result 1964 件
| JaLCDOI | 10.18926/40413 |
|---|---|
| Title Alternative | STUDIES ON THE AGING OF MINERAL WATERS (II) CHANGES IN THE SILICATE CONTENT OF THERMAL WATERS OF MISASA AFTER FLOWING OUT |
| FullText URL | pitsr_011_014_018.pdf |
| Author | Sugihara, Takeshi| |
| Abstract | The author determined the silicate content of the thermal water of Hisui-no-Yu, Misasa, Tottori Prefecture, Japan, at varying times after flowing out, and obtained the following results: 1) The change in the silicate content after flowing out is at first remarkable. 2) The velocity of the changes in the silicate content has a tendency to be faster in the sample that is kept in the vessel with a wide water surface than in the one that has a smaller surface. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-06 |
| Volume | volume11 |
| Start Page | 14 |
| End Page | 18 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40410 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002509298 |
| JaLCDOI | 10.18926/40403 |
|---|---|
| Title Alternative | CHEMICAL STUDIES ON THE SPRINGS IN SANYO DISTRICT (II) |
| FullText URL | 010_003_009.pdf |
| Author | Sugihara, Takeshi| |
| Abstract | The author determined the radon contents of spring waters in the eastern part of Hiroshima Prefecture. In this district granite is distributed, and radon was found in most of the spring waters, although their content was variable. The results are as follows: 1) The highest radon content was 172 Mache (626×10(-10) Curie/ℓ) of Harada Spring. Such a high mdon content is rare in the spring waters of Sanyo District. 2) Kanae Spring showed 73.2 Mache (266.4×10(-10) Curie/ℓ) and the well waters near by it showed also comparatively high radon content. 3) The radon contents of the springs of Niwakayama, Immyoseki and No.1 of Hongo, and Takasu water were 44.6 (162.3), 23.2 (84.5), 7.5 (27.3) and 14.7 (53.5) Mache (×10(-10) Curie/ℓ) respectively. 4) The radon contents of rain, river and sea waters could not be determined by the I. M. fontactoscopeon account of its low values. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-03 |
| Volume | volume10 |
| Start Page | 3 |
| End Page | 9 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40400 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532421 |
| JaLCDOI | 10.18926/40384 |
|---|---|
| Title Alternative | CHEMICAL STUDTES ON THE RIVER WATERS IN THE INFECTED LOCALITIES WITH KATAYAMA-DISEASE (II) |
| FullText URL | 009_043_048.pdf |
| Author | Sugihara, Takeshi| Akashi, Tsutomu| Yokoi, Shin| |
| Abstract | In the previous report, one of the authors, T. Sugihara, discussed the results of chemical analysis of waters in the infected localites with Katayama-disease in the whole neighbourllood of Kannabe-cho, Fukayasu-distriict, Hiroshima-Prefecture. In this report, the authors discussed the results obtained in Yamanashi prefecture, and in the area drained by Chikugo River, and found the following facts: 1) The amount of KMnO(4) consumed and the copper content were high as in the previous report. 2) The calcium content was 7.3~22.2 mg/ℓ in the river waters of this report, but it was 18.7~38.2 mg/ℓ in the waters in the places of the previous paper. And in the previous report the author pointed out that the calcium content was fairly higher in the waters in the infected localities with Katayama disease than in the non-infected localities. But as the calcium content was relatively lower this time than in the previous investigation, more research is intended to reach definite conclusion. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-01 |
| Volume | volume9 |
| Start Page | 43 |
| End Page | 48 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40388 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532516 |
| JaLCDOI | 10.18926/40376 |
|---|---|
| Title Alternative | STUDIES ON THE CHLORIDE AND SULFATE CONTENT OF WELL WATERS AND THE AMOUNTS OF CHLORIDE AND SULFATE FIXED TO THE SOIL IN THE MINERAL SPRING DISTRICTS (II) SEKIGANE HOT-SPRINGS, TOTTORI PREFECTURE, JAPAN |
| FullText URL | 009_006_009.pdf |
| Author | Umemoto, Shunji| |
