surgery was postponed because of the risk of hemorrhagic transformation. The patient successfully underwent aortic surgery on day 5 and was discharged with a remarkable improvement in his symptoms. Delayed surgery may avoid hemorrhagic transformation in patients with AD-induced IS who have received tPA. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ManabeYasuhiro en-aut-sei=Manabe en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KonoSyoichiro en-aut-sei=Kono en-aut-mei=Syoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=9 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=11 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=12 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=13 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=7 article-no= start-page=1897 end-page=1903 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=2022 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of 2-monosubstituted indolin-3-ones by cine-substitution of 3-azido-2-methoxyindolines en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a formal cine-substitution/hydrolysis of 3-azidoindoles generated from 3-azido-2-methoxyindolines (AZINs). This protocol enables the introduction of various carboxylic acids and alcohols into indolin-3-ones at the C2-position, affording 2-monoacyloxy or alkoxy indolin-3-ones. en-copyright= kn-copyright= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SawadaDaisuke en-aut-sei=Sawada en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page=98 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mutations in the ATP-binding cassette subfamily C member 6 (ABCC6) gene are responsible for pseudoxanthoma elasticum (PXE). PXE is a rare genetic metabolic disease with autosomal recessive inheritance that shows ectopic mineralization in skin, eyes and blood vessels, and causes cerebrovascular disease. There are few reports of intracranial hemorrhages in patients with the ABCC6 mutation. We report the first Japanese case with a heterozygous ABCC6 mutation displaying recurrent ischemic strokes and intracranial hemorrhages. We propose that the ABCC6 mutation may be one cause of neurovascular diseases with a family history. en-copyright= kn-copyright= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IkegamiKen en-aut-sei=Ikegami en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=UemuraMasahiro en-aut-sei=Uemura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Brain Research Institute, Niigata University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ATP-binding cassette subfamily C member 6 (ABCC6) kn-keyword=ATP-binding cassette subfamily C member 6 (ABCC6) en-keyword=neurovascular diseases kn-keyword=neurovascular diseases en-keyword=pseudoxanthoma elasticum (PXE) kn-keyword=pseudoxanthoma elasticum (PXE) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=13381 end-page=13384 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=cis-3-Azido-2-methoxyindolines as safe and stable precursors to overcome the instability of fleeting 3-azidoindoles en-subtitle= kn-subtitle= en-abstract= kn-abstract=Use of 3-azidoindoles in organic synthesis remains a difficult task owing to their instabilities. Herein, we report a general and concise approach for tackling this problem by using 3-azidoindole surrogates. The surrogates are bench-stable, presumably due to the observed intramolecular O-N-beta bonding. The resultant fleeting intermediates undergo capturing in situ to afford 3-substitued indoles through formal ipso-substitution of the azide group by nucleophiles. In these investigations, we found that the fleeting 3-azidoindoles show a C3-electrophilic character for the first time. en-copyright= kn-copyright= en-aut-name=YamashiroToshiki en-aut-sei=Yamashiro en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniokaMasaru en-aut-sei=Tanioka en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KaminoShinichiro en-aut-sei=Kamino en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SawadaDaisuke en-aut-sei=Sawada en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=School of Pharmaceutical Sciences, Aichi Gakuin University kn-affil= affil-num=4 en-affil=School of Pharmaceutical Sciences, Aichi Gakuin University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=19 article-no= start-page=3155 end-page=3160 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (I-123-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients. en-copyright= kn-copyright= en-aut-name=KitamuraWataru en-aut-sei=Kitamura en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YukawaRyoya en-aut-sei=Yukawa en-aut-mei=Ryoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshidaChikamasa en-aut-sei=Yoshida en-aut-mei=Chikamasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakasukaHiroki en-aut-sei=Takasuka en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiiKeiko en-aut-sei=Fujii en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MatsuokaKen-Ichi en-aut-sei=Matsuoka en-aut-mei=Ken-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Hematology, Okayama City Hospital kn-affil= affil-num=6 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Division of Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=11 en-affil=Division of Blood Transfusion, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Neurology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= en-keyword=peripheral T-cell lymphoma kn-keyword=peripheral T-cell lymphoma en-keyword=chorea kn-keyword=chorea en-keyword=single photon-emission computed tomography kn-keyword=single photon-emission computed tomography END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=13 article-no= start-page=2125 end-page=2128 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case. en-copyright= kn-copyright= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkegamiKen en-aut-sei=Ikegami en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamashitaTom en-aut-sei=Yamashita en-aut-mei=Tom kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TaniguchiKohei en-aut-sei=Taniguchi en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Departments of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Departments of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=encephalopathy kn-keyword=encephalopathy en-keyword=IgG4 related disease kn-keyword=IgG4 related disease en-keyword=interleukin-6 kn-keyword=interleukin-6 en-keyword=multicentric Castleman's disease kn-keyword=multicentric Castleman's disease END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=21 article-no= start-page=3163 end-page=3165 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction en-subtitle= kn-subtitle= en-abstract= kn-abstract=A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, The University of Tokyo Hospital kn-affil= affil-num=11 en-affil=Department of Molecular Neurology, The University of Tokyo Hospital, Japan Institute of Medical Genomics, International University of Health and Welfare kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=spastic paraplegia kn-keyword=spastic paraplegia en-keyword=extrapyramidal sign kn-keyword=extrapyramidal sign en-keyword=frontal cognitive dysfunction kn-keyword=frontal cognitive dysfunction END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=7 article-no= start-page=1033 end-page=1036 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C en-subtitle= kn-subtitle= en-abstract= kn-abstract=Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN gene (WRN). Most Japanese WS patients are born from a consanguineous marriage with homozygous WRN mutations. We herein report a rare WS patient born from non-consanguineous parents with compound heterozygous WRN mutations with a novel heterogeneous c.1720+1G>A substitution plus the most frequent heterogeneous c.3139-1G>C substitution among Japanese. Although the present case showed clinical characteristics common to previous Japanese WS patients, he had not developed any malignant tumors as of 43 years of age, suggesting that WS patients with this particular genetic mutation have a different phenotype than others. en-copyright= kn-copyright= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeAki en-aut-sei=Watanabe en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YokoteKoutaro en-aut-sei=Yokote en-aut-mei=Koutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakemotoMinoru en-aut-sei=Takemoto en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OshimaJunko en-aut-sei=Oshima en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama Citizen's Hospital kn-affil= affil-num=4 en-affil=Department of General Internal Medicine, Okayama Citizen's Hospital kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University kn-affil= affil-num=11 en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University kn-affil= affil-num=12 en-affil=Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare kn-affil= affil-num=13 en-affil=Department of Pathology, University of Washington kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=werner syndrome kn-keyword=werner syndrome en-keyword=compound heterozygous kn-keyword=compound heterozygous en-keyword=Japanese kn-keyword=Japanese END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=3 article-no= start-page=437 end-page=440 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Klinefelter syndrome is a chromosomal disorder with a typical karyotype of 47, XXY, accompanied by various neurological symptoms. We herein report the first case of Klinefelter syndrome with a rare mosaic form of 47, XXY and 48, XXXY, combined with both spastic paraplegia and peripheral motor neuropathy. This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities. A motor nerve conduction study and the magnetic motor evoked potential suggested motor axonal neuropathy and corticospinal tract disorders. The present case suggests that Klinefelter syndrome can present with both upper and lower motor neuron degeneration. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Klinefelter syndrome kn-keyword=Klinefelter syndrome en-keyword=mosaic form kn-keyword=mosaic form en-keyword=peripheral neuropathy kn-keyword=peripheral neuropathy en-keyword=spastic paraplegia kn-keyword=spastic paraplegia END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=8 article-no= start-page=1081 end-page=1085 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective We evaluated the clinical effects of a telephone call service for psychological symptoms such as anxiety, depression or apathy in subacute myelo-optico-neuropathy (SMON) patients living alone or with a single caregiver.
Methods Up to 16 SMON patients (4 men, 12 women) and 32 control subjects were evaluated by the geriatric depression scale (GDS), apathy scale (AS) and state and trait anxiety inventory (STAI) forms X-I, including the P and A values for depression, apathy and state anxiety including disturbed peace of mind and enhanced anxiety, respectively, before (pre) and three months after (post) the telephone call service.
Results The SMON patients, especially women, had significantly worse baseline scores in GDS (depression), AS (apathy) and STAI (state anxiety) than control subjects. The automated telephone call service significantly improved the high baseline STAI scores, including the P and A scores (disturbed peace of mind and enhanced anxiety), of SMON patients but not the GDS or AS scores.
Conclusion SMON patients, especially women, living alone or with a single caregiver showed higher baseline depression, apathy and anxiety scores than the control subjects. The present automated telephone call service proved to be a useful care tool for improving the anxiety of SMON patients with high STAI P and A scores. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DoutareShinji en-aut-sei=Doutare en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Doutare Medical Clinic kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=anxiety kn-keyword=anxiety en-keyword=SMON kn-keyword=SMON en-keyword=STAI kn-keyword=STAI en-keyword=telephone call service kn-keyword=telephone call service END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=2 article-no= start-page=305 end-page=308 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years After the First Instance of Optic Neuritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Combined central and peripheral demyelination (CCPD) causes demyelination in both the central and peripheral nervous systems. Anti-neurofascin 155 antibody plays an important pathogenic role in CCPD, but evidence concerning an association between this antibody and CCPD remains inconclusive. Although there have been no reports of precedent optic neuritis developing into CCPD, we herein report a Japanese man in whom optic neuritis recurred four times over nine years and who developed CCPD without positive antineurofascin 155 antibody. This case suggests the possibility of developing CCPD after optic nerve neuritis and the existence of an unknown antibody that induces CCPD. en-copyright= kn-copyright= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OgataHidenori en-aut-sei=Ogata en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Combined central and peripheral demyclination (CCPD) kn-keyword=Combined central and peripheral demyclination (CCPD) en-keyword=recurrent optic neuritis kn-keyword=recurrent optic neuritis END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=19 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Growing evidence indicates that reduced uterine perfusion pressure (RUPP) triggers the cascade of events leading to preeclampsia. Edaravone is a powerful free radical scavenger used for the treatment of ischemia/reperfusion diseases due to its anti-oxidative stress and anti-inflammatory properties. Here we investigate the effect of edaravone (3 mg/kg) on different maternal and fetal outcomes of RUPP-induced placental ischemia mice model. RUPP surgery was performed on gestation day (GD) 13 followed by edaravone injection from GD14 to GD18, sacrifice day. The results showed that edaravone injection significantly decreased the maternal blood pressure (113.2 +/- 2.3 mmHg) compared with RUPP group (131.5 +/- 1.9 mmHg). Edaravone increased fetal survival rate (75.4%) compared with RUPP group (54.4%), increased fetal length, weights, and feto-placental ratio (7.2 and 5.7 for RUPP and RUPP-Edaravone groups, respectively) compared with RUPP group. In addition, RUPP resulted in many fetal morphological abnormalities as well as severe delayed ossification, however edaravone decreased the morphological abnormalities and increased the ossification of the fetal endoskeleton. Edaravone improved the histopathological structure of the maternal kidney and heart as well as decreased the elevated blood urea and creatinine levels (31.5 +/- 0.15 mg/dl (RUPP), 25.6 +/- 0.1 mg/dl (RUPP+edaravone) for urea and 5.4 +/- 0.1 mg/dl (RUPP), 3.5 +/- 0.1 mg/dl (RUPP+edaravone) for creatinine) and decreased cleaved caspase-3 expression in the maternal kidney. In conclusion, this study demonstrated that our RUPP mice model recapitulated preeclampsia symptoms and edaravone injection ameliorated most of these abnormalities suggesting its effectiveness and potential application in preeclampsia treatment regimes. en-copyright= kn-copyright= en-aut-name=AtallahMarwa en-aut-sei=Atallah en-aut-mei=Marwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Preeclampsia kn-keyword=Preeclampsia en-keyword=RUPP kn-keyword=RUPP en-keyword=Edaravone kn-keyword=Edaravone en-keyword=Placental ischemia kn-keyword=Placental ischemia en-keyword=Endoskeleton kn-keyword=Endoskeleton en-keyword=Fetal growth restriction kn-keyword=Fetal growth restriction END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue= article-no= start-page=35 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Model architectures to extrapolate emotional expressions in DNN-based text-to-speech en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes architectures that facilitate the extrapolation of emotional expressions in deep neural network (DNN)-based text-to-speech (TTS). In this study, the meaning of Бgextrapolate emotional expressionsБh is to borrow emotional expressions from others, and the collection of emotional speech uttered by target speakers is unnecessary. Although a DNN has potential power to construct DNN-based TTS with emotional expressions and some DNN-based TTS systems have demonstrated satisfactory performances in the expression of the diversity of human speech, it is necessary and troublesome to collect emotional speech uttered by target speakers. To solve this issue, we propose architectures to separately train the speaker feature and the emotional feature and to synthesize speech with any combined quality of speakers and emotions. The architectures are parallel model (PM), serial model (SM), auxiliary input model (AIM), and hybrid models (PM&AIM and SM&AIM). These models are trained through emotional speech uttered by few speakers and neutral speech uttered by many speakers. Objective evaluations demonstrate that the performances in the open-emotion test provide insufficient information. They make a comparison with those in the closed-emotion test, but each speaker has their own manner of expressing emotion. However, subjective evaluation results indicate that the proposed models could convey emotional information to some extent. Notably, the PM can correctly convey sad and joyful emotions at a rate of >60%. en-copyright= kn-copyright= en-aut-name=InoueKatsuki en-aut-sei=Inoue en-aut-mei=Katsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HaraSunao en-aut-sei=Hara en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HojoNobukatsu en-aut-sei=Hojo en-aut-mei=Nobukatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IjimaYusuke en-aut-sei=Ijima en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate school of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Graduate school of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Graduate school of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=NTT Corporation kn-affil= affil-num=5 en-affil=NTT Corporation kn-affil= en-keyword=Emotional speech synthesis kn-keyword=Emotional speech synthesis en-keyword=Extrapolation kn-keyword=Extrapolation en-keyword=DNN-based TTS kn-keyword=DNN-based TTS en-keyword=Text-to-speech kn-keyword=Text-to-speech en-keyword=Acoustic model kn-keyword=Acoustic model en-keyword=Phoneme duration model kn-keyword=Phoneme duration model END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=166 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201214 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A new telestroke network system in northern area of Okayama prefecture en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Telestroke network can provide rapid access to specialized treatment and improves onБ]site management of acute stroke patients through the БghubБ]andБ]spokeБh model. In the northern part of Okayama Prefecture, there has been a regional gap of stroke care due to the shortage of stroke specialists and facilities. In addition, due to the novel coronavirus disease 2019 (COVIDБ]19), it is required to reduce the unnecessary contact with stroke patients from other hospitals.
Aim
We organized a novel costБ]free telestroke network with an image and video sharing for neurological diseases in the northern part of Okayama Prefecture to improve the stroke management in the area.
Method
We prepared the tablet device on which Skype? application was installed for each hospital and recruited the patients who visited or hospitalized in the spoke hospitals and were suspected to have some neurological diseases from April 2019 to May 2020. The patient's clinical data were recorded and analyzed.
Results
During the study period, 5 patients were recruited including the cases with the initial diagnosis of stroke or brain tumor. Among them, 2 cases were transferred to the hub hospital, 2 cases were transferred to other hospitals, and 1 case was treated on site under specialist's advice.
Conclusion
The new telestroke network system may be beneficial for acute stroke management and reducing the unnecessary patient's transfer in the rural area, especially under coexistence with COVIDБ]19. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiKazuki en-aut-sei=Kobayashi en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SawataTakashi en-aut-sei=Sawata en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatoYuki en-aut-sei=Sato en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KubotaJunichi en-aut-sei=Kubota en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MizobuchiMasayuki en-aut-sei=Mizobuchi en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HayashiTakashi en-aut-sei=Hayashi en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Tsuyama Central Hospital kn-affil= affil-num=7 en-affil=Department of Neurosurgery, Tsuyama Central Hospital kn-affil= affil-num=8 en-affil=Department of Gastrointestinal Surgery, Tsuyama 1st Hospital kn-affil= affil-num=9 en-affil=Department of Internal Medicine, Sato Memorial Hospital kn-affil= affil-num=10 en-affil=Department of Internal Medicine, Tajiri Hospital kn-affil= affil-num=11 en-affil=Department of Neurosurgery, Kaneda Hospital kn-affil= affil-num=12 en-affil=Department of Orthopedics, Sayo Central Hospital kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=COVIDБ]19 kn-keyword=COVIDБ]19 en-keyword=Okayama kn-keyword=Okayama en-keyword=skype kn-keyword=skype en-keyword=telemedicine kn-keyword=telemedicine en-keyword=telestroke kn-keyword=telestroke END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=217 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200107 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A New Serum Biomarker Set to Detect Mild Cognitive Impairment and AlzheimerБfs Disease by Peptidome Technology en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background:
Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing AlzheimerБfs disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid- Г└ (AГ└), plasma tau, and serum antibodies for AГ└1 - 42 are not yet well established.
Objective:
We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology.
Methods:
With only 1.5Г╩l of serum, we examined a new target plate БgBLOTCHIP?Бh plus a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n?=?100), MCI (n?=?60), and AD (n?=?99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains.
Results:
Apart from AГ└ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (***p? Conclusion:
The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage. en-copyright= kn-copyright= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IkedaMasaki en-aut-sei=Ikeda en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkamotoKoichi en-aut-sei=Okamoto en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=ShojiMikio en-aut-sei=Shoji en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TakatamaMasamitsu en-aut-sei=Takatama en-aut-mei=Masamitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KojoMotohisa en-aut-sei=Kojo en-aut-mei=Motohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KurodaTakeshi en-aut-sei=Kuroda en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OnoKenjiro en-aut-sei=Ono en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KimuraNoriyuki en-aut-sei=Kimura en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=MatsubaraEtsuro en-aut-sei=Matsubara en-aut-mei=Etsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=WakutaniYosuke en-aut-sei=Wakutani en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=TakaoYoshiki en-aut-sei=Takao en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=HigashiYasuto en-aut-sei=Higashi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=AsadaKyoichi en-aut-sei=Asada en-aut-mei=Kyoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=SengaTakehito en-aut-sei=Senga en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name= LeeLyang-Ja en-aut-sei= Lee en-aut-mei=Lyang-Ja kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=TanakaKenji en-aut-sei=Tanaka en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama City Hospital, Okayama kn-affil= affil-num=11 en-affil=Department of Neurology, Gunma University, Graduate School of Medicine kn-affil= affil-num=12 en-affil=Department of Neurology, Gunma University, Graduate School of Medicine kn-affil= affil-num=13 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=14 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=15 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=16 en-affil=Department of Neurology, Ako Chuo Hospital kn-affil= affil-num=17 en-affil=Division of Neurology, Department of Medicine, Showa University, School of Medicine kn-affil= affil-num=18 en-affil=Division of Neurology, Department of Medicine, Showa University, School of Medicine kn-affil= affil-num=19 en-affil=Department of Neurology, Faculty of Medicine, Oita University kn-affil= affil-num=20 en-affil=Department of Neurology, Faculty of Medicine, Oita University kn-affil= affil-num=21 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=22 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=23 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=24 en-affil=Department of Neurology, Himeji Central Hospital kn-affil= affil-num=25 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=26 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=27 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=28 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= en-keyword=AlzheimerБfs disease kn-keyword=AlzheimerБfs disease en-keyword=biomarker kn-keyword=biomarker en-keyword=coagulation kn-keyword=coagulation en-keyword=complement kn-keyword=complement en-keyword=MALDI-TOF kn-keyword=MALDI-TOF en-keyword=mild cognitive impairment kn-keyword=mild cognitive impairment en-keyword=neuroinflammation kn-keyword=neuroinflammation en-keyword=peptidome kn-keyword=peptidome en-keyword=plasticity kn-keyword=plasticity END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=100284 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A case of type 1 facioscapulohumeral muscular dystrophy (FSHD) with restrictive ventilatory defect and congestive heart failure en-subtitle= kn-subtitle= en-abstract= kn-abstract=[Background] Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disease characterized by asymmetric involvement of muscles in the face, upper extremity, trunk, and lower extremity regions, with variable severity. It was recently reported that restrictive respiratory involvement is more frequent and severe than previously recognized, while cardiac dysfunction other than arrhythmia is still considered extremely rare in FSHD. [Case report] A 59-year-old man presenting with marked muscle atrophy in the trunk and asymmetrical muscle atrophy in the legs was hospitalized because of dyspnea and edema in the face and limbs. Shortness of breath with body movement started from approximately 40?years of age. Muscle biopsy revealed myopathic change with mild to moderate variation in fiber size. The diagnosis of FSHD was made by D4Z4 contraction to three repeats on genetic testing. A pulmonary function test revealed a decline of forced vital capacity (FVC) and a preserved FEV1/FVC indicating restrictive ventilatory defect (RVD). Ultrasonic echocardiogram (UCG) showed diffuse left ventricular hypokinesis, ventricular septum thickening, pericardial effusion, and decreased ejection fraction (LVEF 30%). [Conclusion] Although restrictive ventilatory defect and congestive heart failure are uncommon in FSHD, respiratory and cardiac evaluation may be necessary in patients with FSHD. en-copyright= kn-copyright= en-aut-name=MorimotoNobutoshi en-aut-sei=Morimoto en-aut-mei=Nobutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoMizuki en-aut-sei=Morimoto en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakamiyaMotonori en-aut-sei=Takamiya en-aut-mei=Motonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishinoIchizo en-aut-sei=Nishino en-aut-mei=Ichizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Neurology, Kagawa Central Prefectural Hospital kn-affil= affil-num=2 en-affil=Department of Neurology, Kagawa Central Prefectural Hospital kn-affil= affil-num=3 en-affil=Department of Neurology, Kagawa Central Prefectural Hospital kn-affil= affil-num=4 en-affil=Department of Neurology, Kagawa Central Prefectural Hospital kn-affil= affil-num=5 en-affil=Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP) kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Facioscapulohumeral muscular dystrophy (FSHD) kn-keyword=Facioscapulohumeral muscular dystrophy (FSHD) en-keyword=Restrictive ventilatory defect (RVD) kn-keyword=Restrictive ventilatory defect (RVD) en-keyword=Congestive heart failure (CHF) kn-keyword=Congestive heart failure (CHF) END start-ver=1.4 cd-journal=joma no-vol=132 cd-vols= no-issue=2 article-no= start-page=92 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cyber-physical engineering informatics research core kn-title=ГTГCГoБ[ГtГBГWГJГЛПюХёЙЮЧpМдЛЖГRГAБiCypherБjР▌ЧзВ╔В┬ВвВ─ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name=ИвХФЛзРL kn-aut-sei=ИвХФ kn-aut-mei=ЛзРL aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@ГwГЛГXГVГXГeГАУЭНЗЙ╚КwМдЛЖЙ╚ en-keyword=AI kn-keyword=AI en-keyword=Bigdata kn-keyword=Bigdata en-keyword=IoT kn-keyword=IoT END start-ver=1.4 cd-journal=joma no-vol=132 cd-vols= no-issue=2 article-no= start-page=87 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of paraneoplastic neurological syndrome associated with Hodgkin lymphoma kn-title=ГzГWГLГУГКГУГpОюВ╠ОбЧ├В╔ВцВшР_МoП╟ПєВ╠Й№СPВЁФFВ▀В╜ЦTОюсЗРлР_МoП╟МєМQВ╠1 Чс en-subtitle= kn-subtitle= en-abstract= kn-abstract=Б@An 86-year-old man was admitted to another hospital with ataxia and general fatigue. Brain MRI scan revealed a high-intensity area in the bilateral thalamus, and he was referred to Okayama University Hospital for detailed examination. Cerebrospinal fluid (CSF) and blood tests showed no evidence of infection or autoimmune encephalitis. An FDG-PET/CT scan revealed systemic lymphadenopathy, and cervical lymph node biopsy showed classical Hodgkin lymphoma. Neurological symptoms were suspicious of paraneoplastic neurological syndrome (PNS), but onco-neural antibodies were not detected in either serum or CSF. He was referred to our hospital, Okayama Red Cross Hospital, for treatment and administered 6 cycles of an ABVD regimen, and an FDG-PET/CT scan showed a complete remission. The brain lesion disappeared and neurological symptoms were improved, so he was diagnosed with PNS. PNS is rare complication associated with malignant lymphoma and early diagnosis is important because neurological symptoms can be improved with anti-cancer treatment. en-copyright= kn-copyright= en-aut-name=IkemachiRyosuke en-aut-sei=Ikemachi en-aut-mei=Ryosuke kn-aut-name=ТrТмЧ┴Йю kn-aut-sei=ТrТм kn-aut-mei=Ч┴Йю aut-affil-num=1 ORCID= en-aut-name=KondoKaho en-aut-sei=Kondo en-aut-mei=Kaho kn-aut-name=Л▀УбЙ╠Хф kn-aut-sei=Л▀Уб kn-aut-mei=Й╠Хф aut-affil-num=2 ORCID= en-aut-name=MatumuraAkihumi en-aut-sei=Matumura en-aut-mei=Akihumi kn-aut-name=П╝С║П▓Х╢ kn-aut-sei=П╝С║ kn-aut-mei=П▓Х╢ aut-affil-num=3 ORCID= en-aut-name=FujiiSoichiro en-aut-sei=Fujii en-aut-mei=Soichiro kn-aut-name=УбИфСНИъШY kn-aut-sei=УбИф kn-aut-mei=СНИъШY aut-affil-num=4 ORCID= en-aut-name=TakeuchiMakoto en-aut-sei=Takeuchi en-aut-mei=Makoto kn-aut-name=Т|УрР╜ kn-aut-sei=Т|Ур kn-aut-mei=Р╜ aut-affil-num=5 ORCID= en-aut-name=SatoKouta en-aut-sei=Sato en-aut-mei=Kouta kn-aut-name=Н▓УбНPС╛ kn-aut-sei=Н▓Уб kn-aut-mei=НPС╛ aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=7 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=ЛgЦьР│ kn-aut-sei=ЛgЦь kn-aut-mei=Р│ aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Hematology, Okayama Red Cross Hospital kn-affil=ЙкОRР╘П\ОЪХaЙ@Б@ММЙtУрЙ╚ affil-num=2 en-affil=Department of Hematology, Okayama Red Cross Hospital kn-affil=ЙкОRР╘П\ОЪХaЙ@Б@ММЙtУрЙ╚ affil-num=3 en-affil=Department of Hematology, Okayama Red Cross Hospital kn-affil=ЙкОRР╘П\ОЪХaЙ@Б@ММЙtУрЙ╚ affil-num=4 en-affil=Department of Hematology, Okayama Red Cross Hospital kn-affil=ЙкОRР╘П\ОЪХaЙ@Б@ММЙtУрЙ╚ affil-num=5 en-affil=Department of Hematology, Okayama Red Cross Hospital kn-affil=ЙкОRР╘П\ОЪХaЙ@Б@ММЙtУрЙ╚ affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=8 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ХaЧЭКwБiОюсЗХaЧЭБj en-keyword=ЦTОюсЗРлР_МoП╟МєМQ (paraneoplastic neurological syndrome) kn-keyword=ЦTОюсЗРлР_МoП╟МєМQ (paraneoplastic neurological syndrome) en-keyword=ИлРлГКГУГpОю (malignant lymphoma) kn-keyword=ИлРлГКГУГpОю (malignant lymphoma) END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=17102 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201013 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. Muse cells are endogenous reparative pluripotent-like stem cells distributed in various tissues. They can selectively home to damaged sites after intravenous injection by sensing sphingosine-1-phosphate produced by damaged cells, then exert pleiotropic effects, including tissue protection and spontaneous differentiation into tissue-constituent cells. In G93A-transgenic ALS mice, intravenous injection of 5.0x10(4) cells revealed successful homing of human-Muse cells to the lumbar spinal cords, mainly at the pia-mater and underneath white matter, and exhibited glia-like morphology and GFAP expression. In contrast, such homing or differentiation were not recognized in human mesenchymal stem cells but were instead distributed mainly in the lung. Relative to the vehicle groups, the Muse group significantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles. These results suggest that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of ALS patients. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KushidaYoshihiro en-aut-sei=Kushida en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WakaoShohei en-aut-sei=Wakao en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DezawaMari en-aut-sei=Dezawa en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Mesenchymal stem cells kn-keyword=Mesenchymal stem cells en-keyword=Neurological disorders kn-keyword=Neurological disorders END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=7 article-no= start-page=41 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Т╖Х╥ПмРрВ╠К╙П▄ООШ_Б\Б\ОЦП█БiРSП█БjВ╞РlК╘СЬВ╠СКК╓ФcИмВ╓В╠ГAГvГНБ[Г`Б\Б\БhИвХФТmУёБuУ~В╠ПhБvВЁСfН▐В╔Бh en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ПуС║У╓ФV kn-aut-sei=ПуС║ kn-aut-mei=У╓ФV aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Т├ОRПдЛ╞НВУЩКwНZ END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=156 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report the first case of SANM with acute respiratory failure treated with noninvasive pressure support ventilation in addition to immunosuppressants.
Case presentation: A 59-year-old woman who had been treated with 2.5 mg/day of rosuvastatin calcium for 5 years stopped taking the drug 4 months before admission to our hospital due to elevation of creatine kinase (CK). Withdrawal of rosuvastatin for 1 month did not decrease the level of CK, and she was admitted to our hospital due to the development of muscle weakness of her neck and bilateral upper extremities. Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies were positive. Magnetic resonance imaging showed myositis, and muscle biopsy from the right biceps brachii muscle showed muscle fiber necrosis and regeneration without inflammatory cell infiltration, suggesting SANM. After the diagnosis, she received methylprednisolone pulse therapy (mPSL, 1 g/day Б~ 3 days, twice) and subsequent oral prednisolone therapy (PSL, 30 mg/day for 1 month, 25 mg/day for 1 month and 22.5 mg/day for 1 month), leading to improvement of her muscle weakness. One month after the PSL tapering to 20 mg/day, her muscle weakness deteriorated with oxygen desaturation (SpO2: 93% at room air) due to hypoventilation caused by weakness of respiratory muscles. BIPAP was used for the management of acute respiratory failure in combination with IVIG (20 g/day Б~ 5 days) followed by mPSL pulse therapy (1 g/day Б~ 3 days), oral PSL (30 mg/day Б~ 3 weeks, then tapered to 25 mg/day) and tacrolimus (3 mg/day). Twenty-seven days after the start of BIPAP, she was weaned from BIPAP with improvement of muscle weakness, hypoxemia and hypercapnia. After she achieved remission with improvement of muscle weakness and reduction of serum CK level to a normal level, the dose of oral prednisolone was gradually tapered to 12.5 mg/day without relapse for 3 months.
