脳の窒素代謝 第10編 トランキライザーの大黒鼠脳髄アンモニア並びにアミノ酸に及ぼす影響について

In the case of meprobamate application and reserpine injection as tranquilizing treatment, the content of ammonia in the brain was determined by Conwy's micro-diffusion method while that of amino acid by paper chromatography; and the following results were obtained: 1) After meprobamate application per os (1g. per dose), the contents of ammonia. glutamic acid and γ-amino-butylic acid decreased, while those of glutamine and aspartic acid increased. 2) In the group given meprobamate for successive days (350 mg-400 mg/kg), the content of ammonia increased, whereas those of glutamic acid, glutamine, γ-amino-butylic acid and aspartic acid less markedly. 3) In the case of reserpine injection (0.4 mg./kg), ammonia decreased markedly and glutamic acid and γ-amino-butylic acid less markedly. 4) In the group receiving reserpine injections for successive days (0.025 mg/kg/day), the content of ammonia showed a decrease, while that of aspartic acid an increase.