ID | 67004 |
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Author |
Sugihara, Shinsuke
Department of Orthopedic Surgery, Shikoku Cancer Center
Nakahara, Ryuichi
Department of Orthopedic Surgery, Okayama University Hospital
Katayama, Haruyoshi
Department of Orthopedic Surgery, Okayama University Hospital
Itano, Takuto
Department of Orthopedic Surgery, Okayama University Hospital
Ozaki, Toshifumi
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
publons
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Abstract | Objective: Precise assessment of spinal instability is critical before and after radiotherapy (RT) for evaluating the effectiveness of RT. Therefore, we retrospectively evaluated the efficacy of RT in spinal instability over a period of 6 months after RT, utilizing the spinal instability neoplastic score (SINS) in patients with painful spinal metastasis. We retrospectively evaluated 108 patients who received RT for painful vertebral metastasis in our institution. Mechanical pain at metastatic vertebrae, radiological responses of irradiated vertebrae, and spinal instability were assessed. Follow-up assessments were done at the start of and at intervals of 1, 2, 3, 4, and 6 months after RT, with the pain disappearing in 67%, 85%, 93%, 97%, and 100% of the patients, respectively. The median SINS were 8, 6, 6, 5, 5, and 4 at the beginning and after 1, 2, 3, 4, and 6 months of RT, respectively. Multivariate analysis revealed that posterolateral involvement of spinal elements (PLISE) was the only risk factor for continuous potentially unstable/unstable spine at 1 month. In conclusion, there was improvement of pain, and recalcification results in regaining spinal stability over time after RT although vertebral body collapse and malalignment occur in some irradiated vertebrae. Clinicians should pay attention to PLISE in predicting continuous potentially unstable/unstable spine.
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Keywords | spinal metastases
spinal instability neoplastic score
radiotherapy
posterolateral involvement of spinal elements
risk factor
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Published Date | 2024-04-30
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Publication Title |
Cancer Control
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Volume | volume31
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Publisher | SAGE Publications
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ISSN | 1073-2748
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2024
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File Version | publisher
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PubMed ID | |
DOI | |
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Related Url | isVersionOf https://doi.org/10.1177/10732748241250219
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License | https://creativecommons.org/licenses/by-nc/4.0/
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Citation | Nakata E, Sugihara S, Nakahara R, Katayama H, Itano T, Ozaki T. Changes in Spinal Instability After Conventional Radiotherapy for Painful Vertebral Bone Metastases. Cancer Control. 2024;31. doi:10.1177/10732748241250219
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | 22K09401
23K08678
23K08698
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