Conclusions: Our report provides new insights into the role of immunosuppressants and biphasic positive airway pressure for induction of remission in patients with SANM. en-copyright= kn-copyright= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Center for Rheumatology, Okayama Saiseikai General Hospital kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Noninvasive pressure support ventilation kn-keyword=Noninvasive pressure support ventilation en-keyword=Statin-associated necrotizing myopathy kn-keyword=Statin-associated necrotizing myopathy en-keyword=BIPAP kn-keyword=BIPAP END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=6 article-no= start-page=1974 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements en-subtitle= kn-subtitle= en-abstract= kn-abstract=Oxidative stress plays a crucial role in Alzheimer's disease (AD) from its prodromal stage of mild cognitive impairment. There is an interplay between oxidative stress and the amyloid beta (A beta) cascade via various mechanisms including mitochondrial dysfunction, lipid peroxidation, protein oxidation, glycoxidation, deoxyribonucleotide acid damage, altered antioxidant defense, impaired amyloid clearance, inflammation and chronic cerebral hypoperfusion. Based on findings that indicate that oxidative stress plays a major role in AD, oxidative stress has been considered as a therapeutic target of AD. In spite of favorable preclinical study outcomes, previous antioxidative components, including a single antioxidative supplement such as vitamin C, vitamin E or their mixtures, did not clearly show any therapeutic effect on cognitive decline in AD. However, novel antioxidative supplements can be beneficial for AD patients. In this review, we summarize the interplay between oxidative stress and the A beta cascade, and introduce novel antioxidative supplements expected to prevent cognitive decline in AD. en-copyright= kn-copyright= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InufusaHaruhiko en-aut-sei=Inufusa en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LoonAlan Foo Nyuk en-aut-sei=Loon en-aut-mei=Alan Foo Nyuk kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Anti-Oxidant Research, Life Science Research Center, Gifu University kn-affil= affil-num=4 en-affil=Hovid Berhad kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=supplement kn-keyword=supplement END start-ver=1.4 cd-journal=joma no-vol=2019 cd-vols= no-issue= article-no= start-page=143 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Speech-like Emotional Sound Generator by WaveNet en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, we propose a new algorithm to generate Speech-like Emotional Sound (SES). Emotional information plays an important role in human communication, and speech is one of the most useful media to express emotions. Although, in general, speech conveys emotional information as well as linguistic information, we have undertaken the challenge to generate sounds that convey emotional information without linguistic information, which results in making conversations in human-machine interactions more natural in some situations by providing non-verbal emotional vocalizations. We call the generated sounds Бgspeech-likeБh, because the sounds do not contain any linguistic information. For the purpose, we propose to employ WaveNet as a sound generator conditioned by only emotional IDs. The idea is quite different from WaveNet Vocoder that synthesizes speech using spectrum information as auxiliary features. The biggest advantage of the idea is to reduce the amount of emotional speech data for the training. The proposed algorithm consists of two steps. In the first step, WaveNet is trained to obtain phonetic features using a large speech database, and in the second step, WaveNet is re-trained using a small amount of emotional speech. Subjective listening evaluations showed that the SES could convey emotional information and was judged to sound like a human voice. en-copyright= kn-copyright= en-aut-name=MatsumotoKento en-aut-sei=Matsumoto en-aut-mei=Kento kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HaraSunao en-aut-sei=Hara en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=5 article-no= start-page=288 end-page=290 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis en-subtitle= kn-subtitle= en-abstract= kn-abstract= We found a late presented congenital myasthenic syndrome (CMS) patient with novel CHRNE gene mutations. Although our patient has shown blepharoptosis since youth, fatigable muscle weakness began at age 71. Genetic analysis revealed novel compound heterozygous CHRNE mutations (c.1032+2T>G, c.1306_1307 delGA). His myasthenic symptoms were well managed by oral antiБ]cholinesterase drug until he died at 82Б]yearБ]old. The present case showed mild myasthenic symptoms with very late presentation and slow progression. Late presented CMS is often underdiagnosed; therefore, genetic testing is important to distinguish it from other myasthenic disease. en-copyright= kn-copyright= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuiJun en-aut-sei=Mitsui en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TodaTatsushi en-aut-sei=Toda en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=anti-cholinesterase drug kn-keyword=anti-cholinesterase drug en-keyword=the CHRNE gene kn-keyword=the CHRNE gene en-keyword=congenital myasthenic syndrome kn-keyword=congenital myasthenic syndrome en-keyword=late presentation kn-keyword=late presentation en-keyword=mimicking seronegative myasthenia gravis kn-keyword=mimicking seronegative myasthenia gravis END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=5 article-no= start-page=607 end-page=609 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but the neuroprotective mechanism for the oxidative stress of ALS has not been fully investigated. In this study, we investigated oxidative stress in ALS model mice bearing both oxidative stress sensor nuclear erythroid 2-related factor 2 (Nrf2) and G93A-human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. In vivo Nrf2 imaging analysis showed the accelerated oxidative stress both in spinal motor neurons and lower limb muscles of Nrf2/G93A mice according to disease progression in addition to the enhancement of serum oxidative stress marker dROMS. These were significantly alleviated by edaravone treatment accompanied by clinical improvements (rotarod test). The present study suggests that in vivo optical imaging of Nrf2 is useful for detecting oxidative stress in ALS, and edaravone alleviates the degeneration of both motor neurons and muscles related to oxidative stress in ALS patients. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ALS kn-keyword=ALS en-keyword=SOD1 kn-keyword=SOD1 en-keyword=edaravone kn-keyword=edaravone en-keyword=in vivo imaging kn-keyword=in vivo imaging en-keyword=nrf2 kn-keyword=nrf2 en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=3 article-no= start-page=146 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Very rare solitary primary peripheral nerve onset cytotoxic molecule-positive peripheral T-cell lymphoma (PTCL) en-subtitle= kn-subtitle= en-abstract= kn-abstract= Here we present the first report of solitary primary peripheral nerve onset cytotoxic molecule (CM)-positive peripheral T-cell lymphoma (PTCL) diagnosed after nerve biopsy. An 84-year-old female with rheumatoid arthritis (RA) complained of asymmetric severe tenderness in her upper limbs. The biopsy pathology revealed a direct invasion of CM-positive PTCL. When RA patients complain of numbness, tenderness, or weakness, lymphomatic peripheral nerve invasion should be considered. en-copyright= kn-copyright= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SakamotoMaiko en-aut-sei=Sakamoto en-aut-mei=Maiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KondouEisei en-aut-sei=Kondou en-aut-mei=Eisei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ShibataRei en-aut-sei=Shibata en-aut-mei=Rei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Hematology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Hematology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Orthopedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=neurolymphomatosis kn-keyword=neurolymphomatosis en-keyword= neuro-oncology kn-keyword= neuro-oncology en-keyword=peripheral neuropathy kn-keyword=peripheral neuropathy en-keyword=peripheral nerve kn-keyword=peripheral nerve en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword= T-cell lymphoma kn-keyword= T-cell lymphoma END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=10956 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190729 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia en-subtitle= kn-subtitle= en-abstract= kn-abstract= The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5-2.0?Б~?107 /ul) of mock pMX-GFP (n?=?13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n?=?14) was directly injected into the ipsilateral striatum and cortex 3 days after 30?min of transient cerebral ischemia. The reprogrammed cells first expressed neuronal progenitor marker Dcx 7 and 21 days after viral injection, then expressed mature neuronal marker NeuN. This was accompanied by morphological changes, including long processes and synapse-like structures, 49 days after viral injection. Meanwhile, therapeutic improvement was not detected both in clinical scores or infarct volume. The present study provides a future novel self-repair strategy for ischemic stroke with beneficial modifications of the inducer-suppressor balance. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=4 article-no= start-page=1667 end-page=1675 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190423 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model en-subtitle= kn-subtitle= en-abstract= kn-abstract= Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novel AD model (APP23) with HP at 12 month of age. As compared with wild type (WT, n?=?10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23?+?HP group (n?=?12) than the simple APP23 (n?=?10) group (*p? The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and Г┐-synuclein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX).
METHODS:
APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradually decrease the cerebral blood flow. The effects of the administration of TwX were evaluated by immunohistochemical analysis and Immunofluorescent histochemistry.
RESULTS:
The present study revealed that the expressions of phospho-tau and phospho-Г┐-synuclein were significantly increased in the APP23?+?CCH mice group as compared with wild type and APP23 mice groups (*P < .05 and ??P < .01 versus WT; #P < .05 and ##P < .01 versus APP23). In addition, CCH significantly exacerbated MMP-9 activation relating to blood-brain barrier destruction (??P < .01 versus WT; #P < .05, and ##P < .01 versus APP23), enhanced neurovascular remodeling, and impaired a neurovascular trophic coupling in the vascular endothelial BDNF expression of the APP23?+?CCH group. TwX treatment (20 mg/kg/day, from 4.5 to 12 months) significantly reduced tau and Г┐-synuclein pathologies, ameliorated neurovascular dysfunction compared with APP23?+?CCH group.
CONCLUSIONS:
Our findings indicate that administration of a new antioxidative mixture TwX substantially reduced the above neuropathologic abnormalities, suggesting a potential therapeutic benefit of TwX for AD with CCH. en-copyright= kn-copyright= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=APP23 mice kn-keyword=APP23 mice en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=chronic cerebral hypoperfusion kn-keyword=chronic cerebral hypoperfusion en-keyword=neurovascular dysfunction kn-keyword=neurovascular dysfunction en-keyword=phosphorylated tau kn-keyword=phosphorylated tau en-keyword=Г┐-synuclein kn-keyword=Г┐-synuclein END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=6 article-no= start-page=351 end-page=353 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A unique stroke case with contralateral sulcal hyperintensity on fluid-attenuated inversion recovery image changed to linear serpiginous structures en-subtitle= kn-subtitle= en-abstract= kn-abstract= An 83-year-old man developed acute ischemic stroke. Brain magnetic resonance imaging (MRI) showed ischemic stroke in the left parietal lobe gyri, but fluid-attenuated inversion recovery (FLAIR) showed hyperintensity in the contralateral right temporal-occipital lobe sulci. Follow-up FLAIR image showed the gradual disappearance of the sulcal hyperintensity in the sulci and changed to linear serpiginous structures. This is a unique stroke case showing transitioned FLAIR findings suggesting that the sulcal hyperintensity findings are more severe and an earlier ischemic condition than the linear serpiginous structures. en-copyright= kn-copyright= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cerebrovascular disease kn-keyword=cerebrovascular disease en-keyword=FLAIR kn-keyword=FLAIR en-keyword=imaging kn-keyword=imaging en-keyword=linear serpiginous structure kn-keyword=linear serpiginous structure en-keyword=sulcal hyperintensity kn-keyword=sulcal hyperintensity END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=4 article-no= start-page=215 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A pneumococcal meningoencephalitis with a small spleen en-subtitle= kn-subtitle= en-abstract= kn-abstract= Streptococcus pneumoniae is a major cause of bacterial meningitis usually in children or elder adults. We report a case of a 38-year-old man having pneumococcal meningoencephalitis with a small spleen (35 cm(3)), compared to seven previous patients with pneumococcal meningitis in our department. Among the eight patients, four cases were due to sinusitis, but the origin could not be identified in the other four cases, including the present case who was the youngest patient with the smallest splenic size. Of interest in the present analysis was the negative or positive correlation between splenic size and age, with or without sinusitis. This is the first report on pneumococcal meningoencephalitis that takes into consideration age, splenic size, and the origin of infection. en-copyright= kn-copyright= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil= kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=age kn-keyword=age en-keyword=meningoencephalitis kn-keyword=meningoencephalitis en-keyword=sinusitis kn-keyword=sinusitis en-keyword=small spleen kn-keyword=small spleen en-keyword=Streptococcus pneumoniae kn-keyword=Streptococcus pneumoniae END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=11 article-no= start-page=1001 end-page=1007 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191005 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives:
Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals.
Methods:
A total of 385 subjects (72 males and 313 females, 75.5 Б} 8.7 years old) participated in a 12-month (M) exercise program at a health and welfare center, a day service center, and a nursing home. Cognitive, affective, and physical functions, and activities of daily living (ADL), were compared at baseline (0M), 6M and 12M of exercise intervention.
Results:
Mean scores on the frontal assessment battery, clock drawing test, cube copying test, letter fluency, and category fluency significantly improved after the Yoga-plus intervention, while mini-mental state examination, Hasegawa dementia score-revised, and trail-making test performance were relatively stable. Affective scores on the geriatric depression scale (GDS), apathy scale (AS) and Abe's behavioral and psychological symptoms of dementia were not significantly affected by exercise therapy, but subgroups with higher baseline GDS (GDS ? 5) and AS (AS ? 16) scores showed a significant improvement after intervention. One-leg standing time and 3-m timed up and go test performance significantly improved after 12M intervention.
Discussion:
Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals. en-copyright= kn-copyright= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiYoriko en-aut-sei=Takahashi en-aut-mei=Yoriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TokuchiRyo en-aut-sei=Tokuchi en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FurusawaJunichi en-aut-sei=Furusawa en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Education, Nippon Ayurveda School kn-affil= affil-num=3 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Occupational Therapy, Okayama Institute for Medical and Technical Sciences kn-affil= affil-num=5 en-affil=Department of Occupational Therapy, Mizunaga Rehabilitation Hospital kn-affil= affil-num=6 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Affective function kn-keyword=Affective function en-keyword=cognitive function kn-keyword=cognitive function en-keyword=elderly population kn-keyword=elderly population en-keyword=physical function kn-keyword=physical function en-keyword=yoga exercise kn-keyword=yoga exercise END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=7 article-no= start-page=1993 end-page=2002 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND:
Multiple pathogeneses are involved in Alzheimer's disease (AD), such as amyloid-Г└ accumulation, neuroinflammation, and oxidative stress. The pathological impact of chronic cerebral hypoperfusion on Alzheimer's disease is still poorly understood.
METHODS:
APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive chronic cerebral hypoperfusion (CCH). The effects of the administration of Twendee X (TwX) were evaluated by behavioral analysis, immunohistochemical analysis, and immunofluorescent histochemistry.
RESULTS:
In the present study, chronic cerebral hypoperfusion, which is commonly found in aged Alzheimer's disease, significantly exacerbated motor dysfunction of APP23 mice from 5 months and cognitive deficit from 8 months of age, as well as neuronal loss, extracellular amyloid-Г└ plaque and intracellular oligomer formations, and amyloid angiopathy at 12 months. Severe upregulations of oxidative markers and inflammatory markers were found in the cerebral cortex, hippocampus, and thalamus at 12 months. Twendee X treatment (20 mg/kg/d, from 4.5 to 12 months) substantially rescued the cognitive deficit and reduced the above amyloid-Г└ pathology and neuronal loss, alleviated neuroinflammation and oxidative stress.
CONCLUSIONS:
The present findings suggested a potential therapeutic benefit of Twendee X for Alzheimer's disease with chronic cerebral hypoperfusion. en-copyright= kn-copyright= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=APP23 mice kn-keyword=APP23 mice en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=anti-inflammatory kn-keyword=anti-inflammatory en-keyword=antioxidative kn-keyword=antioxidative en-keyword=chronic cerebral hypoperfusion kn-keyword=chronic cerebral hypoperfusion END start-ver=1.4 cd-journal=joma no-vol=400 cd-vols= no-issue= article-no= start-page=145 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190515 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A unique Japanese CPEO family with a novel homozygous m.14819?T?>?G (p. S25A) substitution en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GotoYu-ichi en-aut-sei=Goto en-aut-mei=Yu-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Medical Genome Center (MGC), Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience (NIN), National Center of Neurology and Psychiatry kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=CPEO kn-keyword=CPEO en-keyword=Homozygous kn-keyword=Homozygous en-keyword=Mitochondrial DNA kn-keyword=Mitochondrial DNA END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue= article-no= start-page=13 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Latest Trends Concerning Misconduct and Compliance kn-title=ХsП╦ОЦВ╞ГRГУГvГЙГCГAГУГXВЁПДВщЛ▀ОЮВ╠УоМ№В╔В┬ВвВ─ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtsukiMasahiro en-aut-sei=Otsuki en-aut-mei=Masahiro kn-aut-name=СхМОЙыФО kn-aut-sei=СхМО kn-aut-mei=ЙыФО aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ИвХФБEИфМEБEХ╨ОRЦ@ЧеОЦЦ▒ПК END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=19 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report on the Death of Norihide Abe in China kn-title=ТЖНСНСУрУIИвХФ?ПGОАЦS?? en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JiangKeshi en-aut-sei=Jiang en-aut-mei=Keshi kn-aut-name=ЫIНОЫЙ kn-aut-sei=ЫI kn-aut-mei=НОЫЙ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@О╨ЙяХ╢Й╗Й╚КwМдЛЖЙ╚ END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=1 article-no= start-page=43 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 7th Annual Meeting of Japan Society for Dementia Prevention kn-title=Сц7ЙёУ·Ц{ФFТmП╟Ч\ЦhКwЙяКwПpПWЙяХёНР en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentlstry and Pharmaceutical Sciences kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=111 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis kn-title=Й╞С░РлСхТ░СBОюП╟ПpМу20ФNМуВ╔ПмТ░КрВЁФнП╟В╡В╜1Чс en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=РЩМ┤ЧYНЇ kn-aut-sei=РЩМ┤ kn-aut-mei=ЧYНЇ aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=РьЦьР╜Оi kn-aut-sei=РьЦь kn-aut-mei=Р╜Оi aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=М┤УcК]С╛ kn-aut-sei=М┤Уc kn-aut-mei=К]С╛ aut-affil-num=3 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=НВУИОuХ█ kn-aut-sei=НВУИ kn-aut-mei=ОuХ█ aut-affil-num=4 ORCID= en-aut-name=TakeiDaisuke en-aut-sei=Takei en-aut-mei=Daisuke kn-aut-name=Т|ИфСхЙю kn-aut-sei=Т|Иф kn-aut-mei=СхЙю aut-affil-num=5 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=ИфМ√ПrФО kn-aut-sei=ИфМ√ kn-aut-mei=ПrФО aut-affil-num=6 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=НВМ┤РнНG kn-aut-sei=НВМ┤ kn-aut-mei=РнНG aut-affil-num=7 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=Х╜ЙкН▓ЛKОq kn-aut-sei=Х╜Йк kn-aut-mei=Н▓ЛKОq aut-affil-num=8 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name=ХъЧвПiОq kn-aut-sei=ХъЧв kn-aut-mei=ПiОq aut-affil-num=9 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name=К▌Ц{Н_Нs kn-aut-sei=К▌Ц{ kn-aut-mei=Н_Нs aut-affil-num=10 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=ЙiНтКxОi kn-aut-sei=ЙiНт kn-aut-mei=КxОi aut-affil-num=11 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=ЙкУcЧTФV kn-aut-sei=ЙкУc kn-aut-mei=ЧTФV aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@МїКwИуЧ├РfЧ├ХФ affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@МїКwИуЧ├РfЧ├ХФ affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ affil-num=9 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗К╟КOЙ╚ affil-num=10 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗К╟КOЙ╚ affil-num=11 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗К╟КOЙ╚ affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=ЙкОRСхКwХaЙ@Б@П┴Й╗КэУрЙ╚ en-keyword=Й╞С░РлСхТ░СBОюП╟ (familial adenomatous polyposis) kn-keyword=Й╞С░РлСхТ░СBОюП╟ (familial adenomatous polyposis) en-keyword=ПмТ░Кр (jejunal cancer) kn-keyword=ПмТ░Кр (jejunal cancer) en-keyword=ПмТ░УрОЛЛ╛МЯН╕ (small intestine endoscope) kn-keyword=ПмТ░УрОЛЛ╛МЯН╕ (small intestine endoscope) END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=5 article-no= start-page=e67 end-page=e69 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuzonoKosuke en-aut-sei=Matsuzono en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LiuWentao en-aut-sei=Liu en-aut-mei=Wentao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DeguchiShoko en-aut-sei=Deguchi en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry kn-affil= en-keyword=Prion disease kn-keyword=Prion disease en-keyword=Novelgene mutation kn-keyword=Novelgene mutation en-keyword=2bp deletion in codon 178 kn-keyword=2bp deletion in codon 178 en-keyword=stopcodon at codon 195 kn-keyword=stopcodon at codon 195 en-keyword=Sensoryneuropathy kn-keyword=Sensoryneuropathy en-keyword=HSAN kn-keyword=HSAN en-keyword=Pan-autonomicfailure kn-keyword=Pan-autonomicfailure en-keyword=Familial case kn-keyword=Familial case END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=221 end-page=225 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practice for health care education using simulated patients kn-title=Ц═Л[К│О╥БiSPБjОQЙ┴М^Л│ИчВ╠О└СH en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YoshidaToshiko en-aut-sei=Yoshida en-aut-mei=Toshiko kn-aut-name=ЛgУcУoОuОq kn-aut-sei=ЛgУc kn-aut-mei=УoОuОq aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for the Development of Medical and Health Care EducationБi Dental EducationБj, Okayama University kn-affil=ЙкОRСхКwИуЧ├Л│ИчУЭНЗКJФнГZГУГ^Б[БiОХКwЛ│ИчХФЦхБj en-keyword=Ц═Л[К│О╥ kn-keyword=Ц═Л[К│О╥ en-keyword=ГtГBБ[ГhГoГbГN kn-keyword=ГtГBБ[ГhГoГbГN en-keyword=МoМ▒КwПC kn-keyword=МoМ▒КwПC en-keyword=ИуЧ├Л│Ич kn-keyword=ИуЧ├Л│Ич END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sound collection systems using a crowdsourcing approach to construct sound map based on subjective evaluation en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper presents a sound collection system that uses crowdsourcing to gather information for visualizing area characteristics. First, we developed a sound collection system to simultaneously collect physical sounds, their statistics, and subjective evaluations. We then conducted a sound collection experiment using the developed system on 14 participants. We collected 693,582 samples of equivalent Aweighted loudness levels and their locations, and 5,935 samples of sounds and their locations. The data also include subjective evaluations by the participants. In addition, we analyzed the changes in sound properties of some areas before and after the opening of a large-scale shopping mall in a city. Next, we implemented visualizations on the server system to attract usersБf interests. Finally, we published the system, which can receive sounds from any Android smartphone user. The sound data were continuously collected and achieved a specified result. en-copyright= kn-copyright= en-aut-name=HaraSunao en-aut-sei=Hara en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KobayashiShota en-aut-sei=Kobayashi en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate school of Natural Science and Technology, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ affil-num=2 en-affil=Graduate school of Natural Science and Technology, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ affil-num=3 en-affil=Graduate school of Natural Science and Technology, Okayama University kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ en-keyword=Environmental sound kn-keyword=Environmental sound en-keyword=Crowdsourcing kn-keyword=Crowdsourcing en-keyword=Loudness kn-keyword=Loudness en-keyword=Crowdedness kn-keyword=Crowdedness en-keyword=Smart City kn-keyword=Smart City END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=205 end-page=211 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy en-subtitle= kn-subtitle= en-abstract= kn-abstract=A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAP?s effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (pББ0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (pББ0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects. en-copyright= kn-copyright= en-aut-name=KozakiKen-ichi en-aut-sei=Kozaki en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawakamiShigehisa en-aut-sei=Kawakami en-aut-mei=Shigehisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonishiTakayuki en-aut-sei=Konishi en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaKeiji en-aut-sei=Ohta en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoJitsuro en-aut-sei=Yano en-aut-mei=Jitsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IidaSeiji en-aut-sei=Iida en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=GofukuAkio en-aut-sei=Gofuku en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MinagiShogo en-aut-sei=Minagi en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=Okayama Dream Speech Project en-aut-sei=Okayama Dream Speech Project en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University Hospital kn-affil= affil-num=4 en-affil=Dental Laboratory Division, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=13 en-affil=Department of Computer Science, Okayama University kn-affil= affil-num=14 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil= kn-affil= en-keyword=palatal augmentation prosthesis kn-keyword=palatal augmentation prosthesis en-keyword=artificial tongue kn-keyword=artificial tongue en-keyword=articulation disorder kn-keyword=articulation disorder en-keyword=glossectomy kn-keyword=glossectomy en-keyword=mandibulectomy kn-keyword=mandibulectomy END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=223 end-page=226 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Spoken Dialog System with Redundant Response to Prevent User Misunderstanding en-subtitle= kn-subtitle= en-abstract= kn-abstract=We propose a spoken dialog strategy for car navigation systems to facilitate safe driving. To drive safely, drivers need to concentrate on their driving; however, their concentration may be disrupted due to disagreement with their spoken dialog system. Therefore, we need to solve the problems of user misunderstandings as well as misunderstanding of spoken dialog systems. For this purpose, we introduced a driver workload level in spoken dialog management in order to prevent user misunderstandings. A key strategy of the dialog management is to make speech redundant if the driverБfs workload is too high in assuming that the user probably misunderstand the system utterance under such a condition. An experiment was conducted to compare performances of the proposed method and a conventional method using a user simulator. The simulator is developed under the assumption of two types of drivers: an experienced driver model and a novice driver model. Experimental results showed that the proposed strategies achieved better performance than the conventional one for task completion time, task completion rate, and userБfs positive speech rate. In particular, these performance differences are greater for novice users than for experienced users. en-copyright= kn-copyright= en-aut-name=YamaokaMasaki en-aut-sei=Yamaoka en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HaraSunao en-aut-sei=Hara en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ affil-num=3 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=2 article-no= start-page=161 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 26th Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism kn-title=Сц26ЙёУ·Ц{Ф]ПzК┬СуО╙КwЙяСНЙяХёНР en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚ END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=145 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3Г└ under Oxidative Stress en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3Г└ signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3Г└ pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. en-copyright= kn-copyright= en-aut-name=IshiiHiroko en-aut-sei=Ishii en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KamikawaShigeshi en-aut-sei=Kamikawa en-aut-mei=Shigeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirohataSatoshi en-aut-sei=Hirohata en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MizutaniAkifumi en-aut-sei=Mizutani en-aut-mei=Akifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SenoMasaharu en-aut-sei=Seno en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OohashiToshitaka en-aut-sei=Oohashi en-aut-mei=Toshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NinomiyaYoshifumi en-aut-sei=Ninomiya en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=6 en-affil= kn-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine affil-num=8 en-affil= kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine en-keyword=ECP kn-keyword=ECP en-keyword=reactive oxygen species kn-keyword=reactive oxygen species en-keyword=Akt kn-keyword=Akt en-keyword=ERK kn-keyword=ERK END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ГКГУГpК╟ВЁЙюВ╡В╜ГEГVЙйС╠С▐НsВ╔К╓В╖ВщМдЛЖ kn-title=Study on Luteolysis Mechanisms via Lymphatic Vessels in Cow en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeHironori en-aut-sei=Abe en-aut-mei=Hironori kn-aut-name=ИвХФЧmУT kn-aut-sei=ИвХФ kn-aut-mei=ЧmУT aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ХsЛ╧ИъЧмС╠В╔ВиВпВщСКЛУУоВ╞ЧnФ}ШaВ╠РлО┐ kn-title=Phase Behavior and Solvation Properties in Inhomogeneous Fluids en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeKiharu en-aut-sei=Abe en-aut-mei=Kiharu kn-aut-name=ИвХФЛIЧy kn-aut-sei=ИвХФ kn-aut-mei=ЛIЧy aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=390 end-page=395 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sound collection and visualization system enabled participatory and opportunistic sensing approaches en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper presents a sound collection system to visualize environmental sounds that are collected using a crowd-sourcing approach. An analysis of physical features is generally used to analyze sound properties; however, human beings not only analyze but also emotionally connect to sounds. If we want to visualize the sounds according to the characteristics of the listener, we need to collect not only the raw sound, but also the subjective feelings associated with them. For this purpose, we developed a sound collection system using a crowdsourcing approach to collect physical sounds, their statistics, and subjective evaluations simultaneously. We then conducted a sound collection experiment using the developed system on ten participants.We collected 6,257 samples of equivalent loudness levels and their locations, and 516 samples of sounds and their locations. Subjective evaluations by the participants are also included in the data. Next, we tried to visualize the sound on a map. The loudness levels are visualized as a color map and the sounds are visualized as icons which indicate the sound type. Finally, we conducted a discrimination experiment on the sound to implement a function of automatic conversion from sounds to appropriate icons. The classifier is trained on the basis of the GMM-UBM (Gaussian Mixture Model and Universal Background Model) method. Experimental results show that the F-measure is 0.52 and the AUC is 0.79. en-copyright= kn-copyright= en-aut-name=HaraSunao en-aut-sei=Hara en-aut-mei=Sunao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SoneharaNoboru en-aut-sei=Sonehara en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=3 en-affil= kn-affil=National Institute of Informatics END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=237 end-page=239 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for treatment of chronic headache kn-title=ЦЭРлУкТ╔В╠РfЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuuraTohru en-aut-sei=Matsuura en-aut-mei=Tohru kn-aut-name=П╝ЙYУO kn-aut-sei=П╝ЙY kn-aut-mei=УO aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ОйОбИуЙ╚СхКwБ@УрЙ╚КwНuН└Р_МoУрЙ╚КwХФЦх affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=1473 cd-vols= no-issue= article-no= start-page=55 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120914 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impaired response of hypoxic sensor protein HIF-1 alpha and its downstream proteins in the spinal motor neurons of ALS model mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have recently reported spinal blood flow-metabolism uncoupling in an amyotrophic lateral sclerosis (ALS) animal model using Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mice, suggesting a relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway has not been well studied in ALS. Here, we examined temporal and spatial changes of the hypoxic stress sensor proteins HIF-1 alpha and its downstream proteins (VEGF, HO-1, and EPO) during the normcodccourse of motor neuron (MN) degeneration in the spinal cord of these ALS model mice. We found that HIP-1 alpha protein expression progressively increased both in the anterior large MNs and the surrounding glial cells in Tg mice from early symptomatic 14 week (W) and end stage 18W. Double immunofluorescence analysis revealed that HIP-1 alpha, plus GFAP and Iba-1 double-positive surrounding glial cells, progressively increased from 14 W to 18 W, although the immunohistochemistiy in large MNs did not change. Expression levels of VEGF and HO-1 also showed a progressive increase but were significant only in the surrounding glial cells at 18W. In contrast, EPO protein expression was decreased in the surrounding glial cells of Tg mice at 18W. Because HIF1-alpha serves as an important mediator of the hypoxic response, these findings indicate that MNs lack the neuroprotective response to hypoxic stress through the HIF-1 alpha system, which could be an important mechanism of neurodegeneration in ALS. en-copyright= kn-copyright= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoNobutoshi en-aut-sei=Morimoto en-aut-mei=Nobutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MimotoTakafumi en-aut-sei=Mimoto en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyazakiKazunori en-aut-sei=Miyazaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol en-keyword=ALS kn-keyword=ALS en-keyword=HIF-1 alpha kn-keyword=HIF-1 alpha en-keyword=VEGF kn-keyword=VEGF en-keyword=HO-1 kn-keyword=HO-1 en-keyword=EPO kn-keyword=EPO END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1 article-no= start-page=46 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reducing Hemorrhagic Complication by Dabigatran Via Neurovascular Protection After Recanalization With Tissue Plasminogen Activator in Ischemic Stroke of Rat en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study assesses the risks and benefits of tissue plasminogen activator (tPA) treatment under oral anticoagulation with dabigatran compared with warfarin or vehicle control in transient middle cerebral artery occlusion (tMCAO). After pretreatment with warfarin (0.2 mg/kg/day), dabigatran (20 mg/kg/day), or vehicle (0.5% carboxymethyl cellulose sodium salt) for 7 days, tMCAO was induced for 120 min, followed by reperfusion and tPA (10 mg/kg/10 ml). Clinical parameters, including cerebral infarction volume, hemorrhagic volume, and blood coagulation, were examined. At 24 hr after reperfusion, markers for the neurovascular unit at the peri-ischemic lesion were immunohistochemically examined in brain sections, and MMP-9 activity was measured by zymography. Paraparesis and intracerebral hemorrhage volume were significantly improved in the dabigatran-pretreated group compared with the warfarin-pretreated group. A marked dissociation between astrocyte foot processes and the basal lamina or pericyte was observed in the warfarin-pretreated group, which was greatly improved in the dabigatran-pretreated group. Furthermore, a remarkable activation of MMP-9 in the ipsilateral warfarin-pretreated rat brain was greatly reduced in dabigatran-pretreated rats. The present study reveals that the mechanism of intracerebral hemorrhage with warfarin-pretreatment plus tPA in ischemic stroke rats is the dissociation of the neurovascular unit, including the pericyte. Neurovascular protection by dabigatran, which was first shown in this study, could partially explain the reduction in hemorrhagic complication by dabigatran reported from clinical study. en-copyright= kn-copyright= en-aut-name=KonoSyoichiro en-aut-sei=Kono en-aut-mei=Syoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol en-keyword=dabigatran kn-keyword=dabigatran en-keyword=hemorrhagic complication kn-keyword=hemorrhagic complication en-keyword=neurovascular unit kn-keyword=neurovascular unit en-keyword=pericyte kn-keyword=pericyte en-keyword=thrombolysis kn-keyword=thrombolysis en-keyword=tPA kn-keyword=tPA END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=6 article-no= start-page=1639 end-page=1646 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to the Pleiotropic Effect of Cilostazol en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Purpose-Cerebral infarction is a major cause of death or decreasing activities of daily living. This study aimed to investigate the efficacy of commonly used antiplatelet drugs on stroke and motor and cognitive functions in relation to oxidative stress markers and insulin-like growth factor 1 receptor (IGF-1R). Methods-Stroke-prone spontaneously hypertensive rats were treated with vehicle, aspirin, clopidogrel, and cilostazol from 8 to 10 weeks of age. Physiological parameters, regional cerebral blood flow, and serum lipids were examined. Motor and cognitive functions were evaluated weekly by the Rotorod and water maze task. Spontaneous infarct volume, oxidative stress markers for lipid, protein, and DNA at the ischemic boundary zone of spontaneous infarction, and the IGF-1R-positive cell ratio in the hippocampus were immunohistochemically examined in brain sections. IGF-1R beta expression in the hippocampus was assessed by Western blotting. Results-The antiplatelet drugs, cilostazol and clopidogrel, reduced the spontaneous infarct volume more than aspirin. Only cilostazol improved motor and cognitive functions with a significant increase (P<0.05) in the memory-related IGF-1R-positive ratio and IGF-1R beta expression in the hippocampus. Cilostazol reduced the 4 oxidative stress markers in affected neurons in stroke-prone spontaneously hypertensive rats regardless of blood pressure, regional cerebral blood flow, or serum lipid levels. Conclusions-The present results suggest that a possible pleiotropic effect of cilostazol resulted in the reduction of spontaneous infarct volume and preservation of motor and spatial cognitive functions. The increase of IGF-1R-positive cells in the hippocampal CA1 region could partly explain the preservation of spatial cognitive function in stroke-prone spontaneously hypertensive rats. en-copyright= kn-copyright= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TianFengFeng en-aut-sei=Tian en-aut-mei=FengFeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawaiHiromi en-aut-sei=Kawai en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=cerebral infarction kn-keyword=cerebral infarction en-keyword=cilostazol kn-keyword=cilostazol en-keyword=IGF-1R kn-keyword=IGF-1R en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=SHR-SP kn-keyword=SHR-SP END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=155 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for the treatment of dementia kn-title=ФFТmП╟В╠ОбЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name=СqУcТqОq kn-aut-sei=СqУc kn-aut-mei=ТqОq aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@Р_МoУрЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of asymptomatic right-sided adult Bochdalek hernia presented incidentally with rectal tumor kn-title=Т╝Т░ОюсЗВЁМ_Л@В╔ФнМйВ│ВъВ╜Ц│П╟ПєВ╠РмРlЙEСдBochdalekНEГwГЛГjГAВ╠ВPЧс en-subtitle= kn-subtitle= en-abstract= kn-abstract=Б@We encountered a patient with an adult Bochdalek hernia discovered asymptomatically. A 77-year-old Japanese woman visited a local clinic with chief complaints of melena and difficulty in defecation. Based on the results of the detailed examination in our hospital, she was diagnosed with a rectal gastrointestinal stromal tumor (GIST) with a concurrent asymptomatic adult right-sided Bochdalek hernia. Because the tumor was large, laparoscopic abdominoperineal rectal amputation was performed after systemic imatinib therapy. During the surgery, we found a right diaphragmatic defect more than 13cm in long dia., through which the right hepatic lobe, colon, and greater omentum had prolapsed into the right thoracic cavity. No visceral adhesions were noted. No hernia sac was observed. Adult Bochdalek hernia is a relatively rare condition, and only three (incidentally discovered) cases of asymptomatic Bochdalek hernia, including the present case, have been reported in Japan. Here we provide a case report for the patient, who was followed-up without hernia surgery, plus a review of the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=Й┴УбСх kn-aut-sei=Й┴Уб kn-aut-mei=Сх aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=СхР╬Р│ФО kn-aut-sei=СхР╬ kn-aut-mei=Р│ФО aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=ПмОЫР│Рl kn-aut-sei=ПмОЫ kn-aut-mei=Р│Рl aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=ОRС║Х√Хv kn-aut-sei=ОRС║ kn-aut-mei=Х√Хv aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=ТrУcПGЦ╛ kn-aut-sei=ТrУc kn-aut-mei=ПGЦ╛ aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=РЕЦьМЫОб kn-aut-sei=РЕЦь kn-aut-mei=МЫОб aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=ОRЙ║ЧT kn-aut-sei=ОRЙ║ kn-aut-mei=ЧT aut-affil-num=7 ORCID= en-aut-name=SuzukiKazunori en-aut-sei=Suzuki en-aut-mei=Kazunori kn-aut-name=ЧщЦ╪ИъСе kn-aut-sei=ЧщЦ╪ kn-aut-mei=ИъСе aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=2 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=3 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=4 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=5 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=6 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=7 en-affil= kn-affil=Т╣ОцОsЧзХaЙ@Б@КOЙ╚ affil-num=8 en-affil= kn-affil=Т╣ОцР╢ЛжХaЙ@Б@КOЙ╚ en-keyword=РмРlBochdalekНEГwГЛГjГAБiadult Bochdalek herniaБj kn-keyword=РмРlBochdalekНEГwГЛГjГAБiadult Bochdalek herniaБj en-keyword=ХаНoЛ╛Й║ОшПpБilaparoscopic surgeryБj kn-keyword=ХаНoЛ╛Й║ОшПpБilaparoscopic surgeryБj END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=109 end-page=115 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comprehensive treatment for gender identity disorder kn-title=РлУпИъРлПсКQВ╔С╬В╖ВщХяКЗУIОбЧ├ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name=УяФgЧSОOШY kn-aut-sei=УяФg kn-aut-mei=ЧSОOШY aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@ГWГFГУГ_Б[ГZГУГ^Б[ en-keyword=РлУпИъРлПсКQ kn-keyword=РлУпИъРлПсКQ en-keyword=ХяКЗУIОбЧ├ kn-keyword=ХяКЗУIОбЧ├ en-keyword=РлХ╩УKНЗОшПp kn-keyword=РлХ╩УKНЗОшПp END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=55 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical guideline for epilepsy kn-title=В─ВёВйВёОбЧ├ГKГCГhГЙГCГУВ╔В┬ВвВ─ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MorimotoNobutoshi en-aut-sei=Morimoto en-aut-mei=Nobutoshi kn-aut-name=РXЦ{УWФN kn-aut-sei=РXЦ{ kn-aut-mei=УWФN aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=НБРьМзЧзТЖЙЫХaЙ@Б@Р_МoУрЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=111 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Survey of Skills-Based Integrated English Classes in the New Curriculum kn-title=ЙpМъРVГJГКГLГЕГЙГАВ╠ГXГLГЛХ╩Й╚Ц┌В╔К╓В╖ВщГAГУГPБ[ГgТ▓Н╕ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Б@ЙкОRСхКwВ┼В═Х╜Рм25ФNУxУ№КwО╥ВйВчЙpМъРVГJГКГLГЕГЙГАВЁУ▒У№В╡БAРVВPФNР╢В╠ГXГLГЛХ╩Й╚Ц┌В╠БuСННЗЙpМъВPБ|ВSБvБiГXГsБ[ГLГУГOБAГКБ[ГfГBГУГOБAГЙГCГeГBГУГOБAГКГXГjГУГOБjВ═ПKПnУxХ╩ГNГЙГXХ╥РмВЁНsВ┴В─ВвВщБBЦ{НeВ═БAМ╛МъЛ│ИчГZГУГ^Б[ЙpМъМnВкСOК·ЦЦВ╠ВVМОВ╔О└О{В╡В╜ОЎЛ╞ЦЮСлУxВ╔К╓В╖ВщГAГУГPБ[ГgТ▓Н╕МЛЙ╩ВЁХкР═В╡В╜ВрВ╠В┼ВаВщБBУ№КwОЮВSМОВ╠TOEIC IP ГXГRГA395У_И╚Й║БA400У_И╚Пу595У_И╚Й║БA600У_И╚ПуВ╠ПKПnУxХ╩ГOГЛБ[ГvВ╔ХкВп В─КwР╢В╠ОЎЛ╞ЦЮСлУxВ╠Х╜Л╧ТlВЁВ▌ВщВ╞БAПKПnУxВ╠ТсВвГOГЛБ[ГvВцВшВрНВВвГOГЛБ[ГvВ╠ЦЮСлУxВкНВВвМXМ№ВкВ▌ВчВъВ╜БBВ▄В╜БAОЎЛ╞ЦЮСлУxВ╔ЙeЛ┐ВЁЧ^ВжВщЧvИЎВ═БAПKПnУxХ╩ГOГЛБ[ГvВиВцВ╤ТSУЦЛ│ИїГOГЛБ[ГvВ╔ВцВ┴В─И┘В╚ВщВ▒В╞ВкВэВйВ┴В╜БB en-copyright= kn-copyright= en-aut-name=KenmotsuYoshi en-aut-sei=Kenmotsu en-aut-mei=Yoshi kn-aut-name=ЩЫОЭПi kn-aut-sei=ЩЫОЭ kn-aut-mei=Пi aut-affil-num=1 ORCID= en-aut-name=OtoshiJunko en-aut-sei=Otoshi en-aut-mei=Junko kn-aut-name=СхФNПЗОq kn-aut-sei=СхФN kn-aut-mei=ПЗОq aut-affil-num=2 ORCID= en-aut-name=AbeMasatoshi en-aut-sei=Abe en-aut-mei=Masatoshi kn-aut-name=ИвХФР│Хq kn-aut-sei=ИвХФ kn-aut-mei=Р│Хq aut-affil-num=3 ORCID= en-aut-name=OginoMasaru en-aut-sei=Ogino en-aut-mei=Masaru kn-aut-name=ЙмЦьПЯ kn-aut-sei=ЙмЦь kn-aut-mei=ПЯ aut-affil-num=4 ORCID= en-aut-name=TeranishiMasako en-aut-sei=Teranishi en-aut-mei=Masako kn-aut-name=ОЫР╝ЙыОq kn-aut-sei=ОЫР╝ kn-aut-mei=ЙыОq aut-affil-num=5 ORCID= en-aut-name=UzukaMariko en-aut-sei=Uzuka en-aut-mei=Mariko kn-aut-name=ЙFТ╦ЦЬЧвОq kn-aut-sei=ЙFТ╦ kn-aut-mei=ЦЬЧвОq aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ affil-num=2 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ affil-num=3 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ affil-num=4 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ affil-num=5 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ affil-num=6 en-affil= kn-affil=ЙкОRСхКwМ╛МъЛ│ИчГZГУГ^Б[ en-keyword=ГXГLГЛХ╩Й╚Ц┌ kn-keyword=ГXГLГЛХ╩Й╚Ц┌ en-keyword=ПKПnУxХ╩ГNГЙГX kn-keyword=ПKПnУxХ╩ГNГЙГX en-keyword=ОЎЛ╞ЦЮСлУx kn-keyword=ОЎЛ╞ЦЮСлУx END start-ver=1.4 cd-journal=joma no-vol=1397 cd-vols= no-issue= article-no= start-page=66 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Detection and protection of apoptosis, autophagy and neurovascular unit (NVU) are essentially important in understanding and treatment for ischemic stroke patients. In this study, we have conducted an in vivo optical imaging for detecting apoptosis and activation of matrix metalloproteinases (MMPs), then evaluated the protective effect of 2 package types of free radical scavenger edaravone (A and B) on apoptosis, autophagy and NVU in mice after transient middle cerebral artery occlusion (tMCAO). As compared to vehicle treatment, edaravones A and B showed a significant improvement of clinical scores and infarct size at 48 h after 90 min of tMCAO with great reductions of in vivo fluorescent signal for MMPs and early apoptotic annexin V activations. Ex vivo imaging of MMPSense 680 or annexin V-Cy5.5 showed a fluorescent signal, while which was remarkably different between vehicle and edaravone groups, and colocalized with antibody for MMP-9 or annexin V. Edaravone A and B ameliorated the apoptotic neuronal cell death in immunohistochemistry, and activations of MMP-9 and aquaporin 4 with reducing autophagic activations of microtubule-associated protein 1 light chain 3 (LC3) in Western blot. In this study, edaravone in both packages showed a similar strong neuroprotection after cerebral ischemia, which was confirmed with in vivo and ex vivo optical imagings for MMPs and annexin V as well as reducing cerebral infarct, inhibiting apoptotic/autophagic mechanisms, and protecting a part of neurovascular unit. en-copyright= kn-copyright= en-aut-name=LiuNing en-aut-sei=Liu en-aut-mei=Ning kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TianFengfeng en-aut-sei=Tian en-aut-mei=Fengfeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishiHiroyoshi en-aut-sei=Nishi en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Yokohama Coll Pharm, Dept Clin Pharmacol affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=Apoptosis kn-keyword=Apoptosis en-keyword=Autophagy kn-keyword=Autophagy en-keyword=Cerebral ischemia kn-keyword=Cerebral ischemia en-keyword=Edaravone kn-keyword=Edaravone en-keyword=In vivo imaging kn-keyword=In vivo imaging END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=257 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for treatment of bacterial meningitis kn-title=Н╫Л█РлРСЦМЙКВ╠ОбЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name=ТrУcЙ└Р╢ kn-aut-sei=ТrУc kn-aut-mei=Й└Р╢ aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=МQФnСхКwСхКwЙ@ИуКwМnМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=159 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for treatment of ischemic stroke kn-title=Ф]Н[Н╟В╠ОбЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name=ПoМ√МТС╛ШY kn-aut-sei=ПoМ√ kn-aut-mei=МТС╛ШY aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwХaЙ@ Р_МoУрЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚ Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=221 cd-vols= no-issue= article-no= start-page=47 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- andtissue plasminogen activator-related brain damages in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Reactive oxygen species (ROS) are major exacerbation factor in acute ischemic stroke, and thrombolytic agent tissue plasminogen activator (tPA) may worsen motor function and cerebral infarcts. The platinum nanoparticle (nPt) is a novel ROS scavenger, and thus we examined the clinical and neuroprotective effects of nPt in ischemic mouse brains. Mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 60 min and divided into the following four groups by intravenous administration upon reperfusion, vehicle, tPA, tPA + nPt, and nPt. At 48 h after tMCAO, motor function, infarct volume, immunohistochemical analyses of neurovascular unit (NVU), in vivo imaging of matrix metalloproteinase (MMP), and zymography for MMP-9 activity were examined. Superoxide anion generation at 2 h after tMCAO was also examined with hydroethidine (HEt). As a result, administration of tPA deteriorated the motor function and infarct volume as compared to vehicle. In vivo optical imaging of MMP showed strong fluorescent signals in affected regions of tMCAO groups. Immunohistochemical analyses revealed that tMCAO resulted in a minimal decrease of NAGO and occludin, but a great decrease of collagen IV and a remarkable increase of MMP-9. HEt stain showed increased ROS generation by tMCAO. All these results became pronounced with tPA administration, and were greatly reduced by nPt. The present study demonstrates that nPt treatment ameliorates neurological function and brain damage in acute cerebral infarction with neuroprotective effect on NVU and inactivation of MMP-9. The strong reduction of ROS production by nPt could account for these remarkable neurological and neuroprotective effects against ischemic stroke. en-copyright= kn-copyright= en-aut-name=TakamiyaM. en-aut-sei=Takamiya en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyamotoY. en-aut-sei=Miyamoto en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaT. en-aut-sei=Yamashita en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DeguchiK. en-aut-sei=Deguchi en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OhtaY. en-aut-sei=Ohta en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AbeK. en-aut-sei=Abe en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=2 en-affil= kn-affil=Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil= en-keyword=platinum nanoparticle kn-keyword=platinum nanoparticle en-keyword=cerebral ischemia kn-keyword=cerebral ischemia en-keyword=free radical scavenger kn-keyword=free radical scavenger en-keyword=neuroprotection kn-keyword=neuroprotection en-keyword=matrix metalloproteinase-9 kn-keyword=matrix metalloproteinase-9 en-keyword=tissue plasminogen activator kn-keyword=tissue plasminogen activator END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=8 article-no= start-page=1107 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101116 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo imaging of autophagy in a mouse stroke model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 light chain 3 (LC3) transgenic (Tg) mice, in vivo imaging of autophagy was performed at 1, 3 and 6 d after 60 min transient middle cerebral artery occlusion (tMCAO). Ex vivo imaging of autophagy, testing of the autophagy inhibitor 3-methyladenine (3-MA), estern blot analysis, immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) and fluorescent analyses were performed on brain sections following tMCAO. In vivo fluorescent signals were detected above the ischemic hemisphere through the skull bone at 1, 3 and 6 d after tMCAO, with a peak at 1 d. Similar results were obtained with ex vivo fluorescence imaging. western blot analysis revealed maximum LC3-I and LC3-II expression at 1 d after tMCAO and fluorescence immunohistochemistry demonstrated that GFP-LC3-positive cells were primarily neuronal, not astroglial or microglial, cells. The number of GFP-LC3/TUNEL double-positive cells was greater in the peri-ischemic area than in the core. These results provided evidence of in vivo autophagy detection, with a peak at 1 d, in a live animal model following cerebral ischemia. This novel technique could be valuable for monitoring autophagic processes in vivo in live stroke patients, as well as for clarifying the detailed role of autophagy in the ischemic brain, as well as in other neurological diseases. en-copyright= kn-copyright= en-aut-name=TianFengFeng en-aut-sei=Tian en-aut-mei=FengFeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MorimotoNobutoshi en-aut-sei=Morimoto en-aut-mei=Nobutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhangXuemei en-aut-sei=Zhang en-aut-mei=Xuemei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=LiuNing en-aut-sei=Liu en-aut-mei=Ning kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MatsuuraTohru en-aut-sei=Matsuura en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=8 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=9 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=10 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci affil-num=11 en-affil= kn-affil=Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci en-keyword=autophagy kn-keyword=autophagy en-keyword=apoptosis kn-keyword=apoptosis en-keyword=GFP-LC3 Tg mice kn-keyword=GFP-LC3 Tg mice en-keyword=in vivo imaging kn-keyword=in vivo imaging en-keyword=tMCAO kn-keyword=tMCAO END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=69 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for the treatment of ParkinsonБfs disease kn-title=ГpБ[ГLГУГ\ГУХaВ╠ОбЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name=СqУcТqОq kn-aut-sei=СqУc kn-aut-mei=ТqОq aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@Р_МoУрЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=83 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Complications of hand-foot-mouth disease kn-title=ОшСлМ√ХaВ╠НЗХ╣П╟ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamashitaNobuko en-aut-sei=Yamashita en-aut-mei=Nobuko kn-aut-name=ОRЙ║РMОq kn-aut-sei=ОRЙ║ kn-aut-mei=РMОq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ХaМ┤ГEГCГЛГXКw END start-ver=1.4 cd-journal=joma no-vol=2005 cd-vols= no-issue=94 article-no= start-page=123 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Construction of Compositional Lexical Database Based on Lexical Conceptual Structure kn-title=ХкЧ▐В╠НкЛТВЁЦ╛ОжВ╡В╜УоОММъЬbКTФOН\СвОлПСВ╠Н\Тz en-subtitle= kn-subtitle= en-abstract=This paper presents our ongoing research for constructing a Japanese verb lexicon which is founded on the theory of lexical conceptual structure (LCS). LCS provides a framework for capturing the relation between syntactic behaviors of lexical items and their semantic properties, which is useful for a range of NLP tasks including translation, paraphrasing and summarization. We discuss design issues involved in LCS dictionary development, and present an overview of the current specification of the lexicon, which is designed to allow successive future refinements. kn-abstract=Ц{МдЛЖВ┼В═МъЬbКTФOН\СвВЁЧШЧpВ╡В╜УоОМВ╠ОлПСГfБ[Г^ГxБ[ГXВЁН\ТzВ╖ВщБDМъЬbКTФOН\СвВ═Н\Х╢ПуВ┼В╠МъВ╠РUВщХСВвВЁКюВ╔И╙ЦбН\СвВЁЛLПqВ╖ВщВрВ╠В┼БCВ▒ВдВ╡В╜ОлПСГfБ[Г^В═М╛МъПИЧЭВ╔ВиВвВ─У┴В╔М╛МъР╢РмБCЧсВжВ╬Ц|ЦєВтМ╛ВвК╖ВжБCЧvЦёВ╞ВвВ┴В╜ЙЮЧpВ╔ХKР{В╞В╚ВщМ╛МъОСМ╣В┼ВаВщБDТёИ─В╖ВщОлПСГfБ[Г^В═МъЬbКTФOН\СвВ╠В▌ВЁЛLПqВ╖ВщВ╠В┼В═В╚ВнБCМъЬbКTФOН\СвВ╠ХкР═В┼Ц╛ВчВйВ╔В╖ВщМъВ╠РUВщХСВвБCВ╚ВчВ╤В╔ХкР═В╠КюВ╞В╚ВщУЭМъГeГXГgВЁЛLПqВ╖ВщВ╜В▀БCХкЧ▐НкЛТВкВэВйВшВтВ╖ВнУзЦ╛РлВ╠НВВвОлПСГfБ[Г^В╞В╚ВщВ▒В╞ВкК·С╥В┼ВлВщБD en-copyright= kn-copyright= en-aut-name=TakeuchiKoichi en-aut-sei=Takeuchi en-aut-mei=Koichi kn-aut-name=Т|УрНEИъ kn-aut-sei=Т|Ур kn-aut-mei=НEИъ aut-affil-num=1 ORCID= en-aut-name=InuiKentaro en-aut-sei=Inui en-aut-mei=Kentaro kn-aut-name=КгМТС╛ШY kn-aut-sei=Кг kn-aut-mei=МТС╛ШY aut-affil-num=2 ORCID= en-aut-name=FujitaAtsushi en-aut-sei=Fujita en-aut-mei=Atsushi kn-aut-name=УбУcУ─ kn-aut-sei=УбУc kn-aut-mei=У─ aut-affil-num=3 ORCID= en-aut-name=TakeuchiNao en-aut-sei=Takeuchi en-aut-mei=Nao kn-aut-name=Т|УрУ▐ЙЫ kn-aut-sei=Т|Ур kn-aut-mei=У▐ЙЫ aut-affil-num=4 ORCID= en-aut-name=AbeShuya en-aut-sei=Abe en-aut-mei=Shuya kn-aut-name=ИвХФПCЦч kn-aut-sei=ИвХФ kn-aut-mei=ПCЦч aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ affil-num=2 en-affil= kn-affil=У▐Ч╟РцТ[Й╚КwЛZПpСхКwЙ@СхКw affil-num=3 en-affil= kn-affil=ЛЮУsСхКwПюХёКwМдЛЖЙ╚ affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil=У▐Ч╟РцТ[Й╚КwЛZПpСхКwЙ@СхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ГLГEГCГtГЛБ[ГcЙ╩О└В╔ВиВпВщНRУЬФAХaНьЧpВ╞НRО_Й╗Ф\В╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeDaigo en-aut-sei=Abe en-aut-mei=Daigo kn-aut-name=ИвХФСхМс kn-aut-sei=ИвХФ kn-aut-mei=СхМс aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=227 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment and care of intractable neurological diseases kn-title=Р_МoУрЙ╚Ч╠ИцВ╠УяОбРлО╛К│РfЧ├ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name=ТrУcЙ└Р╢ kn-aut-sei=ТrУc kn-aut-mei=Й└Р╢ aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw en-keyword=Р_МoУяХa kn-keyword=Р_МoУяХa en-keyword=ГAГЛГcГnГCГ}Б[Хa kn-keyword=ГAГЛГcГnГCГ}Б[Хa en-keyword=ГpБ[ГLГУГ\ГУХaК╓ШAО╛К│ kn-keyword=ГpБ[ГLГУГ\ГУХaК╓ШAО╛К│ en-keyword=Р╥РСПмФ]Х╧РлП╟БEС╜МnУЭИ▐ПkП╟ kn-keyword=Р╥РСПмФ]Х╧РлП╟БEС╜МnУЭИ▐ПkП╟ en-keyword=Л╪И▐ПkРлСдНїНdЙ╗П╟ kn-keyword=Л╪И▐ПkРлСдНїНdЙ╗П╟ END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=13 article-no= start-page=2097 end-page=2103 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090918 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mechanical stretch stimulates integrin Г┐VГ└3-mediated collagen expression in human anterior cruciate ligament cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Biomechanical stimuli have fundamental roles in the maintenance and remodeling of ligaments including collagen gene expressions. Mechanical stretching signals are mainly transduced by cell adhesion molecules such as integrins. However, the relationships between stress-induced collagen expressions and integrin-mediated cellular behaviors are still unclear in anterior cruciate ligament cells. Here, we focused on the stretch-related responses of different cells derived from the ligament-to-bone interface and midsubstance regions of human anterior cruciate ligaments. Chondroblastic interface cells easily lost their potential to produce collagen genes in non-stretched conditions, rather than fibroblastic midsubstance cells. Uni-axial mechanical stretches increased the type I collagen gene expression of interface and midsubstance cells up to 14- and 6-fold levels of each non-stretched control, respectively. Mechanical stretches also activated the stress fiber formation by shifting the distribution of integrin Г┐VГ└3 to the peripheral edges in both interface and midsubstance cells. In addition, integrin Г┐VГ└3 colocalized with phosphorylated focal adhesion kinase in stretched cells. Functional blocking analyses using anti-integrin antibodies revealed that the stretch-activated collagen gene expressions on fibronectin were dependent on integrin Г┐VГ└3-mediated cellular adhesions in the interface and midsubstance cells. These findings suggest that the integrin Г┐VГ└3-mediated stretch signal transduction might have a key role to stimulate collagen gene expression in human anterior cruciate ligament, especially in the