| Abstract | In Sekigane Hot-Springs, the chloride and sulfate content and water temperatures of well waters and the amounts of chloride and sulfate fixed to the soil were determined with the samples collected from the various parts of the thermal spring district and its neighbourhood. The chloride and sulfate content of the well water samples collected from the thermal spring district were higher than those from its neighbourhood, and no difference was found for the water temperatures. The amonnts of chloride fixed to the soil in the samples collected from the thermal spring district were greater than those from its neighbourhood, and the amounts of sulfate in the samples collected from the thermal spring district were extremely greater than those from its neighhourhood. As the existence of other sources which would supply the chloride and sulfate to the water and soil is not expected, the difference in the chloride and sulfate content and water temperatures, between the sa.mples from the thermal spring district and its neighbourhood, seems to be due to the effects of thermal springs. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-01 |
| Volume | volume9 |
| Start Page | 6 |
| End Page | 9 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532512 |
| JaLCDOI | 10.18926/40341 |
|---|---|
| FullText URL | pitsr_013_001_005.pdf |
| Author | Umemoto, Shunji| |
| Abstract | Various colormetric methods for determining magnesium in natural waters have been studied, and the methods using 8-oxyquinolin, ammonium molybdate and titan yellow were studied most frequently(1)), following the studies on the interfering ions(2)). Brilliant yellow(3)), l-amino-2-naphthol-6-sulfonic acid(4)) and other new reagents were also used. E. D. T. A. was used, but the determination by using this reagent is not exact. Present reagent already reported by T. Ashizawa(5)), magneson II, is insoluble in water, soluble in alkali and hardly soluble in ethanol. In the existence of magnesium ion, the color of solution varies from pink-violet (in alkali) and orange (in ethanol) to blue-violet. This variation of color was evaluated photometrically by Shimadzu photoelectric spectrophotometer, and moreover the grades of interference by interfering ions were clarified. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-12 |
| Volume | volume13 |
| Start Page | 1 |
| End Page | 5 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40340 |
| language | English |
| File Version | publisher |
| NAID | 120002484877 |
| JaLCDOI | 10.18926/40332 |
|---|---|
| Title Alternative | MEDICAL STUDIES ON THE RURAL PEOPLE (II) A STUDY ON THE INCIDENCE OF STRUMA IN THE SOUTH-WESTERN RURAL DISTRICTS OF OKAYAMA PREFECTURE, JAPAN |
| FullText URL | pitsr_014_051_056.pdf |
| Author | Morinaga, Hiroshi| |
| Abstract | The author investigated the thyroid glands of 1480 school children (aged from 6 to 14) living in the vicinity of Yakage, the south-western rural district of Okayama Prefecture, and 1516 out-patients of Yakage Hospital, in 1950. The incidence of struma among the school children was 4.6 per cent and among the out-patients 4.7% on an average, and the percentage of struma in the spring (7.8%) was higher than in the summer (2.98%). This result suggests that thyroid glands are in some way susceptible to seasonal influences, and it is therefore necessary to consider the effect of season during investigation. The white blood pictures of seven patients showed no specific findings. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1954-03 |
| Volume | volume14 |
| Start Page | 51 |
| End Page | 56 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462907 |
| JaLCDOI | 10.18926/40322 |
|---|---|
| Title Alternative | THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I) |
| FullText URL | 016_035_048.pdf |
| Author | Morinaga, Hiroshi| |
| Abstract | The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)～455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55～90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2～6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30～3.47mg./dl. , 5% rejection limit -- 1.97～3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78～108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1956-01 |
| Volume | volume16 |
| Start Page | 35 |
| End Page | 48 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532470 |
| JaLCDOI | 10.18926/40315 |
|---|---|
| Title Alternative | OUR EXPERIENCES OF INTRAARTICULAR HYDROCORTISONE INJECTION AND SPA TREATMENT FOR RHEUMATOID ARTHRITIS AND ARTHROSISDEFORMANS |
| FullText URL | 017_019_032.pdf |
