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FullText URL mjou_008_117_123.pdf
Author Tominaga, Hisao|
Published Date 1958-12
Publication Title Mathematical Journal of Okayama University
Volume volume8
Issue issue2
Publisher Department of Mathematics, Faculty of Science, Okayama University
Start Page 117
End Page 123
ISSN 0030-1566
NCID AA00723502
Content Type Journal Article
language English
Copyright Holders Copyright©1958 by the Editorial Board of Mathematical Journal of Okayama University
FullText URL mjou_008_107_116.pdf
Author Ōtsuki, Tominosuke|
Published Date 1958-12
Publication Title Mathematical Journal of Okayama University
Volume volume8
Issue issue2
Publisher Department of Mathematics, Faculty of Science, Okayama University
Start Page 107
End Page 116
ISSN 0030-1566
NCID AA00723502
Content Type Journal Article
language English
Copyright Holders Copyright©1958 by the Editorial Board of Mathematical Journal of Okayama University
Title Alternative A Note on Creditor’s Duty to Surety: Focused on German Law and Draft Common Frame of Reference
FullText URL olj_70_2_210_187.pdf
Author Tsuji, Hiroaki|
Publication Title Okayama Law Journal
Published Date 2020-12-18
Volume volume70
Issue issue2
Start Page 210
End Page 187
ISSN 0386-3050
language Japanese
File Version publisher
NAID 120006948948
JaLCDOI 10.18926/AMO/61217
FullText URL 74_6_557.pdf
Author Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki|
Abstract A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
Keywords 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 557
End Page 562
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361878
Web of Science KeyUT 000601203600014
NAID 120006948944
JaLCDOI 10.18926/AMO/61216
FullText URL 74_6_551.pdf
Author Tanaka, Masato| Fujiwara, Yoshihiro| Uotani, Koji| Kadiri, Venkatesh| Yamauchi, Taro|
Abstract A minimally invasive posterolateral approach designed to avoid the lateral misplacement of midcervical pedicle screws was reported, but there is no technical report that describes this technique without C-arm fluoroscopy. We report the results of a 2.5 years follow-up of a 62-year-old female patient with C4 metastatic breast cancer. The patient suffered from severe neck pain and impending quadriplegia for 2 months after radiation therapy. We performed C-arm-free minimally invasive cervical pedicle screw fixation (MICEPS). The patient was suc-cessfully treated with surgery, and her neck pain was well controlled. She had neither neurological deficits nor neck pain at the final (2.5-year) follow-up. C-arm-free MICEPS is a useful technique; in addition, the sur-geons and staff have no risk of radiation exposure, there is a reduced need for postoperative imaging, and a decreased revision rate can be expected with C-arm-free MICEPS.
Keywords cervical spine navigation surgery minimally invasive surgery cervical pedicle screw C-arm free
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 551
End Page 556
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361877
Web of Science KeyUT 000601203600013
NAID 120006948943
JaLCDOI 10.18926/AMO/61215
FullText URL 74_6_545.pdf
Author Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu|
Abstract Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
Keywords methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 545
End Page 550
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361876
Web of Science KeyUT 000601203600012
NAID 120006948942
JaLCDOI 10.18926/AMO/61209
FullText URL 74_6_495.pdf
Author Calliope, Simba Akintije| Yorifuji, Takashi| Wada, Takayuki| Mukakarake, Marie Goret| Mutesa, Leon| Yamamoto, Taro|
Abstract In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings.
Keywords antenatal care epidemiology low birth weight preterm birth rural
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 495
End Page 503
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361869
Web of Science KeyUT 000601203600005
NAID 120006948958
JaLCDOI 10.18926/AMO/61207
FullText URL 74_6_483.pdf
Author Miyagi, Yasunari| Miyake, Takahito|
Abstract We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, −3.8 ± 8.6, and −0.32 ± 6.3 (g) at −2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were −1.5 ± 9.4, −2.5 ± 7.3, and −1.1 ± 6.7 (g) for −2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights.