ligament-to-bone interface. en-copyright= kn-copyright= en-aut-name=TetsunagaTomonori en-aut-sei=Tetsunaga en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FurumatsuTakayuki en-aut-sei=Furumatsu en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Cardiovascular Physiology, Biophysiological Sciences, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cardiovascular Physiology, Biophysiological Sciences, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=Anterior cruciateligament kn-keyword=Anterior cruciateligament en-keyword=Collagen kn-keyword=Collagen en-keyword=Integrin Г┐VГ└3 kn-keyword=Integrin Г┐VГ└3 en-keyword=Interface kn-keyword=Interface en-keyword=Mechanical stretch kn-keyword=Mechanical stretch END start-ver=1.4 cd-journal=joma no-vol=402 cd-vols= no-issue=2 article-no= start-page=329 end-page=334 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury en-subtitle= kn-subtitle= en-abstract= kn-abstract=Basic fibroblast growth factor (bFGF) and growth and differentiation factor (GDF)-5 stimulate the healing of medial collateral ligament (MCL) injury. However, the effect of isolated and combined use of bFGF/GDF-5 remains still unclear. We investigated cellular proliferation and migration responding to bFGF/GDF-5 using rabbit MCL fibroblasts. Rabbit MCL injury was treated by bFGF and/or GDF-5 with peptide hydrogels. Gene expression and deposition of collagens in healing tissues were evaluated. bFGF/GDF-5 treatment additively enhanced cell proliferation and migration. bFGF/GDF-5 hydrogels stimulated Col1a1 expression without increasing Col3a1 expression. Combined use of bFGF/GDF-5 stimulated type I collagen deposition and the reorganization of fiber alignment, and induced better morphology of fibroblasts in healing MCLs. Our study indicates that combined use of bFGF/GDF-5 might enhance MCL healing by increasing proliferation and migration of MCL fibroblasts, and by regulating collagen synthesis and connective fiber alignment. en-copyright= kn-copyright= en-aut-name=SaigaKenta en-aut-sei=Saiga en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FurumatsuTakayuki en-aut-sei=Furumatsu en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshidaAki en-aut-sei=Yoshida en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MasudaShin en-aut-sei=Masuda en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakihiraShota en-aut-sei=Takihira en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Intelligent Orthopaedic System Development, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=Medial collateral ligament kn-keyword=Medial collateral ligament en-keyword=bFGF kn-keyword=bFGF en-keyword=GDF-5 kn-keyword=GDF-5 en-keyword=Hydrogel scaffold kn-keyword=Hydrogel scaffold en-keyword=Ligament healing kn-keyword=Ligament healing END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=4 article-no= start-page=219 end-page=223 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic Approaches to Vascular Protection in Ischemic Stroke en-subtitle= kn-subtitle= en-abstract= kn-abstract=Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=cerebral ischemia kn-keyword=cerebral ischemia en-keyword=hemorrhagic transformation kn-keyword=hemorrhagic transformation en-keyword=activator kn-keyword=activator en-keyword=free radical kn-keyword=free radical en-keyword=matrix metalloproteinase-9 kn-keyword=matrix metalloproteinase-9 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=141 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Japanese guideline for management of lateral epicondylitis kn-title=ПуШrНЬКOСдПушўЙКВ╠РfЧ├ГKГCГhГЙГCГУ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimamuraYasunori en-aut-sei=Shimamura en-aut-mei=Yasunori kn-aut-name=УЗС║И└Се kn-aut-sei=УЗС║ kn-aut-mei=И└Се aut-affil-num=1 ORCID= en-aut-name=InoueMadoka en-aut-sei=Inoue en-aut-mei=Madoka kn-aut-name=ИфПуЙ~Й┴ kn-aut-sei=ИфПу kn-aut-mei=Й~Й┴ aut-affil-num=2 ORCID= en-aut-name=OzawaMasatugu en-aut-sei=Ozawa en-aut-mei=Masatugu kn-aut-name=ПмрVР│Оk kn-aut-sei=ПмрV kn-aut-mei=Р│Оk aut-affil-num=3 ORCID= en-aut-name=KanazawaTomoko en-aut-sei=Kanazawa en-aut-mei=Tomoko kn-aut-name=ЛррVТqОq kn-aut-sei=ЛррV kn-aut-mei=ТqОq aut-affil-num=4 ORCID= en-aut-name=SaitouTaiichi en-aut-sei=Saitou en-aut-mei=Taiichi kn-aut-name=Н╓УбС╛Иъ kn-aut-sei=Н╓Уб kn-aut-mei=С╛Иъ aut-affil-num=5 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name=ТЖМ┤Ч┤Иъ kn-aut-sei=ТЖМ┤ kn-aut-mei=Ч┤Иъ aut-affil-num=6 ORCID= en-aut-name=NodaTomoyuki en-aut-sei=Noda en-aut-mei=Tomoyuki kn-aut-name=ЦьУcТmФV kn-aut-sei=ЦьУc kn-aut-mei=ТmФV aut-affil-num=7 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name=Р╝УcМ\ИъШY kn-aut-sei=Р╝Уc kn-aut-mei=М\ИъШY aut-affil-num=8 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=ФЎ·▒ХqХ╢ kn-aut-sei=ФЎ·▒ kn-aut-mei=ХqХ╢ aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=3 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=4 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=5 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=6 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=7 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=8 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ affil-num=9 en-affil= kn-affil=ЙкОRСхКwХaЙ@Б@РоМ`КOЙ╚ END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue= article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Migration limited in fresh water and adaptation to flood area of kissing loach - Ecological study of kissing loach in Yoshii River system, Okayama - kn-title=ГAГЖГВГhГLВ╠БgТWРЕЙёЧVБhВ╞Ф├ЧФМ┤К┬ЛлВ╓В╠УKЙЮБ`ЛgИфРьРЕМnВ╔ВиВпВщР╢С╘КwУIМдЛЖБ` en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeTsukasa en-aut-sei=Abe en-aut-mei=Tsukasa kn-aut-name=ИвХФОi kn-aut-sei=ИвХФ kn-aut-mei=Оi aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚ЛНСЛЧ╒КCО└М▒ПК END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=11 article-no= start-page=2323 end-page=2333 dt-received= dt-revised= dt-accepted= dt-pub-year=1937 dt-pub=19371130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the results of heterovaccination against typhoid, as enforced in Okayama Prefecture kn-title=ЙкОRуpЙ║ГjЙЧГPГЛТ░Г`ГtГXШмЦhГjЫФГXГЛИ┘ОэЛ█уSМ√Ц╞ЙuЫЙО{РмР╤ГjПAГe en-subtitle= kn-subtitle= en-abstract= kn-abstract=S. Murakami, Y. Miki, and F. Miyagawa proved that there is a remarkable output of heteroantibody against typhoid, paratyphoid A and B, and dysentery bacilli in the animal experiment, they proceeded in 1934 to experiment with cocktyphoid-bacilli which had been obtained from cocks that had died of cocktyphoid. They were also highly successful in bringing about a state of immunity from typhoid when applying the same bacilli to rabbits. We therefore resolved to use it upon human beings, and put it into practice, per os, with 9252 peoples in all, in April, 1936. Those treated were ordinary citizens and factory-hands. As to the result, we knew that we might disregard such by-effect of the vaccinationstomach-ache, headache, diarrhoea, etc. -as we found in a mild form. When, at the end of the November of the same year, we investigated the cases of 7486 of those who had been thus vaccinated whit a view to ascertaining if there had been any outbreak of typhoid, paratyphoid A and B, or dysentery (for we cousidered that the vaccine has some influence on the latter disease also), we found among the workmen-class no outbreak of the above-mentioned diseases in the case of those who had taken the cocktyphoid-vaccine, while there were 2 dysentery patients among those who had taken Heterogen. In the case of the ordinary citizens there had occurred one typhoid and one dysentery case among those who had taken bile and the cocktyphoid-vaccine. The number of victims was, moreover, far less than among those who had not been vaccinated. What is more, the patients made very good progress. Thus we believe that the cocktyphoid-vaccine may be successfully applied orally to the human body. As for its effect upon dysentery, we consider that this should be made the subject of further study in the future. en-copyright= kn-copyright= en-aut-name=ShimizuM. en-aut-sei=Shimizu en-aut-mei=M. kn-aut-name=Р┤РЕМїОб kn-aut-sei=Р┤РЕ kn-aut-mei=МїОб aut-affil-num=1 ORCID= en-aut-name=MikiY. en-aut-sei=Miki en-aut-mei=Y. kn-aut-name=ОOЦ╪НsОб kn-aut-sei=ОOЦ╪ kn-aut-mei=НsОб aut-affil-num=2 ORCID= en-aut-name=AsanumaK. en-aut-sei=Asanuma en-aut-mei=K. kn-aut-name=Я╟П└Р┤Оu kn-aut-sei=Я╟П└ kn-aut-mei=Р┤Оu aut-affil-num=3 ORCID= en-aut-name=AbeK. en-aut-sei=Abe en-aut-mei=K. kn-aut-name=ИвХФНВТm kn-aut-sei=ИвХФ kn-aut-mei=НВТm aut-affil-num=4 ORCID= en-aut-name=MiyagawaF. en-aut-sei=Miyagawa en-aut-mei=F. kn-aut-name=Л{РьХ╢ЧY kn-aut-sei=Л{Рь kn-aut-mei=Х╢ЧY aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=2 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=3 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=4 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=5 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=635 end-page=642 dt-received= dt-revised= dt-accepted= dt-pub-year=1937 dt-pub=19370331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=About the Epidemic of a Kind of Feveric Jaundice occurred in some Parts of Okayama City during the later Summer 1935 kn-title=П║Шa10ФNФ╙Й─ЙкОRОsТnХ√ГjЧмНsГVГ^ГЛБ[ФMРлЙйсtХaГjПAГe en-subtitle= kn-subtitle= en-abstract= kn-abstract=There occurred an epidemic of a kind of feveric jaundice in some parts of Okayama City and its vicinity from the later part of Summer till early autumn 1935. As we had never learned such an outbreak of such an epidemic in these districts, we wished to make it clear. We have studied it under the guidance of Prof. M. Suzuki and our study as a whole resulted as follows: 1) To our regret, we could not succeed in isolating the causal agent. This may be we think, for when we set about the study, the epidemic had already come to its closing period. 2) The clinical symptoms of this disease, we observed, were quite identical with those of the Sakushu fever. 3) And as the serological tests we examined the Pfeiffers phenomenon test and the agglomeration reaction on 12 cases and obtained: 7 positive reaction with Akiyami repto. type A. 3 positive reaction with Akiyami repto. type B. these 10 negative reaction with repto. ict. haemorrha. and the rest 2 of 12 cases gave negative reaction with any of these reptospiras. 4) We cannot yet dare to describe clearly from the epidemiological point of view why such a prevalence of this disease broke out in 1935, but it might be regarded as remarkable facts to indicate some relationship between the great inundation and the epidemic that the infected locality was visited by a disastrous inundation in the preceding year, that the upper course district of the flooded river Asahi was known as the region influenced by the Sakushu fever, and that the infected parts of Okayama City borders the suburbs where a great number of the rats, regarded as the mediators of the Sakushu fever are living, etc. You will have still more reports after our further study in the future. en-copyright= kn-copyright= en-aut-name=MurakamiS. en-aut-sei=Murakami en-aut-mei=S. kn-aut-name=С║ПуЮ─ kn-aut-sei=С║Пу kn-aut-mei=Ю─ aut-affil-num=1 ORCID= en-aut-name=MikiY. en-aut-sei=Miki en-aut-mei=Y. kn-aut-name=ОOЦ╪НsОб kn-aut-sei=ОOЦ╪ kn-aut-mei=НsОб aut-affil-num=2 ORCID= en-aut-name=AbeT. en-aut-sei=Abe en-aut-mei=T. kn-aut-name=ИвХФНВТm kn-aut-sei=ИвХФ kn-aut-mei=НВТm aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=2 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ affil-num=3 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=53 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Guidelines for anterior cruciate ligament injury kn-title=ХGСOП\ОЪРxС╤С╣ПЭ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name=ИвХФРMК░ kn-aut-sei=ИвХФ kn-aut-mei=РMК░ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Й^УоКэТmФ\Й╗ГVГXГeГАКJФн END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=6 article-no= start-page=1206 end-page=1219 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Die Untersuchungen ?ber die enzystierten Zerkarien von Trematoden in Rhodeus lanceolata (II. Teil) ?ber die Arten und Infektionskoeffizienten der enzystierten Zerkarien von Trematoden an vershiedenen K?rperpartien des Rhodeus lanceolata kn-title=Rhodeus lanceolataГjКёР╢ГXГЛЛzх│Ч▐ФэФXЧcх│ГmМдЛЖБiСц2Х╥БjRhodeus lanceolataГjКёР╢ГXГЛЛzх│Ч▐ФэФXЧcх│ГmОэЧ▐тНГjС┤ГmХФИ╩Х╩КёР╢ЧжГjПAГe en-subtitle= kn-subtitle= en-abstract= kn-abstract=Von 1934 an hat Verfasser auf Anraten von Prof. M. Suzuki. die Untersuchungen ?ber enzystierten Zerkarien von Trematoden in Rhodeus lanceolata in Provinz Okayama durchgef?hrt und konnte die oben genannte Untersuchung nachforschen. Die Arten der Metazerkarien wurden folgenderweise eingeteilt, d.h. 1) Sog. Hasegawa'sche neue Art von Stammnosoma, 2) Stammnosoma armatum, 3) Exorchis oviformis, 4) Clonorchis sinensis, 5) Metagonimus takahashii, 6) Echinochasmus japonicus, 7) Cyatocotyle b Hasegawa, 8) Exorchis (Pseudexorchis) major, 9) Echinochasmus perfoliatus, 10) Sog. Hasegawa'sches unklares Distomum c, 11) Sog. Hasegawa'sches unklares Distomum a, 12) Cyatocotyle c Hasegawa, 13) Sog. Hasegawa'sches unklares Distomum b, 14) Cyatocotyle a Hasegawa, 15) Asymphylodora tincae. Von denen fand Verfasser 9 neuartige Metazerkarien in diesen Fischen, die in der obenstehenden Einteilung als 5), 8), 10), 11), 12), 13), 14), 15) geschrieben wurden. In Rhodeus lanceolata gibt es nach der Literatur noch 7 andere Arten der Metazerkarien und so konnte Verfasser darauf finden, das die in Rhodeus lanceolata enzystierten Zerkarien. insgesammt nicht so geringer als die in Pseudorasbora parva sind, denen Arten im Allgemeinen bis her als die zahlreichste gewusst waren. ?ber die Dichtheit von Metazerkarien hat Verfasser die Ordnung der Infektionskooffizienten von jeder Art und K?rpespartien der Fischen, also hat Verfasser gefunden, dass Rhodeus lanceolata der Hauptzwischenwirt von Stammnosoma Arten ist. Die Metazerkarienzahl von Clonorchis sinensis war auch m?ssig gross. Die Metazerkarienzahl von Clonorchis sinensis war auch m?ssig gross. Aus diesem Grund der Verfasser ?berzeugt davon, dass Rhodeus lanceolata die wichtigste Art von S?sswasserfischen nicht nur aus profilaktischem Standpunkt, sondern auch als das Material der Studierung von Trematoden ist. en-copyright= kn-copyright= en-aut-name=AbeTakatomo en-aut-sei=Abe en-aut-mei=Takatomo kn-aut-name=ИвХФНВТm kn-aut-sei=ИвХФ kn-aut-mei=НВТm aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=5 article-no= start-page=956 end-page=1038 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Die Untersuchungen ?ber die enzystierten Zerkarien von Trematoden in Rhodeus lauceolata (I. Teil) ?ber die jahrzeitlichen Ver?ndrungen der enzystierten Zerkarien von Trematoden in Rhodeus lanceolata kn-title=Rhodeus lanceolataГjКёР╢ГXГЛЛzх│Ч▐ФэФXЧcх│ГmМдЛЖБiСц1Х╥БjRhodeus lanceolataГjКёР╢ГXГЛЛzх│Ч▐ФэФXЧcх│ГmЛGР▀УIП┴Т╖ГjПAГe en-subtitle= kn-subtitle= en-abstract= kn-abstract=Auf Antrafen von Dr. M. Suzuki bat Verfasser seit 1934 die Untersuchungen u?ber enzystierten Zerkarien von Trematoden in Rhodeus lanceolata in Provinz Okayama durchgef?hrt und von 5, Januar 1936 bis 20 Dezember 1936 hat Verfasser ein ganzes Jahr hindurch die oben gannante Untersuchung auch unter der Freundlichsten Leitung von Dr. M. Suzuki nachgeforscht. Die Gesammtzahl von Rhodeus lanceolata krumeus und R. 1. moriokae, die Verfasser im Flues f?r Bew?sserung der Reisfelder im Okita-son, Jodo-gun, Okayama-ken, zwei- oder dreimal monatlich und jedesmal je 10 Fische (jeder Fisch etw. 5,75-3,2cm lang) ansammelten, betr?gt 250. Jeder Fisch wurde, in 9 Partien verteilt, untersucht -d. h. Kopfeteil, Muskel am Rumpf, Kiemen und Kiemenplatte, Sch?ppen, R?ckenflosse, Brustflossen, Bauchflossen, Ges?ssflossen und Schwanzflosse. Die drei Ersten wurden mit die vom Verfasser modifizierten K?nstlichen Magensaft (Pepsin 0,3. HCl 0,4, Aq. dest. 100,0) verdant und dann untersucht, aber die anderen Partien wurden roh untersucht. Die Ergebnisse dieser Untersuchung wurden folgenderweise zusammengefasst. 1) In 250 Rhodeus lanceolata wurden sammt 54796 Metazerkarien aufgefunden, die in 14 folgenden Arten eingeteilt wurden, d.h. 1. Sog. Hasegawa'sche neue Art von Stammnosma. 2. Stanunuosoma armatum. 3. Exorchis oviformis. 4. Exorchis (Pseudexorchis) major. 5. Clonorchis sinensis. 6. Metagonimus takahashii. 7. Echinochasmus japonicus. 8. Echinochasmus perfoliatus. 9. sog. Hasegawa'sches unklares Distomum a. 10. Sog. Hasegawa'sches unklares Distomum b. 11. Sog. Hasegawa'sches unklares Distomum c. 12. Cyatocotyle b Hasegawa. 13. Cyatocotyle c Hasegawa. 14. Asymphylodora tincae. Die Infektionsk?ffizienten waren im Allgemeinen kleiner zwischen Januar und Juni, w?hrend vom Juli bis Oktober sehr gross, besonders im September am gr?ssten, und dann wieder kleiner in den nachfolgenden 2 Monaten. ?ber das Sterblichkeitsverh?ltnis von Metazerkarien fand der Verfasser- am kleinsten in der Mitte des Septembers und am grossten in 2 Monaten vom Ende Oktober bis Dezember. Die neu entwickelten Metazerkarien werden meist zwischen Juli und August gefun-den. 2) Jede art zeigt ihre jahrzeittiche Schwankungen von Infektionskoeffizfent der Metazerkarien, insbesonders die der Stammosoma Arten, so wie die Sterblichkeit, sehr eigent?mlich ist, n?mlich ihren lebenden Metazerkarien vermehren ganz pl?tzlich im August und September (am gr?ssten im Ende September) und dann wieder schnell vermindern, w?hrend die Zahl der gestorbenen Metazerkarien ausserordentlich gross fast ein ganzes Jahr hindurch, besonders kurz vor und nach der Vermehrung der lebenden Metazerkarien sind. 3) Der Infektionskoeffizient von Clonorchis sinensis ist gross zwischen dem Ende August und Oktober, sondern dagegen klein in den nachfolgenden 2 Monaten und vom Januar bis Juli. 4) Die ?brigen Arten zeigen nicht so starken Schwankungen, aber auch vermehren meist im Sommern, und vermindern im Winter. 5) Es ist weiter erschlossen worden, dass f?r jahrzeitliche Schwankungen von Infektionskoeffizient der Metazerkarien die Sonnenlichtstrahlung und Wassertemperatur die gross Rolle spielt haben. en-copyright= kn-copyright= en-aut-name=AbeTakatomo en-aut-sei=Abe en-aut-mei=Takatomo kn-aut-name=ИвХФНВТm kn-aut-sei=ИвХФ kn-aut-mei=НВТm aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRч╬Й╚СхЫ{Н╫Л█Ы{Л│О║ END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=195 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain kn-title=ГЙГbГgПoММРлН[Н╟ГВГfГЛВ╔ВиВпВщГGГ_ГЙГ{ГУВ╠neurovascular unitХ█МьМ°Й╩ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name=ОRЙ║УO kn-aut-sei=ОRЙ║ kn-aut-mei=УO aut-affil-num=1 ORCID= en-aut-name=KamiyaTatsushi en-aut-sei=Kamiya en-aut-mei=Tatsushi kn-aut-name=Р_ТJТBОi kn-aut-sei=Р_ТJ kn-aut-mei=ТBОi aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name=ПoМ√МТС╛ШY kn-aut-sei=ПoМ√ kn-aut-mei=МТС╛ШY aut-affil-num=3 ORCID= en-aut-name=InabaToshiki en-aut-sei=Inaba en-aut-mei=Toshiki kn-aut-name=ИюЧtПrУМ kn-aut-sei=ИюЧt kn-aut-mei=ПrУМ aut-affil-num=4 ORCID= en-aut-name=ZhangHanzhe en-aut-sei=Zhang en-aut-mei=Hanzhe kn-aut-name=ТгК┐УN kn-aut-sei=Тг kn-aut-mei=К┐УN aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name=ПдМhИ╠ kn-aut-sei=Пд kn-aut-mei=МhИ╠ aut-affil-num=6 ORCID= en-aut-name=MiyazakiKazunori en-aut-sei=Miyazaki en-aut-mei=Kazunori kn-aut-name=Л{НшИъУ┐ kn-aut-sei=Л{Нш kn-aut-mei=ИъУ┐ aut-affil-num=7 ORCID= en-aut-name=OhtsukaAiji en-aut-sei=Ohtsuka en-aut-mei=Aiji kn-aut-name=СхТ╦ИдУё kn-aut-sei=СхТ╦ kn-aut-mei=ИдУё aut-affil-num=8 ORCID= en-aut-name=KatayamaYasuo en-aut-sei=Katayama en-aut-mei=Yasuo kn-aut-name=Х╨ОRС╫ШN kn-aut-sei=Х╨ОR kn-aut-mei=С╫ШN aut-affil-num=9 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=3 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=4 en-affil= kn-affil=У·Ц{ИуЙ╚СхКwБ@СцУёУрЙ╚ affil-num=5 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=6 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=7 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw affil-num=8 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@РlС╠Н\РмКw affil-num=9 en-affil= kn-affil=У·Ц{ИуЙ╚СхКwБ@СцУёУрЙ╚ affil-num=10 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@Ф]Р_МoУрЙ╚Кw en-keyword=ПoММРлН[Н╟ (hemorrhagic transformation) kn-keyword=ПoММРлН[Н╟ (hemorrhagic transformation) en-keyword=tPA (tissue plasminogen activator) kn-keyword=tPA (tissue plasminogen activator) en-keyword=MMP-9 (matrix metalloproteinase-9) kn-keyword=MMP-9 (matrix metalloproteinase-9) en-keyword=ГtГКБ[ГЙГWГJГЛ (free radical) kn-keyword=ГtГКБ[ГЙГWГJГЛ (free radical) en-keyword=ГGГ_ГЙГ{ГУ (edaravone) kn-keyword=ГGГ_ГЙГ{ГУ (edaravone) END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960229 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Т├УЗЙкСхИтР╒ 7Б@Б\Сц11ОЯТ▓Н╕Б\Б@БiСННЗПюХёПИЧЭГZГУГ^Б[РVЙcЧ\ТшТnБj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЦFШY kn-aut-sei=ИвХФ kn-aut-mei=ЦFШY aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ХxК~НFОu kn-aut-sei=ХxК~ kn-aut-mei=НFОu aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Т├УЗЙкСхИтР╒ 5Б@Б\Сц8ОЯТ▓Н╕Б\Б@БiИтУ`ОqО└М▒О{Р▌БEНЗХ╣ПИЧЭСЕРVЙcЧ\ТшТnБj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ХxК~НFОu kn-aut-sei=ХxК~ kn-aut-mei=НFОu aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ОRЦ{ЙxРв kn-aut-sei=ОRЦ{ kn-aut-mei=ЙxРв aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЦFШY kn-aut-sei=ИвХФ kn-aut-mei=ЦFШY aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Т├УЗЙкСхИтР╒ 4Б@Б\Сц5ОЯТ▓Н╕Б\Б@БiСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚УПРVЙcЧ\ТшТnБj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЦFШY kn-aut-sei=ИвХФ kn-aut-mei=ЦFШY aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ОRЦ{ЙxРв kn-aut-sei=ОRЦ{ kn-aut-mei=ЙxРв aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ХxК~НFОu kn-aut-sei=ХxК~ kn-aut-mei=НFОu aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Й═Р╝Кw kn-aut-sei=Й═Р╝ kn-aut-mei=Кw aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=УбМ┤НGОu kn-aut-sei=УбМ┤ kn-aut-mei=НGОu aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=П╝ТJЛ┼Оq kn-aut-sei=П╝ТJ kn-aut-mei=Л┼Оq aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ЙлЧzОq kn-aut-sei=Йл kn-aut-mei=ЧzОq aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Л┤Ц{ЧYИъ kn-aut-sei=Л┤Ц{ kn-aut-mei=ЧYИъ aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil= kn-affil= affil-num=8 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=1 article-no= start-page=45 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhancement of norepinephrine-induced transient contraction in aortic smooth muscle of diabetic mice. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.

en-copyright= kn-copyright= en-aut-name=AbeAsaki en-aut-sei=Abe en-aut-mei=Asaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawasoeChiaki en-aut-sei=Kawasoe en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KondoYasuhiro en-aut-sei=Kondo en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoKatsunori en-aut-sei=Sato en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=diabetes mellitus kn-keyword=diabetes mellitus en-keyword=vascular smooth muscle kn-keyword=vascular smooth muscle en-keyword=norepinephrine kn-keyword=norepinephrine END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page=25 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reduction of ischemic damage by application of insulin-like growth factor-1 in rat brain after transient ischemia. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In order to investigate a possible effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the middle cerebral artery territory showed that Caspase-3 staining was markedly reduced in the cases with IGF-1 treatment, but 72-kDa heat shock protein staining remained almost unchanged. The present results suggest that treatment with IGF-1 exerts a significant effect on ameliorating brain injury after transient focal brain ischemia. Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level.

en-copyright= kn-copyright= en-aut-name=WangJiang Ming en-aut-sei=Wang en-aut-mei=Jiang Ming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HayashiTakeshi en-aut-sei=Hayashi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZhangWen Ri en-aut-sei=Zhang en-aut-mei=Wen Ri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LiFeng en-aut-sei=Li en-aut-mei=Feng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IwaiMasanori en-aut-sei=Iwai en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=caspase-3 kn-keyword=caspase-3 en-keyword=cerebra? ischemia kn-keyword=cerebra? ischemia en-keyword=72-KDa heat shock protein kn-keyword=72-KDa heat shock protein END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=4 article-no= start-page=211 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of Rheumatoid Arthritis Using a Scoring System Devised from Magnetic Resonance Imaging of Rheumatoid Knees en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We studied the magnetic resonance imaging (MRI) of 120 knees in 86 rheumatoid arthritis (RA) patients and of 14 unaffected knees in 12 control cases. We also developed a scoring system as a quantitative analysis method. We divided the MRI into 10 items, and classified the severity of the symptoms into 4 grades (score 0 to 3). The average total score increased according to the radiographic grade. Soft tissue lesions were clearly detected, even in the early stages of RA. Items such as synovial proliferation showed a high score even in the early stages, suggesting that it was the initial symptom of RA. The score also showed a correlation with the inflammatory signs. These results suggest that this scoring system is very sensitive and yields a good reflection of RA activity. We demonstrated that this system is simple and convenient for routine diagnostic use. We further demonstrated that it is useful for following the advancement of RA and for evaluating the response to treatment.

en-copyright= kn-copyright= en-aut-name=TakeuchiKazuhiro en-aut-sei=Takeuchi en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YokoyamaYoshiki en-aut-sei=Yokoyama en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SendaMasuo en-aut-sei=Senda en-aut-mei=Masuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtaYusuke en-aut-sei=Ota en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama Universitry affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging en-keyword=scoring system kn-keyword=scoring system en-keyword=synovial membrane kn-keyword=synovial membrane END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=3 article-no= start-page=185 end-page=191 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel magnetic resonance imaging evaluation for valgus instability of the knee caused by medial collateral ligament injury en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Instability of the knee after the medial collateral ligament (MCL) injury is usually assessed with the manual valgus stress test, even though, in recent years, it has become possible to apply magnetic resonance imaging (MRI) to the assessment of the damage of the ligament. The valgus instability of 24 patients (12 isolated injuries and 12 multiple ligament injuries) who suffered MCL injury between 1993 and 1998 was evaluated with the Hughston and Eilers classification, which involves radiographic assessment under manual valgus stress to the injured knees. We developed a novel system for classifying the degree of injury to the MCL by calculating the percentage of injured area based on MRI and investigated the relationship between this novel MRI classification and the magnitude of valgus instability by the Hughston and Eilers classification. There was a significant correlation between the 2 classifications (p=0.0006). On the other hand, the results using other MRI based classification systems, such as the Mink and Deutsch classificaiton and the Petermann classification, were not correlated with the findings by the Hughston and Eilers classification in these cases (p0.05). Since MRI is capable of assessing the injured ligament in clinical practice, this novel classification system would be useful for evaluating the stability of the knee and choosing an appropriate treatment following MCL injury.

en-copyright= kn-copyright= en-aut-name=IkumaHisanori en-aut-sei=Ikuma en-aut-mei=Hisanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UchidaYouichiro en-aut-sei=Uchida en-aut-mei=Youichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FurumatsuTakayuki en-aut-sei=Furumatsu en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraKazuo en-aut-sei=Fujiwara en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Kagawa Rosai Hospital affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Nippon Kokan Fukuyama Hospital affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=5 en-affil= kn-affil=Departments of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Departments of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Departments of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=medial collateral ligament kn-keyword=medial collateral ligament en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging en-keyword=knee instability kn-keyword=knee instability en-keyword=novel method kn-keyword=novel method END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=3 article-no= start-page=141 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR. en-copyright= kn-copyright= en-aut-name=KomiyamaTakamitsu en-aut-sei=Komiyama en-aut-mei=Takamitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YorimitsuMasanori en-aut-sei=Yorimitsu en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DoiHideyuki en-aut-sei=Doi en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyazawaShinichi en-aut-sei=Miyazawa en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KitamuraAi en-aut-sei=Kitamura en-aut-mei=Ai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaAki en-aut-sei=Yoshida en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NasuYoshihisa en-aut-sei=Nasu en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University en-keyword=spontaneous hypertensive rats kn-keyword=spontaneous hypertensive rats en-keyword=insulin like growth factor-1 kn-keyword=insulin like growth factor-1 en-keyword=vascular endothelial growth factor kn-keyword=vascular endothelial growth factor en-keyword=ossification disturbance kn-keyword=ossification disturbance en-keyword=osteonecrosis kn-keyword=osteonecrosis END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=2 article-no= start-page=111 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Femoral neck fracture following avascular necrosis of the femoral head. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

<P>Four cases of femoral neck fracture following avascular necrosis of the femoral head were studied histologically. All four patients were women who had received steroid therapy, three of them for systemic lupus erythematosus and the other for idiopathic thrombocytopenic purpura. Two types of fracture were found according to the site and the mechanism of fracture. One was at the junction between the necrotic bone and the repairing bone, and it can thus be regarded as a stress fracture. The other type of fracture commenced at the superior portion of the junction between the femoral head and neck, which was weak due to the repair reaction. The fracture line extended to the inferior cortex of the femoral neck, as often occurs in the elderly. In one patient, the femoral neck fracture was the first sign of avascular necrosis of the femoral head. </P>