| Author | Nakahara, Yasuhiro| Izumi, Tomokuni| |
| Abstract | 1. We classified 89 cases of rheumatoid arthritis and arthrosis deformans according to Prof. T. Kodama's criteria as follows: 33 cases of (222) polyarthritis systemica (37%), 15 cases of (221) polyarthritis non systemica (16.8%) 22 cases of (111) monoarthrosis non systemica (24%), and others. 2. We analysed their symptoms following the criteria recommended by the New York Rheumatism Association and Prof. T. Kodama. In many cases of (222), their local and general symptoms were found to belong to Class III or IV, and in many cases of (111) and (221), to Class I or II. This shows that (222), here treated, was severer than (111) and (221) in both local and general conditions. The hepatic disorder and anemia were found to occur in patients with (222). 3. We treated these 89 cases chiefly by spa therapy and intraarticular injection of hydrocortisune, and evaluated the results by the criteria recommended by N. Y. R. A. and Prot. T. Kodama. Each of these treatments was more effective on (111), (121), and (221) than on (222). In all cases, the combined treatment with the said two measures was more efficacious than the separate treatment with each of the two. 4. The effects of the intraarticular hydrocortisone injections, 686 in total and mostly into knee joints, were examined. The most efficacious of these were obtained when the injection was made into fingers, toes or hip joints. In our experiences, the post-injection flare ups and the adverse effects of the treatments were observed in 2.8% of the cases treated, but they lasted only for a few days. 5. Of five cases of (222), where the combined treatment of hydrocortisone intraarticular injection and spa therapy was given for 5-14 months, detailed descriptions are given. By this treatment the physical abilities in joints of patients were improved remarkably and their general conditions were ameliorated gradually without any adverse effects. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1956-03 |
| Volume | volume17 |
| Start Page | 19 |
| End Page | 32 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532476 |
| Author | 坪井 誠太郎| |
|---|---|
| Published Date | 1957-03 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume18 |
| Content Type | Others |
| JaLCDOI | 10.18926/40265 |
|---|---|
| Title Alternative | Studies on Paper-Analysis in the Field of Balneology (I) Studies on Iron in Serum by Means of Parper-Electrophoresis and Paper-Chromatography |
| FullText URL | 022_037_054.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | 1. The author showed by means of paper-electrophoresis using o-nitrosoresorcinmonomethylether (hereafter N. R. M. E.), a colourdeveloping reagent, that iron in serum combines with β-fraction of serum protein. 2. The author proposed a new method for the determination of serum iron by means of paper-chromatography. Procedure is as follows. In a centriguged tube, 0.5 ml. of clear serum is taken, acidified with 0.15 ml. of 20% HNO(3), and allowed to stand for 20 minutes. After addition of 0.2 ml. of saturated solution of CH(3)COONa and 1 ml. of acetic acid-sodium acetate buffer solution (pH: 3.8), the mixture is kept for at least 10 min. and filtered through Toyo-filter-paper No.5 A. The clear filtrate is taken in a stoppered test tube (the inside diameter: 1.2 cm.; height: 15 cm.). To this filtrate are added 0.2 ml. of 20% Hydroxylamine hydrochloride and 0.25 ml. of saturated aqueous solution of N. R. M. E. After being allowed to stand for at least 20 min., the mixture is shaken with 5 ml. of carbon tebrachloride. Then the excess of N. R. M. E. is removed. The supernatant aqueous solution (0.2 ml.) is used for a determination sample. The sample is placed on the paper (Toyo,filter-paper No.51 or 50) in a thin line at a distance of 10 cm. from the edge, and the spots are developed with 90 % ethylalcohol. After development for 4-6 hours, a green-coloured linear spot appsars at a distance of 12-16 cm. from the origin-point. Spot intensity at 670 mμ is measured with Natsume's densitometer, and from this, concentration of Fe can be estimat.ed on the standard graph (Fig. 5). 3, Effects of radioactive thermal spring bathing and internal use of vitriol water upon serum iron levels were studied with the result.s as follows. The above-mentioned author's method of determining the iron level in a small amount of serum is very convenient in investigating iron metabolism in the field of balneotherapy. The author examined changes of iron levels in serum after radioactive thermal bathing as well as after internal use of acid vitriol water. a) The iron levels in serum were maasurecl by the author's method before and 5, 30 and 60 minutes after the radioactive thermal bath (Rn-content: 10-30 Mache, 42-3°C., for 10 min,). The iron levels in the serum of healthy subjects showed no significant change after the thermal bathing. b) Yanahara Mineral Water (an acid vitriol water, pH; 2.2) contains 0.045 gm. of Cl(-), 12.35 gm. of SO(4)(--), 2.5 gm. of Fe(++)+Fe(+++), 0.0938 gm. of Al(+++) and 0.0001 gm. of Cobalt in one liter. i) Thirty ml. of Yanahara, water diluted with plain water to 200 ml. (Fe(++) content: ca. 75 mg.) and administered to health fasting subjects orally. As a control matter, 0.65 gm. of Glukon-F powder (Fe(++) content.: ca. 75 mg.) was then given. Blood samples were taken from the cubital vein before and 1, 3 and 6 hours after the intake of the dtriol water. Iron contents of the serum samples were measured by the author's paper chromatographic method. The results were shown in the table and the figure. The iron contents of the serum after the intake of the mineral water were higher than in the case of the control. ii) Two ml. of Yanahara vitriol water was administered to rabbits with the aid of a stomach tube, and serum iron levels wera determined before and 1, 3, 4 and 6 hours after the administration. An amount of 0.05 gm. of Glukon-F powder was dissolved in 5 ml. of plain water, and this solution was given to rabbits as a control. After the internal use of vitriol water, iron levels in serum rose and remained unexpactedly high for about 1-4 hours, in a manner that did not. correspond to the amount of iron in the given mineral water. So that it was suspected that the iron originally contained in the living subjects had been mobilized by the intake of vitriol water. Iron levels in serum after administration of a solution of Glukon-F powder were lower than in the case of the mineral water. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-07 |
| Volume | volume22 |
| Start Page | 37 |
| End Page | 54 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40263 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532359 |
| JaLCDOI | 10.18926/40253 |
|---|---|
| Title Alternative | Studies on Paper-analysis in the Field of Balneology. (3) The Changes of the Serum Protein Fractions and Lipoprotein Fractions Following the Bathing in Radioactive Hot Spring |
| FullText URL | 024_054_079.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | I. Some fundamental conditions and procedures on filter-paper electrophoresis were investigated. The electrophoretic apparatus of Natsume Seisakusho and Toyo No. 51 filter-paper were used. Electrophoresis was carried out under the current of 0.25 mA/cm. in 300 Volt during 5 hours, using veronal buffer pH 8.6 (μ=0.05). In measuring of serum protein fractions, the adequate volume of the materials loaded is in the range of 0.005～0.01 ml. and in the case of lipoprotein, 0.02 ml. of serum is used. Paper-strip was stained with bromophenol blue or sudan black B, then making it transparent with heat-solved paraffin and photometered by Nataume's densitometer. The reproducibility of the above-mentioned method with a confidence of 99% was as follows: Serum protein fractions Albumin 53.4±1.8% α(1)-Globulin 3.3±0.3 α(2)-Globulin 6.0±0.5 β-Globulin 12.2±0.7 γ-Globulin 25.1±1.1 Serum lipoprotein fractions α 20.6±2.6% β+γ 79.4±2.6 II. Changes in serum protein fractions and lipoprotein fractions following the radioactive hot spring bathing were as follows: 1). In rabbits, the albumin-fraction of serum protein increased after a series of baths in radioactive hot spring, and the β- and γ-globulin-fractions decreased. 2). By cholesterol-feeding, the albumin-fraction of serum protein of rabbits decreased and the β- and γ-globulin-fractions increased significantly but when a series of baths was carried out in cholesterol-fed rabbits the decrease in the albumin-fraction was slighter than the former. 3). α-globulin-fraction of serum lipoprotein increased after single bathing in radioactive hot spring and (β+γ) -globulin-fractions showed an inverse change, but the changes of lipoprotein-fractions following a series of baths were not remarkable. 4). By cholesterol-feeding, the ratio of lipoprotein-fractions (β+γ/α) increased, but the ratio tended to decrease following a series of baths in radioactive hot spring. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 54 |
