検索結果 - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

A Phase I Trial of 100mg/m2 Docetaxel in Patients with Advanced or Recurrent Breast Cancer

JaLCDOI	10.18926/AMO/54607
FullText URL	70_5_425.pdf
Author	Tamura, Tomoki\| Hirata, Taizo\| Tabata, Masahiro\| Hinotsu, Shiro\| Hamada, Akinobu\| Motoki, Takayuki\| Iwamoto, Takayuki\| Mizoo, Taeko\| Nogami, Tomohiro\| Shien, Tadahiko\| Taira, Naruto\| Matsuoka, Junji\| Doihara, Hiroyoshi\|
Abstract	Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer.
Keywords	breast cancer phase I trial docetaxel
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-10
Volume	volume70
Issue	issue5
Publisher	Okayama University Medical School
Start Page	425
End Page	427
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27777441
Web of Science KeyUT	000388098700018

The induction of antigen-specific CTL by in situ Ad-REIC gene therapy

FullText URL	K0005392_abstract_review.pdf K0005392_fulltext.pdf
Author	Ariyoshi, Yuichi\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5392号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells

FullText URL	K0005391_abstract_review.pdf K0005391_fulltext.pdf
Author	Toma, Kishio\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5391号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases

FullText URL	K0005390_abstract_review.pdf K0005390_fulltext.pdf
Author	Isozaki, Hideko\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5390号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

Soluble form of the receptor for advanced glycation end-products attenuates inflammatory pathogenesis in a rat model of lipopolysaccharide-induced lung injury

FullText URL	K0005389_abstract_review.pdf K0005389_fulltext.pdf
Author	Izushi, Yasuhisa\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5389号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy

FullText URL	K0005388_abstract_review.pdf K0005388_fulltext.pdf
Author	Muraoka, Michiko\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5388号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

Effect of Vandetanib on Lung Tumorigenesis in Transgenic Mice Carrying an Activating Egfr Gene Mutation

FullText URL	K0005387_abstract_review.pdf K0005387_fulltext.pdf
Author	Osawa, Masahiro\|
Published Date	2016-06-30
Content Type	Thesis or Dissertation
Grant Number	甲第5387号
Granted Date	2016-06-30
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
language	English

第115回岡山医学会総会

Title Alternative	The 114th General Assembly of the Okayama Medical Association
FullText URL	128_157.pdf
Author	岡山医学会\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	157
End Page	163
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/ 10.4044/joma.128.157
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.157
NAID	130005262635

第87回岡山胸部疾患懇話会

Title Alternative	The 87th Okayama Chest Disease Conference
FullText URL	128_155.pdf
Author	岡山医学会\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	155
End Page	156
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.155
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.155
NAID	130005262647

第31回日本脳神経血管内治療学会学術総会（JSNET2015岡山）を終えて

Title Alternative	Review of the 31st Annual Meeting of the Japanese Society for NeuroEndovascular Therapy (JSNET 2015 Okayama)
FullText URL	128_151.pdf
Author	Sugiu, Kenji\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	151
End Page	153
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.151
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.151
NAID	130005262641

特定医療法人竹下会竹下病院

FullText URL	128_149.pdf
Author	竹下篤範\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	149
End Page	150
ISSN	0030-1558
Official Url	http://www.okayama-u.ac.jp/user/oma/\|
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher

AMED（エーメド）

Title Alternative	Japan Agency for Medical Research and Development
FullText URL	128_147.pdf
Author	Tomoyasu, Yumiko\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	147
End Page	148
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.147
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.147
NAID	130005262639

薬物相互作用（36―肺癌領域における経口分子標的治療薬）

Title Alternative	Drug interaction (36. Combination with oral molecular target drugs in lung cancer)
FullText URL	128_141.pdf
Author	Higashionna, Tsukasa\| Esumi, Satoru\| Kitamura, Yoshihisa\| Sendo, Toshiaki\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	141
End Page	146
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.141
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.141
NAID	130005262644

平成28年熊本地震に対する岡山大学病院DMAT活動報告

Title Alternative	Okayama University Hospital DMAT activity report for the 2016 Kumamoto Earthquake
FullText URL	128_133.pdf
Author	Terado, Michihisa\| Yamanouchi, Hideo\| Nakura, Hironori\| Nakao, Atsunori\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	133
End Page	139
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.133
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.133
NAID	130005262643

Q9 ・Q10・Q11

Title Alternative	Q9 ・Q10・Q11
FullText URL	128_129.pdf
Author	岡山医学会\|
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	129
End Page	132
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.129
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.129
NAID	130005262660

新教育技法「チーム基盤型学習（TBL）」の有用性

Title Alternative	The effectiveness of team-based learning (TBL) as a new teaching approach
FullText URL	128_125.pdf
Author	Suno, Manabu\|
Keywords	アクティブラーニング（active learning）チーム基盤型学習（team-based learning）問題基盤型学習（problem-based learning）
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	125
End Page	128
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.125
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.125
NAID	130005262530

中央西日本臨床研究コンソーシアム

JaLCDOI	10.18926/54461
Title Alternative	Mid-West Japan Clinical Study Consortium
FullText URL	128_121.pdf
Author	Shikata, Kenichi\|
Keywords	中央西日本臨床研究コンソーシアム岡山大学病院 ARO 臨床研究治験
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	121
End Page	123
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.121
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.121
NAID	130005262529

腸骨広範囲切除術後に発生した腹壁瘢痕ヘルニアに対しメッシュ修復術を行った一例

Title Alternative	Incisional hernia repair after wide excision of the iliac bone
FullText URL	128_117.pdf
Author	Tsukuda, Kazunori\| Asano, Hiroaki\| Mandai, Yasuhiro\| Fujiwara, Toshiyoshi\|
Abstract	The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair.
Keywords	腹壁瘢痕ヘルニア（incisional hernia）腸骨軟骨肉腫（chondrosarcoma of the iliac bone）腸骨広範囲切除術（wide excision of the iliac bone）プロリーンメッシュ（prolene mesh）
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	117
End Page	120
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.117
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.117
NAID	130005262528

拡大内視鏡検査にて形態変化を観察しえた十二指腸濾胞性リンパ腫の1例

Title Alternative	Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma
FullText URL	128_111.pdf
Author	Iwamuro, Masaya\| Takata, Katsuyoshi\| Kawano, Seiji\| Kawahara, Yoshiro\| Yoshino, Tadashi\| Okada, Hiroyuki\|
Abstract	A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation.
Keywords	消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma）悪性リンパ腫（malignant lymphoma）拡大内視鏡検査（magnifying endoscopy）
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	111
End Page	116
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.111
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.111
NAID	130005262531

アディポカイン「バスピン」の同定とメタボリックシンドロームにおける意義

Title Alternative	Identification of the adipokine ‘vaspin’ and its significance in metabolic syndrome
FullText URL	128_103.pdf
Author	Wada, Jun\|
Keywords	metabolic syndrome adipokine atherosclerosis endothelial cells apoptosis
Publication Title	Journal of Okayama Medical Association
Published Date	2016-08-01
Volume	volume128
Issue	issue2
Start Page	103
End Page	109
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.128.103
language	Japanese
Copyright Holders	Copyright (c) 2016 岡山医学会
File Version	publisher
DOI	10.4044/joma.128.103
NAID	130005262534

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