en-copyright= kn-copyright= en-aut-name=UsuiMasaaki en-aut-sei=Usui en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YukihiroShigehumi en-aut-sei=Yukihiro en-aut-mei=Shigehumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University en-keyword=femoral neck fracture kn-keyword=femoral neck fracture en-keyword=avascular necrosis kn-keyword=avascular necrosis en-keyword=femoral head kn-keyword=femoral head en-keyword=mechanism kn-keyword=mechanism END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication kn-title=DNA С╣ПЭГZГУГTБ[ATMГLГiБ[Г[В╞Chk2В═ВbМ^К╠ЙКГEГCГЛГXВ╠RNAХбР╗В╔ХKЧvВ┼ВаВщ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AriumiYasuo en-aut-sei=Ariumi en-aut-mei=Yasuo kn-aut-name=ЧLКCНNЧY kn-aut-sei=ЧLКC kn-aut-mei=НNЧY aut-affil-num=1 ORCID= en-aut-name=KurokiMisao en-aut-sei=Kuroki en-aut-mei=Misao kn-aut-name=НХЦ╪Ф№Н╣ПП kn-aut-sei=НХЦ╪ kn-aut-mei=Ф№Н╣ПП aut-affil-num=2 ORCID= en-aut-name=DansakoHiromichi en-aut-sei=Dansako en-aut-mei=Hiromichi kn-aut-name=ЪгФЧН_Х√ kn-aut-sei=ЪгФЧ kn-aut-mei=Н_Х√ aut-affil-num=3 ORCID= en-aut-name=AbeKenichi en-aut-sei=Abe en-aut-mei=Kenichi kn-aut-name=ИвХФМТИъ kn-aut-sei=ИвХФ kn-aut-mei=МТИъ aut-affil-num=4 ORCID= en-aut-name=IkedaMasanori en-aut-sei=Ikeda en-aut-mei=Masanori kn-aut-name=ТrУcР│У┐ kn-aut-sei=ТrУc kn-aut-mei=Р│У┐ aut-affil-num=5 ORCID= en-aut-name=WakitaTakaji en-aut-sei=Wakita en-aut-mei=Takaji kn-aut-name=ШeУcЧ▓ОЪ kn-aut-sei=ШeУc kn-aut-mei=Ч▓ОЪ aut-affil-num=6 ORCID= en-aut-name=KatoNobuyuki en-aut-sei=Kato en-aut-mei=Nobuyuki kn-aut-name=Й┴УбРщФV kn-aut-sei=Й┴Уб kn-aut-mei=РщФV aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw affil-num=3 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw affil-num=4 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw affil-num=5 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw affil-num=6 en-affil= kn-affil=НСЧзК┤РїП╟МдЛЖПКБ@ГEГCГЛГXСцУёХФ affil-num=7 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@ОюсЗГEГCГЛГXКw en-keyword=HCV kn-keyword=HCV en-keyword=ATM kn-keyword=ATM en-keyword=Chk2 kn-keyword=Chk2 en-keyword=ПhОхИЎОq kn-keyword=ПhОхИЎОq en-keyword=DNA С╣ПЭГZГУГTБ[ kn-keyword=DNA С╣ПЭГZГУГTБ[ END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=5 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19981130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Rigid-Plastic Deformation of Inhomogeneous Material with Elliptic Inclusions Sliding along Boundary en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of the slip between the inclusion and the matrix during the plastic deformation of inhomogeneous material with elliptic inclusions is investigated. The material is assumed to be rigid-plastic. The boundary slip region is modeled by assuming lower yield stress for the thin boundary region than those of the inclusion and the matrix. The rigid-plastic finite element method is used for the numerical calculation under the plane strain condition. The effects of the aspect ratio of the inclusion, the yield stress of the boundary region, and the volume fraction of the inclusion on the deformation mode are studied. The patterns of the strain concentration and the averaged flow stress of the inhomogeneous material are also discussed. The results may be helpful for understanding creep or superplastic deformation of metals with inclusions. en-copyright= kn-copyright= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name=ИвХФХРОб kn-aut-sei=ИвХФ kn-aut-mei=ХРОб aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NamikoshiRyuji kn-aut-sei=Namikoshi kn-aut-mei=Ryuji aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NagayamaNoriyuki kn-aut-sei=Nagayama kn-aut-mei=Noriyuki aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=TakanoYasuju kn-aut-sei=Takano kn-aut-mei=Yasuju aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Mechanical Engineering and Cooperative Research Center, Okayama University affil-num=2 en-affil= kn-affil=Shikoku Instrumentation Co., Ltd. affil-num=3 en-affil= kn-affil=Industrial Technology Center of Okayama Prefecture affil-num=4 en-affil= kn-affil=Kobe Steel, Ltd. en-keyword=Plasticity kn-keyword=Plasticity en-keyword=Composite Material kn-keyword=Composite Material en-keyword=Sliding Inclusions kn-keyword=Sliding Inclusions en-keyword=Rigid-Plastic Deformation kn-keyword=Rigid-Plastic Deformation en-keyword=Finite Element Method kn-keyword=Finite Element Method END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue=3-4 article-no= start-page=11 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19720430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Experimental-Anatomical Study on the Intrathalamic Fiber Connecitons of the Posterior Ventral Nuclei in the Cat kn-title=ГlГRВ╠ОЛП░МуХаСдКjВ╠ОЛП░УрМЛНЗВ╔К╓В╖ВщО└М▒ЙЁЦUКwУIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study was undertaken to elucidate the intrathalamic fiber connections of the posterior ventral nuclei of the thalamus. Localized stereotaxic lesions were placed in various parts of these nuclei in 13 cats, and the ensuing terminal degeneration in the dorsal thalamic nuclei were studied by the Nauta and Gygax method. Within the posterior ventral nuclei, the posteromedial and posterolateral ventral nuclei are diffferentiated. The posteromedial ventral nucleus is further divided into the medial parvocellular and the lateral main parts. The posterior ventral nuclei have intrathalamic connections to the surrounding thalamic nuclei, in addition to cortical projections. Regarding the intrathalamic connections from different parts of the posterior ventral nuclei some differences in termination are noted. The medial part of the posteromedial ventral nucleus, regarded as a thalamic relay station in the gustatory paths, sends fibers profusely to the intralaminar nuclei in a wide sense, including the centre median and parafascicular nuclei, and are connected across the midline with the paracentral and lateral central nuclei and the medial part of the posteromedial ventral nucleus on the opposite side. It should be mentioned that the rhomboid and medial ventral nuclei are not only pierced by decussating fibers, but also receive terminal fiders from the medial part of the posteromedial ventral nucleus. This part sends a limited number of fibers to the lateral part of the posteromedial ventral nucleus and the other ventral nuclei, including the submedial nucleus, as well as to the dorsal medial, posterior lateral and suprageniculate nuclei, but gives off no fibers to the medial and lateral geniculate bodies or the medial and inferior pulvinar nuclei. The lateral main part of the posteromedial ventral nucleus and the posterolateral ventral nucleus are considered to be thalamic relay centers for somatic sensibility. The former sends fibers to the other ventral nuclei, viz. the posterolateral ventral, lateral ventral, medial ventral and submedial nuclei. It also gives off fibers to the intralaminar nuclei in a wide sense, the lateral part of the dorsal medial nucleus and the posterior lateral, suprageniculate and medial pulvinar nuclei, but send scarcely any fibers to the medial and lateral geniculate bodies. It sends no decussating fibers to the contralateral dorsal thalamus. The dorsolateral part of the posterolateral ventral nucleus sends fibers to the posterior lateral, inferior pulvinar, suprageniculate nuclei and the lateral geniculate body, particularly its ventral nucleus. It also gives off fibers to the lateral part of the posteromedial ventral nucleus and the lateral ventral nucleus, but sends no fibers to the medial part of the posteromedial ventral nucleus or the dorsal medial, medial pulvinar, submedial and medial ventral nuclei. In addition, it gives rise to neither decussating fibers to the contralateral side nor terminal fibers to the midline nuclei. The dorsolateral part sends only few fibers to the intralaminar nuclei in a wide sense. The ventromedial part of the posterolateral ventral nucleus sends more abundant fibers to the intralaminar nuclei in a wide sense and the posteromedial ventral, medial ventral and submedial nuclei than does the dorsolateral part, but gives off a lesser amount of fibers to the lateral geniculate body and the inferior pulvinar and lateral ventral nuclei. It sends fibers to the posterior lateral and suprageniculate nuclei, and only few fibers to the medial geniculate and dorsal medial nuclei which receive no fibers from the dorsolateral part. en-copyright= kn-copyright= en-aut-name=AbeKumashige en-aut-sei=Abe en-aut-mei=Kumashige kn-aut-name=ИвХФМFПd kn-aut-sei=ИвХФ kn-aut-mei=МFПd aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцОOЙЁЦUКwЛ│О║ END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=3 article-no= start-page=195 end-page=198 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=JPN (Japan Pancreas Society) guidelines for the management of pancreatic cancer kn-title=фXКрРfЧ├ГKГCГhГЙГCГУБ\УрЙ╚ОбЧ├В╠СНШ_В╔В┬ВвВ─Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiraoKen en-aut-sei=Hirao en-aut-mei=Ken kn-aut-name=Х╜ФЎМк kn-aut-sei=Х╜ФЎ kn-aut-mei=Мк aut-affil-num=1 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name=Й═Ц{ФОХ╢ kn-aut-sei=Й═Ц{ kn-aut-mei=ФОХ╢ aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=ОRЦ{ШaПG kn-aut-sei=ОRЦ{ kn-aut-mei=ШaПG aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@П┴Й╗КэБEК╠СЯУрЙ╚Кw affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@П┴Й╗КэБEК╠СЯУрЙ╚Кw affil-num=3 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХЦЄКwСННЗМдЛЖЙ╚Б@П┴Й╗КэБEК╠СЯУрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ЛЫЧ▐В╠ЙёЧVБEОYЧСВЁРзМфВ╖ВщЧvИЎВ╞Ф├ЧФМ┤К┬ЛлВ╓В╠УKЙЮ Б\БgПГТWРЕЙёЧVЛЫБhГAГЖГВГhГLВЁЧpВвВ╜Р╢С╘Р╢ЧЭКwУIМдЛЖБ\ kn-title=Eco-physiological studies on the migration limited in freshwater areas and spawning of kissing loach: Adaptations of teleost fishes to floodplain environments en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeTsukasa en-aut-sei=Abe en-aut-mei=Tsukasa kn-aut-name=ИвХФОi kn-aut-sei=ИвХФ kn-aut-mei=Оi aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ГvГЙГУГgРзМфОxЙЗВ╠В╜В▀В╠РlК╘ГВГfГЛВ╞ТmОпКlУ╛В╔К╓В╖ВщКюСbМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeYoshihiro en-aut-sei=Abe en-aut-mei=Yoshihiro kn-aut-name=ИвХФЙїЧm kn-aut-sei=ИвХФ kn-aut-mei=ЙїЧm aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ф|Ч{Н╫ЦEМnВ╔ВиВпВщМ°ЧжУIВ╚СSТ╖CМ^К╠ЙКГEГCГЛГXRNAХбР╗В╔ХKЧvВ╚NS3Т`ФТО┐ТЖВ╠УKЙЮХ╧И┘ kn-title=Cell culture-adaptive NS3 mutations required for the robust replication of genome-length hepatitis C virus RNA en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeKenichi en-aut-sei=Abe en-aut-mei=Kenichi kn-aut-name=ИвХФМТИъ kn-aut-sei=ИвХФ kn-aut-mei=МТИъ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=1 article-no= start-page=89 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19901214 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Structure of Interregional Migration in Japanese Regions : An Application of Multidimensional Scaling en-subtitle= kn-subtitle= en-abstract= kn-abstract=Multidimensional scaling (MDS) has been used in a wide variety of research fields; psychology, political science, anthropology, marketing research, urban and regional planning, and so on. In practical terms, MDS is a statistical method to make a picture of the information in the data. It enables us to examine the "hidden structure" of a set of data. When the set of data is large, MDS is extremely useful, since it is easier and more informative to look at a picture than the data themselves. In this paper, MDS is applied to the interregional migration data of Japanese regions for the years 1960-85. Findings show that the two-dimensional configuration of regions estimated by MDS generally corresponds with the geographical locations of regions, and the structure of interregional migration was very stable over the study years 1960-85. It is also suggested that MDS is a useful tool to identify the relationships between regions using the spatial interaction data. en-copyright= kn-copyright= en-aut-name=AbeHirofumi en-aut-sei=Abe en-aut-mei=Hirofumi kn-aut-name=ИвХФНGОj kn-aut-sei=ИвХФ kn-aut-mei=НGОj aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=OishiManabu kn-aut-sei=Oishi kn-aut-mei=Manabu aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Civil Engineering affil-num=2 en-affil= kn-affil=Japan Freight Railway Company END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=115 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19891129 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Trends in the Regional Structure of Manufacturing Industries in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=The rapid economic growth of Japan in the postwar period has brought about the over-concentration of activities in a few large cities, and local regions have been losing their economic vitality due to the regional differentials and the population loss. Regional development planning in Japan has sought to achieve a balanced growth of the nation through the development of industries in local regions. This paper aims to examine the regional structure of manufacturing industries in the postwar period and to identify its current problems. Three methods, namely the analysis of coefficient of variation, the rateshare analysis and the shift-share analysis are applied using employment data of manufacturing industries for the years 1955 to 1985. Findings show that while the employment of manufacturing industries has been markedly decentralized from metropolitan to local regions, the disparities in growth rates still exist among regions. en-copyright= kn-copyright= en-aut-name=AbeHirofumi en-aut-sei=Abe en-aut-mei=Hirofumi kn-aut-name=ИвХФНGОj kn-aut-sei=ИвХФ kn-aut-mei=НGОj aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NogataMikio kn-aut-sei=Nogata kn-aut-mei=Mikio aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Civil Engineering affil-num=2 en-affil= kn-affil=Okayama Prefectural Office END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=1 article-no= start-page=81 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19921125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of JR Seto Ohashi Line on Residential Land Value en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper aims to examine the impact of JR (Japan Railways) Seto Ohashi Line on residential land value. First, the study examines the trends in land value in the area along JR Seto Ohashi Line by applying the area comparison method. The method estimates the effect of JR Seto Ohashi Line on residential land value by comparing land values between the study area and the Okayama Metropolitan Area. Second, the property value method is applied to measure the effect of railroad construction. The effect is estimated with a residential land-value regression, which is calibrated using land value data along the Seto Ohashi Line. Finally, the results are compared with the empirical studies in the Greater Tokyo Region, and various features of the impact of railroad construction on land value are identified. en-copyright= kn-copyright= en-aut-name=AbeHirofumi en-aut-sei=Abe en-aut-mei=Hirofumi kn-aut-name=ИвХФНGОj kn-aut-sei=ИвХФ kn-aut-mei=НGОj aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Civil Engineering END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1-2 article-no= start-page=9 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ultra-Micro Hardness Testing and Microscopic Deformationof Polycrystalline Aluminum en-subtitle= kn-subtitle= en-abstract= kn-abstract=The evaluation of microscopic inhomogeneity of polycrystalline aluminum is performed by measuring the hardness in respective grains. The recently developed ultra-micro hardness tester is used and the effects of the test pattern, the indentation load and the indenting velocity are examined. Then, the relationship between the increase in the hardness caused by the work hardening and the deformation of respective grains are statistically investigated. The hardness testing mode in which the initial load is applied before the onset of measurement gives more stable results than the testing mode without the initial load. The test condition with the indentation load of 9.8mN and the indentation velocity of 0.2 Г╩m/sec seems to be optimum and gives the least dispersion of the measured values in grains. It is shown that the hardness values of respective grains in polycrystalline aluminum as well as their dispersion increase with the applied plastic strain. Discussion is made on the microscopic deformation behavior of polycrystalline aluminum. en-copyright= kn-copyright= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name=ИвХФХРОб kn-aut-sei=ИвХФ kn-aut-mei=ХРОб aut-affil-num=1 ORCID= en-aut-name=TsuboiTomoaki en-aut-sei=Tsuboi en-aut-mei=Tomoaki kn-aut-name=Т╪ИфТqП║ kn-aut-sei=Т╪Иф kn-aut-mei=ТqП║ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Engineering and Cooperative Research Center,Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Engineering END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microscopic Observation of Plastic Deformation of Polycrystalline Aluminum by Laser Scanning Microscope en-subtitle= kn-subtitle= en-abstract= kn-abstract=Free surface of polycrystalline metal becomes roughened after plastic deformation. The surface roughening is closely related to the inhomogeneity of polycrystalline metals, that is, to the inhomogeneous plastic deformation of respective grains. In the present study, inhomogeneous deformation on the free surface of polycrystalline aluminum specimen during uniaxial tension is studied. The inhomogeneous deformation of grains in the central area of the free surface of specimen is observed by the laser scanning microscope, while the inhomogeneous deformation perpendicular to the surface is studied by the laser scanning microscope as well as the stylus measuring instrument. It is shown that the surface roughness and the strain of respective grains increase with the applied strain. Discussions are made on the change in the surface roughness, the strain in each grain and the slip-line angles with the applied strain. en-copyright= kn-copyright= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name=ИвХФХРОб kn-aut-sei=ИвХФ kn-aut-mei=ХРОб aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=HualinSong kn-aut-sei=Hualin kn-aut-mei=Song aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=AkagiYasuo kn-aut-sei=Akagi kn-aut-mei=Yasuo aut-affil-num=3 ORCID= en-aut-name=ShimizuIchiro en-aut-sei=Shimizu en-aut-mei=Ichiro kn-aut-name=Р┤РЕИъШY kn-aut-sei=Р┤РЕ kn-aut-mei=ИъШY aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Engineering and Cooperative Research Center,Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Engineering, Okayama University affil-num=3 en-affil= kn-affil=NEC Hiroshima, Ltd., Higashi?Hiroshima affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Engineering, Okayama University END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=2 article-no= start-page=91 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1997ФNЙкОRМзЙ║В╔ФнР╢В╡В╜ПWТcРHТЖУ┼К│О╥ВйВчХкЧгВ│ВъВ╜Т░К╟ПoММРлСхТ░Л█EHEC O157 : H7В╠ГpГЛГXГtГBБ[ГЛГhГQГЛУdЛCЙjУоЦ@В╔ВцВщИтУ`ОqЙЁР═ kn-title=Molecular typing of enterohemorrhagic Escherichia coli O157 : H7 isolates derived from an outbreak in Okayama, Japan in 1997 by pulsed-field gel electrophoresis en-subtitle= kn-subtitle= en-abstract=1997ФN6МОВ╔ЙкОRМзЙ║В╠R-ХaЙ@В┼Т░К╟ПoММРлСхТ░Л█EHEC O157 : H7В╔ВцВщПWТcРHТЖУ┼ВкФнР╢В╡В╜бВ╗В╠К│О╥ВиВцВ╤РHН▐В┼ВаВщУ·Ц{В╗В╬ВйВчХкЧгВ│ВъВ╜EHEC O157 : H7В╠Л█КФВЁГpГЛГXГtГBБ[ГЛГhГQГЛУdЛCЙjУоЦ@(PFGE)ВЁОgЧpВ╡В─ИтУ`ОqЙЁР═ВЁНsВ┴В╜б13Ц╝В╠К│О╥ВйВчХкЧгВ│ВъВ╜Л█КФВ╠ИтУ`ОqМ^В═У·Ц{ В╗В╬ВйВчХкЧгВ│ВъВ╜Л█КФВ╞ИъТvВ╡В╜бП]В┴В─У·Ц{В╗В╬ВйВчХкОUВ│ВъВ╜EHEC O157 : H7ВкПWТcРHТЖУ┼В╠М┤ИЎВ┼ВаВщВ▒В╞ВкЙЁВ┴В╜бВ│ВчВ╔В▒ВъВчВ╠Л█КФВ╠ИтУ`ОqМ^В═1996ФNВ╔НLУЗМзВиВцВ╤ХЯЙкМзВ╠Р╝У·Ц{В╔ПWТcРHТЖУ┼ВкФнР╢В╡В╜Л█КФВ╠Г^ГCГvIaМ^В╞Ч▐ОЧВ╡В─ВвВ╜бВ▒В╠В▒В╞В═В▒В╠ИтУ`ОqГ^ГCГvВ╠Ч▐ОЧВ╡В╜Л█КФВ╠К┤РїВкР╝У·Ц{В┼ЛОФNВйВчНLВкВ┴В─ВвВщВ▒В╞ВЁОжВ╡В─ВвВщб kn-abstract=Thirteen enterohemorrhagic Escherichia coli O157 : H7 (EHEC) isolates derived from the patients of an outbreak in the R-hospital in Okayama Japan and one isolated from the ingredients of Japanese noodles in June 1997 were analyzed by molecular typing using pulsed-field gel electrophoresis (PFGE). The PFGE patterns of the patients were almost the same as the patterns of the Japanese noodle ingredients. Therefore, the EHEC O157 : H7 derived from the food was considered to have caused the outbreak in the R-hospital. The molecular typing of isolates from the patients and the Japanese noodle ingredients was almost the same as that of isolates from outbreaks in Hiroshima and Fukuoka prefectures classified as type Ia in 1996 by PFGE analysis. These results indicate that EHEC O157 : H7 strains with a similar PFGE type Ia pattern have already spread throughout western Japan since last year. en-copyright= kn-copyright= en-aut-name=MiyamotoKanji en-aut-sei=Miyamoto en-aut-mei=Kanji kn-aut-name=Л{Ц{К░Об kn-aut-sei=Л{Ц{ kn-aut-mei=К░Об aut-affil-num=1 ORCID= en-aut-name=SakamotoKazunari en-aut-sei=Sakamoto en-aut-mei=Kazunari kn-aut-name=НтЦ{ИъРм kn-aut-sei=НтЦ{ kn-aut-mei=ИъРм aut-affil-num=2 ORCID= en-aut-name=NiiyaMasami en-aut-sei=Niiya en-aut-mei=Masami kn-aut-name=РVТJПЯФ№ kn-aut-sei=РVТJ kn-aut-mei=ПЯФ№ aut-affil-num=3 ORCID= en-aut-name=ChenJing en-aut-sei=Chen en-aut-mei=Jing kn-aut-name=Т┬Р├ kn-aut-sei=Т┬ kn-aut-mei=Р├ aut-affil-num=4 ORCID= en-aut-name=AbeEriko en-aut-sei=Abe en-aut-mei=Eriko kn-aut-name=ИвХФКGЧЭОq kn-aut-sei=ИвХФ kn-aut-mei=КGЧЭОq aut-affil-num=5 ORCID= en-aut-name=OkazakiYuka en-aut-sei=Okazaki en-aut-mei=Yuka kn-aut-name=ЙкНшЦ∙Й┴ kn-aut-sei=ЙкНш kn-aut-mei=Ц∙Й┴ aut-affil-num=6 ORCID= en-aut-name=ShiraiKiyoko en-aut-sei=Shirai en-aut-mei=Kiyoko kn-aut-name=ФТИфКьСуОq kn-aut-sei=ФТИф kn-aut-mei=КьСуОq aut-affil-num=7 ORCID= en-aut-name=GodaNoriko en-aut-sei=Goda en-aut-mei=Noriko kn-aut-name=НЗУcУTОq kn-aut-sei=НЗУc kn-aut-mei=УTОq aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФСц2УрЙ╚ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=6 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=7 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ affil-num=8 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ en-keyword=EHEC O157: H7 (Т░К╟ПoММРлСхТ░Л█EHEC O157 : H7) kn-keyword=EHEC O157: H7 (Т░К╟ПoММРлСхТ░Л█EHEC O157 : H7) en-keyword=PFGE (ГpГЛГXГtГBБ[ГЛГhГQГЛУdЛCЙjУоЦ@) kn-keyword=PFGE (ГpГЛГXГtГBБ[ГЛГhГQГЛУdЛCЙjУоЦ@) en-keyword=outbreak (ПWТcК┤Рї) kn-keyword=outbreak (ПWТcК┤Рї) en-keyword=molecular typing (ИтУ`ОqЙЁР═) kn-keyword=molecular typing (ИтУ`ОqЙЁР═) END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=1 article-no= start-page=25 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A surgical case of small intestinal anisakiasis with symptoms of ileus kn-title=ГCГМГEГXП╟ПєВ┼ФнП╟В╡В╜ПмТ░ГAГjГTГLГXП╟В╠ВPЧс en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a surgical case of intestinal anisakiasis in which we identified a complete larva. A 48-year-old man complaining of epigastralgia after eating roasted mackerel was admitted to the hospital with a diagnosis of ileus with peritonitis. Abdominal CT showed dilatation and partial thickening of the small intestine. An emergency operation was carried out. On laparotomy, severe stricture of the jejunum was revealed. The affected intestine was resected. A larva whose head was invading the mucosa was found in the resected portion of the jejunum, and we diagnosed the case as intestinal anisakiasis. en-copyright= kn-copyright= en-aut-name=FujiiSayaka en-aut-sei=Fujii en-aut-mei=Sayaka kn-aut-name=УбИфР┤НБ kn-aut-sei=УбИф kn-aut-mei=Р┤НБ aut-affil-num=1 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=Р╝Н]Кw kn-aut-sei=Р╝Н] kn-aut-mei=Кw aut-affil-num=2 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=р_ЦьЧ║Ху kn-aut-sei=р_Ць kn-aut-mei=Ч║Ху aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=У┐ЙiПоФV kn-aut-sei=У┐Йi kn-aut-mei=ПоФV aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYousuke en-aut-sei=Tsunemitsu en-aut-mei=Yousuke kn-aut-name=ПэМїЧmХу kn-aut-sei=ПэМї kn-aut-mei=ЧmХу aut-affil-num=5 ORCID= en-aut-name=OotsukaShinya en-aut-sei=Ootsuka en-aut-mei=Shinya kn-aut-name=СхТ╦с┴Н╞ kn-aut-sei=СхТ╦ kn-aut-mei=с┴Н╞ aut-affil-num=6 ORCID= en-aut-name=MiyoshiKazuya en-aut-sei=Miyoshi en-aut-mei=Kazuya kn-aut-name=ОOНDШaЦч kn-aut-sei=ОOНD kn-aut-mei=ШaЦч aut-affil-num=7 ORCID= en-aut-name=TakahashiMasahiko en-aut-sei=Takahashi en-aut-mei=Masahiko kn-aut-name=НВЛ┤Р│ХF kn-aut-sei=НВЛ┤ kn-aut-mei=Р│ХF aut-affil-num=8 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ИюК_ЧD kn-aut-sei=ИюК_ kn-aut-mei=ЧD aut-affil-num=9 ORCID= en-aut-name=OosakiToshihide en-aut-sei=Oosaki en-aut-mei=Toshihide kn-aut-name=СхНшПrЙp kn-aut-sei=СхНш kn-aut-mei=ПrЙp aut-affil-num=10 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=КтК_ФОЦд kn-aut-sei=КтК_ kn-aut-mei=ФОЦд aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=2 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=3 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=4 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=5 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=6 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=7 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=8 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=9 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=10 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ affil-num=11 en-affil= kn-affil=НСЧзХaЙ@Л@Н\ХЯОRИуЧ├ГZГУГ^Б[Б@КOЙ╚ en-keyword=ПмТ░ГAГjГTГLГXП╟ Бismall intestinal anisakiasisБj kn-keyword=ПмТ░ГAГjГTГLГXП╟ Бismall intestinal anisakiasisБj en-keyword=ГCГМГEГX БiileusБj kn-keyword=ГCГМГEГX БiileusБj END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue= article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Toward Understanding of Regional Climate in East Asia around the Last Glacial Maximum with Attention to the Seasonal Cycle and Daily Meteorological Systems kn-title=УМГAГWГAВ╠ЛGР▀ГTГCГNГЛВтУ·БXВ╠ЛCП█В╔ТНЦ┌В╡В╜Н┼ПIХXК·НаВ╠ЛCМєК┬ЛлВ╠ЧЭЙЁВ╓М№ВпВ─ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Regional climate system in East Asia shows the characteristic seasonal cycle affected by the Asian monsoon with various types of its sub-systems. The seasonal cycle there is also related greatly to behaviors of the frontal zones which are the boundaries of these sub-systems. Since the variation of global-scale environment such as the global warming influences on each monsoon sub-system in rather different manner, it is necessary to understand the joint effects of these subsystems, in order to predict the regional climate change in East Asia in the global warming. In such research, it would be also useful to examine the features in the ice age, as an opposite extreme situation against the global warming. Thus the present paper will discuss some viewpoints in investigating the regional climate in the Last Glacial Maximum with attention to the seasonal cycle and daily meteorological systems. en-copyright= kn-copyright= en-aut-name=KatoKuranoshin en-aut-sei=Kato en-aut-mei=Kuranoshin kn-aut-name=Й┴УбУрхUРi kn-aut-sei=Й┴Уб kn-aut-mei=УрхUРi aut-affil-num=1 ORCID= en-aut-name=IkedaShoichiro en-aut-sei=Ikeda en-aut-mei=Shoichiro kn-aut-name=ТrУcП╦ИъШY kn-aut-sei=ТrУc kn-aut-mei=П╦ИъШY aut-affil-num=2 ORCID= en-aut-name=AbeKana en-aut-sei=Abe en-aut-mei=Kana kn-aut-name=ИвХФЙ┴У▐ kn-aut-sei=ИвХФ kn-aut-mei=Й┴У▐ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwЛ│ИчКwХФЧЭЙ╚Л│О║ affil-num=2 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ОйСRЙ╚КwМдЛЖЙ╚РцТ[КюСbЙ╚КwРъНU affil-num=3 en-affil= kn-affil=ЙкОRСхКwЛ│ИчКwХФЧЭЙ╚Л│О║ en-keyword=Climate in East Asia kn-keyword=Climate in East Asia en-keyword=Seasonal cycle kn-keyword=Seasonal cycle en-keyword=Frontal zone kn-keyword=Frontal zone en-keyword=Last Glacial Maximum kn-keyword=Last Glacial Maximum END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=5-6 article-no= start-page=505 end-page=515 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Zinc metabolism in the endotoxin-treated rats kn-title=ГGГУГhГgГLГVГУВкС╠УрИЯЙФСуО╙В╔ЛyВ┌В╖ЙeЛ┐В╔К╓В╖ВщО└М▒УIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of endotoxin administration on zinc metabolism was studied in rats. In the endotoxin-treated rats, serum zinc concentration was significantly reduced as compared to saline-treated rats (control group). On the other hand, hepatic zinc concentration was significantly increased after endotoxin administration as compared to the control group. However, the zinc concentrations of the liver cell components showed slightly dissimilarity. In the mitochondria and cytsol, the concentration increased significantly after endotoxin administration as compared to the control group, whereas no change was observed in the microsomes. Furthermore, we have examined whether the increase of the zinc level in the cytosol of the liver is associated with zinc-binding protein metallothioneins (MTs) or not. MTs also increased significantly after endotoxin administration. Furthermore hepatic MTs were analyzed for MT isoforms. In the endotoxin-treated MT-II was the major Iso-MT. Judging from these results and some other published reports, the role of zinc metabolism in endotoxemia is proposed to be as follows. In endotoxemia the serum zinc concentration is reduced and as a result the production of superoxide by polymorphonuclear leukocytes is increased as zinc has an inhibitory effect on it. This free radical helps the host against the organism. On the other hand zinc accumulation in the liver following endotoxin administration increases the activity of the zinc binding-enzyme and also stabilizes the plasma membrane. MTs induced by endotoxin protect the host from the harmful effects of the free radical in the host by its scavenging action. en-copyright= kn-copyright= en-aut-name=MatsumiMasaki en-aut-sei=Matsumi en-aut-mei=Masaki kn-aut-name=П╝ОOП╣Оў kn-aut-sei=П╝ОO kn-aut-mei=П╣Оў aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЦГРМБEСhР╢КwЛ│О║ en-keyword=ГGГУГhГgГLГVГУ kn-keyword=ГGГУГhГgГLГVГУ en-keyword=ИЯЙФ kn-keyword=ИЯЙФ en-keyword=ГБГ^ГНГ`ГIГlГCГУ kn-keyword=ГБГ^ГНГ`ГIГlГCГУ END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=5-6 article-no= start-page=463 end-page=472 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on clinical course and prognosis of chronic pancreatitis Part 1. Chief complaint, pancreatogram, exocrine function and glucose tolerance at diagnosis, and their serial changes kn-title=ЦЭРлфXЙКВ╠МoЙ▀В╞Ч\МуВ╔К╓В╖ВщМдЛЖ Сц1Х╥ РfТfОЮВ╠ПєС╘В╞фXК╟СЬБCфXКOХкФхЛ@Ф\БCС╧УЬФ\В╠МoОЮУIХ╧Й╗В╔В┬ВвВ─ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the chief complaints, pancreatograms, pancreatic exocrine function and glucose tolerance at diagnosis and their serial changes in chronic pancreatitis (CP), 112 patients with alcoholic CP, nine with biliary CP and 49 with idiopathic CP were studied. The following conclusions were obrained. Seventy-seven patients with alcoholic CP, nine with biliary CP and 22 with idiopahtic CP had presented with recurrent abdominal pain for more than one year before the time of diagnosis. Chief complaints consisted of abdominal pain , diabetes mellitus and others. Proportion of patients with abdominal pain was significantly higher in alcoholic CP than in idiopathic CP. Elderly patients with CP presented with abdominal pain less frequently than non-elderly patients. These findings indicate that chronic pancreatitis should be considered when diagnosing and treating diabetics and the elderly. Patients with alcoholic CP were significantly younger than those with nonalcoholic CP at diagnosis. Sex distribution showed male predominance in alcoholic CP and female predominance in nonalcoholic CP. Calcification in the pancreas was detected more frequently in alcoholic CP than in nonalcoholic CP. The number of patients with CP increased in more recent years. Alcoholic CP showed more severe damage of the pancreas than nonalcoholic CP at the time of diagnosis. No differences between alcoholic CP and nonalcoholic CP were found in the frequency of the progressive changes in pancreatograms. Deteriorative changes in pancreatic exocrine function were not related with etiological category, but improvement was observed frequently in nonalcoholic CP. The deterioration of glucose tolerance was not related with etiological category, drinking habit and pain relief. en-copyright= kn-copyright= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=ОOСюМ[Х╢ kn-aut-sei=ОOСю kn-aut-mei=М[Х╢ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=ЦЭРлфXЙК kn-keyword=ЦЭРлфXЙК en-keyword=фXК╟СЬ kn-keyword=фXК╟СЬ en-keyword=фXКOХкФхЛ@Ф\ kn-keyword=фXКOХкФхЛ@Ф\ en-keyword=С╧УЬФ\ kn-keyword=С╧УЬФ\ en-keyword=МoОЮУIХ╧Й╗ kn-keyword=МoОЮУIХ╧Й╗ END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=63 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of extravascular lung water after hepatic ischemia by Pringle's maneuver Part 1. In regard to the increase of the extravascular lunh water and its cause kn-title=Pringle Ц@Л}РлК╠ЧмУ№ММНsО╒ТfВ╠ФxММК╟КOРЕХкЧ╩В╔ВиВцВ┌В╖ЙeЛ┐Б@Сц1Х╥Б@ФxММК╟КOРЕХкЧ╩В╠СЭЙ┴В╞В╗В╠РмИЎВЁТЖРSВ╞В╡В─ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the effect of total hepatic ischemia on pulmonary organs, extravascular lung water (EVLW) was experimentally measured using a modified double indicator dilution method before and after interruption of the hepatic blood flow using Pringle's maneuver. The follow-ing results were obtained : 1) EVLW was significantlly increased more than one hour after temporary total hepatic ischemia. 