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ID 16649
Eprint ID
16649
FullText URL
93_851.pdf 444 KB
Title Alternative
Studies on the antitumor activity of interferon II. Effect of interferon on human acute lymphoblastic cell lines grown in hamsters
Author
Lai, Miinyuh
Abstract
B-cell and T-cell human leukemic cell lines, BALL-1 and TALL-1, were transplanted into newborn hamsters immunosuppressed with rabbit anti-hamster lymphocyte serum. The growth inhibitory effect of interferon (IF) was tested by intraperitoneal administration in these tumor-bearing animals. The following results were obtained: (1) TALL-1 transplanted intraperitoneally was inhibited much more than BALL-1 transplanted subcutaneously. The life span of hamsters transplanted with TALL-1 was also prolonged. These findings coincided with the results of in vitro sensitivity of these two cell lines to IF. (2) The antiproliferative effect of a combination of cyclophosphamide and IF to BALL-1 was greatly enhanced compared with when either agent was used alone. (3) The combined use of L-asparaginase and IF was similarly more inhibitory to TALL-1 than either agent alone. It seems that the growth of residual tumor cells after chemotherapy can be effectively inhibited by IF. In using IF for cancer chemotherapy, therefore, it would be advisable to combine chemotherapeutic agents with IF.
Keywords
Interferon
Cyclophosphamide
L-asparaginase
Human ALL cell lines
Heterotrasplantation
Hamsters
Published Date
1981-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
851
End Page
859
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/9-10/93_9-10_851/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
Japanese
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma