| ID | 11843 |
| JaLCDOI | |
| Sort Key | 12
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| Title Alternative | Relationship between intracellular uptake of adriamycin and membrane potential in ADR resistant Ehrlich ascites tumor cells
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| FullText URL | |
| Author |
Kawasaki, Shoji
Nishikawa, Koji
Shu Gao, Xian
Hiraki, Yoshio
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| Abstract | We observed adiamycin (ADR) uptake and cellular transmembrane potential [amount of intracellular fluorescence of 3,3'- (Di-n-hexyl)- 2,2'- oxacarbocyanine iodide (NK-2280)] in ADR-resistant cells established from Ehrlich ascites tumor cells (EATC) and wild type EATC. In ADR-resistant cells, ADR uptake and the cellular transmembrane potential decreased as the degree of resistance increased. 4,4'- diisothiocyanatostilbene- 2,2'- disulfonic acid (DIDS) induced markedly decreases of ADR uptake and the cellular transmembrane potential. A good correlation was observed between ADR uptake and transmembrane potential in cultured cells.
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| Keywords | Adriamycin
Cell Membrane Potential
Flow Cytometry
ADR-Resistant Cells
DIDS
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| Publication Title |
岡山大学医療技術短期大学部紀要
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| Published Date | 1993-01-31
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| Volume | volume3
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| Publisher | 岡山大学医療技術短期大学部
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| Publisher Alternative | School of Health Sciences Okayama University
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| Start Page | 81
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| End Page | 85
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| ISSN | 0917-4494
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| NCID | AN10355371
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| Content Type |
Departmental Bulletin Paper
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| OAI-PMH Set |
岡山大学
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| language |
Japanese
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| File Version | publisher
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| NAID | |
| Eprints Journal Name | fhs
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