2) Temporary hypotension resulted in little increase of EVLW by removing and replacing some blood volume through the femoral artery. 3) Pumonary interstitial edema was histologically and maroscopically observed in the Pringle's maneuver group. 4) Marked metabolic acidosis and elevation of serum transaminase were revealed after temporary hepatic ischemia. These findings auggest that pulmonary interstitial edema may result from sfter temporary total hepatic ischemia by Pringle's maneuver and the changes of EVLW are caused by increased permeability due to liver injury, metabolic acidosis and portal congestion. en-copyright= kn-copyright= en-aut-name=YokoyamaNobuji en-aut-sei=Yokoyama en-aut-mei=Nobuji kn-aut-name=ЙбОRРLУё kn-aut-sei=ЙбОR kn-aut-mei=РLУё aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=Pringle Ц@Л}РлК╠ЧмУ№ММНsО╒Тf kn-keyword=Pringle Ц@Л}РлК╠ЧмУ№ММНsО╒Тf en-keyword=ФxММК╟КOРЕХкЧ╩ kn-keyword=ФxММК╟КOРЕХкЧ╩ END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=37 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation for malignancy using DNA analysis and the effect of medroxyprogesterone acetate on cell kinetics in primary breast cancer kn-title=Кj DNA Ч╩В╔ВцВщУ√КрВ╠ИлРлУxФ╗ТшВ╚ВчВ╤В╔УрХкФхЧ├Ц@В╠НьЧpЛ@ПШВ╠МдЛЖБ\Flow cytometry В╔ВцВщЙЁР═Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate for primary breast cancer, flow cytometric DNA analysis has been performed on 105 paraffin-embedded tissues. The S-phase fraction and proliferation index correlated significantly with clincopathological factors, sunh as n-number, tumor size, histological stage and hormone receptors. However, there was no correlation between the level of ploidy and the clinicopathological factors. DNA analysis using flow cytometry was found to be useful for the estimation of prognosis and evaluation of malignancy of breast cancer. The effect of medroxyprogesterone acetate (MPA) on primary breast cancer cell kinetics was investigated by flow cytometry. Nuclear DNA contents were measured in 67 cases. MPA, 1,200mg/day, was orally administered for two weeks in 12 cases (MPA group) and the remain-ing cases (n-MPA group) served as the controls, until the day before operatopn. The DNA histograms were compared between both groups. The mean percentage of G0 + G1 phase was higher and that of S-phase and G2 + M phase, lower, in the MPA group than in the n-MPA group. Especially in estorogen receptor-positive and premenopausal cases, significant differ-ences were present between both groups. These results suggest that MPA could inhibit DNA synthesis with a delay of the cell cycle progression in human breast cancer. en-copyright= kn-copyright= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name=УyИфМ┤ФОЛ` kn-aut-sei=УyИфМ┤ kn-aut-mei=ФОЛ` aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=flow cytometry kn-keyword=flow cytometry en-keyword=У√Кр kn-keyword=У√Кр en-keyword=Кj DNA Ч╩ kn-keyword=Кj DNA Ч╩ en-keyword=ИлРлУx kn-keyword=ИлРлУx en-keyword=medroxyprogesterone acetate (MPA) kn-keyword=medroxyprogesterone acetate (MPA) END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=183 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models kn-title=Ф]ММК╟Э╣ПkВ╠ФнР╢Л@ПШВ╞ОбЧ├В╔К╓В╖ВщО└М▒УIМдЛЖ Сц2Х╥ О└М▒УIТxФнРлФ]ММК╟Э╣ПkВ╔С╬В╖Вщ PGI2 analogue, Thromboxane A2 НЗРмНyСfСjКQН▄, Ca ЭhНRН▄В╠М°Й╩ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8Г╩g/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage. en-copyright= kn-copyright= en-aut-name=MotokiMototsugu en-aut-sei=Motoki en-aut-mei=Mototsugu kn-aut-name=М│Ц╪КюОk kn-aut-sei=М│Ц╪ kn-aut-mei=КюОk aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФФ]Р_МoКOЙ╚Л│О║ en-keyword=cerebral vasospasm kn-keyword=cerebral vasospasm en-keyword=thromboxane A2 kn-keyword=thromboxane A2 en-keyword=OP-41483 kn-keyword=OP-41483 en-keyword=OKY-046 kn-keyword=OKY-046 en-keyword=nifedipine kn-keyword=nifedipine END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=1 article-no= start-page=31 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Animal Experiment on Functional Features of Eggs Stated to be Hypoallergenic for People with Food Allergies kn-title=ТсГAГМГЛГMБ[ФнП╟РлВкМ╛ЛyВ│ВъВ─ВвВщМ{ЧСВ╠Л@Ф\У┴РлВ╔К╓В╖ВщУоХиО└М▒ en-subtitle= kn-subtitle= en-abstract=РHХиГAГМГЛГMБ[ВЁОЭВ┬П┴ФяО╥В╠МoМ▒В╔КюВ├ВвВ─ТсГAГМГЛГMБ[ЧUФнРлВ┼ВаВщВ▒В╞ВкМ╛ЛyВ│ВъВ─ВвВщМ{ЧСВ╔В┬ВвВ─БCТсГAГМГЛГMБ[ЧUФнРлВ╠ЧLЦ│В╞Й╚КwУIВ╚НкЛТВЁЦ╛ВчВйВ╔В╖ВщВ╜В▀В╔УоХиВЁЧpВвВ╜О└М▒ВЁВиВ▒В╚В┴В╜БDО└М▒В╔В═ГAГМГЛГMБ[ВЁФнП╟В╖ВщВ▒В╞ВкТmВчВъВ─ВвВщГЙГbГgВ╠МnУЭВ┼ВаВщBrown Norway ratБiBNГЙГbГgБjВЁЧpВвБCВ▒В╠М{ЧСВЁНмВ║НЮВёВ╛ОФЧ┐В┼ОФИчВ╡В╜БDС╬П╞В╞В╡В─БCОsФ╠В╠М{ЧСБiХБТ╩ЧСБjВ┼УпЧlВ╔ОФИчВ╡В╜БDООМ▒ЧСВ┼ОФИчВ╡В╜BNГЙГbГgВ┼В═БCЛєТ░В╞ЙёТ░СgРDВ╠IgEЧzРлН╫ЦEВ╠ЦзУxВ═ХБТ╩ЧСВ┼ОФИчВ╡В╜ПъНЗВ╔ФфКrВ╡В─СхВлВнТсЙ║В╡В╜БDСgРDТЖВ╠IgEЧzРлН╫ЦEВ╠СхХФХкВ═ФьЦЮН╫ЦEВ┼ВаВщВ▒В╞ВкТmВчВъВ─ВвВщВ▒В╞ВйВчООМ▒ЧСМQВ╔ВиВпВщПмТ░СgРDВ╠ФьЦЮН╫ЦEЦзУxВ═ТсЙ║В╡В╜БDВ│ВчВ╔БCММТЖВ╠НDО_ЛЕРФВ═УпЧlВ╔ООМ▒ЧСВ╔ВцВщОФИчВ┼ТсЙ║В╡В╜БDИъХ√БCММР┤В╠IgEФZУxВ╔В═Р█ОцВ│В╣В╜ЧСВ╔ВцВщИсВвВ═ФFВ▀ВчВъВ╚ВйВ┴В╜БDИ╚ПуВ╠МЛЙ╩В═БCООМ▒ЧСВЁР█ОцВ╡В╜ПъНЗБCТ╩ПэВ╠ЧСВ╠Р█ОцВ╔ФфКrВ╡В─СжОЮМ^ГAГМГЛГMБ[П╟ПєВ╠ФнР╢В╔Т╝Р┌УIВ╔К╓Ч^В╖ВщФьЦЮН╫ЦEВ╞НDО_ЛЕВ╠ЧUУ▒ВтСЭРBВкСгРiВ│ВъВ╔ВнВвВ╞НlВжВчВъБCВ▒В╠В▒В╞ВкБCООМ▒ЧСВкГAГМГЛГMБ[ВЁИ°ВлЛNВ▒В╡В╔ВнВвИъИЎВ┼ВаВщВ╞РДО@В│ВъВщБD kn-abstract=Functional features concerned with low proallergic natures were examined using an allergy-inducible rat strain (Brown Norway rat; BN rat) on hen's eggs which have been empirically mentioned as hypoallergenic for patients suffering from food allergies (experimental eggs). BN rats were fed on feed containing whole experimental eggs (feed E) and whole normal eggs (control feed, feed C). The densities of immunoglobulin E (IgE)-positive cells, have reported to be IgE-bearing mast cells, in the jejunum and ileum of BN rats fed on experimental-egg-containing feed were lower than those of BN rats fed on normal-egg-containing feed. The number of blood eosinophils was also lower in BN rats fed on feed E. Serum IgE levels were no different between BN rats fed on feed E and feed C. These results indicate that the low proallergic nature of hen's eggs studied in the present study is due to the dereased ability of experimental eggs to facilitate the proliferation and induction of mast cells in the intestinal tissue. en-copyright= kn-copyright= en-aut-name=NagatoKumiko en-aut-sei=Nagato en-aut-mei=Kumiko kn-aut-name=Т╖ЦхЛvФ№Оq kn-aut-sei=Т╖Цх kn-aut-mei=ЛvФ№Оq aut-affil-num=1 ORCID= en-aut-name=AbeAsaki en-aut-sei=Abe en-aut-mei=Asaki kn-aut-name=ИвХФРєОў kn-aut-sei=ИвХФ kn-aut-mei=РєОў aut-affil-num=2 ORCID= en-aut-name=NarabaraKiyoaki en-aut-sei=Narabara en-aut-mei=Kiyoaki kn-aut-name=УшМ┤Р┤М░ kn-aut-sei=УшМ┤ kn-aut-mei=Р┤М░ aut-affil-num=3 ORCID= en-aut-name=KondoYasuhiro en-aut-sei=Kondo en-aut-mei=Yasuhiro kn-aut-name=Л▀УбНNФО kn-aut-sei=Л▀Уб kn-aut-mei=НNФО aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ЙЮЧpУоХиЙ╚КwГRБ[ГX affil-num=2 en-affil= kn-affil=ЙЮЧpУоХиЙ╚КwГRБ[ГX affil-num=3 en-affil= kn-affil=ЙЮЧpУоХиЙ╚КwГRБ[ГX affil-num=4 en-affil= kn-affil=ЙЮЧpУоХиЙ╚КwГRБ[ГX en-keyword=egg kn-keyword=egg en-keyword=food allergy kn-keyword=food allergy en-keyword=IgE kn-keyword=IgE en-keyword=mast cells kn-keyword=mast cells END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=161 end-page=171 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The accumulation of metallothionein in the rat kidney injured by temporal ischemia kn-title=ЛХММРлРtПЭКQВ╔ВцВщИЯЙФСуО╙В╞РtУрГБГ^ГНГ`ГIГlГCГУВ╠Х╧УоВ╔К╓В╖ВщО└М▒УIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The renal and hepatic metallothionein (MT) and serum zinc levels were studied in rats following renal ischemia, to clarify the effects of renal damage on the zinc metabolism. The serum zinc concentration began to decrease on the 4th day in the bilateral renal ischemic rat. The accumulation of hepatic MT was stimulated by sham operation and was augmented furthermore by renal ischemic damage. The renal MT level increased gradually and reached the maximum on the 3rd day in the bilateral renal ischemic rat. The MT level in the injured kidney was higher than that in the intact kidney in the unilateral renal ischemic rat. These results suggested that the mechanism of MT synthesis in the kidney was different from that in the liver, and that some local factor might induce MT in the injured kidney. en-copyright= kn-copyright= en-aut-name=MizukawaShun-ichi en-aut-sei=Mizukawa en-aut-mei=Shun-ichi kn-aut-name=РЕРьПrИъ kn-aut-sei=РЕРь kn-aut-mei=ПrИъ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЦГРМБEСhР╢КwЛ│О║ en-keyword=ИЯЙФ kn-keyword=ИЯЙФ en-keyword=ЛХММРлЛ}РлРtХsСS kn-keyword=ЛХММРлЛ}РлРtХsСS en-keyword=ГБГ^ГНГ`ГIГlГCГУ kn-keyword=ГБГ^ГНГ`ГIГlГCГУ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=581 end-page=590 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Response of luteinizing hormone and follicle stimulating hormone to luteinizing hormone-releasing hormone in prepubertal and pubertal chidren, as measured by a highly sensitive immunradiometric assay kn-title=LHRH ХЙЙ╫ООМ▒В╔ВцВщПмОЩК·В╠ГSГiГhГgГНГsГУХкФхЧ\ФїФ\В╔К╓В╖ВщМЯУвБ[НВР╕Уx LH, FSH СкТшЦ@ (IRMA Ц@) В╔ВцВщХкФхУоС╘В╠ЙЁР═Б[ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the age-related changes in the pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), the consentrations of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured before and after LH-RH administra-tion using the highly sensitive immunoradiometric assay (IRMA) in 283 normal children (161 males and 77 females) between 4 and 14 years old and in 22 patients (18 males and 4 females) with pituitary dwarfism. Then, the area of response above the basal level [integrated response(Г░)] of LH and FSH during 60 minutes after LH-RH injection was calculated to evaluate the pituitary response to LH-RH. The integrated LH responses progressively increased in the boys from 8 years of age and in the girls from 6 years of age, and they continued to increase up to 14 years of age. The integrated FSH response showed a significant decrease in all grups in the girls, but did not show any change in the boys. In patients with pituitary dwarfism who were subsequently found to be gonadotropin deficient, the level of Г░ LH60 was low (below-2SD) It is concluded that integrated responses of gonadotropins, especially LH, to LH-RH are useful to evaluate the maturation of the hypothalamic-pituitary-gonadal axis, and that incre-ment of LH responsiveness to LH-RH already begins before the onset of puberty. The peak appearance time of gonadotropins after LH-RH is also important in the assessment of the maturation of the hypothalamic-pituitary-gonadal axis because FSH reached its peak carlier in the pubertal group than in the prepubertal group. en-copyright= kn-copyright= en-aut-name=HiguchiJoji en-aut-sei=Higuchi en-aut-mei=Joji kn-aut-name=ФєМ√ПўУё kn-aut-sei=ФєМ√ kn-aut-mei=ПўУё aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФПмОЩЙ╚КwЛ│О║ en-keyword=LHRH kn-keyword=LHRH en-keyword=LH kn-keyword=LH en-keyword=FSH kn-keyword=FSH en-keyword=Й║РВС╠РлПмРlП╟ kn-keyword=Й║РВС╠РлПмРlП╟ en-keyword=ГSГiГhГgГНГsГУХкФхХsСS kn-keyword=ГSГiГhГgГНГsГУХкФхХsСS END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=549 end-page=559 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cardiac function and nutrition in patients with mitral valve disease kn-title=СmЦXХ┘ЦМП╟К│О╥В╠РSЛ@Ф\В╞ЙhЧ{ПсКQВ╔К╓В╖ВщМЯУв en-subtitle= kn-subtitle= en-abstract= kn-abstract=To examine the influence of cardiac function on the nutriture, operated cases of mitral valve disease were evaluated for preoperative cardiac function by morbid type and were examined for the influence of cardiac function on the pre- and post-operative nutriture. The findings revealed that the hypofunctional group showed no difference in visceral protein index from the normal group preoperatively, and showed significant decreases in % IBW, % TSF, and CHI, indexes of fat stores and skeletal muscle mass. The hypofunctional group also showed low value of PPD intracutaneous reaction, an index of the immunological status. The early postoperative nutriture of the hypofunctional group showed changes similar to those in the normal group and was less influenced by the preoperative cardiac function. These findings suggest that the cardiac function influences the body composition and immunological status and that somatometry and PPD intracutaneous reaction are useful for the nutritional assessment of heart diseases. en-copyright= kn-copyright= en-aut-name=MiyazakiItsuhiro en-aut-sei=Miyazaki en-aut-mei=Itsuhiro kn-aut-name=Л{НшИуТ├ФО kn-aut-sei=Л{Нш kn-aut-mei=ИуТ├ФО aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=СmЦXХ┘ЦМП╟ kn-keyword=СmЦXХ┘ЦМП╟ en-keyword=РSСЯИлЙtО┐ kn-keyword=РSСЯИлЙtО┐ en-keyword=РSЛ@Ф\ kn-keyword=РSЛ@Ф\ en-keyword=ЙhЧ{ПсКQ kn-keyword=ЙhЧ{ПсКQ en-keyword=ЙhЧ{Х]Й┐ kn-keyword=ЙhЧ{Х]Й┐ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=539 end-page=548 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study for safety of continuous wave ultrasound : Fetal death, anomalies, juvenile behavior, learning and fertility kn-title=Т┤Й╣ФgШAС▒ФgП╞О╦В╠И└СSРлВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rat fetuses were extra-abdominaly exposed to 2 MHz continuous wave ultrasound, with 1.5 or 2.5W/cЗu of spatial average (SATA) intensity, for 15 min at 7.5 to 11.5 days of pregnancy. Fetal anomalies were observed only in the groups exposed to 2.5 and 1.5W/cЗu at 9.5 days of pregnancy but its occurrence was not statistically significant. Intrauterine fetal deaths were most prevalent in the group exposed to 2.5W/cЗu at 9.5 days of pregnancy, followed by the group exposed to 2.5W/cm2 at 10.5 and 7.5 days of pregnancy. At three months after birth, the behavior (open field test), the learning ability (avoiding study and single straight pathway test) and the fertility of these exposed rats were compared with those in non-exposed rats. In the avoiding study, there was statistically less avoidability in the group exposed to 2.5W/cЗu at 9.5 days of pregnancy than the non-exposed group. In the other tests, no significant differences could be found between the exposed group and non-exposed group. These findings indicated that rat fetuses at 9.5 days of pregnancy are most senstive to continuous wave ultrasound exposure followed by fetuses at 10.5 or 7.5 days of pregnancy. en-copyright= kn-copyright= en-aut-name=KawaiJunichirou en-aut-sei=Kawai en-aut-mei=Junichirou kn-aut-name=Й═СКП~ИъШY kn-aut-sei=Й═СК kn-aut-mei=П~ИъШY aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФОYЙ╚ХwРlЙ╚КwЛ│О║ en-keyword=Т┤Й╣ФgШAС▒ФgП╞О╦ kn-keyword=Т┤Й╣ФgШAС▒ФgП╞О╦ en-keyword=Р╢ХиКwУIМ°Й╩ kn-keyword=Р╢ХиКwУIМ°Й╩ en-keyword=С┘ОeКяМ` kn-keyword=С┘ОeКяМ` en-keyword=КwПKООМ▒ kn-keyword=КwПKООМ▒ END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=95 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effects of acute respiratory pH changes on the activated coagulation time kn-title=ХККИЛ├М┼ОЮК╘В╔ВиВцВ┌В╖Л}РлМ─ЛzРл pH Х╧Й╗В╠ЙeЛ┐В╔К╓В╖ВщО└М▒УIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of acute respiratory acidosis and alkalosis on the activated coagulation time (ACT) of both pre-heparinized and post-heparinized blood samples were studied in adult mongrel dogs. The ACT of pre-heparinized samples, compared with the ACT at a normal pH, was significantly shortened with the progression of acidosis. The correlation coefficient between the ACT of pre-heparinized samples and the pH values during acidosis was 0.55 (p<0.01). During alkalosis, however, the ACT of pre-heparinized samples showed no significant changes. On the other hand, the ACT of post-heparinized samples, compared with the ACT at a normal pH, showed significant prolongation with the progression of both acidosis and aklalosis. The correlation coefficient between the ACT of post-heparinized samples and the pH values was -0.74 (p<0.001) during acidosis, and was 0.55 (p<0.01) during alkalosis. These results indicate that, although the mechanism of the alteration of ATC due to the acute respiratory pH changes seemed to be multifactorial, the ACT in the presence of pH abnormality does not reflect the actual blood concentration of heparin correctly. en-copyright= kn-copyright= en-aut-name=SetoKozo en-aut-sei=Seto en-aut-mei=Kozo kn-aut-name=РгМ╦НbСа kn-aut-sei=РгМ╦ kn-aut-mei=НbСа aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЦГРМБEСhР╢КwЛ│О║ en-keyword=В╓ГpГКГУ kn-keyword=В╓ГpГКГУ en-keyword=ХККИЛ├М┼ОЮК╘ kn-keyword=ХККИЛ├М┼ОЮК╘ en-keyword=М─ЛzРлГAГVГhБ[ГVГX kn-keyword=М─ЛzРлГAГVГhБ[ГVГX en-keyword=М─ЛzРлГAГЛГJГНБ[ГVГX kn-keyword=М─ЛzРлГAГЛГJГНБ[ГVГX END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=499 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion kn-title=ОqЛ{С╠КрВ╔С╬В╖ВщМoфTСЦН╕Т┤Й╣ФgТfСwЦ@В╞MRIВ╠ЧLЧpРлВ╔В┬ВвВ─Б\Л╪СwРZПБВ╞МzХФРZПБВ╠Х]Й┐Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (?1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma. en-copyright= kn-copyright= en-aut-name=YoshiharaEisuke en-aut-sei=Yoshihara en-aut-mei=Eisuke kn-aut-name=ЛgМ┤ЙpЙю kn-aut-sei=ЛgМ┤ kn-aut-mei=ЙpЙю aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФОYЙ╚ХwРlЙ╚КwЛ│О║ en-keyword=ОqЛ{С╠Кр kn-keyword=ОqЛ{С╠Кр en-keyword=МoфTСЦН╕Т┤Й╣ФgТfСwЦ@ kn-keyword=МoфTСЦН╕Т┤Й╣ФgТfСwЦ@ en-keyword=MRI kn-keyword=MRI en-keyword=Л╪СwРZПБ kn-keyword=Л╪СwРZПБ en-keyword=МzХФРZПБ kn-keyword=МzХФРZПБ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=483 end-page=487 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of fibromuscular dysplasia with large cerebral aneurysm at the bifurcation of the vertebral artery to cerebellar artery associated with renal hypertensin kn-title=РtУоЦмРлНВММИ│В╔РДНЬУоЦмБ\МуЙ║ПмФ]УоЦмХкКЄХФЛРСхУоЦмсОВЁНЗХ╣В╡В╜Р№И█Л╪РлИ┘М`РмВ╠ИъЧс en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 27-year-old man was admitted with symptoms of hypertension and headache. His soft palate and uvula were deviated to the right. The left side of his tongue was atrophic with fasciculation. Plasma renin activity, plasma angiotensin-I and aldosteron levels were elevated. Renal arteriography revealed membranous-stenosis with poststenotic dilation at the mid and peripheral portion of the renal artery, which was consistent with the findings of fibromus-cular dysplasia (FMD). Large aneurysm at the bifucation of the vertebral artery to postero-inferior cerebellar artery was observed by cerebral arteriography. The patient was treated with medication for renal hypertension. Percutaneous embolization of the aneurysm was performed. In conclusion, the present case had a giant cerebral aneurysm, located at a rare portion and was diagnosed before its rupture. Examination of the cerebral artery was essential in renal FMD. en-copyright= kn-copyright= en-aut-name=NakagawaHiroshi en-aut-sei=Nakagawa en-aut-mei=Hiroshi kn-aut-name=ТЖРьЧT kn-aut-sei=ТЖРь kn-aut-mei=ЧT aut-affil-num=1 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name=СРТnП╚Са kn-aut-sei=СРТn kn-aut-mei=П╚Са aut-affil-num=2 ORCID= en-aut-name=OkaTakefumi en-aut-sei=Oka en-aut-mei=Takefumi kn-aut-name=ЙкКxХ╢ kn-aut-sei=Йк kn-aut-mei=КxХ╢ aut-affil-num=3 ORCID= en-aut-name=UrabeNorio en-aut-sei=Urabe en-aut-mei=Norio kn-aut-name=РшХФСеР╢ kn-aut-sei=РшХФ kn-aut-mei=СеР╢ aut-affil-num=4 ORCID= en-aut-name=NogamiKunio en-aut-sei=Nogami en-aut-mei=Kunio kn-aut-name=ЦьПуЦMХv kn-aut-sei=ЦьПу kn-aut-mei=ЦMХv aut-affil-num=5 ORCID= en-aut-name=TakemotoMasao en-aut-sei=Takemoto en-aut-mei=Masao kn-aut-name=Т|Ц{ЙыЧY kn-aut-sei=Т|Ц{ kn-aut-mei=ЙыЧY aut-affil-num=6 ORCID= en-aut-name=MorishitaNaoya en-aut-sei=Morishita en-aut-mei=Naoya kn-aut-name=РXЙ║Т╝Цч kn-aut-sei=РXЙ║ kn-aut-mei=Т╝Цч aut-affil-num=7 ORCID= en-aut-name=InoueKimihito en-aut-sei=Inoue en-aut-mei=Kimihito kn-aut-name=ИфПуМЎРm kn-aut-sei=ИфПу kn-aut-mei=МЎРm aut-affil-num=8 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=Т╥НFХv kn-aut-sei=Т╥ kn-aut-mei=НFХv aut-affil-num=9 ORCID= en-aut-name=TomitaSusumu en-aut-sei=Tomita en-aut-mei=Susumu kn-aut-name=ХxУcЛЬ kn-aut-sei=ХxУc kn-aut-mei=ЛЬ aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=6 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=7 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=8 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=9 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ affil-num=10 en-affil= kn-affil=ЙкОRСхКwИуКwХФФ]Р_МoКOЙ╚КwЛ│О║ en-keyword=Р№И█Л╪РлИ┘М`Рм kn-keyword=Р№И█Л╪РлИ┘М`Рм en-keyword=Ф]УоЦмсО kn-keyword=Ф]УоЦмсО en-keyword=РtУоЦмРлНВММИ│ kn-keyword=РtУоЦмРлНВММИ│ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=457 end-page=469 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Metallothionein induction in the rat kidneys by endotoxin and zinc administration kn-title=ГGГУГhГgГLГVГУВиВцВ╤ИЯЙФУКЧ^ГЙГbГgВ╔ВиВпВщРtГБГ^ГНГ`ГIГlГCГУВ╠ЧUУ▒В╔К╓В╖ВщО└М▒УIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Metallothionein (MT) induction in the rat kidneys by endotoxin and zinc was investigated at the MT-protein level and the MT-mRNA level. The MT-mRNA level increased 3-6 hr after endotoxin administration, which suggested that MT was not transported from an other organ, but was de novo synthesized. Two MT-protein isoforms, MT-ЗT and MT-ЗU, were induced by administration of both endotoxin and zinc. The maximum levels of the proteins were seen 9 hr after administration of endotoxin and zinc. The span life of the renal MT induced by zinc was shorter than that of the liver MT induced by zinc. The MT-ЗU isoform was predominantly induced by both inducers, endotoxin and zinc, and the ratios of MT-ЗU to MT-ЗT were relatively constant. The finding that MT-ЗT and MT-ЗU were almost equally induced by zinc in the liver indicate that MT induction is controlled by an organ-specific system. en-copyright= kn-copyright= en-aut-name=KanaiYoshizumi en-aut-sei=Kanai en-aut-mei=Yoshizumi kn-aut-name=ЛрЛПЛ`ПГ kn-aut-sei=ЛрЛП kn-aut-mei=Л`ПГ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЦГРМБEСhР╢КwЛ│О║ en-keyword=ГGГУГhГgГLГVГУ kn-keyword=ГGГУГhГgГLГVГУ en-keyword=ИЯЙФ kn-keyword=ИЯЙФ en-keyword=РtГБГ^ГНГ`ГIГlГCГУ kn-keyword=РtГБГ^ГНГ`ГIГlГCГУ en-keyword=НВСмЙtС╠ГNГНГ}ГgГOГЙГtГBБ[ kn-keyword=НВСмЙtС╠ГNГНГ}ГgГOГЙГtГBБ[ END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=973 end-page=981 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of quercetin on thermotolerance in NIH 3T3 cells : From a view point of cell survival kn-title=NIH 3T3 Н╫ЦEВ╠Й╖ФMС╧РлВ╔С╬В╖ВщГPГЛГZГ`ГУВ╠НьЧpБ@Сц1Х╥Б@Н╫ЦEВ╠Р╢С╢ЧжВйВчВ▌В╜ГPГЛГZГ`ГУВ╠НьЧp en-subtitle= kn-subtitle= en-abstract= kn-abstract=The inhibition of thermotolerance development by quercetin was examined in NIH 3T3 cells. The cytotoxicity of quercetin increased with the increase in the concentration (10,100Г╩g/ml) and duration (12,48,72 hours) of treatment. The cell killing effect of heat was not enhanced by quercetin (10Г╩g/ml) itself. Quercetin (10Г╩g/ml) inhibited the proliferation of cells for about 72 hours. Quercetin (10Г╩g/ml) delayed the development of thermotolerance, but did not decrease the degree of maximum thermotolerance. Quercetin (10Г╩g/ml) exibited no effect on the decay of thermotolerance. en-copyright= kn-copyright= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name=НХУcП╣НG kn-aut-sei=НХУc kn-aut-mei=П╣НG aut-affil-num=1 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=Х╜Ц╪П╦Хv kn-aut-sei=Х╜Ц╪ kn-aut-mei=П╦Хv aut-affil-num=2 ORCID= en-aut-name=KawasakiShouji en-aut-sei=Kawasaki en-aut-mei=Shouji kn-aut-name=РьНшП╦Уё kn-aut-sei=РьНш kn-aut-mei=П╦Уё aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФХ·О╦Р№ИуКwЛ│О║ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуКwХФХ·О╦Р№ИуКwЛ│О║ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуЧ├ЛZПpТZК·СхКwХФ en-keyword=ГPГЛГZГ`ГУ kn-keyword=ГPГЛГZГ`ГУ en-keyword=Й╖ФMС╧Рл kn-keyword=Й╖ФMС╧Рл en-keyword=Й╖ФMЧ├Ц@ kn-keyword=Й╖ФMЧ├Ц@ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=259 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 2. Г└-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase kn-title=ГCГУГ^Б[ГtГFГНГУХ└В╤В╔ГCГУГ^Б[ГtГFГНГУЧUФнН▄В╔К╓В╖ВщКюСbУIБEЧ╒П░УIМдЛЖБ@Сц2Х╥Б@Л}РлФёГКГУГpРлФТММХaК░ЙЁК·В╔ВиВпВщ Г└-Carboxyethylgermanium sesquioxide (Ge-132) В╠Ч╒П░М°Й╩ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy Бkdaunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)Бland patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.Бk2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in BБlGe-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=ХЯЦ{МїНG kn-aut-sei=ХЯЦ{ kn-aut-mei=МїНG aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Biological response modifier kn-keyword=Biological response modifier en-keyword=Acute nonlymphocytic leukemia kn-keyword=Acute nonlymphocytic leukemia en-keyword=Immunotherapy kn-keyword=Immunotherapy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=247 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 1. Effects of interferon and its inducers on neutrophil chemiluminescence kn-title=ГCГУГ^Б[ГtГFГНГУХ└В╤В╔ГCГУГ^Б[ГtГFГНГУЧUФнН▄В╔К╓В╖ВщКюСbУIБEЧ╒П░УIМдЛЖБ@Сц1Х╥Б@ГCГУГ^Б[ГtГFГНГУХ└В╤В╔ГCГУГ^Б[ГtГFГНГУЧUФнН▄В╠НDТЖЛЕ Chemiluminescence В╔ЛyВ┌В╖ЙeЛ┐ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate one the effects of interferon (IFN) and its inducers on neutrophil functions neutrophil chemiluminescence (ChL) was assayed on 31 healthy individuals, nine patients treated with IFN-Г┐ (human lymphoblastoid interferon, 3Б~10(6)units/day i. m. daily) and 11 patients treated with Ge-132 (2,250mg/day p. o. daily). The base lines (BLs), peak levels (PLs) and times to PLs (PLs) of neutrophil ChL were examined before, one week and one month after the treatment. The direct effects of IFN-Г┐, Ge-132 and OK-432 on neutrophil ChL were also evaluated by using an in vitro experimental system. PLs were significantly increased one week after the treatment with IFN-Г┐ or Ge-132. However, they were decreased to the pretreatment level one month after the treatment. In vitro experimental system IFN-Г┐ enhanced PLs of neutrophil ChL showing dose and time dependencies. On the other hand Ge-132 and OK-432 showed no direct effect on neutrophil ChL in vitro. These findings suggest that IFN-Г┐ and Ge-132 enhance the host defense mechanism by the activation of neutrophil functions, and also suggest that they have some benefits not only in the clinical management of cancer but also of chronic infection. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=ХЯЦ{МїНG kn-aut-sei=ХЯЦ{ kn-aut-mei=МїНG aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=Interferon kn-keyword=Interferon en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Ok-143 kn-keyword=Ok-143 en-keyword=Neutrophil Chemiluminescence kn-keyword=Neutrophil Chemiluminescence END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1135 end-page=1144 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of ANP secretion-atrial specific granules and hemodynamics kn-title=ANP ХкФхБ\ММНsУоС╘В╞У┴ОъшўЧ▒В╔К╓В╖ВщМЯУв en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify factors affecting atrial natriuretic peptide (ANP) secretion, the relationship between blood ANP level and intracardiac pressure, and that between the number of atrial specific granules (ASG) in the right atrial auricle and ANP level were investigated in 21 patients undergoing extracorporeal circulation. In the atrial loaded group, the Group TR (Tricuspid regurgitation) served as right atrial load and Group M (Mitral valve disease) as left atrial load, ANP and the number of ASG were compared with those in the control group. Accordingly, the effect of atrial load on ANP secretion and the number of ASG were investigated. Moreover, ANP and the number of ASG in the atrial myolysis group {Group A f(atrial fibrillation)} were compared with those of the sinus rhythm group to determine effect of atrio-myolysis. The ANP level showed a positive correlation with left atrial pressure (r=0.820 p<0.01) and with left ventricular end-diastolic pressure (r=0.726 p<0.01), but no correlation with right atrial pressure nor ventricular pressure. The ANP level in Group M was significantly higher than other groups, but there was no significant difference compared with Group TR. Consequently, the left atrium and rihgt atrium were considered to have different effects on ANP secretion. en-copyright= kn-copyright= en-aut-name=AsanoHirotaka en-aut-sei=Asano en-aut-mei=Hirotaka kn-aut-name=РєЦьНOНF kn-aut-sei=РєЦь kn-aut-mei=НOНF aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=У┴ОъшўЧ▒ kn-keyword=У┴ОъшўЧ▒ en-keyword=ANP kn-keyword=ANP en-keyword=ХкФхТ▓Р▀ kn-keyword=ХкФхТ▓Р▀ en-keyword=Н╢РSЦ[ kn-keyword=Н╢РSЦ[ en-keyword=ЙEРSЦ[ kn-keyword=ЙEРSЦ[ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=187 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An expert system for valvular heart disease using MRI and its clinical applications kn-title=РSСЯХ┘ЦМП╟В╠MRЙцСЬРfТfОxЙЗГVГXГeГАВ╠КJФнВ╞В╗В╠Ч╒П░ЙЮЧpВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=MRI is a valuable tool for diagnosing heart disease today. The cardiac blood flow is determined by an MRI image analysis and expert system. Image data are taken by a TV camera and digitalized. After gray level thresholding and region segmentation, the boundary of the regurgitant flow region is precisely extracted. Using this expert system, a doctor can easily make an accurate diagnosis of the valvular heart disease. This method should prove useful for the diagnosis of various heart diseases. en-copyright= kn-copyright= en-aut-name=NakagawaTomio en-aut-sei=Nakagawa en-aut-mei=Tomio kn-aut-name=ТЖРьХxХv kn-aut-sei=ТЖРь kn-aut-mei=ХxХv aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФХ·О╦Р№ИуКwЛ│О║ en-keyword=expert system kn-keyword=expert system en-keyword=MRI kn-keyword=MRI en-keyword=valvular heart disease kn-keyword=valvular heart disease END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=931 end-page=941 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thermographic findings as a prognostic indicator for breast cancer : Correlation between temperature increase and angioarchitecture kn-title=У√КрГTБ[ГВГOГЙГtиПКМйВ╞Ч\МуВ╠МЯУв;ГTБ[ГВГOГЙГtиВ╔ВиВпВщЙ╖УxПуП╕В╞ММК╟Н\ТzВ╠Х╧Й╗ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The thermographic findings of 191 patients with Satges I-III breast cancer were retrospectively evaluated to determine the prognostic indicators of disease-free survival in both the whole study population and in each histological stage. The angioarchitecture of 75 breast cancer specimens was subsequently examined morphometrically using an immunohistochemical method, and was then compared with the extent of increase in the temperature at the tumor site. The extent of increase in the temperature was more closely related to the prognosis than was the thermal pattern. In stage II cancer (n=57), patients with lesions that showed a temperature increase > 1.5БО had a poorer prognosis than the patients with hypothermic regions. (p<0.05). The range of skin temperature elevation at the tumor site correlated with the vascular changes in the skin above the tumor rather than with changes within or around the tumor in all of the patients. The increase in temperature above a tumor was concluded to be useful for assessing the prognosis and the grade of malignancy of breast cancer. The skin blood flow was also suggested to have the closest relationship with thermographic findings and the extent of the increase in blood flow to be a prognostic indicator for breast cancer. en-copyright= kn-copyright= en-aut-name=MurakamiMasakazu en-aut-sei=Murakami en-aut-mei=Masakazu kn-aut-name=С║ПуР│Шa kn-aut-sei=С║Пу kn-aut-mei=Р│Шa aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=Thermography kn-keyword=Thermography en-keyword=Breast cancer kn-keyword=Breast cancer en-keyword=Prognostic factor kn-keyword=Prognostic factor en-keyword=Malignant grade kn-keyword=Malignant grade en-keyword=Angioarchitecture kn-keyword=Angioarchitecture END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=923 end-page=929 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Combined resection of lung cancer and invaded aorta with the use of simple temporary bypass : A case reort kn-title=ФxКрВ╔ВиВпВщК╚И╒ОоИъОЮГoГCГpГXЦ@ВЁЧpВвВ╜СхУоЦмНЗХ╣Р╪ПЬВ╠ИъЧс en-subtitle= kn-subtitle= en-abstract= kn-abstract=Left pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57Б~43Б~35 mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch avobe the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0Б~3.0 cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60 mmHg during the operation. Local recurrence was observed 10 montns post-operatively, and the patient is now receiving radiation therapy. en-copyright= kn-copyright= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=ИфПуХ╢ФV kn-aut-sei=ИфПу kn-aut-mei=Х╢ФV aut-affil-num=1 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=ПуРьНNЦ╛ kn-aut-sei=ПуРь kn-aut-mei=НNЦ╛ aut-affil-num=2 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=ЧPЦ{Ч╟Хv kn-aut-sei=ЧPЦ{ kn-aut-mei=Ч╟Хv aut-affil-num=3 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=НЗТnЦ╛ kn-aut-sei=НЗТn kn-aut-mei=Ц╛ aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=Р▄УcМOОO kn-aut-sei=Р▄Уc kn-aut-mei=МOОO aut-affil-num=5 ORCID= en-aut-name=HataTakato en-aut-sei=Hata en-aut-mei=Takato kn-aut-name=ФиЧ▓Уo kn-aut-sei=Фи kn-aut-mei=Ч▓Уo aut-affil-num=6 ORCID= en-aut-name=KuinoseMasahiko en-aut-sei=Kuinose en-aut-mei=Masahiko kn-aut-name=НYГmРгП╣ХF kn-aut-sei=НYГmРг kn-aut-mei=П╣ХF aut-affil-num=7 ORCID= en-aut-name=NanbaHirofumi en-aut-sei=Nanba en-aut-mei=Hirofumi kn-aut-name=УяФgНGХ╢ kn-aut-sei=УяФg kn-aut-mei=НGХ╢ aut-affil-num=8 ORCID= en-aut-name=TaniguchiGyou en-aut-sei=Taniguchi en-aut-mei=Gyou kn-aut-name=ТJМ√ъЯ kn-aut-sei=ТJМ√ kn-aut-mei=ъЯ aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=6 en-affil= kn-affil=РSСЯХaГZГУГ^Б[НхМ┤ХaЙ@КOЙ╚ affil-num=7 en-affil= kn-affil=РSСЯХaГZГУГ^Б[НхМ┤ХaЙ@КOЙ╚ affil-num=8 en-affil= kn-affil=РSСЯХaГZГУГ^Б[НхМ┤ХaЙ@КOЙ╚ affil-num=9 en-affil= kn-affil=РSСЯХaГZГУГ^Б[НхМ┤ХaЙ@КOЙ╚ en-keyword=К╚И╒ОоИъОЮГoГCГpГX kn-keyword=К╚И╒ОоИъОЮГoГCГpГX en-keyword=СхУоЦмНЗХ╣Р╪ПЬ kn-keyword=СхУоЦмНЗХ╣Р╪ПЬ en-keyword=РiНsРлФxКр kn-keyword=РiНsРлФxКр END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=915 end-page=922 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy kn-title=ФxПмН╫ЦEКрЙ╗КwЧ├Ц@О└О{ЧсВ╔ВиВпВщПdХбКрВ╠ФнР╢В╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high. The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years. Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer. These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer. en-copyright= kn-copyright= en-aut-name=MiyakeKenichi en-aut-sei=Miyake en-aut-mei=Kenichi kn-aut-name=ОOСюМлИъ kn-aut-sei=ОOСю kn-aut-mei=МлИъ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=ФxПмН╫ЦEКр kn-keyword=ФxПмН╫ЦEКр en-keyword=Й╗КwЧ├Ц@ kn-keyword=Й╗КwЧ├Ц@ en-keyword=ПdХбКр kn-keyword=ПdХбКр END start-ver=1.4 cd-journal=joma no-vol=139 cd-vols= no-issue= article-no= start-page=83 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20081025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Support for those with person of advanced years through the making of ceramic kn-title=УйМ|РзНьВЁТ╩В╡В╜НВЧюО╥В╓В╠СвМ`КИУоОxЙЗ en-subtitle= kn-subtitle= en-abstract= kn-abstract=НВЧюЙ╗О╨ЙяВ┼ВаВщМ╗Н▌БAУ┴Х╩Ч{МьШVРlГzБ[ГАУЩНВЧюО╥С╬П█ХЯОГО{Р▌В╠ГjБ[ГYВкСЭЙ┴В╡В─ВвВщБBВ╗В▒В┼ХKЧvВ╞В│ВъВщХЯОГКИУоВ═БAУ·ПэР╢КИВ╠ЙюПХБAР╢КИЛєК╘В╠ТёЛЯВ╛ВпВ┼В═В╚ВнБAНВЧюО╥ВкВ╗ВъВ╝ВъО╨ЙяВЁН\РмВ╖ВщИъРlВ╞В╡В─С╕ПdВ│ВъБAО{Р▌УрКOВ╠РlВ╞МЁЧмВ╡БAЛдВ╔ОxВжВаВдГmБ[Г}ГЙГCГ[Б[ГVГЗГУВ╠О└СHВ┼ВаВщБBВ╗В╡В─БAРSЦLВйВ╚Р╢КИБAОйРgВ╠С╢Н▌ВкНmТшВ│ВъВщКИУоУЩБAГmБ[Г}ГЙГCГ[Б[ГVГЗГУВ╠О└СHВ╔ВиВвВ─ЧLЧpРлВ╠ВаВщР╢КUКwПKБuФ№ПpБvВ╓В╠К╓РSВ═Л▀ФNО╨ЙяУIВ╔НВВ▄В┴В─ВвВщБBЦ{НeВ┼В═БAВ▒В╠ВцВдВ╚ГmБ[Г}ГЙГCГ[Б[ГVГЗГУВ╠О└СHВЁЦ┌ОwВ╡В╜УйМ|ГПБ[ГNГVГЗГbГvВ╠КИУоУрЧeВ╔В┬ВвВ─ХёНРВ╡БAФSУyВ╞ВвВдРGКoС╠М▒КИУоВ┼У╛ВчВъВщГПБ[ГNГVГЗГbГvОQЙ┴О╥В╠РSВ╠Х╧Й╗ВЁМЯП╪В╖ВщБB en-copyright= kn-copyright= en-aut-name=UetaHisatoshi en-aut-sei=Ueta en-aut-mei=Hisatoshi kn-aut-name=ПуУcЛvЧШ kn-aut-sei=ПуУc kn-aut-mei=ЛvЧШ aut-affil-num=1 ORCID= en-aut-name=AbeTetutaro en-aut-sei=Abe en-aut-mei=Tetutaro kn-aut-name=ИвХФУSС╛ШY kn-aut-sei=ИвХФ kn-aut-mei=УSС╛ШY aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@Л│ИчКwМдЛЖЙ╚М|ПpЛ│ИчКwМnФ№ПpЛ│Ич affil-num=2 en-affil= kn-affil=Х║М╔МзЧзЙ┴М├РьУьНВУЩКwНZ en-keyword=ГtГ@ГVГКГeБ[Г^Б[ kn-keyword=ГtГ@ГVГКГeБ[Г^Б[ en-keyword=ГПБ[ГNГVГЗГbГv kn-keyword=ГПБ[ГNГVГЗГbГv en-keyword=УйМ| kn-keyword=УйМ| en-keyword=ГmБ[Г}ГЙГCГ[Б[ГVГЗГУ kn-keyword=ГmБ[Г}ГЙГCГ[Б[ГVГЗГУ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=1 article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microscopic Surface Change of Polycrystalline Aluminum duringTensile Plastic Deformation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Roughening on free surface of polycrystalline metal during plastic deformation is closely related to the inhomogeneous deformation in the respective grain at the surface. Uniaxial tensile tests are carried out on annealed pure aluminum sheet specimens with various averaged grain sizes. The roughening is measured by a 3-dimensional stylus instrument to examine the roughness change in both sides of specimen surfaces at each strain. The irregularities on one side are reversed on the backside, when the averaged grain size is as large as the thickness of the specimen. Discussions are made on the relation between the surface shapes of both sides adopting the cross correlation factor. The strains of respective grains are also measured from the grain boundary shape before and after plastic deformation. There are some deviations in the strains of the grains and their standard deviation increases with the applied strain. en-copyright= kn-copyright= en-aut-name=WangXiaoqun en-aut-sei=Wang en-aut-mei=Xiaoqun kn-aut-name=ЙдЛ┼МQ kn-aut-sei=Йд kn-aut-mei=Л┼МQ aut-affil-num=1 ORCID= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name=ИвХФХРОб kn-aut-sei=ИвХФ kn-aut-mei=ХРОб aut-affil-num=2 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name=С╜УcТ╝Н╞ kn-aut-sei=С╜Уc kn-aut-mei=Т╝Н╞ aut-affil-num=3 ORCID= en-aut-name=ShimizuIchiro en-aut-sei=Shimizu en-aut-mei=Ichiro kn-aut-name=Р┤РЕИъШY kn-aut-sei=Р┤РЕ kn-aut-mei=ИъШY aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=2 en-affil= kn-affil=Tsuyama College of Technology affil-num=3 en-affil= kn-affil=Dept. of Mechanical Engineering Okayama University affil-num=4 en-affil= kn-affil=Dept. of Mechanical Engineering Okayama University END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=1 article-no= start-page=16 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=RNN Based Auto-tuning of PID Control Gains in Hot StripLooper Controller en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, auto tuning of PID control gains in hot strip looper controller is made based on RNN model. Neuro emulator is employed to model the characteristics of looper dynamics. Combining neuro emulator and RNN model, auto tuning system of PID control gains is constructed. As the inputs to RNN, plural evaluation functions which reflect individual preference of human experts. Further, Self learning mechamism is embeded to RNN model which enables adaptation to the change in rolling chracteristics. Through numerical experiments, the effect of the proposed method is ascertained. en-copyright= kn-copyright= en-aut-name=AbeYoshihiro en-aut-sei=Abe en-aut-mei=Yoshihiro kn-aut-name=ИвХФЙїЧm kn-aut-sei=ИвХФ kn-aut-mei=ЙїЧm aut-affil-num=1 ORCID= en-aut-name=KonishiMasami en-aut-sei=Konishi en-aut-mei=Masami kn-aut-name=ПмР╝Р│чZ kn-aut-sei=ПмР╝ kn-aut-mei=Р│чZ aut-affil-num=2 ORCID= en-aut-name=NishiTatsushi en-aut-sei=Nishi en-aut-mei=Tatsushi kn-aut-name=Р╝Ч│Оu kn-aut-sei=Р╝ kn-aut-mei=Ч│Оu aut-affil-num=3 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name=НбИфПГ kn-aut-sei=НбИф kn-aut-mei=ПГ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Dept. of Electrical and Electronic Engineering Okayama University affil-num=2 en-affil= kn-affil=Dept. of Electrical and Electronic Engineering Division of Industrial Innovation Sciences The Graduate School of Natural Science and Technology Okayama University affil-num=3 en-affil= kn-affil=Dept. of Electrical and Electronic Engineering Division of Industrial Innovation Sciences The Graduate School of Natural Science and Technology Okayama University affil-num=4 en-affil= kn-affil=Dept. of Electrical and Electronic Engineering Division of Industrial Innovation Sciences The Graduate School of Natural Science and Technology Okayama University END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=475 end-page=487 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Flow cytometric DNA analysis in thyroid tumors kn-title=НbПєСBОюсЗВ╠КjDNAЧ╩В╞Р╢ХиКwУIИлРлУxВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate the biological malingnacy of differentiated thyroid cancer, we determined the nuclear DNA content in thyroid tumors by flow cytometry using paraffin-enbedded materials. The subjects were 80 patients with thyroid tumors. The thyroid tumors were follicular adenoma in 11 cases and thyroid cancer in 69 cases. Of the 69 cases of thyroid cancer, 42 were histologically classfied as papillary carcinoma, 18 as follicular carcinoma, 3 as medullary carcinoma and 6 as anaplastic carcinoma. DNA ploidy pattern and the percentage of proliferating phase cells were analyzed in relation to the prognosis and the following clinicopathological findings : age, gender, histological type, tumor size (t), extrathyroidal invasion (Ex), lymph node metastases (n) and distant metastases (M). DNA ploidy pattern correlated with histological type (p<0.005), but did not correlate with other clinicopathological findings. The percentage of prolipherating phase cells correlated with age (p<0.01) and the histlogical type (p<0.05), but did not correlate with other clinicopathological findings. The percentage of proliferating phase cells correlated with age (p<0.01) and the histological type (p<0.05), but did not correlate with other clinicopathological findings. The comulative survival rate (Kaplan- Meier) of differentiated carcinomas was worse in the aneuploid group than in the diploid group (p<0.0001). the percentage of proliferaging phase cells increased as the prognosis deteriorated. The results suggest that flow cytometric DNA analysis may be useful to evaluate biological malignancy of thyroid tumors. en-copyright= kn-copyright= en-aut-name=OnodaYuji en-aut-sei=Onoda en-aut-mei=Yuji kn-aut-name=ПмЦьУcЧTОm kn-aut-sei=ПмЦьУc kn-aut-mei=ЧTОm aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёКOЙ╚КwЛ│О║ en-keyword=НbПєСBКр kn-keyword=НbПєСBКр en-keyword=ГtГНБ[ГTГCГgГБГgГКБ[ kn-keyword=ГtГНБ[ГTГCГgГБГgГКБ[ en-keyword=Р╢ХиКwУIИлРлУx kn-keyword=Р╢ХиКwУIИлРлУx en-keyword=ГvГНГCГfГBГpГ^Б[ГУ kn-keyword=ГvГНГCГfГBГpГ^Б[ГУ en-keyword=СЭРBК·Н╫ЦE kn-keyword=СЭРBК·Н╫ЦE END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=299 end-page=304 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of broncholithiasis complicating hemoptysis kn-title=Ъ\ММВЁОхСiВ╔ЧИЙ@В╡В╜ЛCК╟ОxМЛР╬В╠1Чс en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 62-year-old male was admitted because of hemoptysis. The chest X-ray showed an infiltrative shadow in the right upper lung field. Tomograms and CT scans also showed an infiltrative shadow and small calcifications in the same field. Examination by bronchoscopy revealed bronchial bleeding from the depth of the right B1b. Although the detailed view was unclear due to bleeding, we did not find any growth or any mucosal abnormality. We examined only the bronchial washing cytology. The result was Papanicolaou class ЗU. However, we could not rule out malignancy, so we decided to perform a right upper lobectomy. A bron-cholith was seen in the B1b and a hematoma was also seen on its periphery. The stone components were calcium carbonate (74%) and calcium phosphate (26%), suggesting that the stone was caused by mucus retention. en-copyright= kn-copyright= en-aut-name=IshiiYasunori en-aut-sei=Ishii en-aut-mei=Yasunori kn-aut-name=Р╬ИфС╫Се kn-aut-sei=Р╬Иф kn-aut-mei=С╫Се aut-affil-num=1 ORCID= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=ИфПуХ╢ФV kn-aut-sei=ИфПу kn-aut-mei=Х╢ФV aut-affil-num=2 ORCID= en-aut-name=ShinRyuhan en-aut-sei=Shin en-aut-mei=Ryuhan kn-aut-name=РTЧ▓Ф═ kn-aut-sei=РT kn-aut-mei=Ч▓Ф═ aut-affil-num=3 ORCID= en-aut-name=IshizukaShinji en-aut-sei=Ishizuka en-aut-mei=Shinji kn-aut-name=Р╬Т╦Р^Ож kn-aut-sei=Р╬Т╦ kn-aut-mei=Р^Ож aut-affil-num=4 ORCID= en-aut-name=FunakiNaoto en-aut-sei=Funaki en-aut-mei=Naoto kn-aut-name=ПMЦ╪Т╝Рl kn-aut-sei=ПMЦ╪ kn-aut-mei=Т╝Рl aut-affil-num=5 ORCID= en-aut-name=MuramatsuTomoyoshi en-aut-sei=Muramatsu en-aut-mei=Tomoyoshi kn-aut-name=С║П╝ЧFЛ` kn-aut-sei=С║П╝ kn-aut-mei=ЧFЛ` aut-affil-num=6 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=ПуРьНNЦ╛ kn-aut-sei=ПуРь kn-aut-mei=НNЦ╛ aut-affil-num=7 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=УcТЖЛIП═ kn-aut-sei=УcТЖ kn-aut-mei=ЛIП═ aut-affil-num=8 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=Р▄УcМOОO kn-aut-sei=Р▄Уc kn-aut-mei=МOОO aut-affil-num=9 ORCID= en-aut-name=OdaKoji en-aut-sei=Oda en-aut-mei=Koji kn-aut-name=ПмУcЭьУё kn-aut-sei=ПмУc kn-aut-mei=ЭьУё aut-affil-num=10 ORCID= en-aut-name=SeoKenji en-aut-sei=Seo en-aut-mei=Kenji kn-aut-name=РгФЎМЫОб kn-aut-sei=РгФЎ kn-aut-mei=МЫОб aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=6 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=7 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=8 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=9 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=10 en-affil= kn-affil=ПмУcХaЙ@КOЙ╚ affil-num=11 en-affil= kn-affil=МТП╞ЙяГZГIХaЙ@ en-keyword=ЛCК╟ОxМЛР╬ kn-keyword=ЛCК╟ОxМЛР╬ en-keyword=Ъ\ММ kn-keyword=Ъ\ММ en-keyword=Broncholithiasis kn-keyword=Broncholithiasis en-keyword=Hemoptysis kn-keyword=Hemoptysis END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=919 end-page=932 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Superoxide anion (O(2)(Б|)) production by neutrophils in myelodysplastic syndrome (MDS) kn-title=Myelodysplastic syndrome (MDS) В╔ВиВпВщНDТЖЛЕГXБ[ГpБ[ГIГLГTГCГhОYР╢Ф\В╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Myelodysplastic syndrome (MDS) are hematological disorders with the potential of progressing to acute leukemia. MDS patients occasionally die of infection despite the absence of severe pancytopenia prior to overt leukemia. Superoxide anion (O(2)(Б|)) production leads to intracellular bactericidal activity by neutrophils, particularly in an oxygen-dependent system. In this paper, O(2)(Б|) production by neutrophils in 15 MDS patients [11 patients with refractory anemia with excess of blasts (RAEB) and 4 patients with RAEB in transformation (RAEB-t)] was examined to evaluate possible causes of enhanced susceptibility to infection and to gain information concerning the pathophysiology and prognosis. The following results were obtained : (1) The O(2)(Б|) production by neutrophils (O(2)(Б|) production) in 15 MDS patients was lower than that in healthy controls (3.75Б}2.93 vs 6.20Б}1.53 nmol/min/10(6) neutrophils, p<0.05). Three of the 15 MDS patients showed little O(2)(Б|) production. (2) There was inverse correlation between O(2)(Б|) production and the percentage of leukemic cells in the marrow in acute leukemia (r=0.55, p<0.01), but not in MDS. (3) The O(2)(Б|) production in 5 MDS patients showing morphological anomalies in a high percentage of neutrophils significantly lower than that in 10 MDS patients showing morphological anomalies in a low percentage of neutrophils (1.04Б}1.37 vs 5.15Б}2.50 nmol/min/10(6) neutrophils, p<0.05). (4) The O(2)(Б|) production in 5 patients with frequent fever (БЖ38БО) -episodes was significantly lower than that in 10 MDS patients with infrequent fever-episodes (2.22Б}2.15 vs 4.49Б}2.83 nmol/min 10(6) neutrophils, p<0.05). (5) Comparison of the O(2)(Б|) production between MDS patients with and without progression to overt leukemia showed no significant difference (4.25Б}3.26 vs 3.28Б}2.76 nmol/min/10(6) neutrophils). These findings suggest that impaired O(2)(Б|) production by neutrophils, probably due to the faulty differentiation from abnormal hematopoietic clones, is one possible cause of enhanced susceptibility to infection in MDS, and may provide clues for clinical management of infection, but is not useful for early detection of progression to overt leukemia. en-copyright= kn-copyright= en-aut-name=InagakiNoritoshi en-aut-sei=Inagaki en-aut-mei=Noritoshi kn-aut-name=ИюК_УoЦл kn-aut-sei=ИюК_ kn-aut-mei=УoЦл aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=superoxide anion kn-keyword=superoxide anion en-keyword=myelodysplastic syndrome (MDS) kn-keyword=myelodysplastic syndrome (MDS) END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=903 end-page=918 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Leukemic cell destruction kinetics in bone marrow kn-title=Л}РлФТММХaК░ЙЁУ▒У№Ч├Ц@В╔ВиВпВщНЬРСУрФТММХaН╫ЦEМ╕ПнУоС╘В╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=An equation was developed to describe the kinetics of leukemic cell destruction in bone marrow during induction chemotherapy for acute nonlymphocytic leukemia (logZББK(1)t(4)Б{K(2)t(3)Б{K(3)t(2)Б{K(4), where ZББleukemic cell number, tББtime, and KББa constant). The leukemic cell destruction curve was biphasic ; phase ЗT was the period from the initiation of a decrease in cells to the maximum velocity of the decrease, and phase ЗU was the subsequent period to the cessation of decrease. The following parameters were established : duration and acceleration of decrease in phases ЗT and ЗU, maximum velocity of decrease, duration of reduction, and residual volume of leukemic cells. 1. Patients who achieved CR showed a longer duration of phases ЗT and ЗU, a lower acceleration of the decrease in phase ЗU, and smaller residual leukemic cell volume than patients who did not achieve CR. there were no significant differences of parameters related to FAB classification, type of induction therapy, or the age of the patients. 2. This equation could be adapted to explain erythroblast kinetics during induction chemotherapy. There were no significant differences of the parameters with respect to the effect of induction therapy and patient age. 3. Patients with high acceleration of the decrease in phase ЗU had a short duration of CR and survival. The leukemic cell destruction curve was thought to be useful not only for evaluation of the effect of induction therapy, but also for establishment of post-remission chemotherapy. en-copyright= kn-copyright= en-aut-name=TakeuchiMakoto en-aut-sei=Takeuchi en-aut-mei=Makoto kn-aut-name=Т|УрР╜ kn-aut-sei=Т|Ур kn-aut-mei=Р╜ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=acute leukemia kn-keyword=acute leukemia en-keyword=leukemic cell destruction curve kn-keyword=leukemic cell destruction curve en-keyword=leukemic cell destruction kinetics kn-keyword=leukemic cell destruction kinetics en-keyword=remission induction chemotherapy kn-keyword=remission induction chemotherapy END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=3 article-no= start-page=313 end-page=320 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20081201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=XV Radiotherapy kn-title=XV Х·О╦Р№ОбЧ├ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakemotoMitsuhiro en-aut-sei=Takemoto en-aut-mei=Mitsuhiro kn-aut-name=ХРЦ{П[НL kn-aut-sei=ХРЦ{ kn-aut-mei=П[НL aut-affil-num=1 ORCID= en-aut-name=KatayamaNorihisa en-aut-sei=Katayama en-aut-mei=Norihisa kn-aut-name=Х╨ОRМhЛv kn-aut-sei=Х╨ОR kn-aut-mei=МhЛv aut-affil-num=2 ORCID= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name=ПЯИфЦMП▓ kn-aut-sei=ПЯИф kn-aut-mei=ЦMП▓ aut-affil-num=3 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name=ЛррVЙE kn-aut-sei=ЛррV kn-aut-mei=ЙE aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФБEОХКwХФХНСоХaЙ@Б@Х·О╦Р№Й╚ affil-num=2 en-affil= kn-affil=ЙкОRСхКwИуКwХФБEОХКwХФХНСоХaЙ@Б@Х·О╦Р№Й╚ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФБEОХКwХФХНСоХaЙ@Б@Х·О╦Р№Й╚ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФБEОХКwХФХНСоХaЙ@Б@Х·О╦Р№Й╚ en-keyword=Х·О╦Р№ОбЧ├ kn-keyword=Х·О╦Р№ОбЧ├ en-keyword=Х·О╦Р№Ч├Ц@ kn-keyword=Х·О╦Р№Ч├Ц@ en-keyword=radiotherapy kn-keyword=radiotherapy en-keyword=radiation therapy kn-keyword=radiation therapy en-keyword=irradiation kn-keyword=irradiation END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=73 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 1. Comparison of antitumor activity of anthracycline-anthraquinone analogues in human lung cancer cell lines kn-title=Colony assay Ц@ВЁЧpВвВ╜ФxКрЙ╗КwЧ├Ц@В╔ВиВпВщ Anthracycline-anthraquinone МnЦЄН▄В╠ЧLМ°РлВ╔К╓В╖ВщМдЛЖ Сц1Х╥ ГqГgФxКрН╫ЦEКФВ╔С╬В╖Вщ Anthracycline-anthraquinone МnЦЄН▄В╠ОEН╫ЦEМ°Й╩В╠ФфКr en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate the antitumor activity of new anthracycline-anthraquinone analogues ; aclarubicin (ACR), tetrahydropyranyl adriamycin (THP-ADM), and mitoxantrone(MIT), these analogues were compared with adriamycin(ADM) in terms of 70% lethal dose by colony assay using five human lung cancer cell lines, which had been established and maintained in our laboratory. The human lung cancer cell lines tested were EBC-1, an epidermoid cancer cell line, ABC-1, an adenocarcinoma cell line, and SBC-1, -2, and -3, small cell cancer cell lines. In general, the EBC-1 established from a patient tumor showing resistance to ADM was the least sensitive to the drugs tested, and SBC-3 established from a patient tumor with no prior chemotherapy was the most sensitive to the drugs. In antitumor activity, both ACR and THP-ADM appeared to be superior to ADM and MIT, suggesting the clinical usefulness of these drugs in the treatment of lung cancer. en-copyright= kn-copyright= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name=П└УcМТФV kn-aut-sei=П└Уc kn-aut-mei=МТФV aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцУёУрЙ╚КwЛ│О║ en-keyword=ФxКрН╫ЦEКФ kn-keyword=ФxКрН╫ЦEКФ en-keyword=colony assay kn-keyword=colony assay en-keyword=anthracycline kn-keyword=anthracycline en-keyword=anthraquinone kn-keyword=anthraquinone END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=771 end-page=778 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Flowcytometric studies of effects of heat on DNA synthesis in different thermosensitivities mammalian cell lines kn-title=Й╖ФMК┤ОєРлВ╠И┘В╚ВщФ|Ч{Н╫ЦEВ╠ DNA НЗРмВ╔С╬В╖ВщЙ╖ФMМ°Й╩Б\ГtГНБ[ГTГCГgГБГgГКБ[В╔ВцВщМдЛЖБ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of heat on DNA synthesis in HeLa S3 cells and L-5 cells was studied using flowcytometry. When D(0) values obtained from survival curves of Ehrlich ascites tumor cells, L-5 cells, HeLa S3 cells and NIH3T3 cells after heating to 43, 44, or 45БО, were compared, HeLa S3 cells were resistant and L-5 cells were sensitive to heating. During heating at 43БО, DNA synthesis (BUdR uptake) of HeLa S3 cells was resistant compared to that of L-5 cells. When the period of DNA synthesis was divided into 3 fractions (early S, mid S and late S), late S phase was the most sensitive fraction to heating at 43БО for 60 minutes. From these results, relationship between DNA synthesis and thermocytotoxic effects are discussed. en-copyright= kn-copyright= en-aut-name=TanakaSeiryou en-aut-sei=Tanaka en-aut-mei=Seiryou kn-aut-name=УcТЖР╣Ч╣ kn-aut-sei=УcТЖ kn-aut-mei=Р╣Ч╣ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФХ·О╦Р№ИуКwЛ│О║ en-keyword=Flowcytometry kn-keyword=Flowcytometry en-keyword=DNA synthesis kn-keyword=DNA synthesis en-keyword=Heating kn-keyword=Heating en-keyword=BUdR kn-keyword=BUdR END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=11-12 article-no= start-page=1125 end-page=1142 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Possible anti-tumor effects of drug-induced splenectomy with cyclophosphamide and indomethacin, and surgical splenectomy in combination with immunochemotherapy in tumor-bearing mice and gastric cancer patients kn-title=ТSКрГ}ГEГXВ╚ВчВ╤В╔И▌КрК│О╥В╔ВиВпВщ Cyclophosphamide В╞ Indomethacin В╔ВцВщЦЄХиКwУIУEфBМ°Й╩В╠Й┬Ф\РлБCВиВцВ╤КOЙ╚УIУEфBВ╞Ц╞ЙuЙ╗КwЧ├Ц@Х╣ЧpВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using tumor-bearing C(3)H/He mice, in which syngeneic MH-134 tumor cells were transplanted into the back subcutaneously, the possibility of drug-induced splenectomy using cyclophosphamide (CY) and indomethacin (INDO), the timing of chemo- and immuno-therapy, and the usefulness of the combination of surgical splenectomy with immunotherapy were investigated. In patients with gastric cancer, the significance of splenectomy and its combination with immunochemotherapy was also studied. The administration of CY in mice on day 3 after tumor transplantation in the initial stage of the tumor prolonged the survival time, while INDO under the same condition shortened it only when administered on day 3 after transplantation. The administration of an immunopotentiator, OK-432, prior to CY administration shortened the survival time, compared with that of single administration of CY, whereas the OK-432 administration on day 2 after the administration of CY prolonged the survival time. In the immunochemotherapy in which CY was administered on day 7 after transplantation of tumor and OK-432 was given every two days after additional 2 days, the anti-tumor effect of drug-induced splenectomy was not observed as judged from the tumor proliferating curve, but the splenectomy on day 3 after tumor transplantation, in the initial stage of the tumor, prolonged tne survival time. Similar results were observed, when INDO was used instead of CY. The concomitant splenectomy in the initial stage of gastric cancer resulted in a more effective prolongation of survival time. In the cases with adjuvant immunochemotherapy, preservation of the spleen in advanced cancer and splenectomy in the terminal stage of cancer were found to be preferable for effective prolongation of the survival time. en-copyright= kn-copyright= en-aut-name=YuiJiro en-aut-sei=Yui en-aut-mei=Jiro kn-aut-name=ЧRИфОбШY kn-aut-sei=ЧRИф kn-aut-mei=ОбШY aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ en-keyword=ЦЄХиКwУIУEфB kn-keyword=ЦЄХиКwУIУEфB en-keyword=cyclophosphamide kn-keyword=cyclophosphamide en-keyword=indomethacin kn-keyword=indomethacin en-keyword=УEфBВ╞Ц╞ЙuЧ├Ц@ kn-keyword=УEфBВ╞Ц╞ЙuЧ├Ц@ en-keyword=УEфBВ╞Ц╞ЙuЙ╗КwЧ├Ц@ kn-keyword=УEфBВ╞Ц╞ЙuЙ╗КwЧ├Ц@ END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=1003 end-page=1012 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Heart rate response during face immersion test to evaluate autonomic nervous function : The responses of normal subjects compared to those of diabetic patients kn-title=ОйЧеР_МoЛ@Ф\МЯН╕В╞В╡В─В╠КчЦ╩РZРЕХЙЙ╫ГeГXГgВ╠ЧLЧpРлВ╠МЯУвБ\УЬФAХaК│О╥В╞МТПэРlВ╔ВиВпВщРSФПХ╧УоРлВ╠ФфКrМЯУвБ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We examined the heart rate response to face immesion in 17 normal subjects and 9 diabetics. The subjects immersed their face fully in a basin filled with ice water at 4-6БО in a foward leaning position for 20 sec. Two-lead electrocardiogram (ECG) was continuously recorded from 20 sec before the immersion to 5 min after. The R-R intervals were measured on the recorded ECG. In the control group, heart rate response to face immesion showed 4 pahses : an initial increment after the immersion of the face (phase 1), decrease after the initial increment (phase 2), second increment after phase 2 (phase 3) and second decrease after the second increment (phase 4). Repeated face immersion test with a 10 min interval revealed reproducibility of the test. Parasympathetic blockade with atropine sulphate attenuated the pahse 2 response, suggenting that cardiac parasympathetic nerve tone increases in response to the initial increment in the heart rate due to sympathetic response. In diabetic patients, phase 2 response was reduced in patients with a shorter history of diabetes, while in patients with a longer history, heart rate response was diminishied in all phases. Therefore, heart rate response to face immersion was attenuated relative to the duration of the illness. The present study suggests that the analysis of the heart rate response to face immersion in useful as an autonomic nervous function test. en-copyright= kn-copyright= en-aut-name=HonmaNana en-aut-sei=Honma en-aut-mei=Nana kn-aut-name=Ц{К╘Н╪БX kn-aut-sei=Ц{К╘ kn-aut-mei=Н╪БX aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъУрЙ╚КwЛ│О║ en-keyword=ОйЧеР_МoЛ@Ф\МЯН╕ kn-keyword=ОйЧеР_МoЛ@Ф\МЯН╕ en-keyword=УЬФAХaРлР_МoПсКQ kn-keyword=УЬФAХaРлР_МoПсКQ en-keyword=РSФПХ╧Уо kn-keyword=РSФПХ╧Уо END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=939 end-page=946 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic cholecystectomy in patients with nonvisualizing gallbaldder by DIC and previous upper abdominal surgery kn-title=DICТ_ФXЙAРлЧсВиВцВ╤ПуХаХФКJХаК∙ЙЭП╟ЧсВ╔С╬В╖ВщХаНoЛ╛Й║Т_ФXУEПoПpВ╠МЯУв en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between July 1991 and December 1993, 80 patients with gallstone and/or gallbladder polyp were considered candidates for laparoscopic cholecystectomy. We attempted 7 cases of laparoscopic cholecystectomy for patients with nonvisualizing gallbladder by DIC, and in 6 cases, the laparoscopic cholecystectomy was successfully completed. In the remaining 1 case the operation was converted to open cholecystectomy due to severe acute cholecystitis. During the same period, there were 8 patients who had previous upper abdominal surgery, and in 4 of these patients, laparoscopic cholecystectomy was successfully completed. All patients were free of major complications intra and postoperatively. We can extend the indications for laparoscopic cholecystectomy as skill with this procedure increases. We believe that this procedure will become the standard operation for benign gallbladder diseases in the near future in Japan. en-copyright= kn-copyright= en-aut-name=KondoHidenori en-aut-sei=Kondo en-aut-mei=Hidenori kn-aut-name=Л▀УбПGСе kn-aut-sei=Л▀Уб kn-aut-mei=ПGСе aut-affil-num=1 ORCID= en-aut-name=OkitsuTeru en-aut-sei=Okitsu en-aut-mei=Teru kn-aut-name=Л╗Т├ЛP kn-aut-sei=Л╗Т├ kn-aut-mei=ЛP aut-affil-num=2 ORCID= en-aut-name=KondoMasami en-aut-sei=Kondo en-aut-mei=Masami kn-aut-name=Л▀УбР│Ф№ kn-aut-sei=Л▀Уб kn-aut-mei=Р│Ф№ aut-affil-num=3 ORCID= en-aut-name=TsugeHiromu en-aut-sei=Tsuge en-aut-mei=Hiromu kn-aut-name=Т├Й║НG kn-aut-sei=Т├Й║ kn-aut-mei=НG aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=Р▄УcМOОO kn-aut-sei=Р▄Уc kn-aut-mei=МOОO aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=2 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=3 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚КwЛ│О║ en-keyword=DIC Т_ФXЙAРлЧс kn-keyword=DIC Т_ФXЙAРлЧс en-keyword=ПуХаХФКJХаК∙ЙЭП╟Чс kn-keyword=ПуХаХФКJХаК∙ЙЭП╟Чс en-keyword=ХаНoЛ╛Й║Т_ФXУEПoПp kn-keyword=ХаНoЛ╛Й║Т_ФXУEПoПp END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=771 end-page=778 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic cholecystectomy : Our experience of 75 consecutive cases kn-title=ХаНoЛ╛Й║Т_ФXУEПoПp75ЧсВ╠МoМ▒ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We peformed 75 consecutive laparoscopic cholecystectomy from July 1991 to October 1993 on the patients with gallstones and/or gallbladder polyps. The patients consisted of 30 males and 45 females between 32 and 88 years old with a mean age of 59.4 years. In 72 of these 75 patients (96.0%) laparoscopic cholecystectomy was successfully completed. In the remaining 3 cases (4.0%) the operation was converted to the open cholecystectomy. All patients were free of major complications. Three patients required conversion to a conventional open cholecystectomy due to fallen gallstones in the peritoneal cavity, dense adhesions surrounding the gallbladder and severe acute cholecystitis. This procedure is advantageous in comparison with the conventional open cholecystectomy, because of less postoperative pain, rapid postoperative recovery and high cosmetic value as well. Laparoscopic cholecystectomy seems to be a safe and effective treatment for selected patients with benign gallbladder diseases. en-copyright= kn-copyright= en-aut-name=KondoHidenori en-aut-sei=Kondo en-aut-mei=Hidenori kn-aut-name=Л▀УбПGСе kn-aut-sei=Л▀Уб kn-aut-mei=ПGСе aut-affil-num=1 ORCID= en-aut-name=OkitsuTeru en-aut-sei=Okitsu en-aut-mei=Teru kn-aut-name=Л╗Т├ЛP kn-aut-sei=Л╗Т├ kn-aut-mei=ЛP aut-affil-num=2 ORCID= en-aut-name=KondoMasami en-aut-sei=Kondo en-aut-mei=Masami kn-aut-name=Л▀УбР│Ф№ kn-aut-sei=Л▀Уб kn-aut-mei=Р│Ф№ aut-affil-num=3 ORCID= en-aut-name=TsugeHiromu en-aut-sei=Tsuge en-aut-mei=Hiromu kn-aut-name=Т├Й║НG kn-aut-sei=Т├Й║ kn-aut-mei=НG aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=Р▄УcМOОO kn-aut-sei=Р▄Уc kn-aut-mei=МOОO aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=2 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=3 en-affil= kn-affil=Л▀УбХaЙ@КOЙ╚ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚Л│О║ affil-num=5 en-affil= kn-affil=ЙкОRСхКwИуКwХФСцИъКOЙ╚Л│О║ en-keyword=ХаНoЛ╛Й║Т_ФXУEПoПp kn-keyword=ХаНoЛ╛Й║Т_ФXУEПoПp en-keyword=Т_Р╬П╟ kn-keyword=Т_Р╬П╟ en-keyword=Т_ФXГ|ГКБ[Гv kn-keyword=Т_ФXГ|ГКБ[Гv END start-ver=1.4 cd-journal=joma no-vol=110 cd-vols= no-issue=11-12 article-no= start-page=171 end-page=210 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Peritoneal dissemination caused by ovarian teratoma-Especially teratomatosis peritonei-from clinicopathalogical research on 156 cases of this century kn-title=Teratomatosis PeritoneiБ\ЧССГКяМ`ОюЧRЧИВ╠ХаЦМФdОэРлХaСГВ╔К╓В╖ВщХ╢МгКwУIНlО@БFНбРвЛIХёНРВ│ВъВ╜156ЧсВ╠Ч╒П░ХaЧЭКwУIМЯУвВ╔ВцВщПWСхРмБ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We performed clinicopathological analyses of peritoneal dissemination caused by ovarian teratoma (PD caused by OV-T), on the English great table of 156 cases in 105 papers published in this century. We classified PD caused by OV-T into 3 categories as follows ; 1. (TP) teratomatosis peritonei (new term) : PD composed by three germ teratomas cells. 