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JaLCDOI 10.18926/OER/66033
Title Alternative Building a perspective on the innovation process of local public services
FullText URL oer_055_2_001_014.pdf
Author Fujii, Daiji| Kanaji, Hiroshi|
Abstract  When local governments develop public services, they often experience innovation processes. More often, the innovation processes referred to here seem to be the perceived needs for transformation faced with external pressures and the purposive responses to them. This article tries to depict this discourse from a different viewpoint. One of the perspectives that has been proposed so far is that the external environments are made up of multiple actors, and that the historical backgrounds and the relationships between these actors affect the structure of administrative organizations and the methods of providing public services. The transformation processes could be one-time events no matter how long the processes may take, but this article tries to argue they may connote a circular mechanism where both of the administrative organizations and the external actors feedback to each other. In order to elaborate this direction of theorizing, three steps are employed by applying existent literature of various types developed in rather a broader context of social sciences. First, if one of the goals of postmodern theorization is liberating the psychological energies of actors from the cramped social reality that structuralists postulated, then Actor-Network-Theory may be useful. Second, according to Sarasbathy’s research on entrepreneurial behaviors, the view that we effectuate our future through what we can do now is attractive in order to create a new discourse of social innovations, where we appreciate them as not springing out of nowhere all of sudden. Third, once this article accepts polyphonic views on social realities where congested discourses interact during abovementioned process, the role of civic entrepreneurs on the frontline can never be overstated enough. This is because such civic entrepreneurs could cooperate with minority opinions and raise them into broader contexts of dialogues within societies.
Keywords local government public services innovation process
Publication Title Okayama Economic Review
Published Date 2023-11-24
Volume volume55
Issue issue2
Start Page 1
End Page 14
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2023 岡山大学経済学会
File Version publisher
FullText URL fulltext.pdf
Author Tomita, Koji| Matsui, Yusuke| Uka, Mayu| Umakoshi, Noriyuki| Kawabata, Takahiro| Munetomo, Kazuaki| Nagata, Shoma| Iguchi, Toshihiro| Hiraki, Takao|
Keywords Ablation Liver Metastasis
Note The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-022-01335-5|
Published Date 2022-09-13
Publication Title Japanese Journal of Radiology
Volume volume40
Issue issue10
Publisher Springer Science and Business Media LLC
Start Page 1035
End Page 1045
ISSN 1867-1071
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36097234
DOI 10.1007/s11604-022-01335-5
Web of Science KeyUT 000852956100003
Related Url isVersionOf https://doi.org/10.1007/s11604-022-01335-5
JaLCDOI 10.18926/AMO/65978
FullText URL 77_5_545.pdf
Author Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki|
Abstract To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
Keywords esophagogastroduodenoscopy gastric lesion amyloidosis light chain
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 545
End Page 552
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899266
Web of Science KeyUT 001094245100001
JaLCDOI 10.18926/AMO/65975
FullText URL 77_5_527.pdf
Author Ando, Miho| Hanayama, Yoshihisa| Nishimura, Yoshito| Hagiya, Hideharu| Otsuka, Fumio|
Abstract Retroperitoneal fibrosis (RPF) is a rare cause of hydronephrosis and progressive renal dysfunction with unidentified origin. RPF is categorized into idiopathic RPF with/without immunoglobulin G4 (IgG4)-related disease (IgG4-RD), and secondary RPF. Identifying the underlying cause is challenging and often associated with delayed diagnosis or therapeutic interventions. We investigated RPF’s clinical characteristics based on different etiologies and factors that may help distinguish the underlying causes. We analyzed the cases of 49 patients with RPF that was radiographically diagnosed at our institution (2008-2022). The cohort was 77.6% males; 75.5% had idiopathic RPF and 24.5% had secondary RPF. Among the idiopathic patients, 54.1% had IgG4-RD. The patients were likely to have abdominal pain, lower back pain/lumbago, and constitutional symptoms including generalized fatigue and fever. The idiopathic patients were likely to have higher serum IgG4 and IgG levels and lower serum C3 levels compared to secondary RPF. The IgG4-RPF patients were likely to have higher serum IgG4 levels and lower serum C-reactive protein, ferritin, and C3 levels compared to the idiopathic RPF patients without IgG4-RD. These findings might reflect underlying systemic inflammatory responses. Comprehensive laboratory testing, including serum inflammatory markers and immunological panels, is recommended for radiologically diagnosed RPF patients.
Keywords retroperitoneal fibrosis IgG4-related disease malignancy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 527
End Page 536
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899264
Web of Science KeyUT 001108661600010
JaLCDOI 10.18926/AMO/65973
FullText URL 77_5_511.pdf
Author Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi|
Abstract Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required.
Keywords sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 511
End Page 516
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899262
Web of Science KeyUT 001108661600008
JaLCDOI 10.18926/AMO/65972
FullText URL 77_5_499.pdf
Author Hatakeyama, Yuji| Hongo, Michio| Kido, Tadato| Urayama, Masakazu| Kasukawa, Yuji| Sasaki, Hiroshi| Aizawa, Toshiaki| Kudo, Daisuke| Kimura, Ryota| Ono, Yuichi| Kasama, Fumihito| Miyakoshi, Naohisa|
Abstract This study aimed to clarify neurological differences among the epiconus, conus medullaris, and cauda equina syndromes. Eighty-seven patients who underwent surgery for acute thoracolumbar spinal injuries were assessed. We defined the epiconus as the region from the terminal end of the spinal cord to the proximal 1.0 to 2.25 vertebral bodies, the conus medullaris as the region proximal to < 1.0 vertebral bodies, and the cauda equina as the distal part of the nerve roots originating from the spinal cord. On the basis of the distance from the terminal end of the spinal cord to the narrowest level of the spinal canal, the narrowest levels were ordered as follows: the epiconus followed by the conus medullaris and cauda equina. The narrowest levels were the epiconus in 22 patients, conus medullaris in 37 patients, and cauda equina in 25 patients. On admission, significantly more patients had a narrowed epiconus of Frankel grades A-C than a narrowed cauda equina. At the final follow-up, there were no significant differences in neurological recovery among those with epiconus, conus medullaris, or cauda equina syndrome. Anatomically classifying the narrowest lesion is useful for clarifying the differences and similarities among these three syndromes.
Keywords thoracolumbar spinal injury terminal end of spinal cord conus medullaris epiconus syndrome cauda equina syndrome
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 499
End Page 509
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899261
Web of Science KeyUT 001108661600007
JaLCDOI 10.18926/AMO/65971
FullText URL 77_5_491.pdf
Author Habu, Hiroshi| Takao, Soshi| Miyaji, Chikara| Matsumoto, Naomi| Aoo, Ken| Nishita, Yosuke| Tsuri, Masao| Yorifuji, Takashi|
Abstract Arts festivals have become increasingly popular in various parts of Japan in recent years. The purpose of this study was to investigate the relationships between arts festival activities participation at the Setouchi Triennale and the health of residents in the town of Naoshima. This was a cross-sectional study. Questionnaires were distributed to all residents of Naoshima who were 20 years old or older (n=2,588). We analyzed responses from 708 people. The associations between arts festival activities participation and health (measured by self-rated health) were analyzed using logistic regression analysis as the primary outcome. Kessler’s psychological distress scale scores were also analyzed in the same manner as the primary outcome. The participating group had an adjusted odds ratio of 1.86 (95% confidence interval: 1.03-3.33) for higher self-rated health compared with those who did not participate. Kessler’s psychological distress scale results showed that the participating group had an adjusted odds ratio of 3.23 (95% confidence interval: 1.19-8.81) for lower psychological distress compared with those who did not participate. In conclusion, arts festival activities participation was associated with higher self-rated health and lower psychological distress. However, caution must be taken in regard to generalizability and causality when interpreting these results.
Keywords art arts in public health arts festival self-rated health Setouchi Triennale
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 491
End Page 497
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899260
Web of Science KeyUT 001108661600006
JaLCDOI 10.18926/AMO/65967
FullText URL 77_5_451.pdf
Author Okita, Atsushi| Tsukuda, Kazunori| Ino, Hideo| Mitsui, Ema| Ikeya, Nanami| Yamamoto, Sumiharu| Yokoyama, Nobuji| Bulin, Aubra|
Abstract Using a Collaborative Action Research model, our research team established a one-month clinical resident training program for first- and second-year clinical residents. We created and implemented an assessment rubric to assess the residents’ progress toward independent practice in surgery, and thereby, to evaluate the program itself. The program included training in three areas: basic techniques and procedures in the operating room, surgical ward management, and academic activities. The rubric measured the residents’ performance according to three achievement levels: Level 1 (demonstration), Level 2 (active help) and Level 3 (passive help). The program and rubric implementation began in June 2019 and continued until March 2020, when the program outcomes and shortcomings were analyzed. Among nineteen clinical residents, a total of nine clinical residents participated in the study. Most participants reached achievement Level 3 for their performance of basic techniques in the operating room. Finally, we discussed ideas for improvement and drafted plans for an improved rubric to complete the action research cycle. Our research team found the rubric to be a useful tool in evaluating the status of the new clinical resident training program.
Keywords resident program rubric assessment general surgery action research
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 451
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899256
Web of Science KeyUT 001108661600002
FullText URL fulltext.pdf
Author Umemori, Koki| Ono, Kisho| Kanemoto, Hideka| Obata, Kyoichi| Kawai, Hotaka| Nakamura, Tomoya| Nakano, Keisuke| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords Pleomorphic adenoma (PA) upper lip lower lip minor salivary gland tumor case series
Published Date 2022-10-27
Publication Title Gland Surgery
Volume volume11
Issue issue10
Publisher AME Publishing Company
Start Page 1730
End Page 1740
ISSN 2227-684X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Gland Surgery.
File Version publisher
PubMed ID 36353586
DOI 10.21037/gs-22-308
Web of Science KeyUT 000860255900001
Related Url isVersionOf https://doi.org/10.21037/gs-22-308
FullText URL fulltext20230923-01.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro|
Keywords myxoma orbital CD34 ethmoid sinus literature review
Published Date 2023-09-22
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume11
Publisher SAGE Publications
Start Page 1
End Page 6
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 American Federation for Medical Research
File Version publisher
PubMed ID 37737575
DOI 10.1177/23247096231201013
Web of Science KeyUT 001070220300001
Related Url isVersionOf https://doi.org/10.1177/23247096231201013
JaLCDOI 10.18926/AMO/65755
FullText URL 77_4_429.pdf
Author Sasanami, Misa| Iida, Atsuyoshi| Iwamuro, Masaya| Hirai, Ryousuke| Obara, Takashi| Tsukahara, Kohei| Yumoto, Tetsuya| Naito, Hiromichi| Nakao, Atsunori|
Abstract Intramural esophageal dissection (IED), characterized by bleeding into the submucosal space, leads to mucosal separation and dissection. The most prevalent symptoms are sudden chest or retrosternal pain, hematemesis, and dysphagia. Therefore, acute coronary syndrome and aortic dissection are among its most notable differential diagnoses. A 31-year-old pregnant woman presented with acute chest pain, laryngeal discomfort, and hematemesis. Emergency esophagogastroscopy revealed longitudinal mucosal dissection (upper esophagus to esophagogastric junction). The patient was successfully treated by avoiding the ingestion of solid foods. Clinicians should consider a diagnosis of IED for pregnant patients with acute chest pain, especially if hematemesis is present.
Keywords chest pain dysphagia esophageal dissection hematemesis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 429
End Page 431
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635144
Web of Science KeyUT 001163659800012
JaLCDOI 10.18926/AMO/65751
FullText URL 77_4_407.pdf
Author Hotta, Kensuke| Kobayashi, Takaomi|
Abstract This study aimed to investigate the usefulness of force-controlled pelvic stress radiographs in the evaluation and treatment of fragility fractures of the pelvis (FFP) using a functional treatment strategy. We conducted a retrospective study of 55 geriatric patients with FFP who underwent pelvic stress radiographs on admission. The differences in the sacral width, pelvic ring width, and medial femoral head width between the radiographs with and without the Sam Sling II M size were defined as Δ sacral width, Δ pelvic ring width, and Δ medial femoral head width, respectively. We used Pearson’s correlation test to assess the relationship between the degree of radiographic instability and the Johns Hopkins highest level of mobility scale (JH-HLM) at 10-days postadmission. Conventional receiver-operating-characteristic curve analysis was used to identify cases requiring surgery using the best cutoff value for radiographic instability. The JH-HLM was significantly correlated with Δ sacral width (r=−0.401, p=0.017), but not with Δ pelvic ring width (r=−0.298, p=0.080) nor with Δ medial femoral head width (r= −0.261, p=0.128). The best cutoff value of Δ sacral width in identifying surgical cases was 10.7 mm (sensitivity 75.0%, specificity 98.0%). Force-controlled pelvic stress radiographs could be helpful in assessing the need for surgery on admission.
Keywords fragility fracture of the pelvis functional treatment strategy Sam Sling stress radiograph Johns Hopkins highest level of mobility scale
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 407
End Page 414
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635141
Web of Science KeyUT 001163659800001
FullText URL fulltext.pdf
Author Umakoshi, Noriyuki| Matsui, Yusuke| Tomita, Koji| Uka, Mayu| Kawabata, Takahiro| Iguchi, Toshihiro| Hiraki, Takao|
Keywords hepatocellular carcinoma extrahepatic metastases ablation therapy radiofrequency ablation microwave ablation cryoablation percutaneous ethanol injection
Published Date 2023-07-18
Publication Title Cancers
Volume volume15
Issue issue14
Publisher MDPI
Start Page 3665
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37509326
DOI 10.3390/cancers15143665
Web of Science KeyUT 001035192500001
Related Url isVersionOf https://doi.org/10.3390/cancers15143665
FullText URL fulltext20230712-01.pdf
Author Matsuo, Toshihiko| Okubo, Kohei| Mifune, Hirofumi| Imao, Takeshi|
Keywords COVID-19 mRNA vaccine lymphocytic hypophysitis diabetes insipidus optic neuritis multiple sclerosis
Published Date 2023-07-11
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume11
Publisher SAGE Publications
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 American Federation for Medical Research
File Version publisher
PubMed ID 37431875
DOI 10.1177/23247096231186046
Related Url isVersionOf https://doi.org/10.1177/23247096231186046
FullText URL fulltext20230708-01.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Okada, Kazuya| Notohara, Kenji| Fujii, Keiko| Fujii, Nobuharu|
Keywords mantle cell lymphoma lacrimal gland autologous peripheral blood stem cell transplantation breast cancer tracheal and bronchial infiltration
Published Date 2023-07-05
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume11
Publisher SAGE Publications
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 American Federation for Medical Research
File Version publisher
PubMed ID 37403948
DOI 10.1177/23247096231185483
Related Url isVersionOf https://doi.org/10.1177/23247096231185483
FullText URL fulltext20230911-02.pdf
Author Ninomiya, Kiichiro| Inoue, Daisuke| Sugimoto, Ken| Tanaka, Chie| Murofushi, Keiko| Okuyama, Toru| Watanuki, Shigeaki| Imamura, Chiyo K.| Sakai, Daisuke| Sakurai, Naomi| Watanabe, Kiyotaka| Tamura, Kazuo| Saeki, Toshiaki| Ishiguro, Hiroshi|
Keywords Comprehensive geriatric assessment Guideline Systematic review
Published Date 2023-06-11
Publication Title Journal of Geriatric Oncology
Volume volume14
Issue issue5
Publisher Elsevier
Start Page 101485
ISSN 18794068
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37062639
DOI 10.1016/j.jgo.2023.101485
Web of Science KeyUT 001049053400001
Related Url isVersionOf https://doi.org/10.1016/j.jgo.2023.101485
FullText URL fulltext.pdf
Author Kawada, Tatsushi| Laukhtina, Ekaterina| Quhal, Fahad| Yanagisawa, Takafumi| Rajwa, Pawel| Pallauf, Maximilian| von Deimling, Markus| Bianchi, Alberto| Pradere, Benjamin| Fajkovic, Harun| Enikeev, Dmitry| Gontero, Paolo| Rouprêt, Morgan| Seisen, Thomas| Araki, Motoo| Shariat, Shahrokh F.|
Keywords Upper tract urothelial carcinoma Endoscopic surgery
Published Date 2023-03
Publication Title European Urology Focus
Volume volume9
Issue issue2
Publisher Elsevier
Start Page 236
End Page 240
ISSN 2405-4569
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 36463089
DOI 10.1016/j.euf.2022.11.016
Web of Science KeyUT 000995299200001
Related Url isVersionOf https://doi.org/10.1016/j.euf.2022.11.016
FullText URL fulltext20230625-01.pdf
Author Matsuo, Toshihiko| Hiramatsu‐Asano, Sumie| Sawachika, Hiroshi| Nishimura, Hirotake|
Keywords ANCA-associated vasculitis corneal melt and perforation rituximab scleritis temporal artery biopsy
Published Date 2023-06-20
Publication Title Clinical Case Reports
Volume volume11
Issue issue6
Publisher Wiley
Start Page e7595
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37351359
DOI 10.1002/ccr3.7595
Related Url isVersionOf https://doi.org/10.1002/ccr3.7595
JaLCDOI 10.18926/AMO/65502
FullText URL 77_3_323.pdf
Author Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao|
Abstract In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.
Keywords comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 323
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357634
Web of Science KeyUT 001025850000001
JaLCDOI 10.18926/AMO/65492
FullText URL 77_3_273.pdf
Author Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi|
Abstract Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
Keywords simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357628
Web of Science KeyUT 001026279600005