| End Page | 79 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532366 |
| JaLCDOI | 10.18926/40252 |
|---|---|
| Title Alternative | Studies on Paper-analysis in the Field of Balneology. (II) 1. A New Method for the Determination of Cobalt in Blood. 2. Effects of Radioactive Thermal Bathing and Internal Use of Vitriol Water upon Cobalt Levels in Blood. |
| FullText URL | 024_029_053.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | 1. A new method for the determination of cobalt in blood. The author proposed a new method for the determination of cobalt in blood by means of paper-chromatography. The procedure is follows. In a Kjeldahl colben, 5 m!. of blood is taken, and turned into wet ash with 3 ml. of HNO(3), 0.5 ml. of H(2)SO(4) and 1.5 ml. of HClO(4) and the ash aqueus solution is then neutralized with ammonium hydroxid, the neutralization being indicated by the development of color of 0.1% of p-nitrophenol (one drop) added to the solution. After addition of 2 ml. of 40% ammonium citrate, 0.5 ml. of 20% Na(2)S(2)O(3), 3～5 drops of H(2)O(2) and 1 ml. of o-nitrosoresorcine monomethyl ether (hereafter N.R.M.E.), the mixture is left for at least 15 minutes and the aqueus solution is taken in a stoppered test tube (inside diameter: 1.3 cm., hight: 16.5 cm.). The mixture is shaken with 2 ml. of carbon tetrachloride. Carbon tetrachloride is shaken with 5 ml. of 20% Na(2)CO(3) solution. Then the excess of N.R.M.E. is removed and carbon tetrachloride is concentrated on water bath to 0.3～0.5 ml. and all CCl(4) is used for a determination sample. The sample is placed on the paper (Toyo-filter paper No. 50 or 51A) in a thin line at a distance of 3 cm. from the edge, and the spot is developed with a mixture of 20 ml. of CCl(4) and 1 ml. of 90% ethylalcohoI. After development for 30～40 min., an orange-colored linear spot appears at a distance of 9～10 em. from the origin point. Spot intensity is measured at 460 mμ with Natsume's densitometer and quantitative estimation is made comparing with the standard graph. 2. Effects of radioactive thermal spring bathing and internal use of vitriol water upon cobalt levels in blood. As the author's method above-mentioned is able to determine the cobalt level in a small amount of blood, it is very convenient in investigating cobalt metabolism in the field of balneology. The author examined the changes of cobalt levels in blood after radioactive thermal bathing as well as after internal use of acid vitriol water. a. By the author's method cobalt in normal human blood was 0.4～3.6γ/100ml. in man (average: 1.6±0.4γ/100ml.) and 0.2～2.2γ/100ml. in woman (average: 0.7±0.3γ/100ml.). b. The cobalt levels in blood were measured by the author's method before and 5, 30, 60 minutes after the radioactive thermal single bathing, and before and 1, 2, 3, 4 weeks after a series of radioactive thermal baths (Rn-content: 10～30 Mache, 42～3°C., for 10 minutes). The cobalt levels in the blood of healthy subjects showed no significant change after the thermal single bathing, but those of patients with rheumatoid arthritis showed a slight increase on 3rd or 7th day and a fall on 2nd week of a series of radioactive thermal baths and then tended to return to the initial levels during the 3rd and 4th weeks of spa treatment. c. Thirty ml. of Yanahara mineral water (an acid vitriol water, pH: 2.2) was diluted with plain water to 200 ml. (Co(++)content: ca.3γ) and administered to healthy fasting subjects orally. Blood samples were taken from the cubital vein before and 1, 3, 6 hours after the intake of the vitriol water. The cobalt levels in the blood showed an increase of 14% of the initial levels at 1 and 3 hours and a decrease of 22% at 6 hours after the drinking of Yanahara mineral water. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 29 |
| End Page | 53 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532366 |
| JaLCDOI | 10.18926/40241 |
|---|---|
| Title Alternative | Clinical Studies on Anemia in Rheumatoid Arthritis (II) |
| FullText URL | 026_031_049.pdf |
| Author | Yamamoto, Yasuhisa| |