2. (GP) gliomatosis peritonei : PD composed by only glia cells. 3. (MIX) mixed type : PD composed by glia and teratoma cells. TP and MIX were newly designated in this present paper. The number of TP, GP and MIX were 22, 95 and 25, respectively. The review of these 156 cases and 105 papers were demonstrated that the clinical features between GP and TP were cleary different. TP had a more tendency of recurrentn character in comparison to GP and MIX, but had a good long survivals resulted by repeated surgical resections. en-copyright= kn-copyright= en-aut-name=KobayashiMasanao en-aut-sei=Kobayashi en-aut-mei=Masanao kn-aut-name=ПмЧ╤Р│Т╝ kn-aut-sei=ПмЧ╤ kn-aut-mei=Р│Т╝ aut-affil-num=1 ORCID= en-aut-name=KobayashiJun-ichi en-aut-sei=Kobayashi en-aut-mei=Jun-ichi kn-aut-name=ПмЧ╤П~Иъ kn-aut-sei=ПмЧ╤ kn-aut-mei=П~Иъ aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=КтК_ФОЦд kn-aut-sei=КтК_ kn-aut-mei=ФОЦд aut-affil-num=3 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=УcТЖЛIП═ kn-aut-sei=УcТЖ kn-aut-mei=ЛIП═ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ПмЧ╤ХaЙ@Б@КOЙ╚ affil-num=2 en-affil= kn-affil=ПмЧ╤ХaЙ@Б@КOЙ╚ affil-num=3 en-affil= kn-affil=ЙкОRСхКwИуКwХФКOЙ╚КwСцИъНuН└ affil-num=4 en-affil= kn-affil=ЙкОRСхКwИуКwХФКOЙ╚КwСцИъНuН└ en-keyword=ovarian teratoma kn-keyword=ovarian teratoma en-keyword=peritoneal dissemination kn-keyword=peritoneal dissemination en-keyword=teratomatosis peritonei kn-keyword=teratomatosis peritonei en-keyword=gliomatosis peritonei kn-keyword=gliomatosis peritonei END start-ver=1.4 cd-journal=joma no-vol=110 cd-vols= no-issue=7-10 article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19981030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Case report of a gastric glomus tumor kn-title=И▌КрВЁФ║В┴В╜И▌ГOГНБ[ГАГXОюсЗВ╠1ЧсБ\Ц{ЦMХёНРЧсВ╠Х╢МгУIНlО@Б\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The patient was a 67-year-old man who vomitted blood during therapy while hospitalized due to an asthma attack. He underwent a gastric examination, which detected a submucosal tumor on the greater curvature of the gastric antrum and gastric cancer on the lesser curvature. This tumor was diagnosed as a glomus tumor by postoperative pathological examination. In Japan, glomus tumors of stomach have been reported in 50 cases including our case. The mean age of patients was 48 years (23 to 74). Nineteen patients were male and 31 female. The main symptom was upper abdominal pain. The tumors developed in the submucosal layer of the greater curvature in the antrum and the mean size was 2.8 cm. A Angiography revealed hypervascularization and endoscopic ulutasonography showed spheroid tumors localized in the muscle layer. Proeoperative histological diagnoses were often difficult. Two cases including our patient were associated with gastric cancer. en-copyright= kn-copyright= en-aut-name=FukudaKazuma en-aut-sei=Fukuda en-aut-mei=Kazuma kn-aut-name=ХЯУcШaФn kn-aut-sei=ХЯУc kn-aut-mei=ШaФn aut-affil-num=1 ORCID= en-aut-name=AsanoHiroaki en-aut-sei=Asano en-aut-mei=Hiroaki kn-aut-name=РєЦьФОП║ kn-aut-sei=РєЦь kn-aut-mei=ФОП║ aut-affil-num=2 ORCID= en-aut-name=OtaniYuu en-aut-sei=Otani en-aut-mei=Yuu kn-aut-name=СхТJЧT kn-aut-sei=СхТJ kn-aut-mei=ЧT aut-affil-num=3 ORCID= en-aut-name=MiyagutiNaoyuki en-aut-sei=Miyaguti en-aut-mei=Naoyuki kn-aut-name=Л{М√Т╝ФV kn-aut-sei=Л{М√ kn-aut-mei=Т╝ФV aut-affil-num=4 ORCID= en-aut-name=NishiHideyuki en-aut-sei=Nishi en-aut-mei=Hideyuki kn-aut-name=Р╝ЙpНs kn-aut-sei=Р╝ kn-aut-mei=ЙpНs aut-affil-num=5 ORCID= en-aut-name=ManoMasayuki en-aut-sei=Mano en-aut-mei=Masayuki kn-aut-name=К╘ЦьР│ФV kn-aut-sei=К╘Ць kn-aut-mei=Р│ФV aut-affil-num=6 ORCID= en-aut-name=KomatubaraShoukiti en-aut-sei=Komatubara en-aut-mei=Shoukiti kn-aut-name=ПмП╝М┤Р│Лg kn-aut-sei=ПмП╝М┤ kn-aut-mei=Р│Лg aut-affil-num=7 ORCID= en-aut-name=KishimotoTakumi en-aut-sei=Kishimoto en-aut-mei=Takumi kn-aut-name=К▌Ц{СьЦд kn-aut-sei=К▌Ц{ kn-aut-mei=СьЦд aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=2 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=3 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=4 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=5 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=6 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=7 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@КOЙ╚ affil-num=8 en-affil= kn-affil=ЙкОRШJН╨ХaЙ@УрЙ╚ en-keyword=И▌ГOГНБ[ГАГXОюсЗ kn-keyword=И▌ГOГНБ[ГАГXОюсЗ en-keyword=И▌Кр kn-keyword=И▌Кр en-keyword=Gastric Glomus Tumor kn-keyword=Gastric Glomus Tumor END start-ver=1.4 cd-journal=joma no-vol=109 cd-vols= no-issue=3-6 article-no= start-page=41 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of near-ultraviolet radiation on choroidal circulation kn-title=ОЗКOР№В╠ЦмЧНЦМПzК┬В╔ЛyВ┌В╖ЙeЛ┐ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of near-ultraviolet radiation on choroidal blood flow were studied in aphakic rabbit eyes. After lens extraction, eyes were exposed to monochrometic nera-ultraviolet radiation with a wavelength of 365 nm and radiant exposure of 8.0 J/cm2. Choroidal blood flow was measured by the hydrogen clearance method 3, 7 and 14 days after exposure. Eyes were enucleated after the measurement of choroidal blood flow and examined histopathologically. Choroidal blood flow in the eyes wan significantly reduced 7 and 14 days after exposure compared with control eyes. Histopathologically, the photoreceptors showed markde destruction 3, 7 and 14 days after exposure, while the retinal pigment epithelium and choriocapillaris remained intact during this period. These results suggested that choroidal blood flow was reduced by decreased oxygen consumption in the outer retina as a result of the destruction of photoreceptors after exposure to near-ultraviolet radiation. en-copyright= kn-copyright= en-aut-name=IdeiNobuhiko en-aut-sei=Idei en-aut-mei=Nobuhiko kn-aut-name=ПoО╦РMХF kn-aut-sei=ПoО╦ kn-aut-mei=РMХF aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФКсЙ╚КwЛ│О║ en-keyword=ОЗКOР№ kn-keyword=ОЗКOР№ en-keyword=ЦмЧНЦМПzК┬ kn-keyword=ЦмЧНЦМПzК┬ en-keyword=РЕСfГNГКГAГЙГУГXЦ@ kn-keyword=РЕСfГNГКГAГЙГУГXЦ@ en-keyword=ОЛН╫ЦEКOР▀ kn-keyword=ОЛН╫ЦEКOР▀ END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=47 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on factors relating to oral malodor and preventive measures among the elderly kn-title=ЧvЙюМьНВЧюО╥В╔ВиВпВщМ√ПLВ╞В╗В╠К╓ШAЧvИЎЛyВ╤Ч\ЦhС╬НЇВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=One hundred ten elderly with disabilities in institutions or receiving home care were selected and informed. This study focused on oral malodor and discusses consent was obtained the relationship between oral malodor and the state of dental health and oral hygiene in the elderly with disabilities. ADL of the elderly with disabilities (rank J, A, B, C, settled by National Health Administration in Japan) were 8.2% at rank J, 28.2% at rank A, 42.7% at rank B and 20.9% at rank C, respectively. The incident rate of swallowing pneumonitis, fever and bedsores were low. Accordingly, physical and mental conditions were comparatively preferable. Tooth and periodontal conditions were comparablye to nationwide results. 1. The elderly in poor ADL had marked oral malodor compared with those in good health. 2. The elderly who required assistance to eat or had special dietary requirements had marked oral malodor. 3. The elderly who had normal oral functions and the ability to take care of their own oral hygiene had markedly less oral malodor. 4. The elderly who had poor oral hygiene exhibitings thick tongue coating and positive results in a Candida albicans culture test, had marked oral malodor. 5. Using, the multivariate statistical analysis of Hayashi methodsЗU, the coefficient of correlation between the state of oral malodor and 27 variables was obtained. 1) The study obtained trustworthy values that discriminate analysis 92.7% and correlation ratio is 0.53. 2) The variables related to severe oral malodor, extracted by the multivariate statistical analysis in descending order, were: "low level of ADL in gargling and denture brushing", "cigarette smoking", "speech disabilities", "unsatisfactory mastication", "need for special dietary care", "oral druyness", "gingivitis", "soft diet of side dish", "living in a special institution caring for the elderly", "thick tongue coating", and "a positive Candida albicans culture test", respectively. 3) The items related with comparatively comfortable or bearable oral malodor, extracted by the multivariate statistical analysis in descending order were : "satisfactory mastication", "home care", "healthy or poor eyesight", "difficulty in mastication", "being able to independently remove, dentures", "a negative Candida albicans culture test", "no oral dryness", "independents in selecting diet", "comfortable gingival condition", "being dependent on others for tooth-brushing" and "preferable tongue coating", respectively. 4) For the effective preventive countermeasures of oral malodor, ADL of oral health, caring circumstances and hygiene of gingiva/tongue should be focused on rather than dental hygiene itself. en-copyright= kn-copyright= en-aut-name=EgusaMasahiko en-aut-sei=Egusa en-aut-mei=Masahiko kn-aut-name=Н]СРР│ХF kn-aut-sei=Н]СР kn-aut-mei=Р│ХF aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЙqР╢КwНuН└ en-keyword=Elederly with disabilities kn-keyword=Elederly with disabilities en-keyword=Oral malodor kn-keyword=Oral malodor en-keyword=Preventive countermeasure kn-keyword=Preventive countermeasure en-keyword=Related factor kn-keyword=Related factor en-keyword=Multivariate statistical analysis kn-keyword=Multivariate statistical analysis END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=9-12 article-no= start-page=183 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An investigation into the factors of smoking cessation in male smokers kn-title=ТjРлЛiЙМО╥В╠Л╓ЙМО└НsЧvИЎВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract=This syudy was designed to clarify what factors influenced the ability to stop smoking in male smokers, from the viewpoint of life-style guidance and primary care. Of the people who attended abult health examinations between 1993 and 1998 in Okayama Ctiy, 987 male smokers were selected and categorized according to the number of cigarettes per day into three groups. The relation was analyzed statistically between the three groups and the life-style related factors : age, the degree of obesity, sleep, snacks, salt, exercise and alcohol. The results showed significant differences in age, the degree of obesity, sleep, salt, exercise. Second, the relation between threse three groups and the experience and duration of smoking cessation was analyzed. The results showed a significant differnce in the experience of smoking cessation, but no significant differnce in duration of smoking cessation. The conclusions are as follows : 1. Male smokers, who do not activedy try to improve of their life-style related factors, have fewer experiences of smoking cessation, 2. Male smokers who try to improve their life-style habits have a similar period od smoking cessation to those who do not. 3. Long term support for all male smokers to continue to be non-smoking is important. en-copyright= kn-copyright= en-aut-name=KawadaYuichi en-aut-sei=Kawada en-aut-mei=Yuichi kn-aut-name=РьУcЧ@Иъ kn-aut-sei=РьУc kn-aut-mei=Ч@Иъ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwИуКwХФЙqР╢ИуКwНuН└ en-keyword=ЛiЙМЦ{РФ kn-keyword=ЛiЙМЦ{РФ en-keyword=Р╢КИПKК╡ kn-keyword=Р╢КИПKК╡ en-keyword=МТНNИ╙Оп kn-keyword=МТНNИ╙Оп en-keyword=МТНNИ╙Ч~ kn-keyword=МТНNИ╙Ч~ en-keyword=Л╓ЙММoМ▒ kn-keyword=Л╓ЙММoМ▒ en-keyword=Н─ЛiЙМ kn-keyword=Н─ЛiЙМ END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=3 article-no= start-page=299 end-page=300 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ГvГКГIГУХa en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФНNУё kn-aut-sei=ИвХФ kn-aut-mei=НNУё aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКwСхКwЙ@ИуОХКwСННЗМдЛЖЙ╚Р_МoХaС╘УрЙ╚Кw END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=27 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of Core-cities Growth on the Regional Economic Development in China en-subtitle= kn-subtitle= en-abstract= kn-abstract=China has achieved a remarkable economic growth in the past two decades. However, the rapid economic development has led to regional disparities between the advanced coastal regions and the other regions. Regional development planning in China has sought to achieve the redress of regional disparities as well as a high economic growth. This paper aims to examine the role of core cities in the development of Chinese regional economy and their impact on regional differentials. Following a brief review of regional development planning in China, the paper examines the role of core cities on the regional development and the trends in regional disparities using data for seven coastal provinces (Guangdong, Fujian, Zhejiang, Jiangsu, Shandong, Hebei and Liaoning) and three municipalities (Beijing, Tianjin and Shanghai) in the period 1989-1997. It shows that while the coastal regions achieved a high economic growth, the extent of regional disparities and the contributions of core cities to the reduction of economic differentials varied among provinces. The paper concludes by proposing future issues on regional development planning in China. en-copyright= kn-copyright= en-aut-name=ZouDagang en-aut-sei=Zou en-aut-mei=Dagang kn-aut-name=ZouDagang kn-aut-sei=Zou kn-aut-mei=Dagang aut-affil-num=1 ORCID= en-aut-name=AbeHirofumi en-aut-sei=Abe en-aut-mei=Hirofumi kn-aut-name=ИвХФНGОj kn-aut-sei=ИвХФ kn-aut-mei=НGОj aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw affil-num=2 en-affil= kn-affil=ЙкОRСхКw en-keyword=regional disparities kn-keyword=regional disparities en-keyword=core cities kn-keyword=core cities en-keyword=per capita GDP kn-keyword=per capita GDP en-keyword=lavor productivity kn-keyword=lavor productivity en-keyword=per capita employment kn-keyword=per capita employment END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=618 article-no= start-page=200 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Heat Storage Characteristics of an Inclined Rectangular Heat Storage Vessel Packed with Plate Type of Shape-Stabilized Phase Change Material kn-title=МXО╬ФzТuВ╡В╜Х╜Ф┬ПєМ`ПєИ└ТшЙ╗РЎФMТ~ФMН▐П[УUЛщМ`Т~ФMСЕВ╠Т~ФMУ┴Рл en-subtitle= kn-subtitle= en-abstract=ИъФ╩В╔БAРЎФMТ~ФMСЕВ╠Т~ФMЙ▀ТЎВ┼В═БAФMФ}С╠ЧмСмВЁЛ╔Ч═ПмВ│ВнВ╖ВщВ▒В╞В╔ВцВшБAИ│Ч═С╣О╕В╠МyМ╕ВтФMФ}С╠В╠ОЭВ┬ФMГGГlГЛГMБ[В╠ЧLМ°ЧШЧpВЁР}ВщООВ▌ВкВ╚В│ВъВ─ВиВшБAВ│ВчВ╔РЎФMВ╠Х·ФMЙ▀ТЎВ┼В═БAПмВ│В╚ФMФ}С╠ЧмСмВ╔ВцВшБAИъТшВ╠НВЙ╖РЕПАВ┼В╠ФMТКПoВкЙ┬Ф\В╞В╚ВщБBЧсВжВ╬БAъОУбВчВ╠МдЛЖВ╔ВиВвВ─В═БAЛЕГJГvГZГЛВЁП[УUВ╡В╜Й~УЫМ`Т~ФMСЕУрФMФ}С╠В╠ЧмСмВ═10mm/sИ╚Й║В╠ТсЧмСмЧ╠ИцВ┼ВаВщБBВ▄В╜БAИвХФВчВ╠ХёНРВ╡В╜Й~УЫПєТ~ФMН▐П[УUТ~ФMСЕУрВ╠ФMФ}С╠ЧмСмВ═Цё0.5mm/sВ╞Л╔В▀В─ПмВ│ВвВрВ╠В┼ВаВщБBВ▒В╠ВцВдВ╔БAФMФ}С╠В╠ЛнРзС╬ЧмВ╔ВцВщЧмСмВкПмВ│ВвПъНЗВ╔В═БAПєЛ╡В╔ВцВ┴В─Т~ФMСЕУрВ╠ФMФ}С╠ЧмШHВ╔ФнР╢В╡В╜ОйСRС╬ЧмВкВ╗В╠ФMУ`ТBУ┴РлВЁСхВлВнН╢ЙEВ╖ВщВ▒В╞В╔В╚ВшБAЛнРзБ|ОйСRЛдС╢С╬ЧмВ╠МЯУвВкХKЧvВ╞В╚ВщБBЧмШHУрВ╠ЛнРзБ|ОйСRЛдС╢С╬ЧмВ╔ЛNИЎВ╖ВщУ`ФMМ╗П█В═ЧмШHМ`ПєБAПdЧ═Х√М№В╔С╬В╖ВщЛнРзС╬ЧмВ╠ЧмВъХ√М№БAЧмШHВ╠Й┴ФMВ▄В╜В═ЧтЛpПЁМПВ╚В╟ПФИЎОqВ╔ВцВ┴В─ХбОGВ╚ЧlСКВЁТцВ╖ВщБBЛнРзБ|ОйСRЛдС╢С╬ЧмУ`ФMМ╗П█В═БAУdОqЛ@КэВ╠ПЬФMВтСхЧmПBФMКэВ╚В╟В╔ВиВвВ─РФС╜ВнМйВчВъВщБBВ▒В╠ПъНЗВ╠У`ФMМ╗П█В╠ЙЁР═УIИ╡ВвВ═ЛщМ`ЧмШHХ╟В╠ФMЛлКEПЁМПВ╞В╡В─УЩЙ╖В╗В╡В─УЩФMЧмСйВ╠М┼ТшПЁМПВ╠ПъНЗВкСхФ╝В┼БAВ╗В╠Х╟Ц╩Й╖УxВкВ╗В╠УрХФВ╔ЧLВщСКХ╧Й╗ХиО┐В╠РЎФMЛzО√ВтХ·ПoВ╔ВцВшХ╧Й╗В╖ВщВцВдВ╚ПъНЗВ═В┘В╞ВёВ╟ОцВшПуВ░ВчВъВ─ВвВ╚ВвМ╗ПєВ╔ВаВщБBТШО╥ВчВ═РВТ╝ФzТuВ╡В╜ЛщМ`РЎФMТ~ФMСЕУрВ╠Т~ФMЛyВ╤Х·ФMУ┴РлВ╔СхВлВнЙeЛ┐ВЁЛyВ┌В╖В▒В╞ВЁЦ╛ВчВйВ╔В╡В─ВвВщБBЧсВжВ╬БAФMФ}С╠У№М√ЧмСмВкV=0.2mm/sВ╠Х·ФMЙ▀ТЎВ╔ВиВвВ─В═БAЙ║М№ВлЧмВъБiЛнРзС╬ЧмХ√М№В═ПdЧ═Х√М№В╞УпВ╢ПъНЗБjВ╔ВиВвВ─В═БAПуМ№ВлЧмВъБiЛнРзС╬ЧмХ√М№В═ПdЧ═Х√М№В╞ЛtВ╠ПъНЗБjВ╔ФфКrВ╡В─БAЧмШHУрВ╔ФнР╢В╡В╜ОйСRС╬ЧмВкФMУ`ТBВЁСjКQВ╡БAВ╗В╠Х·ФMКоЧ╣ОЮК╘ВЁСхХЭВ╔СЭСхВ╖ВщМЛЙ╩В╞В╚ВщБBЦ{МдЛЖВ═БAХ╜Ф┬ПєМ`ПєИ└ТшЙ╗ПИЧЭГpГЙГtГBГУРЎФMТ~ФMН▐ВкП[УUВ│ВъВ╜ЛщМ`Т~ФMСЕВЁМдЛЖС╬П█В╞В╡БAУёОЯМ│ФёТшПэРФТlЙЁР═В╔ВцВшБAЛщМ`Т~ФMСЕВЁМXО╬В╖ВщВ▒В╞В╔ВцВшОйСRС╬ЧмВЁЧ}РзВ╡В╜ПъНЗВ╔ВиВпВщЛнРзБ|ОйСRЛдС╢С╬ЧмФMУ`ТBВ╠Т~ФMУ┴РлВ╔ЛyВ┌В╖М°Й╩ВЁМЯУвВ╖ВщВрВ╠В┼ВаВщБBВ│ВчВ╔БAФMФ}С╠Т~ФMСЕУ№М√ЧмСмБAУ№М√Й╖УxЛyВ╤ФMФ}С╠ЧмШHХЭВ╠Т~ФMУ┴РлВ╔ЛyВ┌В╖ЙeЛ┐ВрХ╣В╣В─МЯУвВЁНsВ┴В─ВаВщБB kn-abstract=The present study deals with the heat storage characteristics of the inclined rectangular vessel packed with spape-stabilized paraffin plates as a latent heat storage material by numerical analysis. It was found that the heat storage characteristics were remarkedly affected by the inclination angle of the rectangular vessel and the heat transfer medium flow direction, due to the presence of natural convection in the fluid flow channel between the paraffin plates. Numerical results revealed flow patterns, temperature profiles and heat storage characteristics for various inclination angles, inlet velocities and temperatures of the heat transfer medium fluid, and widths of the fluid flow channel. en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name=ИюЧtЙpТj kn-aut-sei=ИюЧt kn-aut-mei=ЙpТj aut-affil-num=1 ORCID= en-aut-name=PingTu en-aut-sei=Ping en-aut-mei=Tu kn-aut-name=PingTu kn-aut-sei=Ping kn-aut-mei=Tu aut-affil-num=2 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name=ЦxХФЦ╛ХF kn-aut-sei=ЦxХФ kn-aut-mei=Ц╛ХF aut-affil-num=3 ORCID= en-aut-name=OzakiKoichi en-aut-sei=Ozaki en-aut-mei=Koichi kn-aut-name=ФЎНшМЎИъ kn-aut-sei=ФЎНш kn-aut-mei=МЎИъ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw affil-num=2 en-affil= kn-affil=ЙкОRСхКw affil-num=3 en-affil= kn-affil=ЙкОRСхКw affil-num=4 en-affil= kn-affil=ЙкОRСхКw en-keyword=Shape-Stabilized Phase Change Material kn-keyword=Shape-Stabilized Phase Change Material en-keyword=Heat Storage Process kn-keyword=Heat Storage Process en-keyword=Numerical Analysis kn-keyword=Numerical Analysis en-keyword=Transient Heat Transfer kn-keyword=Transient Heat Transfer en-keyword=Natural-Forced Convections kn-keyword=Natural-Forced Convections END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1 article-no= start-page=45 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Induction of Atherosclerosis in Aorta and Coronary Artery of Chicken by Orally Administered Cholesterol kn-title=ГRГМГXГeГНБ[ГЛХЙЙ╫В╔ВцВ┴В─ФнП╟В╡В╜ГjГПГgГКЛ╣ХФСхУоЦмВ╞КеПєУоЦмВ╔ВиВпВщУоЦмНdЙ╗П╟ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hypercholesterolemia and hyperlipidemia have been important in human health as factors that induce atherosclerotic lesions in brain and heart blood vessel. Various experimental studies have been done to prevent and treat atherosclerotic lesions in animals. In the present study, we assessed the suitability of chickens as experimental animal for atherosclerosis. Newly hatched chicks were fed on 1.0%-or 0.1%-cholesterol(CHO) containing feed. After 3 and 6 months, total cholesterol levels in the sera and histological changes in the aorta and coronary artery of chicks fed on 1.0%-CHO-containing feed for 3 and 6 months, intimal thickening and marked accumulation of foam cells were observed. Endothelial cells had disappeared in the aorta of these chicks. A slight accumulation of foam cells was observed in the aortic intima of chicks fed on 0.1%-CHO-containing feed. In the coronary artery, a remarkable thickening of intima with accumulation of foam cells and a marked stenosis of coronary space were observed in chicks fed on 1.0%-CHO-containing feed. The results of present study indicate that the chicken can be a useful experimental animal in the study of hypercholesterolemia, hyperlipidemia and atherosclerosis. en-copyright= kn-copyright= en-aut-name=KondoYasuhiro en-aut-sei=Kondo en-aut-mei=Yasuhiro kn-aut-name=Л▀УбНNФО kn-aut-sei=Л▀Уб kn-aut-mei=НNФО aut-affil-num=1 ORCID= en-aut-name=HonjoSachika en-aut-sei=Honjo en-aut-mei=Sachika kn-aut-name=Ц{ЮКНKНБ kn-aut-sei=Ц{ЮК kn-aut-mei=НKНБ aut-affil-num=2 ORCID= en-aut-name=OhtsukiKazumasa en-aut-sei=Ohtsuki en-aut-mei=Kazumasa kn-aut-name=СхМООїЙh kn-aut-sei=СхМО kn-aut-mei=ОїЙh aut-affil-num=3 ORCID= en-aut-name=AbeAsaki en-aut-sei=Abe en-aut-mei=Asaki kn-aut-name=ИвХФРєОў kn-aut-sei=ИвХФ kn-aut-mei=РєОў aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw affil-num=2 en-affil= kn-affil=ЙкОRСхКw affil-num=3 en-affil= kn-affil=ЙкОRСхКw affil-num=4 en-affil= kn-affil=ЙкОRСхКw en-keyword=experimental atherosclerosis kn-keyword=experimental atherosclerosis en-keyword=cholrsterol kn-keyword=cholrsterol en-keyword=chicks kn-keyword=chicks END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=1 article-no= start-page=55 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ГjГПГgГКуєВ╠ГtГ@ГuГКГVГEГXФXВ╔ВиВпВщВaГКГУГpЛЕВ╠ФнТBВ╔С╬В╖Вщ sIgM ЧUУ▒ИЎОqВ╠ЦЁКД kn-title=Role of the Surface IgM-Inducing Factor in Development of B Lymphocytes in Chicken Embryonic Bursa of Fabricius en-subtitle= kn-subtitle= en-abstract=ГtГ@ГuГКГVГEГXФXВ═ВaГКГУГpЛЕХкЙ╗В╞СЭРBВ╠В╜В▀В╠ТЖРХГКГУГpСgРDВ╞В╡В─Т╣Ч▐В╠Ц╞ЙuЛ@Ф\В╠ФнТBВ╔ВиВвВ─ПdЧvВ╚ЦЁКДВЁЙЙВ╢В─ВвВщБDФ|Ч{ГtГ@ГuГКГVГEГXФXПуФчН╫ЦEВ═уєВ╠ГtГ@ГuГКГVГEГXФXГКГУГpЛЕВ╔ЦМВ╠ IgM ХкОqБisIgMБjВ╠Фн М╗ВЁЧUУ▒В╖ВщИЎОqВЁОYР╢В╖ВщВ▒В╞ВкХёНРВ│ВъВ─ВвВщБDГtГ@ГuГКГVГEГXФXГКГУГpЛЕВ╠ sIgM ФнМ╗ЧUУ▒ИЎОqВ╔С╬В╖ВщК┤ОєРлВ═ГtГ@ГuГКГVГEГXФXВ╔ВиВпВщХкЙ╗В╠ОЮК·В╔ВиВвВ─Х╧УоВ╖ВщЙ┬Ф\РлВкНlВжВчВъВщБDГjГПГgГКВ╠уєВ┼В═БCГКГУГpЛЕМnВ╠СOЛьН╫ЦEВ═уєФнТBВ╠ВVУ·Ц┌ВйВч14У·Ц┌В╠К╘В╔ВиВвВ─В╠В▌ГtГ@ГuГКГVГEГXФXВ╔РiУ№БEТшТЕВ╖ВщВ▒В╞ВкТmВчВъВ─ВвВщБDВ╗В▒В┼Ц{МдЛЖВ┼В═БCГКГУГpЛЕМnСOЛьН╫ЦEВкГtГ@ГuГКГVГEГXФXВ╔ТшТЕВ╖ВщВ▒В╠ОЮК·Бi10У·уєВйВч13У·уєБjВ╔ВиВпВщГtГ@ГuГКГVГEГXФXГКГУГpЛЕВ╠ sIgM ФнМ╗В╠Х╧УоВЁТ▓В╫ВщВ╞В╞ВрВ╔БCВ▒ВъВчВ╠Н╫ЦEВ╔ВиВпВщ sIgM ФнМ╗ЧUУ▒ИЎОqВ╔С╬В╖ВщК┤ОєРлВ╠Х╧УоВ╔В┬ВвВ─СкТшВ╡В╜БDsIgM ЧzРлН╫ЦEВ╠КДНЗВ═11У·уєВ┼ЧLИ╙В╔ПуП╕В╡В╜БDsIgM ФнМ╗ЧUУ▒ИЎОqВ╔С╬В╖ВщФ╜ЙЮРлВ═В▒В╠ОЮК·В╠уєФнТBВ╔Ф║В┴В─Х╧УоВ╡БC11У·уєВ┼НВВвМXМ№ВЁОжВ╡В╜БDВ▒ВъВчВ╠МЛЙ╩ВйВчБC11У·уєЧюВ═ГjГПГgГКуєВ╠ГtГ@ГuГКГVГEГXФXВ╔ВиВпВщВaГКГУГpЛЕВ╠ФнТBВ╔К╓В╡В─ПdЧvВ╚ОЮК·В┼ВаВщВ▒В╞ВкОжН┤В│ВъВ╜БD kn-abstract=Б@The bursa of Fabricius plays essential roles in the establishment of immune functions of avian species as a primary site for differentiation and proliferation of B lymphocytes. The bursa of chick embryos is colonized by lymphoid cell precursors only between the days 7th of embryogenesis (E7) and E14. Susceptibility to the sIgM-inducing factor may fluctuate in bursal lymphoid cells during the lymphoid precursor cell-receptive period. In the present study, the dynamic changes in the sIgM-positive ratio and responsiveness to sIgM-inducing factor were examined in lymphoid cells sampled from the bursa during the B precursor cell-receptive period (E10 to E13) and findings suggest that responsiveness to sIgM-inducing factor varies with the development of the chick embryos. E11 is suggested to be a critical stage of B-lymphocytegenesis in the bursa of chick embryos. en-copyright= kn-copyright= en-aut-name=HanSong en-aut-sei=Han en-aut-mei=Song kn-aut-name=К╪П╝ kn-aut-sei=К╪ kn-aut-mei=П╝ aut-affil-num=1 ORCID= en-aut-name=AbeAsaki en-aut-sei=Abe en-aut-mei=Asaki kn-aut-name=ИвХФРєОў kn-aut-sei=ИвХФ kn-aut-mei=РєОў aut-affil-num=2 ORCID= en-aut-name=NaraharaKiyoaki en-aut-sei=Narahara en-aut-mei=Kiyoaki kn-aut-name=УшМ┤Р┤М░ kn-aut-sei=УшМ┤ kn-aut-mei=Р┤М░ aut-affil-num=3 ORCID= en-aut-name=KondoYasuhiro en-aut-sei=Kondo en-aut-mei=Yasuhiro kn-aut-name=Л▀УбНNФО kn-aut-sei=Л▀Уб kn-aut-mei=НNФО aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw affil-num=2 en-affil= kn-affil=ЙкОRСхКw affil-num=3 en-affil= kn-affil=ЙкОRСхКw affil-num=4 en-affil= kn-affil=ЙкОRСхКw en-keyword=bursa of Fabricius kn-keyword=bursa of Fabricius en-keyword=B lymphocytegenesis kn-keyword=B lymphocytegenesis en-keyword=sIgM-inducing factor kn-keyword=sIgM-inducing factor END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Т┤ГCГIГУУ▒УdС╠В╔ВиВпВщИ┘ПэУdЛCУ`У▒УxВ╔К╓В╖ВщМдЛЖ -К╔ШaГВБ[ГhЧЭШ_В╔ВцВщЙЁР═- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЧШСе kn-aut-sei=ИвХФ kn-aut-mei=ЧШСе aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ОЭС▒УIИ│Ч═В╔ВцВщЛ`ОХП░Й║СgРDВ╠ХaЧЭСgРDКwУIХ╧Й╗В╔С╬В╖ВщУЬФAХaВ╠ЙeЛ┐В╔К╓В╖ВщО└М▒УIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФПrХF kn-aut-sei=ИвХФ kn-aut-mei=ПrХF aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=РlНHЙhЧ{ОйЧеЪMУ√В╔УKВ╡В╜Х▓У√П`В╠Т`ФТСgРмВ╔К╓В╖ВщМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeTakeshi en-aut-sei=Abe en-aut-mei=Takeshi kn-aut-name=ИвХФЦ╥ kn-aut-sei=ИвХФ kn-aut-mei=Ц╥ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw en-keyword=РlНHЙhЧ{ОйЧеЪMУ√ kn-keyword=РlНHЙhЧ{ОйЧеЪMУ√ en-keyword=Х▓У√П` kn-keyword=Х▓У√П` en-keyword=Т`ФТСgРм kn-keyword=Т`ФТСgРм END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=фBВ╠ФфКrСgРDКwУIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЦ╬Рl kn-aut-sei=ИвХФ kn-aut-mei=Ц╬Рl aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Г}ГEГXВ╔ВиВпВщО└М▒УIУ`РїРлФ^сoР]В╠НьРм kn-title=Production of experimental staphylococcal impetigo in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeYoshiko en-aut-sei=Abe en-aut-mei=Yoshiko kn-aut-name=ИвХФФ\Оq kn-aut-sei=ИвХФ kn-aut-mei=Ф\Оq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw en-keyword=experimental staphylococcal impetigo kn-keyword=experimental staphylococcal impetigo END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ГAГfГmГEГCГЛГX12М^ФнКрРлВ╔С╬В╖ВщС┘ОЩЦ╞ЙuВ╠М°Й╩ kn-title=Effect of immunization with fetal cells on adenovirus-12 oncogenesis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФР\ОЯ kn-aut-sei=ИвХФ kn-aut-mei=Р\ОЯ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Г}ГEГXЗ\М^ГRГЙБ[ГQГУГ┐1Н╜В╠СSИъОЯН\СвЛyВ╤ОИЙшМ`РмВ╔ВиВпВщВ╗В╠ФнМ╗В╔В┬ВвВ─ kn-title=The complete primary structure of the long form of mouse Г┐ 1 (З\) collagen chain and its expression during limb development en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name=ИвХФРMК░ kn-aut-sei=ИвХФ kn-aut-mei=РMК░ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw en-keyword=mouse Г┐ 1 (З\) collagen kn-keyword=mouse Г┐ 1 (З\) collagen en-keyword=limb development kn-keyword=limb development END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19720630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ГlГRВ╠ОЛП░МуХаСдКjВ╠ОЛП░УрМЛНЗВ╔К╓В╖ВщО└М▒ЙЁЦUКwУIМдЛЖ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbeKumashige en-aut-sei=Abe en-aut-mei=Kumashige kn-aut-name=ИвХФМFПd kn-aut-sei=ИвХФ kn-aut-mei=МFПd aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw en-keyword=ОЛП░МуХаСдКj kn-keyword=ОЛП░МуХаСдКj en-keyword=ОЛП░УрМЛНЗ kn-keyword=ОЛП░УрМЛНЗ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Р│ПэЛyВ╤ГAГ~ГmГIГLГVР|О_УКЧ^ГЙГbГgВ╠СgРDТКПoЙtТЖЛyВ╤ФAТЖГ└-ГAГЙГjГУ,Г└-ГAГ~ГmГCГ\ЧПО_,Г┴ГAГ~ГmЧПО_В╠НВСмЙtС╠ГNГНГ}ГgГOГЙГtиБ[В╔ВцВщТшЧ╩ kn-title=High-performance liquid chromatographic determination of Г└-alanine,Г└-aminoisobutyric acid and Г┴-aminobutyric acid in tissue extracts and urine of normal and (aminooxy) acetate-treated rats en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ИвХФЛзОj kn-aut-sei=ИвХФ kn-aut-mei=ЛзОj aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ЙкОRСхКw en-keyword=Г└-alanine kn-keyword=Г└-alanine en-keyword=Г└-aminoisobutyric acid kn-keyword=Г└-aminoisobutyric acid en-keyword=Г┴-aminobutyric acid kn-keyword=Г┴-aminobutyric acid END