ID | 16649 |
Eprint ID | 16649
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FullText URL | |
Title Alternative | Studies on the antitumor activity of interferon II. Effect of interferon on human acute lymphoblastic cell lines grown in hamsters
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Author |
Lai, Miinyuh
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Abstract | B-cell and T-cell human leukemic cell lines, BALL-1 and TALL-1, were transplanted into newborn hamsters immunosuppressed with rabbit anti-hamster lymphocyte serum. The growth inhibitory effect of interferon (IF) was tested by intraperitoneal administration in these tumor-bearing animals. The following results were obtained: (1) TALL-1 transplanted intraperitoneally was inhibited much more than BALL-1 transplanted subcutaneously. The life span of hamsters transplanted with TALL-1 was also prolonged. These findings coincided with the results of in vitro sensitivity of these two cell lines to IF. (2) The antiproliferative effect of a combination of cyclophosphamide and IF to BALL-1 was greatly enhanced compared with when either agent was used alone. (3) The combined use of L-asparaginase and IF was similarly more inhibitory to TALL-1 than either agent alone. It seems that the growth of residual tumor cells after chemotherapy can be effectively inhibited by IF. In using IF for cancer chemotherapy, therefore, it would be advisable to combine chemotherapeutic agents with IF.
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Keywords | Interferon
Cyclophosphamide
L-asparaginase
Human ALL cell lines
Heterotrasplantation
Hamsters
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Published Date | 1981-10-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume93
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Issue | issue9-10
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 851
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End Page | 859
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/93/9-10/93_9-10_851/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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