| Abstract | II. Iron Metabolism 1. The serum iron: The serum iron was estimated by the method of Umemoto and Yamamoto (by means of o-nitroso resorcinmonomethylether) The average serum iron level of 33 cases with rheumatoid arthritis was 47γ/100 ml., and in 27 of 33 cases (82%) the serum iron levels were shown to be below the lower limit of the normal range (5% rejection limit: 54-141γ/100 ml. ), but the concentrations of serum iron of neuralgias (degenerative Spondylosis, sciatica and painful shoulder) were mostly within the normal range. 2. Iron absorption: To investigate the possible role of poor absorption in preventing a response to oral iron therapy, the changes in serum iron were followed after a test of iron by mouth in 16 caseS with rheumatoid arthritis. The test dose was 1 gm. of reduced iron given with 30 mI. of lemonade-pepsin solution to preserve the iron in the ferrous state and obviate the effects of possible achlorhydria in rheumatoid patients. The results may be grouped under three headings: a) Large rise in serum iron: good adsorption. Three caseS (19%) showed a very large rise in serum iron after the test dose, which is similar to simple iron-deficiency anemia. b) Slight rise in serum iron: presumed poor absorption. Six cases (38%) showed a very small or negligible rise after the test dose, so that at its peak the serum iron was below the normal range. c) In the remaining 7 cases, a maximal rise in serum iron after the test dose was within the normal range. 3. The iron-binding capacity of the serum: The iron-binding capacity of the serum was estimated by means of intravenous injection of Gluferricon (Fe content: 10 mg.). The mean total iron-binding capacity of the serum in the present 13 cases with rheumatoid arthritis was 273γ/100ml., virtually the same as the normal figure (287γ /100 ml.). The degree of saturation of the iron-binding protein with iron was found to lie between 18 and 45% (average: 34%) in control sUbjects and between 7 and 24% (average: 16%) in rheumatoid patients. 4. The serum copper: The serum copper was estimated by means of diethyldithiocarbamate in rheumatoid arthritis with the following results. Healthy subjects: men (15 cases): mean 89.9±14.8γ /l00 ml., women (15 cases): mean 99.9± 12.6γ/100 ml. There is no significant difference between the two. In 10 of 17 cases (57%) with rheumatoid arthritis, the serum copper levels were shown to be above the upper limit of the normal range (57-138γ/100 ml. ・・・5% rejection limit), neuralgias were mostly (92%) within the normal range. The results of investigations upon alternations in iron metabolism of rheumatoid anemia are reported. 1. The serum iron concentration was usually reduced. 2. The intestinal absorption of iron after a single dose of 1 gm. of reduced iron was variable. Strong presumptive evidence of impaired absorption waS recognised in many cases, but some cases gave the excellent absorption. From these results, it seems that simple iron deficiency exist in some anemic caseS of rheumatoid arthritis. 3. The total iron-binding capacity of the serum was slightly reduced. 4. The degree of Saturation of iron-binding protein with iron was below nornal. 5. The serum copper concentration waS usually elevated. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-10 |
| Volume | volume26 |
| Start Page | 31 |
| End Page | 49 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/40239 |
|---|---|
| Title Alternative | Clinical Study on the Treatment of Rheumatoid Arthritis Part II. Experiences of Intraarticular Injection of Prednisolone for Rheumatoid Arthritis |
| FullText URL | 026_008_019.pdf |
| Author | Izumi, Tomokuni| |
| Abstract | Meticorterone (Prednisolone acetate) were injected into joints of 33 cases of rheumatoid arthritis, 172 times in total, with better results. Although intraarticular injection of prednisolone is, at present, to be one of the most effective treatment for rheumatoid arthritis, one must pay attention at the appearance of general effect in frequent and abundant injection. Comparative studies were performed on the effects of intraarticular injectons of prednisolone T. B. A, (on twelve cases), hydrocortisone acetate and meticorterone. Prednisolone T. B. A. was proved markedly longer effect in local with minimum general effect, It was, therefore, thought that prednisolone T. B. A. was safest and most effective in intraarticular therapy on the rheumatoid arthritis. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-10 |