Keywords deep learning artificial intelligence fetal weight neural network ultrasound biometry
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 483
End Page 493
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361868
Web of Science KeyUT 000601203600004
NAID 120006948957
JaLCDOI 10.18926/AMO/61206
FullText URL 74_6_475.pdf
Author Harada, Ryo| Sato, Ryosuke| Tsutsui, Tomoaki| Hattori, Nao| Inoue, Masafumi| Kobashi, Haruhiko|
Abstract The insertion of a self-expandable metal stent (SEMS) for nonpancreatic cancer is a factor predicting the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). We evaluated the efficacy of endo-scopic pancreatic stenting (EPS) to prevent PEP after SEMS insertion in patients with malignant distal biliary stricture and without main pancreatic duct (MPD) obstruction. We performed a single-center, retrospective, historically controlled investigation to assess the outcomes of 33 consecutive patients who underwent SEMS insertion. From March 2013 to June 2015, 13 patients did not undergo EPS (Non-EPS group). The other 20 patients underwent EPS (EPS group) between July 2015 and August 2018. The background data demonstrated no significant differences. Except for one patient in the Non-EPS group, all patients underwent biliary sphinc-terotomy. The EPS group’s PEP incidence was significantly lower (n = 1, 5%) than that of the Non-EPS group (n = 4, 31%) (p = 0.04). The median serum amylase and lipase levels after the procedure were significantly lower in the EPS group than in the Non-EPS group (amylase: 104 vs. 262 U/L; p < 0.01, lipase: 102 vs. 666 U/L; p = 0.01). The use of EPS decreased the incidence of PEP after SEMS insertion in individuals with malignant distal biliary stricture and without MPD obstruction.
Keywords post-endoscopic retrograde cholangiopancreatography pancreatitis endoscopic pancreatic stent main pancreatic duct obstruction self-expandable metal stent distal biliary stricture
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 481
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361867
Web of Science KeyUT 000601203600003
NAID 120006948956
JaLCDOI 10.18926/AMO/61205
FullText URL 74_6_467.pdf
Author Yokota, Yuya| Nishimura, Yoshito| Ando, Akemi| Hanayama, Yoshihisa| Hasegawa, Kou| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio|
Abstract Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that the BAP/ALP ratios of the patients with fever and those with inflammatory diseases were significantly lower than the ratios of other patient groups. The BAP/ALP ratios of the patients with osteoporosis and those with metabolic bone diseases were higher than those of the patients with other conditions. The BAP/ALP ratio was found to be negatively correlated with age, a cor-relation that has not been found in other ethnicities. The serum BAP/ALP ratio was inversely correlated with serum CRP levels but was positively correlated with serum albumin levels and hemoglobin concentrations. Collectively, our results suggest that the BAP/ALP ratio could be a useful predictor for important geriatric con-ditions seen in general practice.
Keywords alkaline phosphatase BAP CRP inflammation osteoporosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 467
End Page 474
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361866
Web of Science KeyUT 000601203600002
NAID 120006948955
JaLCDOI 10.18926/AMO/61204
FullText URL 74_6_461.pdf
Author Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Abstract Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted.
Keywords gastric cancer young patients Helicobacter pylori
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 461
End Page 466
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361865
Web of Science KeyUT 000601203600001
NAID 120006948954
FullText URL fultext.pdf Fig 1.tif Fig 2.tif Fig 3.tif Fig 4.tif Suppl Fig.tif
Author Yamamoto, Haruchika| Yamamoto, Hiromasa| Soh, Junichi| Suzuki, Etsuji| Namba, Kei| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Yorifuji, Takashi| Takahashi, Katsuhito| Toyooka, Shinichi|
Note This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-020-09272-1.|
Published Date 2020-11-24
Publication Title Annals of Surgical Oncology
Volume volume28
Publisher Springer
Start Page 3884
End Page 3890
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
File Version author
PubMed ID 33236252
DOI 10.1245/s10434-020-09272-1
Web of Science KeyUT 000592170800006
Related Url isVersionOf https://doi.org/10.1245/s10434-020-09272-1
FullText URL fulltext.pdf
Author Minde, Mona W.| Madland, Merete V.| Zimmermann, Udo| Egeland, Nina| Korsnes, Reidar I.| Nakamura, Eizo| Kobayashi, Katsura| Ota, Tsutomu|
Keywords Mineral replacement reactions EOR Calcite FE-SEM FE-TEM
Published Date 2020-09
Publication Title Microporous and Mesoporous Materials
Volume volume304
Publisher Elsevier
Start Page 109402
ISSN 1387-1811
NCID AA11160707
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
DOI 10.1016/j.micromeso.2019.03.050
Web of Science KeyUT 000546913300015
Related Url isVersionOf https://doi.org/10.1016/j.micromeso.2019.03.050
FullText URL fulltext.pdf
Author Akita, Shinsuke| Unno, Naoki| Maegawa, Jiro| Kimata, Yoshihiro| Fukamizu, Hidekazu| Yabuki, Yuichiro| Shinaoka, Akira| Sano, Masaki| Kawasaki, Yohei| Fujiwara, Tadami| Hanaoka, Hideki| Mitsukawa, Nobuyuki|
Keywords Indocyanine green fluorescent lymphography Secondary lymphoedema Lymphaticovenular anastomosis
Published Date 2020-09
Publication Title Contemporary Clinical Trials Communications
Volume volume19
Publisher Elsevier
Start Page 100595
ISSN 2451-8654
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32617434
DOI 10.1016/j.conctc.2020.100595
Web of Science KeyUT 000594379900031
Related Url isVersionOf https://doi.org/10.1016/j.conctc.2020.100595
FullText URL fulltext.pdf
Author Nishida, Takashi| Kubota, Satoshi|
Keywords Mechanoreceptors Cellular communication network factor 2 (CCN2) Mechanical stress Chondrocytes
Published Date 2020-11
Publication Title Japanese Dental Science Review
Volume volume56
Issue issue1
Publisher Elsevier
Start Page 119
End Page 126
ISSN 1882-7616
NCID AA12334461
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 33088364
DOI 10.1016/j.jdsr.2020.07.001
Web of Science KeyUT 000598681800016
Related Url isVersionOf https://doi.org/10.1016/j.jdsr.2020.07.001
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Kuise, Takashi| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Tani, Yuma| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hanging maneuver Laparoscopic Liver resection
Published Date 2020-10-08
Publication Title International Journal of Surgery Case Reports
Volume volume76
Publisher Elsevier
Start Page 251
End Page 253
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 33053483
DOI 10.1016/j.ijscr.2020.10.002
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002
FullText URL fulltext.pdf
Author Nishizawa, Hitomi| Sato, Yoshihiko| Ishikawa, Masumi| Arakawa, Yuko| Iijima, Mari| Akiyama, Tomoyuki| Takano, Kyoko| Watanabe, Atsushi| Kosho, Tomoki|
Keywords Hypophosphatasia Alkaline phosphatase Genetic disease Asfotase alfa Recombinant gene therapy Motor function
Published Date 2020-12
Publication Title Molecular Genetics and Metabolism Reports
Volume volume25
Publisher Elsevier
Start Page 100643
ISSN 2214-4269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32983894
DOI 10.1016/j.ymgmr.2020.100643
Web of Science KeyUT 000600655200010
Related Url isVersionof https://doi.org/10.1016/j.ymgmr.2020.100643
FullText URL fulltext.pdf
Author Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Hiramatsu Asano, Sumie| Yamamura, Yuriko| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun|
Keywords Nephrology Rheumatology
Published Date 2020-10-30
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 18715
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33127957
DOI 10.1038/s41598-020-75655-9
Web of Science KeyUT 000591916900014
Related Url isVersionOf https://doi.org/10.1038/s41598-020-75655-9
FullText URL fulltext.pdf
Author Watanabe, Toshiyuki| Takabatake, Kiyofumi| Tsujigiwa, Hidetsugu| Watanabe, Satoko| Nakagiri, Ryoko| Nakano, Keisuke| Nagatsuka, Hitoshi| Kimata, Yoshihiro|
Keywords honeycomb β-TCP bone tissue regeneration bone microenvironment Vertical and Horizontal holes geometrical structure
Published Date 2020-10-25
Publication Title Materials
Volume volume13
Issue issue21
Publisher MDPI
Start Page 4761
ISSN 1996-1944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33113818
DOI 10.3390/ma13214761
Web of Science KeyUT 000589377800001
Related Url isVersionOf https://doi.org/10.3390/ma13214761
FullText URL fulltext.pdf
Author Tomiyama, Yasuaki| Shinohara, Tsugumichi| Matsuka, Mirai| Bando, Tetsuya| Mito, Taro| Tomioka, Kenji|
Keywords Circadian clock Clockwork orange Clock gene Cricket cry2 Molecular oscillation Locomotor rhythm
Published Date 2020-11-11
Publication Title Zoological Letters
Volume volume6
Issue issue1
Publisher BMC
Start Page 12
ISSN 2056-306X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
DOI 10.1186/s40851-020-00166-4
Web of Science KeyUT 000588683700001
Related Url isVersionOf https://doi.org/10.1186/s40851-020-00166-4