| Volume | volume26 |
| Start Page | 8 |
| End Page | 19 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/40194 |
|---|---|
| Title Alternative | Epidemiological research of radioactive springs (Misasa Hot Springs) on circulatory systems. II. Incidences of abnormal ECG findings and hypertension (A preliminary report) |
| FullText URL | pitsr_036_001_005.pdf |
| Author | Kitayama, Minoru| Matoba, Kunikazu| |
| Abstract | Misasa Hot Springs water contains 4.81-1169.2×10(-10) curie per liter of radon and its temperature ranges from 53.0℃ to 76.0℃. The authors examined one group of 265 residents who are living over 1 year at Misasa Hot Springs and another control group of 226 residents at the middle district of Tottori Prefecture, where the Misasa area is singular for its high radon concentration. A living environment of these two groups is of same condition, for example, dietarily or economically. The incidences of abnormal ECG findings and hypertension in the both groups was analysed stochastically and the results obtained were as follows: 1. The incidences of abnormal ECG findings were found less in the residents at the radioactive hot springs area than another residents at the middle district of Tottori Prefecture. 2. The difference in these incidences were found especially about the ECG findings due to functional disorderes, for example, sinus tachycardia and bradycardia, premature supraventricural and ventricural systole, atrio-ventricural block and right bundle branch block. 3. The ECG findings due to organic disorderes, for example, both auricural and ventricural hypertrophy or strain, myocardial and coronary arterial lesions, auricural fibrillation and left bundle branch block, were not found different significantly between both groups. 4. No difference of the incidences of the functional and organic abnormal ECG findings between both aging groups, over 60 years old, were found. 5. The incidences of hypertension were not found different between both groups. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1966-10-25 |
| Volume | volume36 |
| Start Page | 1 |
| End Page | 5 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002400931 |
| JaLCDOI | 10.18926/40178 |
|---|---|
| Title Alternative | Study on effects of balneotherapy on blood pH, P(CO(2)) and P(O(2)) Part 2. Relationships between the physiopathological factors and blood pH, P(CO(2)) and P(O(2)) |
| FullText URL | 038_011_025.pdf |
| Author | Yahata, Takaaki| |
| Abstract | From the factors which are considered to make an effect on circulatory or metabolic states, hemoglobin content, erythrocyte sedimentation rate, room temperature, respiratory rate and pulse rate were chosen to be discussed their relationships between the pH, P(CO(2)) and P(O(2)). Moreover, changes due to age and disease as well as diurnal and seasonal variations of blood pH, P(CO(2) and P(O(2)) were evaluated. 1) Blood pH and Peo2 showed the tendency of reduction in the order of 40~59, 10~39 and 60~79 years age group in the former and in the latter 40~59, 60~79 and 10~39 years age group. The P(O(2)) value in the afternoon decreased with ageing. However, no significance was demonstrated in any age group. 2) Diurnal changes of pH in 10~59 age group was very small. In the 60~79 age group, the afternoon value decreased than the morning one. The P(O(2)) value in the 10~59 age group increased in the afternoon contrasted to the decreasement in the 60~79 age group. The P(CO(2)) variations in all age groups were within the errors due to the measurement. 3) Rheumatiod arthritics group showed no significant diurnal variation different from non-rheumatoid arthritics group. 4) Blood pH of December-February group showed the lowest seasonal value and significant difference between March - May and September - November group. No significant seasonal variation was observed in the blood P(CO(2)) and P(O(2)). 5) The central nervous system group showed the significant lower blood pH than cardiovascular disease and rheumatoid arthritis group. The P(CO(2)) values of rheumatoid arthritis group were lower significantly than cardiovascular disease, central nervous system, and musculo- keletal system patient groups. None of diseases showed significant P02 difference each other. 6) Significant relationship was demonstrated between erythrocyte sedimentation rate and P(O(2)) value only in cardiovascular disease patient group. 7) There were the significant relationships between room temperature and P(O(2)) in rheumatoid arthritis and metabolic disease groups. 8) Significant relationships were shown between respiratory rate and pH in rheumatoid arthritis and cardiovascular disease groups. 9) There was significant relationship between pulse rate and pH only in rheumatoid arthritis groups. 10) The combination of the blood pH, P(CO(2)) and P(O(2)), values was shown to reflect the circuratory or metabolic states of the tissues or organs and to remain stable on the experimental day. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1969-03-20 |
| Volume | volume38 |
| Start Page | 11 |
| End Page | 25 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532343 |
| JaLCDOI | 10.18926/40170 |
|---|---|
| Title Alternative | Study on the conbined therapy of spa and gold salt in rheumatoid arthritis Part II. An experience of granulocytopenia possibly caused by gold salt preparation |
| FullText URL | pitsr_039_037_042.pdf |
| Author | Ikegami, Tadaoki| Yahata, Takaaki| Kitayama, Minoru| Morinaga, Hiroshi| |
| Abstract | A thirty seven years old woman with rheumatoid arthritis was instituted gold salt intramuscularly twice a week on the nineteenth hospital day. On the fifty fourth day, however, it was discontinued at the total dosis of 180 mg because of the skin rush. In about ten days after stopping gold injection appeared high fever with shivering and granulocytopenia was demonstrated. With immediate administration of ACTH, adrenocortical hormons etc. including blood transfusion the abnormal findings of the blood pictures returned to normal and the patient became well. Recently, gold salts are so widely used in treatment of rheumatoid arthritis as one of specific antirheumatic agents that the possible severe side effect such as granulocytopenia, if quite rare, should always be considered in the course of gold therapy. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1970-03-30 |
| Volume | volume39 |
| Start Page | 13 |
| End Page | 35 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/40169 |
|---|---|
| Title Alternative | Clinical studies on electromyographic changes in rheumatoid arthritis Part II. Electromyographic changes in treated rheumatoid arthritis during 3 months after admission |
| FullText URL | 039_013_035.pdf |
| Author | Ikegami, Tadaoki| |
| Abstract | Electromyograms were recorded on 15 patients with rheumatoid arthritis (12 cases of classical rheumatoid arthritis and 3 cases of definite rheumatoid arthritis) and 5 cases of healthy controls. The muscles selected were the biceps brachii, opponens pollicis and abductor pollieis brevis, and following results were obtained: 1) The amplitude and mean potential duration in rheumatoid arthritis were less than controls, the differences being statistically significant. 2) Electromyographic evidence of myogenic atrophy was demonstrated in the small hand muscles and proximal muscles. 3) Myogenic atrophy due to steroid therapy was considered in proximal muscles, while the small hand muscles were affected more rarely. 4) Myogenic atrophy in stage III-IV were less than those in stage I-II, but in the m. opponens pollicis there were little differences. 5) Myogenic atrophy in inactive rheumatoid arthritis were significantly less than those in active, but in the m. opponens pollicis no marked changes were observed. 6) Myogenic atrophy of the m. opponens pollicis were more than that of m. abductor pollicis brevis. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1970-03-30 |
| Volume | volume39 |
| Start Page | 13 |
| End Page | 35 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398497 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| FullText URL | 64_4_213.pdf |
| Author | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| Abstract | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| Keywords | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-08 |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |
| Author | 岡山大学埋蔵文化財調査研究センター| |
|---|---|
| Published Date | 1990-03-31 |
| Publication Title | 岡山大学構内遺跡発掘調査報告 |
| Volume | volume4 |
| Content Type | Research Paper |
